WO2006008294A3 - Diagnostic and therapeutic use of slim3 for neurodegenerative diseases - Google Patents

Diagnostic and therapeutic use of slim3 for neurodegenerative diseases Download PDF

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Publication number
WO2006008294A3
WO2006008294A3 PCT/EP2005/053468 EP2005053468W WO2006008294A3 WO 2006008294 A3 WO2006008294 A3 WO 2006008294A3 EP 2005053468 W EP2005053468 W EP 2005053468W WO 2006008294 A3 WO2006008294 A3 WO 2006008294A3
Authority
WO
WIPO (PCT)
Prior art keywords
slim3
disease
alzheimer
provides
neurodegenerative diseases
Prior art date
Application number
PCT/EP2005/053468
Other languages
French (fr)
Other versions
WO2006008294A2 (en
Inventor
Der Kammer Heinz Von
Johannes Pohlner
Original Assignee
Evotec Neurosciences Gmbh
Der Kammer Heinz Von
Johannes Pohlner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Neurosciences Gmbh, Der Kammer Heinz Von, Johannes Pohlner filed Critical Evotec Neurosciences Gmbh
Priority to EP05777722A priority Critical patent/EP1771578A2/en
Publication of WO2006008294A2 publication Critical patent/WO2006008294A2/en
Publication of WO2006008294A3 publication Critical patent/WO2006008294A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides a protein encoded by the SLIM3 gene and discloses the differential expression of the g e n e SLIM3 coding for SLIM3 proteins in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the SLIM3 gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
PCT/EP2005/053468 2004-07-23 2005-07-19 Diagnostic and therapeutic use of slim3 for neurodegenerative diseases WO2006008294A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05777722A EP1771578A2 (en) 2004-07-23 2005-07-19 Diagnostic and therapeutic use of slim3 for neurodegenerative diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59037204P 2004-07-23 2004-07-23
US60/590,372 2004-07-23

Publications (2)

Publication Number Publication Date
WO2006008294A2 WO2006008294A2 (en) 2006-01-26
WO2006008294A3 true WO2006008294A3 (en) 2006-10-19

Family

ID=35785591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/053468 WO2006008294A2 (en) 2004-07-23 2005-07-19 Diagnostic and therapeutic use of slim3 for neurodegenerative diseases

Country Status (2)

Country Link
EP (1) EP1771578A2 (en)
WO (1) WO2006008294A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016636A2 (en) * 2000-08-24 2002-02-28 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
WO2003054152A2 (en) * 2001-12-10 2003-07-03 Nuvelo, Inc. Novel nucleic acids and polypeptides
WO2003087768A2 (en) * 2002-04-12 2003-10-23 Mitokor Targets for therapeutic intervention identified in the mitochondrial proteome
WO2003100092A2 (en) * 2002-05-28 2003-12-04 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of cyp11a1 for neurodegenerative diseases
EP1491895A1 (en) * 2003-06-24 2004-12-29 Universitätsklinikum Freiburg Modulation of osteoblast activity by Fhl2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016636A2 (en) * 2000-08-24 2002-02-28 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
WO2003054152A2 (en) * 2001-12-10 2003-07-03 Nuvelo, Inc. Novel nucleic acids and polypeptides
WO2003087768A2 (en) * 2002-04-12 2003-10-23 Mitokor Targets for therapeutic intervention identified in the mitochondrial proteome
WO2003100092A2 (en) * 2002-05-28 2003-12-04 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of cyp11a1 for neurodegenerative diseases
EP1491895A1 (en) * 2003-06-24 2004-12-29 Universitätsklinikum Freiburg Modulation of osteoblast activity by Fhl2

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group.", NEUROBIOLOGY OF AGING. UNITED STATES 1998 MAR-APR, vol. 19, no. 2, March 1998 (1998-03-01), pages 109 - 116, XP002233088, ISSN: 0197-4580 *
ALBRECHT C ET AL: "Spatio - temporal gene expression profiling in Alzheimer's disease.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, & 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 202.18 URL - http://sf, XP008062372 *
CHAN K K ET AL: "Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER, AMSTERDAM, NL, vol. 210, no. 2, 14 April 1998 (1998-04-14), pages 345 - 350, XP004118187, ISSN: 0378-1119 *
DATABASE UniProt [online] 1 November 1997 (1997-11-01), "Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3) (LIM-domain protein DRAL).", XP002377336, retrieved from EBI accession no. UNIPROT:FHL2_HUMAN Database accession no. FHL2_HUMAN *
LORING J F ET AL: "A gene expression profile of Alzheimer's disease.", DNA AND CELL BIOLOGY. UNITED STATES NOV 2001, vol. 20, no. 11, November 2001 (2001-11-01), pages 683 - 695, XP002233087, ISSN: 1044-5498 *
TANAHASHI H ET AL: "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.", HUMAN MOLECULAR GENETICS. 22 SEP 2000, vol. 9, no. 15, 22 September 2000 (2000-09-22), pages 2281 - 2289, XP002374761, ISSN: 0964-6906 *

Also Published As

Publication number Publication date
WO2006008294A2 (en) 2006-01-26
EP1771578A2 (en) 2007-04-11

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