WO2006001954A3 - Methods for promoting the formation of platelets and for treating blood and bone marrow disorders - Google Patents

Methods for promoting the formation of platelets and for treating blood and bone marrow disorders Download PDF

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Publication number
WO2006001954A3
WO2006001954A3 PCT/US2005/017735 US2005017735W WO2006001954A3 WO 2006001954 A3 WO2006001954 A3 WO 2006001954A3 US 2005017735 W US2005017735 W US 2005017735W WO 2006001954 A3 WO2006001954 A3 WO 2006001954A3
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WO
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Patent type
Prior art keywords
methods
bone marrow
promoting
platelets
treating blood
Prior art date
Application number
PCT/US2005/017735
Other languages
French (fr)
Other versions
WO2006001954A2 (en )
Inventor
Jonathan G Drachman
Brian J Lannutti
Manish Gandhi
Original Assignee
Puget Sound Blood Ct And Progr
Jonathan G Drachman
Brian J Lannutti
Manish Gandhi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol

Abstract

The invention provides methods for promoting the differentiation of megakaryocytes, methods for forming platelets, and methods for reducing the number of abnormal or malignant cells in bone marrow. In some embodiments, the methods comprise the step of contacting megakaryocyte progenitors with an amount of a 3-(cyclohexanoheteroarylidenyl)-2-indolinone compound effective to promote their differentiation. In some embodiments, the 3-(cyclohexanoheteroarylidenyl)-2-indolinone compound is 2-oxo-3-(4, 5, 6, 7-tetrahydro-lH-indol-2-ylmethylene)-2,3-dihydro-lH-indole-5-sulfonic acid dimethylamide (SU6656). The invention also provides methods for treating blood and bone marrow disorders.
PCT/US2005/017735 2004-05-20 2005-05-20 Methods for promoting the formation of platelets and for treating blood and bone marrow disorders WO2006001954A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US57344704 true 2004-05-20 2004-05-20
US60/573,447 2004-05-20
US62040204 true 2004-10-19 2004-10-19
US60/620,402 2004-10-19

Publications (2)

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WO2006001954A2 true WO2006001954A2 (en) 2006-01-05
WO2006001954A3 true true WO2006001954A3 (en) 2006-03-23

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PCT/US2005/017735 WO2006001954A3 (en) 2004-05-20 2005-05-20 Methods for promoting the formation of platelets and for treating blood and bone marrow disorders

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WO (1) WO2006001954A3 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008033030A1 (en) 2007-08-20 2009-02-26 Luk Lamellen Und Kupplungsbau Beteiligungs Kg A clutch unit
US8933071B2 (en) 2008-11-07 2015-01-13 Northwestern University Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders
US7897602B2 (en) 2009-01-12 2011-03-01 Development Center For Biotechnology Indolinone compounds as kinase inhibitors
WO2014100636A3 (en) 2012-12-20 2014-08-14 The Trustees Of Columbia University In The City Of New York Methods of treating atherosclerosis or myeloproliferative neoplasms by administering a lyn kinase activator
WO2014100779A8 (en) 2012-12-21 2014-08-14 Advanced Cell Technology, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
CN105308452B (en) 2013-01-03 2018-02-06 布里格姆女子医院有限公司 Fluid handling system and method of the biomimetic
US20160067301A1 (en) * 2013-04-12 2016-03-10 The Trustees Of Columbia University In The City Of New York Antagonism of abcg4, lyn kinase, and c-cbl e3 ligase to increase platelet count as therapy for thrombocytopenia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045689A2 (en) * 1999-12-22 2001-06-28 Sugen, Inc. Indolinone derivatives for modulation of c-kit tyrosine protein kinase
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045689A2 (en) * 1999-12-22 2001-06-28 Sugen, Inc. Indolinone derivatives for modulation of c-kit tyrosine protein kinase
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BLAKE R A ET AL: "SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 20, no. 23, December 2000 (2000-12-01), pages 9018 - 9027, XP002989060, ISSN: 0270-7306 *
BROOME MARTIN A ET AL: "Selective Src family kinase inhibitors as potential therapeutic agents for cancer", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 836, XP008059117, ISSN: 0197-016X *
DUEHRSEN U ET AL: "EFFECTS OF VASCULAR ENDOTHELIAL AND PLATELET-DERIVED GROWTH FACTOR RECEPTOR INHIIBITORS ON LONG-TERM CULTURES FROM NORMAL HUMAN BONE MARROW", GROWTH FACTORS, HARWOOD ACADEMIC PUBLISHERS GMBH, vol. 19, no. 1, 2001, pages 1 - 17, XP009020567, ISSN: 0897-7194 *
LANNUTTI BRIAN J ET AL: "Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.", BLOOD, vol. 104, no. 11, Part 1, November 2004 (2004-11-01), & 46TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 04 -07, 2004, pages 797A - 798A, XP008059064, ISSN: 0006-4971 *
LANNUTTI BRIAN J ET AL: "Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.", BLOOD. 15 MAY 2005, vol. 105, no. 10, 15 May 2005 (2005-05-15), pages 3875 - 3878, XP008059078, ISSN: 0006-4971 *
LANNUTTI BRIAN J ET AL: "Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors", BLOOD, vol. 103, no. 10, 15 May 2004 (2004-05-15), pages 3736 - 3743, XP008059096, ISSN: 0006-4971 *

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WO2006001954A2 (en) 2006-01-05 application

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