WO2005121357A3 - Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid - Google Patents

Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid Download PDF

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Publication number
WO2005121357A3
WO2005121357A3 PCT/GB2005/002262 GB2005002262W WO2005121357A3 WO 2005121357 A3 WO2005121357 A3 WO 2005121357A3 GB 2005002262 W GB2005002262 W GB 2005002262W WO 2005121357 A3 WO2005121357 A3 WO 2005121357A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound
prognosis
diagnosis
phospholipase
measurement
Prior art date
Application number
PCT/GB2005/002262
Other languages
French (fr)
Other versions
WO2005121357A2 (en
Inventor
Faraia Shah
Rachael Clark
Patrick John Trotter
Paul William Watt
Breda Mary Cullen
Original Assignee
Ethicon Inc
Faraia Shah
Rachael Clark
Patrick John Trotter
Paul William Watt
Breda Mary Cullen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0413078A external-priority patent/GB2415039B/en
Application filed by Ethicon Inc, Faraia Shah, Rachael Clark, Patrick John Trotter, Paul William Watt, Breda Mary Cullen filed Critical Ethicon Inc
Priority to CA002569959A priority Critical patent/CA2569959A1/en
Priority to EP05748372A priority patent/EP1756298B1/en
Priority to US11/608,940 priority patent/US8685639B2/en
Priority to DE602005021782T priority patent/DE602005021782D1/en
Publication of WO2005121357A2 publication Critical patent/WO2005121357A2/en
Publication of WO2005121357A3 publication Critical patent/WO2005121357A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to the diagnosis, prognosis and/or treatment of wound infection by testing wound fluid for the presence of a marker which is present in an amount which is indicative of infection. The marker may be high molecular weight phospholipase A2 (cPLA2) or a marker which is correlated with cPLA2.
PCT/GB2005/002262 2004-06-11 2005-06-09 Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid WO2005121357A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002569959A CA2569959A1 (en) 2004-06-11 2005-06-09 Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid
EP05748372A EP1756298B1 (en) 2004-06-11 2005-06-09 Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid
US11/608,940 US8685639B2 (en) 2004-06-11 2005-06-09 Diagnosis and prognosis of wound infection by measurement of a phospholipase A2 in wound fluid
DE602005021782T DE602005021782D1 (en) 2004-06-11 2005-06-09 WOUND INFECTION DIAGNOSIS AND PROGNOSIS BY MEASURING A PHOSPHOLIPASE A2 IN WATER LIQUID

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0413078.7 2004-06-11
GB0413078A GB2415039B (en) 2004-06-11 2004-06-11 Diagnosis and prognosis
US62583004P 2004-11-08 2004-11-08
US60/625,830 2004-11-08

Publications (2)

Publication Number Publication Date
WO2005121357A2 WO2005121357A2 (en) 2005-12-22
WO2005121357A3 true WO2005121357A3 (en) 2006-06-01

Family

ID=34981549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/002262 WO2005121357A2 (en) 2004-06-11 2005-06-09 Diagnosis and prognosis of wound infection by measurement of a phospholipase a2 in wound fluid

Country Status (5)

Country Link
EP (1) EP1756298B1 (en)
CA (1) CA2569959A1 (en)
DE (1) DE602005021782D1 (en)
ES (1) ES2344210T3 (en)
WO (1) WO2005121357A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0806186D0 (en) * 2008-04-04 2008-05-14 Axis Shield Diagnostics Ltd Method
WO2017182765A1 (en) * 2016-04-18 2017-10-26 Swansea University Method of detecting bacterial infection in a biological sample
KR102696154B1 (en) * 2017-11-08 2024-08-19 묄른뤼케 헬스 케어 에이비 A novel biosensor and associated wound dressing system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005479A1 (en) * 1993-08-17 1995-02-23 The Regents Of The University Of California Assay and substrate for arachidonoyl-specific phospholipase a¿2?
WO2000054052A2 (en) * 1999-03-09 2000-09-14 Laxdale Limited Diagnostic test
WO2003040406A2 (en) * 2001-11-05 2003-05-15 Johnson & Johnson Medical Limited Diagnosis of clinical infection of a wound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005479A1 (en) * 1993-08-17 1995-02-23 The Regents Of The University Of California Assay and substrate for arachidonoyl-specific phospholipase a¿2?
WO2000054052A2 (en) * 1999-03-09 2000-09-14 Laxdale Limited Diagnostic test
WO2003040406A2 (en) * 2001-11-05 2003-05-15 Johnson & Johnson Medical Limited Diagnosis of clinical infection of a wound

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAMOOD ABDUL N ET AL: "Production of extracellular virulence factors for Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections", JOURNAL OF SURGICAL RESEARCH, vol. 61, no. 2, 1996, pages 425 - 432, XP002349625, ISSN: 0022-4804 *

Also Published As

Publication number Publication date
WO2005121357A2 (en) 2005-12-22
EP1756298A2 (en) 2007-02-28
CA2569959A1 (en) 2005-12-22
EP1756298B1 (en) 2010-06-09
DE602005021782D1 (en) 2010-07-22
ES2344210T3 (en) 2010-08-20

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