WO2005121062A3 - Process for the preparation of pravastatin - Google Patents

Process for the preparation of pravastatin Download PDF

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Publication number
WO2005121062A3
WO2005121062A3 PCT/IB2005/051884 IB2005051884W WO2005121062A3 WO 2005121062 A3 WO2005121062 A3 WO 2005121062A3 IB 2005051884 W IB2005051884 W IB 2005051884W WO 2005121062 A3 WO2005121062 A3 WO 2005121062A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pravastatin
relates
pure pravastatin
compositions
Prior art date
Application number
PCT/IB2005/051884
Other languages
French (fr)
Other versions
WO2005121062A2 (en
Inventor
Parveen Kumar
Srinivasan Raman
Ashoke Mitra
Original Assignee
Ranbaxy Lab Ltd
Parveen Kumar
Srinivasan Raman
Ashoke Mitra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Parveen Kumar, Srinivasan Raman, Ashoke Mitra filed Critical Ranbaxy Lab Ltd
Publication of WO2005121062A2 publication Critical patent/WO2005121062A2/en
Publication of WO2005121062A3 publication Critical patent/WO2005121062A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

The invention relates to a process for the preparation of pure pravastatin or a salt thereof using an adsorption chromatography technique. The invention also relates to pharmaceutical compositions that include the pure pravastatin and to use of the compositions for treating hypercholesterolemia.
PCT/IB2005/051884 2004-06-09 2005-06-08 Process for the preparation of pravastatin WO2005121062A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1086DE2004 2004-06-09
IN1086/DEL/2004 2004-06-09

Publications (2)

Publication Number Publication Date
WO2005121062A2 WO2005121062A2 (en) 2005-12-22
WO2005121062A3 true WO2005121062A3 (en) 2006-03-09

Family

ID=34970302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/051884 WO2005121062A2 (en) 2004-06-09 2005-06-08 Process for the preparation of pravastatin

Country Status (1)

Country Link
WO (1) WO2005121062A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104045557B (en) * 2014-06-25 2015-10-21 上海华震科技有限公司 A kind of high purity Pravastatin sodium purifying process

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0605230A1 (en) * 1992-12-28 1994-07-06 Sankyo Company Limited Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses
US20020081675A1 (en) * 1999-02-03 2002-06-27 Antonia Jekkel Microbial process for preparing pravastatin
KR20020071637A (en) * 2001-03-07 2002-09-13 코바이오텍 (주) A purification method of pravastatin using methanol
WO2003042373A1 (en) * 2001-09-29 2003-05-22 Kobiotech Co.Ltd. Process for preparing pravastatin sodium
US20040138294A1 (en) * 1998-09-18 2004-07-15 Rok Grahek Process for obtaining HMG-CoA reductase inhibitors of high purity
WO2005051372A2 (en) * 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0605230A1 (en) * 1992-12-28 1994-07-06 Sankyo Company Limited Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses
US20040138294A1 (en) * 1998-09-18 2004-07-15 Rok Grahek Process for obtaining HMG-CoA reductase inhibitors of high purity
US20020081675A1 (en) * 1999-02-03 2002-06-27 Antonia Jekkel Microbial process for preparing pravastatin
KR20020071637A (en) * 2001-03-07 2002-09-13 코바이오텍 (주) A purification method of pravastatin using methanol
WO2003042373A1 (en) * 2001-09-29 2003-05-22 Kobiotech Co.Ltd. Process for preparing pravastatin sodium
WO2005051372A2 (en) * 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200314, Derwent World Patents Index; Class B05, AN 2003-145597, XP002345893 *

Also Published As

Publication number Publication date
WO2005121062A2 (en) 2005-12-22

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