WO2005120621A1

WO2005120621A1 - Intravascular indwelling catheter

Info

Publication number: WO2005120621A1
Application number: PCT/JP2005/010747
Authority: WO
Inventors: Hiroshi Shibahara; Osamu Isogai; Hiroyuki Kojima; Norio Koike
Original assignee: Unitika Ltd.
Priority date: 2004-06-10
Filing date: 2005-06-07
Publication date: 2005-12-22
Also published as: JP4819327B2; JP2005348947A

Abstract

An intravascular indwelling catheter, wherein an outer catheter (1) and inner catheters (21, 22) detachably fitted to the outer catheter (1) in the lumen of the outer catheter (1). The inner catheters are formed of two or more single layer lumen catheters (21, 22) or one or more multi-layer lumen catheters.

Description

Technical Field of Intravascular Catheter

The present invention relates to an intravascular indwelling catheter. More specifically, various medical treatments such as blood purification, infusion and administration of drug solution, blood collection, measurement of pulse pressure and blood flow, electrophysiological examination or temporary and short-term extracorporeal cardiac pacing, etc. The present invention relates to an intravascular indwelling catheter used for diagnosis and treatment. book

Background art

Conventionally, central venous indwelling catheters have been used for patients who need to administer infusions and drug solutions (see Non-Patent Document 1). In addition, blood purification is necessary for diseases such as renal failure, diabetes, drug poisoning, systemic inflammatory response syndrome (SIRS), acute respiratory distress syndrome (ARDS), multiple organ failure (M0F), hepatitis, and knee inflammation For patients with the above-mentioned, a blood access force table that uses a catheter placed in a blood vessel to remove blood is used (see Non-Patent Document 2). In addition, for patients who need to measure central venous pressure and blood flow, a pulse pressure measurement catheter that is placed in the blood vessel and measures venous pressure, and a thermodie that measures blood flow such as cardiac output Reuse catheters are used (see Non-Patent Document 3). There are also short-term pacing catheters used as short-term extracorporeal electrodes for cardiac pacemakers.

The above-mentioned catheters usually have a structure in which the lumen of one catheter is divided into a single layer or multiple layers according to the purpose. It has a structure in which electrical signals flow as sensors for measuring blood flow.

FIGS. 5A and 5B show a blood access catheter used in hemodialysis and the like as a related technique of the present invention, wherein a coaxial catheter in which a detachable inner catheter is inserted into a lumen of an outer catheter. To Disclose. In this catheter, blood is removed using an outer catheter, and blood is sent using an inner catheter, and an obturator (internal plug) is inserted when not in use. (See Non-Patent Document 4).

[Non-patent document 1] Edited by the Japan Society for Parenteral and Enteral Nutrition: Guidelines for Co-medical Intravenous and Enteral Nutrition, 43, Nankodo (2000)

[Non-patent Document 2] Yuhei Hirasawa: Dialysis Therapy Manual (Revised 5th Edition), 170, Japan Medical Center (1999)

[Non-patent document 3] Sanae Tsuruta, Kazuko Harada: Postoperative treatment manual, 66, Shorinsha (1991) [Non-patent document 4] Shigeru Takagata, Ryuji Hongo, Akira Matsuzaki, Ryuzo Kato, Koetsu Kobayashi, Tadashi Harada , Masayoshi Tsuchida: Invention of Double Noremen Type UK Catheter, Journal of the Japan Dialysis Medical Association ⁵ (4), 220 (199 0)

The above-mentioned single-layer catheter with a single-lumen catheter is made for single-use purposes, and the catheter needs to be placed or replaced according to the purpose.As a result, frequent punctures to the patient are indispensable It was. In addition, even when a single catheter having a lumen divided into multiple layers is used for a plurality of purposes, the lumen is blocked by blood or a drug solution, or sticks to a blood vessel wall when blood is sucked from a side hole of the catheter. If a trouble occurs that cannot achieve its purpose, such as the inability to aspirate due to a problem, for example, even if other lumens than the intended lumen can be used, it is necessary to replace the entire indwelling force catheter, This not only puts a great physical and mental burden on both patients, but also causes a great loss in healthcare economy.

Frequent catheter replacement due to such troubles increases the risk of infection due to the invasion of pathogens and the possibility of blockage of blood vessels themselves, systemic inflammatory reaction symptoms, acute respiratory distress syndrome, multiple organs This was a particularly serious problem for patients at high risk of infection due to reduced immune function such as insufficiency and leukemia, elderly people with fragile blood vessels, undeveloped infants and children with narrow blood vessels.

In addition, as with the above-mentioned catheter, even if the inner catheter becomes unusable due to occlusion, replacement is possible, but the outer catheter becomes occluded or has poor blood removal. Is It was necessary to remove the catheter itself, that is, to replace the entire catheter. Disclosure of the invention

In one or more embodiments of the present invention, the indwelling catheter is

An outer catheter; and an inner catheter which is inserted through the lumen of the outer catheter and is detachably fitted to the outer catheter. The inner catheter comprises two or more single-lumen catheters or one or more multi-lumen catheters. Further, in one or more embodiments of the present invention, two or more single-layer lumen catheters or multiple-layer lumen catheters constituting the inner catheter are separately detachable.

In one or more embodiments of the present invention, the catheter for indwelling in a blood vessel may be provided with a therapeutic or diagnostic sensor through a lumen of an inner catheter, and may also have a therapeutic or diagnostic sensor function. It is a catheter for indwelling in a blood vessel. Further, in one or more embodiments of the present invention, the intravascular indwelling catheter may further include a cardiac pacemaker electrode mounted through a lumen of the inner catheter. It is a utility Tetenore.

In one or more embodiments of the present invention, the intravascular indwelling catheter includes a connector part provided on the outer catheter, a plurality of connection parts provided integrally with the connector and provided on an upper part of the connector part, A screw provided at each connection portion; and an ack ring provided at each of the inner catheters and fastened with the screw.

In one or more embodiments of the present invention, the intravascular indwelling catheter includes a connector part provided on the outer catheter, an attachment screwed to the connector part, and a plurality of parts integrally provided with the attachment. And a connection part. Each of the inner catheters is connected to the outer catheter via a connection. In one or more embodiments of the present invention, an intravascular indwelling catheter includes: a connector part provided on an outer catheter; and a Y tube part provided on an inner catheter and screwed to the connector part. .

In one or more embodiments of the present invention, the intravascular indwelling catheter includes an attachment for connecting the outer catheter and the inner catheter. The attachment has a screw structure whose length can be adjusted.

In one or more embodiments of the present invention, an intravascular indwelling catheter includes an bellows-type attachment that connects an outer catheter and an inner catheter and has an adjustable length.

In one or more embodiments of the present invention, the indwelling catheter is

A plurality of detachable attachments for connecting the outer catheter and the inner catheter. By changing the number of detachable attachments, the length of the entire attachment is adjusted.

Other features and advantages are apparent from the description of the examples and the appended claims. According to one or more embodiments of the present invention, one inner catheter indwelled in a blood vessel can be selectively mounted with an inner catheter having a shape and a number suitable for various purposes, and can be occluded. When troubles such as occur, a new inner catheter can be easily replaced, and when unnecessary, an obturator (inner plug) can be inserted to seal the entire lumen. In addition, a device having a means for removing or collecting a thrombus formed on the outer periphery or the lumen of the catheter during placement can be introduced, so that the catheter can be placed for a long time.

In addition, regular replacement of the inner catheter can be easily performed to prevent infection. The outer catheter provided with a cuff can be in close contact with the subcutaneous tissue. Brief Description of Drawings FIG. 1A is a schematic diagram showing an example of connecting an inner catheter composed of two single-layer lumen catheters to an arter catheter in one or more embodiments of the present invention.

FIG. 1B is a cross-sectional view taken along the line IB-IB of FIG. 1A.

FIG. 2A is a schematic diagram illustrating an example of a cross-sectional view illustrating an inner surface of a connector portion of an outer force tail according to one or more embodiments of the present invention.

FIG. 2B is a sectional view taken along the line ΠB-ΠB in FIG. 1A.

FIG. 3A is a schematic diagram illustrating an example of mounting two inner catheters on an outer force table in one or more embodiments of the present invention.

Fig. 3B is a cross-sectional view of Fig. 3A.

FIG. 4A is a lateral view showing an example of a partial shape of a connector for mounting three inner catheters in an outer catheter according to one or more embodiments of the present invention.

FIG. 4B is a top view showing an example of a partial shape of a connector for mounting three inner catheters in the outer catheter of one or more embodiments of the present invention.

FIG. 5A is a schematic view of the shape of a coaxial blood access catheter according to the related art of the present invention.

Figure 5B is a cross-sectional view of VB -VB in Figure 5A.

FIG. 6A is a cross-sectional view illustrating an example of a partial structure of an adapter of an inner force table according to one or more embodiments of the present invention.

FIG. 6B is a perspective view of a lateral surface showing an example of a partial structure of the adapter of the inner force table according to one or more embodiments of the present invention.

FIG.7A is a schematic diagram showing an example of an attachment fitted to a part of a connector of an outer catheter for mounting two inner force catheters in one or more embodiments of the present invention. FIG. 5 is a view from the side of an attachment for attaching the inner catheter of FIG.

FIG. 7B illustrates two inner contacts in one or more embodiments of the invention. FIG. 4 is a schematic view showing an example of an attachment fitted to a part of a connector of an outer catheter for attaching a catheter, as viewed from above an attachment for attaching two inner catheters.

FIG.8A is a schematic view showing an example of an attachment fitted to a part of a connector of an outer catheter for mounting three inner force catheters according to one or more embodiments of the present invention. FIG. 5 is a view from the side of an attachment for attaching the inner catheter of FIG.

FIG.8B is a schematic view showing an example of an attachment fitted to a part of a connector of an outer catheter for mounting three inner force catheters according to one or more embodiments of the present invention. FIG. 2 is a view from above of an attachment for mounting the inner catheter.

FIG. 9A is a schematic view showing an example of an attachment to be fitted to a part of a connector of an outer catheter for mounting a double-lumen inner catheter in one or more embodiments of the present invention. FIG.

FIG.9B is a schematic diagram showing an example of an attachment fitted to a part of a connector of an outer catheter for mounting a double-lumen inner catheter according to one or more embodiments of the present invention. FIG.

FIG. 1 OA is a schematic diagram showing an example of the structure of a screw-type attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter in one or more embodiments of the present invention. The schematic diagram which shows the whole shape which mounted | wore the outer catheter and the inner force catheter.

FIG. 10B is a schematic view showing an example of the structure of a screw-type attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter according to one or more embodiments of the present invention. Schematic diagram showing the structure of the attachment.

FIG. 11A illustrates a bellows-type device that can finely adjust the length of an inner catheter attached to an outer catheter in one or more embodiments of the present invention. It is the schematic which shows an example of the structure of a tument, The schematic which shows the whole shape which mounted the outer catheter and the inner force catheter.

FIG. 11B is a schematic view showing an example of the structure of a bellows-type attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter in one or more embodiments of the present invention. Schematic diagram showing the structure of the attachment.

FIG.12A is a schematic diagram showing an example of the structure of a combination type attachment that can finely adjust the length of an inner catheter attached to an outer catheter in one or more embodiments of the present invention. FIG. 2 is a schematic diagram showing an overall shape in which an outer catheter and an inner catheter are mounted.

FIG.12B is a schematic view showing an example of the structure of a combination type attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter according to one or more embodiments of the present invention. Schematic diagram showing the structure of the attachment.

FIG. 13A is a schematic diagram showing an example of the structure of a fixed fastening attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter in one or more embodiments of the present invention. FIG. 1 is a schematic view showing the overall shape of an outer catheter and an inner catheter.

FIG.13B is a schematic view showing an example of a structure of a fixed fastening attachment capable of finely adjusting the length of an inner catheter attached to an outer catheter according to one or more embodiments of the present invention. FIG. 2 is a schematic view showing the structure of an attachment.

FIG.13C is a schematic view showing an example of a structure of a fixed fastening attachment that can finely adjust the length of an inner catheter attached to an outer catheter according to one or more embodiments of the present invention. The schematic diagram in which the lock ring 24 of the inner catheter is fitted to the attachment.

FIG. 13D shows a tightening fastener that can fine-tune the length of the inner catheter attached to the outer catheter in one or more embodiments of the present invention. FIG. 3 is a schematic view showing an example of the structure of a fixed attachment, and is a schematic view showing the structure of a lumen of the attachment.

FIG. 14 illustrates an example of an obturator (inner plug) attached to an outer catheter to prevent thrombus formation in a lumen when the inner power tail is not used in one or more embodiments of the present invention. It is a schematic diagram.

FIG. 15 is a schematic diagram illustrating an example of the shape of a device for physically removing a thrombus formed in a lumen of an outer force tail according to one or more embodiments of the present invention.

FIG. 16 is a schematic diagram of a catheter with a cuff attached to an outer catheter for intimate contact with subcutaneous tissue in one or more embodiments of the present invention.

FIG. 17 is a schematic diagram showing an example of an outer catheter in which a side injection portion can be removed and replaced in one or more embodiments of the present invention.

[Explanation of symbols]

1 Outer catheter

2 Vinna Teitenore

3 Obturator (internal stopper)

4 Devices for removing or collecting thrombus

5 Dubno Reno Remen Type Katatenore

6 Attachment

7 skin

8 Subcutaneous tissue

9 blood vessels

1 1 Connector part

1 2 Clamp tube

1 3 Threading section

1 4 Side note

1 5 hub Clamp

Check valve

Screw part

Connection

Shorter inner catheter

Longer inner catheter

Adapter part

Lock ring section

Male luer taper

Female luer taper

Elastic rubber

Tip of inner catheter

Screw shape inside lock ring

Rod-shaped obturator body

Loop wire

Operation unit

Sheath part

Extension

Y tube

Cuff

Screw-type attachment with fine adjustment of length

Bellows attachment with fine adjustment of length

Combination type attachment with fine adjustment of length Tightened fixed attachment with fine adjustment of length Screw structure of attachment body

Elastic bellows type attachment of attachment body Multiple combination type attachment

Slotted screw structure of attachment body 6 5 Lock ring for tightening the inner catheter

6 6 Groove The best mode for carrying out the invention

Hereinafter, one or more embodiments of the present invention will be described in detail.

In one or more embodiments of the present invention, an inner catheter composed of two or more single-layer lumen catheters or one or more multi-layer lumen catheters is removably fitted to the outer catheter.

As the outer catheter used in the present invention or one or more embodiments, what is known as an outer catheter in a conventional coaxial catheter can be similarly used.

In one or more embodiments of the present invention, as a means for detachably fitting the inner catheter and the outer catheter, various methods can be adopted as follows.

a) A method in which a part of the adapter through which a plurality of inner catheters penetrates and is fixed is fitted into a part of the connector of the outer force catheter, and the fitting part is screwed with a mouth ring.

b) A method in which a part of the adapter, through which the inner catheter is penetrated and fixed, is inserted into an integrated connection part formed for each inner catheter in a part of the connector of the outer catheter, and screwed with a lock ring.

c) Method of screwing the connection part in b) to the connector part of the outer catheter via the attachment

d) A method of screwing a rubber attachment having a tapered inner hole into which the Y-tube part of the inner catheter can be inserted into a part of the connector of the outer catheter, and pushing the inner catheter into the inner hole. explain.

Fig. 1A shows the vascular indwelling catheter detachably fitted by the method a) above.

0 1 shows a general view of one tell. FIG. 1A shows a state in which a part of the adapter of the inner catheter is detached from a part of the connector of the outer catheter for convenience of explanation of the fitting method. The inner catheter 2 penetrates and is fixed to the adapter part 23, and the lower part of the adapter part 23 has a male luer taper 25 (see FIGS. 6A and 6B). The inner lumen has a luer taper structure 26 as shown in Fig. 2A so that the connector part 11 of the outer catheter 1 can be fitted and connected to the adapter part 23 to which the inner catheter 2 is fixed. .

A screw portion 19 is formed at the upper connection portion 20 of the connector portion 1 1 of the outer catheter 1, and the adapter ring 23 is attached to and detached from the connector portion 11 by being screwed with the lock ring portion 24. Can be fitted as much as possible.

In a catheter for indwelling a blood vessel, the outer catheter has a side injection portion 14 that can be used as a lumen for blood removal or blood transmission, and a thread hook portion 13 for fixing the catheter to the skin with a suture. ing. In addition, a hub 15 for connecting to a line such as an extracorporeal circulation circuit, a syringe, or the like is provided on a tube connected to the proximal side tube of the inner power catheter 2 and the side injection section 14 of the outer catheter 1. And a clamp 16 to temporarily block the lumen.

Also, as shown in Fig. 17, the outer catheter can be used repeatedly for a long period of time. It is also possible to adopt a structure in which 15 parts can be removed and replaced. In this case, the outer catheter 1 is composed of a thread hook portion 13, a clamp tube portion 12, and a connector part 11.

The number, length, and number of lumens of the inner catheter are selected according to the purpose. For example, when used as a catheter for central parenteral nutrition, the infusion is administered to an inner catheter. On the other hand, when used for extracorporeal circulation such as blood purification, as shown in Fig. 1A and Fig. 1B, two inner catheters (21 and 22) with different lengths for blood removal are used. Can be connected to circulate blood.

In addition, the inner catheter 2 has pulse pressure and blood flow through its lumen. Various sensors for the amount and the like and electrodes for cardiac pacing may be mounted. Such an intravascular indwelling catheter can also be used for therapeutic use and diagnostic use. Examples of the sensor include a metal wire sensor embedded in a lumen of a catheter and sensing an electric signal or the like.

Taking a thermodilution catheter as an example, when measuring the blood flow, the temperature dilution of the blood when the ice-cold physiological saline is poured from the proximal side of the catheter and the temperature is measured by the sensor at the tip side Measured by As for pressure measurement, there is a method in which air is injected into a balloon provided at the tip of the catheter, and the pressure applied to the balloon is measured by a pressure sensor at hand.

Electrodes for cardiac pacing are provided at two points on the distal end of the catheter and on the proximal side. The electrodes are connected to an external pacemaker generator outside the body to perform pacing.

For the shape of the clamp 16, use a pinch type that closes the tube by pressing it with a finger, or a slit type that closes the tube by sliding a slit into a plate-shaped object with a gradually decreasing width. The shape is not particularly limited as long as it has a function of closing the tube.

In addition, as shown in FIG. 2B, it is preferable to adopt a check valve structure 18 that minimizes the leakage of blood outside the body when the inner catheter 2 or the obturator 13 is attached. Can also be used. The structure of the check valve may be, for example, a layer with a thickness of elastic rubber containing a slit, but the material and structure are not particularly limited as long as the structure does not leak liquid such as blood. Not something.

The catheter may be made of any material that is safe and elastic when placed in the body, especially in blood vessels.Examples include polyurethane, silicone, polyvinyl chloride, polybutadiene, polyamide, and ethylene-vinyl acetate copolymer. However, polyurethane, which has the property of maintaining hardness outside the body and being flexible inside the body, is preferred.

The outer catheter 1 is in close contact with the subcutaneous tissue 8 as shown in Fig. 16. The cuff 52 having the function of causing the cuff 52 to be attached may be attached at one or more of the force table portions between the skin 7 penetration portion and the blood vessel 9 penetration portion.

The shape of the cuff includes a cotton-like fiber, a sponge-like one, a part of a force table with a raised portion, and the like.The material is a synthetic polymer such as polyester, nylon, and acrylic. Compounds or natural polymer compounds such as cotton, silk, chitin and the like. As another fitting method in the present invention, as described in b) above, a part of the adapter in which the inner catheter penetrates and is fixed one by one to the connector part of the outer catheter corresponding to each inner catheter. A method of fitting into the formed integrated connection part 20 and tightening the screws with a lock ring can be adopted. Specifically, this is shown in FIGS. 3A to 4B. 3A and 3B show the case where there are two inner catheters, and FIGS. 4A and 4B show the case where there are three inner catheters. The connection part 20 is formed on the upper part of the connector part 11 of the outer catheter 1 so as to correspond to each one of the inner force catheters 2 and is integrated with the connector part 11. A screw 19 is formed at the mouth of the connection part 20 so that the lock ring 24 is screwed. In the catheter for indwelling in a blood vessel shown in FIGS. 3A to 4B, when the inner catheter 2 is removed for cleaning or replacement, it is possible to remove the mouth ring 24 of the intended inner force catheter. As another fitting method in the present invention, as in the above c), there is a method in which the connection portion in b) is directly screwed to the connector portion 11 of the outer catheter via an attachment. Specifically, FIGS.7A to 8B show the case where two inner catheters are used in FIGS.7A and 7B, and the case where three inner catheters are used in FIGS.8A and 8B. Is shown. In this embodiment, the connection part 20 formed corresponding to each inner power catheter 2 is integrated with the attachment. The inner lumen of this attachment is threaded, and a part of the connector of the outer catheter is provided. Screwed to the mouth. Further, as another fitting method in the present invention, as described in d) above, an elastic rubber attachment having a tapered inner hole into which the Y-tube portion of the inner catheter can be inserted is partially connected to the connector of the outer catheter. Then, the inner catheter is pushed into the inner hole by a screw. Specifically, this is shown in FIGS. 9A and 9B. Attachment 6 having a structure substantially matching the shape of Y-tube portion 51 of double lumen catheter 5 disclosed in FIG. 9A can be connected to connector portion 11 of the outer catheter. By adjusting the shape of the elastic rubber layer 27, which is a part of the fitting portion of the attachment 6, to the shape of the Y-tube portion 51 of each catheter to be mounted, catheters having various shapes can be formed according to the present invention. One catheter 1 can be connected. By devising an attachment for connecting the outer catheter 1 and the inner catheter 2, a structure in which the length of the inner catheter can be finely adjusted while connected to the outer catheter 1 can be employed.

As one example, FIGS. 1OA and 10B show the attachment body as a threaded structure 53, and the lock ring 24 fitted thereto is rotated to fit the outer catheter 1. Are shown to adjust In addition, there is a method of rotating the lock ring portion 24 of the adapter portion 23 of the inner catheter 2 to adjust the length of the attachment.

Fine adjustment of the length of the inner catheter is performed for the purpose of changing the tip of the catheter to a position where it does not contact the blood vessel wall, etc., but the length of the fine adjustment is preferably within 5 cm, More preferably, the function is performed in the range of cm. Other methods for fine-tuning the length of the inner catheter include bellows-type attachments 54 as shown in FIGS. 11A and 11B, as well as those shown in FIGS. 12A and 12B. It may be a combination of multiple detachable attachments 55, and adjust the length while tightening the lock ring as shown in Figs.13A to 13D. Attachment 5 6 to fix and fix. The range of the fine adjustment of the length is as described above. As a method for finely adjusting the length of the inner catheter, in addition to the above attachment, the structure of the attachment may be integrated with the connector portion of the outer catheter 1. In order to prevent the formation of a thrombus in the lumen of the outer catheter and blockage when the inner catheter 2 is not used, an obturator (inner plug) as shown in Fig. Can also be attached.

The structure of the obturator 3 only needs to have the structure of a rod-shaped obturator main body 31 having a thickness to close the inner lumen of the outer catheter and an adapter 23 to be attached to the outer catheter 1. The structure of the adapter 23 may be basically the same as that of the inner catheter 2. On the other hand, it is also possible to fill the lumen of the catheter 1 with an anticoagulant such as heparin without using the obturator 3, but if a thrombus is formed, one example is shown in FIG. It is also possible to physically remove or collect a thrombus by attaching a device 4 for removing or collecting a thrombus as shown in 15.

An example of the structure of a device for removing or collecting a thrombus is a loop-shaped wire portion 41 for grasping an object such as a thrombus, but the shape of the wire portion 41 is to remove or collect a thrombus. There is no particular limitation as long as it has a structure that allows it. There is also an operation part 42 for actually putting the wire part 41 in and out of the catheter, and an adapter part 23 for fitting the connector part 11 of the outer catheter. The structure of the adapter part 23 may be basically the same as that of the inner catheter 2.

Further, the structure of the device 4 for removing or collecting thrombus may be a method of removing or collecting thrombus by suction force, instead of the wire shape. The intravascular indwelling catheter of the present invention may be subjected to an antithrombotic treatment in order to prevent formation of a thrombus due to contact with blood during indwelling.

For the antithrombotic treatment, a method of immobilizing plasminogen activator such as perokinase on the surface of the base catheter by a chemical bonding method (for details, see Patent No. 1406803). Various methods have been developed, such as a method of coating a catheter surface with an anticoagulant factor such as palin, but the method is not limited to a specific method.

In addition, the range of the antithrombotic treatment may be the outer surface, the inner surface, or both of the catheter as long as the portion comes into contact with blood.

The catheter for indwelling in the blood vessel according to the present invention includes an antibacterial agent, an antibiotic, or the like on the entire or part of the surface of the force sensor of the base material to prevent infection with bacteria, fungi, viruses, and the like during the indwelling of the catheter. (See, for example, JP-A-2001-276210) and those in which an antibacterial agent is directly kneaded into a substrate (for example, see JP-A-8-157). 641).

The catheter for indwelling in a blood vessel of the present invention has been subjected to a lubricating treatment such as coating the surface of a base material with a hydrophilic polymer compound in order to facilitate penetration into a subcutaneous tissue or a blood vessel (for example, And Japanese Patent Application Laid-Open No. 10-248919. Many methods have been developed for lubricating treatment, but any method may be selected. The range of the lubricating treatment may be any part as long as it is a part that comes into contact with the human body or a part that comes into contact with a tool for placing the force catheter.

Although the present invention has been described in detail and with reference to specific embodiments, it will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the invention.

This application is based on 13 patent applications filed on June 10, 2004 (Japanese Patent Application No. 2004-172729), the contents of which are incorporated herein by reference. Industrial applicability

One or more embodiments of the present invention can selectively mount one inner catheter indwelled in a blood vessel to a catheter and a shape suitable for various purposes and a number of inner catheters. In the event of occurrence of an insufficiency, a new inner catheter with a different length or thickness can be easily replaced as many times as necessary, and as a result, a catheter for indwelling indwelling that can be indwelled continuously for a long period of time is provided. I do. In particular, since catheters can be used continuously until the end of the purpose, unless there is a problem with the catheter itself, such as for central parenteral nutrition, which is used over a long period of one month or one year Useful for various purposes.

7

Claims

1. An outer catheter,

An inner catheter that is inserted into the lumen of the outer catheter and detachably fits with the outer force table.

The inner catheter is composed of two or more single-layer lumen catheters, or one or two or more multi-layer lumen catheters,

Blue

Force for indwelling in a blood vessel. of

2. Two or more single-layer lumen catheters or multiple-layer lumen catheters that constitute the inner catheter are each separately detachable,

2. The intravascular indwelling catheter according to claim 1.

3. A therapeutic or diagnostic sensor is mounted through the lumen of the inner catheter.

2. The intravascular indwelling catheter according to claim 1.

4. A therapeutic or diagnostic sensor is mounted through the lumen of the inner catheter.

The force catheter for indwelling in a blood vessel according to claim 2.

5. The electrode for the cardiac pacemaker is attached through the lumen of the inner catheter,

2. The intravascular indwelling catheter according to claim 1.

6. The electrode for the cardiac pacemaker is attached through the lumen of the inner catheter.

3. The intravascular indwelling catheter according to claim 2.

7.

A connector part provided on the arter catheter,

A plurality of connecting portions integrated with the connector and provided on an upper part of the connector;

A screw provided at each of the connection portions,

A mouth ring provided on each of the inner catheters and screwed together with the screw,

The catheter for indwelling in a blood vessel according to claim 1, comprising:

8. Furthermore,

A connector provided on the outer catheter,

Attachment screwed to the connector part,

A plurality of connecting portions provided integrally with the attachment;

Consisting of

Each of the inner catheters is connected to the catheter via the connection portion.

2. The intravascular indwelling catheter according to claim 1.

9.

A connector provided on the outer catheter,

A Y-tube portion provided on the inner catheter and screwed to a part of the connector;

The catheter for indwelling in a blood vessel according to claim 1, comprising:

1 0.

An attachment for connecting the outer catheter and the inner catheter, The catheter for indwelling in a blood vessel according to claim 1, wherein the attachment has a screw structure whose length is adjustable.

1 1.

The outer catheter and the inner catheter are connected to each other, and a bellows-type attachment whose length is adjustable,

2. The intravascular indwelling catheter according to claim 1.

1 2.

A plurality of detachable attachments for connecting the outer catheter and the inner catheter,

By changing the number of attachments of the detachable attachment, the entire length of the attachment can be adjusted,

2. The intravascular indwelling catheter according to claim 1.