WO2005117923A1 - Bioprotection - Google Patents

Bioprotection Download PDF

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Publication number
WO2005117923A1
WO2005117923A1 PCT/EP2005/005547 EP2005005547W WO2005117923A1 WO 2005117923 A1 WO2005117923 A1 WO 2005117923A1 EP 2005005547 W EP2005005547 W EP 2005005547W WO 2005117923 A1 WO2005117923 A1 WO 2005117923A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
aquaculture
aquatic organisms
brevibacillus parabrevis
parabrevis
Prior art date
Application number
PCT/EP2005/005547
Other languages
German (de)
English (en)
Inventor
Björn-Oliver JACKISCH
Arno Cordes
Original Assignee
Süd-Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Süd-Chemie AG filed Critical Süd-Chemie AG
Priority to BRPI0511563-9A priority Critical patent/BRPI0511563A/pt
Priority to MXPA06013619A priority patent/MXPA06013619A/es
Publication of WO2005117923A1 publication Critical patent/WO2005117923A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the invention relates to a method for promoting health, in particular for combating and / or preventing diseases of aquatic organisms, using a composition which contains at least one brevibacillus parabrevis bacterium. Also described are additives containing at least one brevibacillus parabrevis bacterium and their preferred use.
  • the culture density i.e. maximizes the number of living things produced per unit area.
  • Increasing culture densities go hand in hand both in water and on land with an increasing exposure to - often pathogenic - microorganisms.
  • the use of fresh and / or live feed e.g. Cuttlefish, polychaete, Artemia nauplia or microalgae, especially in the early culture phases of the production of aquatic organisms, additional pathogenic microorganisms that adhere to the feed are introduced into the culture environment.
  • the constant presence of nutrient-rich feed in the culture tanks is ideal for the growth of bacteria.
  • Antibiotics are used therapeutically and prophylactically in considerable amounts to minimize the contamination of the cultural environment with microorganisms.
  • the use of antibiotics is of great importance in the discussion about the negative effects of aquaculture. Two aspects in particular are discussed: on the one hand the introduction of antibiotics into the food chain and on the other hand the formation of antibiotic-resistant microorganisms with all their implications, especially with regard to increasing their pathogenicity potential.
  • the antibiotics used in aquaculture can be divided into four groups according to their mode of action.
  • this is a group of substances that inhibit cell wall synthesis (penicillins and cephalosporins).
  • This group includes, for example, penicillin, ampicillin, cefuroxi, Cefaclor, Vancomycin or Bacitracin.
  • the second group includes substances that inhibit protein synthesis. It includes substances such as gentamycin, kanamycin, streptomycin, tetracycline, chloramphenicol or erythromycin.
  • Inhibitors of nucleic acid synthesis such as sulphametizol, trimethoprim or nalidixic acid represent the third group.
  • the fourth group includes substances which are thought to have an antimicrobial effect, but whose mechanism of action is not exactly understood. This includes, for example, inhibitory furanones (see, for example, WO 02/47681 for a comprehensive description of the use of these substances for controlling pathogenic organisms).
  • WO 03/103692 also describes the production and use of zooplankton, which is enriched with probiotics and prebiotics.
  • the absorption and digestion of the carrier organisms mediate a direct release of the active substances in the target organism. It should be noted that this method is very complex and is also associated with a transition of the antibiotics into the food chain.
  • the use of ozone to reduce the microbial load in aquacultures is also known from the scientific literature (Colberg & Lingg (1978) Fish. Res. Board Can. 35, 1290-1296; Wedemeyer et al. (1979) J. Fish. Res Board Can. 36, 605-614; Liltved et al. (1995) Aquac. Eng.
  • probiotics Another path that has been taken to control pathogenic microorganisms in animal production and in humans is the use of so-called probiotics.
  • the latter are defined as living microorganisms which, when ingested by an animal or by humans, have beneficial effects on the target organism in question.
  • the positive effects of probiotics are conveyed, for example, by immunostimulatory effects or anti-microbial properties.
  • probiotics are able to displace pathogenic microorganisms through competitive exclusion, for example through competition for food sources or settlement areas.
  • a further discrimination of probiotics into endo-probiotics and exo-probiotics can be made: the former have positive effects after being absorbed by the target organism, for example by settling and acting in the gastrointestinal tract of the target organism or stimulating special specific or non-specific immune responses, the latter causing these effects by settling in the environment of the target organism.
  • a Lactococcus sp. Obtained from the gastrointestinal tract of the flounder, could have an inhibitory effect on a pathogenic Streptococcus sp. (Jeong et al. (2003) J. Fish. Sei. Tech. 6, 27-33).
  • Penaeus spp. Shrimp
  • Bacillus spp. and Lactobacillus spp. examined as probiotics. For example, Dalmin et al. the application of Bacillus spp. in the production of Penaeus monodon, which are particularly useful for reducing pathogenic Vijbrio spp.
  • Renpipat group Another study by the Renpipat group describes the positive effect of a mixture of Lactobacillus spp. in the pathogen / target organism system described above (Phianphak et al. (1999) J. Sei. Res. Chula. Univ. 24, 41-51).
  • WO 97/06811 describes the use of a bacteriostatic or a bacteriocidal Carnojbacterium strain for the treatment of mammals including humans, fish, shellfish and mussels.
  • WO 02/00035 describes a method for controlling or preventing disease in aquatic organisms by feeding the organisms with a composition according to the invention which contains at least one type of probiotic bacteria and at least one inhibitory or regulatory component, in particular furanones.
  • US Pat. No. 6,562,585 describes a mixture and a method for aerobic oxidation and reduction of organic and inorganic N 2 loads.
  • the bacterial composition according to the invention is selected from and limited to Bacillus spp. for the cleaning of contaminated water, waste water flows and waste water systems. The cleaning takes place in an aerobic process.
  • enzymes such as cellulases, amylases, proteases and lipases is also described.
  • the object of the present invention was therefore to provide a method and a composition which enable efficient control of important pathogens of aquatic organisms or the improvement of the health of these organisms and which avoids the disadvantages of the prior art.
  • the method according to the invention can initially be used for the (therapeutic) control or control of an aquatic disease Organisms, in particular through an infestation with pathogenic microorganisms, are used.
  • preventive use is also included, ie the composition containing Brevibacillus parabrevis can also be used in "healthy" aquatic organisms, ie before a disease or an infestation with pathogens or before disease symptoms become visible.
  • a prophylactic or preventive use of the method according to the invention can be useful in order to exclude or minimize the spread of pathogenic organisms from the outset.
  • the diseases to be treated are in particular diseases which are at least partially caused by microorganisms, in particular bacteria or viruses. Also included are diseases in which at least one or more symptoms are directly or indirectly due to the presence of such microorganisms or their metabolites.
  • Typical disease-causing microorganisms are found in aquatic organisms such as crustacea or Penaeus spec. (Shrimp) gram-negative bacteria, especially Vibrio spec. .
  • aquatic organisms such as crustacea or Penaeus spec. (Shrimp) gram-negative bacteria, especially Vibrio spec.
  • examples include V. parahaemolyticus, V. spectacularus, V. mimicus, V. cholerae, V. alginolyticus, V. anguillarum.
  • species of the bacterial genus Aeromonas are known as pathogens of aquatic organisms.
  • the method according to the invention is preferably used in aquatic organisms, but use in land organisms is also not excluded. In practice, commercial aquacultures, in particular in basins, containers, tubs, cages, aquariums, tanks, ponds or the like, will often be in the foreground. Of course, the method according to the invention is also useful in the private keeping or breeding of aquatic organisms.
  • Preferred aquatic organisms include, without limitation, crustaceans, fish, aquatic plants, mollusks and in particular Penaeus spec. (Shrimp).
  • composition used in the process according to the invention contains at least one bacterium of the brevibacillus parabrevis type. It is believed, without restricting the invention to the assumption of this theoretical mechanism of action, that Brevibacillus parabrevis acts as a particularly efficient probiotic agent.
  • the health-promoting effect on the aquatic organisms could be based on at least one of the following mechanisms, in particular on the interaction of several of the following mechanisms: a) control of pathogenic organisms by competitive exclusion, such as competition for feed and habitat; b) direct inhibition by production of bactericidal or bacteriostatic compounds against pathogenic microorganisms; c) inhibition of the expression of virulence genes or harmful metabolites in or by the pathogenic microorganisms; d) degradation of harmful metabolic products of the pathogenic microorganisms, for example by absorption or degradation of such harmful metabolic products by secreted or cellular enzymes; e) positive influence on water quality, in particular by stabilizing the sludge formation and reducing the nitrogen load of the culture medium. f) Positive influence on the immune system and the immune system of aquatic organisms, especially after absorption in the digestive tract.
  • living cells from Brevibacillus parabrevis are used in particular.
  • cells are preferably capable of reproduction in order to ensure the effect also with regard to the control of pathogenic organisms by competitive exclusion.
  • Dead or destroyed cells for example cells destroyed by heat sterilization, lysis or fragmentation or no longer capable of reproduction, would not be suitable for this.
  • the amount or concentration of the cells (cultures) of Brevibacillus parabrevis used according to the invention can vary within wide limits, but will generally preferably be at least 10 1 ', preferably at least 10 2 cells per ml of the aquaculture medium to be treated.
  • Brevibacillus parabrevis can be used together with other probiotic microorganisms, such as, for example, species of the genus Bacillus or Lactobacillus, Vibrio, Cellulomons, Pseudomonas or Bifidobacterium spp.
  • probiotic microorganisms such as, for example, species of the genus Bacillus or Lactobacillus, Vibrio, Cellulomons, Pseudomonas or Bifidobacterium spp.
  • Probiotic bacteria can be selected, for example, from strains of: Bacillus subtilis, Bacillus laterosporus, Bacillus amyloliquefaciens, Bacillus licheniformis r Bacillus azotoformans, Bacillus cir- culans, Bacillus pumilus, Bacillus firmus r Paenibacillus polymyxa, Paenibacillus macarans or Alteramonas spp., Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei r Lactobacillus casei subsp. tolerans, Lactobacillus jensenii, Bifidobacterium bifidum, Vibrio alginolyticus, Pseudomonas stutzeri.
  • compositions show particularly good results which, in addition to at least one representative of Brevibacil lus parabrevis, also contain the following additional microorganisms: Pseudomonas spp. r Cellulomonas biazotea, Bacillus spp. , Rhodopseudomonas pallustris, Nitrosomonas europaea, Nitrobacter winogradskyi.
  • compositions according to the invention not only particularly effectively inhibit or combat pathogens of aquatic organisms, but also improve the water quality and stabilize the critical sludge and nitrogen cycles in the water or Culture medium can be achieved.
  • a synergistic interaction with nitrifying organisms such as Nitrosomonas spec. and / or Nitrobacter spec. be determined.
  • pathogenic organisms such as Vibrio harveyi as the most common pathogenic bacterium in crabs, find an ideal breeding ground in the sludge sediment of aquacultures.
  • the composition according to the invention brings about a reduction in the pathogens in the sludge sediment and a reduction in the harmful sludge sediment and the nitrogen load itself, in particular in interaction with the above nitrifying agents.
  • the composition according to the invention brings about a reduction in the pathogens in the sludge sediment and a reduction in the harmful sludge sediment and the nitrogen load itself, in particular in interaction with the above nitrifying agents.
  • the following composition has proven to be particularly effective here: at least one representative of Nitrosomonas and Nitrobacter, at least one representative of the Psedomonades, at least one Bacillus spec, at least one cellulose-degrading bacterium, for example Cellulomonas spec, and at least one representative of the phototrophic bacteria, such as, for example, Rhodopseudomonas pallustris.
  • composition according to the invention in particular in aquaculture, with an increase in stocking density, does not impair the growth rate, survival rate and feed turnover rate of the aquatic organisms and the yield can be increased significantly better than without using the composition according to the invention.
  • any other additional components can be contained in the composition according to the invention, such as, for example, feed ingredients, other veterinary components such as antibiotics, fungicides or the like, vitamins, nutrients, colorants, or the like.
  • Such additives are familiar to the person skilled in the art in this field and can easily be selected depending on the aquatic organism of interest, the form of aquaculture or the desired dosage unit of the composition according to the invention and can also achieve positive effects in addition to i3revibacillus parabrevis.
  • the composition used according to the invention can be a liquid or solid composition.
  • the shape and (dosage) size of the composition can be chosen as desired, depending on the desired application.
  • a di- the aquatic organisms themselves are treated directly, for example by spraying on or applying the composition comprising Brevibacillus parabrevis, or by adding them to the water or culture medium.
  • the composition can be used in liquid or solid form or sprayed on, for example.
  • the treatment with the composition according to the invention is carried out at these locations in aquaculture.
  • the at least one brevibacillus parabrevis bacterium can be used in any form (including on a solid support material), preferably in the form of a bacterial culture, a bacterial concentrate, an inoculum, or in the form of spores or lyophilisates from Brevibacillus parabrevis.
  • the composition preferably contains viable or reproducible cells or spores of BreviJbacillus parabrevis, also in lyophilized form. If spores are used, induction of the mination, in particular by heat treatment of the composition, before introduction into the aquaculture can be useful. Parts, e.g. Cell fragments or cell extracts from Brevibacillus parabrevis can be used.
  • Brevibacillus parabrevis as such is known to the person skilled in the art and is commercially available.
  • a particularly suitable isolate (isolate 2) of Brevibacillus parabrevis was published on May 17, 2004 under the deposit number DSM 16410 on the Name of ASA Spezialenzyme GmbH, Wolfenbüttel, DE, and again on December 16, 2004 under the deposit number DSMZ 16986 in the name of Süd-Chemie AG, Kunststoff, DE, in accordance with the Budapest Treaty with DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Mascheroder Weg lb, D-38124 Braunschweig, deposited.
  • the method according to the invention comprises the following steps:
  • composition comprising at least one bacterium of the brevibacillus parabrevis type
  • composition from (a) into contact with an aquatic organism, in particular in an aquaculture.
  • the composition is metered directly into the water or the aquaculture medium, if appropriate via an existing water exchange circuit or a pump system.
  • the composition can be mixed with feed for the aquatic organisms or incorporated therein.
  • Feed and their components are known to those skilled in the art as such.
  • This enables targeted absorption by the aquatic organisms to be treated.
  • an effect as a so-called endo-probiotic after absorption by the aquatic organisms is possible, with the strengthening of the organism's immune system seems to play a role.
  • the composition according to the invention can be introduced before, during or after the cultivation of the aquatic organisms.
  • the plants are generally cleaned after the aquatic organisms have been harvested. In many cases, it may make sense to carry out the method according to the invention before a new generation of aquatic organisms is introduced into aquaculture.
  • a further aspect of the present invention relates to an aquaculture system for the cultivation or cultivation of aquatic organisms, comprising at least one bacterium of the species Brevibacillus parabrevis, preferably in a concentration of more than 10 2 germs / ml, in particular more than 10 3 / ml of the aquaculture Medium (e.g. water).
  • the aquaculture Medium e.g. water
  • compositions in particular an additive for aquacultures, containing at least one bacterium of the brevibacillus parabrevis type.
  • the additive can also be a veterinary composition or a bioprotective, i.e. a composition promoting the health of the organisms or living beings to be treated.
  • V. harveyi was always placed in a concentration of 10 3 germs (K) / ml in the nutrient medium SMW 3 and incubated with different concentrations of the respective bacterial species or combinations at 30 ° C.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Husbandry (AREA)
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  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Feed For Specific Animals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé de promotion de la santé, en particulier un procédé pour contrôler, lutter contre et/ou prévenir des maladies d'organismes aquatiques au moyen d'une composition contenant au moins une bactérie du type Brevibacillus parabrevis.
PCT/EP2005/005547 2004-05-27 2005-05-22 Bioprotection WO2005117923A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0511563-9A BRPI0511563A (pt) 2004-05-27 2005-05-22 uso de bactéria brevibacillus parabrevis, sistema de aqüicultura, aqüiculura e aditivo para a mesma
MXPA06013619A MXPA06013619A (es) 2004-05-27 2005-05-22 Agente de bioproteccion.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004025869.4 2004-05-27
DE102004025869A DE102004025869A1 (de) 2004-05-27 2004-05-27 Bioprotektivum

Publications (1)

Publication Number Publication Date
WO2005117923A1 true WO2005117923A1 (fr) 2005-12-15

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Application Number Title Priority Date Filing Date
PCT/EP2005/005547 WO2005117923A1 (fr) 2004-05-27 2005-05-22 Bioprotection

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CN (1) CN101001636A (fr)
BR (1) BRPI0511563A (fr)
DE (1) DE102004025869A1 (fr)
MX (1) MXPA06013619A (fr)
TW (1) TW200608986A (fr)
WO (1) WO2005117923A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059793A1 (fr) * 2005-11-28 2007-05-31 Süd-Chemie AG Controle de cyanobacteries
CN103320349A (zh) * 2013-05-07 2013-09-25 淮海工学院 一种芽孢杆菌s-2-6及其抑菌用途
WO2013155468A3 (fr) * 2012-04-12 2014-08-07 Dupont Nutrition Biosciences Aps Souches microbiennes et leur utilisation chez des animaux
CN106434420A (zh) * 2016-08-10 2017-02-22 环境保护部华南环境科学研究所 一种利用具有硝化功能的细菌净化海水养殖废水的方法

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JPH06181656A (ja) * 1992-12-16 1994-07-05 Ajinomoto Co Inc 魚類・甲殻類のウイルス病予防治療剤及び飼料

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WO2002000035A1 (fr) * 2000-06-23 2002-01-03 Acuabiotec Llc Complexe alimentaire bioactif, procede servant a preparer un complexe alimentaire bioactif et procede servant a lutter contre les maladies
WO2003015534A1 (fr) * 2001-08-16 2003-02-27 Norferm Da Proteine unicellulaire utilisee dans l'alimentation des poissons et crustaces
WO2004067013A1 (fr) * 2003-01-24 2004-08-12 Flora Technology Inc. Compositions et procedes pour restaurer la flore bacterienne

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GOTO KEIICHI ET AL: "Reclassification of Brevibacillus brevis strains NCIMB 13288 and DSM 6472 (=NRRL NRS-887) as Aneurinibacillus danicus sp. nov. and Brevibacillus limnophilus sp. nov.", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, vol. 54, no. Part 2, March 2004 (2004-03-01), pages 419 - 427, XP002339039, ISSN: 1466-5026 *
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059793A1 (fr) * 2005-11-28 2007-05-31 Süd-Chemie AG Controle de cyanobacteries
WO2013155468A3 (fr) * 2012-04-12 2014-08-07 Dupont Nutrition Biosciences Aps Souches microbiennes et leur utilisation chez des animaux
CN103320349A (zh) * 2013-05-07 2013-09-25 淮海工学院 一种芽孢杆菌s-2-6及其抑菌用途
CN106434420A (zh) * 2016-08-10 2017-02-22 环境保护部华南环境科学研究所 一种利用具有硝化功能的细菌净化海水养殖废水的方法

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TW200608986A (en) 2006-03-16
MXPA06013619A (es) 2007-02-28
BRPI0511563A (pt) 2008-01-02
DE102004025869A1 (de) 2005-12-22
CN101001636A (zh) 2007-07-18

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