WO2005102451A1 - Detection of diastolic heart failure - Google Patents
Detection of diastolic heart failure Download PDFInfo
- Publication number
- WO2005102451A1 WO2005102451A1 PCT/SE2004/000636 SE2004000636W WO2005102451A1 WO 2005102451 A1 WO2005102451 A1 WO 2005102451A1 SE 2004000636 W SE2004000636 W SE 2004000636W WO 2005102451 A1 WO2005102451 A1 WO 2005102451A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- patient
- pressure
- pulse
- dhf
- determining
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/3702—Physiological parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02154—Measuring pressure in heart or blood vessels by means inserted into the body by optical transmission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36564—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood pressure
Definitions
- the present invention relates to an implantable medical apparatus for detecting diastolic heart failure, DHF, comprising a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient.
- the invention also relates to a pacemaker provided with such an apparatus, and a method of detecting DHF, comprising the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient.
- DHF congestive heart failure caused by a predominant abnormality in the diastolic function
- diastolic heart failure i.e. diastolic heart failure
- CHF congestive heart failure
- One of these parameters is the relaxation or contraction time constant ⁇ of the heart chamber, ⁇ is calculated from a continuous pressure signal and is the drop in ventricular pressure at the end of systole and in the first part of diastole.
- the ⁇ parameter is thus a general parameter reflecting the relaxation process. According to an article by Dalane W.
- the exercise pulse pressure is one parameter separating systolic heart failure from diastolic heart failure.
- the purpose of the present invention is to utilize this knowledge to propose a technique for detecting DHF, preferably at an early stage when the patient still does not seem to have any symptoms, based on measurement of pulse pressure under work.
- an averaging means is provided to form an average value of pulse pressures during a plurality of cardiac cycles with said workload situation and an average value of pulse pressures measured during a plurality of cardiac cycles with the patient in rest. In this way the quality of the pulse pressure measurements is improved.
- a wireless communication means is connected to said comparison means for automatically sending the results of the comparison of measured pulse pressures with said reference values to external receiver means, or a storing means is provided for storing the results of the comparison of measured pulse pressures with said reference values.
- said pressure measuring means comprise a pressure sensor adapted for placement in right ventricle or coronary veins of the patient ' s heart, and said pressure measuring means are adapted to determine maximum and minimum pressures in a cardiac cycle. It is preferred to place the pressure sensor in the right ventricle or the coronary veins, since the pressures in these places reflect the morphology of the left ventricular or aortic pulse pressure, especially with regard to maximum and minimum pressures.
- the invention also relates to a pacemaker provided with the apparatus for detecting DHF and control means for optimising pacing therapy depending on the result of the comparison of said measured pulse pressures with said predetermined reference values.
- the pressure measuring means of the apparatus according to the invention then preferably comprises a pressure sensor connected to the pacemaker, since it can monitor the pulse pressure of its carrier for long periods. This is an advantage since evolvement of DHF is a slow process.
- An advantageous embodiment of the pacemaker according to the invention comprises a rate responsive sensor for use as activity sensor for determining the workload situation of the patient. Even the pressure sensor of the pacemaker can be used as activity sensor.
- photo-plethysmographic signals are sensed for determining the pulse pressure, since it has been discovered that photo-plethysmographic signals obtained by a sensor placed close to the tissue where a pacemaker or ICD is implanted contain information about pulse pressure.
- the measured pulse pressure is compared with a predetermined reference value, and according to an advantageous embodiment of the apparatus and the method according to the invention said pulse pressure in a cardiac cycle is measured for a predetermined workload situation and a rest situation of the patient, and the difference between said pulse pressures measured in said workload and rest situations is compared with a predetermined reference value for said difference for DHF detection.
- a condition of DHF is identified by a higher pulse pressure during workload than a patient with a systolic heart failure would have.
- the reference value for detection of DHF is preferably obtained from measurements on the patient at an early stage of the implantation period of the apparatus or pacemaker. The patient is supposed not to suffer from DHF at the time of implantation.
- pulse pressures are measured for different workloads of the patient and for the patient in rest at an early time, when the patient is not suffering from DHF, for determining said reference values.
- These pulse pressures from an early stage can also be measured for a certain period of time and typical pulse pressures during an identified workload and during rest are gathered and averaged and then stored for later use as reference values for comparison purposes. If later the measured pulse pressure, or average pulse pressure measured during several cardiac cycles, exceeds the reference value determined in this way by a prescribed amount x%, this is used as an indication of DHF.
- figurel is a diagram showing the left ventricular and aortic pressures as a function of time
- figure 2 shows a block diagram of an embodiment of a pacemaker according to the invention
- figure 3 is a flow chart illustrating the overall collection of pulse pressure data in an embodiment of the apparatus according to the invention
- figure 4 is a flow chart explaining in greater detail an example of the procedure for obtaining pulse pressure data according to the present invention.
- pulse pressure is meant the varying pressure in aorta during a cardiac cycle.
- the above-mentioned pulse pressure can be obtained from the pressure measured in the left ventricle.
- the top curve shows the left ventricular pressure and the curve below the aortic pressure as a function of time.
- the magnitude of the pressures are indicated in arbitrary units in the figure.
- the asterisks in the curves of figure 1 denote time points for the maxima and minima of the time derivative of the left ventricular pressure, dLVP/dt max and dLVP/dtmin respectively.
- the aortic pressure is close to the left ventricular pressure at this point of time.
- the pulse pressure can consequently be obtained from left ventricular pressure by subtracting the pressure at the point of dLVP/dt max from the maximum of the left ventricular pressure obtained during the mentioned period.
- FIG. 2 shows an embodiment of a pacemaker according to the invention comprising basic pacemaker circuits 20.
- a pressure sensor 2 is located in the right ventricle 18 of a patient ' s heart and connected to the pacemaker 4.
- the signals from the pressure sensor 2 are supplied to an A/D-converter 10. After A/D- conversion the time derivative of the signal is formed in a derivation unit 16.
- the time derivative of the pressure signals are filtered in the low pass filter 12 before supply to the microprocessor and supporting circuits 14.
- FIG. 1 is a flow chart illustrating an example of the overall process for collecting pulse pressure data. The development of DHF is a slow process as mentioned. A timer, at 26 in figure 3, is therefore provided for activating pulse pressure measurements on a regular basis for reducing the current drain and releasing microprocessor power.
- Collection of pulse pressure data is performed for different workloads of the patient, at 22 in figure 3.
- the collection process is activated by a timer, at 26, and therefore the process has to wait for activation by the timer before starting, at 24.
- pulse pressure data are stored in different intermediate memory locations depending on the workload of the patient, at 30. Addresses to this memory locations are obtained from a table pointed to by the workload or activity measuring unit depending on the workload or activity, at 32.
- Pulse pressure data from the intermediate memory is then stored in another memory according to the address obtained in the preceding step for later analysis, at 34 .
- the procedure of storing pulse pressure data can be performed by forming a floating mean value.
- FIG. 4 is a flow chart illustrating in greater detail the procedure for obtaining the pulse pressure.
- P max and Pmin denote temporary storages of maximum and minimum aortic pressures.
- a QRS has to be detected , at 38 in figure 4, after reset of P max and P m j n , at 36.
- Pressure samples P(i) are then stored continuously together with the time derivative dP(i)/dt for comparison, at 40.
- a certain number of contiguous samples have to exist simultaneously, so that the above-mentioned filtering of the time derivative of the pressure is in accordance with the length of the filter coefficients. Care must be taken so that the delay in the filter influences the selection of corresponding pressure samples in a timely fashion, i.e.
- Photo-plethysmographic signals from a sensor placed close to the tissue at the location of the implanted pacemaker or ICD contains information on pulse pressure.
- photo-pletysmographic signals can be used as an alternative for determining the pulse pressure.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Hospice & Palliative Care (AREA)
- Electrotherapy Devices (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04729568A EP1740266B1 (en) | 2004-04-26 | 2004-04-26 | Detection of diastolic heart failure |
DE602004020120T DE602004020120D1 (en) | 2004-04-26 | 2004-04-26 | PROOF OF DIASTOLIC HEART FAILURE |
PCT/SE2004/000636 WO2005102451A1 (en) | 2004-04-26 | 2004-04-26 | Detection of diastolic heart failure |
US10/562,109 US7483742B2 (en) | 2004-04-26 | 2004-04-26 | Detection of diastolic heart failure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SE2004/000636 WO2005102451A1 (en) | 2004-04-26 | 2004-04-26 | Detection of diastolic heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005102451A1 true WO2005102451A1 (en) | 2005-11-03 |
Family
ID=35196753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2004/000636 WO2005102451A1 (en) | 2004-04-26 | 2004-04-26 | Detection of diastolic heart failure |
Country Status (4)
Country | Link |
---|---|
US (1) | US7483742B2 (en) |
EP (1) | EP1740266B1 (en) |
DE (1) | DE602004020120D1 (en) |
WO (1) | WO2005102451A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008026970A1 (en) | 2006-08-28 | 2008-03-06 | St. Jude Medical Ab | Determining the variation over the time of a medical parameter of a human being |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7775966B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | Non-invasive pressure measurement in a fluid adjustable restrictive device |
US7699770B2 (en) | 2005-02-24 | 2010-04-20 | Ethicon Endo-Surgery, Inc. | Device for non-invasive measurement of fluid pressure in an adjustable restriction device |
US7658196B2 (en) | 2005-02-24 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device orientation |
US8066629B2 (en) | 2005-02-24 | 2011-11-29 | Ethicon Endo-Surgery, Inc. | Apparatus for adjustment and sensing of gastric band pressure |
US7775215B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device positioning and obtaining pressure data |
US8016744B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | External pressure-based gastric band adjustment system and method |
US7927270B2 (en) | 2005-02-24 | 2011-04-19 | Ethicon Endo-Surgery, Inc. | External mechanical pressure sensor for gastric band pressure measurements |
US8152710B2 (en) | 2006-04-06 | 2012-04-10 | Ethicon Endo-Surgery, Inc. | Physiological parameter analysis for an implantable restriction device and a data logger |
US8870742B2 (en) | 2006-04-06 | 2014-10-28 | Ethicon Endo-Surgery, Inc. | GUI for an implantable restriction device and a data logger |
US7946995B1 (en) * | 2006-11-09 | 2011-05-24 | Pacesetter, Inc. | Analyzing circadian variations of a hemodynamic parameter to determine an adverse cardiac condition |
US8187163B2 (en) | 2007-12-10 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Methods for implanting a gastric restriction device |
US8100870B2 (en) | 2007-12-14 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Adjustable height gastric restriction devices and methods |
US8377079B2 (en) | 2007-12-27 | 2013-02-19 | Ethicon Endo-Surgery, Inc. | Constant force mechanisms for regulating restriction devices |
US8142452B2 (en) | 2007-12-27 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8591395B2 (en) | 2008-01-28 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Gastric restriction device data handling devices and methods |
US8337389B2 (en) | 2008-01-28 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Methods and devices for diagnosing performance of a gastric restriction system |
US8192350B2 (en) | 2008-01-28 | 2012-06-05 | Ethicon Endo-Surgery, Inc. | Methods and devices for measuring impedance in a gastric restriction system |
US8221439B2 (en) | 2008-02-07 | 2012-07-17 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using kinetic motion |
US7844342B2 (en) | 2008-02-07 | 2010-11-30 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using light |
US8114345B2 (en) | 2008-02-08 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | System and method of sterilizing an implantable medical device |
US8057492B2 (en) | 2008-02-12 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Automatically adjusting band system with MEMS pump |
US8591532B2 (en) | 2008-02-12 | 2013-11-26 | Ethicon Endo-Sugery, Inc. | Automatically adjusting band system |
US8034065B2 (en) | 2008-02-26 | 2011-10-11 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8187162B2 (en) | 2008-03-06 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Reorientation port |
US8233995B2 (en) | 2008-03-06 | 2012-07-31 | Ethicon Endo-Surgery, Inc. | System and method of aligning an implantable antenna |
US20100234906A1 (en) * | 2009-03-16 | 2010-09-16 | Pacesetter, Inc. | System and method for controlling rate-adaptive pacing based on a cardiac force-frequency relation detected by an implantable medical device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0591642A1 (en) * | 1992-10-07 | 1994-04-13 | Pacesetter AB | Rate-responsive heart stimulator |
US5476483A (en) * | 1994-06-10 | 1995-12-19 | Pacesetter, Inc. | System and method for modulating the base rate during sleep for a rate-responsive cardiac pacemaker |
US6438408B1 (en) * | 2000-12-28 | 2002-08-20 | Medtronic, Inc. | Implantable medical device for monitoring congestive heart failure |
US20030204145A1 (en) * | 2002-04-30 | 2003-10-30 | Jan Manolas | Device for and method of rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile of left ventricular function at rest and with exercise |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6876881B2 (en) * | 2002-08-16 | 2005-04-05 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with respiration synchronous optimization of cardiac performance using atrial cycle length |
US7363077B1 (en) * | 2004-11-09 | 2008-04-22 | Pacesetters, Inc. | Adaptive timing interval control method for treating congestive heart failure |
-
2004
- 2004-04-26 DE DE602004020120T patent/DE602004020120D1/en not_active Expired - Lifetime
- 2004-04-26 EP EP04729568A patent/EP1740266B1/en not_active Expired - Lifetime
- 2004-04-26 US US10/562,109 patent/US7483742B2/en not_active Expired - Fee Related
- 2004-04-26 WO PCT/SE2004/000636 patent/WO2005102451A1/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0591642A1 (en) * | 1992-10-07 | 1994-04-13 | Pacesetter AB | Rate-responsive heart stimulator |
US5476483A (en) * | 1994-06-10 | 1995-12-19 | Pacesetter, Inc. | System and method for modulating the base rate during sleep for a rate-responsive cardiac pacemaker |
US6438408B1 (en) * | 2000-12-28 | 2002-08-20 | Medtronic, Inc. | Implantable medical device for monitoring congestive heart failure |
US20030204145A1 (en) * | 2002-04-30 | 2003-10-30 | Jan Manolas | Device for and method of rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile of left ventricular function at rest and with exercise |
Non-Patent Citations (1)
Title |
---|
MANDINOV L. ET AL.: "Diastolic heart failure", CARDIOVASCULAR RESEARCH, vol. 45, 2000, pages 813 - 825, XP002903833 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008026970A1 (en) | 2006-08-28 | 2008-03-06 | St. Jude Medical Ab | Determining the variation over the time of a medical parameter of a human being |
Also Published As
Publication number | Publication date |
---|---|
US20060149327A1 (en) | 2006-07-06 |
EP1740266B1 (en) | 2009-03-18 |
EP1740266A1 (en) | 2007-01-10 |
DE602004020120D1 (en) | 2009-04-30 |
US7483742B2 (en) | 2009-01-27 |
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