WO2005085169A1 - Skin lightening agents, compositions and methods - Google Patents
Skin lightening agents, compositions and methods Download PDFInfo
- Publication number
- WO2005085169A1 WO2005085169A1 PCT/EP2005/001595 EP2005001595W WO2005085169A1 WO 2005085169 A1 WO2005085169 A1 WO 2005085169A1 EP 2005001595 W EP2005001595 W EP 2005001595W WO 2005085169 A1 WO2005085169 A1 WO 2005085169A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- daim
- alkyl
- saturated
- unsaturated
- Prior art date
Links
- 0 *C(C1)c(ccc(O)c2)c2OC1=O Chemical compound *C(C1)c(ccc(O)c2)c2OC1=O 0.000 description 2
- HSHNITRMYYLLCV-UHFFFAOYSA-N CC(c(ccc(O)c1)c1O1)=CC1=O Chemical compound CC(c(ccc(O)c1)c1O1)=CC1=O HSHNITRMYYLLCV-UHFFFAOYSA-N 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Definitions
- relatively volatile solvents may also serve as carriers within compositions of the present invention.
- monohydric CrC 3 alkanols include ethyl alcohol, methyl alcohol and isopropyl alcohol.
- the amount of monohydric alkanol may range from 1 to 70%, preferably from 10 to 50%, optimally between 15 to 40% by weight of the cosmetic composition.
- Mushroom tyrosinase inhibition is indicative of reduction in melanin synthesis, thereby showing skin lightening effect.
- This experiment shows the efficacy of 5 coumarin derived resorcinol derivatives of the present invention.
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0507222A BRPI0507222B1 (en) | 2004-02-27 | 2005-02-16 | compost, cosmetic makeup, cosmetic skin whitening method, compound use and compound manufacturing process |
ES05715365.2T ES2543980T3 (en) | 2004-02-27 | 2005-02-16 | Manufacturing process of compounds derived from coumarin |
JP2007500107A JP4855382B2 (en) | 2004-02-27 | 2005-02-16 | Skin whitening agent, composition and method |
NZ549358A NZ549358A (en) | 2004-02-27 | 2005-02-16 | Skin lightening agents, compositions and methods, and synthesis from coumarin derivatives |
EP05715365.2A EP1718594B1 (en) | 2004-02-27 | 2005-02-16 | Process for making coumarin derived compounds |
AU2005219510A AU2005219510B2 (en) | 2004-02-27 | 2005-02-16 | Skin lightening agents, compositions and methods |
ZA2006/07017A ZA200607017B (en) | 2004-02-27 | 2006-08-22 | Skin lightening agents,compositions and methods |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/789,293 | 2004-02-27 | ||
US10/789,293 US7300646B2 (en) | 2004-02-27 | 2004-02-27 | Skin lightening agents, compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005085169A1 true WO2005085169A1 (en) | 2005-09-15 |
Family
ID=34887242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/001595 WO2005085169A1 (en) | 2004-02-27 | 2005-02-16 | Skin lightening agents, compositions and methods |
Country Status (10)
Country | Link |
---|---|
US (2) | US7300646B2 (en) |
EP (1) | EP1718594B1 (en) |
JP (1) | JP4855382B2 (en) |
AU (1) | AU2005219510B2 (en) |
BR (1) | BRPI0507222B1 (en) |
ES (1) | ES2543980T3 (en) |
NZ (1) | NZ549358A (en) |
TW (1) | TWI391145B (en) |
WO (1) | WO2005085169A1 (en) |
ZA (1) | ZA200607017B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011070080A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | 4- (azacycloalkyl) -benzene-1, 3 -diol derivatives as tyrosinase inhibitors and their synthesis and use thereof |
EP2529735A1 (en) | 2008-12-02 | 2012-12-05 | Galderma Research & Development | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics |
US8697726B2 (en) | 2008-12-02 | 2014-04-15 | Galderma Research & Development | 4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics |
US9655833B2 (en) | 2009-07-29 | 2017-05-23 | Elise OLSEN | Compositions and methods for inhibiting hair growth |
FR3045039A1 (en) * | 2015-12-15 | 2017-06-16 | Oreal | RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE |
WO2018220020A2 (en) | 2017-05-31 | 2018-12-06 | L'oreal | Resorcinol derivatives for their cosmetic use |
US10457619B2 (en) | 2015-12-16 | 2019-10-29 | L'oreal | Resorcinol derivatives for cosmetic use thereof |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7300646B2 (en) * | 2004-02-27 | 2007-11-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
US7365125B2 (en) * | 2004-08-16 | 2008-04-29 | General Electric Company | Polycarbonate compositions, articles, and method of manufacture |
WO2011084703A2 (en) * | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
US20090263513A1 (en) * | 2008-04-18 | 2009-10-22 | Jan Marini | Cosmetic skin lightening formulation |
US9044623B2 (en) * | 2009-01-27 | 2015-06-02 | Isp Investments Inc. | Polymer-bound UV absorbers in personal care compositions |
WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
KR101457370B1 (en) * | 2012-09-06 | 2014-11-03 | (주)에이씨티 | Novel derivatives of benzene diol compound, and cosmetic composition comprising the same |
CA2902506A1 (en) | 2013-03-08 | 2014-09-12 | Unilever Plc | Resorcinol compounds for dermatological use |
WO2017025105A1 (en) * | 2015-08-12 | 2017-02-16 | Nmetics Ivs | 3-(4-hydroxyphenyl)propanoic acid amide for use in tissue repair and/or skin brightening |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959393A (en) * | 1988-05-09 | 1990-09-25 | Kuraray Company, Ltd. | Skin depigmental agent |
EP0623339A1 (en) * | 1993-04-29 | 1994-11-09 | L'oreal | Use of 4-,4- and 5-, or 4- and 6-substituted derivatives of resorcin in cosmetic or dermopharmaceutical compositions for depigmentation |
JPH10316641A (en) * | 1997-03-14 | 1998-12-02 | Sankyo Co Ltd | Carboxylic acid derivative |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1581428A (en) | 1978-03-13 | 1980-12-10 | Conoco Inc | Alkylation of aromatic hydroxy compounds |
EP0071570A1 (en) * | 1981-06-19 | 1983-02-09 | Ciba-Geigy Ag | Process for the production of a photographic black dye image |
BR9803596A (en) | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivatives of resorcinol. |
JP4004182B2 (en) | 1999-05-24 | 2007-11-07 | ポーラ化成工業株式会社 | Emulsified composition |
JP4015781B2 (en) | 1999-06-28 | 2007-11-28 | ポーラ化成工業株式会社 | Emulsified composition |
EP1134207A1 (en) * | 2000-03-15 | 2001-09-19 | Pfizer Products Inc. | Process for preparing resorcinol derivatives |
US6852310B2 (en) | 2002-08-23 | 2005-02-08 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
US7300646B2 (en) | 2004-02-27 | 2007-11-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
-
2004
- 2004-02-27 US US10/789,293 patent/US7300646B2/en active Active
-
2005
- 2005-02-16 BR BRPI0507222A patent/BRPI0507222B1/en not_active IP Right Cessation
- 2005-02-16 JP JP2007500107A patent/JP4855382B2/en active Active
- 2005-02-16 AU AU2005219510A patent/AU2005219510B2/en not_active Ceased
- 2005-02-16 EP EP05715365.2A patent/EP1718594B1/en active Active
- 2005-02-16 WO PCT/EP2005/001595 patent/WO2005085169A1/en active Application Filing
- 2005-02-16 NZ NZ549358A patent/NZ549358A/en unknown
- 2005-02-16 ES ES05715365.2T patent/ES2543980T3/en active Active
- 2005-02-25 TW TW094105889A patent/TWI391145B/en not_active IP Right Cessation
-
2006
- 2006-08-22 ZA ZA2006/07017A patent/ZA200607017B/en unknown
-
2007
- 2007-10-22 US US11/875,994 patent/US7723537B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959393A (en) * | 1988-05-09 | 1990-09-25 | Kuraray Company, Ltd. | Skin depigmental agent |
EP0623339A1 (en) * | 1993-04-29 | 1994-11-09 | L'oreal | Use of 4-,4- and 5-, or 4- and 6-substituted derivatives of resorcin in cosmetic or dermopharmaceutical compositions for depigmentation |
JPH10316641A (en) * | 1997-03-14 | 1998-12-02 | Sankyo Co Ltd | Carboxylic acid derivative |
Non-Patent Citations (5)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YOSHIDA, AKIRA ET AL: "Preparation and formulation of carboxylic acid derivatives as apolipoprotein A-I secretion promoters", XP002332989, retrieved from STN Database accession no. 1998:779475 * |
E. H. WOODRUFF: "Phenylethylamines IV. Dimethoxy and Dihydroxyphenyl-n-propylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 64, 1942, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 2859 - 2862, XP002332987 * |
KOICHI HIRAI ET AL.: "Enantioselective Synthesis of the Key Intermediate of the Acyl-CoA: Cholesterol Acyltransferase (ACAT) Inhibitor", CHEMICAL AND PHARMACEUTICAL BULLETIN., vol. 48, no. 10, 2000, JPPHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., pages 1567 - 1569, XP002332986 * |
L. JALANDER: "Substituent Effects in the Reaction of t-Butylmagnesium Chloride with Substituted Ethyl Cinnamates.", ACTA CHEMICA SCANDINAVICA. SERIES B - ORGANIC CHEMISTRY AND BIOCHEMISTRY., vol. 35, 1981, DKMUNKSGAARD. COPENHAGEN., pages 419 - 428, XP002332988 * |
WOO L W L ET AL: "Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 7, 26 March 1998 (1998-03-26), pages 1068 - 1083, XP002162181, ISSN: 0022-2623 * |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2529735A1 (en) | 2008-12-02 | 2012-12-05 | Galderma Research & Development | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics |
US8697726B2 (en) | 2008-12-02 | 2014-04-15 | Galderma Research & Development | 4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics |
US8993596B2 (en) | 2008-12-02 | 2015-03-31 | Galderma Research & Development | 4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics |
EP2907804A1 (en) | 2008-12-02 | 2015-08-19 | Galderma Research & Development | Novel 4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics |
US10159634B2 (en) | 2009-07-29 | 2018-12-25 | Elise A. Olsen | Compositions and methods for inhibiting hair growth |
US9655833B2 (en) | 2009-07-29 | 2017-05-23 | Elise OLSEN | Compositions and methods for inhibiting hair growth |
EP3871671A2 (en) | 2009-07-29 | 2021-09-01 | Olsen, Elise | Fp receptor antagonists for inhibiting hair growth |
US9707169B2 (en) | 2009-07-29 | 2017-07-18 | Elise OLSEN | Compositions and methods for inhibiting hair growth |
WO2011070080A1 (en) | 2009-12-10 | 2011-06-16 | Galderma Research & Development | 4- (azacycloalkyl) -benzene-1, 3 -diol derivatives as tyrosinase inhibitors and their synthesis and use thereof |
FR3045039A1 (en) * | 2015-12-15 | 2017-06-16 | Oreal | RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE |
WO2017102802A1 (en) | 2015-12-15 | 2017-06-22 | L'oreal | Resorcinol derivatives for their cosmetic use |
US10457619B2 (en) | 2015-12-16 | 2019-10-29 | L'oreal | Resorcinol derivatives for cosmetic use thereof |
WO2018220020A2 (en) | 2017-05-31 | 2018-12-06 | L'oreal | Resorcinol derivatives for their cosmetic use |
US11401236B2 (en) | 2017-05-31 | 2022-08-02 | L'oreal | Resorcinol derivatives for their cosmetic use |
Also Published As
Publication number | Publication date |
---|---|
BRPI0507222A (en) | 2007-06-19 |
ZA200607017B (en) | 2008-04-30 |
US20080039636A1 (en) | 2008-02-14 |
BRPI0507222B1 (en) | 2015-09-08 |
AU2005219510B2 (en) | 2008-05-15 |
US7300646B2 (en) | 2007-11-27 |
EP1718594A1 (en) | 2006-11-08 |
US20050191250A1 (en) | 2005-09-01 |
AU2005219510A1 (en) | 2005-09-15 |
TWI391145B (en) | 2013-04-01 |
ES2543980T3 (en) | 2015-08-26 |
TW200531706A (en) | 2005-10-01 |
JP2007523932A (en) | 2007-08-23 |
JP4855382B2 (en) | 2012-01-18 |
NZ549358A (en) | 2010-01-29 |
US7723537B2 (en) | 2010-05-25 |
EP1718594B1 (en) | 2015-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7723537B2 (en) | Skin lightening agents, compositions and methods | |
US6852310B2 (en) | Skin lightening agents, compositions and methods | |
KR101252315B1 (en) | Novel resorcinol derivatives for skin | |
US6875425B2 (en) | Skin lightening agents, compositions and methods | |
AU2007234130B2 (en) | Skin lightening agents, compositions and methods | |
US20090175812A1 (en) | Novel Skin Lightening Agents, Compositions and Methods | |
CA2645759C (en) | Skin lightening agents, compositions and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2005715365 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006/07017 Country of ref document: ZA Ref document number: 549358 Country of ref document: NZ Ref document number: 200607017 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 999/MUMNP/2006 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007500107 Country of ref document: JP Ref document number: 2005219510 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2005219510 Country of ref document: AU Date of ref document: 20050216 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2005219510 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2005715365 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0507222 Country of ref document: BR |