WO2005070429A1 - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist - Google Patents
Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist Download PDFInfo
- Publication number
- WO2005070429A1 WO2005070429A1 PCT/EP2005/000167 EP2005000167W WO2005070429A1 WO 2005070429 A1 WO2005070429 A1 WO 2005070429A1 EP 2005000167 W EP2005000167 W EP 2005000167W WO 2005070429 A1 WO2005070429 A1 WO 2005070429A1
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- WIPO (PCT)
- Prior art keywords
- alkyl
- dementia
- group
- alkynyl
- pharmaceutically acceptable
- Prior art date
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- FVUBJBBQRWAXMG-UHFFFAOYSA-N CC(C1)(CC(C)(C2)C3)C2C1(C1)C31N Chemical compound CC(C1)(CC(C)(C2)C3)C2C1(C1)C31N FVUBJBBQRWAXMG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Definitions
- composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
- the present invention relates to a combination of a monoamine neurotransmitter re-uptake inhibitor and an antagonist, and the use of the combination in treating neurodegenerative conditions such as dementia of Alzheimer type, cerebrovascular disease and depression.
- Dementia of Alzheimer type is an insufficiently understood neurodegenerative condition mainly affecting the elderly but also younger people who are mainly genetically pre- dispositioned to it.
- One postulated method of treatment comprises the administration of antagonists of NMDA receptors.
- the International patent application WO 97/30997 discloses tropane derivatives, which are monoamine neurotransmitter re-uptake inhibitor. Similar compounds are known from the International patent application WO 93/09814.
- the present invention provides a new and surprisingly effective combination of an NMDA receptor antagonist and for separate, sequential or simultaneous administration of any monoamine neurotransmitter re-uptake inhibitors.
- the combination provides i) lower doses to be used as expected for the single drugs, and ii) a reduction or minimization of the adverse event profile of each single drug which increases general tolerability and compliance of both substances and decrease any adverse side effects as the profile of each substance is totally different due to the different mechanism of action.
- the invention relates to a pharmaceutical composition
- a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (l) j and at least one NMDA receptor antagonists or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (2), and a pharmaceutically acceptable carrier or excipient, and optionally one or more other therapeutic ingredients.
- the present invention provides a greater than expected improvement in the condition of subjects suffering from a neurodegenerative disorder with an associated cognitive deficit, such as dementia of Alzheimer type, Lewis body dementia, fronto-temporal dementia, or from a cognitive deficit which may arise from a normal process such as aging like cerebrovascular dementia, multi-infarct dementia and milder forms as age associated memory impairment (AAMI) or mild cognitive impairment (MCI) or from an abnormal process such as injury, than would be expected from administration of the active ingredients alone.
- AAMI age associated memory impairment
- MCI mild cognitive impairment
- the combination allows for a lower overall dose of each of the active ingredients to be administered thus reducing side effects and decreasing any reduction in the effectiveness of each of the active ingredients over time.
- kit of parts comprising at least two separate unit dosage forms (A) and (B): (A) one of which comprises a composition a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1), and optionally a pharmaceutically acceptable carrier; (B) one of which comprises a composition containing one or more NMDA receptor antagonists or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (2), and optionally a pharmaceutically acceptable carrier, for simultaneous, sequential or separate administration.
- A one of which comprises a composition a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1), and optionally a pharmaceutically acceptable carrier
- B one of which comprises a composition containing one or
- a combination of a monoamine neurotransmitter re- uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1) and at least one NMDA receptor antagonist or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (2) in a combined form, or separately or separately and sequentially, wherein the sequential administration is close in time or remote in time, for the manufacture of a medicamentation for the prevention or treatment of a disease or a disorder, which is responsive to the inhibition of monoamine neurotransmitter re-uptake and or to NMDA inhibition.
- a method of prevention or treatment of a disease or disorder, which disease or disorder is responsive to the inhibition of monoamine neurotransmitter re- uptake comprises administration of effective amounts of a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1) and at least one NMDA receptor antagonist or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (2) to a patient in need thereof in a combined form, or separately or separately and sequentially wherein the sequential administration is close in time or remote in time.
- a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1) and at least one NMDA receptor antagonist or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (2) to
- the monoamine neurotransmitter re-uptake inhibitor comprising a 2,3- disubstituted tropane moiety are compounds of the general formula (I)
- R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl
- R 3 is CH 2 -X-R, wherein X is O, S, or NR"; wherein R" is hydrogen or alkyl
- R' is alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkylalkyl, or-CO-alkyl
- heteroaryl which may be substituted one or more times with alkyl, cycloalkyl, or cycloalkylalkyl
- phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, alkyl, alkenyl,alkynyl, amino, nitro, and heteroaryl; phenylphenyl; pyridyl which
- R 3 is l,2,4-oxadiazol-3-yl which may by substituted in the 5 position with alkyl, cycloalkyl, or cycloalkylalkyl; phenyl which may be substituted one or more times with substituents selected fro the group consisting ofhalogen, CF 3 , CN, alkoxy, alkyl, alkenyl, alkynyl, amino, nitro, and heteroaryl; phenylphenyl; or benzyl which may be substituted one or more times with substituents selected from the group consisting ofhalogen, CF 3 , CN, alkoxy, alkyl, alkenyl, alkynyl, amino, nitro, and heteroaryl; or l,2,4-oxadiazol-5-yl which may by substituted in the 3 position with alkyl, cycloalkyl, or cycloalkylalkyl; phenyl which may be substituted in the 5 position with alkyl, cycl
- R is .CH 2 -X-R', wherein X is O, S, or NR"; wherein R" is hydrogen or alkyl ; and R' is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, or-CO-alkyl.
- R 4 is phenyl, which is substituted once or twice with substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalk yl, alkenyl, alkynyl, amino, nitro, and heteroaryl.
- R 4 is phenyl substituted once or twice with chlorine.
- the tropane derivative having dopamine reuptake inhibitor activity is a (1 R, 2R, 3S) -2, 3-disubstituted tropane derivative of formula I.
- the tropane derivative having dopamine reuptake inhibitory activity is a compound of general formula I wherein R is hydrogen, methyl, ethyl or propyl.
- the tropane derivative having dopamine reuptake inhibitory activity is a compound of general formula I whereinR 4 is 3,4-dichlorophenyl.
- those monoamine neurotransmitter re-uptake inhibitor comprising a 2,3- disubstituted tropane moiety are compounds of formula (II)
- R represents a hydrogen atom or a C 1-6 alkyl group, preferably a hydrogen atom, a methyl or an ethyl group;
- R 5 each independently represents a halogen atom or a CF 3 or cyano group, preferably a fluorine, chlorine or bromine atom;
- R represents a hydrogen atom or a C 1-6 alkyl or C 3-6 -cycloalkyl-C 1-3 -alkyl group, preferably a methyl, ethyl or n-propyl group; and m is 0 or an integer from 1 to 3, preferably 1 or 2; or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof (1 ⁇ .
- the expression" -6 alkyl includes methyl and ethyl groups, and straight- chained and branched propyl, butyl, pentyl and hexyl groups. Particular alkyl groups are methyl, ethyl, n-propyl, isopropyl and t-butyl.
- C 3-6 cycloalkyl as used herein includes cyclic propyl, butyl, pentyl and hexyl groups such as cyclopropyl and cyclohexyl.
- halogen as used herein includes fluorine, chlorine, bromine and iodine, of which fluorine and chlorine are preferred.
- physiologically functional derivative includes derivatives obtained from the compound of formula (I) under physiological conditions, these are for example N-oxides, which are formed under oxidative conditions.
- pharmaceutically acceptable acid addition salt includes those salts which are selected from among the acid addition salts formed with hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methanesulphonic acid, acetic acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid and maleic acid, the salts obtained from hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid and acetic acid being particularly preferred.
- the salts of citric acid are of particular significance.
- the tropane derivative having dopamine reuptake inhibitor activity is a compound of the general formula (I) selected from: (1 R, 2R, 3S)-2-(3-Cyclopropyl-l, 2, 4-oxadiazol-5-yl)-3- (4-fluorophenyl) tropane;
- NMDA receptor antagonists which may be used include any which are known to the skilled person and those which will become available in the future. Examples are aptiganel, budipine, eliprodil, felbamate gacyclidine, remacemide, lanicemine, memantine, midafotel, remacemide, selfotel and sinnabidol. Most preferred is a combination of the compound of formula (IA) with memantine, which is 3,5-dimethyl-l-adamantanamine of formula,
- compositions of the present invention are suitable for oral, intravenous, intravascular, inxraperitoneal, subcutaneous, intramuscular, inhalativ, topical, patch or suppository administration.
- compositions of the present invention are preferably in unit dosage forms such as tablets, pills, capsules, powders, granules, sterile parenteral solutions or suspensions, metered aerosol or liquid sprays, drops, ampoules, transdermal patches, auto- injector devices or suppositories; for oral, parenteral, intranasal, sublingual or rectal administration, or for administration by inhalation or insufflation.
- a pharmaceutical carrier e. g.
- pre-formulation compositions as homogeneous, it is meant that the active ingredient is dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules.
- This solid pre-formulation composition is then subdivided into unit dosage forms of the type described above containing from 0.05 to 10,000 mg, in particular 0.1 to about 500 mg, most preferably 0.1 to 250 mg of each active ingredient of the present invention.
- Typical unit dosage forms contain from 0.1 to 100 mg, for example 0.1, 0.5, 1, 2, 5, 10, 25, 50 or 100 mg, of each active ingredient.
- the tablets or pills of the novel composition can be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action.
- the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former.
- Trie two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permits the inner component to pass intact into the duodenum or to b e delayed in release.
- enteric layers or coatings such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol and cellulose acetate.
- cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid forms suitable for oral administration.
- liquid forms in which the novel compositions of the present invention may be incorporated for administration orally or by injection include aqueous solutions, sxiitably flavoured syrups, aqueous or oil suspensions, and flavoured emulsions with edible oils such as cottonseed oil, sesame oil, coconut oil or peanut oil, as well as elixirs and similar pharmaceutical vehicles.
- Suitable dispersing or suspending agents for aqueous suspensions include synthetic and natural gums such as tragacanth, acacia, alginate, dextran, sodium carboxymethylcellulose, methylcellulose, polyvinyl-pyrrolidone or gelatine.
- a low melting such as admixture of fatty acid glycerides or cocoa butter
- the active component is dispersed homogeneously therein, as by stirring.
- the molten homogenous mixture is then poured into convenient sized molds, allowed to cool, and thereby to solidify.
- Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate.
- Administration to the respiratory tract may also be achieved by means of an aerosol formulation in which the active ingredient is provided in a pressurised pack with a suitable propellant such as a chlorofluorocarbon (CFC) or fluorohydrocarbon (HFC) for example dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, 1,1,1,2- tetrafluoroethan (HFC-134(a) ), or 1,1,1,2,3,3,3-heptafluoroprpane, carbon dioxide, or other suitable gas.
- a suitable propellant such as a chlorofluorocarbon (CFC) or fluorohydrocarbon (HFC) for example dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, 1,1,1,2- tetrafluoroethan (HFC-134(a) ), or 1,1,1,2,3,3,3-heptafluo
- the active ingredients may be provided in the form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP).
- a powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP).
- PVP polyvinylpyrrolidone
- the powder carrier will form a gel in the nasal cavity.
- the powder composition may be presented in unit dose form for example in capsules or cartridges of, e.g., gelatine, or blister packs from which the powder may be administered by means of an inhaler.
- the compound In fonnulations intended for administration to the respiratory tract, including intranasal formulations, the compound will generally have a small particle size for example of the order of 5 microns or less. Such a particle size may be obtained by means known in the art, for example by micronization.
- a suitable dosage level is about 0.01 to 250 mg/kg per day, preferably about 0.01 to 100 mg/kg per day, and especially about 0.01 to 5 mg/kg of body weight per day of each active ingredient.
- the compounds may be administered on a regimen of 1 to 4 times per day. In some cases, however, dosage outside these limits may be used.
- composition of the invention will be used for the treatment or prevention of one or more of the following neurodegenerative conditions: pseudodementia, dementia, including dementia of Alzheimer Type, Alzheimer's disease, presenile dementia, senile dementia, Lewy-Body-dementia, Down syndrome, fronto temporal dementia, HIV related dementia, Pick's disease, cerebrovascular dementia, multi-infarct dementia, memory deficits, attention deficits, cognitive dysfunction, memory dysfunction, mild cognitive impairment (MCI), age associated memory impairment (AAMI), ageing-associated cognitive decline, age-related cognitive decline and multiple system atrophy.
- pseudodementia dementia, including dementia of Alzheimer Type, Alzheimer's disease, presenile dementia, senile dementia, Lewy-Body-dementia, Down syndrome, fronto temporal dementia, HIV related dementia, Pick's disease, cerebrovascular dementia, multi-infarct dementia, memory deficits, attention deficits, cognitive dysfunction, memory dysfunction, mild cognitive impairment (MCI), age associated memory impairment (AAMI), ageing-associated cognitive decline,
- the weight ratio of (1) to (2) ranges from 50 : 1 to 1 : 300, in particular from 1 : 1 to 1 : 200 most preferably from 1 : 2 to 1 : 100.
- Example 1 Composition of (IA) / Memantine hydrochloride film-coated tablet 0.5 mg / 5 mg
- Lactose monohydrate 200 mesh
- Microcrystalline cellulose grade PH 101
- Corn starch 6.300
- Purified water q.s.
- Sodiumstarchgrycolate 3.600
- Colloidal silicon dioxide 0.900
- Magnesium stearate 1.800
- Example 3 Composition of (IA) / Memantine bilayer tablets 0.25 mg / 4 mg
- the advantageous effect of the combination of the present invention can be shown, for example, by comparing the combined dosage of the combination with dosages of the same amount of each of the active ingredients separately on subjects using the Mini-Mental State Examination (MMSE) as described in Folstein and Folstein J. Psychiat. Res., 1975,12,189- 198 or a variant thereof as discussed in Tombaugh and Mchityre, JAGS, 1992,40,922-935.
- MMSE Mini-Mental State Examination
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006549963A JP2007518755A (en) | 2004-01-22 | 2005-01-11 | Pharmaceutical composition comprising a monoamine neurotransmitter reuptake inhibitor and an N-methyl-D-aspartate (NMDA) receptor antagonist |
EP05700805A EP1708707A1 (en) | 2004-01-22 | 2005-01-11 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
CA002554617A CA2554617A1 (en) | 2004-01-22 | 2005-01-11 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
AU2005205882A AU2005205882A1 (en) | 2004-01-22 | 2005-01-11 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04001283.3 | 2004-01-22 | ||
EP04001283 | 2004-01-22 | ||
EP04005818 | 2004-03-11 | ||
EP04005818.2 | 2004-03-11 |
Publications (1)
Publication Number | Publication Date |
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WO2005070429A1 true WO2005070429A1 (en) | 2005-08-04 |
Family
ID=34809748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/000167 WO2005070429A1 (en) | 2004-01-22 | 2005-01-11 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
Country Status (6)
Country | Link |
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US (1) | US20050182089A1 (en) |
EP (1) | EP1708707A1 (en) |
JP (1) | JP2007518755A (en) |
AU (1) | AU2005205882A1 (en) |
CA (1) | CA2554617A1 (en) |
WO (1) | WO2005070429A1 (en) |
Cited By (15)
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WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
WO2007028770A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008104580A1 (en) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
JP2009527517A (en) * | 2006-02-21 | 2009-07-30 | ヘクサル アクチェンゲゼルシャフト | Method for preparing adamantaneamines |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
EP3461819A1 (en) | 2017-09-29 | 2019-04-03 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
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MXPA06003762A (en) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor. |
MXPA06005545A (en) * | 2003-11-18 | 2006-08-17 | Boehringer Ingelheim Int | Solid pharmaceutical preparation form. |
NZ547919A (en) * | 2004-01-22 | 2009-12-24 | Neurosearch As | Compounds for the sustained reduction of body weight |
WO2009004440A2 (en) * | 2007-06-29 | 2009-01-08 | Orchid Chemicals & Pharmaceuticals Limited | Quick dissolve compositions of memantine hydrochloride |
US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
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NZ547919A (en) * | 2004-01-22 | 2009-12-24 | Neurosearch As | Compounds for the sustained reduction of body weight |
EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
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- 2005-01-11 EP EP05700805A patent/EP1708707A1/en not_active Withdrawn
- 2005-01-11 CA CA002554617A patent/CA2554617A1/en not_active Abandoned
- 2005-01-11 WO PCT/EP2005/000167 patent/WO2005070429A1/en active Application Filing
- 2005-01-11 AU AU2005205882A patent/AU2005205882A1/en not_active Abandoned
- 2005-01-11 JP JP2006549963A patent/JP2007518755A/en active Pending
- 2005-01-21 US US11/039,990 patent/US20050182089A1/en not_active Abandoned
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WO1997030997A1 (en) * | 1996-02-22 | 1997-08-28 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
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Also Published As
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AU2005205882A1 (en) | 2005-08-04 |
CA2554617A1 (en) | 2005-08-04 |
US20050182089A1 (en) | 2005-08-18 |
JP2007518755A (en) | 2007-07-12 |
EP1708707A1 (en) | 2006-10-11 |
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