WO2005069994A3 - Folate conjugates and complexes - Google Patents
Folate conjugates and complexes Download PDFInfo
- Publication number
- WO2005069994A3 WO2005069994A3 PCT/US2005/002193 US2005002193W WO2005069994A3 WO 2005069994 A3 WO2005069994 A3 WO 2005069994A3 US 2005002193 W US2005002193 W US 2005002193W WO 2005069994 A3 WO2005069994 A3 WO 2005069994A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- complexes
- conjugates
- folate conjugates
- disclosed
- therapeutic
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Immunology (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005207026A AU2005207026A1 (en) | 2004-01-22 | 2005-01-24 | Folate conjugates and complexes |
EP05722512A EP1732608A2 (en) | 2004-01-22 | 2005-01-24 | Folate conjugates and complexes |
CA002553221A CA2553221A1 (en) | 2004-01-22 | 2005-01-24 | Folate conjugates and complexes |
JP2006551370A JP2007524412A (en) | 2004-01-22 | 2005-01-24 | Folic acid conjugates and complexes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53839604P | 2004-01-22 | 2004-01-22 | |
US60/538,396 | 2004-01-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005069994A2 WO2005069994A2 (en) | 2005-08-04 |
WO2005069994A3 true WO2005069994A3 (en) | 2009-04-16 |
Family
ID=34807186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/002193 WO2005069994A2 (en) | 2004-01-22 | 2005-01-24 | Folate conjugates and complexes |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050261170A1 (en) |
EP (1) | EP1732608A2 (en) |
JP (1) | JP2007524412A (en) |
AU (1) | AU2005207026A1 (en) |
CA (1) | CA2553221A1 (en) |
WO (1) | WO2005069994A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1390077B1 (en) * | 2001-05-02 | 2014-07-16 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
EP1904183B1 (en) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Pharmaceutical composition for the treatment of osteoarthritis |
ITMC20060080A1 (en) * | 2006-06-23 | 2007-12-24 | Acom Spa | CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY. |
CN1875944B (en) * | 2006-06-29 | 2011-01-05 | 中国科学院上海药物研究所 | A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof |
NO329127B1 (en) * | 2006-09-12 | 2010-08-30 | Epitarget As | Traceable particulate material for drug delivery comprising a matrix or membrane material, a drug, and a T1 and a T2 * magnetic resonance contrast agent |
NO20064315L (en) * | 2006-09-22 | 2008-03-24 | Epitarget As | T1 MRI traceable drug delivery particles and use thereof |
EP2567711A3 (en) | 2007-02-07 | 2013-05-01 | Purdue Research Foundation | Positron emission tomography imaging method |
US20110230420A1 (en) * | 2008-11-17 | 2011-09-22 | Enzon Pharmaceuticals, Inc. | Releasable conjugates for nucleic acids delivery systems |
PL226015B1 (en) * | 2011-03-03 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | Liposome preparation containing anticancer active substance, process for the preparation thereof and pharmaceutical compositions containing thereof |
CN102526610A (en) * | 2011-12-20 | 2012-07-04 | 宋涛 | Traditional Chinese medicine for curing multiple takayasu arteritis |
US20140079636A1 (en) * | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
EP2920304B1 (en) | 2012-11-15 | 2019-03-06 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
KR101659855B1 (en) | 2014-05-08 | 2016-09-26 | 국립암센터 | Photosensitizer containing folate, and a composition for photodynamic diagnosis and therapy comprising the same |
KR101646577B1 (en) * | 2014-08-14 | 2016-08-09 | 원광대학교산학협력단 | Folate receptor targeted compound and pharmacologically acceptable salts thereof, and composition containing the same as an active ingredient for prevention, diagnosis or treatment of cancer |
WO2018067446A1 (en) | 2016-10-06 | 2018-04-12 | Duke University | Detection of cd-155, the poliovirus receptor |
WO2018075357A1 (en) * | 2016-10-17 | 2018-04-26 | Duke University | PRODUCTION OF IMMUNOTOXIN D2C7-(scdsFv)-PE38KDEL |
AU2018289349A1 (en) | 2017-06-20 | 2020-01-02 | Madrigal Pharmaceuticals, Inc. | Combination therapies comprising targeted therapeutics |
JP2020524154A (en) | 2017-06-20 | 2020-08-13 | マドリガル ファーマシューティカルズ インコーポレイテッドMadrigal Pharmaceuticals,Inc. | Targeted drug |
CN113288871B (en) * | 2021-05-28 | 2022-09-16 | 华中科技大学 | Pharmaceutical composition liposome formulations for modulation of epigenetic and immune checkpoints |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5820847A (en) * | 1989-04-03 | 1998-10-13 | Purdue Research Foundation | Method for targeting a diagnostic agent to cells |
US20030099629A1 (en) * | 1999-03-11 | 2003-05-29 | Immunomedics, Inc. | Recombinant onconase and chemical conjugates and fusion proteins of recombinant onconase |
US6653104B2 (en) * | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69719529T2 (en) * | 1996-10-17 | 2003-12-11 | Immunomedics, Inc. | NONANTANT TOXIN CONJUGATE AND FUSION PROTEIN IN AN INTERNALIZING RECEPTOR SYSTEM |
IL119627A (en) * | 1996-11-17 | 2002-03-10 | Yissum Res Dev Co | PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT |
JP3835827B2 (en) * | 1997-05-02 | 2006-10-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Immunotoxin containing onc protein against malignant cells |
US6083677A (en) * | 1998-04-29 | 2000-07-04 | Eastman Kodak Company | Photographic element containing yellow dye-forming photographic coupler |
US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
ATE460946T1 (en) * | 1998-06-22 | 2010-04-15 | Immunomedics Inc | USE OF BISPECIFIC ANTIBODIES IN DIAGNOSIS AND THERAPY |
US7138103B2 (en) * | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US7052872B1 (en) * | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
US20040043030A1 (en) * | 2001-07-31 | 2004-03-04 | Immunomedics, Inc. | Polymeric delivery systems |
US7585491B2 (en) * | 2002-12-13 | 2009-09-08 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
US20040202665A1 (en) * | 2002-07-01 | 2004-10-14 | Janette Lazarovits | Compositions and methods for therapeutic treatment |
WO2004045642A1 (en) * | 2002-11-15 | 2004-06-03 | Immunomedics, Inc. | Use of multi-specific, non-covalent complexes for targeted delivery of therapeutics |
MXPA05008222A (en) * | 2003-01-31 | 2005-10-05 | Immunomedics Inc | Methods and compositions for administering therapeutic and diagnostic agents. |
-
2005
- 2005-01-24 EP EP05722512A patent/EP1732608A2/en not_active Withdrawn
- 2005-01-24 US US11/040,114 patent/US20050261170A1/en not_active Abandoned
- 2005-01-24 JP JP2006551370A patent/JP2007524412A/en active Pending
- 2005-01-24 AU AU2005207026A patent/AU2005207026A1/en not_active Abandoned
- 2005-01-24 CA CA002553221A patent/CA2553221A1/en not_active Abandoned
- 2005-01-24 WO PCT/US2005/002193 patent/WO2005069994A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5820847A (en) * | 1989-04-03 | 1998-10-13 | Purdue Research Foundation | Method for targeting a diagnostic agent to cells |
US6653104B2 (en) * | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
US20030099629A1 (en) * | 1999-03-11 | 2003-05-29 | Immunomedics, Inc. | Recombinant onconase and chemical conjugates and fusion proteins of recombinant onconase |
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WO2005069994A2 (en) | 2005-08-04 |
CA2553221A1 (en) | 2005-08-04 |
US20050261170A1 (en) | 2005-11-24 |
EP1732608A2 (en) | 2006-12-20 |
JP2007524412A (en) | 2007-08-30 |
AU2005207026A1 (en) | 2005-08-04 |
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