WO2005069724A3 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease - Google Patents

Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease Download PDF

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Publication number
WO2005069724A3
WO2005069724A3 PCT/IB2005/001306 IB2005001306W WO2005069724A3 WO 2005069724 A3 WO2005069724 A3 WO 2005069724A3 IB 2005001306 W IB2005001306 W IB 2005001306W WO 2005069724 A3 WO2005069724 A3 WO 2005069724A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiac disease
diagnosis
assays
methods
amino acid
Prior art date
Application number
PCT/IB2005/001306
Other languages
French (fr)
Other versions
WO2005069724A2 (en
Inventor
Yossi Cohen
Alexander Diber
Amir Toporik
Sarah Pollock
Zurit Levine
Michal Ayalon-Soffer
Gad S Cojocaru
Amit Novik
Guy Kol
Osnat Sella-Tavor
Shira Walach
Shirley Sameah-Greenwald
Dvir Dahary
Ronen Shemesh
Original Assignee
Compugen Ltd
Yossi Cohen
Alexander Diber
Amir Toporik
Sarah Pollock
Zurit Levine
Michal Ayalon-Soffer
Gad S Cojocaru
Amit Novik
Guy Kol
Osnat Sella-Tavor
Shira Walach
Shirley Sameah-Greenwald
Dvir Dahary
Ronen Shemesh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compugen Ltd, Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh filed Critical Compugen Ltd
Priority to EP05726249A priority Critical patent/EP1713827A2/en
Priority to AU2005207625A priority patent/AU2005207625A1/en
Priority to CA002554585A priority patent/CA2554585A1/en
Priority to JP2006550368A priority patent/JP2007526763A/en
Priority claimed from US11/043,788 external-priority patent/US20060014166A1/en
Publication of WO2005069724A2 publication Critical patent/WO2005069724A2/en
Publication of WO2005069724A3 publication Critical patent/WO2005069724A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markets of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
PCT/IB2005/001306 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease WO2005069724A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05726249A EP1713827A2 (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
AU2005207625A AU2005207625A1 (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
CA002554585A CA2554585A1 (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
JP2006550368A JP2007526763A (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences and assays and methods using them in the diagnosis of heart disease

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US53912804P 2004-01-27 2004-01-27
US53912904P 2004-01-27 2004-01-27
US60/539,128 2004-01-27
US60/539,129 2004-01-27
US62091604P 2004-10-22 2004-10-22
US60/620,916 2004-10-22
US62113104P 2004-10-25 2004-10-25
US60/621,131 2004-10-25
US62232004P 2004-10-27 2004-10-27
US60/622,320 2004-10-27
US62819004P 2004-11-17 2004-11-17
US62813404P 2004-11-17 2004-11-17
US62812304P 2004-11-17 2004-11-17
US60/628,190 2004-11-17
US60/628,123 2004-11-17
US60/628,134 2004-11-17
US63055904P 2004-11-26 2004-11-26
US60/630,559 2004-11-26
US11/043,788 2005-01-27
US11/043,788 US20060014166A1 (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of endometriosis

Publications (2)

Publication Number Publication Date
WO2005069724A2 WO2005069724A2 (en) 2005-08-04
WO2005069724A3 true WO2005069724A3 (en) 2006-08-10

Family

ID=34812494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/001306 WO2005069724A2 (en) 2004-01-27 2005-01-27 Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease

Country Status (4)

Country Link
EP (1) EP1713827A2 (en)
AU (1) AU2005207625A1 (en)
CA (1) CA2554585A1 (en)
WO (1) WO2005069724A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090035287A1 (en) * 2005-09-26 2009-02-05 Zurit Levine Atrial natriuretic peptide (anp) splice variants and methods of using same
KR20210060670A (en) 2008-12-09 2021-05-26 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243648A1 (en) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Method for the determination of myocardial necrosis by means of antibodies against the N-terminal troponin I peptide
WO2001032927A2 (en) * 1999-11-04 2001-05-10 Incyte Genomics, Inc. Tissue specific genes of diagnostic import

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243648A1 (en) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Method for the determination of myocardial necrosis by means of antibodies against the N-terminal troponin I peptide
WO2001032927A2 (en) * 1999-11-04 2001-05-10 Incyte Genomics, Inc. Tissue specific genes of diagnostic import

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHAVSAR PANKAJ K ET AL: "Isolation and characterization of the human cardiac troponin I gene (TNN13)", GENOMICS, vol. 35, no. 1, 1996, pages 11 - 23, XP002350371, ISSN: 0888-7543 *
DATABASE EMBL 4 May 2002 (2002-05-04), XP002366938, Database accession no. BQ230791 *
SOREK R ET AL: "Alu-containing exons are alternatively spliced", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, vol. 12, no. 7, July 2002 (2002-07-01), pages 1060 - 1067, XP002336891, ISSN: 1088-9051 *
TOYOTA NAOJI ET AL: "Thin-filament-binding domains of cardiac and fast skeletal muscle troponin I isoforms as studied by epitope tagging", JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 20, no. 8, November 1999 (1999-11-01), pages 755 - 760, XP002350372, ISSN: 0142-4319 *

Also Published As

Publication number Publication date
CA2554585A1 (en) 2005-08-04
EP1713827A2 (en) 2006-10-25
WO2005069724A2 (en) 2005-08-04
AU2005207625A1 (en) 2005-08-04

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