WO2005066335A1 - Crystal structure of the interleukin-2-inducible cell kinase (itk) kinase domain - Google Patents

Crystal structure of the interleukin-2-inducible cell kinase (itk) kinase domain Download PDF

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WO2005066335A1
WO2005066335A1 PCT/US2004/043721 US2004043721W WO2005066335A1 WO 2005066335 A1 WO2005066335 A1 WO 2005066335A1 US 2004043721 W US2004043721 W US 2004043721W WO 2005066335 A1 WO2005066335 A1 WO 2005066335A1
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itk
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phe
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Joerg Martin Bentzien
Bennett Ii Farmer
Steven S. Pullen
Joey Martin Studts
Andre White
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Boehringer Ingelheim Pharmaceuticals, Inc.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Definitions

  • the field of the invention relates to kinases, particularly ITK, which are attractive targets for the treatment of human diseases.
  • kinases are key regulatory enzymes in eukaryotic signaling pathways. As such, kinases are attractive targets for pharmaceutical intervention in the treatment of human diseases.
  • Non- receptor tyrosine kinases are critically involved in transmitting signals through antigen receptors on hematopoietic cells.
  • the Src family and ZAP-70/Syk kinases function as on off switches downstream of antigen receptors
  • the Tec family of kinases plays a signal amplification role (March et al, 2002, Int J Biochem Cell Biol 34: 1184- 1189).
  • Interleukin-2-inducible T cell kinase also known as T cell-specific kinase (TSK) and expressed mainly in T cells (EMT)
  • TTK T cell-specific kinase
  • EMT T cells
  • ITK has been demonstrated to be involved in signaling tlirough the T cell receptor (TCR) (reviewed in (Miller and Berg, 2002, Curr. Opin. Immunol. 14:331-340)) and, on mast cells, the high affinity IgE receptor (Fc ⁇ RI) (Kawakami et al, 1995, J. Immunol. 155:3556-3562).
  • TCR T cell receptor
  • Fc ⁇ RI the high affinity IgE receptor
  • upstream activation of Src family and ZAP-70/Syk kinases is required for activation of ITK.
  • ITK Src kinases phosphorylate , ITK on the activation loop which is required before ITK can autophosphorylate leading to further activation (Heyeck et al, 1997, JBiol Chem 272:25401-25408). Additionally required for full activity, ITK must be recruited from the cytosol to the membrane through interactions with phosphatidyl inositol 3,4,5-trisphosphate produced upon PI3K activation and the SLP- 76/LAT complex which is phosphorylated by ZAP-70/Syk kinases. These interactions are mediated by the ITK pleckstrin homology and the SH2 domains, respectively.
  • ITK insulin receptor kinase
  • PLC- ⁇ phosphorylation of PLC- ⁇ which is required for the production of inositol 1,4,5-trisphosphate and diacylglycerol which are necessary for calcium mobilization and PKC activation, respectively, thus activating numerous downstream pathways (reviewed in (August et al, 2002, Int J Biochem Cell Biol 34: 1184- 1189)).
  • ITK In vivo studies on ITK have focused on its role in T cell development and function, hi the absence of ITK, mice have ⁇ 50% fewer CD4 T cells due to a defect in positive selection. The surviving CD4 + T cells are defective in proliferation and cytokine production upon TCR stimulation in vitro or ex vivo.
  • ITK deficient mice do not mount a Th2 response to the pathogens Leishmania major, Nippostrongylus brasiliensis, or Schistosoma mansoni in contrast to wild-type mice (Liao and Liftman, 1995, Immunity 3:757-769; Fowell et al., 1999, Immunity 11:399-409; Schaeffer et al., 2001, Nature Immunol. 2: 1183-1188). Consistent with a defective Th2 response, ITK deficient mice exhibit reduced lung inflammation, eosinophil infiltration, and mucus secretion in an allergic asthma model (Mueller and August, 2003, J. Immunol. 170:5056- 5063).
  • FIG. 1 Ribbon diagram representation of ITK/KD/G354: Compound 4 co-crystal structure. Secondary-structure elements are shown as arrows for beta-strands and as helices for alpha- helices. Compound 4 is shown with spheres for each non-hydrogen atom.
  • Figure 2 Carbon-alpha trace of ITK/KD/G354 shown in stereo projection.
  • Figure 3 Section of the electron density representation of Compound 4, shown in stereo projection. This electron density map is drawn with coefficients 2E 0 b s -Ecaic and contoured at the level of the standard deviation of the entire map.
  • Figure 4 Schematic representation of Compound 4 interactions with ITK/KD/G354. Hydrogen bonds are depicted with thick dash lines. Only Van der Waals interactions, i.e. only inter- molecular distances less than 3.8A between non-hydrogen atoms, are shown with dotted lines.
  • Figure 5 Sequence alignment of the kinase domain from human, rat, mouse and zebra fish ITK orthologs.
  • SEQ ID NO. 1 is the amino acid sequence of the human ITK kinase domain fragment
  • ITK KD/G354 used for X-ray crystallographic studies, which comprises ITK residues 354-620 of the full-length, wild-type ITK kinase (SEQ ID NO. 2). Thrombin cleavage of GST-
  • ITK/KD/G354 (SEQ ID NO. 7) produces this kinase domain fragment which contains the vector-encoded sequence glycine-serine-methionine immediately N-terminal to ITK residue glycine 354.
  • SEQ ID NO. 2 is the amino acid sequence of the full-length, wild-type human ITK kinase
  • SEQ ID NO. 3 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 343-620 of the full-length, wild-type ITK kinase, with an additional methionine encoded within the plasmid pITK/KD/Q343/GemT inserted immediately N-terminal to ITK residue glutamine 343.
  • SEQ ID NO.4 is the DNA sequence of the plasmid pGST/1393 which is a baculoviral transplacement vector derived from pVL1393 (InVitrogen Life Technologies) which is modified to contain a gene encoding glutathione-S-transferase (GST) positioned 3' to the polyhedrin promoter. DNA fragments inserted 3' to the GST gene in the multiple cloning site produce fusion proteins C-terminal to GST upon expression.
  • GST glutathione-S-transferase
  • SEQ ID NO. 5 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 343-620 (GST-ITK/KD/Q343) of the full-length, wild-type ITK kinase.
  • This GST fusion protein is encoded by the plasmid pGST-
  • SEQ ID NO. 6 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 354-620 of the full-length, wild-type ITK kinase, with an additional methionine encoded within the plasmid pITK/KD/G354/GemT inserted immediately N-terminal to ITK residue glycine 354.
  • SEQ ID NO. 7 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 354-620 (GST-ITK/KD/G354) of the full-length, wild-type ITK kinase.
  • This GST fusion protein is encoded by the plasmid pGST-
  • SEQ ID NO. 8 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 354-620 (GST-ITK KD/G354) of the full-length ITK kinase in which phenylalanine residue 437 (numbered based on its position in the full-length, wild-type human ITK kinase) is substituted with a tyrosine residue (designated GST-
  • This GST fusion protein is encoded by the plasmid pGST-
  • SEQ ID NO. 9 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 343-620 of the full-length, wild-type ITK kinase (SEQ ID NO.2).
  • SEQ ID NO. 10 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 361-620 of the full-length, wild-type ITK kinase, with an additional methionme encoded within the plasmid pITK/KD/S361/GemT inserted immediately N-terminal to ITK residue serine 361.
  • SEQ ID NO. 11 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 361-620 (GST-ITK KD/S361) of the full-length, wild-type ITK kinase.
  • This GST fusion protein is encoded by the plasmid pGST-
  • SEQ ID NO. 12 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 361-620 of the full-length, wild-type ITK kinase (SEQ ID NO. 2).
  • SEQ ID NO. 13 is the amino acid sequence of the full-length, wild-type murine ITK kinase
  • SEQ ID NO. 14 is the amino acid sequence of the murine ITK kinase domain fragment comprising ITK residues 353-619 of the full-length, wild-type murine ITK kinase, with an additional methionine encoded within the plasmid pmITK/KD/G353/TOPO inserted immediately N-terminal to ITK residue glycine 353.
  • SEQ ID NO. 15 is the amino acid sequence of the GST fusion protein to the murine ITK kinase domain fragment comprising ITK residues 353-619 (GST-mITK/KD/G353) of the full-length, wild-type ITK kinase.
  • This GST fusion protein is encoded by the plasmid pGST- mITK/KD/G353/1393.
  • SEQ ID NO. 16 is the amino acid sequence of the murine ITK kinase domain fragment comprising ITK residues 353-619 of the full-length, wild-type murine ITK kinase (SEQ ID NO.
  • This invention provides certain crystallized, protein kinase-ligand complexes, in particular ITK kinase domain-ligand complexes, and their structural coordinates. The structural coordinates are based on the structure of a ligand-bound ITK kinase domain complex that has now been solved and refined to a resolution 3.0 A and which reveals new structural information.
  • the invention provides a crystal of a polypeptide- ligand complex that comprises the ITK kinase domain and a ligand.
  • Preferred ITK kinase domains include ITK/KD/S361 (SEQ ID NO. 12), ITK/KD/Q343 (SEQ ID NO. 9) and ITK/KD/G354 SEQ ID NO. 1, with the most preferred being human ITK KD/G354.
  • the invention provides a crystal of a polypeptide-ligand complex that comprises the ITK kinase domain ITK KD/G353 SEQ ID NO. 16.
  • ITK kinase domains described herein are mammalian, preferably human and murine.
  • amino acids comprising the protein.
  • protein and polypeptide can be used interchangeably and are both defined as a polymer of two or more amino acids covalently linked by peptide bonds.
  • the amino acids may also be referred to by their conventional abbreviations, as shown in the Table 1 below.
  • a crystal, as defined herein below, according to the invention may take a variety of forms, all of which are included in the present invention.
  • the term 'ligand' shall be understood to include any molecule that forms a complex with an ITK kinase domain, as defined herein below, according to the invention and can be used to form a crystal of the present invention.
  • Preferred ligands include substituted benzimidazole compounds shown in Table 2 below. Analogs, positional and stereoisomer isomers thereof which provide a crystal structure are within the scope of the invention and will be apparent to those of ordinary skill in the art.
  • nucleic acids encoding the ITK kinase domain as described herein below.
  • vectors comprising said nucleic acids.
  • the nucleic acids and vectors are prepared as follows: A DNA fragment encoding amino acids 343-620 of the full-length, wild-type human ITK kinase (SEQ ID NO.
  • the BamHl to Notl ITK kinase domain encoding fragment from pITK/KD/Q343/GemT was ligated into pGST/1393 (SEQ ID NO. 4) at the same sites to generate pGST- ITK/KD/Q343/1393 which encodes a GST-ITK/KD/Q343 fusion protein (SEQ ID NO. 5).
  • SEQ ID NO. 4 A DNA fragment encoding amino acids 354-620 of the full-length, wild-type human ITK kinase (SEQ ID NO.
  • a DNA fragment encoding amino acids 361-620 of the full-length, wild-type human ITK kinase was PCR-amplified from pGST-ITK/KD/Q343/1393 using oligonucleotide pairs 5'- GGGATCCATGTCAGAGCTCACTTTTGTGC -3' and 5'-
  • the Bam ⁇ I to Notl ITK kinase domain encoding fragments from pITK/KD/G354/GemT and pITK/KD/S361/GemT were ligated into pGST/1393 at the same sites to generate pGST- ITK/KD/G354/1393 and pGST-ITK/KD/S361/1393 which encode the fusion proteins GST- 11K/KD/G354 (SEQ ID NO. 7) and GST-ITK/KD/S361 (SEQ ID NO. 11), respectively.
  • pGST- ITK/KD/G354/F437Y/1393 which, in the GST-ITK/KD/G354 construct, encodes a tyrosine in place of a phenylalanine at residue 437 of the full-length human ITK kinase sequence was generated using the complementary oligonucleotides 5'- CCTGGTGTTTGAGTACATGGAGCACGGCT-3' and 5'-
  • GGCGGCCGCCTAAAGCCCAGCTTCTGCG-3' ligated into pCRII-TOPO (hivitrogen) to make pmITK/KD/G353/TOPO wherein a methionine residue is inserted immediately N-terminal to G353 of ITK to generate the predicted protein in SEQ ID NO. 14.
  • the BamUl to Notl ITK kinase domain encoding fragment from pmITK/KD/G353/TOPO was ligated into pGST/1393 (SEQ ID NO. 4) at the same sites to generate pGST-mITK/KD/G353/1393 which encodes a GST-mITK/KD/G353 fusion protein (SEQ ID NO. 15).
  • Recombinant baculovirus stocks were generated by standard methods (O'Reilly et al, 1992, Baculovirus Expression Vectors: A Laboratory Manual W.H. Freeman & Co.) using the pGST-ITK/KD/Q343/1393, pGST- ITK/KD/G354/1393, pGST-ITK/G354/F437Y/1393, pGST-ITK/KD/S361/1393, pGST- mITK/KD/G353/1393 vectors.
  • Said polypeptides can be produced as follows: Protein expression and purification Spodoptera frugiperda (S£21) cells were maintained and infected as described previously (Dracheva et al, 1995, J Biol Chem 270:14148-14153) using medium supplemented with 5% heat-inactivated fetal bovine serum (Hyclone) and 50 ⁇ g/ l gentamicin sulfate (Life Technologies, Inc.). All purification procedures were performed at 4°C. Cytosolic extracts of baculovirus-infected Sf21 cells were prepared as described (Pullen et al, 1998, Biochemistry 37:11836-11845).
  • Extracts were applied to a glutathione sepharose 4B column (Amersham) equilibrated in Buffer A (20 mM HEPES, pH 7.5, 150 mM NaCI, 1 mM TCEP, 10% v/v glycerol, 0.1 mM EDTA, 0.1 mM EGTA, and 1 mM PMSF).
  • Buffer A 20 mM HEPES, pH 7.5, 150 mM NaCI, 1 mM TCEP, 10% v/v glycerol, 0.1 mM EDTA, 0.1 mM EGTA, and 1 mM PMSF.
  • Buffer A 20 mM HEPES, pH 7.5, 150 mM NaCI, 1 mM TCEP, 10% v/v glycerol, 0.1 mM EDTA, 0.1 mM EGTA, and 1 mM PMSF.
  • the column was washed with Buffer A containing 400 mM NaCI.
  • protein was eluted by flowing bovine thrombin (USB) at 20 units/mL onto the column in 50 mM Tris, pH 8.0, 2.5 mM CaCl 2 , 10 % v/v glycerol, and 150 mM NaCI.
  • bovine thrombin USB
  • the amino acid sequences of the resulting thrombin cleaved proteins ITK/KD/Q343, ITK/KD/G354, ITK/KD/S361, and mITK/KD/G353 are shown in SEQ ID NO. 9, SEQ ID NO. 1, SEQ ID NO. 12, and SEQ ID NO. 16, respectively.
  • Peak fractions containing the ITK kinase domain were pooled, diluted with an equal volume of Buffer B (10 mM Tris, pH 7.2, 100 mM NaCI, 5% glycerol, 0.5 mM TCEP), applied to a Macro-Prep DEAE column equilibrated in Buffer B, and proteins were eluted with a 0 to 500 mM NaCI gradient in Buffer B. Peak fractions were pooled and applied to a Sephacryl S-100 HR column preequilibrated with 10 mM HEPES, pH 7.5, 100 mM NaCI, and 1.0 mM TCEP.
  • Buffer B 10 mM Tris, pH 7.2, 100 mM NaCI, 5% glycerol, 0.5 mM TCEP
  • Peak fractions were pooled, concentrated to approximately 30 mg/ml using a Vivaspin 30 K MWCO concentrator (Sartorius), quantified, frozen in aliquots under liquid nitrogen, and stored at -80°C. Sample purity was verified by SDS-PAGE analysis and electrospray ionization mass spectrometry.
  • ITK kinase domain shall be understood to mean a polypeptide construct comprising residues 354-620 of human ITK (ITK/KD/G354) which binds a ligand as defined herein.
  • bound ligands include, but are not limited to, inhibitor small molecules. This inhibition is expressed as an IC 50 value that is determined either by the Tec Family Kinase Assay described below or by other methods known in the art to measure ⁇ M to nM IC 50 values for small-molecule inhibitors.
  • small molecule ITK inhibitors include, but are not limited to, those compounds shown in Table 2 and Compound 8.
  • ITK/KD/Q343 was subjected to limited digestion with trypsin to identify fragments of the ITK kinase domain that are resistant to proteolysis due to being folded in a more stable and compact conformation. Protein fragments were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis. Characterization of the fragments indicated that residues N-terminal to R352 are accessible to trypsin. Consequently, an ITK kinase domain construct including residues 354-620 of human ITK (ITK KD/G354) was designed to increase the stability of the protein.
  • an ITK kinase domain construct including residues 361-620 of human ITK was designed to remove all but two residues N-terminal to subdomain I of the kinase, based on the Hanks classification of protein kinases (Hanks and Hunter, 1995, FASEB J. 9:576-596), in case these are disordered in the context of the shorter ITK/KD/G354 construct.
  • ITK/KD/S361 ITK kinase domain construct including residues 361-620 of human ITK
  • the murine ITK kinase domain fragment including residues 342-619 has 3 conservative and 7 non-conservative amino acid substitutions when compared with human ITK kinase domain residues 343-620.
  • an ITK kinase domain construct including residues 353-619 of murine ITK (mITK/KD/G353) homologous to the stable human fragment (ITK/KD/G354) was designed as described in the DNA cloning and baculovirus generation section.
  • Tec Family Kinase Assay ITK is purified as a GST-fusion protein to test for catalytic activity.
  • the kinase activity is measured using DELFIA (Dissociation Enhanced Lanthanide Fluoroimmunoassay) which utilizes europium chelate-labeled anti-phosphotyrosine antibodies to detect phosphate transfer to a random polymer, poly Glu 4 : Tyri (PGTYR).
  • the screen utilizes the Zymark Allegro UHTS system to dispense reagents, buffers and samples for assay, and also to wash plates.
  • the kinase assay is performed in kinase assay buffer (50 mM HEPES, pH 7.0, 25 mM MgCl 2 , 5 mM
  • Test samples initially dissolved in DMSO at 1 mg/mL are pre-diluted for dose response (9 doses with starting final concentration of 3 ⁇ g/mL, 1 to 3 serial dilutions) with the assay buffer in 384- well polypropylene microtiter plates. A 10 ⁇ L volume/well of a mixture of substrates containing
  • IC 50 can be obtained by fitting the rates vs. compound/ligand concentration data into a simple competitive inhibitor model. Under these assay conditions, a 3-fold difference in compound potency (IC 50 ) is considered within the variation of the assay.
  • Preferred ligands will have an IC 50 ⁇ 1000 nM.
  • Thermal denaturation experiments were performed on a Jasco J-720 spectropolarimeter equipped with a Peltier thermostatic cell holder. For each measurement, a 1 cm quartz cuvette was loaded with 5 ⁇ M ITK kinase domain construct in a pH 7.0 buffer containing 10 mM sodium phosphate, 100 mM NaCI and 1 mM TCEP. Absorbance data at 230 nm was collected as the temperature was scanned from 2 to 100 °C at a ramp rate of 0.2 °C/min. The melting temperature (T m ) for each sample was calculated as the maximum deflection point of the first derivative of the melting transition using Origin (version 7.0).
  • Rational mutant design ITK/KD/G354 F437Y The ITK residues Q367, 1369, L379, K387, and F437, numbered based on the position in the full-length, wild-type human ITK kinase, define a shallow, surface-exposed hydrophobic pocket on ITK KD/G354 that has not been described in previous kinase crystal structures. The observed interaction of Compound 4 with this hydrophobic pocket region suggests that it could contribute to favorable compound interaction.
  • Phe437 extends its side chain toward Compound 4 such that the Phe C ⁇ (4-position aromatic carbon) is found in close proximity to the cyclohexyl moiety of Compound 4.
  • ITK with the F437Y substitution is inhibited less than the wild-type ITK kinase domain (GST- ITK/KD/G354) by compounds with a six-membered hydrophobic ring functionality, such as an optionally substituted aryl, heteroaryl or cycloalkyl moiety.
  • 'crystal' or 'protein crystal' shall be understood to mean a product of the process of obtaining crystals of the ITK kinase domain protein-ligand complex, with said process comprising:
  • step (b) subjecting the composition of step (a) to conditions which promote crystallization.
  • Another aspect of this invention relates to a method for preparing crystals containing an ITK kinase domain protein-ligand complex. It is inferred by those skilled in the art that a variety of techniques and suitable conditions which promote crystallization may be used to grow protein or protein-ligand crystals. This includes, but is not limited to, batch, under-oil batch, dialysis, vapor diffusion by either sitting or hanging drops, and liquid bridge (Ducruix and Geige, 1992, Crystallization of Nucleic Acids and Proteins: A practical Approach, IRL Press, Oxford, England; McPherson, 1999, Crystallization of Biological Macromolecules, Cold Spring Harbor Laboratory Press, New York).
  • any one of the above techniques may be used to grow ITK/KD/G354 crystals.
  • the vapor diffusion method is used to grow ITK/KD/G354 crystals.
  • Compound 4 is used to grow ITK/KD/G354 protein-ligand crystals by means of the vapor diffusion method.
  • hanging drops are used with the vapor diffusion method and with Compound 4 to grow ITK/KD/G354 protein-ligand crystals.
  • a most preferred crystallization protocol is disclosed in the examples section.
  • the vapor diffusion method involves the equilibration of one or more drops containing the protein formulation against a larger reservoir solution in a sealed well. These drops may be sitting or hanging.
  • the reservoir solution contains a precipitant constituent that is more concentrated than it is in the drop.
  • this precipitant is 5 to 15% polyethylene glycol 1500 (PEG 1500).
  • PEG 1500 polyethylene glycol 1500
  • 8 to 12% PEG 1500 is used.
  • a most preferred crystallization protocol is disclosed in the examples section. Such a formulation is applicable with human ITK/KD/G354-ligand, but is different when used with the murine ITK/KD/G353 -compound preparation.
  • the preferred precipitant for murine ITK/KD/G353-compound crystallization is 7 to 30% polyethylene glycol 5000 monomethylether, a more preferred precipitant being 10 to 18% polyethylene glycol 5000 monomethylether.
  • the crystallization solution pH is an important factor influencing protein crystallization. Commonly, an optimal pH is achieved by adjusting the reservoir solution pH and by using some of this solution in the protein crystallization drop.
  • the reservoir solution contains lOOmM sodium citrate pH 5 to 6.
  • the buffer solution used is first adjusted to pH 5.2-5.4, then autoclaved, at which point the buffer pH changes to values of 5.55-5.75, and finally used with the other constituents to form the reservoir solution.
  • a most preferred protocol is disclosed in the examples section. Once a crystal of the present invention is grown, it can be characterized by X-ray diffraction.
  • More than one method may be used to generate X-rays and to characterize the diffraction pattern.
  • X-rays used may be generated from a conventional source, such as a sealed tube or rotating anode, or from a synchrotron source.
  • Methods of characterization include, but are not limited to, diffractometer data collection, precession photography and Laue diffraction. Data may be processed using D*TREK (Rigaku MSC), MOSFLM (Leslie, 1999, Ada Crystallogr. D 55:1696-1702) or a combination of DENZO and SCALEPACK (Otwino ski and Minor, 1997, Meth. Enzymol. 276:307-326).
  • Examples herein provide a statistical sampling of X-ray diffraction data measurement, data reduction and analyses.
  • Crystal structure determination A structure determination using X-ray diffraction requires phase angle estimates to be combined with the diffraction data. In the case of macromolecules, such phase angle estimates may be derived from a known structure of similar topology, from ab initio using indirect methods, or a combination thereof. The former is achieved using molecular replacement methods, where the unit cell molecular arrangement of the unknown structure is rebuilt computationally using the structure of a known molecule of assumed similar topologically. Examples of molecular replacement algorithms include AMoRe (Navaza, 1994, Acta Qystallogr. A 50:157-163), EPMR (Kissinger et al, 1999, Acta Crystallogr.
  • phase angle estimates may be obtained indirectly.
  • phase angle estimates include isomorphous replacement, single-isomorphous replacement with anomalous scattering, single wavelength anomalous dispersive and multiwavelength anomalous diffraction.
  • the structure of the protein-ligand complex specified as ITK KD/G354-Compound 4 is detennined by the method of molecular replacement.
  • One aspect of this method is the molecular arrangement of the proteins forming the crystal.
  • ITK/KD/G354 crystals are thus formed from nanotubes of protein molecules with a solvent channel size of about 9 ⁇ A diameter.
  • the molecular replacement method inherently produces an initial set of atomic coordinates for the protein referred to as the structure.
  • Refinement protocols used herein aim at improving the fit of the structure to the experimental data by minimizing the difference between the calculated amplitudes E C aic, which are generated from the structure, and the observed structure factor amplitudes F 0 bs, which are obtained from the experimental X-ray diffraction intensity data.
  • Ideal stereochemical parameters (Engh and Huber, 1991, Acta Qystallogr. A 47:392-400) are used to incorporate expected standard geometry constraints in the refinement.
  • One aspect of the present invention is the ITK/KD/G354 binding pocket that accommodates Compounds 4 and 8.
  • Figure 3 shows the conformation that Compound 4 adopts when bound to ITK/KD/G354.
  • the cyclohexyl moiety of Compound 4 is oriented nearly orthogonal to the benzimidazole scaffold.
  • Figure 4 illustrates the molecular interactions between ITK/KD/G354 and Compound 4. Among these interactions, the protein main chain of Met438 forms two hydrogen-bonds with Compound 4. Also noteworthy is the proximity between the cyclohexyl of Compound 4 and the Phe437 phenyl side chain: Some atoms of these two groups come as close as about 3.8A to each other. One possible implication of such proximity is compound selectivity.
  • a set of structural coordinates for an enzyme, an enzyme-complex, or a portion thereof is a relative set of points that define a shape in three dimensions.
  • Still another aspect of the present invention comprises a method for using a protein crystal structure of the present invention in a drag screening assay.
  • the method comprises identifying a compound as a potential inhibitor by performing rational drug design with a three-dimensional structure determined for the crystal, preferably in conjunction with computer modeling.
  • Such computer modeling is preferably initiated with a program that incorporates a Docking algorithm (Dunbrack et al, 1997, Folding & Design 2:R27-42).
  • the compound binding modes are then scored to provide a theoretical guide to the binding affinity of each compound for the particular binding site on the ITK kinase domain.
  • compound is selected as a potential inhibitor based on the scores assigned to its various binding modes to the ITK kinase domain.
  • a supplemental crystal is grown which comprises a protein-ligand complex formed between an ITK kinase domain and an initial inhibitor.
  • the crystal effectively diffracts X-rays such that the atomic coordinates of the protein- inhibitor complex can be determined to a resolution of better than 5.0 Angstroms, more preferably better than 3.0 Angstroms.
  • the three-dimensional structure of the supplemental crystal is determined by molecular replacement analysis, multiwavelength anomalous dispersion, multiple isomorphous replacements, or a combination thereof.
  • a new inhibitor with potentially greater binding affinity is then identified by structure-based design techniques using the three-dimensional structure determined for the supplemental crystal, preferably in conjunction with computer modeling.
  • the potentially improved inhibitor is then tested in a protein kinase assay such as the Tec Family Kinase Assay described herein above. All literature and patent references cited in this application are incorporated herein by reference in their entirety.
  • Example 1 ITK7KD/G354 expressed protein
  • a significant obstacle in the process of obtaining the 3-dimensional structure of a protein by X-ray crystallography is the identification of a protein fragment that is amenable to the formation of protein crystals of suitable quality. Since kinases often have multiple domains, one strategy that increases the likelihood of generating protein crystals of the kinase domain (catalytic) fragment has been to delete the other domains. Furthermore, by making a kinase domain fragment analogous to that of a related kinase for which a crystal structure has been determined, one may further increase the probability of generating suitable protein crystals. Using these concepts, the human ITK/KD/Q343 construct was generated.
  • the human ITK/KD/Q343 construct was subjected to limited proteolysis with trypsin to identify any fragments of the construct that are easily accessible to the protease and are thus likely to be less compactly folded.
  • the human ITK/KD/G354 and ITK/KD/S361 constructs were designed. To prioritize the three human ITK kinase domain protein fragments for crystallization trials, each was assayed for catalytic activity and for structural foldedness by circular dichroism-monitored thermal denaturation.
  • ITK/KD/Q343 and ITK/KD/G354 showed significant catalytic activity, whereas ITK/KD/S361 did not possess activity above background levels (Table 3).
  • ITK/KD/G354 had a higher T m than ITK KD/Q343, suggesting that ITK/KD/G354 is a more stably folded protein.
  • ITK KD/S361 had the highest T m , but the lack of catalytic activity suggests that this protein may not have a functionally competent catalytic site in the kinase domain. Consequently, the ITK/KD/G354 construct was prioritized for structural studies since it was catalytically active and predicted to be tightly folded.
  • a murine construct (ITK/KD/G353) analogous to the human ITK/KD/G354 construct was generated.
  • This murine ITK kinase domain construct has 3 conservative and 7 non-conservative amino acid substitutions when compared with the human ITK/KD/G354 construct which may alter the conformation or surface properties of the protein thus providing alternative opportunities for crystal formation.
  • Example 2 Preparation of ITK/KD/G354-Compound 4 complex Previously stored at -80°C, human ITK7KD/G354 protein at a concentration between 16 and 30 mg/mL is thawed on ice for 30 min before use.
  • Compound 4 thiophene-2-carboxylic acid [l-(2-carbamoyl-ethyl)-5-(cyclohexanecarbonyl-methyl-amino)-lH-benzoimidazol-2-yl]- amide, is dissolved with dimethyl sulfoxide (DMSO) to a concentration of 50 to 100 mg/mL at room temperature.
  • DMSO dimethyl sulfoxide
  • Protein solution is mixed with a 3 to 5 molar ratio of Compound 4 and incubated on ice for 60 to 90 min.
  • the complex is then diluted to a protein concentration of about 16 mg/mL using an ice-cold solution of 10 to 20 mM 4-(2-hydroxyethyl)-l-piperazine- ethanesulfonic acid ( ⁇ EPES) p ⁇ 7.5, 100 mM NaCI and 1 mM Tri(2-carboxyethyl)phosphine hydrochloride (TCEP).
  • ⁇ EPES 4-(2-hydroxyethyl)-l-piperazine- ethanesulfonic acid
  • TCEP Tri(2-carboxyethyl)phosphine hydrochloride
  • Example 3 ITK/KD/G354 protein crystallization Protein crystals are obtained by the vapor diffusion method using hanging drops (McPherson, 1999, Crystallization of Biological Macromolecules, Cold Spring Harbor Laboratory Press, New York) at 4°C. A drop containing the protein is let equilibrate against a reservoir solution in a sealed container. In the present example, a drop is prepared by mixing 2 ⁇ L of the ITK/KD/G354-Compound 4 complex with l ⁇ L of reservoir solution. The reservoir solution contains 5 to 15% PEG 1500, 100 mM sodium citrate pH 5 to 6 and 1 mM TCEP. Crystals typically appear between 3 to 5 weeks after setup and continue to grow to a typical size of 200 to 250 ⁇ m within 3 to 5 months.
  • Crystals are soaked with compound 8, N- ⁇ 5-(cyclohexanecarbonyl-methyl-amino)-l-[3- (4-methyl-piperazin-l-yl)-propyl]-lH-benzoimidazol-2-yl ⁇ -4-iodo-benzamide, in the following way. Crystals are transfened to a stabilizing solution containing 35% PEG 1500, lOOmM sodium citrate p ⁇ 5.30, 1 mM TCEP and 5mM Compound 8. Following an incubation period of 24-36 hrs, crystals are briefly transfened to that same solution containing an added 20% glycerol. The recovered crystals are then frozen in liquid nitrogen and kept frozen until use.
  • Example 4 ITK/KD/G354-Com ⁇ ound 4 X-ray diffraction data measurement X-ray diffraction data were measured on ITK/KD/G354-Compound 4 crystals maintained at cryogenic temperature, typically at a value of about -160°C. X-ray diffraction data were measured with X-rays of wavelength 1.0061A at the PX6S beamline of the Swiss Light Source synchrotron using a MAR CCD 165 detector. Data were reduced to integrated intensities using the software D*TREK (Rigaku MSC) and to amplitudes using TRUNCATE (CCP4, 1994, Acta Crystallogr. D 50:760-763).
  • Example 5 Structure determination of the ITK KD/G354-Compound 4 complex
  • the crystal structure of the ITK/KD/G354-Compound 4 complex is determined by molecular replacement method.
  • the structure of a homologous protein, Bruton's Tyrosine Kinase (BTK) catalytic domain (Mao et al., 2001, Journal of Biological Chemistry 276:41435- 41443) is used as a template to solve the ITK KD/G354-Compound 4 crystal structure.
  • BTK atomic coordinates used are publicly available under entry 1K2P at the Protein Databank (Bernstein et al, 1977, Journal of Molecular Biology 112:535-542).
  • An ITK/KD/G354 homology model is prepared with BTK residues A397 to A654 where equivalent ITK KD/G354 residues are modeled in with arbitrary conformations.
  • An initial ITK KD/G354 protein structure is determined by molecular replacement (Rossmann, 1972, The Molecular Replacement Method, Gordon and Breach, New York) using the program AMORE (Navaza, 1994, Acta Qystallogr. A 50:157-163) as implemented in the CCP4 software suite (CCP4, 1994, Acta Qystallogr. D 50:760-763).
  • the ITK/KD/G354 crystal molecular packing contains six protein molecules per asymmetric unit plus an estimated solvent content of 72%.
  • the first set of residues comprises those residues which are located in the ATP binding site of ITK (i.e., V377, A389, K391, V419, 1433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489); those residues which form the surface-exposed hydrophobic pocket (i.e., Q367, 1369, L379, K387) into which the cyclohexyl moiety of Compound 4 binds; and those residues which are located in the G-loop (i.e., G370, S371), near the DFG-motif (i.e., S499, D500, F501), and near the kinase specificity pocket (i.e., A406, M410).
  • ITK i.e., V377, A389, K391, V419, 1433, F435, E436, F437, M438, E439, H440, G
  • the second set of residues comprises those residues which are located in the ATP binding site of ITK; and those residues which are located in the G-loop, near the DFG- motif, and near the kinase specificity pocket, as previously defined for the RES-SETl residue set.
  • the third set of residues comprises those residues which are located in the ATP binding site of ITK, as previously defined for the RES-SETl residue set.
  • the fourth set of residues (RES-SET4) comprises those residues which are located in the ATP binding site of ITK and those residues which form the surface-exposed hydrophobic pocket, as previously defined for the RES-SETl residue set.
  • the residue numbering in Table 5 is based on the position of that residue in full-length human ITK kinase.
  • An alignment of the human ITK kinase domain with other l ⁇ iown human kinase domain sequences was performed. The parts of this alignment that pertain to the aforedescribed 4 residue sets are presented in Table 10. Based on these partial sequence alignments, the sequence identities over these four residue sets were calculated between human ITK and each of the other presented human kinases.
  • Table 6 lists, for each residue set, the kinase with the highest identity to human ITK and the associated percent identity, the kinase with the highest identity for which a structure is available and the associated percent identity, and the percent identities to human BTK, TXK, EGFR, and LCK kinases. Table 6: Percent sequence identities* between human ITK and other human Kinases
  • the backbone RMSDs have been calculated for ITK vs. BTK, ITK vs. EGFR, and ITK vs. LCK. Also the backbone RMSDs were calculated between the A and the B chain of the BTK structure to probe for the variability within a protein structure.
  • the structures were taken from the Protein Databank entries 1K2P (BTK), 1M17 (EGFR), and IQPJ (LCK). These crystal structures have respective resolutions of 2.1 A, 2.2A, and 2.6A.
  • the RMSDs are calculated by separately performing an alignment of the backbone atoms for the residues in each of the four residue sets and then measuring the RMSDs. This was done using the software program INSIGHT (Accelrys). Table 7: Backbone RMSDs for the four residue sets
  • ITK vs BTK ITK vs EGFR ITK vs LCK BTK A vs BTK B RES-SETl 1.80 1.09 0.79 1.17 RES-SET2 1.75 1.13 0.74 1.14 RES-SET3 1.08 0.61 0.60 0.74 RES-SET4 0.57 0.50 0.47 0.32
  • the alignment for the RMSD measurements differed from that used in the sequence identity analysis in that K387 of ITK was aligned with D426 of BTK, or with P717 of EGFR. All other residues were aligned h the same way.
  • the polypeptide binding pocket consisting of residues Q367, 1369, L379, K387, and F437 of SEQ ID NO. 1 has a backbone-atom R.m.s.d. of 0.42 Angstroms to the conesponding residues in LCK, 0.55 Angstroms to the conesponding residues in EGFR, and 1.42 Angstroms to the conesponding residues in BTK.
  • the RMSD is measured as described above.
  • Example 7 Murine ITK/KD/G353-ITK Inhibitor Complex Formation, Crystallization and X-ray Diffraction
  • a solution of murine ITK KD/G353 protein (SEQ ID NO. 16) at a concentration of 10 to 31.5 mg/mL, previously frozen at -80°C is thawed on ice for 30 minutes before use.
  • a suitable compound which inhibits ITK is dissolved with dimethyl sulfoxide (DMSO) to a concentration ot i ⁇ mg/mL at room temperature.
  • DMSO dimethyl sulfoxide
  • the ITK inhibitor is mixed with the protein solution at 5 molar ratio of inhibitor to protein. The mixture is incubated on ice for 60 to 90 minutes.
  • Protein crystals are obtained by vapor diffusion methos using hanging drops at room temperature.
  • a drop containing ITK/KD/G353-ITK inhibitor complex is let to equilibrate against a reservoir solution in a sealed container, hi the present example, a hanging drop is prepared by mixing l ⁇ L of the ITK/KD/G353- ITK inhibitor with an equal volume of reservoir solution.
  • the reservoir solution contains 10 to 18% polyethyleneglycol 5000 monomethylether, 100 mM sodium citrate pH 5 to 6 and 1 mM TCEP.
  • An ITK/KD/G353- ITK inhibitor crystal is transfened to a stabilizing solution containing
  • glycerol 25% glycerol and 20 mM ITK inhibitor.
  • the crystal is flash-frozen in a cold stream at cryogenic temperature of about -160°C.
  • X-ray diffraction data are measured with an RU-H3R rotating anode-based generator (Rigaku/MSC) operating at 50 kV/60 mA equipped with an R-
  • Axis-IV++ detector (Rigaku/MSC) and confocal blue optics (Osmics). X-ray diffraction data to
  • the crystal has an estimated solvent content of about 75% and one protein assembly per asymmetric unit.
  • ATOM 110 CA GLY 375 45.241 58.962 4.847 1.00 33.48 A
  • ATOM 690 CB MET 462 52.330 85.214 6.001 1.00 33.48 A
  • ATOM 753 CA ALA 471 65.160 79.411 0.325 1.00 33, .48 A
  • ATOM 758 CA TYR 472 66.384 76.619 2.599 1.00 33 .48 A
  • ATOM 801 CA CYS 477 67.859 70.900 -3.561 1.00 33 .48 A
  • ATOM 814 CA ILE 479 61.805 70.516 -4.601 1.00 33 .48 A
  • ATOM 830 O HIS 480 57.079 72.178 -4.596 1.00 33 .48
  • a ATOM 831 N ARG 481 57.156 69.956 -4.826 1.00 33.48 A
  • ATOM 835 CD ARG 481 57.762 66.492 -6.864 1.00 33.48 A

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Abstract

Disclosed are polypeptides encoding the ITK kinase domain and nucleic acids encoding such polypeptides, crystal structures of various polypeptide-ligand complexes comprising the ITK kinase domain bound to a ligand, methods of producing the aforementioned polypeptides and nucleic acids which encode them and methods of producing crystal structures of the aforementioned polypeptides comprising the ITK kinase domain bound to a ligand.

Description

CRYSTAL STRUCTURE OF THE INTERLEUKIN-2-INDUCIBLE CELL KINASE (ITK) KINASE DOMAIN
Application Data This application claims benefit to US provisional no. 60/533,434 filed 12/30/2003. Field of Invention The field of the invention relates to kinases, particularly ITK, which are attractive targets for the treatment of human diseases.
Background of the Invention Kinases are key regulatory enzymes in eukaryotic signaling pathways. As such, kinases are attractive targets for pharmaceutical intervention in the treatment of human diseases. Non- receptor tyrosine kinases are critically involved in transmitting signals through antigen receptors on hematopoietic cells. Whereas the Src family and ZAP-70/Syk kinases function as on off switches downstream of antigen receptors, the Tec family of kinases plays a signal amplification role (August et al, 2002, Int J Biochem Cell Biol 34: 1184- 1189). Interleukin-2-inducible T cell kinase (ITK), also known as T cell-specific kinase (TSK) and expressed mainly in T cells (EMT) (Siliciano et al, 1992, Proc. Natl Acad. Sci. USA 89: 11194-11198; Gibson et al, 1993, Blood 82: 1561-1572; Heyeck and Berg, 1993, Proc. Natl Acad. Sci. USA 90:669-673), is a member of the Tec kinase family whose expression is restricted to T cells, mast cells, and NK cells. ITK has been demonstrated to be involved in signaling tlirough the T cell receptor (TCR) (reviewed in (Miller and Berg, 2002, Curr. Opin. Immunol. 14:331-340)) and, on mast cells, the high affinity IgE receptor (FcεRI) (Kawakami et al, 1995, J. Immunol. 155:3556-3562). Upon receptor cross-linking, upstream activation of Src family and ZAP-70/Syk kinases is required for activation of ITK. Src kinases phosphorylate , ITK on the activation loop which is required before ITK can autophosphorylate leading to further activation (Heyeck et al, 1997, JBiol Chem 272:25401-25408). Additionally required for full activity, ITK must be recruited from the cytosol to the membrane through interactions with phosphatidyl inositol 3,4,5-trisphosphate produced upon PI3K activation and the SLP- 76/LAT complex which is phosphorylated by ZAP-70/Syk kinases. These interactions are mediated by the ITK pleckstrin homology and the SH2 domains, respectively. Although numerous binding partners for ITK have been identified, the best understood role for ITK is in the phosphorylation of PLC-γ which is required for the production of inositol 1,4,5-trisphosphate and diacylglycerol which are necessary for calcium mobilization and PKC activation, respectively, thus activating numerous downstream pathways (reviewed in (August et al, 2002, Int J Biochem Cell Biol 34: 1184- 1189)). In vivo studies on ITK have focused on its role in T cell development and function, hi the absence of ITK, mice have ~50% fewer CD4 T cells due to a defect in positive selection. The surviving CD4+ T cells are defective in proliferation and cytokine production upon TCR stimulation in vitro or ex vivo. In vivo, ITK deficient mice do not mount a Th2 response to the pathogens Leishmania major, Nippostrongylus brasiliensis, or Schistosoma mansoni in contrast to wild-type mice (Liao and Liftman, 1995, Immunity 3:757-769; Fowell et al., 1999, Immunity 11:399-409; Schaeffer et al., 2001, Nature Immunol. 2: 1183-1188). Consistent with a defective Th2 response, ITK deficient mice exhibit reduced lung inflammation, eosinophil infiltration, and mucus secretion in an allergic asthma model (Mueller and August, 2003, J. Immunol. 170:5056- 5063). Additional studies are still required to address the role of ITK in Thl and CD8+ T cells in addition to mast cells in animal models of disease. The catalytic domain of kinases contains conserved motifs that are required for protein structure and function. However, the precise tertiary structure of kinases, especially when bound by ligand, often cannot be predicted or modeled accurately. To date, three-dimensional structural data on the ITK kinase domain has not been available, thus hindering rational, structure-based design of antagonists to ITK kinase activity. Summary of the Invention It is therefore an object of the invention to provide both polypeptides encoding the ITK kinase domain and nucleic acids encoding such polypeptides. It is another object of the invention to provide crystal structures of various polypeptide- ligand complexes comprising the ITK kinase domain bound to a ligand which provides the proper crystal structure as defined herein below. It is yet a further object of the invention to provide methods of producing the aforementioned polypeptides and nucleic acids which encode them. It is yet another object of the invention to provide methods of producing crystal structures of the aforementioned polypeptides comprising the ITK kinase domain bound to a ligand.
Brief Description of the Drawings
Figure 1: Ribbon diagram representation of ITK/KD/G354: Compound 4 co-crystal structure. Secondary-structure elements are shown as arrows for beta-strands and as helices for alpha- helices. Compound 4 is shown with spheres for each non-hydrogen atom. Figure 2: Carbon-alpha trace of ITK/KD/G354 shown in stereo projection. Figure 3: Section of the electron density representation of Compound 4, shown in stereo projection. This electron density map is drawn with coefficients 2E0bs-Ecaic and contoured at the level of the standard deviation of the entire map.
Figure 4: Schematic representation of Compound 4 interactions with ITK/KD/G354. Hydrogen bonds are depicted with thick dash lines. Only Van der Waals interactions, i.e. only inter- molecular distances less than 3.8A between non-hydrogen atoms, are shown with dotted lines. Figure 5: Sequence alignment of the kinase domain from human, rat, mouse and zebra fish ITK orthologs.
Description of the Sequences
SEQ ID NO. 1 is the amino acid sequence of the human ITK kinase domain fragment
ITK KD/G354 used for X-ray crystallographic studies, which comprises ITK residues 354-620 of the full-length, wild-type ITK kinase (SEQ ID NO. 2). Thrombin cleavage of GST-
ITK/KD/G354 (SEQ ID NO. 7) produces this kinase domain fragment which contains the vector-encoded sequence glycine-serine-methionine immediately N-terminal to ITK residue glycine 354.
SEQ ID NO. 2 is the amino acid sequence of the full-length, wild-type human ITK kinase
(GenBank Accession No. AAQ02517).
SEQ ID NO. 3 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 343-620 of the full-length, wild-type ITK kinase, with an additional methionine encoded within the plasmid pITK/KD/Q343/GemT inserted immediately N-terminal to ITK residue glutamine 343.
SEQ ID NO.4 is the DNA sequence of the plasmid pGST/1393 which is a baculoviral transplacement vector derived from pVL1393 (InVitrogen Life Technologies) which is modified to contain a gene encoding glutathione-S-transferase (GST) positioned 3' to the polyhedrin promoter. DNA fragments inserted 3' to the GST gene in the multiple cloning site produce fusion proteins C-terminal to GST upon expression.
SEQ ID NO. 5 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 343-620 (GST-ITK/KD/Q343) of the full-length, wild-type ITK kinase. This GST fusion protein is encoded by the plasmid pGST-
ITK/KD/Q343/1393. SEQ ID NO. 6 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 354-620 of the full-length, wild-type ITK kinase, with an additional methionine encoded within the plasmid pITK/KD/G354/GemT inserted immediately N-terminal to ITK residue glycine 354.
SEQ ID NO. 7 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 354-620 (GST-ITK/KD/G354) of the full-length, wild-type ITK kinase. This GST fusion protein is encoded by the plasmid pGST-
ITK/KD/G354/1393.
SEQ ID NO. 8 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 354-620 (GST-ITK KD/G354) of the full-length ITK kinase in which phenylalanine residue 437 (numbered based on its position in the full-length, wild-type human ITK kinase) is substituted with a tyrosine residue (designated GST-
ITK KD/G354/F437Y). This GST fusion protein is encoded by the plasmid pGST-
ITK/KD/G354/F437Y/1393.
SEQ ID NO. 9 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 343-620 of the full-length, wild-type ITK kinase (SEQ ID NO.2).
Thrombin cleavage of GST-ITK/KD/Q343 (SEQ ID NO. 5) produces this kinase domain fragment which contains the vector-encoded sequence glycine-serine-methionine immediately
N-terminal to ITK residue glutamine 343.
SEQ ID NO. 10 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 361-620 of the full-length, wild-type ITK kinase, with an additional methionme encoded within the plasmid pITK/KD/S361/GemT inserted immediately N-terminal to ITK residue serine 361.
SEQ ID NO. 11 is the amino acid sequence of the GST fusion protein to the human ITK kinase domain fragment comprising ITK residues 361-620 (GST-ITK KD/S361) of the full-length, wild-type ITK kinase. This GST fusion protein is encoded by the plasmid pGST-
ITK KD/S361/1393.
SEQ ID NO. 12 is the amino acid sequence of the human ITK kinase domain fragment comprising ITK residues 361-620 of the full-length, wild-type ITK kinase (SEQ ID NO. 2).
Thrombin cleavage of GST-ITK/KD/S361 (SEQ ID NO. 11) produces this kinase domain fragment which contains the vector-encoded sequence glycine-serine-methionine immediately
N-terminal to ITK residue serine 361.
SEQ ID NO. 13 is the amino acid sequence of the full-length, wild-type murine ITK kinase
(GenBank Accession No. CAI24846).
SEQ ID NO. 14 is the amino acid sequence of the murine ITK kinase domain fragment comprising ITK residues 353-619 of the full-length, wild-type murine ITK kinase, with an additional methionine encoded within the plasmid pmITK/KD/G353/TOPO inserted immediately N-terminal to ITK residue glycine 353.
SEQ ID NO. 15 is the amino acid sequence of the GST fusion protein to the murine ITK kinase domain fragment comprising ITK residues 353-619 (GST-mITK/KD/G353) of the full-length, wild-type ITK kinase. This GST fusion protein is encoded by the plasmid pGST- mITK/KD/G353/1393.
SEQ ID NO. 16 is the amino acid sequence of the murine ITK kinase domain fragment comprising ITK residues 353-619 of the full-length, wild-type murine ITK kinase (SEQ ID NO.
13). Thrombin cleavage of GST-mITK/KD/G353 (SEQ ID NO. 15) produces this kinase domain fragment which contains the vector-encoded sequence glycine-serine-methionine immediately N-terminal to ITK residue glycine 353. Detailed Description of the Invention This invention provides certain crystallized, protein kinase-ligand complexes, in particular ITK kinase domain-ligand complexes, and their structural coordinates. The structural coordinates are based on the structure of a ligand-bound ITK kinase domain complex that has now been solved and refined to a resolution 3.0 A and which reveals new structural information. The key structural features of the ITK kinase domain, particularly the shape of the ATP-binding site, are useful to methods for designing inhibitors of the ITK kinase activity and for solving the structures of other proteins with similar features. In one embodiment, the invention provides a crystal of a polypeptide- ligand complex that comprises the ITK kinase domain and a ligand. Preferred ITK kinase domains include ITK/KD/S361 (SEQ ID NO. 12), ITK/KD/Q343 (SEQ ID NO. 9) and ITK/KD/G354 SEQ ID NO. 1, with the most preferred being human ITK KD/G354. In another embodiment, the invention provides a crystal of a polypeptide-ligand complex that comprises the ITK kinase domain ITK KD/G353 SEQ ID NO. 16. It shall be understood that all ITK kinase domains described herein are mammalian, preferably human and murine. In describing protein structure and function, reference is made to amino acids comprising the protein. It shall be understood that the terms protein and polypeptide can be used interchangeably and are both defined as a polymer of two or more amino acids covalently linked by peptide bonds. The amino acids may also be referred to by their conventional abbreviations, as shown in the Table 1 below.
Table 1
A = Ala = Alanine T = Thr = Threonine V = Val = Valine C = Cys = Cysteine L = Leu = Leucine Y = Tyr = Tyrosine I = He = Isoleucine N = Asn = Asparagine P = Pro = Proline Q = Gin = Glutamine F = Phe = Phenylalanine D = Asp = Aspartic Acid W = Trp = Tryptophan E = Glu = Glutamic Acid M = Met = Methionine K = Lys = Lysine G = Gly = Glycine R = Arg = Arginine S = Ser = Serine H = His = Histidine
A crystal, as defined herein below, according to the invention may take a variety of forms, all of which are included in the present invention. The term 'ligand' shall be understood to include any molecule that forms a complex with an ITK kinase domain, as defined herein below, according to the invention and can be used to form a crystal of the present invention. Preferred ligands include substituted benzimidazole compounds shown in Table 2 below. Analogs, positional and stereoisomer isomers thereof which provide a crystal structure are within the scope of the invention and will be apparent to those of ordinary skill in the art.
Isolating the ITK Kinase Domain
DNA cloning and baculovirus generation In one aspect of the invention, there is provided novel nucleic acids encoding the ITK kinase domain as described herein below. In yet another aspect of the invention, there is provided vectors comprising said nucleic acids. The nucleic acids and vectors are prepared as follows: A DNA fragment encoding amino acids 343-620 of the full-length, wild-type human ITK kinase (SEQ ID NO. 2) was PCR-amplified from an unstimulated human peripheral blood leukocyte cDNA library (Clontech) using oligonucleotide pairs 5'- GGGATCCATGCAGAAAGCCCCAGTTACAGCAGG-3' and 5'- GCGGCCGCCTAAAGTCCTGATTCTGCAATTTCAGCC-3' and ligated into pGem-T (Promega) to make pITK/KD/Q343/GemT wherein a methionine residue is inserted immediately N-terminal to Q343 of ITK to generate the predicted ITK kinase domain protein in SEQ ID NO. 3. The BamHl to Notl ITK kinase domain encoding fragment from pITK/KD/Q343/GemT was ligated into pGST/1393 (SEQ ID NO. 4) at the same sites to generate pGST- ITK/KD/Q343/1393 which encodes a GST-ITK/KD/Q343 fusion protein (SEQ ID NO. 5). A DNA fragment encoding amino acids 354-620 of the full-length, wild-type human ITK kinase (SEQ ID NO. 2) was PCR-amplified from pGST-ITK KD/Q343/1393 using oligonucleotide pairs 5'-GGGATCCATGGGGAAATGGGTGATCGACC-3' and 5'- GCGGCCGCCTAAAGTCCTGATTCTGCAATTTCAGCC-3' and ligated into pGem-T to make pITK/KD/G354/GemT wherein a methionine residue is inserted immediately N-terminal to G354 of ITK to generate the predicted ITK kinase domain protein in SEQ ID NO. 6. A DNA fragment encoding amino acids 361-620 of the full-length, wild-type human ITK kinase was PCR-amplified from pGST-ITK/KD/Q343/1393 using oligonucleotide pairs 5'- GGGATCCATGTCAGAGCTCACTTTTGTGC -3' and 5'-
GCGGCCGCCTAAAGTCCTGATTCTGCAATTTCAGCC-3' and ligated into pGem-T to make pITK/KD/S361/GemT wherein a methionine residue is inserted immediately N-terminal to S361 of ITK to generate the predicted ITK kinase domain protein in SEQ ID NO. 10. The BamΗI to Notl ITK kinase domain encoding fragments from pITK/KD/G354/GemT and pITK/KD/S361/GemT were ligated into pGST/1393 at the same sites to generate pGST- ITK/KD/G354/1393 and pGST-ITK/KD/S361/1393 which encode the fusion proteins GST- 11K/KD/G354 (SEQ ID NO. 7) and GST-ITK/KD/S361 (SEQ ID NO. 11), respectively. pGST- ITK/KD/G354/F437Y/1393 which, in the GST-ITK/KD/G354 construct, encodes a tyrosine in place of a phenylalanine at residue 437 of the full-length human ITK kinase sequence was generated using the complementary oligonucleotides 5'- CCTGGTGTTTGAGTACATGGAGCACGGCT-3' and 5'-
AGCCGTGCTCCATGTACTCAAACACCAGG-3' and using pGST-ITK/KD/G354/1393 as a template with the QuikChange site-directed mutagenesis kit (Stratagene) to generate pGST- ITK/G354/F437Y/1393 which encodes GST-ITK/G354/F437Y (SEQ ID NO. 8). A DNA fragment encoding amino acids 342-619 from the murine ITK kinase (SEQ ID NO. 13) was PCR-amplified from a mouse spleen cDNA library (Clontech) using oligonucleotide pairs 5'- CAAAAAGCCCCTGTCAC-3' and 5 '-GGCGGCCGCCTAAAGCCCAGCTTCTGCG-3' and ligated into TrcHis2-TOPO (Invitrogen) to make pmιTK/KD/Q342/TOPO. A DNA fragment encoding amino acids 353-619 from the murine ITK kinase (SEQ ID NO. 13) was PCR- amplified from pmITK/KD/Q342/TOPO using oligonucleotide pairs 5'- GGGATCCATGGGGAAGTGGGTGATCCAAC-3' and 5'-
GGCGGCCGCCTAAAGCCCAGCTTCTGCG-3' and ligated into pCRII-TOPO (hivitrogen) to make pmITK/KD/G353/TOPO wherein a methionine residue is inserted immediately N-terminal to G353 of ITK to generate the predicted protein in SEQ ID NO. 14. The BamUl to Notl ITK kinase domain encoding fragment from pmITK/KD/G353/TOPO was ligated into pGST/1393 (SEQ ID NO. 4) at the same sites to generate pGST-mITK/KD/G353/1393 which encodes a GST-mITK/KD/G353 fusion protein (SEQ ID NO. 15). Recombinant baculovirus stocks were generated by standard methods (O'Reilly et al, 1992, Baculovirus Expression Vectors: A Laboratory Manual W.H. Freeman & Co.) using the pGST-ITK/KD/Q343/1393, pGST- ITK/KD/G354/1393, pGST-ITK/G354/F437Y/1393, pGST-ITK/KD/S361/1393, pGST- mITK/KD/G353/1393 vectors. In yet another aspect of the invention, there is provided a process of producing the ITK kinase domain polypeptides as described herein. Said polypeptides can be produced as follows: Protein expression and purification Spodoptera frugiperda (S£21) cells were maintained and infected as described previously (Dracheva et al, 1995, J Biol Chem 270:14148-14153) using medium supplemented with 5% heat-inactivated fetal bovine serum (Hyclone) and 50 μg/ l gentamicin sulfate (Life Technologies, Inc.). All purification procedures were performed at 4°C. Cytosolic extracts of baculovirus-infected Sf21 cells were prepared as described (Pullen et al, 1998, Biochemistry 37:11836-11845). Extracts were applied to a glutathione sepharose 4B column (Amersham) equilibrated in Buffer A (20 mM HEPES, pH 7.5, 150 mM NaCI, 1 mM TCEP, 10% v/v glycerol, 0.1 mM EDTA, 0.1 mM EGTA, and 1 mM PMSF). The column was washed with Buffer A containing 400 mM NaCI. GST-ITK/KD/G354 and GST-ITK/KD/G354/F437Y were eluted in Buffer A containing 150 mM NaCI and 10 mM glutathione. Alternatively, protein was eluted by flowing bovine thrombin (USB) at 20 units/mL onto the column in 50 mM Tris, pH 8.0, 2.5 mM CaCl2, 10 % v/v glycerol, and 150 mM NaCI. The amino acid sequences of the resulting thrombin cleaved proteins ITK/KD/Q343, ITK/KD/G354, ITK/KD/S361, and mITK/KD/G353 are shown in SEQ ID NO. 9, SEQ ID NO. 1, SEQ ID NO. 12, and SEQ ID NO. 16, respectively. Peak fractions containing the ITK kinase domain were pooled, diluted with an equal volume of Buffer B (10 mM Tris, pH 7.2, 100 mM NaCI, 5% glycerol, 0.5 mM TCEP), applied to a Macro-Prep DEAE column equilibrated in Buffer B, and proteins were eluted with a 0 to 500 mM NaCI gradient in Buffer B. Peak fractions were pooled and applied to a Sephacryl S-100 HR column preequilibrated with 10 mM HEPES, pH 7.5, 100 mM NaCI, and 1.0 mM TCEP. Peak fractions were pooled, concentrated to approximately 30 mg/ml using a Vivaspin 30 K MWCO concentrator (Sartorius), quantified, frozen in aliquots under liquid nitrogen, and stored at -80°C. Sample purity was verified by SDS-PAGE analysis and electrospray ionization mass spectrometry.
Definition of kinase domain fragment The term ITK kinase domain shall be understood to mean a polypeptide construct comprising residues 354-620 of human ITK (ITK/KD/G354) which binds a ligand as defined herein. Such bound ligands include, but are not limited to, inhibitor small molecules. This inhibition is expressed as an IC50 value that is determined either by the Tec Family Kinase Assay described below or by other methods known in the art to measure μM to nM IC50 values for small-molecule inhibitors. Examples of small molecule ITK inhibitors include, but are not limited to, those compounds shown in Table 2 and Compound 8. ITK/KD/Q343 was subjected to limited digestion with trypsin to identify fragments of the ITK kinase domain that are resistant to proteolysis due to being folded in a more stable and compact conformation. Protein fragments were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis. Characterization of the fragments indicated that residues N-terminal to R352 are accessible to trypsin. Consequently, an ITK kinase domain construct including residues 354-620 of human ITK (ITK KD/G354) was designed to increase the stability of the protein. Additionally, an ITK kinase domain construct including residues 361-620 of human ITK (ITK/KD/S361) was designed to remove all but two residues N-terminal to subdomain I of the kinase, based on the Hanks classification of protein kinases (Hanks and Hunter, 1995, FASEB J. 9:576-596), in case these are disordered in the context of the shorter ITK/KD/G354 construct. These constructs are described in the DNA cloning and baculovirus generation section.
Selection of murine ITK kinase domain fragment The murine ITK kinase domain fragment including residues 342-619 has 3 conservative and 7 non-conservative amino acid substitutions when compared with human ITK kinase domain residues 343-620. To improve the likelihood of obtaining ITK kinase domain protein crystals of suitable size and quality, an ITK kinase domain construct including residues 353-619 of murine ITK (mITK/KD/G353) homologous to the stable human fragment (ITK/KD/G354) was designed as described in the DNA cloning and baculovirus generation section.
Tec Family Kinase Assay ITK is purified as a GST-fusion protein to test for catalytic activity. The kinase activity is measured using DELFIA (Dissociation Enhanced Lanthanide Fluoroimmunoassay) which utilizes europium chelate-labeled anti-phosphotyrosine antibodies to detect phosphate transfer to a random polymer, poly Glu4: Tyri (PGTYR). The screen utilizes the Zymark Allegro UHTS system to dispense reagents, buffers and samples for assay, and also to wash plates. The kinase assay is performed in kinase assay buffer (50 mM HEPES, pH 7.0, 25 mM MgCl2, 5 mM
MnCl2, 50 mM KC1, 100 μMNa3VO4, 0.2% BSA, 0.01% CHAPS, 200 μM TCEP). Test samples initially dissolved in DMSO at 1 mg/mL, are pre-diluted for dose response (9 doses with starting final concentration of 3 μg/mL, 1 to 3 serial dilutions) with the assay buffer in 384- well polypropylene microtiter plates. A 10 μL volume/well of a mixture of substrates containing
15 μM ATP and 9 ng/μL PGTYR-biotin (CIS Bio international) in kinase buffer is added to neutravidin coated 384-well white plate (PIERCE), followed by 20 μL/well test sample solution and 20 μL/well of diluted enzyme (1-7 nM final concentration). Background wells are incubated with buffer, rather than 20 μL enzyme. The assay plates are incubated for 30 min at room temperature. Following incubation, the assay plates are washed three times with 100 μL wash buffer (50 mM Tris-HCL, pH 7.4, 150 mM NaCI, 0.05% Tween 20, 0.2% BSA). A 50 μL aliquot of europium-labeled anti-phosphotyrosine (Eu3+-PT66, Wallac CR04-100) diluted in 50 mM Tris-HCI, pH 7.8, 150 mMNaCl, 10 μM DTPA, 0.05% Tween 40, 0.2% BSA, 0.05% BGG (1 nM final concentration) is added to each well and incubated for 30 min at room temperature. Upon completion of the incubation, the plate is washed four times with 100 μL of wash buffer and 50 μL of DELFIA Enhancement Solution (Wallac) is added to each well. After 15 min, time-resolved fluorescence is measured on the LJL's Analyst (excitation at 360 nm, emission at 620 nm, EU 400 Dichroic Mirror) after a delay time of 250 μs. An IC50 can be obtained by fitting the rates vs. compound/ligand concentration data into a simple competitive inhibitor model. Under these assay conditions, a 3-fold difference in compound potency (IC50) is considered within the variation of the assay. Preferred ligands will have an IC50 < 1000 nM.
6. Thermal Denaturation of ITK Constructs
Thermal denaturation experiments were performed on a Jasco J-720 spectropolarimeter equipped with a Peltier thermostatic cell holder. For each measurement, a 1 cm quartz cuvette was loaded with 5 μM ITK kinase domain construct in a pH 7.0 buffer containing 10 mM sodium phosphate, 100 mM NaCI and 1 mM TCEP. Absorbance data at 230 nm was collected as the temperature was scanned from 2 to 100 °C at a ramp rate of 0.2 °C/min. The melting temperature (Tm) for each sample was calculated as the maximum deflection point of the first derivative of the melting transition using Origin (version 7.0).
Rational mutant design ITK/KD/G354 F437Y The ITK residues Q367, 1369, L379, K387, and F437, numbered based on the position in the full-length, wild-type human ITK kinase, define a shallow, surface-exposed hydrophobic pocket on ITK KD/G354 that has not been described in previous kinase crystal structures. The observed interaction of Compound 4 with this hydrophobic pocket region suggests that it could contribute to favorable compound interaction. Moveover, Phe437 extends its side chain toward Compound 4 such that the Phe Cζ (4-position aromatic carbon) is found in close proximity to the cyclohexyl moiety of Compound 4. These observations suggest that an additional hydroxyl on this protein Phe437 residue side chain, such as that found in a Phe437Tyr mutant, may be less favorable for the binding of compounds having a hydrophobic six-membered ring at the Compound 4 cyclohexyl position. To test this hypothesis, a human ITK mutant has been generated where Phe437 is mutated to a tyrosine residue (F437Y mutant) in the construct GST- ITK KD/G354 to generate GST-ITK/KD/G354/F437Y. Tyrosine is the most common amino acid at this position of kinases (Kostich et al, 2002, Genome Biol. 3:1-12) and would be predicted to interfere with the binding of Compound 4 based both on the introduction of a polar functionality into the hydrophobic pocket and on a steric interaction with the cyclohexyl ring of Compound 4. As indicated in Table 2, ITK with the F437Y substitution (GST- ITK KD/G354/Y437Y) is inhibited less than the wild-type ITK kinase domain (GST- ITK/KD/G354) by compounds with a six-membered hydrophobic ring functionality, such as an optionally substituted aryl, heteroaryl or cycloalkyl moiety. In contrast, compounds lacking this hydrophobic functionality have similar potency against the wild-type and F437Y substituted kinase. These results demonstrate that compounds including such a hydrophobic functionality selectively inhibit ITK which contains the shallow, hydrophobic pocket versus kinases with a tyrosine at the analogous position to ITK residue 437 in which this pocket is perturbed. These findings are consistent with: (1) the shallow hydrophobic pocket contributing to binding interactions with the compounds and thus providing a previously undescribed site for interactions with kinase inhibitors; (2) residue 437 being involved in compound specificity in a protein containing a tyrosine at this position, such as the Phe437Tyr ITK/KD/G354 mutant. Table 2
Figure imgf000018_0001
1TK KD/G354 crystallization The term 'crystal' or 'protein crystal' shall be understood to mean a product of the process of obtaining crystals of the ITK kinase domain protein-ligand complex, with said process comprising:
(a) obtaining a crystallizable composition, with said crystallizable composition comprising an ITK kinase domain protein, suitable cations and a ligand according to the invention; and
(b) subjecting the composition of step (a) to conditions which promote crystallization. Another aspect of this invention relates to a method for preparing crystals containing an ITK kinase domain protein-ligand complex. It is inferred by those skilled in the art that a variety of techniques and suitable conditions which promote crystallization may be used to grow protein or protein-ligand crystals. This includes, but is not limited to, batch, under-oil batch, dialysis, vapor diffusion by either sitting or hanging drops, and liquid bridge (Ducruix and Geige, 1992, Crystallization of Nucleic Acids and Proteins: A practical Approach, IRL Press, Oxford, England; McPherson, 1999, Crystallization of Biological Macromolecules, Cold Spring Harbor Laboratory Press, New York). In the most general case, any one of the above techniques may be used to grow ITK/KD/G354 crystals. In a preferred embodiment, the vapor diffusion method is used to grow ITK/KD/G354 crystals. In a more preferred embodiment, Compound 4 is used to grow ITK/KD/G354 protein-ligand crystals by means of the vapor diffusion method. In an even more preferred embodiment, hanging drops are used with the vapor diffusion method and with Compound 4 to grow ITK/KD/G354 protein-ligand crystals. A most preferred crystallization protocol is disclosed in the examples section. The vapor diffusion method involves the equilibration of one or more drops containing the protein formulation against a larger reservoir solution in a sealed well. These drops may be sitting or hanging. In the most general case, the reservoir solution contains a precipitant constituent that is more concentrated than it is in the drop. In a preferred embodiment, this precipitant is 5 to 15% polyethylene glycol 1500 (PEG 1500). In an even more preferred embodiment, 8 to 12% PEG 1500 is used. A most preferred crystallization protocol is disclosed in the examples section. Such a formulation is applicable with human ITK/KD/G354-ligand, but is different when used with the murine ITK/KD/G353 -compound preparation. The preferred precipitant for murine ITK/KD/G353-compound crystallization is 7 to 30% polyethylene glycol 5000 monomethylether, a more preferred precipitant being 10 to 18% polyethylene glycol 5000 monomethylether. A most preferred crystallization protocol is disclosed in the examples section. The crystallization solution pH is an important factor influencing protein crystallization. Commonly, an optimal pH is achieved by adjusting the reservoir solution pH and by using some of this solution in the protein crystallization drop. In a preferred embodiment, the reservoir solution contains lOOmM sodium citrate pH 5 to 6. In a more preferred embodiment, the buffer solution used is first adjusted to pH 5.2-5.4, then autoclaved, at which point the buffer pH changes to values of 5.55-5.75, and finally used with the other constituents to form the reservoir solution. A most preferred protocol is disclosed in the examples section. Once a crystal of the present invention is grown, it can be characterized by X-ray diffraction. More than one method may be used to generate X-rays and to characterize the diffraction pattern. For example, X-rays used may be generated from a conventional source, such as a sealed tube or rotating anode, or from a synchrotron source. Methods of characterization include, but are not limited to, diffractometer data collection, precession photography and Laue diffraction. Data may be processed using D*TREK (Rigaku MSC), MOSFLM (Leslie, 1999, Ada Crystallogr. D 55:1696-1702) or a combination of DENZO and SCALEPACK (Otwino ski and Minor, 1997, Meth. Enzymol. 276:307-326). Examples herein provide a statistical sampling of X-ray diffraction data measurement, data reduction and analyses. Crystal structure determination A structure determination using X-ray diffraction requires phase angle estimates to be combined with the diffraction data. In the case of macromolecules, such phase angle estimates may be derived from a known structure of similar topology, from ab initio using indirect methods, or a combination thereof. The former is achieved using molecular replacement methods, where the unit cell molecular arrangement of the unknown structure is rebuilt computationally using the structure of a known molecule of assumed similar topologically. Examples of molecular replacement algorithms include AMoRe (Navaza, 1994, Acta Qystallogr. A 50:157-163), EPMR (Kissinger et al, 1999, Acta Crystallogr. D 55:484-491), MERLOT (Fitzgerald, 1988, J. Appl. Qyst. 21:273-278) and X-PLOR (Briinger et al, 1987, Science 235:458-460). Alternatively, phase angle estimates may be obtained indirectly. Examples of such methods include isomorphous replacement, single-isomorphous replacement with anomalous scattering, single wavelength anomalous dispersive and multiwavelength anomalous diffraction. In a preferred embodiment, the structure of the protein-ligand complex specified as ITK KD/G354-Compound 4 is detennined by the method of molecular replacement. One aspect of this method is the molecular arrangement of the proteins forming the crystal. Most commonly found in known crystal structures are one, occasionally two, and rarely more than two protein molecules per asymmetric unit. Exemplified herein is a assembly of six individual ITK/KD/G354 protein molecules that define the asymmetric unit which also includes an estimated 72% solvent. These six molecules are replicated six times according to the hexagonal unit cell space group symmetry P64 to form the unit cell and subsequently replicated along axes a, b and c to fonn the crystal. ITK/KD/G354 crystals are thus formed from nanotubes of protein molecules with a solvent channel size of about 9θA diameter. The molecular replacement method inherently produces an initial set of atomic coordinates for the protein referred to as the structure. This structure is subjected to rounds of refinement interspersed with model rebuilding using O (Jones et al, 1991, Acta Crystallogr. A 47: 110-119) or Quanta (Accelrys). Refinement is performed using CNX (Accelrys; Brunger, 1988, J. Mol. Biol. 203:803-816), REFMAC (Murshudov et al, 1997, Acta Qystallogr. D 53:240-255) or other protein refinement software. Refinement protocols used herein aim at improving the fit of the structure to the experimental data by minimizing the difference between the calculated amplitudes ECaic, which are generated from the structure, and the observed structure factor amplitudes F0bs, which are obtained from the experimental X-ray diffraction intensity data. Ideal stereochemical parameters (Engh and Huber, 1991, Acta Qystallogr. A 47:392-400) are used to incorporate expected standard geometry constraints in the refinement. One aspect of the present invention is the ITK/KD/G354 binding pocket that accommodates Compounds 4 and 8. Figure 3 shows the conformation that Compound 4 adopts when bound to ITK/KD/G354. The cyclohexyl moiety of Compound 4 is oriented nearly orthogonal to the benzimidazole scaffold. Figure 4 illustrates the molecular interactions between ITK/KD/G354 and Compound 4. Among these interactions, the protein main chain of Met438 forms two hydrogen-bonds with Compound 4. Also noteworthy is the proximity between the cyclohexyl of Compound 4 and the Phe437 phenyl side chain: Some atoms of these two groups come as close as about 3.8A to each other. One possible implication of such proximity is compound selectivity. Those of skill in the art understand that a set of structural coordinates for an enzyme, an enzyme-complex, or a portion thereof, is a relative set of points that define a shape in three dimensions. Thus, it is possible that an entirely different set of coordinates could define a similar or identical shape. Moreover, slight variations in the individual coordinates will have little effect on the overall shape. In terms of binding pockets, these variations would not be expected to significantly alter the nature of ligands that could associate with those pockets. Modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal could also account for variations in structural coordinates. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three- dimensional shape is considered to be the same. Thus, for example, a ligand that binds to the Compound 4-binding region of ITK kinase domain would also be expected to bind to another binding pocket whose structural coordinates defined a shape that fell within the acceptable error. Still another aspect of the present invention comprises a method for using a protein crystal structure of the present invention in a drag screening assay. In one such embodiment, the method comprises identifying a compound as a potential inhibitor by performing rational drug design with a three-dimensional structure determined for the crystal, preferably in conjunction with computer modeling. Such computer modeling is preferably initiated with a program that incorporates a Docking algorithm (Dunbrack et al, 1997, Folding & Design 2:R27-42). Examples of such programs include DOCK (Kuntz et al, 1982, J. Mol. Biol. 161:269-288), GRID (Goodford, 1985, J. Med. Chem. 28:849-857), AUTODOCK (Goodsell and Olsen, 1990, Proteins: Struct., Fund., Genet. 8:195-202), MCSS (Miranker and Karplus, 1991, Proteins 11:29-34), GOLD (Jones et al, 1995, J Mol Biol 245:43-53), QXP (McMartin and Bohacek, 1997, J. Comput. Aided Molec. Des. 11:333-344), FlexE (Claussen et al, 2001, J Mol Biol 308:377-395), Glide (Shrodinger, Portland, OR), FlexX (Sybl, Tripos, St. Louis, MO) and ICM (Molsoft, San Diego, CA; http://www.molsoft.com). With such programs, one or more compoundsare each brought into contact with a binding site, in this case the ATP binding site, on the ITK kinase domain. The compound binding modes, of which mere may be several for each compound and which both describe the translational and orientational relationships between the protein and that compound and also define the conformation of that compound, are then scored to provide a theoretical guide to the binding affinity of each compound for the particular binding site on the ITK kinase domain. compound is selected as a potential inhibitor based on the scores assigned to its various binding modes to the ITK kinase domain. In a preferred embodiment of this type, a supplemental crystal is grown which comprises a protein-ligand complex formed between an ITK kinase domain and an initial inhibitor. Preferably the crystal effectively diffracts X-rays such that the atomic coordinates of the protein- inhibitor complex can be determined to a resolution of better than 5.0 Angstroms, more preferably better than 3.0 Angstroms. The three-dimensional structure of the supplemental crystal is determined by molecular replacement analysis, multiwavelength anomalous dispersion, multiple isomorphous replacements, or a combination thereof. A new inhibitor with potentially greater binding affinity is then identified by structure-based design techniques using the three-dimensional structure determined for the supplemental crystal, preferably in conjunction with computer modeling. The potentially improved inhibitor is then tested in a protein kinase assay such as the Tec Family Kinase Assay described herein above. All literature and patent references cited in this application are incorporated herein by reference in their entirety. The present invention is not to be limited in scope by the specific embodiments described herein. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and the accompanying figures. Such modifications are intended to fall within the scope of the invention. EXAMPLES
Example 1 : ITK7KD/G354 expressed protein A significant obstacle in the process of obtaining the 3-dimensional structure of a protein by X-ray crystallography is the identification of a protein fragment that is amenable to the formation of protein crystals of suitable quality. Since kinases often have multiple domains, one strategy that increases the likelihood of generating protein crystals of the kinase domain (catalytic) fragment has been to delete the other domains. Furthermore, by making a kinase domain fragment analogous to that of a related kinase for which a crystal structure has been determined, one may further increase the probability of generating suitable protein crystals. Using these concepts, the human ITK/KD/Q343 construct was generated. Theory predicts that a more compactly folded protein has a greater probability of producing high quality protein crystals. Therefore, the human ITK/KD/Q343 construct was subjected to limited proteolysis with trypsin to identify any fragments of the construct that are easily accessible to the protease and are thus likely to be less compactly folded. Using this strategy, the human ITK/KD/G354 and ITK/KD/S361 constructs were designed. To prioritize the three human ITK kinase domain protein fragments for crystallization trials, each was assayed for catalytic activity and for structural foldedness by circular dichroism-monitored thermal denaturation. Both ITK/KD/Q343 and ITK/KD/G354 showed significant catalytic activity, whereas ITK/KD/S361 did not possess activity above background levels (Table 3). In thermal denaturation studies, ITK/KD/G354 had a higher Tm than ITK KD/Q343, suggesting that ITK/KD/G354 is a more stably folded protein. ITK KD/S361 had the highest Tm, but the lack of catalytic activity suggests that this protein may not have a functionally competent catalytic site in the kinase domain. Consequently, the ITK/KD/G354 construct was prioritized for structural studies since it was catalytically active and predicted to be tightly folded. To further increase the probability of obtaining suitable crystals, a murine construct (ITK/KD/G353) analogous to the human ITK/KD/G354 construct was generated. This murine ITK kinase domain construct has 3 conservative and 7 non-conservative amino acid substitutions when compared with the human ITK/KD/G354 construct which may alter the conformation or surface properties of the protein thus providing alternative opportunities for crystal formation.
Table 3 Kinase Kinase Activity * τ ,o~» Construct (Fluorescent Units) m ' ' ITK/KD/Q343 2000 50.0 ITK/KD/G354 910 67.2 ITK/KD/S361 30 72.8
* Using 250 nM enzyme.
Example 2: Preparation of ITK/KD/G354-Compound 4 complex Previously stored at -80°C, human ITK7KD/G354 protein at a concentration between 16 and 30 mg/mL is thawed on ice for 30 min before use. Compound 4, thiophene-2-carboxylic acid [l-(2-carbamoyl-ethyl)-5-(cyclohexanecarbonyl-methyl-amino)-lH-benzoimidazol-2-yl]- amide, is dissolved with dimethyl sulfoxide (DMSO) to a concentration of 50 to 100 mg/mL at room temperature. Protein solution is mixed with a 3 to 5 molar ratio of Compound 4 and incubated on ice for 60 to 90 min. The complex is then diluted to a protein concentration of about 16 mg/mL using an ice-cold solution of 10 to 20 mM 4-(2-hydroxyethyl)-l-piperazine- ethanesulfonic acid (ΗEPES) pΗ 7.5, 100 mM NaCI and 1 mM Tri(2-carboxyethyl)phosphine hydrochloride (TCEP).
Figure imgf000027_0001
Compound 4
Example 3: ITK/KD/G354 protein crystallization Protein crystals are obtained by the vapor diffusion method using hanging drops (McPherson, 1999, Crystallization of Biological Macromolecules, Cold Spring Harbor Laboratory Press, New York) at 4°C. A drop containing the protein is let equilibrate against a reservoir solution in a sealed container. In the present example, a drop is prepared by mixing 2μL of the ITK/KD/G354-Compound 4 complex with lμL of reservoir solution. The reservoir solution contains 5 to 15% PEG 1500, 100 mM sodium citrate pH 5 to 6 and 1 mM TCEP. Crystals typically appear between 3 to 5 weeks after setup and continue to grow to a typical size of 200 to 250 μm within 3 to 5 months. Crystals are soaked with compound 8, N-{5-(cyclohexanecarbonyl-methyl-amino)-l-[3- (4-methyl-piperazin-l-yl)-propyl]-lH-benzoimidazol-2-yl}-4-iodo-benzamide, in the following way. Crystals are transfened to a stabilizing solution containing 35% PEG 1500, lOOmM sodium citrate pΗ 5.30, 1 mM TCEP and 5mM Compound 8. Following an incubation period of 24-36 hrs, crystals are briefly transfened to that same solution containing an added 20% glycerol. The recovered crystals are then frozen in liquid nitrogen and kept frozen until use.
Figure imgf000027_0002
Compound 8 Example 4: ITK/KD/G354-Comρound 4 X-ray diffraction data measurement X-ray diffraction data were measured on ITK/KD/G354-Compound 4 crystals maintained at cryogenic temperature, typically at a value of about -160°C. X-ray diffraction data were measured with X-rays of wavelength 1.0061A at the PX6S beamline of the Swiss Light Source synchrotron using a MAR CCD 165 detector. Data were reduced to integrated intensities using the software D*TREK (Rigaku MSC) and to amplitudes using TRUNCATE (CCP4, 1994, Acta Crystallogr. D 50:760-763). The crystals have a hexagonal unit cell whereby unit cell parameters are limited to a=b≠c and alpha=beta=90° and gamma=T20°. The crystal space group symmetry is 64 and has unit cell dimensions α=b=239.68A, c=97.12A. These unit cell parameters commonly vary by 1 to 2% between samples.
Example 5: Structure determination of the ITK KD/G354-Compound 4 complex The crystal structure of the ITK/KD/G354-Compound 4 complex is determined by molecular replacement method. The structure of a homologous protein, Bruton's Tyrosine Kinase (BTK) catalytic domain (Mao et al., 2001, Journal of Biological Chemistry 276:41435- 41443) is used as a template to solve the ITK KD/G354-Compound 4 crystal structure. BTK atomic coordinates used are publicly available under entry 1K2P at the Protein Databank (Bernstein et al, 1977, Journal of Molecular Biology 112:535-542). An ITK/KD/G354 homology model is prepared with BTK residues A397 to A654 where equivalent ITK KD/G354 residues are modeled in with arbitrary conformations. An initial ITK KD/G354 protein structure is determined by molecular replacement (Rossmann, 1972, The Molecular Replacement Method, Gordon and Breach, New York) using the program AMORE (Navaza, 1994, Acta Qystallogr. A 50:157-163) as implemented in the CCP4 software suite (CCP4, 1994, Acta Qystallogr. D 50:760-763). The ITK/KD/G354 crystal molecular packing contains six protein molecules per asymmetric unit plus an estimated solvent content of 72%. Compound structures are built using Quanta and O, and incorporated with the refinement. Two molecules of Compound 4 and two molecules of Compound 8 are clearly distinguishable and thus included in the refinement. The structure is then refined using the program CNX and is interspaced with model building using the software O (Jones et al, 1991, Acta Qystallogr. A 47:110-119). Refinement statistics are summarized in Table 4. The atomic coordinates are presented in Table 9.
Table 4: Statistics of Crystallographic Data and Structure Refinement
Data collection
Space group P64
Molecules per asymmetric unit 6
Unit cell parameters a=b (A), c (A) 239.68, 97.12
Average mosaicity (°) 0.42 all outer shell
Resolution (A) 45.8 to 3.0 3.11 to 3.00
Observed measurements 364030 36179
Unique reflections 63877 6324
Completeness (%) 98.2 98.9
Average II σi 7.8 2.2
R a 0.122 0.419
Refinement
Resolution (A) 45.8 to 3.0
-Kfacto reflections used 0.31, 58143
Free R- value0, reflections used 0.37, 3092
R.m.s.d.d bond lengths (A) 0.010
R.m.s.d. bond angles (°) 1.48 a) Rsym = ∑ - <■!> / ∑ Ii where /,■ is the scaled intensity of the z'th measurement and <I> is the mean intensity for that reflection. b) Rfactor = ∑ lEobs - Ecaicl / ∑ |Eobs| where E0bs and Ecaic are the observed and calculated structure factor amplitudes, respectively. c) Free R-value is the i?factor calculated from a set of reflections that are never used with the refinement. These reflections are used as a control set to pursue the refinement progress. d) R.m.s.d. is the root mean square deviation from ideal geometry. Standard stereochemical parameters (Engh and Huber, 1991, Acta Crystallogr. A 47:392-400) were used with the refinement. nxample 6: Similarity between the kinase domains of ITK and other kinases To establish a measurement for the similarity between the kinase domains of ITK and other kinases, the following experiments were performed. Four sets of residues (RES-SETl, RES- SET2, RES-SET3, and RES-SET4) were identified by visual inspection of the ITK/KD/G354- Compound 4 structure as both being spatially proximal to the ATP binding site and as comprising distinct combinations of subregions within this site. These residue sets are defined in Table 5. The first set of residues (RES-SETl) comprises those residues which are located in the ATP binding site of ITK (i.e., V377, A389, K391, V419, 1433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489); those residues which form the surface-exposed hydrophobic pocket (i.e., Q367, 1369, L379, K387) into which the cyclohexyl moiety of Compound 4 binds; and those residues which are located in the G-loop (i.e., G370, S371), near the DFG-motif (i.e., S499, D500, F501), and near the kinase specificity pocket (i.e., A406, M410). The second set of residues (RES-SET2) comprises those residues which are located in the ATP binding site of ITK; and those residues which are located in the G-loop, near the DFG- motif, and near the kinase specificity pocket, as previously defined for the RES-SETl residue set. The third set of residues (RES-SET3) comprises those residues which are located in the ATP binding site of ITK, as previously defined for the RES-SETl residue set. The fourth set of residues (RES-SET4) comprises those residues which are located in the ATP binding site of ITK and those residues which form the surface-exposed hydrophobic pocket, as previously defined for the RES-SETl residue set.
Table 5: Definition of residue sets.
RES-SETl : V377, A389, K391, V419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501, Q367, 1369, L379, K387 RES-SET2: V377, A389, K391, V419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501 RES-SET3: V377, A389, K391, V419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489 RES-SET4: V377, A389, K391, V419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489,Q367, 1369, L379, K387
The residue numbering in Table 5 is based on the position of that residue in full-length human ITK kinase. An alignment of the human ITK kinase domain with other lαiown human kinase domain sequences was performed. The parts of this alignment that pertain to the aforedescribed 4 residue sets are presented in Table 10. Based on these partial sequence alignments, the sequence identities over these four residue sets were calculated between human ITK and each of the other presented human kinases. Table 6 lists, for each residue set, the kinase with the highest identity to human ITK and the associated percent identity, the kinase with the highest identity for which a structure is available and the associated percent identity, and the percent identities to human BTK, TXK, EGFR, and LCK kinases. Table 6: Percent sequence identities* between human ITK and other human Kinases
Kinase with Kmase with si&mi"la«rity BTK TXK EGFR LCK
Figure imgf000033_0001
RES-SETl 85 TXK 73 CSK 66 85 62 58
RES-SET2 87 TEC 73 BTK 73 87 69 64
RES-SET3 80 TEC 67 BTK 67 80 60 60
RES-SET4 79 TXK 69 CSK 58 79 53 3 aBased on the partial sequence alignments presented in Table 10
As a second measurement of similarity between the kinase domain of human ITK and that of other select human kinases, the backbone RMSDs have been calculated for ITK vs. BTK, ITK vs. EGFR, and ITK vs. LCK. Also the backbone RMSDs were calculated between the A and the B chain of the BTK structure to probe for the variability within a protein structure. The structures were taken from the Protein Databank entries 1K2P (BTK), 1M17 (EGFR), and IQPJ (LCK). These crystal structures have respective resolutions of 2.1 A, 2.2A, and 2.6A. The RMSDs are calculated by separately performing an alignment of the backbone atoms for the residues in each of the four residue sets and then measuring the RMSDs. This was done using the software program INSIGHT (Accelrys). Table 7: Backbone RMSDs for the four residue sets
ITK vs BTK ITK : vs EGFR ITK vs LCK BTK A vs BTK B RES-SETl 1.80 1.09 0.79 1.17 RES-SET2 1.75 1.13 0.74 1.14 RES-SET3 1.08 0.61 0.60 0.74 RES-SET4 0.57 0.50 0.47 0.32
The alignment for the RMSD measurements differed from that used in the sequence identity analysis in that K387 of ITK was aligned with D426 of BTK, or with P717 of EGFR. All other residues were aligned h the same way. The polypeptide binding pocket consisting of residues Q367, 1369, L379, K387, and F437 of SEQ ID NO. 1 has a backbone-atom R.m.s.d. of 0.42 Angstroms to the conesponding residues in LCK, 0.55 Angstroms to the conesponding residues in EGFR, and 1.42 Angstroms to the conesponding residues in BTK. The RMSD is measured as described above.
A third analysis of similarity was performed between the kinase domain of human ITK and that of the 3 known ITK orthologs. The sequences for human, rat, mouse, and zebrafish were aligned as shown in Figure 5. The sequence similarities were then calculated for the four residue sets and are presented in see Table 9.
Table 8: Percent sequence identity between the kinase domain of human ITK and that of each known ITK ortholog
ITK rat ITK mouse ITK zebrafish RES-SETl 100 100 77 RES-SET2 100 100 91 RES-SET3 100 100 93 RES-SET4 100 100 74
Example 7: Murine ITK/KD/G353-ITK Inhibitor Complex Formation, Crystallization and X-ray Diffraction
A solution of murine ITK KD/G353 protein (SEQ ID NO. 16) at a concentration of 10 to 31.5 mg/mL, previously frozen at -80°C is thawed on ice for 30 minutes before use. A suitable compound which inhibits ITK, is dissolved with dimethyl sulfoxide (DMSO) to a concentration ot iυυ mg/mL at room temperature. The ITK inhibitor is mixed with the protein solution at 5 molar ratio of inhibitor to protein. The mixture is incubated on ice for 60 to 90 minutes.
Protein crystals are obtained by vapor diffusion methos using hanging drops at room temperature. A drop containing ITK/KD/G353-ITK inhibitor complex is let to equilibrate against a reservoir solution in a sealed container, hi the present example, a hanging drop is prepared by mixing lμL of the ITK/KD/G353- ITK inhibitor with an equal volume of reservoir solution. The reservoir solution contains 10 to 18% polyethyleneglycol 5000 monomethylether, 100 mM sodium citrate pH 5 to 6 and 1 mM TCEP.
An ITK/KD/G353- ITK inhibitor crystal is transfened to a stabilizing solution containing
20% polyethyleneglycol 5000 monomethylether, 100 mM sodium citrate pH 5.5, 1 mM TCEP,
25% glycerol and 20 mM ITK inhibitor. The crystal is flash-frozen in a cold stream at cryogenic temperature of about -160°C. X-ray diffraction data are measured with an RU-H3R rotating anode-based generator (Rigaku/MSC) operating at 50 kV/60 mA equipped with an R-
Axis-IV++ detector (Rigaku/MSC) and confocal blue optics (Osmics). X-ray diffraction data to
4 A resolution are reduced with a combination of DENZO and SCALEPACK (Otwinowski and
Minor, 1997, Meth. Enzymol. 276:307-326) and TRUNCATE (CCP4, 1994, Acta Crystallogr. D
50:760-763).
The crystal has a tetragonal unit cell whereby unit cell parameters are limited to a=b≠c and alpha=beta=gamma=90°. The crystal space group symmetry is 4 2]2 and has unit cell dimensions α=b=98.78θA, c=122.408A. These unit cell parameters commonly vary by 1 to 2% between samples. The crystal has an estimated solvent content of about 75% and one protein assembly per asymmetric unit. Tabl e 9 Atomi c coordi nates of the Six ITK Mol ecul e complexes Obtai ned by X-ray Di fraction Analysi s
Atom Residue X y z Occ. B Molecule No Type Type NO
ATOM 1 CB SER 361 54.699 51.147 21.644 1.00 33.48 A
ATOM 2 OG SER 361 54.182 51.268 22.965 1.00 33.48 A
ATOM 3 C SER 361 54.092 53.529 21.734 1.00 33.48 A
ATOM 4 0 SER 361 53.007 53.755 22.268 1.00 33.48 A
ATOM 5 N SER 361 55.186 52.544 19.630 1.00 33.48 A
ATOM 6 CA SER 361 54.254 52.340 20.792 1.00 33.48 A
ATOM 7 N GLU 362 55.177 54.263 21.961 1.00 33.48 A
ATOM 8 CA GLU 362 55.164 55.421 22.857 1.00 33.48 A
ATOM 9 CB GLU 362 56.600 55.954 23.009 1.00 33.48 A
ATOM 10 CG GLU 362 57.647 54.810 23.097 1.00 33.48 A
ATOM 11 CD GLU 362 59.100 55.285 23.269 1.00 33.48 A
ATOM 12 OEl GLU 362 60.004 54.408 23.258 1.00 33.48 A
ATOM 13 OE2 GLU 362 59.334 56.516 23.420 1.00 33.48 A
ATOM 14 C GLU 362 54.225 56.519 22.323 1.00 33.48 A
ATOM 15 0 GLU 362 54.219 57.663 22.823 1.00 33.48 A
ATOM 16 N LEU 363 53.431 56.153 21.314 1.00 33.48 A
ATOM 17 CA LEU 363 52.476 57.059 20.674 1.00 33.48 A
ATOM 18 CB LEU 363 52.385 56.730 19.188 1.00 33.48 A
ATOM 19 CG LEU 363 52.143 57.860 18.191 1.00 33.48 A
ATOM 20 CDl LEU 363 53.509 58.418 17.761 1.00 33.48 A
ATOM 21 CD2 LEU 363 51.357 57.333 16.969 1.00 33.48 A
ATOM 22 C LEU 363 51.082 56.913 21.298 1.00 33.48 A
ATOM 23 0 LEU 363 50.705 55.829 21.755 1.00 33.48 A
ATOM 24 N THR 364 50.315 58.001 21.306 1.00 33.48 A
ATOM 25 CA THR 364 48.964 57.973 21.858 1.00 33.48 A
ATOM 26 CB THR 364 48.941 58.271 23.384 1.00 33.48 A
ATOM 27 OGl THR 364 47.936 59.263 23.669 1.00 33.48 A
ATOM 28 CG2 THR 364 50.320 58.744 23.865 1.00 33.48 A
ATOM 29 C THR 364 48.079 58.984 21.166 1.00 33.48 A
ATOM 30 0 THR 364 48.283 60.194 21.277 1.00 33.48 A
ATOM 31 N PHE 365 47.093 58.468 20.445 1.00 33.48 A
ATOM 32 CA PHE 365 46^147 59.300 19.713 1.00 33.48 A
ATOM 33 CB PHE 365 45.314 58.438 18.766 1.00 33.48 A
ATOM 34 CG PHE 365 46.119 57.847 17.654 1.00 33.48 A
ATOM 35 CDl PHE 365 46.066 58.379 16.383 1.00 33.48 A
ATOM 36 CD2 PHE 365 47.003 56.819 17.903 1.00 33.48 A
ATOM 37 CEl PHE 365 46.892 57.897 15.379 1.00 33.48 A
ATOM 38 CE2 PHE 365 47.833 56.330 16.903 1.00 33.48 A ATOM 39 CZ PHE 365 47.780 56.870 15.641 1.00 33.48 A
ATOM 40 C PHE 365 45.264 60.023 20.695 1.00 33.48 A
ATOM 41 O PHE 365 45.190 59.638 21.870 1.00 33.48 A
ATOM 42 N VAL 366 44.610 61.079 20.222 1.00 33.48 A
ATOM 43 CA VAL 366 43.748 61.866 21.085 1.00 33.48 A
ATOM 44 CB VAL 366 44.533 62.974 21.795 1.00 33.48 A
ATOM 45 CGI VAL 366 43.593 63.802 22.661 1.00 33.48 A
ATOM 46 CG2 VAL 366 45.638 62.367 22.646 1.00 33.48 A
ATOM 47 C VAL 366 42.593 62.519 20.360 1.00 33.48 A
ATOM 48 O VAL 366 41.589 62.866 20.989 1.00 33.48 A
ATOM 49 N GLN 367 42.723 62.700 19.046 1.00 33.48 A
ATOM 50 CA GLN 367 41.637 63.322 18.286 1.00 33.48 A
ATOM 51 CB GLN 367 41.321 64.714 18.851 1.00 33.48 A
ATOM 52 CG GLN 367 39.998 65.270 18.335 1.00 33.48 A
ATOM 53 CD GLN 367 39.786 66.736 18.680 1.00 33.48 A
ATOM 54 OEl GLN 367 40.037 67.163 19.810 1.00 33.48 A
ATOM 55 NE2 GLN 367 39.303 67.513 17.707 1.00 33.48 A
ATOM 56 C GLN 367 41.867 63.453 16.780 1.00 33.48 A
ATOM 57 O GLN 367 42.989 63.321 16.286 1.00 33.48 A
ATOM 58 N GLU 368 40.784 63.726 16.057 1.00 33.48 A
ATOM 59 CA GLU 368 40.854 63.903 14.612 1.00 33.48 A
ATOM 60 CB GLU 368 39.591 63.368 13.939 1.00 33.48 A
ATOM 61 CG GLU 368 39.655 63.437 12.405 1.00 33.48 A
ATOM 62 CD GLU 368 38.275 63.442 11.767 1.00 33.48 A
ATOM 63 OEl GLU 368 37.689 64.542 11.593 1.00 33.48 A
ATOM 64 OE2 GLU 368 37.775 62.340 11.445 1.00 33.48 A
ATOM 65 C GLU 368 40.972 65.396 14.305 1.00 33.48 A
ATOM 66 O GLU 368 39.971 66.136 14.347 1.00 33.48 A
ATOM 67 N ILE 369 42.191 65.838 14.011 1.00 33.48 A
ATOM 68 CA ILE 369 42.413 67.236 13.685 1.00 33.48 A
ATOM 69 CB ILE 369 43.914 67.594 13.640 1.00 33.48 A
ATOM 70 CG2 ILE 369 44.426 67.884 15.038 1.00 33.48 A
ATOM 71 CGI ILE 369 44.694 66.456 12.968 1.00 33.48 A
ATOM 72 CDl ILE 369 46.192 66.656 12.898 1.00 33.48 A
ATOM 73 C ILE 369 41.814 67.489 12.316 1.00 33.48 A
ATOM 74 O ILE 369 40.960 68.370 12.178 1.00 33.48 A
ATOM 75 N GLY 370 42.232 66.713 11.309 1.00 33.48 A
ATOM 76 CA GLY 370 41.704 66.926 9.964 1.00 33.48 A
ATOM 77 C GLY 370 41.873 65.850 8.888 1.00 33.48 A
ATOM 78 O GLY 370 42.685 64.910 9.009 1.00 33.48 A
ATOM 79 N SER 371 41.099 65.998 7.809 1.00 33.48 A
ATOM 80 CA SER 371 41.138 65.042 6.700 1.00 33.48 A
ATOM 81 CB SER 371 40.015 65.316 5.706 1.00 33.48 A
ATOM 82 OG SER 371 40.227 64.530 4.547 1.00 33.48 A ATOM 83 C SER 371 42.469 65.038 5.958 1.00 33.48 A
ATOM 84 O SER 371 43.136 66.073 5.848 1.00 33.48 A
ATOM 85 N GLY 372 42.844 63.876 5.427 1.00 33.48 A
ATOM 86 CA GLY 372 44.122 63.783 4.739 1.00 33.48 A
ATOM 87 C GLY 372 44.124 63.561 3.237 1.00 33.48 A
ATOM 88 O GLY 372 43.242 62.895 2.686 1.00 33.48 A
ATOM 89 N GLN 373 45.132 64.118 2.571 1.00 33.48 A
ATOM 90 CA GLN 373 45.277 63.962 1.132 1.00 33.48 A
ATOM 91 CB GLN 373 46.128 65.105 0.566 1.00 33.48 A
ATOM 92 CG GLN 373 45.471 66.496 0.695 1.00 33.48 A
ATOM 93 CD GLN 373 43.990 66.541 0.220 1.00 33.48 A
ATOM 94 OEl GLN 373 43.345 67.606 0.269 1.00 33.48 A
ATOM 95 NE2 GLN 373 43.454 65.390 -0.229 1.00 33.48 A
ATOM 96 C GLN 373 45.874 62.599 0.732 1.00 33.48 A
ATOM 97 O GLN 373 46.552 62.487 -0.297 1.00 33.48 A
ATOM 98 N PHE 374 45.625 61.582 1.566 1.00 33.48 A
ATOM 99 CA PHE 374 46.068 60.199 1.336 1.00 33.48 A
ATOM 100 CB PHE 374 47.400 60.149 0.576 1.00 33.48 A
ATOM 101 CG PHE 374 48.583 60.634 1.361 1.00 33.48 A
ATOM 102 CDl PHE 374 49.852 60.604 0.794 1.00 33.48 A
ATOM 103 CD2 PHE 374 48.438 61.107 2.655 1.00 33.48 A
ATOM 104 CEl PHE 374 50.971 61.044 1.509 1.00 33.48 A
ATOM 105 CE2 PHE 374 49.546 61.546 3.381 1.00 33.48 A
ATOM 106 CZ PHE 374 50.821 61.515 2.807 1.00 33.48 A
ATOM 107 C PHE 374 46.177 59.378 2.625 1.00 33.48 A
ATOM 108 0 PHE 374 47.049 58.515 2.751 1.00 33.48 A
ATOM 109 N GLY 375 45.275 59.653 3.565 1.00 33.48 A
ATOM 110 CA GLY 375 45.241 58.962 4.847 1.00 33.48 A
ATOM 111 C GLY 375 44.580 59.934 5.809 1.00 33.48 A
ATOM 112 0 GLY 375 43.708 60.718 5.396 1.00 33.48 A
ATOM 113 N LEU 376 44.963 59.916 7.080 1.00 33.48 A
ATOM 114 CA LEU 376 44.367 60.887 7.984 1.00 33.48 A
ATOM 115 CB LEU 376 43.124 60.299 8.666 1.00 33.48 A
ATOM 116 CG LEU 376 41.970 61.306 8.546 1.00 33.48 A
ATOM 117 CDl LEU 376 41.512 61.363 7.086 1.00 33.48 A
ATOM 118 CD2 LEU 376 40.805 60.927 9.468 1.00 33.48 A
ATOM 119 C LEU 376 45.364 61.410 9.017 1.00 33.48 A
ATOM 120 0 LEU 376 46.354 60.733 9.336 1.00 33.48 A
ATOM 121 N VAL 377 45.119 62.630 9.506 1.00 33.48 A
ATOM 122 CA VAL 377 45.987 63.232 10.517 1.00 33.48 A
ATOM 123 CB VAL 377 46.609 64.573 10.042 1.00 33.48 A
ATOM 124 CGl VAL 377 47.461 64.329 8.826 1.00 33.48 A
ATOM 125 CG2 VAL 377 45.524 65.599 9.739 1.00 33.48 A
ATOM 126 C VAL 377 45.227 63.466 11.818 1.00 33.48 A ATOM 127 O VAL 377 44.116 64.005 11.821 1.00 33..48 A
ATOM 128 N HIS 378 45.841 63.061 12.927 1.00 33. .48 A
ATOM 129 CA HIS 378 45.210 63.194 14.234 1.00 33. ,48 A
ATOM 130 CB HIS 378 44.922 61.817 14.847 1.00 33. .48 A
ATOM 131 CG HIS 378 44.632 60.744 13.847 1.00 33. ,48 A
ATOM 132 CD2 HIS 378 43.667 59.794 13.819 1.00 33. .48 A
ATOM 133 NDl HIS 378 45.421 60.526 12.734 1.00 33. .48 A
ATOM 134 CEl HIS 378 44.950 59.492 12.059 1.00 33. .48 A
ATOM 135 NE2 HIS 378 43.886 59.030 12.696 1.00 33. .48 A
ATOM 136 C HIS 378 46.087 63.939 15.215 1.00 33. .48 A
ATOM 137 O HIS 378 47.315 63.871 15.158 1.00 33. .48 A
ATOM 138 N LEU 379 45.434 64.638 16.130 1.00 33. .48 A
ATOM 139 CA LEU 379 46.142 65.354 17.168 1.00 33. .48 A
ATOM 140 CB LEU 379 45.223 66.378 17.823 1.00 33, .48 A
ATOM 141 CG LEU 379 45.789 67.029 19.079 1.00 33, .48 A
ATOM 142 CDl LEU 379 47.224 67.501 18.837 1.00 33, .48 A
ATOM 143 CD2 LEU 379 44.882 68.182 19.477 1.00 33, .48 A
ATOM 144 C LEU 379 46.471 64.255 18.153 1.00 33, .48 A
ATOM 145 0 LEU 379 45.656 63.354 18.365 1.00 33, .48 A
ATOM 146 N GLY 380 47.657 64.303 18.745 1.00 33, .48 A
ATOM 147 CA GLY 380 48.008 63.269 19.700 1.00 33, .48 A
ATOM 148 C GLY 380 49.278 63.590 20.443 1.00 33, .48 A
ATOM 149 0 GLY 380 50.157 64.275 19.917 1.00 33, .48 A
ATOM 150 N TYR 381 49.378 63.092 21.671 1.00 33, .48 A
ATOM 151 CA TYR 381 50.568 63.329 22.494 1.00 33, .48 A
ATOM 152 CB TYR 381 50.180 63.369 23.987 1.00 33, .48 A
ATOM 153 CG TYR 381 49.608 64.704 24.403 1.00 33, .48 A
ATOM 154 CDl TYR 381 50.433 65.813 24.542 1.00 33 .48 A
ATOM 155 CEl TYR 381 49.905 67.069 24.841 1.00 33 .48 A
ATOM 156 CD2 TYR 381 48.231 64.877 24.577 1.00 33 .48 A
ATOM 157 CE2 TYR 381 47.685 66.130 24.872 1.00 33 .48 A
ATOM 158 CZ TYR 381 48.526 67.226 25.002 1.00 33 .48 A
ATOM 159 OH TYR 381 48.010 68.483 25.271 1.00 33 .48 A
ATOM 160 C TYR 381 51.640 62.269 22.251 1.00 33 .48 A
ATOM 161 0 TYR 381 51.368 61.066 22.351 1.00 33 .48 A
ATOM 162 N TRP 382 52.851 62.706 21.913 1.00 33 .48 A
ATOM 163 CA TRP 382 53.920 61.744 21.681 1.00 33 .48 A
ATOM 164 CB TRP 382 54.804 62.142 20.494 1.00 33 .48 A
ATOM 165 CG TRP 382 56.109 61.367 20.443 1.00 33 .48 A
ATOM 166 CD2 TRP 382 57.427 61.895 20.200 1.00 33 .48 A
ATOM 167 CE2 TRP 382 58.331 60.815 20.274 1.00 33 .48 A
ATOM 168 CE3 TRP 382 57.928 63.175 19.929 1.00 33 .48 A
ATOM 169 CDl TRP 382 56.271 60.027 20.640 1.00 33 .48 A
ATOM 170 NEl TRP 382 57.601 59.688 20.546 1.00 33 .48 A ATOM 171 CZ2 TRP 382 59.705 60.973 20.088 1.00 33.48 A
ATOM 172 CZ3 TRP 382 59.295 63.332 19.747 1.00 33.48 A
ATOM 173 CH2 TRP 382 60.166 62.236 19.828 1.00 33.48 A
ATOM 174 C TRP 382 54.800 61.520 22.899 1.00 33.48 A
ATOM 175 0 TRP 382 55.058 62.438 23.691 1.00 33.48 A
ATOM 176 N LEU 383 55.234 60.269 23.038 1.00 33.48 A
ATOM 177 CA LEU 383 56.099 59.845 24.123 1.00 33.48 A
ATOM 178 CB LEU 383 57.538 60.281 23.842 1.00 33.48 A
ATOM 179 CG LEU 383 58.545 59.187 24.213 1.00 33.48 A
ATOM 180 CDl LEU 383 59.956 59.601 23.752 1.00 33.48 A
ATOM 181 CD2 LEU 383 58.476 58.917 25.724 1.00 33.48 A
ATOM 182 C LEU 383 55.629 60.433 25.443 1.00 33.48 A
ATOM 183 0 LEU 383 54.561 60.072 25.947 1.00 33.48 A
ATOM 184 N ASN 384 56.430 61.343 25.989 1.00 33.48 A
ATOM 185 CA ASN 384 56.105 61.994 27.250 1.00 33.48 A
ATOM 186 CB ASN 384 57.212 62.977 27.633 1.00 33.48 A
ATOM 187 CG ASN 384 58.608 62.369 27.507 1.00 33.48 A
ATOM 188 ODl ASN 384 58.965 61.786 26.465 1.00 33.48 A
ATOM 189 ND2 ASN 384 59.411 62.510 28.566 1.00 33.48 A
ATOM 190 C ASN 384 54.794 62.760 27.109 1.00 33.48 A
ATOM 191 0 ASN 384 53.695 62.227 27.347 1.00 33.48 A
ATOM 192 N ALA 385 54.914 64.024 26.728 1.00 33.48 A
ATOM 193 CA ALA 385 53.733 64.849 26.564 1.00 33.48 A
ATOM 194 CB ALA 385 53.345 65.513 27.905 1.00 33.48 A
ATOM 195 C ALA 385 53.974 65.903 25.483 1.00 33.48 A
ATOM 196 0 ALA 385 53.419 67.014 25.532 1.00 33.48 A
ATOM 197 N ASP 386 54.811 65.558 24.508 1.00 33.48 A
ATOM 198 CA ASP 386 55.080 66.461 23.401 1.00 33.48 A
ATOM 199 CB ASP 386 56.346 66.022 22.666 1.00 33.48 A
ATOM 200 CG ASP 386 57.178 67.202 22.186 1.00 33.48 A
ATOM 201 ODl ASP 386 57.247 68.199 22.949 1.00 33.48 A
ATOM 202 OD2 ASP 386 57.771 67.138 21.072 1.00 33.48 A
ATOM 203 C ASP 386 53.844 66.385 22.482 1.00 33.48 A
ATOM 204 0 ASP 386 53.507 65.322 21.947 1.00 33.48 A
ATOM 205 N LYS 387 53.150 67.512 22.344 1.00 33.48 A
ATOM 206 CA LYS 387 51.950 67.634 21.523 1.00 33.48 A
ATOM 207 CB LYS 387 51.323 68.998 21.765 1.00 33.48 A
ATOM 208 CG LYS 387 49.830 69.023 21.628 1.00 33.48 A
ATOM 209 CD LYS 387 49.296 70.277 22.261 1.00 33.48 A
ATOM 210 CE LYS 387 47.841 70.154 22.609 1.00 33.48 A
ATOM 211 NZ LYS 387 47.442 71.263 23.521 1.00 33.48 A
ATOM 212 C LYS 387 52.348 67.506 20.060 1.00 33.48 A
ATOM 213 0 LYS 387 52.945 68.422 19.504 1.00 33.48 A
ATOM 214 N VAL 388 51.996 66.393 19.430 1.00 33.48 A ATOM 215 CA VAL 388 52.393 66.165 18.047 1.00 33.48 A
ATOM 216 CB VAL 388 53.318 64.963 17.940 1.00 33.48 A
ATOM 217 CGI VAL 388 54.385 65.047 18.997 1.00 33.48 A
ATOM 218 CG2 VAL 388 52.515 63.689 18.063 1.00 33.48 A
ATOM 219 C VAL 388 51.261 65.915 17.072 1.00 33.48 A
ATOM 220 0 VAL 388 50.088 65.859 17.445 1.00 33.48 A
ATOM 221 N ALA 389 51.632 65.750 15.808 1.00 33.48 A
ATOM 222 CA ALA 389 50.664 65.489 14.759 1.00 33.48 A
ATOM 223 CB ALA 389 50.742 66.548 13.710 1.00 33.48 A
ATOM 224 C ALA 389 50.921 64.120 14.148 1.00 33.48 A
ATOM 225 0 ALA 389 52.054 63.792 13.770 1.00 33.48 A
ATOM 226 N ILE 390 49.856 63.328 14.050 1.00 33.48 A
ATOM 227 CA ILE 390 49.938 61.986 13.492 1.00 33.48 A
ATOM 228 CB ILE 390 49.321 60.966 14.457 1.00 33.48 A
ATOM 229 CG2 ILE 390 50.210 59.741 14.520 1.00 33.48 A
ATOM 230 CGI ILE 390 49.263 61.537 15.864 1.00 33.48 A
ATOM 231 CDl ILE 390 50.576 61.429 16.615 1.00 33.48 A
ATOM 232 C ILE 390 49.224 61.888 12.145 1.00 33.48 A
ATOM 233 0 ILE 390 48.008 62.098 12.031 1.00 33.48 A
ATOM 234 N LYS 391 50.007 61.548 11.132 1.00 33.48 A
ATOM 235 CA LYS 391 49.548 61.414 9.768 1.00 33.48 A
ATOM 236 CB LYS 391 50.526 62.161 8.894 1.00 33.48 A
ATOM 237 CG LYS 391 50.018 62.738 7.623 1.00 33.48 A
ATOM 238 CD LYS 391 51.206 63.417 6.945 1.00 33.48 A
ATOM 239 CE LYS 391 50.839 64.190 5.699 1.00 33.48 • A
ATOM 240 NZ LYS 391 49.906 65.264 6.142 1.00 33.48 A
ATOM 241 C LYS 391 49.497 59.907 9.402 1.00 33.48 A
ATOM 242 0 LYS 391 50.538 59.238 9.318 1.00 33.48 A
ATOM 243 N THR 392 48.268 59.392 9.206 1.00 33.48 A
ATOM 244 CA THR 392 48.062 57.969 8.874 1.00 33.48 A
ATOM 245 CB THR 392 47.041 57.253 9.853 1.00 33.48 A
ATOM 246 OGl THR 392 45.717 57.829 9.707 1.00 33.48 A
ATOM 247 CG2 THR 392 47.514 57.358 11.332 1.00 33.48 A
ATOM 248 C THR 392 47.570 57.741 7.445 1.00 33.48 A
ATOM 249 0 THR 392 46.352 57.688 7.189 1.00 33.48 A
ATOM 250 N PHE 403 58.954 55.391 0.069 1.00 33.48 A
ATOM 251 CA PHE 403 58.767 55.692 1.489 1.00 33.48 A
ATOM 252 CB PHE 403 58.226 54.468 2.229 1.00 33.48 A
ATOM 253 CG PHE 403 58.119 54.676 3.713 1.00 33.48 A
ATOM 254 CDl PHE 403 57.213 55.601 4.236 1.00 33.48 A
ATOM 255 CD2 PHE 403 58.945 53.991 4.586 1.00 33.48 A
ATOM 256 CEl PHE 403 - 57.134 55.842 5.609 1.00 33.48 A
ATOM 257 CE2 PHE 403 58.872 54.229 5.961 1.00 33.48 A
ATOM 258 CZ PHE 403 57.962 55.158 6.470 1.00 33.48 A ATOM 259 C PHE 403 60.031 56.165 2.221 1.00 33.48 A
ATOM 260 0 PHE 403 59.954 57.013 3.110 1.00 33.48 A
ATOM 261 N ILE 404 61.184 55.595 1.871 1.00 33.48 A
ATOM 262 CA ILE 404 62.447 55.952 2.518 1.00 33.48 A
ATOM 263 CB ILE 404 63.468 54.842 2.377 1.00 33.48 A
ATOM 264 CG2 ILE 404 64.815 55.301 2.952 1.00 33.48 A
ATOM 265 CGI ILE 404 62.959 53.609 3.107 1.00 33.48 A
ATOM 266 CDl ILE 404 62.650 53.880 4.562 1.00 33.48 A
ATOM 267 C ILE 404 63.076 57.212 1.956 1.00 33.48 A
ATOM 268 0 ILE 404 63.326 58.181 2.681 1.00 33.48 A
ATOM 269 N GLU 405 63.379 57.173 0.664 1.00 33.48 A
ATOM 270 CA GLU 405 63.954 58.330 0.002 1.00 33.48 A
ATOM 271 CB GLU 405 63.702 58.223 -1.506 1.00 33.48 A
ATOM 272 CG GLU 405 64.191 56.909 -2.127 1.00 33.48 A
ATOM 273 CD GLU 405 63.894 56.789 -3.619 1.00 33.48 A
ATOM 274 OEl GLU 405 64.134 57.760 -4.371 1.00 33.48 A
ATOM 275 OE2 GLU 405 63.431 55.712 -4.053 1.00 33.48 A
ATOM 276 C GLU 405 63.212 59.522 0.599 1.00 33.48 A
ATOM 277 0 GLU 405 63.820 60.444 1.166 1.00 33.48 A
ATOM 278 N GLU 406 61.887 59.466 0.522 1.00 33.48 A
ATOM 279 CA GLU 406 61.053 60.533 1.059 1.00 33.48 A
ATOM 280 CB GLU 406 59.570 60.176 0.878 1.00 33.48 A
ATOM 281 CG GLU 406 59.276 59.238 -0.308 1.00 33.48 A
ATOM 282 CD GLU 406 58.658 59.965 -1.506 1.00 33.48 A
ATOM 283 OEl GLU 406 57.731 60.782 -1.295 1.00 33.48 A
ATOM 284 OE2 GLU 406 59.063 59.726 -2.662 1.00 33.48 A
ATOM 285 C GLU 406 61.390 60.702 2.544 1.00 33.48 A
ATOM 286 0 GLU 406 61.617 61.822 3.010 1.00 33.48 A
ATOM 287 N ALA 407 61.433 59.599 3.284 1.00 33.48 A
ATOM 288 CA ALA 407 61.754 59.644 4.709 1.00 33.48 A
ATOM 289 CB ALA 407 61.714 58.231 5.306 1.00 33.48 A
ATOM 290 C ALA 407 63.155 60.225 4.817 1.00 33.48 A
ATOM 291 0 ALA 407 63.373 61.328 5.376 1.00 33.48 A
ATOM 292 N GLU 408 64.112 59.509 4.250 1.00 33.48 A
ATOM 293 CA GLU 408 65.487 59.942 4.277 1.00 33.48 A
ATOM 294 CB GLU 408 66.256 59.338 3.089 1.00 33.48 A
ATOM 295 CG GLU 408 67.764 59.318 3.288 1.00 33.48 A
ATOM 296 CD GLU 408 68.228 57.992 3.825 1.00 33.48 A
ATOM 297 OEl GLU 408 67.826 57.614 4.959 1.00 33.48 A
ATOM 298 OE2 GLU 408 68.995 57.320 3.094 1.00 33.48 A
ATOM 299 C GLU 408 65.501 61.476 4.164 1.00 33.48 A
ATOM 300 0 GLU 408 66.242 62.166 4.871 1.00 33.48 A
ATOM 301 N VAL 409 64.661 62.009 3.281 1.00 33.48 A
ATOM 302 CA VAL 409 64.599 63.449 3.078 1.00 33.48 A ATOM 3O3 CB VAL 409 63.594 63.816 1.949 1.00 33.48 A
ATOM 3O4 CGl VAL 409 63.496 65.332 1.811 1.00 33.48 A
ATOM 305 CG2 VAL 409 64.028 63.170 0.623 1.00 33.48 A
ATOM 306 C VAL 409 64.221 64.231 4.347 1.00 33.48 A
ATOM 307 0 VAL 409 65.090 64.808 4.999 1.00 33.48 A
ATOM 308 N MET 410 62.939 64.261 4.693 1.00 33.48 A
ATOM 309 CA MET 410 62.489 64.981 5.885 1.00 33.48 A
ATOM 310 CB MET 410 61.216 64.329 6.392 1.00 33.48 A
ATOM 311 CG MET 410 60.348 63.934 5.245 1.00 33.48 A
ATOM 312 SD MET 410 58.739 63.464 5.801 1.00 33.48 A
ATOM 313 CE MET 410 57.816 65.043 5.420 1.00 33.48 A
ATOM 314 C MET 410 63.549 65.000 6.993 1.00 33.48 A
ATOM 315 0 MET 410 64.053 66.061 7.350 1.00 33.48 A
ATOM 316 N MET 411 63.887 63.835 7.532 1.00 33.48 A
ATOM 317 CA MET 411 64.908 63.748 8.568 1.00 33.48 A
ATOM 318 CB MET 411 65.437 62.322 8.622 1.00 33.48 A
ATOM 319 CG MET 411 65.628 61.713 7.256 1.00 33.48 A
ATOM 320 SD MET 411 65.496 59.910 7.356 1.00 33.48 A
ATOM 321 CE MET 411 66.963 59.506 8.459 1.00 33.48 A
ATOM 322 C MET 411 66.075 64.703 8.320 1.00 33.48 A
ATOM 323 0 MET 411 66.325 65.632 9.100 1.00 33.48 A
ATOM 324 N LYS 412 66.789 64.459 7.226 1.00 33.48 A
ATOM 325 CA LYS 412 67.931 65.277 6.839 1.00 33.48 A
ATOM 326 CB LYS 412 68.242 65.058 5.348 1.00 33.48 A
ATOM 327 CG LYS 412 69.625 65.557 4.890 1.00 33.48 A
ATOM 328 CD LYS 412 70.712 64.480 5.102 1.00 33.48 A
ATOM 329 CE LYS 412 72.077 64.958 4.618 1.00 33.48 A
ATOM 330 NZ LYS 412 72.086 65.378 3.177 1.00 33.48 A
ATOM 331 C LYS 412 67.646 66.763 7.081 1.00 33.48 A
ATOM 332 0 LYS 412 68.472 67.493 7.651 1.00 33.48 A
ATOM 333 N LEU 413 66.461 67.196 6.665 1.00 33.48 A
ATOM 334 CA LEU 413 66.058 68.585 6.780 1.00 33.48 A
ATOM 335 CB LEU 413 64.890 68.823 5.834 1.00 33.48 A
ATOM 336 CG LEU 413 65.133 68.267 4.430 1.00 33.48 A
ATOM 337 CDl LEU 413 63.867 68.369 3.590 1.00 33.48 A
ATOM 338 CD2 LEU 413 66.275 69.033 3.790 1.00 33.48 A
ATOM 339 C LEU 413 65.679 69.029 8.185 1.00 33.48 A
ATOM 340 0 LEU 413 65.263 68.222 9.002 1.00 33.48 A
ATOM 341 N SER 414 65.837 70.322 8.454 1.00 33.48 A
ATOM 342 CA SER 414 65.486 70.899 9.746 1.00 33.48 A
ATOM 343 CB SER 414 66.320 70.286 10.852 1.00 33.48 A
ATOM 344 OG SER 414 66.034 70.939 12.077 1.00 33.48 A
ATOM 345 C SER 414 65.646 72.416 9.805 1.00 33.48 A
ATOM 346 0 SER 414 66.673 72.926 10.256 1.00 33.48 A ATOM 347 N HIS 415 64.614 73.134 9.373 1.00 33.48 A
ATOM 348 CA HIS 415 64.646 74.590 9.372 1.00 33.48 A
ATOM 349 CB HIS 415 64.608 75.093 7.926 1.00 33.48 A
ATOM 350 CG HIS 415 64.842 76.564 7.787 1.00 33.48 A
ATOM 351 CD2 HIS 415 65.911 77.255 7.332 1.00 33.48 A
ATOM 352 NDl HIS 415 63.900 77.505 8.141 1.00 33.48 A
ATOM 353 CEl HIS 415 64.379 78.714 7.909 1.00 33.48 A
ATOM 354 NE2 HIS 415 65.599 78.589 7.417 1.00 33.48 A
ATOM 355 C HIS 415 63.478 75.156 10.189 1.00 33.48 A
ATOM 356 0 HIS 415 62.355 74.642 10.148 1.00 33.48 A
ATOM 357 N PRO 416 63.729 76.241 10.932 1.00 33.48 A
ATOM 358 CD PRO 416 64.934 77.081 10.871 1.00 33.48 A
ATOM 359 CA PRO 416 62.710 76.874 11.764 1.00 33.48 A
ATOM 360 CB PRO 416 63.383 78.164 12.220 1.00 33.48 A
ATOM 361 CG PRO 416 64.825 77.869 12.135 1.00 33.48 A
ATOM 362 C PRO 416 61.408 77.160 11.046 1.00 33.48 A
ATOM 363 0 PRO 416 60.396 77.408 11.692 1.00 33.48 A
ATOM 364 N LYS 417 61.424 77.138 9.717 1.00 33.48 A
ATOM 365 CA LYS 417 60.217 77.439 8.960 1.00 33.48 A
ATOM 366 CB LYS 417 60.447 78.660 8.081 1.00 33.48 A
ATOM 367 CG LYS 417 60.987 79.846 8.852 1.00 33.48 A
ATOM 368 CD LYS 417 60.087 80.189 10.014 1.00 33.48 A
ATOM 369 CE LYS 417 60.670 81.326 10.803 1.00 33.48 A
ATOM 370 NZ LYS 417 60.836 82.517 9.946 1.00 33.48 A
ATOM 371 C LYS 417 59.685 76.306 8.113 1.00 33.48 A
ATOM 372 0 LYS 417 59.080 76.533 7.079 1.00 33.48 A
ATOM 373 N LEU 418 59.913 75.082 8.556 1.00 33.48 A
ATOM 374 CA LEU 418 59.421 73.914 7.850 1.00 33.48 A
ATOM 375 CB LEU 418 60.557 73.269 7.055 1.00 33.48 A
ATOM 376 CG LEU 418 61.344 74.234 6.155 1.00 33.48 A
ATOM 377 CDl LEU 418 62.343 73.463 5.326 1.00 33.48 A
ATOM 378 CD2 LEU 418 60.397 74.976 5.241 1.00 33.48 A
ATOM 379 C LEU 418 58.941 72.986 8.952 1.00 33.48 A
ATOM 380 0 LEU 418 59.561 72.931 10.011 1.00 33.48 A
ATOM 381 N VAL 419 57.833 72.283 8.743 1.00 33.48 A
ATOM 382 CA VAL 419 57.355 71.374 9.778 1.00 33.48 A
ATOM 383 CB VAL 419 56.070 70.662 9.379 1.00 33.48 A
ATOM 384 CGI VAL 419 54.905 71.623 9.411 1.00 33.48 A
ATOM 385 CG2 VAL 419 56.235 70.075 7.999 1.00 33.48 A
ATOM 386 C VAL 419 58.405 70.311 10.042 1.00 33.48 A
ATOM 387 0 VAL 419 58.947 69.705 9.115 1.00 33.48 A
ATOM 388 N GLN 420 58.698 70.093 11.314 1.00 33.48 A
ATOM 389 CA GLN 420 59.681 69.103 11.703 1.00 33.48 A
ATOM 390 CB GLN 420 60.300 69.494 13.038 1.00 33.48 A ATOM 391 CG GLN 420 61.787 69.309 13.072 1.00 33.48 A
ATOM 392 CD GLN 420 62.173 67.874 12.788 1.00 33.48 A
ATOM 393 OEl GLN 420 62.984 67.591 11.887 1.00 33.48 A
ATOM 394 NE2 GLN 420 61.597 66.949 13.561 1.00 33.48 A
ATOM 395 C GLN 420 59.000 67.751 11.830 1.00 33.48 A
ATOM 396 0 GLN 420 57.862 67.663 12.285 1.00 33.48 A
ATOM 397 N LEU 421 59.670 66.695 11.391 1.00 33.48 A
ATOM 398 CA LEU 421 59.095 65.365 11.523 1.00 33.48 A
ATOM 399 CB LEU 421 59.353 64.515 10.287 1.00 33.48 A
ATOM 400 CG LEU 421 58.956 63.047 10.483 1.00 33.48 A
ATOM 401 CDl LEU 421 58.454 62.428 9.161 1.00 33.48 A
ATOM 402 CD2 LEU 421 60.159 62.280 11.028 1.00 33.48 A
ATOM 403 C LEU 421 59.792 64.755 12.714 1.00 33.48 A
ATOM 404 0 LEU 421 61.019 64.739 12.772 1.00 33.48 A
ATOM 405 N TYR 422 59.016 64.273 13.677 1.00 33.48 A
ATOM 406 CA TYR 422 59.593 63.672 14.869 1.00 33.48 A
ATOM 407 CB TYR 422 58.572 63.737 16.004 1.00 33.48 A
ATOM 408 CG TYR 422 58.351 65.123 16.567 1.00 33.48 A
ATOM 409 CDl TYR 422 57.107 65.499 17.061 1.00 33.48 A
ATOM 410 CEl TYR 422 56.897 66.758 17.628 1.00 33.48 A
ATOM 411 CD2 TYR 422 59.390 66.040 16.649 1.00 33.48 A
ATOM 412 CE2 TYR 422 59.194 67.309 17.215 1.00 33.48 A
ATOM 413 CZ TYR 422 57.941 67.661 17.704 1.00 33.48 A
ATOM 414 OH TYR 422 57.720 68.915 18.259 1.00 33.48 A
ATOM 415 C TYR 422 60.065 62.218 14.638 1.00 33.48 A
ATOM 416 0 TYR 422 61.185 61.873 15.004 1.00 33.48 A
ATOM 417 N GLY 423 59.216 61.383 14.029 1.00 33.48 A
ATOM 418 CA GLY 423 59.577 59.995 13.766 1.00 33.48 A
ATOM 419 C GLY 423 58.593 59.275 12.848 1.00 33.48 A
ATOM 420 0 GLY 423 57.726 59.920 12.250 1.00 33.48 A
ATOM 421 N VAL 424 58.718 57.950 12.723 1.00 33.48 A
ATOM 422 CA VAL 424 57.807 57.173 11.869 1.00 33.48 A
ATOM 423 CB VAL 424 58.491 56.725 10.573 1.00 33.48 A
ATOM 424 CGI VAL 424 57.605 57.086 9.381 1.00 33.48 A
ATOM 425 CG2 VAL 424 59.871 57.363 10.461 1.00 33.48 A
ATOM 426 C VAL 424 57.264 55.928 12.579 1.00 33.48 A
ATOM 427 0 VAL 424 57.610 55.674 13.738 1.00 33.48 A
ATOM 428 N CYS 425 56.435 55.147 11.880 1.00 33.48 A
ATOM 429 CA CYS 425 55.820 53.945 12.466 1.00 33.48 A
ATOM 430 CB CYS 425 54.313 54.140 12.581 1.00 33.48 A
ATOM 431 SG CYS 425 53.441 53.770 11.000 1.00 33.48 A
ATOM 432 C CYS 425 56.034 52.639 11.697 1.00 33.48 A
ATOM 433 0 CYS 425 56.795 52.576 10.732 1.00 33.48 A
ATOM 434 N LEU 426 55.314 51.606 12.139 1.00 33.48 A ATOM 435 CA LEU 426 55.355 50.272 11.532 1.00 33.48 A
ATOM 436 CB LEU 426 56.515 49.449 12.095 1.00 33.48 A
ATOM 437 CG LEU 426 57.882 49.857 11.560 1.00 33.48 A
ATOM 438 CDl LEU 426 58.900 48.711 11.797 1.00 33.48 A
ATOM 439 CD2 LEU 426 57.745 50.163 10.069 1.00 33.48 A
ATOM 440 C LEU 426 54.050 49.504 11.767 1.00 33.48 A
ATOM 441 O LEU 426 54.043 48.444 12.407 1.00 33.48 A
ATOM 442 N ILE 431 50.279 53.063 7.732 1.00 33.48 A
ATOM 443 CA ILE 431 51.323 53.647 8.583 1.00 33.48 A
ATOM 444 CB ILE 431 52.704 53.613 7.899 1.00 33.48 A
ATOM 445 CG2 ILE 431 53.302 52.225 8.050 1.00 33.48 A
ATOM 446 CGI ILE 431 52.574 54.002 6.411 1.00 33.48 A
ATOM 447 CDl ILE 431 51.676 55.226 6.103 1.00 33.48 A
ATOM 448 C ILE 431 51.084 55.087 9.001 1.00 33.48 A
ATOM 449 O ILE 431 50.059 55.700 8.679 1.00 33.48 A
ATOM 450 N CYS 432 52.072 55.639 9.686 1.00 33.48 A
ATOM 451 CA CYS 432 51.971 57.008 10.154 1.00 33.48 A
ATOM 452 CB CYS 432 51.092 57.064 11.410 1.00 33.48 A
ATOM 453 SG CYS 432 51.304 55.632 12.506 1.00 33.48 A
ATOM 454 C CYS 432 53.310 57.660 10.432 1.00 33.48 A
ATOM 455 O CYS 432 54.310 56.987 10.733 1.00 33.48 A
ATOM 456 N LEU 433 53.319 58.983 10.320 1.00 33.48 A
ATOM 457 CA LEU 433 54.529 59.752 10.566 1.00 33.48 A
ATOM 458 CB LEU 433 54.919 60.525 9.308 1.00 33.48 A
ATOM 459 CG LEU 433 54.740 59.695 8.031 1.00 33.48 A
ATOM 460 CDl LEU 433 53.301 59.840 7.560 1.00 33.48 A
ATOM 461 CD2 LEU 433 55.696 60.169 6.944 1.00 33.48 A
ATOM 462 C LEU 433 54.252 60.704 11.724 1.00 33.48 A
ATOM 463 O LEU 433 53.146 61.242 11.839 1.00 33.48 A
ATOM 464 N VAL 434 55.240 60.890 12.591 1.00 33.48 A
ATOM 465 CA VAL 434 55.076 61.769 13.736 1.00 33.48 A
ATOM 466 CB VAL 434 55.923 61.291 14.928 1.00 33.48 A
ATOM 467 CGI VAL 434 55.436 61.962 16.226 1.00 33.48 A
ATOM 468 CG2 VAL 434 55.863 59.782 15.030 1.00 33.48 A
ATOM 469 C VAL 434 55.537 63.169 13.362 1.00 33.48 A
ATOM 470 O VAL 434 56.664 63.340 12.869 1.00 33.48 A
ATOM 471 N PHE 435 54.680 64.164 13.601 1.00 33.48 A
ATOM 472 CA PHE 435 55.017 65.556 13.280 1.00 33.48 A
ATOM 473 CB PHE 435 54.233 66.021 12.054 1.00 33.48 A
ATOM 474 CG PHE 435 54.796 65.525 10.761 1.00 33.48 A
ATOM 475 CDl PHE 435 56.046 65.945 10.337 1.00 33.48 A
ATOM 476 CD2 PHE 435 54.088 64.624 9.984 1.00 33.48 A
ATOM 477 CEl PHE 435 56.584 65.473 9.158 1.00 33.48 A
ATOM 478 CE2 PHE 435 54.610 64.146 8.811 1.00 33.48 A ATOM 479 CZ PHE 435 55.865 64.568 8.390 1.00 33.48 A
ATOM 480 C PHE 435 54.787 66.541 14.414 1.00 33.48 A
ATOM 481 O PHE 435 54.241 66.185 15.451 1.00 33.48 A
ATOM 482 N GLU 436 55.208 67.785 14.217 1.00 33.48 A
ATOM 483 CA GLU 436 55.018 68.800 15.248 1.00 33.48 A
ATOM 484 CB GLU 436 56.162 69.822 15.210 1.00 33.48 A
ATOM 485 CG GLU 436 56.305 70.585 13.919 1.00 33.48 A
ATOM 486 CD GLU 436 57.287 71.736 14.048 1.00 33.48 A
ATOM 487 OEl GLU 436 57.068 72.589 14.928 1.00 33.48 A
ATOM 488 OE2 GLU 436 58.277 71.805 13.279 1.00 33.48 A
ATOM 489 C GLU 436 53.666 69.493 15.047 1.00 33.48 A
ATOM 490 O GLU 436 53.380 69.996 13.969 1.00 33.48 A
ATOM 491 N PHE 437 52.832 69.510 16.081 1.00 33.48 A
ATOM 492 CA PHE 437 51.506 70.131 15.985 1.00 33.48 A
ATOM 493 CB PHE 437 50.725 69.896 17.285 1.00 33.48 A
ATOM 494 CG PHE 437 49.256 70.181 17.173 1.00 33.48 A
ATOM 495 CDl PHE 437 48.693 71.249 17.843 1.00 33.48 A
ATOM 496 CD2 PHE 437 48.437 69.381 16.385 1.00 33.48 A
ATOM 497 CEl PHE 437 47.338 71.516 17.728 1.00 33.48 A
ATOM 498 CE2 PHE 437 47.086 69.642 16.265 1.00 33.48 A
ATOM 499 CZ PHE 437 46.536 70.710 16.935 1.00 33.48 A
ATOM 500 C PHE 437 51.561 71.632 15.669 1.00 33.48 A
ATOM 501 0 PHE 437 52.453 72.355 16.128 1.00 33.48 A
ATOM 502 N MET 438 50.609 72.098 14.872 1.00 33.48 A
ATOM 503 CA MET 438 50.570 73.504 14.498 1.00 33.48 A
ATOM 504 CB MET 438 50.803 73.659 12.986 1.00 33.48 A
ATOM 505 CG MET 438 52.149 73.143 12.503 1.00 33.48 A
ATOM 506 SD MET 438 53.546 73.997 13.267 1.00 33.48 A
ATOM 507 CE MET 438 53.636 75.483 12.243 1.00 33.48 A
ATOM 508 C MET 438 49.226 74.098 14.893 1.00 33.48 A
ATOM 509 0 MET 438 48.231 73.932 14.195 1.00 33.48 A
ATOM 510 N GLU 439 49.212 74.798 16.019 1.00 33.48 A
ATOM 511 CA GLU 439 47.997 75.401 16.554 1.00 33.48 A
ATOM 512 CB GLU 439 48.342 76.637 1 .400 1.00 33.48 A
ATOM 513 CG GLU 439 49.261 76.376 18.593 1.00 33.48 A
ATOM 514 CD GLU 439 49.401 77.595 19.496 1.00 33.48 A
ATOM 515 OEl GLU 439 48.580 77.756 20.425 1.00 33.48 A
ATOM 516 OE2 GLU 439 50.328 78.409 19.275 1.00 33.48 A
ATOM 517 C GLU 439 46.895 75.780 15.567 1.00 33.48 A
ATOM 518 0 GLU 439 45.778 75.314 15.698 1.00 33.48 A
ATOM 519 N HIS 440 47.191 76.589 14.563 1.00 33.48 A
ATOM 520 CA HIS 440 46.133 77.029 13.673 1.00 33.48 A
ATOM 521 CB HIS 440 46.314 78.524 13.449 1.00 33.48 A
ATOM 522 CG HIS 440 46.634 79.274 14.709 1.00 33.48 A ATOM 523 CD2 HIS 440 47.191 80.492 14.911 1.00 33.48 A
ATOM 524 NDl HIS 440 46.367 78.763 15.964 1.00 33.48 A
ATOM 525 CEl HIS 440 46.749 79.632 16.883 1.00 33.48 A
ATOM 526 NE2 HIS 440 47.252 80.691 16.271 1.00 33.48 A
ATOM 527 C HIS 440 45.869 76.325 12.345 1.00 33.48 A
ATOM 528 0 HIS 440 44.938 76.699 11.623 1.00 33.48 A
ATOM 529 N GLY 441 46.674 75.319 12.011 1.00 33.48 A
ATOM 530 CA GLY 441 46.482 74.577 10.766 1.00 33.48 A
ATOM 531 C GLY 441 46.796 75.264 9.441 1.00 33.48 A
ATOM 532 0 GLY 441 47.699 76.097 9.355 1.00 33.48 A
ATOM 533 N CYS 442 46.032 74.904 8.409 1.00 33.48 A
ATOM 534 CA CYS 442 46.182 75.444 7.051 1.00 33.48 A
ATOM 535 CB CYS 442 45.151 74.807 6.110 1.00 33.48 A
ATOM 536 SG CYS 442 45.351 73.014 5.790 1.00 33.48 A
ATOM 537 C CYS 442 46.064 76.962 6.903 1.00 33.48 A
ATOM 538 0 CYS 442 45.029 77.544 7.229 1.00 33.48 A
ATOM 539 N LEU 443 47.123 77.588 6.381 1.00 33.48 A
ATOM 540 CA LEU 443 47.144 79.026 6.158 1.00 33.48 A
ATOM 541 CB LEU 443 48.397 79.409 5.365 1.00 33.48 A
ATOM 542 CG LEU 443 48.598 80.870 4.921 1.00 33.48 A
ATOM 543 CDl LEU 443 48.527 81.828 6.114 1.00 33.48 A
ATOM 544 CD2 LEU 443 49.950 80.997 4.221 1.00 33.48 A
ATOM 545 C LEU 443 45.882 79.442 5.398 1.00 33.48 A
ATOM 546 0 LEU 443 45.203 80.407 5.761 1.00 33.48 A
ATOM 547 N SER 444 45.563 78.704 4.344 1.00 33.48 A
ATOM 548 CA SER 444 44.369 78.991 3.553 1.00 33.48 A
ATOM 549 CB SER 444 44.059 77.817 2.615 1.00 33.48 A
ATOM 550 OG SER 444 43.872 76.601 3.337 1.00 33.48 A
ATOM 551 C SER 444 43.163 79.263 4.458 1.00 33.48 A
ATOM 552 0 SER 444 42.483 80.268 4.290 1.00 33.48 A
ATOM 553 N ASP 445 42.911 78.371 5.415 1.00 33.48 A
ATOM 554 CA ASP 445 41.790 78.515 6.341 1.00 33.48 A
ATOM 555 CB ASP 445 41.670 77.286 7.240 1.00 33.48 A
ATOM 556 CG ASP 445 41.488 75.996 6.452 1.00 33.48 A
ATOM 557 ODl ASP 445 40.467 75.878 5.736 1.00 33.48 A
ATOM 558 OD2 ASP 445 42.365 75.101 6.542 1.00 33.48 A
ATOM 559 C ASP 445 41.987 79.727 7.218 1.00 33.48 A
ATOM 560 0 ASP 445 41.190 80.663 7.187 1.00 33.48 A
ATOM 561 N TYR 446 43.055 79.692 8.011 1.00 33.48 A
ATOM 562 CA TYR 446 43.392 80.785 8.919 1.00 33.48 A
ATOM 563 CB TYR 446 44.879 80.769 9.242 1.00 33.48 A
ATOM 564 CG TYR 446 45.291 81.725 10.337 1.00 33.48 A
ATOM 565 CDl TYR 446 45.119 81.396 11.679 1.00 33.48 A
ATOM 566 CEl TYR 446 45.488 82.271 12.679 1.00 33.48 A ATOM 567 CD2 TYR 446 45.846 82.959 10.030 1.00 33.48 A
ATOM 568 CE2 TYR 446 46.222 83.842 11.022 1.00 33.48 A
ATOM 569 CZ TYR 446 46.041 83.496 12.341 1.00 33.48 A
ATOM 570 OH TYR 446 46.413 84.386 13.321 1.00 33.48 A
ATOM 571 C TYR 446 43.057 82.084 8.231 1.00 33.48 A
ATOM 572 O TYR 446 42.217 82.852 8.690 1.00 33.48 A
ATOM 573 N LEU 447 43.717 82.319 7.111 1.00 33.48 A
ATOM 574 CA LEU 447 43.478 83.527 6.346 1.00 33.48 A
ATOM 575 CB LEU 447 44.217 83.431 5.009 1.00 33.48 A
ATOM 576 CG LEU 447 45.730 83.664 5.061 1.00 33.48 A
ATOM 577 CDl LEU 447 46.400 82.991 3.878 1.00 33.48 A
ATOM 578 CD2 LEU 447 46.011 85.157 5.056 1.00 33.48 A
ATOM 579 C LEU 447 41.978 83.765 6.116 1.00 33.48 A
ATOM 580 O LEU 447 41.440 84.817 6.447 1.00 33.48 A
ATOM 581 N ARG 448 41.299 82.777 5.564 1.00 33.48 A
ATOM 582 CA ARG 448 39.884 82.930 5.294 1.00 33.48 A
ATOM 583 CB ARG 448 39.335 81.659 4.637 1.00 33.48 A
ATOM 584 CG ARG 448 39.938 81.394 3.266 1.00 33.48 A
ATOM 585 CD ARG 448 39.315 80.189 2.606 1.00 33.48 A
ATOM 586 NE ARG 448 40.335 79.337 2.008 1.00 33.48 A
ATOM 587 CZ ARG 448 40.289 78.006 2.032 1.00 33.48 A
ATOM 588 NH1 ARG 448 39.270 77.378 2.624 1.00 33.48 A
ATOM 589 NH2 ARG 448 41.267 77.299 1.477 1.00 33.48 A
ATOM 590 C ARG 448 39.049 83.282 6.526 1.00 33.48 A
ATOM 591 0 ARG 448 38.180 84.166 6.467 1.00 33.48 A
ATOM 592 N THR 449 39.311 82.599 7.637 1.00 33.48 A
ATOM 593 CA THR 449 38.553 82.831 8.859 1.00 33.48 A
ATOM 594 CB THR 449 38.558 81.565 9.732 1.00 33.48 A
ATOM 595 OGl THR 449 39.852 81.373 10.309 1.00 33.48 A
ATOM 596 CG2 THR 449 38.239 80.355 8.880 1.00 33.48 A
ATOM 597 C THR 449 39.085 84.012 9.664 1.00 33.48 A
ATOM 598 0 THR 449 38.812 84.150 10.854 1.00 33.48 A
ATOM 599 N GLN 450 39.844 84.874 9.003 1.00 33.48 A
ATOM 600 CA GLN 450 40.420 86.032 9.667 1.00 33.48 A
ATOM 601 CB GLN 450 41.874 85.747 10.062 1.00 33.48 A
ATOM 602 CG GLN 450 42.059 84.878 11.283 1.00 33.48 A
ATOM 603 CD GLN 450 41.546 85.559 12.533 1.00 33.48 A
ATOM 604 OEl GLN 450 41.947 85.223 13.646 1.00 33.48 A
ATOM 605 NE2 GLN 450 40.643 86.523 12.357 1.00 33.48 A
ATOM 606 C GLN 450 40.384 87.229 8.747 1.00 33.48 A
ATOM 607 0 GLN 450 40.773 88.323 9.133 1.00 33.48 A
ATOM 608 N ARG 451 39.915 87.016 7.527 1.00 33.48 A
ATOM 609 CA ARG 451 39.863 88.090 6.550 1.00 33.48 A
ATOM 610 CB ARG 451 38.938 87.708 5.397 1.00 33.48 A ATOM 611 CG ARG 451 39.126 88.584 4.182 1.00 33, .48 A
ATOM 612 CD ARG 451 38.219 88.169 3.042 1.00 33, .48 A
ATOM 613 NE ARG 451 38.513 86.825 2.558 1.00 33, .48 A
ATOM 614 CZ ARG 451 37.836 86.217 1.583 1.00 33. .48 A
ATOM 615 NH1 ARG 451 36.822 86.836 0.987 1.00 33. .48 A
ATOM 616 NH2 ARG 451 38.173 84.987 1.199 1.00 33, .48 A
ATOM 617 C ARG 451 39.389 89.376 7.205 1.00 33. .48 A
ATOM 618 O ARG 451 38.527 89.348 8.078 1.00 33, .48 A
ATOM 619 N GLY 452 39.969 90.502 6.808 1.00 33. .48 A
ATOM 620 CA GLY 452 39.567 91.774 7.387 1.00 33, .48 A
ATOM 621 C GLY 452 40.370 92.212 8.602 1.00 33, .48 A
ATOM 622 O GLY 452 40.434 93.407 8.907 1.00 33, .48 A
ATOM 623 N LEU 453 40.987 91.258 9.296 1.00 33, .48 A
ATOM 624 CA LEU 453 41.776 91.570 10.493 1.00 33, .48 A
ATOM 625 CB LEU 453 41.469 90.591 11.628 1.00 33, .48 A
ATOM 626 CG LEU 453 40.029 90.146 11.842 1.00 33 .48 A
ATOM 627 CDl LEU 453 39.991 89.268 13.079 1.00 33, .48 A
ATOM 628 CD2 LEU 453 39.111 91.364 11.985 1.00 33, .48 A
ATOM 629 C LEU 453 43.270 91.509 10.266 1.00 33, .48 A
ATOM 630 O LEU 453 44.021 91.433 11.229 1.00 33, .48 A
ATOM 631 N PHE 454 43.704 91.527 9.014 1.00 33, .48 A
ATOM 632 CA PHE 454 45.126 91.439 8.721 1.00 33, .48 A
ATOM 633 CB PHE 454 45.381 90.367 7.662 1.00 33, .48 A
ATOM 634 CG PHE 454 45.332 88.959 8.174 1.00 33. .48 A
ATOM 635 CDl PHE 454 46.205 88.531 9.154 1.00 33, .48 A
ATOM 636 CD2 PHE 454 44.462 88.036 7.612 1.00 33, .48 A
ATOM 637 CEl PHE 454 46.221 87.209 9.561 1.00 33, .48 A
ATOM 638 CE2 PHE 454 44.470 86.705 8.016 1.00 33, .48 A
ATOM 639 CZ PHE 454 45.353 86.295 8.990 1.00 33. .48 A
ATOM 640 C PHE 454 45.749 92.738 8.233 1.00 33, .48 A
ATOM 641 O PHE 454 45.294 93.338 7.262 1.00 33, .48 A
ATOM 642 N ALA 455 46.799 93.175 8.909 1.00 33, .48 A
ATOM 643 CA ALA 455 47.491 94.370 8.464 1.00 33 .48 A
ATOM 644 CB ALA 455 48.329 94.951 9.583 1.00 33, .48 A
ATOM 645 C ALA 455 48.390 93.899 7.313 1.00 33, .48 A
ATOM 646 O ALA 455 48.770 92.723 7.236 1.00 33, .48 A
ATOM 647 N ALA 456 48.728 94.812 6.414 1.00 33, .48 A
ATOM 648 CA ALA 456 49.560 94.457 5.280 1.00 33, .48 A
ATOM 649 CB ALA 456 49.656 95.637 4.326 1.00 33, .48 A
ATOM 650 C ALA 456 50.951 94.012 5.716 1.00 33, .48 A
ATOM 651 O ALA 456 51.488 93.049 5.179 1.00 33. .48 A
ATOM 652 N GLU 457 51.526 94.712 6.690 1.00 33. .48 A
ATOM 653 CA GLU 457 52.862 94.383 7.170 1.00 33. .48 A
ATOM 654 CB GLU 457 53.313 95.373 8.250 1.00 33. .48 A ATOM 655 CG GLU 457 53.633 96.777 7.730 1.00 33.48 A
ATOM 656 CD GLU 457 52.390 97.616 7.388 1.00 33.48 A
ATOM 657 OEl GLU 457 51.613 97.957 8.315 1.00 33.48 A
ATOM 658 OE2 GLU 457 52.185 97.940 6.194 1.00 33.48 A
ATOM 659 C GLU 457 52.891 92.959 7.707 1.00 33.48 A
ATOM 660 0 GLU 457 53.926 92.288 7.685 1.00 33.48 A
ATOM 661 N THR 458 51.746 92.494 8.182 1.00 33.48 A
ATOM 662 CA THR 458 51.667 91.147 8.700 1.00 33.48 A
ATOM 663 CB THR 458 50.402 90.940 9.510 1.00 33.48 A
ATOM 664 OGl THR 458 50.514 91.649 10.746 1.00 33.48 A
ATOM 665 CG2 THR 458 50.182 89.457 9.769 1.00 33.48 A
ATOM 666 C THR 458 51.664 90.147 7.561 1.00 33.48 A
ATOM 667 0 THR 458 52.390 89.162 7.593 1.00 33.48 A
ATOM 668 N LEU 459 50.832 90.400 6.555 1.00 33.48 A
ATOM 669 CA LEU 459 50.735 89.518 5.400 1.00 33.48 A
ATOM 670 CB LEU 459 49.743 90.095 4.393 1.00 33.48 A
ATOM 671 CG LEU 459 48.374 90.462 4.970 1.00 33.48 A
ATOM 672 CDl LEU 459 47.491 91.048 3.882 1.00 33.48 A
ATOM 673 CD2 LEU 459 47.726 89.231 5.558 1.00 33.48 A
ATOM 674 C LEU 459 52.112 89.362 4.754 1.00 33.48 A
ATOM 675 0 LEU 459 52.504 88.263 4.379 1.00 33.48 A
ATOM 676 N LEU 460 52.848 90.462 4.641 1.00 33.48 A
ATOM 677 CA LEU 460 54.169 90.405 4.043 1.00 33.48 A
ATOM 678 CB LEU 460 54.849 91.768 4.068 1.00 33.48 A
ATOM 679 CG LEU 460 56.267 91.689 3.491 1.00 33.48 A
ATOM 680 CDl LEU 460 56.203 91.386 2.005 1.00 33.48 A
ATOM 681 CD2 LEU 460 56.999 92.990 3.726 1.00 33.48 A
ATOM 682 C LEU 460 55.015 89.436 4.829 1.00 33.48 A
ATOM 683 0 LEU 460 55.789 88.668 4.268 1.00 33.48 A
ATOM 684 N GLY 461 54.854 89.485 6.141 1.00 33.48 A
ATOM 685 CA GLY 461 55.615 88.627 7.018 1.00 33.48 A
ATOM 686 C GLY 461 55.345 87.165 6.784 1.00 33.48 A
ATOM 687 0 GLY 461 56.252 86.347 6.873 1.00 33.48 A
ATOM 688 N MET 462 54.103 86.813 6.501 1.00 33.48 A
ATOM 689 CA MET 462 53.821 85.414 6.259 1.00 33.48 A
ATOM 690 CB MET 462 52.330 85.214 6.001 1.00 33.48 A
ATOM 691 CG MET 462 51.460 85.821 7.100 1.00 33.48 A
ATOM 692 SD MET 462 49.694 85.423 7.061 1.00 33.48 A
ATOM 693 CE MET 462 49.486 84.822 8.712 1.00 33.48 A
ATOM 694 C MET 462 54.658 85.044 5.046 1.00 33.48 A
ATOM 695 0 MET 462 55.387 84.065 5.053 1.00 33.48 A
ATOM 696 N CYS 463 54.586 85.869 4.016 1.00 33.48 A
ATOM 697 CA CYS 463 55.351 85.628 2.813 1.00 33.48 A
ATOM 698 CB CYS 463 55.152 86.783 1.836 1.00 33.48 A ATOM 699 SG CYS 463 53.539 86.705 1.048 1.00 33.48 A
ATOM 700 C CYS 463 56.827 85.411 3.078 1.00 33.48 A
ATOM 701 O CYS 463 57.506 84.758 2.297 1.00 33.48 A
ATOM 702 N LEU 464 57.335 85.967 4.169 1.00 33.48 A
ATOM 703 CA LEU 464 58.739 85.783 4.507 1.00 33.48 A
ATOM 704 CB LEU 464 59.181 86.802 5.543 1.00 33.48 A
ATOM 705 CG LEU 464 59.767 88.094 4.999 1.00 33.48 A
ATOM 706 CDl LEU 464 59.898 89.088 6.134 1.00 33.48 A
ATOM 707 CD2 LEU 464 61.112 87.817 4.351 1.00 33.48 A
ATOM 708 C LEU 464 58.943 84.384 5.060 1.00 33.48 A
ATOM 709 O LEU 464 59.741 83.619 4.551 1.00 33.48 A
ATOM 710 N ASP 465 58.207 84.052 6.106 1.00 33.48 A
ATOM 711 CA ASP 465 58.319 82.742 6.704 1.00 33.48 A
ATOM 712 CB ASP 465 57.102 82.460 7.580 1.00 33.48 A
ATOM 713 CG ASP 465 57.058 83.325 8.834 1.00 33.48 A
ATOM 714 ODl ASP 465 55.950 83.469 9.397 1.00 33.48 A
ATOM 715 OD2 ASP 465 58.109 83.845 9.272 1.00 33.48 A
ATOM 716 C ASP 465 58.409 81.698 5.603 1.00 33.48 A
ATOM 717 O ASP 465 59.307 80.858 5.610 1.00 33.48 A
ATOM 718 N VAL 466 57.492 81.747 4.647 1.00 33.48 A
ATOM 719 CA VAL 466 57.508 80.773 3.571 1.00 33.48 A
ATOM 720 CB VAL 466 56.225 80.851 2.732 1.00 33.48 A
ATOM 721 CGI VAL 466 56.305 79.888 1.556 1.00 33.48 A
ATOM 722 CG2 VAL 466 55.034 80.519 3.595 1.00 33.48 A
ATOM 723 C VAL 466 58.713 80.914 2.651 1.00 33.48 A
ATOM 724 O VAL 466 59.164 79.938 2.079 1.00 33.48 A
ATOM 725 N CYS 467 59.246 82.121 2.510 1.00 33.48 A
ATOM 726 CA CYS 467 60.385 82.328 1.628 1.00 33.48 A
ATOM 727 CB CYS 467 60.526 83.807 1.267 1.00 33.48 A
ATOM 728 SG CYS 467 61.537 84.131 -0.215 1.00 33.48 A
ATOM 729 C CYS 467 61.665 81.829 2.272 1.00 33.48 A
ATOM 730 O CYS 467 62.537 81.301 1.592 1.00 33.48 A
ATOM 731 N GLU 468 61.785 82.000 3.584 1.00 33.48 A
ATOM 732 CA GLU 468 62.960 81.517 4.291 1.00 33.48 A
ATOM 733 CB GLU 468 62.953 81.971 5.746 1.00 33.48 A
ATOM 734 CG GLU 468 62.841 83.474 5.905 1.00 33.48 A
ATOM 735 CD GLU 468 63.059 83.936 7.336 1.00 33.48 A
ATOM 736 OEl GLU 468 62.803 85.133 7.623 1.00 33.48 A
ATOM 737 OE2 GLU 468 63.498 83.106 8.167 1.00 33.48 A
ATOM 738 C GLU 468 62.913 80.000 4.227 1.00 33.48 A
ATOM 739 O GLU 468 63.943 79.347 4.127 1.00 33.48 A
ATOM 740 N GLY 469 61.709 79.441 4.275 1.00 33.48 A
ATOM 741 CA GLY 469 61.580 78.002 4.194 1.00 33.48 A
ATOM 742 C GLY 469 61.982 77.511 2.820 1.00 33.48 A
Figure imgf000053_0001
ATOM 743 O GLY 469 62.764 76.575 2.670 1.00 33 .48 A
ATOM 744 N MET 470 61.430 78.155 1.804 1.00 33 .48 A
ATOM 745 CA MET 470 61.719 77.810 0.425 1.00 33, .48 A
ATOM 746 CB MET 470 60.830 78.628 -0.504 1.00 33, .48 A
ATOM 747 CG MET 470 59.416 78.137 -0.550 1.00 33, .48 A
ATOM 748 SD MET 470 59.389 76.366 -0.868 1.00 33, .48 A
ATOM 749 CE MET 470 59.112 75.746 0.786 1.00 33, .48 A
ATOM 750 C MET 470 63.186 78.036 0.O67 1.00 33, .48 A
ATOM 751 0 MET 470 63.776 77.264 -0.678 1.00 33, .48 A
ATOM 752 N ALA 471 63.769 79.104 0.595 1.00 33, .48 A
ATOM 753 CA ALA 471 65.160 79.411 0.325 1.00 33, .48 A
ATOM 754 CB ALA 471 65.533 80.721 0.984 1.00 33, .48 A
ATOM 755 C ALA 471 66.029 78.279 0.855 1.00 33, .48 A
ATOM 756 0 ALA 471 67.027 77.919 0.244 1.00 33 .48 A
ATOM 757 N TYR 472 65.642 77.714 1.993 1.00 33 .48 A
ATOM 758 CA TYR 472 66.384 76.619 2.599 1.00 33 .48 A
ATOM 759 CB TYR 472 65.833 76.307 3.984 1.00 33 .48 A
ATOM 760 CG TYR 472 66.611 75.237 4.706 1.00 33 .48 A
ATOM 761 CDl TYR 472 67.909 75.471 5.135 1.00 33 .48 A
ATOM 762 CEl TYR 472 68.637 74.497 5.749 1.00 33 .48 A
ATOM 763 CD2 TYR 472 66.065 73.981 4.923 1.00 33 .48 A
ATOM 764 CE2 TYR 472 66.789 72.997 5.537 1.00 33, .48 A
ATOM 765 CZ TYR 472 68.075 73.264 5.946 1.00 33, .48 A
ATOM 766 OH TYR 472 68.813 72.279 6.554 1.00 33, .48 A
ATOM 767 C TYR 472 66.251 75.388 1.714 1.00 33, .48 A
ATOM 768 0 TYR 472 67.240 74.893 1.164 1.00 33, .48 A
ATOM 769 N LEU 473 65.026 74.888 1.581 1.00 33, .48 A
ATOM 770 CA LEU 473 64.784 73.729 0.739 1.00 33, .48 A
ATOM 771 CB LEU 473 63.290 73.580 0.438 1.00 33, .48 A
ATOM 772 CG LEU 473 62.337 72.956 1.455 1.00 33, .48 A
ATOM 773 CDl LEU 473 60.947 72.868 0.855 1.00 33, .48 A
ATOM 774 CD2 LEU 473 62.825 71.569 1.827 1.00 33 .48 A
ATOM 775 C LEU 473 65.527 73.926 -0.574 1.00 33 .48 A
ATOM 776 0 LEU 473 66.147 73.008 -1.099 1.00 33 .48 A
ATOM 777 N GLU 474 65.465 75.145 -1.093 1.00 33 .48 A
ATOM 778 CA GLU 474 66.095 75.467 -2.360 1.00 33 .48 A
ATOM 779 CB GLU 474 66.107 76.977 -2.6O3 1.00 33 .48 A
ATOM 780 CG GLU 474 66.743 77.333 -3.925 1.00 33 .48 A
ATOM 781 CD GLU 474 66.861 78.818 -4.170 1.00 33 .48 A
ATOM 782 OEl GLU 474 67.452 79.534 -3.326 1.00 33 .48 A
ATOM 783 OE2 GLU 474 66.368 79.264 -5.228 1.00 33 .48 A
ATOM 784 C GLU 474 67.504 74.971 -2.429 1.00 33, .48 A
ATOM 785 0 GLU 474 67.911 74.354 -3.411 1.00 33, .48 A
ATOM 786 N GLU 475 68.241 75.248 -1.365 1.00 33, .48 A ATOM 787 CA GLU 475 69.642 74.890 -1.274 1.00 33..48 A
ATOM 788 CB GLU 475 70.297 75.758 -0.223 1.00 33. .48 A
ATOM 789 CG GLU 475 71.784 75.645 -0.221 1.00 33. .48 A
ATOM 790 CD GLU 475 72.408 76.635 0.715 1.00 33, .48 A
ATOM 791 OEl GLU 475 71.876 76.771 1.840 1.00 33, .48 A
ATOM 792 OE2 GLU 475 73.418 77.265 0.326 1.00 33, .48 A
ATOM 793 C GLU 475 69.936 73.419 -0.995 1.00 33, .48 A
ATOM 794 O GLU 475 71.006 72.919 -1.348 1.00 33, .48 A
ATOM 795 N ALA 476 69.000 72.732 -0.347 1.00 33, .48 A
ATOM 796 CA ALA 476 69.169 71.314 -0.059 1.00 33, .48 A
ATOM 797 CB ALA 476 68.366 70.913 1.164 1.00 33, .48 A
ATOM 798 C ALA 476 68.630 70.616 -1.281 1.00 33 .48 A
ATOM 799 O ALA 476 68.435 69.409 -1.292 1.00 33 .48 A
ATOM 800 N CYS 477 68.395 71.405 -2.315 1.00 33 .48 A
ATOM 801 CA CYS 477 67.859 70.900 -3.561 1.00 33 .48 A
ATOM 802 CB CYS 477 68.962 70.284 -4.395 1.00 33, .48 A
ATOM 803 SG CYS 477 70.040 71.545 -4.995 1.00 33, .48 A
ATOM 804 C CYS 477 66.708 69.924 -3.417 1.00 33, .48 A
ATOM 805 O CYS 477 66.648 68.910 -4.115 1.00 33, .48 A
ATOM 806 N VAL 478 65.792 70.240 -2.507 1.00 33, .48 A
ATOM 807 CA VAL 478 64.620 69.414 -2.316 1.00 33, .48 A
ATOM 808 CB VAL 478 64.401 69.064 -0.852 1.00 33, .48 A
ATOM 809 CGI VAL 478 63.067 68.347 -0.695 1.00 33, .48 A
ATOM 810 CG2 VAL 478 65.538 68.179 -0.360 1.00 33, .48 A
ATOM 811 C VAL 478 63.439 70.215 -2.819 1.00 33, .48 A
ATOM 812 O VAL 478 63.011 71.165 -2.181 1.00 33, .48 A
ATOM 813 N ILE 479 62.928 69.829 -3.981 1.00 33 .48 A
ATOM 814 CA ILE 479 61.805 70.516 -4.601 1.00 33 .48 A
ATOM 815 CB ILE 479 61.635 70.096 -6.072 1.00 33 .48 A
ATOM 816 CG2 ILE 479 60.374 70.706 -6.637 1.00 33 .48 A
ATOM 817 CGI ILE 479 62.865 70.491 -6.884 1.00 33, .48 A
ATOM 818 CDl ILE 479 62.875 69.891 -8.258 1.00 33, .48 A
ATOM 819 C ILE 479 60.516 70.175 -3.904 1.00 33, .48 A
ATOM 820 O ILE 479 60.271 69.015 -3.600 1.00 33, .48 A
ATOM 821 N HIS 480 59.695 71.186 -3.654 1.00 33, .48 A
ATOM 822 CA HIS 480 58.393 70.992 -3.024 1.00 33, .48 A
ATOM 823 CB HIS 480 58.100 72.137 -2.065 1.00 33, .48 A
ATOM 824 CG HIS 480 56.825 71.980 -1.298 1.00 33, .48 A
ATOM 825 CD2 HIS 480 56.563 72.092 0.027 1.00 33, .48 A
ATOM 826 NDl HIS 480 55.624 71.687 -1.903 1.00 33, .48 A
ATOM 827 CEl HIS 480 54.677 71.623 -0.984 1.00 33, .48 A
ATOM 828 NE2 HIS 480 55.221 71.866 0.195 1.00 33, .48 A
ATOM 829 C HIS 480 57.478 71.089 -4.218 1.00 33, .48 A
ATOM 830 O HIS 480 57.079 72.178 -4.596 1.00 33 .48 A ATOM 831 N ARG 481 57.156 69.956 -4.826 1.00 33.48 A
ATOM 832 CA ARG 481 56.331 69.940 -6.031 1.00 33.48 A
ATOM 833 CB ARG 481 56.266 68.508 -6.562 1.00 33.48 A
ATOM 834 CG ARG 481 57.603 68.000 -7.047 1.00 33.48 A
ATOM 835 CD ARG 481 57.762 66.492 -6.864 1.00 33.48 A
ATOM 836 NE ARG 481 58.080 65.806 -8.119 1.00 33.48 A
ATOM 837 CZ ARG 481 57.167 65.348 -8.979 1.00 33.48 A
ATOM 838 NH1 ARG 481 55.863 65.493 -8.733 1.00 33.48 A
ATOM 839 NH2 ARG 481 57.560 64.739 -10.094 1.00 33.48 A
ATOM 840 C ARG 481 54.920 70.528 -5.949 1.00 33.48 A
ATOM 841 0 ARG 481 54.182 70.513 -6.930 1.00 33.48 A
ATOM 842 N ASP 482 54.543 71.073 -4.805 1.00 33.48 A
ATOM 843 CA ASP 482 53.197 71.606 -4.695 1.00 33.48 A
ATOM 844 CB ASP 482 52.239 70.451 -4.450 1.00 33.48 A
ATOM 845 CG ASP 482 50.817 70.905 -4.355 1.00 33.48 A
ATOM 846 ODl ASP 482 49.971 70.093 -3.933 1.00 33.48 A
ATOM 847 OD2 ASP 482 50.541 72.074 -4.706 1.00 33.48 A
ATOM 848 C ASP 482 52.969 72.674 -3.624 1.00 33.48 A
ATOM 849 0 ASP 482 52.082 72.529 -2.793 1.00 33.48 A
ATOM 850 N LEU 483 53.744 73.750 -3.645 1.00 33.48 A
ATOM 851 CA LEU 483 53.570 74.791 -2.644 1.00 33.48 A
ATOM 852 CB LEU 483 54.652 75.857 -2.779 1.00 33.48 A
ATOM 853 CG LEU 483 54.694 76.933 -1.699 1.00 33.48 A
ATOM 854 CDl LEU 483 54.727 76.291 -0.342 1.00 33.48 A
ATOM 855 CD2 LEU 483 55.929 77.780 -1.887 1.00 33.48 A
ATOM 856 C LEU 483 52.211 75.432 -2.815 1.00 33.48 A
ATOM 857 0 LEU 483 51.730 75.577 -3.931 1.00 33.48 A
ATOM 858 N ALA 484 51.600 75.808 -1.696 1.00 33.48 A
ATOM 859 CA ALA 484 50.283 76.436 -1.688 1.00 33.48 A
ATOM 860 CB ALA 484 49.245 75.478 -2.256 1.00 33.48 A
ATOM 861 C ALA 484 49.918 76.817 -0.258 1.00 33.48 A
ATOM 862 0 ALA 484 50.458 76.259 0.695 1.00 33.48 A
ATOM 863 N ALA 485 49.005 77.772 -0.107 1.00 33.48 A
ATOM 864 CA ALA 485 48.582 78.204 1.218 1.00 33.48 A
ATOM 865 CB ALA 485 47.535 79.292 1.107 1.00 33.48 A
ATOM 866 C ALA 485 48.003 77.007 1.938 1.00 33.48 A
ATOM 867 0 ALA 485 48.062 76.913 3.161 1.00 33.48 A
ATOM 868 N ARG 486 47.444 76.083 1.170 1.00 33.48 A
ATOM 869 CA ARG 486 46.853 74.892 1.751 1.00 33.48 A
ATOM 870 CB ARG 486 46.020 74.148 0.695 1.00 33.48 A
ATOM 871 CG ARG 486 46.794 73.694 -0.548 1.00 33.48 A
ATOM 872 CD ARG 486 45.858 73.238 -1.689 1.00 33.48 A
ATOM 873 NE ARG 486 46.556 73.157 -2.978 1.00 33.48 A
ATOM 874 CZ ARG 486 47.460 72.227 -3.297 1.00 33.48 A ATOM 875 NH1 ARG 486 47.789 71.273 -2.428 1.00 33.48 A
ATOM 876 NH2 ARG 486 48.053 72.259 -4.487 1.00 33.48 A
ATOM 877 C ARG 486 47.892 73.953 2.371 1.00 33.48 A
ATOM 878 O ARG 486 47.537 73.088 3.164 1.00 33.48 A
ATOM 879 N ASN 487 49.165 74.121 2.018 1.00 33.48 A
ATOM 880 CA ASN 487 50.239 73.280 2.557 1.00 33.48 A
ATOM 881 CB ASN 487 51.236 72.878 1.469 1.00 33.48 A
ATOM 882 CG ASN 487 50.711 71.790 0.581 1.00 33.48 A
ATOM 883 ODl ASN 487 50.238 70.756 1.065 1.00 33.48 A
ATOM 884 ND2 ASN 487 50.790 72.001 -0.729 1.00 33.48 A
ATOM 885 C ASN 487 51.015 74.014 3.617 1.00 33.48 A
ATOM 886 O ASN 487 52.062 73.561 4.053 1.00 33.48 A
ATOM 887 N CYS 488 50.524 75.166 4.024 1.00 33.48 A
ATOM 888 CA CYS 488 51.247 75.920 5.018 1.00 33.48 A
ATOM 889 CB CYS 488 51.463 77.349 4.510 1.00 33.48 A
ATOM 890 SG CYS 488 52.377 77.401 2.930 1.00 33.48 A
ATOM 891 C CYS 488 50.495 75.894 6.335 1.00 33.48 A
ATOM 892 O CYS 488 49.265 75.997 6.366 1.00 33.48 A
ATOM 893 N LEU 489 51.241 75.747 7.423 1.00 33.48 A
ATOM 894 CA LEU 489 50.645 75.686 8.743 1.00 33.48 A
ATOM 895 CB LEU 489 51.096 74.402 9.416 1.00 33.48 A
ATOM 896 CG LEU 489 50.717 73.202 8.551 1.00 33.48 A
ATOM 897 CDl LEU 489 51.428 71.975 9.060 1.00 33.48 A
ATOM 898 CD2 LEU 489 49.203 73.018 8.552 1.00 33.48 A
ATOM 899 C LEU 489 50.968 76.884 9.626 1.00 33.48 A
ATOM 900 O LEU 489 51.996 77.541 9.454 1.00 33.48 A
ATOM 901 N VAL 490 50.075 77.165 10.571 1.00 33.48 A
ATOM 902 CA VAL 490 50.254 78.275 11.491 1.00 33.48 A
ATOM 903 CB VAL 490 49.016 79.177 11.503 1.00 33.48 A
ATOM 904 CGl VAL 490 49.266 80.379 12.377 1.00 33.48 A
ATOM 905 CG2 VAL 490 48.678 79.617 10.102 1.00 33.48 A
ATOM 906 C VAL 490 50.501 77.765 12.912 1.00 33.48 A
ATOM 907 0 VAL 490 49.619 77.191 13.547 1.00 33.48 A
ATOM 908 N GLY 491 51.707 77.977 13.416 1.00 33.48 A
ATOM 909 CA GLY 491 52.015 77.524 14.758 1.00 33.48 A
ATOM 910 C GLY 491 52.156 78.663 15.747 1.00 33.48 A
ATOM 911 0 GLY 491 51.569 79.733 15.565 1.00 33.48 A
ATOM 912 N GLU 492 52.943 78.434 16.795 1.00 33.48 A
ATOM 913 CA GLU 492 53.164 79.437 17.835 1.00 33.48 A
ATOM 914 CB GLU 492 54.323 78.987 18.736 1.00 33.48 A
ATOM 915 CG GLU 492 54.734 79.990 19.819 1.00 33.48 A
ATOM 916 CD GLU 492 55.916 79.495 20.665 1.00 33.48 A
ATOM 917 OEl GLU 492 56.385 80.261 21.552 1.00 33.48 A
ATOM 918 OE2 GLU 492 56.374 78.340 20.441 1.00 33.48 A ATOM 919 C GLU 492 53.436 80.857 17.295 1.00 33.48 A
ATOM 920 O GLU 492 54.420 81.097 16.592 1.00 33.48 A
ATOM 921 N ASN 493 52.541 81.786 17.625 1.00 33.48 A
ATOM 922 CA ASN 493 52.692 83.170 17.204 1.00 33.48 A
ATOM 923 CB ASN 493 54.068 83.673 17.631 1.00 33.48 A
ATOM 924 CG ASN 493 54.206 83.771 19.141 1.00 33.48 A
ATOM 925 ODl ASN 493 55.310 83.636 19.692 1.00 33.48 A
ATOM 926 ND2 ASN 493 53.080 84.025 19.824 1.00 33.48 A
ATOM 927 C ASN 493 52.487 83.440 15.711 1.00 33.48 A
ATOM 928 O ASN 493 53.252 84.187 15.085 1.00 33.48 A
ATOM 929 N GLN 494 51.454 82.830 15.141 1.00 33.48 A
ATOM 930 CA GLN 494 51.134 83.045 13.744 1.00 33.48 A
ATOM 931 CB GLN 494 50.621 84.460 13.542 1.00 33.48 A
ATOM 932 CG GLN 494 49.159 84.549 13.182 1.00 33.48 A
ATOM 933 CD GLN 494 48.785 85.945 12.728 1.00 33.48 A
ATOM 934 OEl GLN 494 47.688 86.175 12.207 1.00 33.48 A
ATOM 935 NE2 GLN 494 49.699 86.891 12.923 1.00 33.48 A
ATOM 936 C GLN 494 52.303 82.842 12.823 1.00 33.48 A
ATOM 937 0 GLN 494 52.351 83.445 11.764 1.00 33.48 A
ATOM 938 N VAL 495 53.255 82.012 13.225 1.00 33.48 A
ATOM 939 CA VAL 495 54.414 81.741 12.388 1.00 33.48 A
ATOM 940 CB VAL 495 55.532 81.073 13.172 1.00 33.48 A
ATOM 941 CGI VAL 495 56.687 80.755 12.245 1.00 33.48 A
ATOM 942 CG2 VAL 495 55.990 81.982 14.299 1.00 33.48 A
ATOM 943 C VAL 495 53.992 80.779 11.313 1.00 33.48 A
ATOM 944 O VAL 495 53.334 79.783 11.593 1.00 33.48 A
ATOM 945 N ILE 496 54.363 81.060 10.078 1.00 33.48 A
ATOM 946 CA ILE 496 53.984 80.158 9.006 1.00 33.48 A
ATOM 947 CB ILE 496 53.641 80.932 7.693 1.00 33.48 A
ATOM 948 CG2 ILE 496 53.326 79.969 6.578 1.00 33.48 A
ATOM 949 CGI ILE 496 52.409 81.805 7.898 1.00 33.48 A
ATOM 950 CDl ILE 496 52.669 83.047 8.714 1.00 33.48 A
ATOM 951 C ILE 496 55.126 79.184 8.743 1.00 33.48 A
ATOM 952 O ILE 496 56.296 79.556 8.812 1.00 33.48 A
ATOM 953 N LYS 497 54.777 77.929 8.478 1.00 33.48 A
ATOM 954 CA LYS 497 55.761 76.902 8.165 1.00 33.48 A
ATOM 955 CB LYS 497 56.011 75.981 9.356 1.00 33.48 A
ATOM 956 CG LYS 497 56.913 76.582 10.427 1.00 33.48 A
ATOM 957 CD LYS 497 57.080 75.617 11.605 1.00 33.48 A
ATOM 958 CE LYS 497 57.840 76.255 12.758 1.00 33.48 A
ATOM 959 NZ LYS 497 57.779 75.409 13.981 1.00 33.48 A
ATOM 960 C LYS 497 55.263 76.093 6.986 1.00 33.48 A
ATOM 961 O LYS 497 54.063 75.950 6.785 1.00 33.48 A
ATOM 962 N VAL 498 56.198 75.567 6.208 1.00 33.48 A ATOM 963 CA VAL 498 55.877 74.789 5.023 1.00 33.48 A
ATOM 964 CB VAL 498 56.896 75.078 3.888 1.00 33.48 A
ATOM 965 CGI VAL 498 56.568 74.231 2.650 1.00 33.48 A
ATOM 966 CG2 VAL 498 56.882 76.567 3.543 1.00 33.48 A
ATOM 967 C VAL 498 55.900 73.309 5.332 1.00 33.48 A
ATOM 968 O VAL 498 56.619 72.875 6.212 1.00 33.48 A
ATOM 969 N SER 499 55.116 72.537 4.596 1.00 33.48 A
ATOM 970 CA SER 499 55.055 71.100 4.799 1.00 33.48 A
ATOM 971 CB SER 499 54.035 70.772 5.877 1.00 33.48 A
ATOM 972 OG SER 499 52.719 70.958 5.390 1.00 33.48 A
ATOM 973 C SER 499 54.616 70.459 3.495 1.00 33.48 A
ATOM 974 0 SER 499 54.016 71.130 2.658 1.00 33.48 A
ATOM 975 N ASP 500 54.907 69.168 3.339 1.00 33.48 A
ATOM 976 CA ASP 500 54.561 68.377 2.146 1.00 33.48 A
ATOM 977 CB ASP 500 53.278 68.876 1.482 1.00 33.48 A
ATOM 978 CG ASP 500 52.047 68.502 2.265 1.00 33.48 A
ATOM 979 ODl ASP 500 52.128 68.566 3.512 1.00 33.48 A
ATOM 980 OD2 ASP 500 51.003 68.156 1.648 1.00 33.48 A
ATOM 981 C ASP 500 55.647 68.300 1.084 1.00 33.48 A
ATOM 982 0 ASP 500 55.572 67.457 0.187 1.00 33.48 A
ATOM 983 N PHE 501 56.649 69.168 1.162 1.00 33.48 A
ATOM 984 CA PHE 501 57.701 69.102 0.163 1.00 33.48 A
ATOM 985 CB PHE 501 58.943 69.891 0.610 1.00 33.48 A
ATOM 986 CG PHE 501 59.250 69.778 2.073 1.00 33.48 A
ATOM 987 CDl PHE 501 60.166 68.849 2.536 1.00 33.48 A
ATOM 988 CD2 PHE 501 58.630 70.616 2.985 1.00 33.48 A
ATOM 989 CEl PHE 501 60.459 68.762 3.878 1.00 33.48 A
ATOM 990 CE2 PHE 501 58.920 70.534 4.332 1.00 33.48 A
ATOM 991 CZ PHE 501 59.835 69.609 4.780 1.00 33.48 A
ATOM 992 C PHE 501 58.015 67.629 -0.044 1.00 33.48 A
ATOM 993 0 PHE 501 58.416 66.919 0.888 1.00 33.48 A
ATOM 994 N GLY 502 57.775 67.171 -1.269 1.00 33.48 A
ATOM 995 CA GLY 502 58.006 65.781 -1.606 1.00 33.48 A
ATOM 996 C GLY 502 56.704 65.013 -1.777 1.00 33.48 A
ATOM 997 0 GLY 502 56.192 64.901 -2.886 1.00 33.48 A
ATOM 998 N MET 503 56.162 64.506 -0.670 1.00 33.48 A
ATOM 999 CA MET 503 54.940 63.707 -0.680 1.00 33.48 A
ATOM 1000 CB MET 503 54.276 63.736 0.696 1.00 33.48 A
ATOM 1001 CG MET 503 55.188 63.366 1.858 1.00 33.48 A
ATOM 1002 SD MET 503 54.250 63.279 3.438 1.00 33.48 A
ATOM 1003 CE MET 503 53.896 65.122 3.792 1.00 33.48 A
ATOM 1004 C MET 503 53.943 64.155 -1.738 1.00 33.48 A
ATOM 1005 0 MET 503 52.967 64.839 -1.435 1.00 33.48 A
ATOM 1006 N THR 504 54.199 63.747 -2.978 1.00 33.48 A ATOM 1007 CA THR 504 53.367 64.075 -4.142 1.00 33.48 A
ATOM 1008 CB THR 504 53.309 65.606 -4.447 1.00 33.48 A
ATOM 1009 OGl THR 504 54.014 66.342 -3.428 1.00 33.48 A
ATOM 1010 CG2 THR 504 51.856 66.075 -4.527 1.00 33.48 A
ATOM 1011 C THR 504 54.059 63.411 -5.319 1.00 33.48 A
ATOM 1012 0 THR 504 53.416 63.017 -6.297 1.00 33.48 A
ATOM 1013 N ARG 505 55.384 63.317 -5.203 1.00 33.48 A
ATOM 1014 CA ARG 505 56.244 62.701 -6.202 1.00 33.48 A
ATOM 1015 CB ARG 505 57.692 62.673 -5.673 1.00 33.48 A
ATOM 1016 CG ARG 505 58.706 61.924 -6.550 1.00 33.48 A
ATOM 1017 CD ARG 505 60.151 62.258 -6.166 1.00 33.48 A
ATOM 1018 NE ARG 505 60.531 61.826 -4.815 1.00 33.48 A
ATOM 1019 CZ ARG 505 60.972 60.603 -4.496 1.00 33.48 A
ATOM 1020 NHl ARG 505 61.095 59.658 -5.430 1.00 33.48 A
ATOM 1021 NH2 ARG 505 61.310 60.323 -3.234 1.00 33.48 A
ATOM 1022 C ARG 505 55.761 61.278 -6.513 1.00 33.48 A
ATOM 1023 0 ARG 505 55.083 60.637 -5.699 1.00 33.48 A
ATOM 1024 N PHE 520 44.614 67.698 -11.043 1.00 33.48 A
ATOM 1025 CA PHE 520 45.872 68.437 -11.070 1.00 33.48 A
ATOM 1026 CB PHE 520 46.469 68.404 -12.482 1.00 33.48 A
ATOM 1027 CG PHE 520 47.924 68.803 -12.547 1.00 33.48 A
ATOM 1028 CDl PHE 520 48.297 70.047 -13.022 1.00 33.48 A
ATOM 1029 CD2 PHE 520 48.926 67.904 -12.172 1.00 33.48 A
ATOM 1030 CEl PHE 520 49.643 70.389 -13.131 1.00 33.48 A
ATOM 1031 CE2 PHE 520 50.279 68.243 -12.279 1.00 33.48 A
ATOM 1032 CZ PHE 520 50.635 69.482 -12.759 1.00 33.48 A
ATOM 1033 C PHE 520 45.669 69.884 -10.621 1.00 33.48 A
ATOM 1034 0 PHE 520 44.757 70.575 -11.066 1.00 33.48 A
ATOM 1035 N PRO 521 46.505 70.355 -9.704 1.00 33.48 A
ATOM 1036 CD PRO 521 47.353 69.626 -8.746 1.00 33.48 A
ATOM 1037 CA PRO 521 46.293 71.741 -9.295 1.00 33.48 A
ATOM 1038 CB PRO 521 46.761 71.736 -7.843 1.00 33.48 A
ATOM 1039 CG PRO 521 47.873 70.728 -7.854 1.00 33.48 A
ATOM 1040 C PRO 521 47.098 72.673 -10.198 1.00 33.48 A
ATOM 1041 0 PRO 521 48.082 73.274 -9.777 1.00 33.48 A
ATOM 1042 N VAL 522 46.663 72.780 -11.448 1.00 33.48 A
ATOM 1043 CA VAL 522 47.344 73.607 -12.429 1.00 33.48 A
ATOM 1044 CB VAL 522 46.613 73.598 -13.771 1.00 33.48 A
ATOM 1045 CGl VAL 522 46.286 72.180 -14.182 1.00 33.48 A
ATOM 1046 CG2 VAL 522 45.353 74.410 -13.664 1.00 33.48 A
ATOM 1047 C VAL 522 47.458 75.048 -11.984 1.00 33.48 A
ATOM 1048 0 VAL 522 48.379 75.753 -12.391 1.00 33.48 A
ATOM 1049 N LYS 523 46.532 75.485 -11.139 1.00 33.48 A
ATOM 1050 CA LYS 523 46.539 76.868 -10.674 1.00 33.48 A ATOM 1051 CB LYS 523 45.370 77.118 -9.726 1.00 33.48 A
ATOM 1052 CG LYS 523 44.016 76.897 -10.399 1.00 33.48 A
ATOM 1053 CD LYS 523 42.849 77.289 -9.510 1.00 33.48 A
ATOM 1054 CE LYS 523 41.536 77.172 -10.261 1.00 33.48 A
ATOM 1055 NZ LYS 523 40.416 77.680 -9.419 1.00 33.48 A
ATOM 1056 C LYS 523 47.842 77.300 -10.032 1.00 33.48 A
ATOM 1057 0 LYS 523 48.260 78.439 -10.201 1.00 33.48 A
ATOM 1058 N TRP 524 48.485 76.397 -9.302 1.00 33.48 A
ATOM 1059 CA TRP 524 49.761 76.703 -8.658 1.00 33.48 A
ATOM 1060 CB TRP 524 49.868 76.007 -7.307 1.00 33.48 A
ATOM 1061 CG TRP 524 49.060 76.634 -6.279 1.00 33.48 A
ATOM 1062 CD2 TRP 524 47.705 76.329 -5.960 1.00 33.48 A
ATOM 1063 CE2 TRP 524 47.301 77.235 -4.962 1.00 33.48 A
ATOM 1064 CE3 TRP 524 46.791 75.383 -6.423 1.00 33.48 A
ATOM 1065 CDl TRP 524 49.420 77.670 -5.490 1.00 33.48 A
ATOM 1066 NEl TRP 524 48.370 78.044 -4.692 1.00 33.48 A
ATOM 1067 CZ2 TRP 524 46.019 77.225 -4.416 1.00 33.48 A
ATOM 1068 CZ3 TRP 524 45.517 75.375 -5.881 1.00 33.48 A
ATOM 1069 CH2 TRP 524 45.144 76.289 -4.890 1.00 33.48 A
ATOM 1070 C TRP 524 50.926 76.240 -9.501 1.00 33.48 A
ATOM 1071 O TRP 524 52.066 76.525 -9.176 1.00 33.48 A
ATOM 1072 N ALA 525 50.638 75.533 -10.584 1.00 33.48 A
ATOM 1073 CA ALA 525 51.681 74.994 -11.432 1.00 33.48 A
ATOM 1074 CB ALA 525 51.166 73.779 -12.134 1.00 33.48 A
ATOM 1075 C ALA 525 52.258 75.951 -12.448 1.00 33.48 A
ATOM 1076 O ALA 525 51.530 76.712 -13.080 1.00 33.48 A
ATOM 1077 N SER 526 53.575 75.905 -12.612 1.00 33.48 A
ATOM 1078 CA SER 526 54.245 76.759 -13.580 1.00 33.48 A
ATOM 1079 CB SER 526 55.759 76.665 -13.438 1.00 33.48 A
ATOM 1080 OG SER 526 56.227 75.452 -13.986 1.00 33.48 A
ATOM 1081 C SER 526 53.862 76.204 -14.922 1.00 33.48 A
ATOM 1082 O SER 526 53.562 75.025 -15.044 1.00 33.48 A
ATOM 1083 N PRO 527 53.878 77.045 -15.955 1.00 33.48 A
ATOM 1084 CD PRO 527 54.197 78.476 -15.956 1.00 33.48 A
ATOM 1085 CA PRO 527 53.519 76.596 -17.298 1.00 33.48 A
ATOM 1086 CB PRO 527 53.694 77.857 -18.146 1.00 33.48 A
ATOM 1087 CG PRO 527 54.655 78.675 -17.371 1.00 33.48 A
ATOM 1088 C PRO 527 54.312 75.408 -17.818 1.00 33.48 A
ATOM 1089 0 PRO 527 53.768 74.577 -18.542 1.00 33.48 A
ATOM 1090 N GLU 528 55.584 75.305 -17.448 1.00 33.48 A
ATOM 1091 CA GLU 528 56.382 74.177 -17.920 1.00 33.48 A
ATOM 1092 CB GLU 528 57.880 74.493 -17.948 1.00 33.48 A
ATOM 1093 CG GLU 528 58.591 74.467 -16.611 1.00 33.48 A
ATOM 1094 CD GLU 528 58.372 75.729 -15.808 1.00 33.48 A ATOM 1095 OEl GLU 528 58.003 76.766 -16.,389 1.00 33.48 A
ATOM 1096 OE2 GLU 528 58.586 75.697 -14. ,591 1.00 33.48 A
ATOM 1097 C GLU 528 56.183 72.926 -17. .091 1.00 33.48 A
ATOM 1098 0 GLU 528 56.912 71.966 -17. ,268 1.00 33.48 A
ATOM 1099 N VAL 529 55.234 72.930 -16. .161 1.00 33.48 A
ATOM 1100 CA VAL 529 55.006 71.721 -15. .389 1.00 33.48 A
ATOM 1101 CB VAL 529 55.096 71.914 -13. .861 1.00 33.48 A
ATOM 1102 CGI VAL 529 56.303 72.758 -13. .505 1.00 33.48 A
ATOM 1103 CG2 VAL 529 53.804 72.471 -13. .340 1.00 33.48 A
ATOM 1104 C VAL 529 53.624 71.230 -15. .704 1.00 33.48 A
ATOM 1105 0 VAL 529 53.358 70.043 -15. .590 1.00 33.48 A
ATOM 1106 N PHE 530 52.733 72.134 -16. .097 1.00 33.48 A
ATOM 1107 CA PHE 530 51.394 71.699 -16. .431 1.00 33.48 A
ATOM 1108 CB PHE 530 50.351 72.789 -16. .142 1.00 33.48 A
ATOM 1109 CG PHE 530 50.424 74.016 -17, .023 1.00 33.48 A
ATOM 1110 CDl PHE 530 50.358 75.283 -16. .449 1.00 33.48 A
ATOM llll CD2 PHE 530 50.410 73.922 -18. .404 1.00 33.48 A
ATOM 1112 CEl PHE 530 50.266 76.426 -17. .230 1.00 33.48 A
ATOM 1113 CE2 PHE 530 50.317 75.069 -19, .197 1.00 33.48 A
ATOM 1114 CZ PHE 530 50.243 76.321 -18. .605 1.00 33.48 A
ATOM 1115 C PHE 530 51.361 71.249 -17. .869 1.00 33.48 A
ATOM 1116 0 PHE 530 50.315 70.878 -18, .388 1.00 33.48 A
ATOM 1117 N SER 531 52.532 71.252 -18. .499 1.00 33.48 A
ATOM 1118 CA SER 531 52.663 70.825 -19. .886 1.00 33.48 A
ATOM 1119 CB SER 531 52.853 72.040 -20. .788 1.00 33.48 A
ATOM 1120 OG SER 531 53.944 72.810 -20, .338 1.00 33.48 A
ATOM 1121 C SER 531 53.816 69.847 -20. .109 1.00 33.48 A
ATOM 1122 0 SER 531 53.792 69.071 -21, .050 1.00 33.48 A
ATOM 1123 N PHE 532 54.822 69.880 -19, .249 1.00 33.48 A
ATOM 1124 CA PHE 532 55.960 68.988 -19, .398 1.00 33.48 A
ATOM 1125 CB PHE 532 57.174 69.767 -19, .907 1.00 33.48 A
ATOM 1126 CG PHE 532 56.959 70.401 -21, .237 1.00 33.48 A
ATOM 1127 CDl PHE 532 56.534 69.653 -22, .308 1.00 33.48 A
ATOM 1128 CD2 PHE 532 57.180 71.744 -21, .423 1.00 33.48 A
ATOM 1129 CEl PHE 532 56.333 70.237 -23, .541 1.00 33.48 A
ATOM 1130 CE2 PHE 532 56.980 72.328 -22, .650 1.00 33.48 A
ATOM 1131 CZ PHE 532 56.556 71.573 -23, .708 1.00 33.48 A
ATOM 1132 C PHE 532 56.307 68.299 -18, .083 1.00 33.48 A
ATOM 1133 0 PHE 532 57.125 67.371 -18, .038 1.00 33.48 A
ATOM 1134 N SER 533 55.692 68.748 -17, .001 1.00 33.48 A
ATOM 1135 CA SER 533 55.980 68.133 -15, .722 1.00 33.48 A
ATOM 1136 CB SER 533 55.609 66.650 -15. .763 1.00 33.48 A
ATOM 1137 OG SER 533 54.275 66.481 -16, .215 1.00 33.48 A
ATOM 1138 C SER 533 57.464 68.280 -15. .420 1.00 33.48 A ATOM 1139 O SER 533 58.104 67.337 -14.965 1.00 33.48 A
ATOM 1140 N ARG 534 58.007 69.465 -15.671 1.00 33.48 A
ATOM 1141 CA ARG 534 59.414 69.729 -15.417 1.00 33.48 A
ATOM 1142 CB ARG 534 59.994 70.490 -16.612 1.00 33.48 A
ATOM 1143 CG ARG 534 61.488 70.792 -16.555 1.00 33.48 A
ATOM 1144 CD ARG 534 61.944 71.476 -17.846 1.00 33.48 A
ATOM 1145 NE ARG 534 61.523 70.687 -18.994 1.00 33.48 A
ATOM 1146 CZ ARG 534 60.907 71.174 -20.066 1.00 33.48 A
ATOM 1147 NH1 ARG 534 60.642 72.474 -20.163 1.00 33.48 A
ATOM 1148 NH2 ARG 534 60.511 70.342 -21.024 1.00 33.48 A
ATOM 1149 C ARG 534 59.606 70.508 -14.097 1.00 33.48 A
ATOM 1150 0 ARG 534 59.720 71.733 -14.086 1.00 33.48 A
ATOM 1151 N TYR 535 59.646 69.768 -12.989 1.00 33.48 A
ATOM 1152 CA TYR 535 59.805 70.326 -11.648 1.00 33.48 A
ATOM 1153 CB TYR 535 59.398 69.287 -10.616 1.00 33.48 A
ATOM 1154 CG TYR 535 57.916 69.025 -10.569 1.00 33.48 A
ATOM 1155 CDl TYR 535 57.080 69.849 -9.847 1.00 33.48 A
ATOM 1156 CEl TYR 535 55.726 69.638 -9.824 1.00 33.48 A
ATOM 1157 CD2 TYR 535 57.349 67.972 -11.273 1.00 33.48 A
ATOM 1158 CE2 TYR 535 55.989 67.752 -11.261 1.00 33.48 A
ATOM 1159 CZ TYR 535 55.178 68.590 -10.532 1.00 33.48 A
ATOM 1160 OH TYR 535 53.809 68.399 -10.493 1.00 33.48 A
ATOM 1161 C TYR 535 61.213 70.804 -11.328 1.00 33.48 A
ATOM 1162 0 TYR 535 62.193 70.149 -11.671 1.00 33.48 A
ATOM 1163 N SER 536 61.309 71.951 -10.660 1.00 33.48 A
ATOM 1164 CA SER 536 62.597 72.516 -10.280 1.00 33.48 A
ATOM 1165 CB SER 536 63.283 73.128 -11.485 1.00 33.48 A
ATOM 1166 OG SER 536 62.561 74.247 -11.939 1.00 33.48 A
ATOM 1167 C SER 536 62.382 73.585 -9.232 1.00 33.48 A
ATOM 1168 0 SER 536 61.250 73.878 -8.875 1.00 33.48 A
ATOM 1169 N SER 537 63.470 74.162 -8.732 1.00 33.48 A
ATOM 1170 CA SER 537 63.369 75.211 -7.726 1.00 33.48 A
ATOM 1171 CB SER 537 64.760 75.744 -7.370 1.00 33.48 A
ATOM 1172 OG SER 537 65.462 74.853 -6.514 1.00 33.48 A
ATOM 1173 C SER 537 62.503 76.342 -8.262 1.00 33.48 A
ATOM 1174 0 SER 537 61.627 76.846 -7.575 1.00 33.48 A
ATOM 1175 N LYS 538 62.766 76.721 -9.508 1.00 33.48 A
ATOM 1176 CA LYS 538 62.035 77.783 -10.192 1.00 33.48 A
ATOM 1177 CB LYS 538 62.691 78.069 -11.545 1.00 33.48 A
ATOM 1178 CG LYS 538 64.073 78.635 -11.406 1.00 33.48 A
ATOM 1179 CD LYS 538 64.051 79.915 -10.590 1.00 33.48 A
ATOM 1180 CE LYS 538 65.454 80.420 -10.280 1.00 33.48 A
ATOM 1181 NZ LYS 538 66.273 80.684 -11.495 1.00 33.48 A
ATOM 1182 C LYS 538 60.578 77.400 -10.394 1.00 33.48 A ATOM 1183 O LYS 538 59.705 78.247 -10.525 1.00 33.48 A
ATOM 1184 N SER 539 60.338 76.104 -10.433 1.00 33.48 A
ATOM 1185 CA SER 539 59.005 75.595 -10.609 1.00 33.48 A
ATOM 1186 CB SER 539 59.058 74.073 -10.763 1.00 33.48 A
ATOM 1187 OG SER 539 57.773 73.507 -10.914 1.00 33.48 A
ATOM 1188 C SER 539 58.284 75.996 -9.338 1.00 33.48 A
ATOM 1189 O SER 539 57.088 76.284 -9.344 1.00 33.48 A
ATOM 1190 N ASP 540 59.036 76.031 -8.246 1.00 33.48 A
ATOM 1191 CA ASP 540 58.483 76.399 -6.955 1.00 33.48 A
ATOM 1192 CB ASP 540 59.343 75.832 -5.825 1.00 33.48 A
ATOM 1193 CG ASP 540 59.027 74.383 -5.531 1.00 33.48 A
ATOM 1194 ODl ASP 540 57.924 73.935 -5.902 1.00 33.48 A
ATOM 1195 OD2 ASP 540 59.865 73.701 -4.920 1.00 33.48 A
ATOM 1196 C ASP 540 58.352 77.902 -6.797 1.00 33.48 A
ATOM 1197 O ASP 540 57.459 78.372 -6.105 1.00 33.48 A
ATOM 1198 N VAL 541 59.245 78.653 -7.434 1.00 33.48 A
ATOM 1199 CA VAL 541 59.197 80.103 -7.364 1.00 33.48 A
ATOM 1200 CB VAL 541 60.346 80.733 -8.126 1.00 33.48 A
ATOM 1201 CGI VAL 541 59.995 82.159 -8.491 1.00 33.48 A
ATOM 1202 CG2 VAL 541 61.577 80.730 -7.273 1.00 33.48 A
ATOM 1203 C VAL 541 57.892 80.641 -7.934 1.00 33.48 A
ATOM 1204 O VAL 541 57.357 81.626 -7.430 1.00 33.48 A
ATOM 1205 N TRP 542 57.388 79.993 -8.982 1.00 33.48 A
ATOM 1206 CA TRP 542 56.142 80.392 -9.613 1.00 33.48 A
ATOM 1207 CB TRP 542 55.904 79.563 -10.878 1.00 33.48 A
ATOM 1208 CG TRP 542 54.536 79.723 -11.519 1.00 33.48 A
ATOM 1209 CD2 TRP 542 54.227 80.408 -12.744 1.00 33.48 A
ATOM 1210 CE2 TRP 542 52.839 80.337 -12.921 1.00 33.48 A
ATOM 1211 CE3 TRP 542 54.991 81.077 -13.703 1.00 33.48 A
ATOM 1212 CDl TRP 542 53.350 79.274 -11.030 1.00 33.48 A
ATOM 1213 NEl TRP 542 52.328 79.638 -11.861 1.00 33.48 A
ATOM 1214 CZ2 TRP 542 52.194 80.912 -14.015 1.00 33.48 A
ATOM 1215 CZ3 TRP 542 54.344 81.646 -14.787 1.00 33.48 A
ATOM 1216 CH2 TRP 542 52.964 81.560 -14.931 1.00 33.48 A
ATOM 1217 C TRP 542 54.999 80.198 -8.631 1.00 33.48 A
ATOM 1218 O TRP 542 54.093 81.018 -8.545 1.00 33.48 A
ATOM 1219 N SER 543 55.047 79.116 -7.874 1.00 33.48 A
ATOM 1220 CA SER 543 54.000 78.839 -6.908 1.00 33.48 A
ATOM 1221 CB SER 543 54.126 77.418 -6.398 1.00 33.48 A
ATOM 1222 OG SER 543 54.192 76.526 -7.487 1.00 33.48 A
ATOM 1223 C SER 543 54.073 79.792 -5.737 1.00 33.48 A
ATOM 1224 O SER 543 53.055 80.125 -5.125 1.00 33.48 A
ATOM 1225 N PHE 544 55.282 80.227 -5.410 1.00 33.48 A
ATOM 1226 CA PHE 544 55.431 81.144 -4.303 1.00 33.48 A ATOM 1227 CB PHE 544 56.911 81.459 -4.049 1.00 33.48 A
ATOM 1228 CG PHE 544 57.126 82.397 -2.898 1.00 33.48 A
ATOM 1229 CDl PHE 544 56.866 81.992 -1.607 1.00 33.48 A
ATOM 1230 CD2 PHE 544 57.499 83.708 -3.119 1.00 33.48 A
ATOM 1231 CEl PHE 544 56.967 82.870 -0.580 1.00 33.48 A
ATOM 1232 CE2 PHE 544 57.598 84.579 -2.093 1.00 33.48 A
ATOM 1233 CZ PHE 544 57.333 84.164 -0.824 1.00 33.48 A
ATOM 1234 C PHE 544 54.663 82.408 -4.665 1.00 33.48 A
ATOM 1235 O PHE 544 54.110 83.077 -3.806 1.00 33.48 A
ATOM 1236 N GLY 545 54.630 82.721 -5.953 1.00 33.48 A
ATOM 1237 CA GLY 545 53.909 83.892 -6.407 1.00 33.48 A
ATOM 1238 C GLY 545 52.418 83.721 -6.170 1.00 33.48 A
ATOM 1239 O GLY 545 51.734 84.638 -5.705 1.00 33.48 A
ATOM 1240 N VAL 546 51.900 82.543 -6.494 1.00 33.48 A
ATOM 1241 CA VAL 546 50.487 82.297 -6.289 1.00 33.48 A
ATOM 1242 CB VAL 546 50.067 80.916 -6.815 1.00 33.48 A
ATOM 1243 CGI VAL 546 48.603 80.679 -6.516 1.00 33.48 A
ATOM 1244 CG2 VAL 546 50.308 80.842 -8.305 1.00 33.48 A
ATOM 1245 C VAL 546 50.217 82.385 -4.797 1.00 33.48 A
ATOM 1246 O VAL 546 49.218 82.954 -4.367 1.00 33.48 A
ATOM 1247 N LEU 547 51.127 81.838 -4.005 1.00 33.48 A
ATOM 1248 CA LEU 547 50.980 81.868 -2.559 1.00 33.48 A
ATOM 1249 CB LEU 547 52.149 81.125 -1.917 1.00 33.48 A
ATOM 1250 CG LEU 547 52.082 80.795 -0.433 1.00 33.48 A
ATOM 1251 CDl LEU 547 52.908 79.564 -0.183 1.00 33.48 A
ATOM 1252 CD2 LEU 547 52.582 81.954 0.397 1.00 33.48 A
ATOM 1253 C LEU 547 50.896 83.311 -2.045 1.00 33.48 A
ATOM 1254 O LEU 547 50.009 83.638 -1.271 1.00 33.48 A
ATOM 1255 N MET 548 51.823 84.165 -2.474 1.00 33.48 A
ATOM 1256 CA MET 548 51.832 85.570 -2.069 1.00 33.48 A
ATOM 1257 CB MET 548 52.911 86.356 -2.802 1.00 33.48 A
ATOM 1258 CG MET 548 54.325 86.115 -2.363 1.00 33.48 A
ATOM 1259 SD MET 548 55.360 87.191 -3.344 1.00 33.48 A
ATOM 1260 CE MET 548 55.096 88.736 -2.526 1.00 33.48 A
ATOM 1261 C MET 548 50.495 86.173 -2.442 1.00 33.48 A
ATOM 1262 O MET 548 49.976 87.048 -1.740 1.00 33.48 A
ATOM 1263 N TRP 549 49.957 85.722 -3.576 1.00 33.48 A
ATOM 1264 CA TRP 549 48.665 86.201 -4.020 1.00 33.48 A
ATOM 1265 CB TRP 549 48.303 85.636 -5.375 1.00 33.48 A
ATOM 1266 CG TRP 549 47.001 86.154 -5.889 1.00 33.48 A
ATOM 1267 CD2 TRP 549 45.711 85.568 -5.691 1.00 33.48 A
ATOM 1268 CE2 TRP 549 44.780 86.372 -6.371 1.00 33.48 A
ATOM 1269 CE3 TRP 549 45.254 84.439 -5.006 1.00 33.48 A
ATOM 1270 CDl TRP 549 46.801 87.266 -6.655 1.00 33.48 A ATOM 1271 NE1 TRP 549 45.472 87.402 -6.952 1.00 33,.48 A
ATOM 1272 CZ2 TRP 549 43.424 86.084 -6.385 1.00 33, .48 A
ATOM 1273 CZ3 TRP 549 43.915 84.156 -5.021 1.00 33, .48 A
ATOM 1274 CH2 TRP 549 43.011 84.973 -5.705 1.00 33, .48 A
ATOM 1275 c TRP 549 47.666 85.713 -2.996 1.00 33, .48 A
ATOM 1276 O TRP 549 46.926 86.504 -2.434 1.00 33, .48 A
ATOM 1277 N GLU 550 47.654 84.411 -2.736 1.00 33, .48 A
ATOM 1278 CA GLU 550 46.730 83.873 -1.751 1.00 33, .48 A
ATOM 1279 CB GLU 550 46.961 82.370 -1.515 1.00 33 .48 A
ATOM 1280 CG GLU 550 46.655 81.479 -2.710 1.00 33 .48 A
ATOM 1281 CD GLU 550 46.940 80.005 -2.446 1.00 33 .48 A
ATOM 1282 OEl GLU 550 46.032 79.281 -1.985 1.00 33, .48 A
ATOM 1283 OE2 GLU 550 48.080 79.567 -2.694 1.00 33, .48 A
ATOM 1284 C GLU 550 46.901 84.629 -0.438 1.00 33, .48 A
ATOM 1285 O GLU 550 45.934 85.137 0.119 1.00 33, .48 A
ATOM 1286 N VAL 551 48.126 84.719 0.055 1.00 33, .48 A
ATOM 1287 CA VAL 551 48.363 85.409 1.309 1.00 33, .48 A
ATOM 1288 CB VAL 551 49.849 85.374 1.689 1.00 33, .48 A
ATOM 1289 CGI VAL 551 50.140 86.396 2.766 1.00 33, .48 A
ATOM 1290 CG2 VAL 551 50.206 83.994 2.188 1.00 33, .48 A
ATOM 1291 C VAL 551 47.889 86.856 1.300 1.00 33, .48 A
ATOM 1292 O VAL 551 47.340 87.339 2.290 1.00 33, .48 A
ATOM 1293 N PHE 552 48.077 87.558 0.191 1.00 33, .48 A
ATOM 1294 CA PHE 552 47.648 88.949 0.150 1.00 33, .48 A
ATOM 1295 CB PHE 552 48.552 89.745 -0.766 1.00 33, .48 A
ATOM 1296 CG PHE 552 49.680 90.391 -0.054 1.00 33, .48 A
ATOM 1297 CDl PHE 552 49.436 91.334 0.913 1.00 33, .48 A
ATOM 1298 CD2 PHE 552 50.980 90.075 -0.360 1.00 33 .48 A
ATOM 1299 CEl PHE 552 50.463 91.951 1.555 1.00 33 .48 A
ATOM 1300 CE2 PHE 552 52.016 90.692 0.281 1.00 33 .48 A
ATOM 1301 CZ PHE 552 51.757 91.632 1.238 1.00 33 .48 A
ATOM 1302 c PHE 552 46.199 89.166 -0.236 1.00 33 .48 A
ATOM 1303 0 PHE 552 45.675 90.265 -0.122 1.00 33 .48 A
ATOM 1304 N SER 553 45.551 88.110 -0.695 1.00 33 .48 A
ATOM 1305 CA SER 553 44.158 88.205 -1.059 1.00 33 .48 A
ATOM 1306 CB SER 553 43.897 87.446 -2.354 1.00 33 .48 A
ATOM 1307 OG SER 553 43.688 86.080 -2.083 1.00 33 .48 A
ATOM 1308 C SER 553 43.359 87.602 0.093 1.00 33 .48 A
ATOM 1309 O SER 553 42.198 87.248 -0.054 1.00 33 .48 A
ATOM 1310 N GLU 554 44.010 87.503 1.245 1.00 33 .48 A
ATOM 1311 CA GLU 554 43.413 86.970 2.462 1.00 33 .48 A
ATOM 1312 CB GLU 554 42.557 88.047 3.135 1.00 33 .48 A
ATOM 1313 CG GLU 554 43.349 88.936 4.088 1.00 33 .48 A
ATOM 1314 CD GLU 554 42.581 90.170 4.548 1.00 33, .48 A ATOM 1315 OEl GLU 554 43.139 90.962 5.347 1.00 33.48 A
ATOM 1316 OE2 GLU 554 41.420 90.355 4.108 1.00 33.48 A
ATOM 1317 C GLU 554 42.607 85.683 2.321 1.00 33.48 A
ATOM 1318 O GLU 554 41.593 85.496 3.005 1.00 33.48 A
ATOM 1319 N GLY 555 43.053 84.784 1.449 1.00 33.48 A
ATOM 1320 CA GLY 555 42.327 83.536 1.290 1.00 33.48 A
ATOM 1321 C GLY 555 41.519 83.346 0.016 1.00 33.48 A
ATOM 1322 O GLY 555 40.995 82.250 -0.214 1.00 33.48 A
ATOM 1323 N LYS 556 41.397 84.385 -0.808 1.00 33.48 A
ATOM 1324 CA LYS 556 40.661 84.261 -2.061 1.00 33.48 A
ATOM 1325 CB LYS 556 40.780 85.546 -2.888 1.00 33.48 A
ATOM 1326 CG LYS 556 39.984 86.740 -2.351 1.00 33.48 A
ATOM 1327 CD LYS 556 40.047 87.922 -3.324 1.00 33.48 A
ATOM 1328 CE LYS 556 39.475 87.536 -4.705 1.00 33.48 A
ATOM 1329 NZ LYS 556 39.673 88.576 -5.786 1.00 33.48 A
ATOM 1330 C LYS 556 41.251 83.092 -2.843 1.00 33.48 A
ATOM 1331 0 LYS 556 42.379 82.699 -2.603 1.00 33.48 A
ATOM 1332 N ILE 557 40.501 82.523 -3.773 1.00 33.48 A
ATOM 1333 CA ILE 557 41.028 81.408 -4.544 1.00 33.48 A
ATOM 1334 CB ILE 557 39.976 80.327 -4.748 1.00 33.48 A
ATOM 1335 CG2 ILE 557 40.370 79.438 -5.889 1.00 33.48 A
ATOM 1336 CGl ILE 557 39.815 79.522 -3.463 1.00 33.48 A
ATOM 1337 CDl ILE 557 38.772 78.427 -3.552 1.00 33.48 A
ATOM 1338 C ILE 557 41.518 81.854 -5.903 1.00 33.48 A
ATOM 1339 0 ILE 557 40.913 82.719 -6.528 1.00 33.48 A
ATOM 1340 N PRO 558 42.638 81.279 -6.371 1.00 33.48 A
ATOM 1341 CD PRO 558 43.574 80.453 -5.599 1.00 33.48 A
ATOM 1342 CA PRO 558 43.225 81.610 -7.667 1.00 33.48 A
ATOM 1343 CB PRO 558 44.555 80.868 -7.636 1.00 33.48 A
ATOM 1344 CG PRO 558 44.885 80.841 -6.209 1.00 33.48 A
ATOM 1345 C PRO 558 42.322 81.148 -8.802 1.00 33.48 A
ATOM 1346 0 PRO 558 41.920 79.990 -8.866 1.00 33.48 A
ATOM 1347 N TYR 559 42.009 82.060 -9.707 1.00 33.48 A
ATOM 1348 CA TYR 559 41.136 81.726 -10.819 1.00 33.48 A
ATOM 1349 CB TYR 559 41.888 80.865 -11.837 1.00 33.48 A
ATOM 1350 CG TYR 559 43.358 81.209 -11.962 1.00 33.48 A
ATOM 1351 CDl TYR 559 44.288 80.634 -11.114 1.00 33.48 A
ATOM 1352 CEl TYR 559 45.626 80.927 -11.210 1.00 33.48 A
ATOM 1353 CD2 TYR 559 43.815 82.102 -12.920 1.00 33.48 A
ATOM 1354 CE2 TYR 559 45.156 82.401 -13.021 1.00 33.48 A
ATOM 1355 CZ TYR 559 46.055 81.804 -12.157 1.00 33.48 A
ATOM 1356 OH TYR 559 47.400 82.069 -12.218 1.00 33.48 A
ATOM 1357 C TYR 559 39.915 80.988 -10.262 1.00 33.48 A
ATOM 1358 0 TYR 559 39.668 79.822 -10.571 1.00 33.48 A ATOM 1359 N GLU 560 39.174 81.707 -9.421 1.00 33.48 A
ATOM 1360 CA GLU 560 37.963 81.237 -8.735 1.00 33.48 A
ATOM 1361 CB GLU 560 37.154 82.441 -8.275 1.00 33.48 A
ATOM 1362 CG GLU 560 35.684 82.176 -8.134 1.00 33.48 A
ATOM 1363 CD GLU 560 35.340 81.439 -6.857 1.00 33.48 A
ATOM 1364 OEl GLU 560 35.880 81.821 -5.788 1.00 33.48 A
ATOM 1365 OE2 GLU 560 34.517 80.493 -6.921 1.00 33.48 A
ATOM 1366 C GLU 560 37.051 80.320 -9.539 1.00 33.48 A
ATOM 1367 0 GLU 560 36.848 79.145 -9.184 1.00 33.48 A
ATOM 1368 N ASN 561 36.481 80.862 -10.613 1.00 33.48 A
ATOM 1369 CA ASN 561 35.591 80.072 -11.459 1.00 33.48 A
ATOM 1370 CB ASN 561 34.191 80.701 -11.437 1.00 33.48 A
ATOM 1371 CG ASN 561 33.593 80.726 -10.024 1.00 33.48 A
ATOM 1372 ODl ASN 561 32.931 81.695 -9.626 1.00 33.48 A
ATOM 1373 ND2 ASN 561 33.830 79.651 -9.262 1.00 33.48 A
ATOM 1374 C ASN 561 36.164 79.968 -12.876 1.00 33.48 A
ATOM 1375 0 ASN 561 35.595 80.459 -13.861 1.00 33.48 A
ATOM 1376 N ARG 562 37.327 79.330 -12.947 1.00 33.48 A
ATOM 1377 CA ARG 562 38.020 79.112 -14.199 1.00 33.48 A
ATOM 1378 CB ARG 562 39.225 80.030 -14.280 1.00 33.48 A
ATOM 1379 CG ARG 562 38.852 81.452 -14.585 1.00 33.48 A
ATOM 1380 CD ARG 562 38.225 81.522 -15.956 1.00 33.48 A
ATOM 1381 NE ARG 562 38.883 82.501 -16.819 1.00 33.48 A
ATOM 1382 CZ ARG 562 38.711 82.552 -18.137 1.00 33.48 A
ATOM 1383 NHl ARG 562 37.905 81.676 -18.722 1.00 33.48 A
ATOM 1384 NH2 ARG 562 39.337 83.475 -18.869 1.00 33.48 A
ATOM 1385 C ARG 562 38.442 77.652 -14.286 1.00 33.48 A
ATOM 1386 0 ARG 562 38.912 77.069 -13.316 1.00 33.48 A
ATOM 1387 N SER 563 38.245 77.060 -15.453 1.00 33.48 A
ATOM 1388 CA SER 563 38.582 75.666 -15.658 1.00 33.48 A
ATOM 1389 CB SER 563 37.737 75.105 -16.805 1.00 33.48 A
ATOM 1390 OG SER 563 37.713 75.984 -17.917 1.00 33.48 A
ATOM 1391 C SER 563 40.068 75.500 -15.951 1.00 33.48 A
ATOM 1392 0 SER 563 40.655 76.323 -16.652 1.00 33.48 A
ATOM 1393 N ASN 564 40.673 74.447 -15.401 1.00 33.48 A
ATOM 1394 CA ASN 564 42.086 74.186 -15.613 1.00 33.48 A
ATOM 1395 CB ASN 564 42.394 72.709 -15.427 1.00 33.48 A
ATOM 1396 CG ASN 564 42.308 72.278 -13.980 1.00 33.48 A
ATOM 1397 ODl ASN 564 41.861 73.041 -13.122 1.00 33.48 A
ATOM 1398 ND2 ASN 564 42.732 71.046 -13.696 1.00 33.48 A
ATOM 1399 C ASN 564 42.451 74.590 -17.017 1.00 33.48 A
ATOM 1400 0 ASN 564 43.453 75.273 -17.234 1.00 33.48 A
ATOM 1401 N SER 565 41.626 74.185 -17.977 1.00 33.48 A
ATOM 1402 CA SER 565 41.893 74.517 -19.369 1.00 33.48 A ATOM 1403 CB SER 565 40.832 73.909 -20.290 1.00 33.48 A
ATOM 1404 OG SER 565 39.536 74.368 -19.941 1.00 33.48 A
ATOM 1405 C SER 565 41.925 76.028 -19.526 1.00 33.48 A
ATOM 1406 0 SER 565 42.833 76.567 -20.144 1.00 33.48 A
ATOM 1407 N GLU 566 40.939 76.711 -18.960 1.00 33.48 A
ATOM 1408 CA GLU 566 40.897 78.165 -19.043 1.00 33.48 A
ATOM 1409 CB GLU 566 39.619 78.698 -18.371 1.00 33.48 A
ATOM 1410 CG GLU 566 38.342 78.507 -19.205 1.00 33.48 A
ATOM 1411 CD GLU 566 37.073 78.817 -18.416 1.00 33.48 A
ATOM 1412 OEl GLU 566 35.960 78.674 -18.982 1.00 33.48 A
ATOM 1413 OE2 GLU 566 37.189 79.200 -17.226 1.00 33.48 A
ATOM 1414 C GLU 566 42.142 78.816 -18.411 1.00 33.48 A
ATOM 1415 0 GLU 566 42.649 79.820 -18.917 1.00 33.48 A
ATOM 1416 N VAL 567 42.625 78.238 -17.311 1.00 33.48 A
ATOM 1417 CA VAL 567 43.807 78.752 -16.621 1.00 33.48 A
ATOM 1418 CB VAL 567 44.044 78.047 -15.258 1.00 33.48 A
ATOM 1419 CGl VAL 567 45.382 78.468 -14.681 1.00 33.48 A
ATOM 1420 CG2 VAL 567 42.941 78.396 -14.281 1.00 33.48 A
ATOM 1421 C VAL 567 45.027 78.512 -17.482 1.00 33.48 A
ATOM 1422 0 VAL 567 45.901 79.367 -17.578 1.00 33.48 A
ATOM 1423 N VAL 568 45.087 77.343 -18.104 1.00 33.48 A
ATOM 1424 CA VAL 568 46.217 77.012 -18.950 1.00 33.48 A
ATOM 1425 CB VAL 568 46.229 75.521 -19.289 1.00 33.48 A
ATOM 1426 CGl VAL 568 47.208 75.246 -20.397 1.00 33.48 A
ATOM 1427 CG2 VAL 568 46.632 74.738 -18.071 1.00 33.48 A
ATOM 1428 C VAL 568 46.242 77.840 -20.231 1.00 33.48 A
ATOM 1429 0 VAL 568 47.286 78.339 -20.624 1.00 33.48 A
ATOM 1430 N GLU 569 45.102 77.989 -20.890 1.00 33.48 A
ATOM 1431 CA GLU 569 45.055 78.796 -22.103 1.00 33.48 A
ATOM 1432 CB GLU 569 43.680 78.702 -22.766 1.00 33.48 A
ATOM 1433 CG GLU 569 43.442 79.712 -23.888 1.00 33.48 A
ATOM 1434 CD GLU 569 44.485 79.614 -24.997 1.00 33.48 A
ATOM 1435 OEl GLU 569 45.105 78.523 -25.123 1.00 33.48 A
ATOM 1436 OE2 GLU 569 44.675 80.612 -25.748 1.00 33.48 A
ATOM 1437 C GLU 569 45.320 80.237 -21.700 1.00 33.48 A
ATOM 1438 0 GLU 569 45.909 81.011 -22.455 1.00 33.48 A
ATOM 1439 N ASP 570 44.884 80.602 -20.502 1.00 33.48 A
ATOM 1440 CA ASP 570 45.091 81.958 -20.047 1.00 33.48 A
ATOM 1441 CB ASP 570 44.095 82.334 -18.943 1.00 33.48 A
ATOM 1442 CG ASP 570 42.843 83.041 -19.489 1.00 33.48 A
ATOM 1443 ODl ASP 570 41.991 83.458 -18.668 1.00 33.48 A
ATOM 1444 OD2 ASP 570 42.706 83.187 -20.730 1.00 33.48 A
ATOM 1445 C ASP 570 46.509 82.190 -19.582 1.00 33.48 A
ATOM 1446 0 ASP 570 47.073 83.247 -19.851 1.00 33.48 A ATOM 1447 N ILE 571 47.107 81.224 -18.894 1.00 33.48 A
ATOM 1448 CA ILE 571 48.489 81.430 -18. 455 1.00 33.48 A
ATOM 1449 CB ILE 571 48.962 80.386 -17. 453 1.00 33.48 A
ATOM 1450 CG2 ILE 571 50.460 80.499 -17. ,283 1.00 33.48 A
ATOM 1451 CGl ILE 571 48.324 80.651 -16. ,097 1.00 33.48 A
ATOM 1452 CDl ILE 571 48.725 81.988 -15. 528 1.00 33.48 A
ATOM 1453 C ILE 571 49.454 81.410 -19. ,625 1.00 33.48 A
ATOM 1454 0 ILE 571 50.358 82.242 -19. ,709 1.00 33.48 A
ATOM 1455 N SER 572 49.238 80.470 -20. ,536 1.00 33.48 A
ATOM 1456 CA SER 572 50.083 80.331 -21. .704 1.00 33.48 A
ATOM 1457 CB SER 572 49.723 79.062 -22. ,473 1.00 33.48 A
ATOM 1458 OG SER 572 48.435 79.158 -23. ,034 1.00 33.48 A
ATOM 1459 C SER 572 49.993 81.525 -22. ,634 1.00 33.48 A
ATOM 1460 0 SER 572 50.721 81.602 -23. .623 1.00 33.48 A
ATOM 1461 N THR 573 49.109 82.464 -22. .335 1.00 33.48 A
ATOM 1462 CA THR 573 49.003 83.630 -23. .195 1.00 33.48 A
ATOM 1463 CB THR 573 47.640 83.674 -23, .911 1.00 33.48 A
ATOM 1464 OGl THR 573 46.594 83.945 -22. ,973 1.00 33.48 A
ATOM 1465 CG2 THR 573 47.370 82.328 -24. .571 1.00 33.48 A
ATOM 1466 C THR 573 49.275 84.940 -22. .463 1.00 33.48 A
ATOM 1467 0 THR 573 48.750 85.989 -22. .825 1.00 33.48 A
ATOM 1468 N GLY 574 50.086 84.859 -21, .413 1.00 33.48 A
ATOM 1469 CA GLY 574 50.490 86.047 -20, .688 1.00 33.48 A
ATOM 1470 C GLY 574 49.631 86.660 -19, .614 1.00 33.48 A
ATOM 1471 0 GLY 574 50.053 87.624 -18. .985 1.00 33.48 A
ATOM 1472 N PHE 575 48.443 86.124 -19, .383 1.00 33.48 A
ATOM 1473 CA PHE 575 47.587 86.689 -18, .353 1.00 33.48 A
ATOM 1474 CB PHE 575 46.125 86.405 -18, .672 1.00 33.48 A
ATOM 1475 CG PHE 575 45.651 87.113 -19, .895 1.00 33.48 A
ATOM 1476 CDl PHE 575 45.510 86.441 -21 .088 1.00 33.48 A
ATOM 1477 CD2 PHE 575 45.431 88.473 -19, .869 1.00 33.48 A
ATOM 1478 CEl PHE 575 45.163 87.110 -22, .229 1.00 33.48 A
ATOM 1479 CE2 PHE 575 45.085 89.143 -21 .007 1.00 33.48 A
ATOM 1480 CZ PHE 575 44.951 88.461 -22 .191 1.00 33.48 A
ATOM 1481 C PHE 575 47.950 86.194 -16 .972 1.00 33.48 A
ATOM 1482 0 PHE 575 48.577 85.159 -16 .824 1.00 33.48 A
ATOM 1483 N ARG 576 47.548 86.942 -15, .957 1.00 33.48 A
ATOM 1484 CA ARG 576 47.874 86.595 -14, .584 1.00 33.48 A
ATOM 1485 CB ARG 576 49.234 87.205 -14, .231 1.00 33.48 A
ATOM 1486 CG ARG 576 50.389 86.789 -15, .148 1.00 33.48 A
ATOM 1487 CD ARG 576 50.906 85.399 -14 .815 1.00 33.48 A
ATOM 1488 NE ARG 576 52.129 85.073 -15 .539 1.00 33.48 A
ATOM 1489 CZ ARG 576 52.179 84.663 -16 .799 1.00 33.48 A
ATOM 1490 NHl ARG 576 51.071 84.520 -17, .496 1.00 33.48 A ATOM 1491 NH2 ARG 576 53.337 84.386 -17.363 1.00 33.48 A
ATOM 1492 C ARG 576 46.827 87.079 -13.579 1.00 33.48 A
ATOM 1493 O ARG 576 45.978 87.912 -13.896 1.00 33.48 A
ATOM 1494 N LEU 577 46.896 86.546 -12.363 1.00 33.48 A
ATOM 1495 CA LEU 577 45.974 86.937 -11.303 1.00 33.48 A
ATOM 1496 CB LEU 577 46.347 86.245 -9.981 1.00 33.48 A
ATOM 1497 CG LEU 577 46.553 84.725 -9.927 1.00 33.48 A
ATOM 1498 CDl LEU 577 47.284 84.351 -8.650 1.00 33.48 A
ATOM 1499 CD2 LEU 577 45.223 84.015 -10.009 1.00 33.48 A
ATOM 1500 C LEU 577 46.126 88.447 -11.154 1.00 33.48 A
ATOM 1501 O LEU 577 47.210 88.987 -11.376 1.00 33.48 A
ATOM 1502 N TYR 578 45.050 89.131 -10.780 1.00 33.48 A
ATOM 1503 CA TYR 578 45.119 90.580 -10.623 1.00 33.48 A
ATOM 1504 CB TYR 578 43.735 91.214 -10.783 1.00 33.48 A
ATOM 1505 CG TYR 578 43.185 91.067 -12.174 1.00 33.48 A
ATOM 1506 CDl TYR 578 42.643 89.869 -12.591 1.00 33.48 A
ATOM 1507 CEl TYR 578 42.231 89.688 -13.878 1.00 33.48 A
ATOM 1508 CD2 TYR 578 43.292 92.093 -13.096 1.00 33.48 A
ATOM 1509 CE2 TYR 578 42.883 91.921 -14.394 1.00 33.48 A
ATOM 1510 CZ TYR 578 42.357 90.710 -14.777 1.00 33.48 A
ATOM 1511 OH TYR 578 41.987 90.485 -16.076 1.00 33.48 A
ATOM 1512 C TYR 578 45.731 91.021 -9.308 1.00 33.48 A
ATOM 1513 O TYR 578 45.888 90.238 -8.385 1.00 33.48 A
ATOM 1514 N LYS 579 46.079 92.294 -9.239 1.00 33.48 A
ATOM 1515 CA LYS 579 46.679 92.854 -8.050 1.00 33.48 A
ATOM 1516 CB LYS 579 47.180 94.257 -8.361 1.00 33.48 A
ATOM 1517 CG LYS 579 47.411 95.120 -7.135 1.00 33.48 A
ATOM 1518 CD LYS 579 47.870 96.502 -7.538 1.00 33.48 A
ATOM 1519 CE LYS 579 47.730 97.461 -6.394 1.00 33.48 A
ATOM 1520 NZ LYS 579 48.386 96.876 -5.223 1.00 33.48 A
ATOM 1521 C LYS 579 45.749 92.922 -6.845 1.00 33.48 A
ATOM 1522 0 LYS 579 44.749 93.629 -6.860 1.00 33.48 A
ATOM 1523 N PRO 580 46.042 92.163 -5.789 1.00 33.48 A
ATOM 1524 CD PRO 580 46.873 90.967 -5.624 1.00 33.48 A
ATOM 1525 CA PRO 580 45.112 92.308 -4.676 1.00 33.48 A
ATOM 1526 CB PRO 580 45.607 91.274 -3.667 1.00 33.48 A
ATOM 1527 CG PRO 580 46.976 90.897 -4.147 1.00 33.48 A
ATOM 1528 C PRO 580 45.160 93.740 -4.149 1.00 33.48 A
ATOM 1529 0 PRO 580 46.079 94.494 -4.438 1.00 33.48 A
ATOM 1530 N ARG 581 44.156 94.134 -3.387 1.00 33.48 A
ATOM 1531 CA ARG 581 44.144 95.488 -2.879 1.00 33.48 A
ATOM 1532 CB ARG 581 42.763 95.844 -2.309 1.00 33.48 A
ATOM 1533 CG ARG 581 41.605 95.582 -3.266 1.00 33.48 A
ATOM 1534 CD ARG 581 40.376 96.458 -2.958 1.00 33.48 A ATOM 1535 NE ARG 581 39.330 96.302 -3.974 1.00 33.48 A
ATOM 1536 CZ ARG 581 38.469 95.286 -4.008 1.00 33.48 A
ATOM 1537 NHl ARG 581 38.526 94.342 -3.070 1.00 33.48 A
ATOM 1538 NH2 ARG 581 37.569 95.197 -4.988 1.00 33.48 A
ATOM 1539 C ARG 581 45.198 95.634 -1.806 1.00 33.48 A
ATOM 1540 0 ARG 581 45.884 96.639 -1.745 1.00 33.48 A
ATOM 1541 N LEU 582 45.333 94.617 -0.964 1.00 33.48 A
ATOM 1542 CA LEU 582 46.292 94.663 0.130 1.00 33.48 A
ATOM 1543 CB LEU 582 45.998 93.546 1.123 1.00 33.48 A
ATOM 1544 CG LEU 582 44.754 93.847 1.952 1.00 33.48 A
ATOM 1545 CDl LEU 582 44.461 92.722 2.951 1.00 33.48 A
ATOM 1546 CD2 LEU 582 44.996 95.157 2.660 1.00 33.48 A
ATOM 1547 C LEU 582 47.757 94.630 -0.266 1.00 33.48 A
ATOM 1548 0 LEU 582 48.623 94.996 0.529 1.00 33.48 A
ATOM 1549 N ALA 583 48.046 94.193 -1.485 1.00 33.48 A
ATOM 1550 CA ALA 583 49.425 94.158 -1.938 1.00 33.48 A
ATOM 1551 CB ALA 583 49.547 93.331 -3.194 1.00 33.48 A
ATOM 1552 C ALA 583 49.812 95.594 -2.217 1.00 33.48 A
ATOM 1553 0 ALA 583 49.155 96.517 -1.764 1.00 33.48 A
ATOM 1554 N SER 584 50.894 95.786 -2.945 1.00 33.48 A
ATOM 1555 CA SER 584 51.326 97.120 -3.295 1.00 33.48 A
ATOM 1556 CB SER 584 52.352 97.661 -2.296 1.00 33.48 A
ATOM 1557 OG SER 584 53.595 97.014 -2.420 1.00 33.48 A
ATOM 1558 C SER 584 51.937 96.959 -4.663 1.00 33.48 A
ATOM 1559 0 SER 584 52.213 95.851 -5.102 1.00 33.48 A
ATOM 1560 N THR 585 52.144 98.056 -5.355 1.00 33.48 A
ATOM 1561 CA THR 585 52.692 97.955 -6.678 1.00 33.48 A
ATOM 1562 CB THR 585 52.885 99.325 -7.229 1.00 33.48 A
ATOM 1563 OGl THR 585 53.542 100.115 -6.234 1.00 33.48 A
ATOM 1564 CG2 THR 585 51.528 99.945 -7.581 1.00 33.48 A
ATOM 1565 C THR 585 54.011 97.199 -6.678 1.00 33.48 A
ATOM 1566 0 THR 585 54.373 96.556 -7.662 1.00 33.48 A
ATOM 1567 N HIS 586 54.729 97.260 -5.564 1.00 33.48 A
ATOM 1568 CA HIS 586 56.008 96.577 -5.497 1.00 33.48 A
ATOM 1569 CB HIS 586 56.922 97.219 -4.452 1.00 33.48 A
ATOM 1570 CG HIS 586 58.341 96.732 -4.516 1.00 33.48 A
ATOM 1571 CD2 HIS 586 59.261 96.530 -3.542 1.00 33.48 A
ATOM 1572 NDl HIS 586 58.972 96.427 -5.706 1.00 33.48 A
ATOM 1573 CEl HIS 586 60.216 96.058 -5.463 1.00 33.48 A
ATOM 1574 NE2 HIS 586 60.418 96.113 -4.158 1.00 33.48 A
ATOM 1575 C HIS 586 55.839 95.104 -5.203 1.00 33.48 A
ATOM 1576 0 HIS 586 56.516 94.275 -5.802 1.00 33.48 A
ATOM 1577 N VAL 587 54.941 94.777 -4.283 1.00 33.48 A
ATOM 1578 CA VAL 587 54.693 93.386 -3.938 1.00 33.48 A
Figure imgf000072_0001
ATOM 1579 CB VAL 587 53.668 93.269 -2.805 1.00 33.48 A
ATOM 1580 CGl VAL 587 53.101 91.872 -2.758 1.00 33.48 A
ATOM 1581 CG2 VAL 587 54.326 93.589 -1.498 1.00 33.48 A
ATOM 1582 C VAL 587 54.154 92.641 -5.144 1.00 33.48 A
ATOM 1583 O VAL 587 54.440 91.467 -5.338 1.00 33.48 A
ATOM 1584 N TYR 588 53.373 93.346 -5.953 1.00 33.48 A
ATOM 1585 CA TYR 588 52.765 92.757 -7.131 1.00 33.48 A
ATOM 1586 CB TYR 588 51.607 93.639 -7.620 1.00 33.48 A
ATOM 1587 CG TYR 588 50.782 93.006 -8.717 1.00 33.48 A
ATOM 1588 CDl TYR 588 50.214 91.755 -8.545 1.00 33.48 A
ATOM 1589 CEl TYR 588 49.515 91.147 -9.561 1.00 33.48 A
ATOM 1590 CD2 TYR 588 50.619 93.635 -9.941 1.00 33.48 A
ATOM 1591 CE2 TYR 588 49.927 93.032 -10.961 1.00 33.48 A
ATOM 1592 CZ TYR 588 49.378 91.785 -10.767 1.00 33.48 A
ATOM 1593 OH TYR 588 48.703 91.168 -11.793 1.00 33.48 A
ATOM 1594 C TYR 588 53.809 92.574 -8.219 1.00 33.48 A
ATOM 1595 O TYR 588 53.788 91.583 -8.949 1.00 33.48 A
ATOM 1596 N GLN 589 54.721 93.533 -8.327 1.00 33.48 A
ATOM 1597 CA GLN 589 55.794 93.450 -9.314 1.00 33.48 A
ATOM 1598 CB GLN 589 56.851 94.511 -9.049 1.00 33.48 A
ATOM 1599 CG GLN 589 56.864 95.642 -10.036 1.00 33.48 A
ATOM 1600 CD GLN 589 57.800 96.739 -9.606 1.00 33.48 A
ATOM 1601 OEl GLN 589 57.899 97.774 -10.261 1.00 33.48 A
ATOM 1602 NE2 GLN 589 58.502 96.516 -8.497 1.00 33.48 A
ATOM 1603 C GLN 589 56.435 92.099 -9.140 1.00 33.48 A
ATOM 1604 O GLN 589 56.543 91.327 -10.086 1.00 33.48 A
ATOM 1605 N ILE 590 56.856 91.839 -7.905 1.00 33.48 A
ATOM 1606 CA ILE 590 57.493 90.591 -7.522 1.00 33.48 A
ATOM 1607 CB ILE 590 57.677 90.489 -5.992 1.00 33.48 A
ATOM 1608 CG2 ILE 590 58.180 89.110 -5.623 1.00 33.48 A
ATOM 1609 CGl ILE 590 58.672 91.525 -5.497 1.00 33.48 A
ATOM 1610 CDl ILE 590 58.813 91.513 -4.018 1.00 33.48 A
ATOM 1611 C ILE 590 56.661 89.403 -7.964 1.00 33.48 A
ATOM 1612 O ILE 590 57.153 88.520 -8.659 1.00 33.48 A
ATOM 1613 N MET 591 55.404 89.367 -7.550 1.00 33.48 A
ATOM 1614 CA MET 591 54.552 88.263 -7.929 1.00 33.48 A
ATOM 1615 CB MET 591 53.091 88.578 -7.586 1.00 33.48 A
ATOM 1616 CG MET 591 52.762 88.477 -6.087 1.00 33.48 A
ATOM 1617 SD MET 591 51.184 89.244 -5.528 1.00 33.48 A
ATOM 1618 CE MET 591 50.224 88.881 -6.859 1.00 33.48 A
ATOM 1619 C MET 591 54.741 88.035 -9.419 1.00 33.48 A
ATOM 1620 0 MET 591 54.738 86.912 -9.880 1.00 33.48 A
ATOM 1621 N ASN 592 54.956 89.096 -10.174 1.00 33.48 A
ATOM 1622 CA ASN 592 55.140 88.948 -11.612 1.00 33.48 A ATOM 1623 CB ASN 592 54.881 90.,281 -12.305 1.00 33.48 A
ATOM 1624 CG ASN 592 53.441 90. ,674 -12.251 1.00 33.48 A
ATOM 1625 ODl ASN 592 52.671 90. .364 -13.143 1.00 33.48 A
ATOM 1626 ND2 ASN 592 53.060 91. ,336 -11.182 1.00 33.48 A
ATOM 1627 C ASN 592 56.513 88. .419 -12.009 1.00 33.48 A
ATOM 1628 0 ASN 592 56.678 87. .830 -13.083 1.00 33.48 A
ATOM 1629 N HIS 593 57.509 88. .655 -11.164 l. bo 33.48 A
ATOM 1630 CA HIS 593 58.838 88. .149 -11.441 1.00 33.48 A
ATOM 1631 CB HIS 593 59.825 88. .644 -10.394 1.00 33.48 A
ATOM 1632 CG HIS 593 61.088 89. .204 -10.974 1.00 33.48 A
ATOM 1633 CD2 HIS 593 61.314 89. .889 -12.122 1.00 33.48 A
ATOM 1634 NDl HIS 593 62.299 89, .159 -10.309 1.00 33.48 A
ATOM 1635 CEl HIS 593 63.213 89, .797 -11.020 1.00 33.48 A
ATOM 1636 NE2 HIS 593 62.641 90, .252 -12.123 1.00 33.48 A
ATOM 1637 C HIS 593 58.697 86, .633 -11.336 1.00 33.48 A
ATOM 1638 0 HIS 593 59.154 85, .886 -12.186 1.00 33.48 A
ATOM 1639 N CYS 594 58.029 86, .195 -10.281 1.00 33.48 A
ATOM 1640 CA CYS 594 57.813 84, .788 -10.052 1.00 33.48 A
ATOM 1641 CB CYS 594 57.010 84, .597 -8.772 1.00 33.48 A
ATOM 1642 SG CYS 594 57.789 85, .196 -7.283 1.00 33.48 A
ATOM 1643 C CYS 594 57.067 84, .121 -11.199 1.00 33.48 A
ATOM 1644 0 CYS 594 57.277 82. .942 -11.493 1.00 33.48 A
ATOM 1645 N TRP 595 56.188 84. .870 -11.846 1.00 33.48 A
ATOM 1646 CA TRP 595 55.398 84, .303 -12.916 1.00 33.48 A
ATOM 1647 CB TRP 595 53.956 84. .783 -12.818 1.00 33.48 A
ATOM 1648 CG TRP 595 53.301 84. .496 -11.516 1.00 33.48 A
ATOM 1649 CD2 TRP 595 52.352 85. .325 -10.834 1.00 33.48 A
ATOM 1650 CE2 TRP 595 51.961 84, .639 -9.672 1.00 33.48 A
ATOM 1651 CE3 TRP 595 51.795 86, .582 -11.095 1.00 33.48 A
ATOM 1652 CDl TRP 595 53.441 83. .374 -10.760 1.00 33.48 A
ATOM 1653 NEl TRP 595 52.639 83. .449 -9.650 1.00 33.48 A
ATOM 1654 CZ2 TRP 595 51.039 85. .169 -8.772 1.00 33.48 A
ATOM 1655 CZ3 TRP 595 50.881 87, .105 -10.201 1.00 33.48 A
ATOM 1656 CH2 TRP 595 50.513 86. .400 -9.054 1.00 33.48 A
ATOM 1657 C TRP 595 55.911 84, .538 -14.322 1.00 33.48 A
ATOM 1658 0 TRP 595 55.131 84, .565 -15.264 1.00 33.48 A
ATOM 1659 N LYS 596 57.214 84. .709 -14.480 1.00 33.48 A
ATOM 1660 CA LYS 596 57.761 84. .882 -15.814 1.00 33.48 A
ATOM 1661 CB LYS 596 59.221 85. .316 -15.725 1.00 33.48 A
ATOM 1662 CG LYS 596 59.417 86. ,666 -15.050 1.00 33.48 A
ATOM 1663 CD LYS 596 58.861 87. ,796 -15.893 1.00 33.48 A
ATOM 1664 CE LYS 596 58.449 89. ,000 -15.037 1.00 33.48 A
ATOM 1665 NZ LYS 596 57.585 90. ,011 -15.765 1.00 33.48 A
ATOM 1666 C LYS 596 57.637 83. ,532 -16.531 1.00 33.48 A ATOM 1667 0 LYS 596 57.694 82.485 -15, .903 1.00 33.48 A
ATOM 1668 N GLU 597 57.454 83.548 -17, .843 1.00 33 .48 A
ATOM 1669 CA GLU 597 57.312 82.308 -18, .602 1.00 33 .48 A
ATOM 1670 CB GLU 597 57.093 82.634 -20, .081 1.00 33 .48 A
ATOM 1671 CG GLU 597 56.469 81.525 -20, .917 1.00 33 .48 A
ATOM 1672 CD GLU 597 56.425 81.891 -22, .409 1.00 33 .48 A
ATOM 1673 OEl GLU 597 57.507 81.947 -23, .052 1.00 33 .48 A
ATOM 1674 OE2 GLU 597 55.311 82.137 -22, .942 1.00 33 .48 A
ATOM 1675 C GLU 597 58.516 81.367 -18. .452 1.00 33, .48 A
ATOM 1676 0 GLU 597 58.359 80.199 -18, .094 1.00 33, .48 A
ATOM 1677 N ARG 598 59.715 81.873 -18, .722 1.00 33 .48 A
ATOM 1678 CA ARG 598 60.924 81.061 -18, .620 1.00 33 .48 A
ATOM 1679 CB ARG 598 62.083 81.674 -19, .411 1.00 33, .48 A
ATOM 1680 CG ARG 598 61.832 81.959 -20, .860 1.00 33 .48 A
ATOM 1681 CD ARG 598 63.142 82.024 -21, .631 1.00 33 .48 A
ATOM 1682 NE ARG 598 63.274 80.862 -22, .511 1.00 33, .48 A
ATOM 1683 CZ ARG 598 64.042 80.829 -23. .596 1.00 33, .48 A
ATOM 1684 NHl ARG 598 64.754 81.899 -23. .933 1.00 33, .48 A
ATOM 1685 NH2 ARG 598 64.080 79.738 -24. ,356 1.00 33, .48 A
ATOM 1686 C ARG 598 61.407 80.908 -17. .195 1.00 33, .48 A
ATOM 1687 0 ARG 598 61.657 81.893 -16, .509 1.00 33 .48 A
ATOM 1688 N PRO 599 61.574 79.669 -16, .737 1.00 33, .48 A
ATOM 1689 CD PRO 599 61.329 78.374 -17, .388 1.00 33, .48 A
ATOM 1690 CA PRO 599 62.050 79.480 -15. .371 1.00 33 .48 A
ATOM 1691 CB PRO 599 62.366 77.992 -15. .328 1.00 33, .48 A
ATOM 1692 CG PRO 599 61.326 77.426 -16. .206 1.00 33, .48 A
ATOM 1693 C PRO 599 63.287 80.336 -15, .143 1.00 33, .48 A
ATOM 1694 0 PRO 599 63.479 80.902 -14, .080 1.00 33 .48 A
ATOM 1695 N GLU 600 64.110 80.442 -16. .174 1.00 33, .48 A
ATOM 1696 CA GLU 600 65.344 81.202 -16. ,086 1.00 33, .48 A
ATOM 1697 CB GLU 600 66.209 80.957 -17. .309 1.00 33, .48 A
ATOM 1698 CG GLU 600 65.466 81.094 -18. ,596 1.00 33, .48 A
ATOM 1699 CD GLU 600 66.401 81.219 -19. ,781 1.00 33, .48 A
ATOM 1700 OEl GLU 600 65.903 81.195 -20. ,939 1.00 33, .48 A
ATOM 1701 OE2 GLU 600 67.635 81.349 -19. ,542 1.00 33, .48 A
ATOM 1702 C GLU 600 65.188 82.689 -15. ,905 1.00 33, .48 A
ATOM 1703 0 GLU 600 66.180 83.372 -15. ,668 1.00 33, .48 A
ATOM 1704 N ASP 601 63.963 83.197 -16. ,021 1.00 33. .48 A
ATOM 1705 CA ASP 601 63.734 84.625 -15. ,846 1.00 33, .48 A
ATOM 1706 CB ASP 601 62.772 85.167 -16. ,907 1.00 33, .48 A
ATOM 1707 CG ASP 601 63.347 85.147 -18. ,332 1.00 33, .48 A
ATOM 1708 ODl ASP 601 64.455 85.697 -18. ,588 1.00 33, .48 A
ATOM 1709 OD2 ASP 601 62.648 84.588 -19. ,213 1.00 33, .48 A
ATOM 1710 C ASP 601 63.154 84.910 -14. ,467 1.00 33, .48 A ATOM 1711 0 ASP 601 62.841 86.044 -14.151 1.00 33,.48 A
ATOM 1712 N ARG 602 63.015 83.880 -13.642 1.00 33 .48 A
ATOM 1713 CA ARG 602 62.449 84.039 -12.305 1.00 33, .48 A
ATOM 1714 CB ARG 602 61.489 82.892 -12.004 1.00 33, .48 A
ATOM 1715 CG ARG 602 60.362 82.782 -12.984 1.00 33, .48 A
ATOM 1716 CD ARG 602 59.632 81.485 -12.819 1.00 33, .48 A
ATOM 1717 NE ARG 602 58.985 81.105 -14.063 1.00 33, .48 A
ATOM 1718 CZ ARG 602 58.682 79.858 -14.399 1.00 33, .48 A
ATOM 1719 NH1 ARG 602 58.964 78.862 -13.574 1.00 33 .48 A
ATOM 1720 NH2 ARG 602 58.127 79.608 -15.575 1.00 33, .48 A
ATOM 1721 C ARG 602 63.497 84.106 -11.206 1.00 33, .48 A
ATOM 1722 0 ARG 602 64.496 83.401 -11.244 1.00 33 .48 A
ATOM 1723 N PRO 603 63.260 84.945 -10.191 1.00 33, .48 A
ATOM 1724 CD PRO 603 61.991 85.635 -9.917 1.00 33 .48 A
ATOM 1725 CA PRO 603 64.182 85.110 -9.071 1.00 33 .48 A
ATOM 1726 CB PRO 603 63.494 86.170 -8.231 1.00 33, .48 A
ATOM 1727 CG PRO 603 62.066 85.856 -8.439 1.00 33 .48 A
ATOM 1728 C PRO 603 64.358 83.811 -8.312 1.00 33, .48 A
ATOM 1729 0 PRO 603 63.418 83.029 -8.186 1.00 33 .48 A
ATOM 1730 N ALA 604 65.559 83.560 -7.815 1.00 33, .48 A
ATOM 1731 CA ALA 604 65.777 82.338 -7.049 1.00 33, .48 A
ATOM 1732 CB ALA 604 67.239 82.006 -6.987 1.00 33, .48 A
ATOM 1733 C ALA 604 65.251 82.667 -5.671 1.00 33, .48 A
ATOM 1734 0 ALA 604 65.137 83.844 -5.324 1.00 33, .48 A
ATOM 1735 N PHE 605 64.922 81.656 -4.879 1.00 33, .48 A
ATOM 1736 CA PHE 605 64.405 81.950 -3.555 1.00 33, .48 A
ATOM 1737 CB PHE 605 64.020 80.671 -2.811 1.00 33, .48 A
ATOM 1738 CG PHE 605 62.611 80.236 -3.063 1.00 33, .48 A
ATOM 1739 CDl PHE 605 61.563 81.096 -2.821 1.00 33 .48 A
ATOM 1740 CD2 PHE 605 62.335 78.989 -3.570 1.00 33 .48 A
ATOM 1741 CEl PHE 605 60.268 80.714 -3.087 1.00 33 .48 A
ATOM 1742 CE2 PHE 605 61.039 78.607 -3.834 1.00 33 .48 A
ATOM 1743 CZ PHE 605 60.007 79.471 -3.593 1.00 33 .48 A
ATOM 1744 C PHE 605 65.377 82.765 -2.730 1.00 33 .48 A
ATOM 1745 0 PHE 605 64.993 83.352 -1.728 1.00 33 .48 A
ATOM 1746 N SER 606 66.635 82.823 -3.149 1.00 33 .48 A
ATOM 1747 CA SER 606 67.600 83.603 -2.397 1.00 33 .48 A
ATOM 1748 CB SER 606 69.036 83.139 -2.691 1.00 33 .48 A
ATOM 1749 OG SER 606 69.468 83.467 -3.999 1.00 33 .48 A
ATOM 1750 C SER 606 67.460 85.094 -2.664 1.00 33, .48 A
ATOM 1751 0 SER 606 67.675 85.891 -1.770 1.00 33 .48 A
ATOM 1752 N ALA 607 67.104 85.478 -3.885 1.00 33, .48 A
ATOM 1753 CA ALA 607 66.947 86.898 -4.194 1.00 33, .48 A
ATOM 1754 CB ALA 607 66.982 87.141 -5.717 1.00 33, .48 A ATOM 1755 C ALA " "607 65.628 87.402 -3.602 1.00 33.48 A
ATOM 1756 0 ALA 607 65.596 88.446 -2.935 1.00 33.48 A
ATOM 1757 N LEU 608 64.550 86.652 -3.840 1.00 33.48 A
ATOM 1758 CA LEU 608 63.245 87.005 -3.317 1.00 33.48 A
ATOM 1759 CB LEU 608 62.260 85.859 -3.541 1.00 33.48 A
ATOM 1760 CG LEU 608 61.671 85.716 -4.946 1.00 33.48 A
ATOM 1761 CDl LEU 608 60.994 84.381 -5.074 1.00 33.48 A
ATOM 1762 CD2 LEU 608 60.687 86.830 -5.225 1.00 33.48 A
ATOM 1763 C LEU 608 63.399 87.286 -1.834 1.00 33.48 A
ATOM 1764 O LEU 608 62.892 88.275 -1.310 1.00 33.48 A
ATOM 1765 N LEU 609 64.122 86.414 -1.159 1.00 33.48 A
ATOM 1766 CA LEU 609 64.356 86.578 0.259 1.00 33.48 A
ATOM 1767 CB LEU 609 65.352 85.538 0.742 1.00 33.48 A
ATOM 1768 CG LEU 609 65.319 85.312 2.245 1.00 33.48 A
ATOM 1769 CDl LEU 609 63.986 84.677 2.595 1.00 33.48 A
ATOM 1770 CD2 LEU 609 66.461 84.424 2.675 1.00 33.48 A
ATOM 1771 C LEU 609 64.904 87.974 0.553 1.00 33.48 A
ATOM 1772 O LEU 609 64.474 88.641 1.491 1.00 33.48 A
ATOM 1773 N ARG 610 65.862 88.420 -0.246 1.00 33.48 A
ATOM 1774 CA ARG 610 66.441 89.733 -0.031 1.00 33.48 A
ATOM 1775 CB ARG 610 67.683 89.925 -0.906 1.00 33.48 A
ATOM 1776 CG ARG 610 68.879 89.014 -0.580 1.00 33.48 A
ATOM 1777 CD ARG 610 70.122 89.473 -1.355 1.00 33.48 A
ATOM 1778 NE ARG 610 71.225 88.507 -1.348 1.00 33.48 A
ATOM 1779 CZ ARG 610 71.185 87.299 -1.921 1.00 33.48 A
ATOM 1780 NH1 ARG 610 70.086 86.883 -2.560 1.00 33.48 A
ATOM 1781 NH2 ARG 610 72.250 86.496 -1.856 1.00 33.48 A
ATOM 1782 C ARG 610 65.391 90.775 -0.374 1.00 33.48 A
ATOM 1783 O ARG 610 65.029 91.605 0.464 1.00 33.48 A
ATOM 1784 N GLN 611 64.910 90.716 -1.613 1.00 33.48 A
ATOM 1785 CA GLN 611 63.869 91.618 -2.121 1.00 33.48 A
ATOM 1786 CB GLN 611 63.235 91.013 -3.380 1.00 33.48 A
ATOM 1787 CG GLN 611 63.725 91.633 -4.654 1.00 33.48 A
ATOM 1788 CD GLN 611 63.526 90.738 -5.852 1.00 33.48 A
ATOM 1789 OEl GLN 611 62.443 90.212 -6.068 1.00 33.48 A
ATOM 1790 NE2 GLN 611 64.575 90.568 -6.648 1.00 33.48 A
ATOM 1791 C GLN 611 62.770 91.914 -1.086 1.00 33.48 A
ATOM 1792 O GLN 611 62.536 93.080 -0.740 1.00 33.48 A
ATOM 1793 N LEU 612 62.104 90.855 -0.610 1.00 33.48 A
ATOM 1794 CA LEU 612 61.045 90.979 0.387 1.00 33.48 A
ATOM 1795 CB LEU 612 60.525 89.591 0.791 1.00 33.48 A
ATOM 1796 CG LEU 612 59.773 88.771 -0.267 1.00 33.48 A
ATOM 1797 CDl LEU 612 59.218 87.468 0.320 1.00 33.48 A
ATOM 1798 CD2 LEU 612 58.644 89.613 -0.807 1.00 33.48 A sss
ATOM 1799 C LEU 612 61.528 91.733 1.632 1.00 33.48 A
ATOM 1800 0 LEU 612 60.767 92.467 2.250 1.00 33.48 A
ATOM 1801 N ALA 613 62.795 91.547 1.997 1.00 33.48 A
ATOM 1802 CA ALA 613 63.371 92.224 3.159 1.00 33.48 A
ATOM 1803 CB ALA 613 64.745 91.704 3.415 1.00 33.48 A
ATOM 1804 C ALA 613 63.427 93.724 2.900 1.00 33.48 A
ATOM 1805 O ALA 613 63.060 94.542 3.750 1.00 33.48 A
ATOM 1806 N GLU 614 63.903 94.077 1.713 1.00 33.48 A
ATOM 1807 CA GLU 614 63.976 95.469 1.299 1.00 33.48 A
ATOM 1808 CB GLU 614 64.495 95.566 -0.144 1.00 33.48 A
ATOM 1809 CG GLU 614 65.963 95.200 -0.352 1.00 33.48 A
ATOM 1810 CD GLU 614 66.387 95.270 -1.826 1.00 33.48 A
ATOM 1811 OEl GLU 614 66.291 96.372 -2.420 1.00 33.48 A
ATOM 1812 OE2 GLU 614 66.814 94.226 -2.387 1.00 33.48 A
ATOM 1813 C GLU 614 62.593 96.135 1.354 1.00 33.48 A
ATOM 1814 O GLU 614 62.438 97.253 0.881 1.00 33.48 A
ATOM 1815 N ILE 615 61.590 95.449 1.894 1.00 33.48 A
ATOM 1816 CA ILE 615 60.233 96.006 1.974 1.00 33.48 A
ATOM 1817 CB ILE 615 59.195 95.078 1.279 1.00 33.48 A
ATOM 1818 CG2 ILE 615 57.815 95.371 1.800 1.00 33.48 A
ATOM 1819 CGl ILE 615 59.228 95.275 -0.238 1.00 33.48 A
ATOM 1820 CDl ILE 615 58.298 94.357 -0.980 1.00 33.48 A
ATOM 1821 C ILE 615 59.765 96.268 3.417 1.00 33.48 A
ATOM 1822 O ILE 615 59.320 97.374 3.742 1.00 33.48 A
ATOM 1823 N ALA 616 59.864 95.249 4.269 1.00 33.48 A
ATOM 1824 CA ALA 616 59.463 95.360 5.662 1.00 33.48 A
ATOM 1825 CB ALA 616 59.588 94.016 6.339 1.00 33.48 A
ATOM 1826 C ALA 616 60.284 96.411 6.418 1.00 33.48 A
ATOM 1827 O ALA 616 59.793 97.518 6.674 1.00 33.48 A
ATOM 1828 N GLU 617 61.522 96.070 6.788 1.00 33.48 A
ATOM 1829 CA GLU 617 62.396 97.013 7.510 1.00 33.48 A
ATOM 1830 CB GLU 617 63.828 96.448 7.666 1.00 33.48 A
ATOM 1831 CG GLU 617 64.777 97.332 8.542 1.00 33.48 A
ATOM 1832 CD GLU 617 65.070 96.747 9.941 1.00 33.48 A
ATOM 1833 OEl GLU 617 65.220 97.546 10.907 1.00 33.48 A
ATOM 1834 OE2 GLU 617 65.163 95.493 10.065 1.00 33.48 A
ATOM 1835 C GLU 617 62.434 98.302 6.684 1.00 33.48 A
ATOM 1836 O GLU 617 62.953 99.341 7.118 1.00 33.48 A
ATOM 1837 N SER 618 61.878 98.200 5.477 1.00 33.48 A
ATOM 1838 CA SER 618 61.782 99.317 4.560 1.00 33.48 A
ATOM 1839 CB SER 618 61.619 98.796 3.138 1.00 33.48 A
ATOM 1840 OG SER 618 61.418 99.860 2.225 1.00 33.48 A
ATOM 1841 C SER 618 60.567 100.152 4.970 1.00 33.48 A
ATOM 1842 O SER 618 60.020 99.869 6.065 1.00 33.48 A ATOM 1843 OXT SER 618 60.185 101.077 4.213 1.00 33.48 A
TER 1844 SER 618 A
ATOM 1845 CB SER 361 -49.218 211.791 64.809 1.00 33.48 B
ATOM 1846 OG SER 361 -50.106 212.296 63.815 1.00 33.48 B
ATOM 1847 C SER 361 -47.432 211.425 63.079 1.00 33.48 B
ATOM 1848 0 SER 361 -48.332 210.998 62.352 1.00 33.48 B
ATOM 1849 N SER 361 -47.450 213.513 64.456 1.00 33.48 B
ATOM 1850 CA SER 361 -47.744 212.046 64.446 1.00 33.48 B
ATOM 1851 N GLU 362 -46.145 211.376 62.743 1.00 33.48 B
ATOM 1852 CA GLU 362 -45.687 210.813 61.467 1.00 33.48 B
ATOM 1853 CB GLU 362 -44.391211.511 61.030 1.00 33.48 B
ATOM 1854 CG GLU 362 -44.431 213.018 61.239 1.00 33.48 B
ATOM 1855 CD GLU 362 -43.060 213.600 61.566 1.00 33.48 B
ATOM 1856 OEl GLU 362 -42.985 214.823 61.885 1.00 33.48 B
ATOM 1857 OE2 GLU 362 -42.062 212.831 61.503 1.00 33.48 B
ATOM 1858 C GLU 362 -45.454 209.289 61.565 1.00 33.48 B
ATOM 1859 0 GLU 362 -46.036 208.518 60.793 1.00 33.48 B
ATOM 1860 N LEU 363 -44.610 208.858 62.504 1.00 33.48 B
ATOM 1861 CA LEU 363 -44.330 207.427 62.659 1.00 33 .48 B
ATOM 1862 CB LEU 363 -43.753 207.132 64.058 1.00 33.48 B
ATOM 1863 CG LEU 363 -44.374 207.862 65.259 1.00 33.48 B
ATOM 1864 CDl LEU 363 -44.421 206.950 66.475 1.00 33.48 B
ATOM 1865 CD2 LEU 363 -43.567 209.129 65.550 1.00 33.48 B
ATOM 1866 C LEU 363 -45.560 206.548 62.405 1.00 33.48 B
ATOM 1867 0 LEU 363 -46.690 206.936 62.697 1.00 33 .48 B
ATOM 1868 N THR 364 -45.313 205.360 61.866 1.00 33.48 B
ATOM 1869 CA THR 364 -46.355 204.381 61.530 1.00 33.48 B
ATOM 1870 CB THR 364 -46.064 203.805 60.164 1.00 33.48 B
ATOM 1871 OGl THR 364 -45.727 204.879 59.277 1.00 33.48 B
ATOM 1872 CG2 THR 364 -47.249 203.003 59.656 1.00 33.48 B
ATOM 1873 C THR 364 -46.385 203.191 62.500 1.00 33.48 B
ATOM 1874 0 THR 364 -45.350 202.575 62.744 1.00 33.48 B
ATOM 1875 N PHE 365 -47.549 202.826 63.022 1.00 33.48 B
ATOM 1876 CA PHE 365 -47.583 201.696 63.957 1.00 33.48 B
ATOM 1877 CB PHE 365 -48.566 201.959 65.103 1.00 33.48 B
ATOM 1878 CG PHE 365 -48.209 203.154 65.942 1.00 33.48 B
ATOM 1879 CDl PHE 365 -48.548 203.203 67.285 1.00 33.48 B
ATOM 1880 CD2 PHE 365 -47.546 204.233 65.384 1.00 33.48 B
ATOM 1881 CEl PHE 365 -48.230 204.306 68.054 1.00 33.48 B
ATOM 1882 CE2 PHE 365 -47.227 205.333 66.142 1.00 33.48 B
ATOM 1883 CZ PHE 365 -47.570 205.370 67.484 1.00 33 .48 B
ATOM 1884 C PHE 365 -47.904 200.345 63.323 1.00 33 .48 B
ATOM 1885 0 PHE 365 -49.064 200.002 63.119 1.00 33.48 B
ATOM 1886 N VAL 366 -46.867 199.576 63.021 1.00 33.48 B ATOM 1887 CA VAL 366 -47.062 198,.267 62.,425 1.00 33.48 B
ATOM 1888 CB VAL 366 -45.733 197. .635 62. ,043 1.00 33, .48 B
ATOM 1889 CGl VAL 366 -45.944 196, .178 61. ,634 1.00 33, .48 B
ATOM 1890 CG2 VAL 366 -45.107 198. .443 60. ,945 1.00 33, .48 B
ATOM 1891 C VAL 366 -47.772 197. ,294 63. ,356 1.00 33, .48 B
ATOM 1892 0 VAL 366 -48.864 196. .801 63. ,050 1.00 33 .48 B
ATOM 1893 N GLN 367 -47.137 197. .003 64. ,486 1.00 33, .48 B
ATOM 1894 CA GLN 367 -47.713 196, .079 65. ,450 1.00 33 .48 B
ATOM 1895 CB GLN 367 -47.622 194. .638 64. ,941 1.00 33, .48 B
ATOM 1896 CG GLN 367 -46.226 194. .039 65. ,021 1.00 33 .48 B
ATOM 1897 CD GLN 367 -46.185 192, .590 64. ,555 1.00 33 .48 B
ATOM 1898 OEl GLN 367 -45.117 191, .980 64. ,458 1.00 33 .48 B
ATOM 1899 NE2 GLN 367 -47.353 192, .031 64. ,266 1.00 33 .48 B
ATOM 1900 C GLN 367 -47.002 196, .157 66. ,784 1.00 33 .48 B
ATOM 1901 0 GLN 367 -45.929 196, .755 66. ,906 1.00 33 .48 B
ATOM 1902 N GLU 368 -47.617 195, .538 67. ,785 1.00 33 .48 B
ATOM 1903 CA GLU 368 -47.048 195, .501 69. ,116 1.00 33 .48 B
ATOM 1904 CB GLU 368 -48.131 195, .187 70. .140 1.00 33 .48 B
ATOM 1905 CG GLU 368 -49.437 195, ,878 69. ,868 1.00 33, .48 B
ATOM 1906 CD GLU 368 -50.275 196, .041 71. ,120 1.00 33, .48 B
ATOM 1907 OEl GLU 368 -51.358 196, .674 71. ,029 1.00 33 .48 B
ATOM 1908 OE2 GLU 368 -49.849 195, .534 72. ,190 1.00 33, .48 B
ATOM 1909 C GLU 368 -46.001 194, .397 69. ,135 1.00 33, .48 B
ATOM 1910 0 GLU 368 -45.940 193. .562 68. ,222 1.00 33, .48 B
ATOM 1911 N ILE 369 -45.188 194. .403 70. ,185 1.00 33, .48 B
ATOM 1912 CA ILE 369 -44.135 193, .418 70. ,374 1.00 33, .48 B
ATOM 1913 CB ILE 369 -42.865 193, .816 69. ,655 1.00 33, .48 B
ATOM 1914 CG2 ILE 369 -42.976 193, .480 68. ,178 1.00 33 .48 B
ATOM 1915 CGl ILE 369 -42.604 195, .299 69. ,927 1.00 33, .48 B
ATOM 1916 CDl ILE 369 -41.389 195, .867 69. ,260 1.00 33 .48 B
ATOM 1917 C ILE 369 -43.823 193, .364 71. ,845 1.00 33, .48 B
ATOM 1918 0 ILE 369 -43.120 192, .464 72. ,287 1.00 33, .48 B
ATOM 1919 N GLY 370 -44.342 194, .336 72. .599 1.00 33 .48 B
ATOM 1920 CA GLY 370 -44.089 194, ,368 74. ,035 1.00 33, .48 B
ATOM 1921 C GLY 370 -44.830 195, .409 74. ,869 1.00 33, .48 B
ATOM 1922 0 GLY 370 -45.259 196. .462 74. ,364 1.00 33, .48 B
ATOM 1923 N SER 371 -44.963 195. .112 76. ,163 1.00 33, .48 B
ATOM 1924 CA SER 371 -45.659 195, .984 77. ,113 1.00 33, .48 B
ATOM 1925 CB SER 371 -46.954 195. ,310 77. ,544 1.00 33, .48 B
ATOM 1926 OG SER 371 -46.806 193. ,892 77. ,535 1.00 33, .48 B
ATOM 1927 C SER 371 -44.772 196. ,231 78. ,327 1.00 33, .48 B
ATOM 1928 0 SER 371 -44.371 195. ,287 79. ,011 1.00 33, .48 B
ATOM 1929 N GLY 372 -44.460 197. ,497 78. ,594 1.00 33, .48 B
ATOM 1930 CA GLY 372 -43.590 197. ,825 79. ,717 1.00 33, .48 B ATOM 1931 C GLY 372 -44.306 198.371 80.944 1.00 33.48 B
ATOM 1932 O GLY 372 -45.521 198.195 81.085 1.00 33.48 B
ATOM 1933 N GLN 373 -43.555 199.018 81.838 1.00 33.48 B
ATOM 1934 CA GLN 373 -44.133 199.600 83.052 1.00 33.48 B
ATOM 1935 CB GLN 373 -43.120 199.551 84.213 1.00 33.48 B
ATOM 1936 CG GLN 373 -42.003 200.610 84.125 1.00 33.48 B
ATOM 1937 CD GLN 373 -40.849 200.411 85.133 1.00 33.48 B
ATOM 1938 OEl GLN 373 -39.937 201.249 85.226 1.00 33.48 B
ATOM 1939 NE2 GLN 373 -40.877 199.300 85.871 1.00 33.48 B
ATOM 1940 C GLN 373 -44.526 201.059 82.771 1.00 33.48 B
ATOM 1941 O GLN 373 -45.042 201.748 83.652 1.00 33.48 B
ATOM 1942 N PHE 374 -44.286 201.523 81.545 1.00 33.48 B
ATOM 1943 CA PHE 374 -44.614 202.898 81.178 1.00 33.48 B
ATOM 1944 CB PHE 374 -43.349 203.737 80.982 1.00 33.48 B
ATOM 1945 CG PHE 374 -42.695 204.158 82.253 1.00 33.48 B
ATOM 1946 CDl PHE 374 -41.750 203.351 82.862 1.00 33.48 B
ATOM 1947 CD2 PHE 374 -43.035 205.362 82.851 1.00 33.48 B
ATOM 1948 CEl PHE 374 -41.145 203.737 84.056 1.00 33.48 B
ATOM 1949 CE2 PHE 374 -42.440 205.755 84.042 1.00 33.48 B
ATOM 1950 CZ PHE 374 -41.488 204.937 84.647 1.00 33.48 B
ATOM 1951 C PHE 374 -45.419 203.022 79.904 1.00 33.48 B
ATOM 1952 O PHE 374 -45.553 204.123 79.370 1.00 33.48 B
ATOM 1953 N GLY 375 -45.943 201.912 79.400 1.00 33.48 B
ATOM 1954 CA GLY 375 -46.698 201.986 78.157 1.00 33.48 B
ATOM 1955 C GLY 375 -46.520 200.745 77.296 1.00 33.48 B
ATOM 1956 O GLY 375 -46.709 199.615 77.787 1.00 33.48 B
ATOM 1957 N LEU 376 -46.175 200.920 76.020 1.00 33.48 B
ATOM 1958 CA LEU 376 -46.002 199.747 75.160 1.00 33.48 B
ATOM 1959 CB LEU 376 -47.343 199.323 74.538 1.00 33.48 B
ATOM 1960 CG LEU 376 -48.461 198.854 75.469 1.00 33.48 B
ATOM 1961 CDl LEU 376 -49.075 200.068 76.130 1.00 33.48 B
ATOM 1962 CD2 LEU 376 -49.534 198.093 74.674 1.00 33.48 B
ATOM 1963 C LEU 376 -44.971 199.889 74.048 1.00 33.48 B
ATOM 1964 O LEU 376 -44.533 200.988 73.709 1.00 33.48 B
ATOM 1965 N VAL 377 -44.591 198.756 73.474 1.00 33.48 B
ATOM 1966 CA VAL 377 -43.612 198.771 72.405 1.00 33.48 B
ATOM 1967 CB VAL 377 -42.328 197.985 72.786 1.00 33.48 B
ATOM 1968 CGl VAL 377 -41.276 198.176 71.695 1.00 33.48 B
ATOM 1969 CG2 VAL 377 -41.796 198.457 74.131 1.00 33.48 B
ATOM 1970 C VAL 377 -44.175 198.170 71.130 1.00 33.48 B
ATOM 1971 O VAL 377 -44.579 197.003 71.099 1.00 33.48 B
ATOM 1972 N HIS 378 -44.201 198.983 70.083 1.00 33.48 B
ATOM 1973 CA HIS 378 -44.692 198.540 68.795 1.00 33.48 B
ATOM 1974 CB HIS 378 -45.854 199.392 68.311 1.00 33.48 B ATOM 1975 CG HIS 378 -47.133 199.152 69.037 1.00 33.48 B
ATOM 1976 CD2 HIS 378 -48.208 198.397 68.714 1.00 33.48 B
ATOM 1977 NDl HIS 378 -47.430 199.752 70.244 1.00 33.48 B
ATOM 1978 CEl HIS 378 -48.637 199.375 70.633 1.00 33.48 B
ATOM 1979 NE2 HIS 378 -49.131198.552 69.723 1.00 33.48 B
ATOM 1980 C HIS 378 -43.599 198.703 67.782 1.00 33.48 B
ATOM 1981 0 HIS 378 -42.717 199.546 67.943 1.00 33.48 B
ATOM 1982 N LEU 379 -43.658 197.895 66.735 1.00 33.48 B
ATOM 1983 CA LEU 379 -42.699 198.022 65.661 1.00 33.48 B
ATOM 1984 CB LEU 379 -42.667 196.755 64.819 1.00 33.48 B
ATOM 1985 CG LEU 379 -41.721 196.785 63.622 1.00 33 .48 B
ATOM 1986 CDl LEU 379 -40.286 196.956 64.072 1.00 33.48 B
ATOM 1987 CD2 LEU 379 -41.875 195.485 62.870 1. 00 33.48 B
ATOM 1988 C LEU 379 -43.332 199.159 64.873 1.00 33.48 B
ATOM 1989 O LEU 379 -44.557 199.327 64.903 1.00 33.48 B
ATOM 1990 N GLY 380 -42.525 199.950 64.178 1.00 33.48 B
ATOM 1991 CA GLY 380 -43.110 201.052 63.432 1.00 33.48 B
ATOM 1992 C GLY 380 -42.173 201.711 62.445 1.00 33.48 B
ATOM 1993 O GLY 380 -40.982 201.900 62.718 1.00 33.48 B
ATOM 1994 N TYR 381 -42.710 202.075 61.288 1.00 33.48 B
ATOM 1995 CA TYR 381 -41.879 202.704 60.283 1. 00 33.48 B
ATOM 1996 CB TYR 381 -42.392 202.326 58.900 1. 00 33.48 B
ATOM 1997 CG TYR 381 -42.731200.852 58.781 1.00 33.48 B
ATOM 1998 CDl TYR 381 -41.959 199.885 59.407 1.00 33.48 B
ATOM 1999 CEl TYR 381 -42.259 198.533 59.292 1.00 33.48 B
ATOM 2000 CD2 TYR 381 -43.821200.425 58.027 1.00 33.48 B
ATOM 2001 CE2 TYR 381 -44.128 199.083 57.906 1.00 33.48 B
ATOM 2002 CZ TYR 381 -43.347 198.139 58.542 1.00 33.48 B
ATOM 2003 OH TYR 381 -43.679 196.796 58.450 1.00 33 .48 B
ATOM 2004 C TYR 381 -41.848 204.220 60.480 1. 00 33.48 B
ATOM 2005 0 TYR 381 -42.848 204.825 60.898 1.00 33.48 B
ATOM 2006 N TRP 382 -40.699 204.827 60.183 1.00 33.48 B
ATOM 2007 CA TRP 382 -40.534 206.271 60.336 1.00 33.48 B
ATOM 2008 CB TRP 382 -39.854 206.569 61.680 1.00 33.48 B
ATOM 2009 CG TRP 382 -39.571208.022 61.926 1.00 33.48 B
ATOM 2010 CD2 TRP 382 -38.300 208.603 62.263 1.00 33.48 B
ATOM 2011 CE2 TRP 382 -38.499 209.993 62.407 1.00 33.48 B
ATOM 2012 CE3 TRP 382 -37.017 208.081 62.458 1.00 33.48 B
ATOM 2013 CDl TRP 382 -40.465 209.056 61.879 1.00 33 .48 B
ATOM 2014 NEl TRP 382 -39.826 210.245 62.169 1.00 33.48 B
ATOM 2015 CZ2 TRP 382 -37.460210.865 62.737 1.00 33.48 B
ATOM 2016 CZ3 TRP 382 -35.988 208.951 62.785 1.00 33.48 B
ATOM 2017 CH2 TRP 382 -36.218 210.325 62.921 1.00 33.48 B
ATOM 2018 C TRP 382 -39.798 207.015 59.200 1.00 33.48 B ATOM 2019 O TRP 382 -40.392 207.259 58.144 1.00 33 .48 B
ATOM 2020 N LEU 383 -38.517 207.352 59.406 1.00 33 .48 B
ATOM 2021 CA LEU 383 -37.739 208.136 58.425 1.00 33 .48 B
ATOM 2022 CB LEU 383 -36.295 208.289 58.903 1.00 33 .48 B
ATOM 2023 CG LEU 383 -35.537 209.476 58.293 1.00 33 .48 B
ATOM 2024 CDl LEU 383 -35.767 210.712 59.183 1.00 33 .48 B
ATOM 2025 CD2 LEU 383 -34.042 209.160 58.208 1.00 33 .48 B
ATOM 2026 C LEU 383 -37.717 207.642 56.979 1.00 33 .48 B
ATOM 2027 O LEU 383 -38.710 207.755 56.250 1.00 33 .48 B
ATOM 2028 N ASN 384 -36.553 207.156 56.553 1.00 33 .48 B
ATOM 2029 CA ASN 384 -36.383 206.596 55.215 1.00 33 .48 B
ATOM 2030 CB ASN 384 -34.913 206.266 54.987 1.00 33 .48 B
ATOM 2031 CG ASN 384 -33.983 207.288 55.632 1.00 33 .48 B
ATOM 2032 ODl ASN 384 -34.047 208.485 55.321 1.00 33 .48 B
ATOM 2033 ND2 ASN 384 -33.119 206.826 56.540 1.00 33 .48 B
ATOM 2034 C ASN 384 -37.173 205.307 55.360 1.00 33 .48 B
ATOM 2035 O ASN 384 -36.663 204.218 55.100 1.00 33 .48 B
ATOM 2036 N LYS 385 -38.421205.455 55.802 1.00 33 .48 B
ATOM 2037 CA LYS 385 -39.300 204.334 56.077 1.00 33 .48 B
ATOM 2038 CB LYS 385 -39.852 203.764 54.774 1.00 33 .48 B
ATOM 2039 CG LYS 385 -40.990 204.625 54.192 1.00 33 .48 B
ATOM 2040 CD LYS 385 -42.146 204.793 55.181 1.00 33 .48 B
ATOM 2041 CE LYS 385 -43.429 205.261 54.482 1.00 33 .48 B
ATOM 2042 NZ LYS 385 -44.647 205.297 55.373 1.00 33 .48 B
ATOM 2043 C LYS 385 -38.479 203.312 56.862 1.00 33 .48 B
ATOM 2044 0 LYS 385 -38.552 202.100 56.644 1.00 33 .48 B
ATOM 2045 N ASP 386 -37.698 203.842 57.797 1.00 33 .48 B
ATOM 2046 CA ASP 386 -36.827 203.043 58.632 1.00 33 .48 B
ATOM 2047 CB ASP 386 -35.664 203.902 59.077 1.00 33 .48 B
ATOM 2048 CG ASP 386 -35.110 204.732 57.942 1.00 33 .48 B
ATOM 2049 ODl ASP 386 -34.409 204.166 57.069 1.00 33 .48 B
ATOM 2050 OD2 ASP 386 -35.393 205.948 57.918 1.00 33 .48 B
ATOM 2051 C ASP 386 -37.550 202.469 59.839 1.00 33 .48 B
ATOM 2052 0 ASP 386 -38.456 203.096 60.401 1.00 33 .48 B
ATOM 2053 N ALA 387 -37.125 201.270 60.232 1.00 33 .48 B
ATOM 2054 CA ALA 387 -37.726 200.558 61.346 1.00 33 .48 B
ATOM 2055 CB ALA 387 -37.302 199.102 61.293 1.00 33 .48 B
ATOM 2056 C ALA 387 -37.359 201.178 62.691 1.00 33 .48 B
ATOM 2057 0 ALA 387 -36.203 201.575 62.909 1.00 33 .48 B
ATOM 2058 N VAL 388 -38.351201.270 63.584 1.00 33 .48 B
ATOM 2059 CA VAL 388 -38.146 201.830 64.925 1.00 33 .48 B
ATOM 2060 CB VAL 388 -38.374 203.354 64.959 1.00 33 .48 B
ATOM 2061 CGl VAL 388 -37.344 204.056 64.114 1.00 33 .48 B
ATOM 2062 CG2 VAL 388 -39.753 203.677 64.478 1.00 33 .48 B ATOM 2063 C VAL 388 -39.051201.216 65.995 1.00 33.48 B
ATOM 2064 0 VAL 388 -39.938 200.393 65.704 1.00 33.48 B
ATOM 2065 N ALA 389 -38.815 201.618 67.241 1.00 33.48 B
ATOM 2066 CA ALA 389 -39.617 201.128 68.354 1.00 33.48 B
ATOM 2067 CB ALA 389 -38.738 200.501 69.390 1.00 33.48 B
ATOM 2068 C ALA 389 -40.404 202.273 68.971 1.00 33.48 B
ATOM 2069 0 ALA 389 -39.835 203.313 69.341 1.00 33.48 B
ATOM 2070 N ILE 390 -41.712 202.070 69.088 1.00 33.48 B
ATOM 2071 CA ILE 390 -42.589 203.086 69.638 1.00 33.48 B
ATOM 2072 CB ILE 390 -43.817 203.272 68.732 1.00 33 .48 B
ATOM 2073 CG2 ILE 390 -44.467 204.620 68.999 1.00 33.48 B
ATOM 2074 CGl ILE 390 -43.386 203.235 67.266 1.00 33.48 B
ATOM 2075 CDl ILE 390 -42.532 204.405 66.858 1.00 33.48 B
ATOM 2076 C ILE 390 -43.061202.692 71.029 1.00 33 .48 B
ATOM 2077 0 ILE 390 -43.686201.639 71.203 1.00 33.48 B
ATOM 2078 N LYS 391 -42.761203.537 72.016 1.00 33.48 B
ATOM 2079 CA LYS 391 -43.165 203.272 73.403 1.00 33.48 B
ATOM 2080 CB LYS 391 -41.984 203.492 74.356 1.00 33.48 B
ATOM 2081 CG LYS 391 -41.311202.201 74.835 1.00 33.48 B
ATOM 2082 CD LYS 391 -40.075 202.530 75.666 1.00 33.48 B
ATOM 2083 CE LYS 391 -39.346201.292 76.170 1.00 33.48 B
ATOM 2084 NZ LYS 391 -40.063 200.582 77.279 1.00 33.48 B
ATOM 2085 C LYS 391 -44.385 204.071 73.907 1.00 33.48 B
ATOM 2086 0 LYS 391 -44.383 205.311 73.935 1.00 33.48 B
ATOM 2087 N THR 392 -45.416203.335 74.318 1.00 33.48 B
ATOM 2088 CA THR 392 -46.636203.939 74.826 1.00 33.48 B
ATOM 2089 CB THR 392 -47.843 202.967 74.717 1.00 33 .48 B
ATOM 2090 OGl THR 392 -47.777 202.240 73.480 1.00 33.48 B
ATOM 2091 CG2 THR 392 -49.163 203.754 74.751 1.00 33.48 B
ATOM 2092 C THR 392 -46.455 204.326 76.298 1.00 33 .48 B
ATOM 2093 0 THR 392 -46.428 205.513 76.648 1.00 33.48 B
ATOM 2094 N ALA 406 -35.610 214.427 82.239 1.00 33.48 B
ATOM 2095 CA ALA 406 -35.363 213.089 81.677 1.00 33.48 B
ATOM 2096 CB ALA 406 -36.619212.189 81.838 1.00 33.48 B
ATOM 2097 C ALA 406 -34.940 213.164 80.206 1.00 33.48 B
ATOM 2098 0 ALA 406 -33.752 212.998 79.887 1.00 33.48 B
ATOM 2099 N ALA 407 -35.910213.401 79.319 00 33.48 B
ATOM 2100 CA ALA 407 -35.617 213.527 77.890 00 33.48 B
ATOM 2101 CB ALA 407 -36.750214.273 77.172 00 33.48 B
ATOM 2102 C ALA 407 -34.313 214.320 77. 770 00 33.48 B
ATOM 2103 0 ALA 407 -33.474214.045 76.912 00 33.48 B
ATOM 2104 N GLU 408 -34.152 215.307 78.648 1.00 33.48 B
ATOM 2105 CA GLU 408 -32.953 216.121 78.647 1.00 33.48 B
ATOM 2106 CB GLU 408 -32.876216.961 79.925 1.00 33.48 B ATOM 2107 CG GLU 408 -32.056 218.239 79. 777 1.00 33.48 B
ATOM 2108 CD GLU 408 -32.947 219.473 79.802 1.00 33.48 B
ATOM 2109 OEl GLU 408 -33.795 219.547 80.734 1.00 33.48 B
ATOM 2110 OE2 GLU 408 -32.801220.361 78.916 1.00 33.48 B
ATOM 2111 C GLU 408 -31.781215.140 78.604 1.00 33.48 B
ATOM 2112 O GLU 408 -31.051215.068 77.611 1.00 33.48 B
ATOM 2113 N VAL 409 -31.636 214.364 79.677 1.00 33.48 B
ATOM 2114 CA VAL 409 -30.561 213.380 79.791 1.00 33.48 B
ATOM 2115 CB VAL 409 -30.623 212.634 81.169 1.00 33.48 B
ATOM 2116 CGl VAL 409 -31.617 213.342 82.106 1.00 33.48 B
ATOM 2117 CG2 VAL 409 -30.994 211.159 80.973 1.00 33.48 B
ATOM 2118 C VAL 409 -30.592 212.353 78.660 1.00 33.48 B
ATOM 2119 0 VAL 409 -29.617 212.200 77.924 1.00 33.48 B
ATOM 2120 N MET 410 -31.717 211.666 78.517 1.00 33.48 B
ATOM 2121 CA MET 410 -31.846 210.665 77.476 1.00 33.48 B
ATOM 2122 CB MET 410 -33.317 210.349 77.232 1.00 33.48 B
ATOM 2123 CG MET 410 -33.553 209.012 76.557 1.00 33.48 B
ATOM 2124 SD MET 410 -35.208 208.366 77.000 1.00 33.48 B
ATOM 2125 CE MET 410 -34.763 206.693 77.660 1.00 33.48 B
ATOM 2126 C MET 410 -31.219 211.239 76.225 1.00 33.48 B
ATOM 2127 0 MET 410 -30.228 210.717 75.714 1.00 33.48 B
ATOM 2128 N MET 411 -31.800 212.336 75.757 1.00 33.48 B
ATOM 2129 CA MET 411 -31.328 213.044 74.580 1.00 33.48 B
ATOM 2130 CB MET 411 -32.163 214.320 74.410 1.00 33.48 B
ATOM 2131 CG MET 411 -33.656 214.011 74.136 1.00 33.48 B
ATOM 2132 SD MET 411 -34.899 215.158 74.843 1.00 33.48 B
ATOM 2133 CE MET 411 -35.456 216.097 73.308 1.00 33.48 B
ATOM 2134 C MET 411 -29.843 213.384 74.712 1.00 33.48 B
ATOM 2135 0 MET 411 -29.028 212.999 73.871 1.00 33.48 B
ATOM 2136 N LYS 412 -29.499 214.094 75.783 1.00 33.48 B
ATOM 2137 CA LYS 412 -28.123 214.508 76.049 1.00 33.48 B
ATOM 2138 CB LYS 412 -28.051 215.275 77.379 1.00 33.48 B
ATOM 2139 CG LYS 412 -26.656 215.811 77.746 1.00 33.48 B
ATOM 2140 CD LYS 412 -26.686 216.604 79.059 1.00 33.48 B
ATOM 2141 CE LYS 412 -25.312 217.155 79.429 1.00 33.48 B
ATOM 2142 NZ LYS 412 -24.787 218.153 78.434 1.00 33.48 B
ATOM 2143 C LYS 412 -27.163 213.331 76.105 1.00 33.48 B
ATOM 2144 0 LYS 412 -25.948 213.519 76.255 1.00 33.48 B
ATOM 2145 N LEU 413 -27.704 212.119 76.003 1.00 33.48 B
ATOM 2146 CA LEU 413 -26.885 210.913 76.050 1.00 33.48 B
ATOM 2147 CB LEU 413 -27.469 209.919 77.056 1.00 33.48 B
ATOM 2148 CG LEU 413 -27.389 210.288 78.545 1.00 33.48 B
ATOM 2149 CDl LEU 413 -28.229 209.300 79.367 1.00 33.48 B
ATOM 2150 CD2 LEU 413 -25.932 210.294 79.000 1.00 33.48 B ATOM 2151 C LEU 413 -26.807 210.265 74.682 1.00 33.48 B
ATOM 2152 0 LEU 413 -27.783 210.248 73.938 1.00 33.48 B
ATOM 2153 N SER 414 -25.637 209.732 74.352 1.00 33.48 B
ATOM 2154 CA SER 414 -25.436209.073 73.072 1.00 33.48 B
ATOM 2155 CB SER 414 -25.434 210.108 71.964 1.00 33.48 B
ATOM 2156 OG SER 414 -24.535 209.714 70.948 1.00 33.48 B
ATOM 2157 C SER 414 -24.138 208.256 73.040 1.00 33.48 B
ATOM 2158 0 SER 414 -23.033 208.799 73.120 1.00 33 .48 B
ATOM 2159 N HIS 415 -24.291206.943 72.896 1.00 33.48 B
ATOM 2160 CA HIS 415 -23.166 206.020 72.887 1.00 33.48 B
ATOM 2161 CB HIS 415 -22.841205.641 74.335 1.00 33 .48 B
ATOM 2162 CG HIS 415 -21.638 204.769 74.484 1.00 33.48 B
ATOM 2163 CD2 HIS 415 -20.389 205.046 74.926 1.00 33.48 B
ATOM 2164 NDl HIS 415 -21.635 203.439 74.132 1.00 33.48 B
ATOM 2165 CEl HIS 415 -20.435 202.933 74.351 1.00 33.48 B
ATOM 2166 NE2 HIS 415 -19.661203.888 74.833 1.00 33 .48 B
ATOM 2167 C HIS 415 -23.578 204.791 72.098 1.00 33.48 B
ATOM 2168 0 HIS 415 -24.746 204.446 72.064 1.00 33.48 B
ATOM 2169 N PRO 416 -22.628 204.107 71.455 1.00 33.48 B
ATOM 2170 CD PRO 416 -21.205 204.419 71.271 1.00 33.48 B
ATOM 2171 CA PRO 416 -22.989 202.919 70.685 1.00 33.48 B
ATOM 2172 CB PRO 416 -21.636 202.413 70.197 1.00 33.48 B
ATOM 2173 CG PRO 416 -20.874 203.646 70.020 1.00 33.48 B
ATOM 2174 C PRO 416 -23.755 201.845 71.464 1.00 33.48 B
ATOM 2175 0 PRO 416 -24.641201.182 70.924 1.00 33 .48 B
ATOM 2176 N LYS 417 -23.433 201.679 72.736 1.00 33.48 B
ATOM 2177 CA LYS 417 -24.093 200.653 73.508 1.00 33.48 B
ATOM 2178 CB LYS 417 -23.076 200.002 74.426 1.00 33 .48 B
ATOM 2179 CG LYS 417 -21.817 199.629 73.682 1.00 33.48 B
ATOM 2180 CD LYS 417 -22.168 199.075 72.306 1.00 33.48 B
ATOM 2181 CE LYS 417 -20.925 198.833 71.473 1.00 33.48 B
ATOM 2182 NZ LYS 417 -19.976 197.885 72.123 1.00 33.48 B
ATOM 2183 C LYS 417 -25.311201.083 74.299 1.00 33.48 B
ATOM 2184 0 LYS 417 -25.663 200.446 75.279 1.00 33.48 B
ATOM 2185 N LEU 418 -25.961202.163 73.879 1.00 33.48 B
ATOM 2186 CA LEU 418 -27.168 202.643 74.558 1.00 33.48 B
ATOM 2187 CB LEU 418 -26.917 203.966 75.289 1.00 33.48 B
ATOM 2188 CG LEU 418 -26.083 203.986 76.568 1.00 33.48 B
ATOM 2189 CDl LEU 418 -24.663 203.635 76.235 1.00 33.48 B
ATOM 2190 CD2 LEU 418 -26.126 205.362 77.193 1.00 33.48 B
ATOM 2191 C LEU 418 -28.278 202.850 73.546 1.00 33.48 B
ATOM 2192 0 LEU 418 -28.083 203.506 72.533 1.00 33.48 B
ATOM 2193 N VAL 419 -29.443 202.288 73.819 1.00 33.48 B
ATOM 2194 CA VAL 419 -30.566 202.436 72.917 1.00 33.48 B ATOM 2195 CB VAL 419 -31.817 201.798 73.510 1.00 33 .48 B
ATOM 2196 CGl VAL 419 -32.961 201.988 72.573 1.00 33 .48 B
ATOM 2197 CG2 VAL 419 -31.583 200.309 73.753 1.00 33 .48 B
ATOM 2198 C VAL 419 -30.791 203.922 72.697 1.00 33 .48 B
ATOM 2199 O VAL 419 -30.985 204.672 73.644 1.00 33 .48 B
ATOM 2200 N GLN 420 -30.741 204.345 71.442 1.00 33 .48 B
ATOM 2201 CA GLN 420 -30.895 205.748 71.090 1.00 33 .48 B
ATOM 2202 CB GLN 420 -30.169 206.014 69.785 1.00 33 .48 B
ATOM 2203 CG GLN 420 -30.213 207.460 69.355 1.00 33 .48 B
ATOM 2204 CD GLN 420 -29.260 208.343 70.144 1.00 33 .48 B
ATOM 2205 OEl GLN 420 -28.054 208.067 70.229 1.00 33 .48 B
ATOM 2206 NE2 GLN 420 -29.789 209.417 70.706 1.00 33 .48 B
ATOM 2207 C GLN 420 -32.319 206.250 70.926 1.00 33 .48 B
ATOM 2208 0 GLN 420 -33.125 205.639 70.213 1.00 33 .48 B
ATOM 2209 N LEU 421 -32.631 207.363 71.587 1.00 33 .48 B
ATOM 2210 CA LEU 421 -33.956 207.968 71.440 1.00 33.48 B
ATOM 2211 CB LEU 421 -34.295 208.883 72.612 1.00 33 .48 B
ATOM 2212 CG LEU 421 -35.573 209.708 72.408 1.00 33 .48 B
ATOM 2213 CDl LEU 421 -36.811 208.824 72.440 1.00 33 .48 B
ATOM 2214 CD2 LEU 421 -35.655 210.750 73.505 1.00 33 .48 B
ATOM 2215 C LEU 421 -33.855 208.810 70.174 1.00 33 .48 B
ATOM 2216 O LEU 421 -33.075 209.779 70.121 1.00 33 .48 B
ATOM 2217 N TYR 422 -34.625 208.441 69.152 1.00 33 .48 B
ATOM 2218 CA TYR 422 -34.573 209.176 67.893 1.00 33 .48 B
ATOM 2219 CB TYR 422 -35.104 208.320 66.754 1.00 33.48 B
ATOM 2220 CG TYR 422 -34.075 207.365 66.193 1.00 33 .48 B
ATOM 2221 CDl TYR 422 -34.409 206.476 65.175 1.00 33 .48 B
ATOM 2222 CEl TYR 422 -33.487 205.618 64.645 1.00 33 .48 B
ATOM 2223 CD2 TYR 422 -32.772 207.362 66.668 1.00 33 .48 B
ATOM 2224 CE2 TYR 422 -31.840 206.505 66.142 1.00 33 .48 B
ATOM 2225 CZ TYR 422 -32.202 205.632 65.126 1.00 33 .48 B
ATOM 2226 OH TYR 422 -31.275 204.767 64.576 1.00 33 .48 B
ATOM 2227 C TYR 422 -35.305 210.510 67.894 1.00 33 .48 B
ATOM 2228 O TYR 422 -34.887 211.442 67.211 1.00 33 .48 B
ATOM 2229 N GLY 423 -36.394 210.589 68.658 1.00 33 .48 B
ATOM 2230 CA GLY 423 -37.164 211.816 68.743 1.00 33 .48 B
ATOM 2231 C GLY 423 -38.350 211.702 69.687 1.00 33 .48 B
ATOM 2232 O GLY 423 -38.505 210.703 70.404 1.00 33 .48 B
ATOM 2233 N VAL 424 -39.193 212.734 69.681 1.00 33.48 B
ATOM 2234 CA VAL 424 -40.372 212.769 70.531 1.00 33 .48 B
ATOM 2235 CB VAL 424 -40.112 213.645 71.753 1.00 33 .48 B
ATOM 2236 CGl VAL 424 -39.832 215.078 71.300 1.00 33 .48 B
ATOM 2237 CG2 VAL 424 -41.281 213.555 72.713 1.00 33 .48 B
ATOM 2238 C VAL 424 -41.572 213.325 69.765 1.00 33 .48 B ATOM 2239 0 VAL 424 -41.398 214.150 68.852 1.00 33.48 B
ATOM 2240 N CYS 425 -42.772 212.866 70.128 1.00 33.48 B
ATOM 2241 CA CYS 425 -44.020 213.298 69.486 1.00 33.48 B
ATOM 2242 CB CYS 425 -44.687 212.091 68.819 1.00 33 .48 B
ATOM 2243 SG CYS 425 -45.215 210.852 70.056 1.00 33 .48 B
ATOM 2244 C CYS 425 -44.987 213.868 70.535 1.00 33.48 B
ATOM 2245 0 CYS 425 -45.434 213.157 71.439 1.00 33 .48 B
ATOM 2246 N LEU 426 -45.344 215.135 70.407 1.00 33 .48 B
ATOM 2247 CA LEU 426 -46.225 215.727 71.398 1.00 33.48 B
ATOM 2248 CB LEU 426 -45.376 216.320 72.520 1.00 33.48 B
ATOM 2249 CG LEU 426 -45.578 215.671 73.890 1.00 33 .48 B
ATOM 2250 CDl LEU 426 -46.400 214.373 73.750 1.00 33 .48 B
ATOM 2251 CD2 LEU 426 -44.204 215.415 74.523 1.00 33 .48 B
ATOM 2252 C LEU 426 -47.181216.782 70.843 1.00 33.48 B
ATOM 2253 0 LEU 426 -48.353 216.836 71.235 1.00 33.48 B
ATOM 2254 N ILE 431 -46.163 209.030 76.744 1.00 33.48 B
ATOM 2255 CA ILE 431 -47.297 208.518 75.975 1.00 33 .48 B
ATOM 2256 CB ILE 431 -48.244 209.672 75.490 1.00 33 .48 B
ATOM 2257 CG2 ILE 431 -47.426210.718 74.674 1.00 33 .48 B
ATOM 2258 CGl ILE 431 -49.366 209.118 74.618 1.00 33.48 B
ATOM 2259 CDl ILE 431 -50.078 210.156 73.792 1.00 33.48 B
ATOM 2260 C ILE 431 -46.750 207.764 74.752 1.00 33.48 B
ATOM 2261 0 ILE 431 -47.208 206.665 74.432 1.00 33 .48 B
ATOM 2262 N CYS 432 -45.756 208.378 74.100 1.00 33.48 B
ATOM 2263 CA CYS 432 -45.143 207.766 72.923 1.00 33.48 B
ATOM 2264 CB CYS 432 -46.003 208.012 71.702 1.00 33 .48 B
ATOM 2265 SG CYS 432 -45.045 207.838 70.223 1.00 33.48 B
ATOM 2266 C CYS 432 -43.725 208.234 72.602 1.00 33 .48 B
ATOM 2267 0 CYS 432 -43.520 209.347 72.101 1.00 33 .48 B
ATOM 2268 N LEU 433 -42.745 207.375 72.875 1.00 33.48 B
ATOM 2269 CA LEU 433 -41.352 207.714 72.583 1.00 33 .48 B
ATOM 2270 CB LEU 433 -40.493 207.542 73.823 1.00 33.48 B
ATOM 2271 CG LEU 433 -40.088 208.912 74.365 1.00 33.48 B
ATOM 2272 CDl LEU 433 -41.350 209.721 74.563 1.00 33 .48 B
ATOM 2273 CD2 LEU 433 -39.291208.788 75.665 1.00 33 .48 B
ATOM 2274 C LEU 433 -40.792 206.878 71.434 1.00 33 .48 B
ATOM 2275 0 LEU 433 -41.148 205.704 71.296 1.00 33 .48 B
ATOM 2276 N VAL 434 -39.911207.470 70.623 1.00 33.48 B
ATOM 2277 CA VAL 434 -39.348 206.757 69.475 1.00 33 .48 B
ATOM 2278 CB VAL 434 -39.563 207.563 68.159 1.00 33 .48 B
ATOM 2279 CGl VAL 434 -38.643 207.040 67.057 1.00 33.48 B
ATOM 2280 CG2 VAL 434 -41.019 207.413 67.699 1.00 33 .48 B
ATOM 2281 C VAL 434 -37.888 206.371 69.604 1.00 33 .48 B
ATOM 2282 0 VAL 434 -36.986 207.225 69.651 1.00 33 .48 B ATOM 2283 N PHE 435 -37.669 205.059 69.650 1,.00 33,.48 B
ATOM 2284 CA PHE 435 -36.321204.513 69.795 1, .00 33, .48 B
ATOM 2285 CB PHE 435 -36.203 203.726 71.107 1, .00 33, .48 B
ATOM 2286 CG PHE 435 -36.316 204.580 72.338 1, .00 33, .48 B
ATOM 2287 CDl PHE 435 -35.234 205.326 72.788 1, .00 33, .48 B
ATOM 2288 CD2 PHE 435 -37.516 204.665 73.026 1, .00 33, .48 B
ATOM 2289 CEl PHE 435 -35.346 206.143 73.903 1. .00 33, .48 B
ATOM 2290 CE2 PHE 435 -37.639 205.479 74.140 1, .00 33, .48 B
ATOM 2291 CZ PHE 435 -36.549 206.220 74.579 1. .00 33, .48 B
ATOM 2292 C PHE 435 -35.903 203.603 68.649 1. .00 33, .48 B
ATOM 2293 O PHE 435 -36.753 202.973 67.992 1. .00 33, .48 B
ATOM 2294 N GLU 436 -34.587 203.554 68.420 1, ,00 33, .48 B
ATOM 2295 CA GLU 436 -33.990 202.697 67.402 1, ,00 33, .48 B
ATOM 2296 CB GLU 436 -32.475 202.789 67.467 1. .00 33, .48 B
ATOM 2297 CG GLU 436 -31.918 202.241 68.753 1. .00 33, .48 B
ATOM 2298 CD GLU 436 -30.449 201.905 68.660 1, .00 33, .48 B
ATOM 2299 OEl GLU 436 -30.070 201.142 67.741 1, .00 33, .48 B
ATOM 2300 OE2 GLU 436 -29.673 202.397 69.511 1, .00 33, .48 B
ATOM 2301 •c GLU 436 -34.409 201.257 67.724 1, .00 33, .48 B
ATOM 2302 O GLU 436 -34.270 200.799 68.853 1, .00 33, .48 B
ATOM 2303 N PHE 437 -34.902 200.537 66.726 1, .00 33, .48 B
ATOM 2304 CA PHE 437 -35.379 199.164 66.929 1, .00 33, ,48 B
ATOM 2305 CB PHE 437 -36.326 198.803 65.778 1, .00 33, .48 B
ATOM 2306 CG PHE 437 -36.699 197.364 65.726 1. .00 33, .48 B
ATOM 2307 CDl PHE 437 -35.891 196.450 65.071 1, ,00 33, .48 B
ATOM 2308 CD2 PHE 437 -37.859 196.918 66.335 1, ,00 33, .48 B
ATOM 2309 CEl PHE 437 -36.235 195.113 65.024 1, ,00 33, .48 B
ATOM 2310 CE2 PHE 437 -38.210 195.588 66.292 1, .00 33, .48 B
ATOM 2311 CZ PHE 437 -37.394 194.684 65.635 1, ,00 33, .48 B
ATOM 2312 C PHE 437 -34.330 198.055 67.117 1, .00 33, .48 B
ATOM 2313 O PHE 437 -33.368 197.943 66.353 1, .00 33, .48 B
ATOM 2314 N MET 438 -34.523 197.234 68.145 1, .00 33, .48 B
ATOM 2315 CA MET 438 -33.603 196.129 68.393 1, ,00 33, .48 B
ATOM 2316 CB MET 438 -33.342 195.974 69.886 1, .00 33, .48 B
ATOM 2317 CG MET 438 -32.816 197.245 70.547 1, .00 33, .48 B
ATOM 2318 SD MET 438 -31.288 197.880 69.826 1, .00 3 .48 B
ATOM 2319 CE MET 438 -30.087 196.806 70.607 1, .00 33, .48 B
ATOM 2320 C MET 438 -34.250 194.866 67.838 1, .00 33 .48 B
ATOM 2321 O MET 438 -35.322 194.458 68.285 1, .00 33, .48 B
ATOM 2322 N GLU 439 -33.605 194.254 66.850 1, .00 33, .48 B
ATOM 2323 CA GLU 439 -34.140 193.056 66.217 1, .00 33, .48 B
ATOM 2324 CB GLU 439 -33.295 192.691 64.995 1, .00 33, .48 B
ATOM 2325 CG GLU 439 -31.903 192.199 65.340 1, .00 33, .48 B
ATOM 2326 CD GLU 439 -31.194 191.565 64.160 1, ,00 33, .48 B ATOM 2327 OEl GLU 439 -31.773 190.638 63.545 1.00 33.48 B
ATOM 2328 OE2 GLU 439 -30.053 191.982 63.861 1.00 33.48 B
ATOM 2329 C GLU 439 -34.285 191.827 67.120 1.00 33.48 B
ATOM 2330 O GLU 439 -35.374 191.274 67.236 1.00 33.48 B
ATOM 2331 N HIS 440 -33.212 191.405 67.773 1.00 33 .48 B
ATOM 2332 CA HIS 440 -33.270 190.212 68.612 1.00 33 .48 B
ATOM 2333 CB HIS 440 -31.854 189.724 68.872 1.00 33 .48 B
ATOM 2334 CG HIS 440 -31.028 189.660 67.634 1.00 33 .48 B
ATOM 2335 CD2 HIS 440 -29.995 190.424 67.214 1.00 33 .48 B
ATOM 2336 NDl HIS 440 -31.302 188.779 66.608 1.00 33 .48 B
ATOM 2337 CEl HIS 440 -30.475 189.005 65.607 1.00 33 .48 B
ATOM 2338 NE2 HIS 440 -29.672 189.999 65.948 1.00 33 .48 B
ATOM 2339 C HIS 440 -34.008 190.352 69.934 1.00 33 .48 B
ATOM 2340 O HIS 440 -34.117 189.389 70.709 1.00 33 .48 B
ATOM 2341 N GLY 441 -34.515 191.545 70.196 1.00 33 .48 B
ATOM 2342 CA GLY 441 -35.223 191.759 71.435 1.00 33 .48 B
ATOM 2343 C GLY 441 -34.254 192.029 72.563 1.00 33 .48 B
ATOM 2344 O GLY 441 -33.156 192.551 72.346 1.00 33.48 B
ATOM 2345 N CYS 442 -34.665 191.645 73.766 1.00 33.48 B
ATOM 2346 CA CYS 442 -33.878 191.840 74.973 1.00 33.48 B
ATOM 2347 CB CYS 442 -34.817 192.245 76.091 1.00 33 .48 B
ATOM 2348 SG CYS 442 -36.317 191.277 75.995 1.00 33 .48 B
ATOM 2349 C CYS 442 -33.077 190.607 75.391 1.00 33 .48 B
ATOM 2350 O CYS 442 -33.481 189.469 75.157 1.00 33 .48 B
ATOM 2351 N LEU 443 -31.944 190.863 76.037 1.00 33 .48 B
ATOM 2352 CA LEU 443 -31.027 189.831 76.494 1.00 33 .48 B
ATOM 2353 CB LEU 443 -29.953 190.481 77.362 1.00 33 .48 B
ATOM 2354 CG LEU 443 -28.652 189.712 77.532 1.00 33 .48 B
ATOM 2355 CDl LEU 443 -28.256 189.076 76.221 1.00 33 .48 B
ATOM 2356 CD2 LEU 443 -27.582 190.661 78.028 1.00 33 .48 B
ATOM 2357 C LEU 443 -31.678 188.666 77.238 1.00 33 .48 B
ATOM 2358 0 LEU 443 -31.717 187.553 76.734 1.00 33 .48 B
ATOM 2359 N SER 444 -32.187 188.917 78.434 1.00 33 .48 B
ATOM 2360 CA SER 444 -32.811 187.858 79.215 1.00 33 .48 B
ATOM 2361 CB SER 444 -33.732 188.464 80.268 1.00 33.48 B
ATOM 2362 OG SER 444 -34.807 189.139 79.654 1.00 33.48 B
ATOM 2363 C SER 444 -33.589 186.849 78.364 1.00 33.48 B
ATOM 2364 0 SER 444 -33.529 185.648 78.611 1.00 33 .48 B
ATOM 2365 N ASP 445 -34.327 187.336 77.371 1.00 33 .48 B
ATOM 2366 CA ASP 445 -35.090 186.450 76.496 1.00 33 .48 B
ATOM 2367 CB ASP 445 -36.137 187.228 75.694 1.00 33 .48 B
ATOM 2368 CG ASP 445 -37.270 187.778 76.555 1.00 33 .48 B
ATOM 2369 ODl ASP 445 -37.633 187.154 77.581 1.00 33 .48 B
ATOM 2370 OD2 ASP 445 -37.820 188.839 76.180 1.00 33 .48 B ATOM 2371 C ASP 445 -34.148 185.754 75.516 1.00 33 .48
ATOM 2372 0 ASP 445 -34.240 184.550 75.293 1.00 33 .48 B
ATOM 2373 N TYR 446 -33.245 186.527 74.923 1.00 33 .48 B
ATOM 2374 CA TYR 446 -32.274 185.999 73.967 1.00 33 .48 B
ATOM 2375 CB TYR 446 -31.295 187.093 73.570 1.00 33 .48 B
ATOM 2376 CG TYR 446 -30.489 186.758 72.348 1.00 33 .48 B
ATOM 2377 CDl TYR 446 -31.100 186.643 71.108 1.00 33 .48 B
ATOM 2378 CEl TYR 446 -30.370 186.359 69.986 1.00 33 .48 B
ATOM 2379 CD2 TYR 446 -29.117 186.573 72.425 1.00 33 .48 B
ATOM 2380 CE2 TYR 446 -28.383 186.281 71.301 1.00 33 .48 B
ATOM 2381 CZ TYR 446 -29.018 186.179 70.090 1.00 33 .48 B
ATOM 2382 OH TYR 446 -28.300 185.905 68.966 1.00 33 .48 B
ATOM 2383 C TYR 446 -31.492 184.832 74.564 1.00 33 .48 B
ATOM 2384 O TYR 446 -31.456 183.740 73.998 1.00 33 .48 B
ATOM 2385 N LEU 447 -30.861 185.083 75.708 1.00 33 .48 B
ATOM 2386 CA LEU 447 -30.076 184.079 76.414 1.00 33 .48 B
ATOM 2387 CB LEU 447 -29.526 184.662 77.720 1.00 33 .48 B
ATOM 2388 CG LEU 447 -28.415 185.711 77.657 1.00 33 .48 B
ATOM 2389 CDl LEU 447 -28.387 186.461 78.954 1.00 33 .48 B
ATOM 2390 CD2 LEU 447 -27.073 185.065 77.396 1.00 33 .48 B
ATOM 2391 C LEU 447 -30.928 182.865 76.740 1.00 33 .48 B
ATOM 2392 O LEU 447 -30.568 181.738 76.410 1.00 33.48 B
ATOM 2393 N ARG 448 -32.054 183.103 77.400 1.00 33 .48 B
ATOM 2394 CA ARG 448 -32.960 182.033 77.790 1.00 33 .48 B
ATOM 2395 CB ARG 448 -34.202 182.616 78.456 1.00 33 .48 B
ATOM 2396 CG ARG 448 -34.418 182.210 79.903 1.00 33 .48 B
ATOM 2397 CD ARG 448 -35.335 183.225 80.585 1.00 33.48 B
ATOM 2398 NE ARG 448 -34.649 184.008 81.617 1.00 33.48 B
ATOM 2399 CZ ARG 448 -34.993 185.248 81.974 1.00 33 .48 B
ATOM 2400 NHl ARG 448 -36.013 185.859 81.372 1.00 33 .48 B
ATOM 2401 NH2 ARG 448 -34.336 185.868 82.953 1.00 33 .48 B
ATOM 2402 C ARG 448 -33.387 181.270 76.565 1.00 33 .48 B
ATOM 2403 O ARG 448 -33.237 180.054 76.479 1.00 33 .48 B
ATOM 2404 N THR 449 -33.919 182.004 75.605 1.00 33 .48 B
ATOM 2405 CA THR 449 -34.398 181.401 74.383 1.00 33 .48 B
ATOM 2406 CB THR 449 -35.421 182.307 73.699 1.00 33 .48 B
ATOM 2407 OGl THR 449 -36.333 182.825 74.681 1.00 33 .48 B
ATOM 2408 CG2 THR 449 -36.204 181.518 72.661 1.00 33 .48 B
ATOM 2409 C THR 449 -33.258 181.153 73.424 1.00 33 .48 B
ATOM 2410 O THR 449 -33.280 181.663 72.311 1.00 33 .48 B
ATOM 2411 N GLN 450 -32.266 180.376 73.861 1.00 33 .48 B
ATOM 2412 CA GLN 450 -31.100 180.057 73.031 1.00 33 .48 B
ATOM 2413 CB GLN 450 -30.581 181.300 72.318 1.00 33 .48 B
ATOM 2414 CG GLN 450 -30.960 181.352 70.861 1.00 33 .48 B ATOM 2415 CD GLN 450 -30.435 182.594 70.206 1.00 33 .48 B
ATOM 2416 OEl GLN 450 -30.710 183.708 70.664 1.00 33 .48 B
ATOM 2417 NE2 GLN 450 -29.662 182.423 69.133 1.00 33 .48 B
ATOM 2418 C GLN 450 -29.954 179.448 73.803 1.00 33 .48 B
ATOM 2419 0 GLN 450 -28.820 179.393 73.317 1.00 33 .48 B
ATOM 2420 N ARG 451 -30.260 178.993 75.006 1.00 33 .48 B
ATOM 2421 CA ARG 451 -29.273 178.382 75.879 1.00 33 .48 B
ATOM 2422 CB ARG 451 -30.004 177.720 77.042 1.00 33 .48 B
ATOM 2423 CG ARG 451 -29.130 177.319 78.192 1.00 33 .48 B
ATOM 2424 CD ARG 451 -30.004 177.103 79.395 1.00 33 .48 B
ATOM 2425 NE ARG 451 -30.756 178.310 79.720 1.00 33 .48 B
ATOM 2426 CZ ARG 451 -31.848 178.322 80.479 1.00 33 .48 B
ATOM 2427 NHl ARG 451 -32.302 177.176 80.982 1.00 33 .48 B
ATOM 2428 NH2 ARG 451 -32.486 179.469 80.737 1.00 33 .48 B
ATOM 2429 C ARG 451 -28.353 177.369 75.179 1.00 33 .48 B
ATOM 2430 0 ARG 451 -28.581 176.979 74.045 1.00 33 .48 B
ATOM 2431 N GLY 452 -27.297 176.961 75.867 1.00 33 .48 B
ATOM 2432 CA GLY 452 -26.370 175.993 75.310 1.00 33 .48 B
ATOM 2433 C GLY 452 -25.769 176.231 73.929 1.00 33 .48 B
ATOM 2434 0 GLY 452 -25.055 175.357 73.421 1.00 33 .48 B
ATOM 2435 N LEU 453 -26.036 177.375 73.304 1.00 33 .48 B
ATOM 2436 CA LEU 453 -25.470 177.639 71.981 1.00 33 .48 B
ATOM 2437 CB LEU 453 -26.536 178.131 71.013 1.00 33 .48 B
ATOM 2438 CG LEU 453 -27.848 177.381 70.848 1.00 33 .48 B
ATOM 2439 CDl LEU 453 -28.794 178.214 69.985 1.00 33 .48 B
ATOM 2440 CD2 LEU 453 -27.580 176.026 70.243 1.00 33 .48 B
ATOM 2441 C LEU 453 -24.433 178.733 72.084 1.00 33 .48 B
ATOM 2442 0 LEU 453 -23.965 179.241 71.069 1.00 33 .48 B
ATOM 2443 N PHE 454 -24.078 179.097 73.311 1.00 33 .48 B
ATOM 2444 CA PHE 454 -23.138 180.183 73.524 1.00 33 .48 B
ATOM 2445 CB PHE 454 -23.670 181.121 74.608 1.00 33 .48 B
ATOM 2446 CG PHE 454 -24.857 181.934 74.192 1.00 33 .48 B
ATOM 2447 CDl PHE 454 -24.736 182.918 73.230 1.00 33 .48 B
ATOM 2448 CD2 PHE 454 -26.078 181.759 74.814 1.00 33 .48 B
ATOM 2449 CEl PHE 454 -25.814 183.720 72.904 1.00 33 .48 B
ATOM 2450 CE2 PHE 454 -27.153 182.552 74.493 1.00 33 .48 B
ATOM 2451 CZ PHE 454 -27.023 183.535 73.540 1.00 33 .48 B
ATOM 2452 C PHE 454 -21.716 179.800 73.890 1.00 33 .48 B
ATOM 2453 0 PHE 454 -21.474 179.001 74.793 1.00 33 .48 B
ATOM 2454 N ALA 455 -20.769 180.397 73.186 1.00 33 .48 B
ATOM 2455 CA ALA 455 -19.375 180.162 73.474 1.00 33 .48 B
ATOM 2456 CB ALA 455 -18.546 180.449 72.245 1.00 33 .48 B
ATOM 2457 C ALA 455 -19.045 181.154 74.588 1.00 33 .48 B
ATOM 2458 0 ALA 455 -19.428 182.328 74.507 1.00 33 .48 B ATOM 2459 N ALA 456 -18.356180.686 75.627 1.00 33 .48 B
ATOM 2460 CA ALA 456 -17.981181.541 76.749 1.00 33 .48 B
ATOM 2461 CB ALA 456 -16.903 180.871 77.574 1.00 33 .48 B
ATOM 2462 C ALA 456 -17.494 182.903 76.270 1.00 33.48 B
ATOM 2463 O ALA 456 -17.921183.947 76.766 1.00 33 .48 B
ATOM 2464 N GLU 457 -16.597 182.883 75.294 1.00 33 .48 B
ATOM 2465 CA GLU 457 -16.030184.107 74.737 1.00 33 .48 B
ATOM 2466 CB GLU 457 -15.205 183.749 73.486 1.00 33 .48 B
ATOM 2467 CG GLU 457 -16.028 183.135 72.335 1.00 33 .48 B
ATOM 2468 CD GLU 457 -15.240182.165 71.445 1.00 33 .48 B
ATOM 2469 OEl GLU 457 -14.010 182.348 71.260 1.00 33 .48 B
ATOM 2470 OE2 GLU 457 -15.864 181.216 70.908 1.00 33 .48 B
ATOM 2471 C GLU 457 -17.125 185.139 74.408 1.00 33 .48 B
ATOM 2472 0 GLU 457 -17.180 186.216 74.993 1.00 33 .48 B
ATOM 2473 N THR 458 -18.008 184.788 73.484 1.00 33 .48 B
ATOM 2474 CA THR 458 -19.084 185.667 73.069 1.00 33 .48 B
ATOM 2475 CB THR 458 -19.972 184.949 72.074 1.00 33 .48 B
ATOM 2476 OGl THR 458 -21.248 184.699 72.664 1.00 33 .48 B
ATOM 2477 CG2 THR 458 -19.349 183.631 71.703 1.00 33 .48 B
ATOM 2478 C THR 458 -19.931186.130 74.253 1.00 33 .48 B
ATOM 2479 0 THR 458 -20.378 187.282 74.308 1.00 33 .48 B
ATOM 2480 N LEU 459 -20.164 185.228 75.198 1.00 33 .48 B
ATOM 2481 CA LEU 459 -20.950 185.570 76.367 1.00 33 .48 B
ATOM 2482 CB LEU 459 -21.104 184.345 77.258 1.00 33 .48 B
ATOM 2483 CG LEU 459 -22.499 184.079 77.822 1.00 33 .48 B
ATOM 2484 CDl LEU 459 -23.565 184.033 76.722 1.00 33 .48 B
ATOM 2485 CD2 LEU 459 -22.439 182.761 78.546 1.00 33 .48 B
ATOM 2486 C LEU 459 -20.217 186.683 77.107 1.00 33 .48 B
ATOM 2487 0 LEU 459 -20.823 187.664 77.527 1.00 33 .48 B
ATOM 2488 N LEU 460 -18.906 186.534 77.259 1.00 33 .48 B
ATOM 2489 CA LEU 460 -18.108 187.546 77.935 1.00 33 .48 B
ATOM 2490 CB LEU 460 -16.638 187.142 77.956 1.00 33 .48 B
ATOM 2491 CG LEU 460 -15.613 188.245 78.230 1.00 33 .48 B
ATOM 2492 CDl LEU 460 -15.699 188.762 79.662 1.00 33 .48 B
ATOM 2493 CD2 LEU 460 -14.251187.674 77.976 1.00 33 .48 B
ATOM 2494 C LEU 460 -18.243 188.861 77.201 1.00 33 .48 B
ATOM 2495 0 LEU 460 -18.290 189.921 77.819 1.00 33 .48 B
ATOM 2496 N GLY 461 -18.311188.777 75.877 1.00 33 .48 B
ATOM 2497 CA GLY 461 -18.423 189.959 75.049 1.00 33 .48 B
ATOM 2498 C GLY 461 -19.663 190.773 75.300 1.00 33 .48 B
ATOM 2499 0 GLY 461 -19.646 191.989 75.144 1.00 33 .48 B
ATOM 2500 N MET 462 -20.748 190.105 75.673 1.00 33 .48 B
ATOM 2501 CA MET 462 -21.999 190.792 75.955 1.00 33.48 B
ATOM 2502 CB MET 462 -23.103 189.780 76.254 1.00 33 .48 B ATOM 2503 CG MET 462 -23.114188.607 75.296 1.00 33 .48 B
ATOM 2504 SD MET 462 -24.569 187.577 75.439 1.00 33 .48 B
ATOM 2505 CE MET 462 -25.271187.790 73.846 1.00 33 .48 B
ATOM 2506 C MET 462 -21.727 191.640 77.180 1.00 33 .48 B
ATOM 2507 O MET 462 -22.185 192.782 77.289 1.00 33 .48 B
ATOM 2508 N CYS 463 -20.954 191.066 78.100 1.00 33 .48 B
ATOM 2509 CA CYS 463 -20.588 191.752 79.330 1.00 33 .48 B
ATOM 2510 CB CYS 463 -19.803 190.818 80.244 1.00 33 .48 B
ATOM 2511 SG CYS 463 -20.902 189.832 81.271 1.00 33 .48 B
ATOM 2512 C CYS 463 -19.797 193.013 79.062 1.00 33 .48 B
ATOM 2513 O CYS 463 -20.005 194.019 79.724 1.00 33 .48 B
ATOM 2514 N LEU 464 -18.885 192.959 78.100 1.00 33.48 B
ATOM 2515 CA LEU 464 -18.110 194.139 77.754 1.00 33 .48 B
ATOM 2516 CB LEU 464 -17.072 193.817 76.689 1.00 33 .48 B
ATOM 2517 CG LEU 464 -15.806 193.186 77.240 1.00 33 .48 B
ATOM 2518 CDl LEU 464 -14.894 192.771 76.100 1.00 33 .48 B
ATOM 2519 CD2 LEU 464 -15.130 194.187 78.166 1.00 33.48 B
ATOM 2520 C LEU 464 -19.068 195.185 77.214 1.00 33.48 B
ATOM 2521 O LEU 464 -19.004 196.356 77.583 1.00 33 .48 B
ATOM 2522 N ASP 465 -19.959 194.747 76.337 1.00 33 .48 B
ATOM 2523 CA ASP 465 -20.928 195.649 75.763 1.00 33 .48 B
ATOM 2524 CB ASP 465 -21.934 194.875 74.920 1.00 33.48 B
ATOM 2525 CG ASP 465 -21.409 194.555 73.549 1.00 33 .48 B
ATOM 2526 ODl ASP 465 -22.162 193.978 72.738 1.00 33 .48 B
ATOM 2527 OD2 ASP 465 -20.238 194.890 73.290 1.00 33 .48 B
ATOM 2528 C ASP 465 -21.645 196.407 76.865 1.00 33 .48 B
ATOM 2529 O ASP 465 -21.602 197.631 76.903 1.00 33 .48 B
ATOM 2530 N VAL 466 -22.289 195.682 77.774 1.00 33.48 B
ATOM 2531 CA VAL 466 -23.009 196.345 78.851 1.00 33 .48 B
ATOM 2532 CB VAL 466 -23.780 195.339 79.738 1.00 33 .48 B
ATOM 2533 CGl VAL 466 -24.189 195.983 81.052 1.00 33 .48 B
ATOM 2534 CG2 VAL 466 -25.022 194.893 79.015 1.00 33 .48 B
ATOM 2535 C VAL 466 -22.082 197.177 79.716 1.00 33.48 B
ATOM 2536 O VAL 466 -22.486 198.187 80.278 1.00 33.48 B
ATOM 2537 N CYS 467 -20.825 196.774 79.802 1.00 33.48 B
ATOM 2538 CA CYS 467 -19.875 197.504 80.616 1.00 33 .48 B
ATOM 2539 CB CYS 467 -18.660 196.631 80.906 1.00 33 .48 B
ATOM 2540 SG CYS 467 -17.616 197.256 82.214 1.00 33 .48 B
ATOM 2541 C CYS 467 -19.434 198.804 79.949 1.00 33 .48 B
ATOM 2542 O CYS 467 -19.283 199.825 80.607 1.00 33 .48 B
ATOM 2543 N GLU 468 -19.232 198.767 78.640 1.00 33 .48 B
ATOM 2544 CA GLU 468 -18.817 199.944 77.900 1.00 33 .48 B
ATOM 2545 CB GLU 468 -18.603 199.591 76.436 1.00 33 .48 B
ATOM 2546 CG GLU 468 -17.423 198.679 76.201 1.00 33 .48 B ATOM 2547 CD GLU 468 -17.300 198.234 74.747 1.00 33 .48 B
ATOM 2548 OEl GLU 468 -17.417 199.104 73.848 1.00 33 .48 B
ATOM 2549 OE2 GLU 468 -17.074 197.021 74.508 1.00 33 .48 B
ATOM 2550 C GLU 468 -19.855 201.053 77.992 1.00 33 .48 B
ATOM 2551 O GLU 468 -19.528 202.235 77.905 1.00 33 .48 B
ATOM 2552 N GLY 469 -21.113 200.672 78.164 1.00 33 .48 B
ATOM 2553 CA GLY 469 -22.170 201.658 78.237 1.00 33 .48 B
ATOM 2554 C GLY 469 -22.377 202.214 79.623 1.00 33 .48 B
ATOM 2555 0 GLY 469 -22.769 203.358 79.777 1.00 33 .48 B
ATOM 2556 N MET 470 -22.137 201.398 80.638 1.00 33.48 B
ATOM 2557 CA MET 470 -22.290 201.842 82.014 1.00 33 .48 B
ATOM 2558 CB MET 470 -22.301200.644 82.966 1.00 33 .48 B
ATOM 2559 CG MET 470 -23.504 199.752 82.866 1.00 33 .48 B
ATOM 2560 SD MET 470 -24.977 200.551 83.435 1.00 33 .48 B
ATOM 2561 CE MET 470 -25.760 200.745 81.893 1.00 33 .48 B
ATOM 2562 C MET 470 -21.099 202.739 82.349 1.00 33 .48 B
ATOM 2563 0 MET 470 -21.093 203.435 83.364 1.00 33 .48 B
ATOM 2564 N ALA 471 -20.073 202.694 81.506 1.00 33 .48 B
ATOM 2565 CA ALA 471 -18.904 203.523 81.723 1.00 33 .48 B
ATOM 2566 CB ALA 471 -17.741203.030 80.895 1.00 33 .48 B
ATOM 2567 C ALA 471 -19.322 204.908 81.274 1.00 33 .48 B
ATOM 2568 O ALA 471 -19.084 205.898 81.963 1.00 33 .48 B
ATOM 2569 N TYR 472 -19.960 204.968 80.115 1.00 33 .48 B
ATOM 2570 CA TYR 472 -20.433 206.230 79.584 1.00 33 .48 B
ATOM 2571 CB TYR 472 -21.160 205.996 78.270 1.00 33 .48 B
ATOM 2572 CG TYR 472 -21.399 207.245 77.472 1.00 33 .48 B
ATOM 2573 CDl TYR 472 -20.353 207.903 76.860 1.00 33 .48 B
ATOM 2574 CEl TYR 472 -20.575 209.055 76.130 1.00 33 .48 B
ATOM 2575 CD2 TYR 472 -22.683 207.774 77.334 1.00 33 .48 B
ATOM 2576 CE2 TYR 472 -22.916 208.924 76.609 1.00 33 .48 B
ATOM 2577 CZ TYR 472 -21.860 209.560 76.009 1.00 33 .48 B
ATOM 2578 OH TYR 472 -22.077 210.708 75.277 1.00 33 .48 B
ATOM 2579 C TYR 472 -21.387 206.809 80.623 1.00 33 .48 B
ATOM 2580 O TYR 472 -21.126 207.864 81.192 1.00 33 .48 B
ATOM 2581 N LEU 473 -22.490 206.123 80.885 1.00 33 .48 B
ATOM 2582 CA LEU 473 -23.422 206.608 81.884 1.00 33 .48 B
ATOM 2583 CB LEU 473 -24.409 205.516 82.270 1.00 33 .48 B
ATOM 2584 CG LEU 473 -25.405 205.120 81.203 1.00 33 .48 B
ATOM 2585 CDl LEU 473 -26.564 204.407 81.850 1.00 33 .48 B
ATOM 2586 CD2 LEU 473 -25.892 206.362 80.494 1.00 33 .48 B
ATOM 2587 C LEU 473 -22.678 207.050 83.140 1.00 33 .48 B
ATOM 2588 O LEU 473 -23.061208.000 83.822 1.00 33 .48 B
ATOM 2589 N GLU 474 -21.598 206.359 83.447 1.00 33 .48 B
ATOM 2590 CA GLU 474 -20.862 206.683 84.644 1.00 33 .48 B ATOM 2591 CB GLU 474 -19.853 205.593 84.959 1.00 33.48 B
ATOM 2592 CG GLU 474 -19.267 205.765 86.321 1.00 33 .48 B
ATOM 2593 CD GLU 474 -18.114 204.859 86.561 1.00 33 .48 B
ATOM 2594 OEl GLU 474 -17.125 204.961 85.794 1.00 33 .48 B
ATOM 2595 OE2 GLU 474 -18.199 204.050 87.515 1.00 33 .48 B
ATOM 2596 C GLU 474 -20.143 208.006 84.548 1.00 33 .48 B
ATOM 2597 0 GLU 474 -20.018 208.726 85.536 1.00 33 .48 B
ATOM 2598 N GLU 475 -19.660 208.313 83.353 1.00 33 .48 B
ATOM 2599 CA GLU 475 -18.927 209.542 83.094 1.00 33 .48 B
ATOM 2600 CB GLU 475 -18.262 209.419 81.740 1.00 33.48 B
ATOM 2601 CG GLU 475 -17.017 210.224 81.544 1.00 33.48 B
ATOM 2602 CD GLU 475 -16.571210.174 80.096 1.00 33.48 B
ATOM 2603 OEl GLU 475 -17.249 210.808 79.246 1.00 33.48 B
ATOM 2604 OE2 GLU 475 -15.563 209.487 79.801 1.00 33.48 B
ATOM 2605 C GLU 475 -19.902 210.712 83.092 1.00 33.48 B
ATOM 2606 0 GLU 475 -19.597 211.806 83.567 1.00 33.48 B
ATOM 2607 N ALA 476 -21.087 210.458 82.553 1.00 33 .48 B
ATOM 2608 CA ALA 476 -22.135 211.462 82.477 1.00 33 .48 B
ATOM 2609 CB ALA 476 -23.128 211.077 81.383 1.00 33 .48 B
ATOM 2610 C ALA 476 -22.856 211.596 83.817 1.00 33 .48 B
ATOM 2611 0 ALA 476 -23.742 212.430 83.978 1.00 33.48 B
ATOM 2612 N CYS 477 -22.463 210.770 84.775 1.00 33.48 B
ATOM 2613 CA CYS 477 -23.064 210.764 86.100 1.00 33.48 B
ATOM 2614 CB CYS 477 -22.731212.043 86.866 1.00 33.48 B
ATOM 2615 SG CYS 477 -21.182 211.915 87.792 1.00 33 .48 B
ATOM 2616 C CYS 477 -24.558 210.546 86.087 1.00 33.48 B
ATOM 2617 0 CYS 477 -25.296 211.163 86.847 1.00 33.48 B
ATOM 2618 N VAL 478 -24.990 209.638 85.224 1.00 33.48 B
ATOM 2619 CA VAL 478 -26.397 209.292 85.117 1.00 33.48 B
ATOM 2620 CB VAL 478 -26.869 209.377 83.654 1.00 33.48 B
ATOM 2621 CGl VAL 478 -28.364 209.096 83.565 1.00 33.48 B
ATOM 2622 CG2 VAL 478 -26.543 210.749 83.096 1.00 33.48 B
ATOM 2623 C VAL 478 -26.587 207.864 85.640 1.00 33.48 B
ATOM 2624 0 VAL 478 -26.160 206.899 85.018 1.00 33.48 B
ATOM 2625 N ILE 479 -27.228 207.735 86.790 1.00 33.48 B
ATOM 2626 CA ILE 479 -27.451206.431 87.388 1.00 33 .48 B
ATOM 2627 CB ILE 479 -27.759 206.568 88.867 1.00 33 .48 B
ATOM 2628 CG2 ILE 479 -27.885 205.205 89.484 1.00 33 .48 B
ATOM 2629 CGl ILE 479 -26.678 207.400 89.549 1.00 33 .48 B
ATOM 2630 CDl ILE 479 -27.007 207.742 90.987 1.00 33 .48 B
ATOM 2631 C ILE 479 -28.589 205.634 86.775 1.00 33 .48 B
ATOM 2632 0 ILE 479 -29.709 206.126 86.656 1.00 33 .48 B
ATOM 2633 N HIS 480 -28.286 204.391 86.406 1.00 33 .48 B
ATOM 2634 CA HIS 480 -29.262 203.455 85.841 1.00 33 .48 B ATOM 2635 CB HIS 480 -28.571202.484 84.879 1.00 33,.48 B
ATOM 2636 CG HIS 480 -29.526 201.648 84.088 1.00 33, .48 B
ATOM 2637 CD2 HIS 480 -29.748 201.570 82.755 1.00 33, .48 B
ATOM 2638 NDl HIS 480 -30.464 200.831 84.681 1.00 33, .48 B
ATOM 2639 CEl HIS 480 -31.227 200.292 83.748 1.00 33, .48 B
ATOM 2640 NE2 HIS 480 -30.814 200.726 82.571 1.00 33, .48 B
ATOM 2641 C HIS 480 -29.754 202.682 87.055 1.00 33, .48 B
ATOM 2642 0 HIS 480 -29.225 201.622 87.366 1.00 33, .48 B
ATOM 2643 N ARG 481 -30.762 203.200 87.740 1.00 33 .48 B
ATOM 2644 CA ARG 481 -31.252 202.572 88.968 1.00 33 .48 B
ATOM 2645 CB ARG 481 -32.277 203.495 89.633 1.00 33 .48 B
ATOM 2646 CG ARG 481 -31.950 204.991 89.504 1.00 33, .48 B
ATOM 2647 CD ARG 481 -33.213 205.843 89.671 1.00 33, .48 B
ATOM 2648 NE ARG 481 -33.516 206.099 91.078 1.00 33, .48 B
ATOM 2649 CZ ARG 481 -32.794 206.911 91.844 1.00 33, .48 B
ATOM 2650 NHl ARG 481 -31.741 207.534 91.328 1.00 33, .48 B
ATOM 2651 NH2 ARG 481 -33.121 207.101 93.115 1.00 33, .48 B
ATOM 2652 C ARG 481 -31.854 201.169 88.856 1.00 33, .48 B
ATOM 2653 0 ARG 481 -32.514 200.713 89.783 1.00 33, .48 B
ATOM 2654 N ASP 482 -31.621 200.474 87.748 1.00 33, .48 B
ATOM 2655 CA ASP 482 -32.190 199.151 87.589 1.00 33, .48 B
ATOM 2656 CB ASP 482 -33.670 199.281 87.247 1.00 33, .48 B
ATOM 2657 CG ASP 482 -34.344 197.938 87.056 1.00 33, .48 B
ATOM 2658 ODl ASP 482 -35.569 197.927 86.769 1.00 33, .48 B
ATOM 2659 OD2 ASP 482 -33.652 196.894 87.192 1.00 33, .48 B
ATOM 2660 C ASP 482 -31.492 198.314 86.532 1.00 33, .48 B
ATOM 2661 0 ASP 482 -32.143 197.662 85.730 1.00 33, .48 B
ATOM 2662 N LEU 483 -30.168 198.304 86.531 1.00 33, .48 B
ATOM 2663 CA LEU 483 -29.450 197.515 85.538 1.00 33, .48 B
ATOM 2664 CB LEU 483 -27.951 197.767 85.671 1.00 33, .48 B
ATOM 2665 CG LEU 483 -27.110 197.582 84.415 1.00 33, .48 B
ATOM 2666 CDl LEU 483 -26.662 196.174 84.296 1.00 33 .48 B
ATOM 2667 CD2 LEU 483 -27.917 197.990 83.214 1.00 33 .48 B
ATOM 2668 C LEU 483 -29.754 196.022 85.690 1.00 33 .48 B
ATOM 2669 0 LEU 483 -29.505 195.434 86.730 1.00 33 .48 B
ATOM 2670 N ALA 484 -30.304 195.419 84.643 1.00 33 .48 B
ATOM 2671 CA ALA 484 -30.644 194.000 84.642 1.00 33 .48 B
ATOM 2672 CB ALA 484 -31.975 193.779 85.353 1.00 3 .48 B
ATOM 2673 C ALA 484 -30.729 193.480 83.206 1.00 33, .48 B
ATOM 2674 0 ALA 484 -30.936 194.246 82.271 1.00 33, .48 B
ATOM 2675 N ALA 485 -30.562 192.174 83.033 1.00 33, .48 B
ATOM 2676 CA ALA 485 -30.635 191.574 81.713 1.00 33, .48 B
ATOM 2677 CB ALA 485 -30.482 190.089 81.822 1.00 33, .48 B
ATOM 2678 C ALA 485 -31.978 191.917 81.095 1.00 33.48 ATOM 2679 O ALA 485 -32.066 192.247 79.922 1.00 33.48 B
ATOM 2680 N ARG 486 -33.032 191.843 81.894 1.00 33 .48 B
ATOM 2681 CA ARG 486 -34.366 192.165 81.404 1.00 33 .48 B
ATOM 2682 CB ARG 486 -35.391 192.080 82.542 1.00 33 .48 B
ATOM 2683 CG ARG 486 -35.018 192.861 83.780 1.00 33 .48 B
ATOM 2684 CD ARG 486 -35.941 192.542 84.947 1.00 33 .48 B
ATOM 2685 NE ARG 486 -35.365 192.986 86.217 1.00 33 .48 B
ATOM 2686 CZ ARG 486 -35.301194.252 86.633 1.00 33 .48 B
ATOM 2687 NHl ARG 486 -35.787 195.247 85.895 1.00 33 .48 B
ATOM 2688 NH2 ARG 486 -34.726 194.522 87.793 1.00 33.48 B
ATOM 2689 C ARG 486 -34.434 193.545 80.761 1.00 33.48 B
ATOM 2690 O ARG 486 -35.265 193.783 79.896 1.00 33 .48 B
ATOM 2691 N ASN 487 -33.549 194.445 81.172 1.00 33 .48 B
ATOM 2692 CA ASN 487 -33.532 195.803 80.639 1.00 33 .48 B
ATOM 2693 CB ASN 487 -33.170 196.788 81.752 1.00 33 .48 B
ATOM 2694 CG ASN 487 -34.349 197.110 82.640 1.00 33 .48 B
ATOM 2695 ODl ASN 487 -35.351 197.665 82.173 1.00 33.48 B
ATOM 2696 ND2 ASN 487 -34.249 196.762 83.924 1.00 33 .48 B
ATOM 2697 C ASN 487 -32.599 196.034 79.456 1.00 33.48 B
ATOM 2698 O ASN 487 -32.587 197.119 78.883 1.00 33.48 B
ATOM 2699 N CYS 488 -31.812 195.037 79.083 1.00 33 .48 B
ATOM 2700 CA CYS 488 -30.897 195.226 77.971 1.00 33.48 B
ATOM 2701 CB CYS 488 -29.539 194.593 78.284 1.00 33 .48 B
ATOM 2702 SG CYS 488 -28.746 195.194 79.807 1.00 33 .48 B
ATOM 2703 C CYS 488 -31.455 194.641 76.687 1.00 33 .48 B
ATOM 2704 O CYS 488 -31.906 193.506 76.652 1.00 33 .48 B
ATOM 2705 N LEU 489 -31.433 195.427 75.627 1.00 33 .48 B
ATOM 2706 CA LEU 489 -31.927 194.958 74.356 1.00 33 .48 B
ATOM 2707 CB LEU 489 -32.662 196.090 73.634 1.00 33 .48 B
ATOM 2708 CG LEU 489 -33.974 196.611 74.251 1.00 33 .48 B
ATOM 2709 CDl LEU 489 -35.008 195.499 74.314 1.00 33 .48 B
ATOM 2710 CD2 LEU 489 -33.721 197.151 75.638 1.00 33 .48 B
ATOM 2711 C LEU 489 -30.738 194.465 73.540 1.00 33 .48 B
ATOM 2712 O LEU 489 -29.613 194.883 73.771 1.00 33 .48 B
ATOM 2713 N VAL 490 -30.994 193.559 72.600 1.00 33 .48 B
ATOM 2714 CA VAL 490 -29.955 192.987 71.748 1.00 33.48 B
ATOM 2715 CB VAL 490 -29.903 191.461 71.898 1.00 33 .48 B
ATOM 2716 CGl VAL 490 -29.146 190.845 70.730 1.00 33 .48 B
ATOM 2717 CG2 VAL 490 -29.242 191.104 73.213 1.00 33.48 B
ATOM 2718 C VAL 490 -30.211 193.301 70.286 1.00 33 .48 B
ATOM 2719 O VAL 490 -31.308 193.053 69.783 1.00 33.48 B
ATOM 2720 N GLY 491 -29.197 193.824 69.601 1.00 33 .48 B
ATOM 2721 CA GLY 491 -29.363 194.172 68.196 1.00 33 .48 B
ATOM 2722 C GLY 491 -28.367 193.589 67.201 1.00 33.48 B ATOM 2723 0 GLY 491 -27.821 192.507 67.418 1.00 33 .48 B
ATOM 2724 N GLU 492 -28.139 194.325 66.110 1.00 33 .48 B
ATOM 2725 CA GLU 492 -27.234 193.933 65.029 1.00 33 .48 B
ATOM 2726 CB GLU 492 -26.831 195.163 64.208 1.00 33.48 B
ATOM 2727 CG GLU 492 -27.818 195.495 63.092 1.00 33.48 B
ATOM 2728 CD GLU 492 -27.433 196.728 62.279 1.00 33 .48 B
ATOM 2729 OEl GLU 492 -26.227 196.893 61.971 1.00 33 .48 B
ATOM 2730 0E2 GLU 492 -28.344 197.523 61.936 1.00 33 .48 B
ATOM 2731 C GLU 492 -25.991 193.171 65.462 1.00 33 .48 B
ATOM 2732 0 GLU 492 -25.233 193.610 66.328 1.00 33 .48 B
ATOM 2733 N ASN 493 -25.794 192.015 64.834 1. 00 33 .48 B
ATOM 2734 CA ASN 493 -24.664 191.147 65.139 1.00 33 .48 B
ATOM 2735 CB ASN 493 -23.377 191.712 64.540 1.00 33 .48 B
ATOM 2736 CG ASN 493 -23.521 192.029 63.058 1.00 33 .48 B
ATOM 2737 ODl ASN 493 -24.084 193.066 62.686 1.00 33 .48 B
ATOM 2738 ND2 ASN 493 -23.030 191.124 62.200 1.00 33 .48 B
ATOM 2739 C ASN 493 -24.531 191.026 66.638 1.00 33 .48 B
ATOM 2740 0 ASN 493 -23.491191.336 67.203 1.00 33 .48 B
ATOM 2741 N GLN 494 -25.612 190.586 67.270 1.00 33 .48 B
ATOM 2742 CA GLN 494 -25.666 190.401 68.714 1.00 33 .48 B
ATOM 2743 CB GLN 494 -24.990 189.084 69.117 1.00 33 .48 B
ATOM 2744 CG GLN 494 -25.797 187.845 68.751 1.00 33 .48 B
ATOM 2745 CD GLN 494 -25.088 186.579 69.144 1.00 33 .48 B
ATOM 2746 OEl GLN 494 -23.902 186.419 68.865 1.00 33 .48 B
ATOM 2747 NE2 GLN 494 -25.802 185.664 69.788 1.00 33 .48 B
ATOM 2748 C GLN 494 -25.112 191.521 69.579 1.00 33 .48 B
ATOM 2749 0 GLN 494 -24.813 191.296 70.748 1.00 33 .48 B
ATOM 2750 N VAL 495 -24.960 192.719 69.030 1.00 33 .48 B
ATOM 2751 CA VAL 495 -24.480 193.817 69.855 1.00 33 .48 B
ATOM 2752 CB VAL 495 -24.488 195.167 69.120 1.00 33 .48 B
ATOM 2753 CGl VAL 495 -24.207 196.293 70.103 1.00 33 .48 B
ATOM 2754 CG2 VAL 495 -23.441 195.166 68.007 1.00 33 .48 B
ATOM 2755 C VAL 495 -25.477 193.923 70.988 1.00 33 .48 B
ATOM 2756 0 VAL 495 -26.635 193.516 70.852 1.00 33 .48 B
ATOM 2757 N ILE 496 -25.028 194.459 72.112 1.00 33 .48 B
ATOM 2758 CA ILE 496 -25.916 194.616 73.240 1.00 33 .48 B
ATOM 2759 CB ILE 496 -25.547 193.625 74.342 1.00 33 .48 B
ATOM 2760 CG2 ILE 496 -26.264 193.954 75.639 1.00 33 .48 B
ATOM 2761 CGl ILE 496 -25.925 192.231 73.858 1.00 33 .48 B
ATOM 2762 CDl ILE 496 -25.790 191.172 74.889 1.00 33.48 B
ATOM 2763 C ILE 496 -25.886 196.052 73.717 1.00 33 .48 B
ATOM 2764 0 ILE 496 -24.823 196.640 73.896 1.00 33 .48 B
ATOM 2765 N LYS 497 -27.068 196.625 73.885 1.00 33 .48 B
ATOM 2766 CA LYS 497 -27.190 197.995 74.327 1.00 33 .48 B ATOM 2767 CB LYS 497 -27.840 198.837 73.226 1.00 33,.48 B
ATOM 2768 CG LYS 497 -27.139 198.738 71.881 1.00 33, .48 B
ATOM 2769 CD LYS 497 -27.838 199.566 70.821 1.00 33, .48 B
ATOM 2770 CE LYS 497 -27.043 199.565 69.520 1.00 33 .48 B
ATOM 2771 NZ LYS 497 -27.453 200.673 68.622 1.00 33, .48 B
ATOM 2772 C LYS 497 -28.026 198.040 75.587 1.00 33, .48 B
ATOM 2773 0 LYS 497 -28.951197.258 75.743 1.00 33 .48 B
ATOM 2774 N VAL 498 -27.694198.942 76.500 1.00 33, .48 B
ATOM 2775 CA VAL 498 -28.460 199.067 77.733 1.00 33, .48 B
ATOM 2776 CB VAL 498 -27.585 199.571 78.935 1.00 33, .48 B
ATOM 2777 CGl VAL 498 -26.396 198.672 79.133 1.00 33 .48 B
ATOM 2778 CG2 VAL 498 -27.131200.994 78.700 1.00 33, .48 B
ATOM 2779 C VAL 498 -29.579 200.072 77.463 1.00 33, .48 B
ATOM 2780 0 VAL 498 -29.591200.726 76.424 1.00 33, .48 B
ATOM 2781 N SER 499 -30.511200.192 78.398 1.00 33, .48 B
ATOM 2782 CA SER 499 -31.619 201.113 78.237 1.00 33, .48 B
ATOM 2783 CB SER 499 -32.520 200.615 77.137 1.00 33, .48 B
ATOM 2784 OG SER 499 -32.934 199.310 77.461 1.00 33 .48 B
ATOM 2785 C SER 499 -32.408 201.185 79.525 1.00 33, .48 B
ATOM 2786 O SER 499 -32.263 200.325 80.384 1.00 33, .48 B
ATOM 2787 N ASP 500 -33.242 202.209 79.652 1.00 33 .48 B
ATOM 2788 CA ASP 500 -34.069 202.398 80.834 1.00 33, .48 B
ATOM 2789 CB ASP 500 -34.602 201.052 81.313 1.00 33, .48 B
ATOM 2790 CG ASP 500 -36.098 201.033 81.386 1.00 33 .48 B
ATOM 2791 ODl ASP 500 -36.707 201.615 80.463 1.00 33 .48 B
ATOM 2792 OD2 ASP 500 -36.664 200.445 82.346 1.00 33, .48 B
ATOM 2793 C ASP 500 -33.317 203.084 81.966 1.00 33, .48 B
ATOM 2794 O ASP 500 -33.608 202.851 83.144 1.00 33 .48 B
ATOM 2795 N PHE 501 -32.368 203.945 81.617 1.00 33, .48 B
ATOM 2796 CA PHE 501 -31.596 204.610 82.643 1.00 33, .48 B
ATOM 2797 CB PHE 501 -30.319 205.223 82.064 1.00 33, .48 B
ATOM 2798 CG PHE 501 -30.200 205.153 80.555 1.00 33, .48 B
ATOM 2799 CDl PHE 501 -29.864 206.290 79.843 1.00 33, .48 B
ATOM 2800 CD2 PHE 501 -30.306 203.952 79.866 1.00 33, .48 B
ATOM 2801 CEl PHE 501 -29.626 206.236 78.487 1.00 33, .48 B
ATOM 2802 CE2 PHE 501 -30.067 203.901 78.508 1.00 33, .48 B
ATOM 2803 CZ PHE 501 -29.724 205.042 77.822 1.00 33 .48 B
ATOM 2804 C PHE 501 -32.361 205.675 83.422 1.00 33 .48 B
ATOM 2805 O PHE 501 -32.631 206.773 82.923 1.00 33 .48 B
ATOM 2806 N GLY 502 -32.722 205.352 84.653 1.00 33 .48 B
ATOM 2807 CA GLY 502 -33.419 206.338 85.450 1.00 33 .48 B
ATOM 2808 C GLY 502 -34.934 206.453 85.336 1.00 33 .48 B
ATOM 2809 0 GLY 502 -35.520 207.302 86.014 1.00 33 .48 B
ATOM 2810 N MET 503 -35.594 205.642 84.511 1.00 33, .48 B ATOM 2811 CA MET 503 -37.047 205.768 84.445 1.00 33.48 B
ATOM 2812 CB MET 503 -37.643 204.862 83.375 1.00 33.48 B
ATOM 2813 CG MET 503 -38.281 205.641 82.251 1.00 33.48 B
ATOM 2814 SD MET 503 -37.000206.527 81.322 1.00 33.48 B
ATOM 2815 CE MET 503 -37.928 207.018 79.800 1.00 33.48 B
ATOM 2816 C MET 503 -37.623 205.398 85.801 1.00 33.48 B
ATOM 2817 0 MET 503 -38.618 205.981 86.251 1.00 33.48 B
ATOM 2818 N THR 504 -36.994 204.419 86.441 1.00 33.48 B
ATOM 2819 CA THR 504 -37.416 203.977 87.757 1.00 33.48 B
ATOM 2820 CB THR 504 -36.317 203.112 88.426 1.00 33.48 B
ATOM 2821 OGl THR 504 -36.562 201.724 88.155 1.00 33.48 B
ATOM 2822 CG2 THR 504 -36.278 203.334 89.932 1.00 33.48 B
ATOM 2823 C THR 504 -37.616 205.248 88.558 1.00 33.48 B
ATOM 2824 0 THR 504 -38.666 205.453 89.177 1.00 33.48 B
ATOM 2825 N ARG 505 -36.606 206.115 88.510 1.00 33.48 B
ATOM 2826 CA ARG 505 -36.630207.391 89.226 1.00 33.48 B
ATOM 2827 CB ARG 505 -35.494 208.303 88.718 1.00 33.48 B
ATOM 2828 CG ARG 505 -35.323 209.597 89.523 1.00 33.48 B
ATOM 2829 CD ARG 505 -34.600 210.686 88.732 1.00 33.48 B
ATOM 2830 NE ARG 505 -35.434 211.882 88.632 1.00 33.48 B
ATOM 2831 CZ ARG 505 -35.221212.869 87.767 1.00 33.48 B
ATOM 2832 NHl ARG 505 -34.188 212.805 86.923 1.00 33.48 B
ATOM 2833 NH2 ARG 505 -36.062 213.902 87.721 1.00 33.48 B
ATOM 2834 C ARG 505 -37.987 208.121 89.103 1.00 33.48 B
ATOM 2835 0 ARG 505 -38.231209.125 89.788 1.00 33.48 B
ATOM 2836 N PHE 506 -38.872 207.622 88.243 1.00 33.48 B
ATOM 2837 CA PHE 506 -40.182 208.237 88.068 1.00 33.48 B
ATOM 2838 CB PHE 506 -40.282 208.861 86.682 1.00 33.48 B
ATOM 2839 CG PHE 506 -39.192 209.828 86.392 1.00 33.48 B
ATOM 2840 CDl PHE 506 -38.819 210.770 87.341 1.00 33.48 B
ATOM 2841 CD2 PHE 506 -38.541209.803 85.167 1.00 33.48 B
ATOM 2842 CEl PHE 506 -37.815 211.669 87.073 1.00 33.48 B
ATOM 2843 CE2 PHE 506 -37.533 210.698 84.883 1.00 33.48 B
ATOM 2844 CZ PHE 506 -37.163 211.637 85.837 1.00 33.48 B
ATOM 2845 C PHE 506 -41.336 207.249 88.263 1.00 33.48 B
ATOM 2846 0 PHE 506 -41.913 206.749 87.287 1.00 33.48 B
ATOM 2847 N PHE 520 -40.815 195.597 94.431 1.00 33.48 B
ATOM 2848 CA PHE 520 -39.448 196.086 94.254 1.00 33.48 B
ATOM 2849 CB PHE 520 -38.962 196.736 95.556 1.00 33.48 B
ATOM 2850 CG PHE 520 -37.553 197.292 95.496 1.00 33.48 B
ATOM 2851 CDl PHE 520 -36.459 196.495 95.817 1.00 33.48 B
ATOM 2852 CD2 PHE 520 -37.332 198.633 95.191 1.00 33.48 B
ATOM 2853 CEl PHE 520 -35.171 197.027 95.843 1.00 33.48 B
ATOM 2854 CE2 PHE 520 -36.046199.173 95.215 1.00 33.48 B ATOM 2855 CZ PHE 520 -34.967 198.370 95.544 1.00 33,.48 B
ATOM 2856 C PHE 520 -38.546 194.928 93.856 1.00 33, .48 B
ATOM 2857 0 PHE 520 -38.813 193.772 94.191 1.00 33, .48 B
ATOM 2858 N PRO 521 -37.470 195.230 93.114 1.00 33, .48 B
ATOM 2859 CD PRO 521 -37.378 196.496 92.365 1.00 33, .48 B
ATOM 2860 CA PRO 521 -36.481 194.258 92.627 1.00 33, .48 B
ATOM 2861 CB PRO 521 -36.262 194.724 91.195 1.00 33, .48 B
ATOM 2862 CG PRO 521 -36.270 196.223 91.355 1.00 33, .48 B
ATOM 2863 C PRO 521 -35.158 194.157 93.432 1.00 33, .48 B
ATOM 2864 0 PRO 521 -34.085 194.473 92.914 1.00 33, .48 B
ATOM 2865 N VAL 522 -35.233 193.687 94.676 1.00 33, .48 B
ATOM 2866 CA VAL 522 -34.043 193.575 95.523 1.00 33, .48 B
ATOM 2867 CB VAL 522 -34.382 193.056 96.952 1.00 33, .48 B
ATOM 2868 CGl VAL 522 -35.352 193.995 97.631 1.00 33, .48 B
ATOM 2869 CG2 VAL 522 -34.972 191.662 96.887 1.00 33. .48 B
ATOM 2870 C VAL 522 -32.953 192.678 94.968 1.00 33. .48 B
ATOM 2871 0 VAL 522 -31.799 192.802 95.360 1.00 33. .48 B
ATOM 2872 N LYS 523 -33.311191.777 94.059 1.00 33, .48 B
ATOM 2873 CA LYS 523 -32.336 190.846 93.494 1.00 33, .48 B
ATOM 2874 CB LYS 523 -33.032 189.872 92.548 1.00 33, .48 B
ATOM 2875 CG LYS 523 -33.857 188.824 93.272 1.00 33, .48 B
ATOM 2876 CD LYS 523 -34.576 187.900 92.294 1.00 33, .48 B
ATOM 2877 CE LYS 523 -35.345 186.801 93.017 1.00 33, .48 B
ATOM 2878 NZ LYS 523 -35.884 185.803 92.056 1.00 33, .48 B
ATOM 2879 C LYS 523 -31.160 191.521 92.793 1.00 33, .48 B
ATOM 2880 0 LYS 523 -30.012 191.086 92.903 1.00 33, .48 B
ATOM 2881 N TRP 524 -31.439 192.591 92.076 1.00 33, .48 B
ATOM 2882 CA TRP 524 -30.377 193.303 91.402 1.00 33, .48 B
ATOM 2883 CB TRP 524 -30.864 193.788 90.043 1.00 33, .48 B
ATOM 2884 CG TRP 524 -31.098 192.683 89.088 1.00 33. ,48 B
ATOM 2885 CD2 TRP 524 -32.317 191.967 88.894 1.00 33, .48 B
ATOM 2886 CE2 TRP 524 -32.063 190.968 87.944 1.00 33, .48 B
ATOM 2887 CE3 TRP 524 -33.599 192.072 89.434 1.00 33, .48 B
ATOM 2888 CDl TRP 524 -30.185 192.114 88.271 1.00 33, .48 B
ATOM 2889 NEl TRP 524 -30.751 191.081 87.575 1.00 33, .48 B
ATOM 2890 CZ2 TRP 524 -33.038 190.081 87.523 1.00 33, .48 B
ATOM 2891 CZ3 TRP 524 -34.563 191.194 89.015 1.00 33, .48 B
ATOM 2892 CH2 TRP 524 -34.280 190.211 88.071 1.00 33, .48 B
ATOM 2893 C TRP 524 -29.968 194.481 92.264 1.00 33, .48 B
ATOM 2894 0 TRP 524 -28.946 195.099 92.031 1.00 33, .48 B
ATOM 2895 N ALA 525 -30.771194.779 93.274 1.00 33, .48 B
ATOM 2896 CA ALA 525 -30.498 195.899 94.162 1.00 33, .48 B
ATOM 2897 CB ALA 525 -31.742 196.229 94.980 1.00 33, .48 B
ATOM 2898 C ALA 525 -29.333 195.630 95.092 1.00 33, .48 B ATOM 2899 O ALA 525 -29.239 194.553 95.669 1.00 33.48 B
ATOM 2900 N SER 526 -28.439 196. 607 95.226 1.00 33.48 B
ATOM 2901 CA SER 526 -27.299 196. 468 96.116 1.00 33.48 B
ATOM 2902 CB SER 526 -26.262 197. 537 95.839 1.00 33.48 B
ATOM 2903 OG SER 526 -26.716 198. 786 96.306 1.00 33.48 B
ATOM 2904 C SER 526 -27.881196. 682 97.489 1.00 33.48 B
ATOM 2905 O SER 526 -28.946197. 262 97.627 1.00 33.48 B
ATOM 2906 N PRO 527 -27.187 196. 223 98.529 1.00 33.48 B
ATOM 2907 CD PRO 527 -25.849 195. 625 98.503 1.00 33.48 B
ATOM 2908 CA PRO 527 -27.663 196. 368 99.902 1.00 33.48 B
ATOM 2909 CB PRO 527 -26.568 195. 692 100.716 1.00 33.48 B
ATOM 2910 CG PRO 527 -25.369 195. 894 99.892 1.00 33.48 B
ATOM 2911 C PRO 527 -27.943 197. 792 100.331 1.00 33.48 B
ATOM 2912 O PRO 527 -28.977 198. 054 100.940 1.00 33.48 B
ATOM 2913 N GLU 528 -27.042 198. 716 100.002 1.00 33.48 B
ATOM 2914 CA GLU 528 -27.238 200. 115 100.369 1.00 33 .48 B
ATOM 2915 CB GLU 528 -26.018 200. 970 100.011 1.00 33.48 B
ATOM 2916 CG GLU 528 -25.698 201. 086 98.529 1.00 33.48 B
ATOM 2917 CD GLU 528 -24.876 199. 933 98.011 1.00 33.48 B
ATOM 2918 OEl GLU 528 -24. 593 199. 006 98.794 1.00 33 .48 B
ATOM 2919 OE2 GLU 528 -24.515 199. 953 96.820 1.00 33.48 B
ATOM 2920 C GLU 528 -28.479 200. 716 99.726 1.00 33.48 B
ATOM 2921 O GLU 528 -28.857 201. 830 100.059 1.00 33.48 B
ATOM 2922 N VAL 529 -29.105 200. 012 98.785 1.00 33.48 B
ATOM 2923 CA VAL 529 -30.333 200. 545 98.214 1.00 33.48 B
ATOM 2924 CB VAL 529 -30.368 200. 555 96.658 1.00 33.48 B
ATOM 2925 CGl VAL 529 -28.998 200. 794 96.104 1.00 33.48 B
ATOM 2926 CG2 VAL 529 -30.971199. 308 96.141 1.00 33.48 B
ATOM 2927 C VAL 529 -31.515 199. 745 98.754 1.00 33.48 B
ATOM 2928 O VAL 529 -32.509 200. 332 99.159 1.00 33.48 B
ATOM 2929 N PHE 530 -31.432 198. 421 98.815 1.00 33 .48 B
ATOM 2930 CA PHE 530 -32. 594 197. 713 99.345 1.00 33.48 B
ATOM 2931 CB PHE 530 -32.524196. 181 99.115 1.00 33.48 B
ATOM 2932 CG PHE 530 -31.551195. 439 99.995 1.00 33.48 B
ATOM 2933 CDl PHE 530 -31.654 195. 466101.371 1.00 33.48 B
ATOM 2934 CD2 PHE 530 -30.579 194. 630 99.431 1.00 33.48 B
ATOM 2935 CEl PHE 530 -30.808 194.696 102.163 1.00 33.48 B
ATOM 2936 CE2 PHE 530 -29.741193.864 100.220 1.00 33.48 B
ATOM 2937 CZ PHE 530 -29.859 193.899 101.583 1.00 33.48 B
ATOM 2938 C PHE 530 -32.795 198.067 100.816 1.00 33.48 B
ATOM 2939 O PHE 530 -33.756 197. 631 101.445 1.00 33.48 B
ATOM 2940 N SER 531 -31.892 198.887 101.349 1.00 33.48 B
ATOM 2941 CA SER 531 -31.993 199.334 102.734 1.00 33.48 B
ATOM 2942 CB SER 531 -30.712 199.021103.496 1.00 33.48 B ATOM 2943 OG SER 531 -30.554 197.622 103.668 1.00 33 .48 B
ATOM 2944 C SER 531 -32.279 200 .830 102. ,830 1.00 33 .48 B
ATOM 2945 O SER 531 -33.337 201 .241 103. 298 1.00 33 .48 B
ATOM 2946 N PHE 532 -31.341201 .647 102. ,372 1.00 33 .48 B
ATOM 2947 CA PHE 532 -31.505 203 .091 102. 442 1.00 33 .48 B
ATOM 2948 CB PHE 532 -30.233 203 .726 102. ,990 1.00 33 .48 B
ATOM 2949 CG PHE 532 -29.590 202 .938 104. 082 1.00 33 .48 B
ATOM 2950 CDl PHE 532 -30.306202 .570 105. ,205 1.00 33 .48 B
ATOM 2951 CD2 PHE 532 -28.265 202 .574 103. ,996 1.00 33 .48 B
ATOM 2952 CEl PHE 532 -29.712 201 .859 106. ,214 1.00 33 .48 B
ATOM 2953 CE2 PHE 532 -27.675 201 .864 105. ,004 1.00 33 .48 B
ATOM 2954 CZ PHE 532 -28.401201 .508 106. ,111 1.00 33 .48 B
ATOM 2955 C PHE 532 -31.782 203 .647 101. ,062 1.00 33 .48 B
ATOM 2956 0 PHE 532 -31.825 204 .867 100. ,861 1.00 33 .48 B
ATOM 2957 N SER 533 -31.973 202 .751 100. ,108 1.00 33 .48 B
ATOM 2958 CA SER 533 -32.221 203 .172 98. ,739 1.00 33 .48 B
ATOM 2959 CB SER 533 -33.636 203 .717 98. .593 1.00 33 .48 B
ATOM 2960 OG SER 533 -33.645 205 .101 98. .860 1.00 33 .48 B
ATOM 2961 C SER 533 -31.220 204 .263 98. ,389 1.00 33 .48 B
ATOM 2962 0 SER 533 -31.571205 .263 97. .784 1.00 33 .48 B
ATOM 2963 N ARG 534 -29.973 204 .066 98. .787 1.00 33 .48 B
ATOM 2964 CA ARG 534 -28.934 205 .036 98. .508 1.00 33 .48 B
ATOM 2965 CB ARG 534 -27.875 204 .961 99. ,585 1.00 33 .48 B
ATOM 2966 CG ARG 534 -26.790 205 .985 99. .461 1.00 33 .48 B
ATOM 2967 CD ARG 534 -25.963 205 .978 100. .726 1.00 33 .48 B
ATOM 2968 NE ARG 534 -26.810 206 .157 101. .903 1.00 33 .48 B
ATOM 2969 CZ ARG 534 -26.648 205 .499 103. .044 1.00 33 .48 B
ATOM 2970 NHl ARG 534 -25.665 204 .612 103, .175 1.00 33 .48 B
ATOM 2971 NH2 ARG 534 -27.483 205 .714 104, .044 1.00 33 .48 B
ATOM 2972 C ARG 534 -28.302 204 .780 97, .149 1.00 33 .48 B
ATOM 2973 0 ARG 534 -27.221204 .195 97, .062 1.00 33 .48 B
ATOM 2974 N TYR 535 -28.966 205 .230 96, .087 1.00 33 .48 B
ATOM 2975 CA TYR 535 -28.463 205 .013 94, .738 1.00 33 .48 B
ATOM 2976 CB TYR 535 -29.512 205 .434 93 .716 1.00 33 .48 B
ATOM 2977 CG TYR 535 -30.756 204 .593 93, . 777 1.00 33 .48 B
ATOM 2978 CDl TYR 535 -31.031203 .651 92 .800 1.00 33 .48 B
ATOM 2979 CEl TYR 535 -32.158 202 .841 92, .877 1.00 33 .48 B
ATOM 2980 CD2 TYR 535 -31.633 204 .715 94 .831 1.00 33 .48 B
ATOM 2981 CE2 TYR 535 -32.754 203 .921 94, .919 1.00 33 .48 B
ATOM 2982 CZ TYR 535 -33.016 202 .981 93 .945 1.00 33 .48 B
ATOM 2983 OH TYR 535 -34.122 202 .169 94, .065 1.00 33 .48 B
ATOM 2984 C TYR 535 -27.157 205 .717 94 .440 1.00 33 .48 B
ATOM 2985 0 TYR 535 -26.869 206 .761 95, .007 1.00 33 .48 B
ATOM 2986 N SER 536 -26.374 205 .115 93 .548 1.00 33 .48 B ATOM 2987 CA SER 536 -25.072 205.627 93.105 1.00 33.48 B
ATOM 2988 CB SER 536 -24.018 205.497 94.215 1.00 33 .48 B
ATOM 2989 OG SER 536 -24.203 204.333 95.000 1.00 33.48 B
ATOM 2990 C SER 536 -24.638 204.822 91.887 1.00 33 .48 B
ATOM 2991 0 SER 536 -25.339 203.904 91.467 1.00 33 .48 B
ATOM 2992 N SER 537 -23.499 205.166 91.300 1.00 33 .48 B
ATOM 2993 CA SER 537 -23.030 204.406 90.148 1.00 33 .48 B
ATOM 2994 CB SER 537 -21.954 205.174 89.386 1.00 33 .48 B
ATOM 2995 OG SER 537 -20.747 205.210 90.122 1.00 33 .48 B
ATOM 2996 C SER 537 -22.454 203.096 90.669 1.00 33 .48 B
ATOM 2997 0 SER 537 -22.322 202.127 89.937 1.00 33 .48 B
ATOM 2998 N LYS 538 -22.112 203.090 91.951 1.00 33 .48 B
ATOM 2999 CA LYS 538 -21.564 201.912 92.605 1.00 33 .48 B
ATOM 3000 CB LYS 538 -20.890 202.301 93.921 1.00 33 .48 B
ATOM 3001 CG LYS 538 -19.551 203.006 93.730 1.00 33 .48 B
ATOM 3002 CD LYS 538 -18.574 202.128 92.968 1.00 33 .48 B
ATOM 3003 CE LYS 538 -17.190 202.733 92.946 1.00 33.48 B
ATOM 3004 NZ LYS 538 -16.628 202.941 94.302 1.00 33 .48 B
ATOM 3005 C LYS 538 -22.650 200.877 92.866 1.00 33.48 B
ATOM 3006 0 LYS 538 -22.363 199.697 93.027 1.00 33 .48 B
ATOM 3007 N SER 539 -23.897 201.325 92.920 1.00 33 .48 B
ATOM 3008 CA SER 539 -24.997 200.406 93.118 1.00 33.48 B
ATOM 3009 CB SER 539 -26.211 201.113 93.721 1.00 33 .48 B
ATOM 3010 OG SER 539 -26.869 201.932 92.770 1.00 33 .48 B
ATOM 3011 C SER 539 -25.320 199.885 91.729 1.00 33.48 B
ATOM 3012 0 SER 539 -25.933 198.847 91.583 1.00 33 .48 B
ATOM 3013 N ASP 540 -24.912 200.625 90.708 1.00 33.48 B
ATOM 3014 CA ASP 540 -25.112 200.203 89.328 1.00 33 .48 B
ATOM 3015 CB ASP 540 -24.788 201.347 88.359 1.00 33.48 B
ATOM 3016 CG ASP 540 -26.016 202.114 87.919 1.00 33 .48 B
ATOM 3017 ODl ASP 540 -27.095 201.873 88.490 1.00 33.48 B
ATOM 3018 OD2 ASP 540 -25.908 202.957 87.009 1.00 33 .48 B
ATOM 3019 C ASP 540 -24.119 199.067 89.122 1.00 33.48 B
ATOM 3020 0 ASP 540 -24.382 198.102 88.419 1.00 33 .48 B
ATOM 3021 N VAL 541 -22.957 199.200 89.744 1.00 33.48 B
ATOM 3022 CA VAL 541 -21.949 198.173 89.640 1.00 33.48 B
ATOM 3023 CB VAL 541 -20.682 198.517 90.433 1.00 33 .48 B
ATOM 3024 CGl VAL 541 -19.858 197.264 90.653 1.00 33.48 B
ATOM 3025 CG2 VAL 541 -19.859 199.519 89.674 1.00 33 .48 B
ATOM 3026 C VAL 541 -22.537 196.893 90.194 1.00 33 .48 B
ATOM 3027 0 VAL 541 -22.543 195.874 89.512 1.00 33.48 B
ATOM 3028 N TRP 542 -23.044 196.935 91.422 1.00 33 .48 B
ATOM 3029 CA TRP 542 -23.623 195.733 92.006 1.00 33.48 B
ATOM 3030 CB TRP 542 -24.446 196.086 93.246 1.00 33.48 ATOM 3031 CG TRP 542 -25.043 194.895 93.938 1.00 33.48 B
ATOM 3032 CD2 TRP 542 -24.611194.309 95.174 1.00 33 .48 B
ATOM 3033 CE2 TRP 542 -25.445 193.209 95.425 1.00 33.48 B
ATOM 3034 CE3 TRP 542 -23.598 194.606 96.087 1.00 33.48 B
ATOM 3035 CDl TRP 542 -26.089194.145 93.508 1.00 33.48 B
ATOM 3036 NEl TRP 542 -26.339193.133 94.392 1.00 33.48 B
ATOM 3037 CZ2 TRP 542 -25.302 192.405 96.551 1.00 33.48 B
ATOM 3038 CZ3 TRP 542 -23.456 193.806 97.203 1.00 33.48 B
ATOM 3039 CH2 TRP 542 -24.305 192.718 97.426 1.00 33.48 B
ATOM 3040 C TRP 542 -24.493 195.025 90.966 1.00 33.48 B
ATOM 3041 0 TRP 542 -24.293 193.845 90.688 1.00 33.48 B
ATOM 3042 N SER 543 -25.430 195.763 90.373 1.00 33.48 B
ATOM 3043 CA SER 543 -26.331195.217 89.364 1.00 33.48 B
ATOM 3044 CB SER 543 -27.308 196.282 88.885 1.00 33.48 B
ATOM 3045 OG SER 543 -28.238 196.607 89.893 1.00 33.48 B
ATOM 3046 C SER 543 -25.609 194.645 88.162 1.00 33.48 B
ATOM 3047 0 SER 543 -26.154 193.817 87.450 1.00 33.48 B
ATOM 3048 N PHE 544 -24.393 195.098 87.914 1.00 33.48 B
ATOM 3049 CA PHE 544 -23.644 194.582 86.788 1.00 33.48 B
ATOM 3050 CB PHE 544 -22.464 195.507 86.465 1.00 33.48 B
ATOM 3051 CG PHE 544 -21.670195.089 85.256 1.00 33.48 B
ATOM 3052 CDl PHE 544 -22.201195.202 83.993 1.00 33 .48 B
ATOM 3053 CD2 PHE 544 -20.394 194.577 85.394 1.00 33 .48 B
ATOM 3054 CEl PHE 544 -21.478 194.815 82.901 1.00 33.48 B
ATOM 3055 CE2 PHE 544 -19.672 194.190 84.303 1.00 33.48 B
ATOM 3056 CZ PHE 544 -20.213 194.309 83.057 1.00 33.48 B
ATOM 3057 C PHE 544 -23.144 193.197 87.182 1.00 33.48 B
ATOM 3058 0 PHE 544 -23.108 192.283 86.366 1.00 33 .48 B
ATOM 3059 N GLY 545 -22.754 193.043 88.441 1.00 33.48 B
ATOM 3060 CA GLY 545 -22.275 191.753 88.882 1.00 33.48 B
ATOM 3061 C GLY 545 -23.350 190.716 88.621 1.00 33.48 B
ATOM 3062 0 GLY 545 -23.103 189.653 88.048 1.00 33.48 B
ATOM 3063 N VAL 546 -24.563 191.035 89.046 1.00 33.48 B
ATOM 3064 CA VAL 546 -25.684 190.143 88.857 1.00 33.48 B
ATOM 3065 CB VAL 546 -26.952 190.718 89.505 1.00 33.48 B
ATOM 3066 CGl VAL 546 -28.083 189.699 89.416 1.00 33.48 B
ATOM 3067 CG2 VAL 546 -26.666 191.087 90.951 1.00 33.48 B
ATOM 3068 C VAL 546 -25.938 189.877 87.372 1.00 33 .48 B
ATOM 3069 0 VAL 546 -25.974 188.727 86.957 1.00 33 .48 B
ATOM 3070 N LEU 547 -26.116 190.927 86.575 1.00 33.48 B
ATOM 3071 CA LEU 547 -26.351190.752 85.147 1.00 33.48 B
ATOM 3072 CB LEU 547 -26.488 192.114 84.454 1.00 33.48 B
ATOM 3073 CG LEU 547 -26.483 192.171 82.922 1.00 33.48 B
ATOM 3074 CDl LEU 547 -27.162 193.419 82.448 1.00 33.48 B ATOM 3075 CD2 LEU 547 -25.075 192.154 82.416 1.0033,.48 B
ATOM 3076 C LEU 547 -25.212 189.949 84.525 1.00 33, .48 B
ATOM 3077 O LEU 547 -25.389189.306 83.490 1.00 33, .48 B
ATOM 3078 N MET 548 -24.039 189.999 85.153 1.00 33, .48 B
ATOM 3079 CA MET 548 -22.888 189.249 84.668 1.00 33 .48 B
ATOM 3080 CB MET 548 -21.620 189.632 85.421 1.00 33, .48 B
ATOM 3081 CG MET 548 -20.830 190.775 84.822 1.00 33, .48 B
ATOM 3082 SD MET 548 -19.114190.729 85.364 1.00 33, .48 B
ATOM 3083 CE MET 548 -18.422 189.729 84.118 1.00 33, .48 B
ATOM 3084 C MET 548 -23.195 187.796 84.936 1.00 33, .48 B
ATOM 3085 0 MET 548 -22.923 186.926 84.118 1.00 33 .48 B
ATOM 3086 N TRP 549 -23.764 187.538 86.104 1.00 33 .48 B
ATOM 3087 CA TRP 549 -24.143 186.190 86.473 1.00 33, .48 B
ATOM 3088 CB TRP 549 -24.544 186.136 87.938 1.00 33, .48 B
ATOM 3089 CG TRP 549 -24.994184.785 88.406 1.00 33, .48 B
ATOM 3090 CD2 TRP 549 -26.320184.254 88.338 1.00 33, .48 B
ATOM 3091 CE2 TRP 549 -26.295 183.000 88.957 1.00 33, .48 B
ATOM 3092 CE3 TRP 549 -27.527 184.722 87.814 1.00 33 .48 B
ATOM 3093 CDl TRP 549 -24.242 183.850 89.035 1.00 33 .48 B
ATOM 3094 NEl TRP 549 -25.012 182.777 89.375 1.00 33 .48 B
ATOM 3095 CZ2 TRP 549 -27.429 182.205 89.070 1.00 33 .48 B
ATOM 3096 CZ3 TRP 549 -28.643 183.936 87.927 1.00 33 .48 B
ATOM 3097 CH2 TRP 549 -28.590182.690 88.551 1.00 33 .48 B
ATOM 3098 C TRP 549 -25.319 185.717 85.634 1.00 33 .48 B
ATOM 3099 0 TRP 549 -25.504 184.533 85.467 1.00 33 .48 B
ATOM 3100 N GLU 550 -26.124 186.631 85.113 1.00 33 .48 B
ATOM 3101 CA GLU 550 -27.274 186.229 84,315 1.00 33 .48 B
ATOM 3102 CB GLU 550 -28.253 187.385 84.165 1.00 33 .48 B
ATOM 3103 CG GLU 550 -28.759 187.944 85.465 1.00 33 .48 B
ATOM 3104 CD GLU 550 -29.922 188.879 85.254 1.00 33 .48 B
ATOM 3105 OEl GLU 550 -31.062 188.393 85.118 1.00 33 .48 B
ATOM 3106 OE2 GLU 550 -29.695 190.102 85.206 1.00 33 .48 B
ATOM 3107 C GLU 550 -26.878 185.749 82.932 1.00 33 .48 B
ATOM 3108 0 GLU 550 -27.395 184.755 82.419 1.00 33, .48 B
ATOM 3109 N VAL 551 -25.958 186.476 82.327 1.00 33, .48 B
ATOM 3110 CA VAL 551 -25.483 186.164 80.999 1.00 33, .48 B
ATOM 3111 CB VAL 551 -24.602 187.326 80.485 1.00 33 .48 B
ATOM 3112 CGl VAL 551 -23.906 186.952 79.208 1.00 33 .48 B
ATOM 3113 CG2 VAL 551 -25.457 188.545 80.280 1.00 33 .48 B
ATOM 3114 C VAL 551 -24.713 184.850 80.988 1.00 33 .48 B
ATOM 3115 0 VAL 551 -25.063 183.926 80.265 1.00 33 .48 B
ATOM 3116 N PHE 552 -23.675 184.767 81.812 1.00 33 .48 B
ATOM 3117 CA PHE 552 -22.840 183.576 81.876 1.00 33 .48 B
ATOM 3118 CB PHE 552 -21.679 183.805 82.856 1.00 33 .48 B ATOM 3119 CG PHE 552 -20.480 184.451 82.226 1.0033.,48 B
ATOM 3120 CDl PHE 552 -19.686 183.746 81.347 1.00 33. ,48 B
ATOM 3121 CD2 PHE 552 -20.179 185.776 82.465 1.00 33. ,48 B
ATOM 3122 CEl PHE 552 -18.623 184.346 80.715 1.00 33. ,48 B
ATOM 3123 CE2 PHE 552 -19.111 186.386 81.833 1.00 33. ,48 B
ATOM 3124 CZ PHE 552 -18.336 185.666 80.955 1.00 33. ,48 B
ATOM 3125 C PHE 552 -23.630 182.318 82.233 1.00 33. ,48 B
ATOM 3126 0 PHE 552 -23.233 181.197 81.885 1.00 33. ,48 B
ATOM 3127 N SER 553 -24.746 182.509 82.927 1.00 33. .48 B
ATOM 3128 CA SER 553 -25.598 181.397 83.295 1.00 33. .48 B
ATOM 3129 CB SER 553 -25.962 181.451 84.775 1.00 33, .48 B
ATOM 3130 OG SER 553 -26.940 182.427 85.026 1.00 33. .48 B
ATOM 3131 C SER 553 -26.831181.544 82.422 1.00 33. .48 B
ATOM 3132 0 SER 553 -27.966 181.477 82.881 1.00 33, .48 B
ATOM 3133 N GLU 554 -26.560181.765 81.142 1.00 33, .48 B
ATOM 3134 CA GLU 554 -27.556 181.943 80.097 1.00 33, .48 B
ATOM 3135 CB GLU 554 -27.439 180.806 79.091 1.00 33, .48 B
ATOM 3136 CG GLU 554 -26.179 180.002 79.237 1.00 33, .48 B
ATOM 3137 CD GLU 554 -26.001179.023 78.100 1.00 33, .48 B
ATOM 3138 OEl GLU 554 -25.654 179.485 76.994 1.00 33, .48 B
ATOM 3139 OE2 GLU 554 -26.218 177.802 78.302 1.00 33, .48 B
ATOM 3140 C GLU 554 -29.023 182.103 80.477 1.00 33, .48 B
ATOM 3141 0 GLU 554 -29.819 181.185 80.296 1.00 33, .48 B
ATOM 3142 N GLY 555 -29.383 183.264 81.001 1.00 33, .48 B
ATOM 3143 CA GLY 555 -30.774 183.506 81.310 1.00 33, .48 B
ATOM 3144 C GLY 555 -31.380 182.938 82.573 1.00 33, .48 B
ATOM 3145 0 GLY 555 -32.554 183.197 82.841 1.00 33, .48 B
ATOM 3146 N LYS 556 -30.634 182.167 83.353 1.00 33 .48 B
ATOM 3147 CA LYS 556 -31.214 181.647 84.578 1.00 33 .48 B
ATOM 3148 CB LYS 556 -30.219 180.732 85.293 1.00 33 .48 B
ATOM 3149 CG LYS 556 -30.540 179.244 85.133 1.00 33 .48 B
ATOM 3150 CD LYS 556 -29.299 178.349 85.218 1.00 33 .48 B
ATOM 3151 CE LYS 556 -28.376 178.577 84.018 1.00 33 .48 B
ATOM 3152 NZ LYS 556 -27.282 177.567 83.917 1.00 33 .48 B
ATOM 3153 C LYS 556 -31.627 182.812 85.478 1.00 33 .48 B
ATOM 3154 0 LYS 556 -31.029 183.885 85.436 1.00 33 .48 B
ATOM 3155 N ILE 557 -32.667 182.598 86.274 1.00 33 .48 B
ATOM 3156 CA ILE 557 -33.191 183.605 87.191 1.00 33 .48 B
ATOM 3157 CB ILE 557 -34.707 183.401 87.418 1.00 33 .48 B
ATOM 3158 CG2 ILE 557 -35.084 183.852 88.794 1.00 33 .48 B
ATOM 3159 CGl ILE 557 -35.511184.150 86.354 1.00 33 .48 B
ATOM 3160 CDl ILE 557 -35.274 185.675 86.345 1.00 33 .48 B
ATOM 3161 C ILE 557 -32.490 183.540 88.537 1.00 33 .48 B
ATOM 3162 0 ILE 557 -32.461182.502 89.180 1.00 33 .48 B ATOM 3163 N PRO 558 -31.921 184.667 88.982 1.00 33.,48 B
ATOM 3164 CD PRO 558 -31.869 185.891 88.169 1.00 33, ,48 B
ATOM 3165 CA PRO 558 -31.187 184.857 90.242 1.00 33. ,48 B
ATOM 3166 CB PRO 558 -30.731 186.309 90.153 1.00 33, .48 B
ATOM 3167 CG PRO 558 -30.622 186.546 88.681 1.00 33, ,48 B
ATOM 3168 C PRO 558 -32.006 184.596 91.510 1.00 33, .48 B
ATOM 3169 O PRO 558 -33.164 185.003 91.610 1.00 33, .48 B
ATOM 3170 N TYR 559 -31.386 183.933 92.482 1.00 33, .48 B
ATOM 3171 CA TYR 559 -32.037 183.600 93.742 1.00 33. .48 B
ATOM 3172 CB TYR 559 -32.071 184.794 94.675 1.00 33, .48 B
ATOM 3173 CG TYR 559 -30.892 185.712 94.589 1.00 33, .48 B
ATOM 3174 CDl TYR 559 -30.915 186.815 93.754 1.00 33, .48 B
ATOM 3175 CEl TYR 559 -29.894 187.715 93.762 1.00 33, .48 B
ATOM 3176 CD2 TYR 559 -29.796 185.540 95.418 1.00 33, .48 B
ATOM 3177 CE2 TYR 559 -28.778 186.436 95.430 1.00 33, .48 B
ATOM 3178 CZ TYR 559 -28.834 187.521 94.608 1.00 33, .48 B
ATOM 3179 OH TYR 559 -27.841 188.455 94.664 1.00 33, .48 B
ATOM 3180 C TYR 559 -33.467 183.151 93.512 1.00 33, .48 B
ATOM 3181 0 TYR 559 -34.361 183.488 94.278 1.00 33, .48 B
ATOM 3182 N GLU 560 -33.675 182.399 92.442 1.00 33 .48 B
ATOM 3183 CA GLU 560 -34.990 181.887 92.079 1.00 33, .48 B
ATOM 3184 CB GLU 560 -34.838 180.926 90.895 1.00 33 .48 B
ATOM 3185 CG GLU 560 -36.120 180.296 90.396 1.00 33 .48 B
ATOM 3186 CD GLU 560 -35.891 179.497 89.126 1.00 33 .48 B
ATOM 3187 OEl GLU 560 -36.868 178.907 88.601 1.00 33 .48 B
ATOM 3188 OE2 GLU 560 -34.726 179.465 88.653 1.00 33 .48 B
ATOM 3189 C GLU 560 -35.674 181.182 93.255 1.00 33 .48 B
ATOM 3190 0 GLU 560 -36.757 181.593 93.699 1.00 33 .48 B
ATOM 3191 N ASN 561 -35.039 180.127 93.763 1.00 33, .48 B
ATOM 3192 CA ASN 561 -35.597 179.379 94.884 1.00 33 .48 B
ATOM 3193 CB ASN 561 -34.596 178.320 95.362 1.00 33 .48 B
ATOM 3194 CG ASN 561 -35.145 177.466 96.509 1.00 33 .48 B
ATOM 3195 ODl ASN 561 -36.165 176.767 96.354 1.00 33 .48 B
ATOM 3196 ND2 ASN 561 -34.473 177.519 97.668 1.00 33 .48 B
ATOM 3197 C ASN 561 -35.964 180.287 96.059 1.00 33 .48 B
ATOM 3198 0 ASN 561 -36.908 180.005 96.798 1.00 33 .48 B
ATOM 3199 N ARG 562 -35.212 181.377 96.208 1.00 33 .48 B
ATOM 3200 CA ARG 562 -35.391 182.339 97.288 1.00 33 .48 B
ATOM 3201 CB ARG 562 -34.066 183.028 97.555 1.00 33 .48 B
ATOM 3202 CG ARG 562 -32.974 182.057 97.855 1.00 33 .48 B
ATOM 3203 CD ARG 562 -33.295 181.318 99.125 1.00 33 .48 B
ATOM 3204 NE ARG 562 -32.493 181.805 100.246 1.00 33 .48 B
ATOM 3205 CZ ARG 562 -32.698 181.457 101.515 1.00 33 .48 B
ATOM 3206 NHl ARG 562 -33.692 180.623 101.815 1.00 33 .48 B ATOM 3207 NH2 ARG 562 -31.895 181.916 102.477 1.00 33.48 B
ATOM 3208 C ARG 562 -36.454 183.402 97.076 1.00 33.48 B
ATOM 3209 O ARG 562 -36.916 183.636 95.967 1.00 33.48 B
ATOM 3210 N SER 563 -36.826184.050 98.172 1.00 33.48 B
ATOM 3211 CA SER 563 -37.813 185.117 98.162 1.00 33.48 B
ATOM 3212 CB SER 563 -38.952 184.767 99.090 1.00 33.48 B
ATOM 3213 OG SER 563 -38.503 184.891 100.426 1.00 33.48 B
ATOM 3214 C SER 563 -37.148186.396 98.681 1.00 33.48 B
ATOM 3215 O SER 563 -36.325 186.351 99.596 1.00 33.48 B
ATOM 3216 N ASN 564 -37.527 187.530 98.103 1.00 33.48 B
ATOM 3217 CA ASN 564 -36.983 188.833 98.474 1.00 33.48 B
ATOM 3218 CB ASN 564 -38.044 189.898 98.262 1.00 33.48 B
ATOM 3219 CG ASN 564 -38.228 190.231 96.813 1.00 33.48 B
ATOM 3220 ODl ASN 564 -37.942 189.415 95.934 1.00 33.48 B
ATOM 3221 ND2 ASN 564 -38.714191.433 96.543 1.00 33.48 B
ATOM 3222 C ASN 564 -36.456 188.912 99.899 1.00 33.48 B
ATOM 3223 O ASN 564 -35.349 189.401 100.140 1.00 33.48 B
ATOM 3224 N SER 565 -37.245 188.431 100.849 1.00 33.48 B
ATOM 3225 CA SER 565 -36.814 188.470 102.229 1.00 33.48 B
ATOM 3226 CB SER 565 -37.920 187.962 103.138 1.00 33.48 B
ATOM 3227 OG SER 565 -37.419 187.759 104.443 1.00 33.48 B
ATOM 3228 C SER 565 -35.565 187.629 102.432 1.00 33.48 B
ATOM 3229 O SER 565 -34.585 188.071 103.035 1.00 33.48 B
ATOM 3230 N GLU 566 -35.603 186.407 101.922 1.00 33.48 B
ATOM 3231 CA GLU 566 -34.479 185.504 102.063 1.00 33.48 B
ATOM 3232 CB GLU 566 -34.848 184.125 101.534 1.00 33.48 B
ATOM 3233 CG GLU 566 -36.252 183.707 101.915 1.00 33.48 B
ATOM 3234 CD GLU 566 -36.560 182.288 101.520 1.00 33.48 B
ATOM 3235 OEl GLU 566 -35.987 181.369 102.150 1.00 33.48 B
ATOM 3236 OE2 GLU 566 -37.365 182.094 100.578 1.00 33.48 B
ATOM 3237 C GLU 566 -33.298 186.054 101.301 1.00 33.48 B
ATOM 3238 O GLU 566 -32.159 185.853 101.699 1.00 33.48 B
ATOM 3239 N VAL 567 -33.557 186.756 100.206 1.00 33.48 B
ATOM 3240 CA VAL 567 -32.450 187.311 99.446 1.00 33.48 B
ATOM 3241 CB VAL 567 -32.916 187.998 98.167 1.00 33.48 B
ATOM 3242 CGl VAL 567 -31.719 188.519 97.403 1.00 33.48 B
ATOM 3243 CG2 VAL 567 -33.710 187.014 97.309 1.00 33.48 B
ATOM 3244 C VAL 567 -31.751188.322 100.324 1.00 33.48 B
ATOM 3245 O VAL 567 -30.544 188.228 100.553 1.00 33.48 B
ATOM 3246 N VAL 568 -32.519189.282 100.834 1.00 33.48 B
ATOM 3247 CA VAL 568 -31.973 190.313 101.713 1.00 33.48 B
ATOM 3248 CB VAL 568 -33.063 191.247 102.208 1.00 33.48 B
ATOM 3249 CGl VAL 568 -32.628 191.900 103.473 1.00 33.48 B
ATOM 3250 CG2 VAL 568 -33.328 192.301 101.175 1.00 33.48 B ATOM 3251 C VAL 568 -31.292 189.687 102.918 1.00 33.48 B
ATOM 3252 O VAL 568 -30.203 190.092 103.322 1.00 33.48 B
ATOM 3253 N GLU 569 -31.944 188.694 103.499 1.00 33.48 B
ATOM 3254 CA GLU 569 -31.379 188.009 104.644 1.00 33.48 B
ATOM 3255 CB GLU 569 -32.392 187.002 105.181 1.00 33.48 B
ATOM 3256 CG GLU 569 -31.867 186.058 106.254 1.00 33.48 B
ATOM 3257 CD GLU 569 -31.307 186.787 107.448 1.00 33.48 B
ATOM 3258 OEl GLU 569 -31.879 187.836 107.837 1.00 33.48 B
ATOM 3259 OE2 GLU 569 -30.296 186.301108.004 1.00 33.48 B
ATOM 3260 C GLU 569 -30.094 187.306 104.223 1.00 33.48 B
ATOM 3261 O GLU 569 -29.139 187.251 104.985 1.00 33.48 B
ATOM 3262 N ASP 570 -30.066 186.781 103.002 1.00 33.48 B
ATOM 3263 CA ASP 570 -28.884 186.076 102.519 1.00 33.48 B
ATOM 3264 CB ASP 570 -29.229 185.189 101.314 1.00 33.48 B
ATOM 3265 CG ASP 570 -29.870 183.856 101.720 1.00 33.48 B
ATOM 3266 ODl ASP 570 -30.228 183.057 100.821 1.00 33.48 B
ATOM 3267 OD2 ASP 570 -30.016 183.599 102.936 1.00 33.48 B
ATOM 3268 C ASP 570 -27.743 187.018 102.162 1.00 33.48 B
ATOM 3269 O ASP 570 -26.617 186.819 102.617 1.00 33.48 B
ATOM 3270 N ILE 571 -28.028 188.037 101.349 1.00 33.48 B
ATOM 3271 CA ILE 571 -27.006 189.006 100.948 1.00 33.48 B
ATOM 3272 CB ILE 571 -27.588 190.140 100.092 1.00 33.48 B
ATOM 3273 CG2 ILE 571 -26.905 191.440 100.448 1.00 33.48 B
ATOM 3274 CGl ILE 571 -27.360 189.865 98.613 1.00 33.48 B
ATOM 3275 CDl ILE 571 -27.806 188.526 98.175 1.00 33.48 B
ATOM 3276 C ILE 571 -26.395 189.653 102.178 1.00 33.48 B
ATOM 3277 O ILE 571 -25.180 189.767 102.302 1.00 33.48 B
ATOM 3278 N SER 572 -27.264 190.076 103.082 1.00 33.48 B
ATOM 3279 CA SER 572 -26.865 190.729 104.307 1.00 33.48 B
ATOM 3280 CB SER 572 -28.098 190.947 105.168 1.00 33.48 B
ATOM 3281 OG SER 572 -27.726 191.512 106.407 1.00 33.48 B
ATOM 3282 C SER 572 -25.831 189.945 105.096 1.00 33.48 B
ATOM 3283 O SER 572 -25.189 190.477 105.995 1.00 33.48 B
ATOM 3284 N THR 573 -25.667 188.679 104.744 1.00 33.48 B
ATOM 3285 CA THR 573 -24.742 187.798 105.436 1.00 33.48 B
ATOM 3286 CB THR 573 -25.499 186.603 106.043 1.00 33.48 B
ATOM 3287 OGl THR 573 -26.543 187.091106.893 1.00 33.48 B
ATOM 3288 CG2 THR 573 -24.569 185.729 106.865 1.00 33.48 B
ATOM 3289 C THR 573 -23.635 187.263 104.544 1.00 33.48 B
ATOM 3290 O THR 573 -23.234 186.116 104.667 1.00 33.48 B
ATOM 3291 N GLY 574 -23.153 188.076 103.622 1.00 33.48 B
ATOM 3292 CA GLY 574 -22.066 187.627 102.774 1.00 33.48 B
ATOM 3293 C GLY 574 -22.322 186.489 101.809 1.00 33.48 B
ATOM 3294 O GLY 574 -21.394 186.019 101.151 1.00 33.48 B ATOM 3295 N PHE 575 -23.559 186.025 101.714 1.00 33.48 B
ATOM 3296 CA PHE 575 -23.842 184.959 100.769 1.00 33 .48 B
ATOM 3297 CB PHE 575 -25.048 184.126 101.224 1.00 33.48 B
ATOM 3298 CG PHE 575 -24.781183.310 102.461 1.00 33 .48 B
ATOM 3299 CDl PHE 575 -25.250 183.711103.690 1.00 33.48 B
ATOM 3300 CD2 PHE 575 -23.995 182.179 102.399 1.00 33 .48 B
ATOM 3301 CEl PHE 575 -24.932 183.001104.825 1.00 33.48 B
ATOM 3302 CE2 PHE 575 -23.679 181.475 103.534 1.00 33 .48 B
ATOM 3303 CZ PHE 575 -24.146 181.886 104.742 1.00 33 .48 B
ATOM 3304 C PHE 575 -24.094 185.627 99.425 1.00 33 .48 B
ATOM 3305 0 PHE 575 -24.667 186.713 99.359 1.00 33 .48 B
ATOM 3306 N ARG 576 -23.653 184.984 98.355 1.00 33 .48 B
ATOM 3307 CA ARG 576 -23.798 185.549 97.023 1.00 33 .48 B
ATOM 3308 CB ARG 576 -22.451186.118 96.579 1.00 33 .48 B
ATOM 3309 CG ARG 576 -21.907 187.187 97.513 1.00 33 .48 B
ATOM 3310 CD ARG 576 -22.654 188.503 97.341 1.00 33 .48 B
ATOM 3311 NE ARG 576 -22.089 189.569 98.157 1.00 33 .48 B
ATOM 3312 CZ ARG 576 -22.461189.827 99.398 1.00 33.48 B
ATOM 3313 NHl ARG 576 -23.402 189.104 99.970 1.00 33 .48 B
ATOM 3314 NH2 ARG 576 -21.892 190.804 100.068 1.00 33.48 B
ATOM 3315 C ARG 576 -24.257 184.500 96.032 1.00 33 .48 B
ATOM 3316 0 ARG 576 -24.488 183.358 96.396 1.00 33.48 B
ATOM 3317 N LEU 577 -24.392 184.889 94.774 1.00 33 .48 B
ATOM 3318 CA LEU 577 -24.797 183.949 93.751 1.00 33.48 B
ATOM 3319 CB LEU 577 -25.177 184.691 92.469 1.00 33 .48 B
ATOM 3320 CG LEU 577 -26.394 185.618 92.516 1.00 33 .48 B
ATOM 3321 CDl LEU 577 -26.484 186.445 91.238 1.00 33 .48 B
ATOM 3322 CD2 LEU 577 -27.646 184.796 92.709 1.00 33 .48 B
ATOM 3323 C LEU 577 -23.602 183.042 93.499 1.00 33 .48 B
ATOM 3324 0 LEU 577 -22.471 183.499 93.521 1.00 33 .48 B
ATOM 3325 N TYR 578 -23.843 181.756 93.264 1.00 33 .48 B
ATOM 3326 CA TYR 578 -22.749 180.826 93.024 1.00 33 .48 B
ATOM 3327 CB TYR 578 -23.206 179.382 93.208 1.00 33 .48 B
ATOM 3328 CG TYR 578 -23.601179.031 94.623 1.00 33 .48 B
ATOM 3329 CDl TYR 578 -24.904 179.182 95.053 1.00 33.48 B
ATOM 3330 CEl TYR 578 -25.259 178.902 96.345 1.00 33.48 B
ATOM 3331 CD2 TYR 578 -22.657 178.585 95.534 1.00 33.48 B
ATOM 3332 CE2 TYR 578 -23.002 178.307 96.827 1.00 33.48 B
ATOM 3333 CZ TYR 578 -24.308 178.469 97.228 1.00 33.48 B
ATOM 3334 OH TYR 578 -24.667 178.212 98.527 1.00 33 .48 B
ATOM 3335 C TYR 578 -22.131180.979 91.656 1.00 33.48 B
ATOM 3336 0 TYR 578 -22.678 181.637 90.787 1.00 33 .48 B
ATOM 3337 N LYS 579 -20.982 180.350 91.473 1.00 33.48 B
ATOM 3338 CA LYS 579 -20.259 180.433 90.213 1.00 33 .48 B ATOM 3339 CB LYS 579 -18.845 179.871 90.372 1.00 33..48 B
ATOM 3340 CG LYS 579 -18.149 179.646 89.042 1.00 33, ,48 B
ATOM 3341 CD LYS 579 -16.795 179. Oil 89.230 1.00 33, ,48 B
ATOM 3342 CE LYS 579 -16.201178.586 87.907 1.00 33, .48 B
ATOM 3343 NZ LYS 579 -16.950177.446 87.349 1.00 33, .48 B
ATOM 3344 C LYS 579 -20.914 179.746 89.033 1.00 33, .48 B
ATOM 3345 O LYS 579 -21.208 178.556 89.065 1.00 33, .48 B
ATOM 3346 N PRO 580 -21.173 180.495 87.972 1.00 33, .48 B
ATOM 3347 CD PRO 580 -21.442 181.932 87.892 1.00 33, .48 B
ATOM 3348 CA PRO 580 -21.788 179.790 86.860 1.00 33. .48 B
ATOM 3349 CB PRO 580 -22.307 180.922 85.971 1.00 33, .48 B
ATOM 3350 CG PRO 580 -21.568 182.121 86.431 1.00 33. .48 B
ATOM 3351 C PRO 580 -20.797 178.859 86.160 1.00 33. .48 B
ATOM 3352 O PRO 580 -19.608 179.147 86.055 1.00 33, .48 B
ATOM 3353 N ARG 581 -21.305 177.723 85.703 1.00 33, .48 B
ATOM 3354 CA ARG 581 -20.504 176.731 85.022 1.00 33, .48 B
ATOM 3355 CB ARG 581 -21.420 175.663 84.428 1.00 33, .48 B
ATOM 3356 CG ARG 581 -20.707 174.445 83.875 1.00 33, .48 B
ATOM 3357 CD ARG 581 -20.862 173.239 84.806 1.00 33, .48 B
ATOM 3358 NE ARG 581 -22.232 172.714 84.840 1.00 33, .48 B
ATOM 3359 CZ ARG 581 -23.023 172.684 85.915 1.00 33, .48 B
ATOM 3360 NHl ARG 581 -22.605 173.148 87.091 1.00 33, .48 B
ATOM 3361 NH2 ARG 581 -24.255 172.201 85.804 1.00 33, .48 B
ATOM 3362 C ARG 581 -19.712 177.403 83.924 1.00 33, .48 B
ATOM 3363 O ARG 581 -18.520177.203 83.806 1.00 33, .48 B
ATOM 3364 N LEU 582 -20.373 178.224 83.124 1.00 33, .48 B
ATOM 3365 CA LEU 582 -19.701178.899 82.021 1.00 33, .48 B
ATOM 3366 CB LEU 582 -20.718 179.296 80.952 1.00 33, .48 B
ATOM 3367 CG LEU 582 -21.154 178.179 80.006 1.00 33, .48 B
ATOM 3368 CDl LEU 582 -22.077 178.751 78.944 1.00 33, ,48 B
ATOM 3369 CD2 LEU 582 -19.937 177.548 79.361 1.00 33, .48 B
ATOM 3370 C LEU 582 -18.863 180.117 82.367 1.00 33, .48 B
ATOM 3371 O LEU 582 -18.473 180.851 81.472 1.00 33, .48 B
ATOM 3372 N ALA 583 -18.571180.332 83.643 1.00 33, .48 B
ATOM 3373 CA ALA 583 -17.789181.493 84.038 1.00 33, .48 B
ATOM 3374 CB ALA 583 -18.561182.302 85.041 1.00 33 .48 B
ATOM 3375 C ALA 583 -16.440181.122 84.622 1.00 33 .48 B
ATOM 3376 O ALA 583 -16.364180.314 85.546 1.00 33 .48 B
ATOM 3377 N SER 584 -15.371181.714 84.102 1.00 33 .48 B
ATOM 3378 CA SER 584 -14.050181.408 84.621 1.00 33 .48 B
ATOM 3379 CB SER 584 -12.974182.176 83.863 1.00 33 .48 B
ATOM 3380 OG SER 584 -12.861183.505 84.336 1.00 33 .48 B
ATOM 3381 C SER 584 -13.993 181.770 86.103 1.00 33 .48 B
ATOM 3382 O SER 584 -14.856182.464 86.621 1.00 33 .48 B ATOM 3383 N THR 585 -12.973 181.293 86.794 1.0033,.48 B
ATOM 3384 CA THR 585 -12.863 181.592 88.202 1.00 33, .48 B
ATOM 3385 CB THR 585 -11.793 180.732 88.854 1.00 33, .48 B
ATOM 3386 OGl THR 585 -10.508 181.133 88.383 1.00 33, .48 B
ATOM 3387 CG2 THR 585 -12.010 179.285 88.503 1.00 33, .48 B
ATOM 3388 C THR 585 -12.505 183.049 88.364 1.00 33, .48 B
ATOM 3389 O THR 585 -12.784 183.655 89.382 1.00 33, .48 B
ATOM 3390 N HIS 586 -11.884 183.614 87.345 1.00 33, .48 B
ATOM 3391 CA HIS 586 -11.503 185.010 87.399 1.00 33, .48 B
ATOM 3392 CB HIS 586 -10.439 185.311 86.339 1.00 33, .48 B
ATOM 3393 CG HIS 586 -9.966 186.735 86.341 1.00 33, .48 B
ATOM 3394 CD2 HIS 586 -9.170 187.411 85.476 1.00 33, .48 B
ATOM 3395 NDl HIS 586 -10.292 187.632 87.341 1.00 33, .48 B
ATOM 3396 CEl HIS 586 -9.719 188.796 87.090 1.00 33 .48 B
ATOM 3397 NE2 HIS 586 -9.031188.687 85.965 1.00 33, .48 B
ATOM 3398 C HIS 586 -12.754 185.852 87.164 1.00 33, .48 B
ATOM 3399 0 HIS 586 -13.039 186.791 87.909 1.00 33, .48 B
ATOM 3400 N VAL 587 -13.499 185.504 86.125 1.00 33, .48 B
ATOM 3401 CA VAL 587 -14.724 186.208 85.802 1.00 33, .48 B
ATOM 3402 CB VAL 587 -15.449 185.498 84.659 1.00 33, .48 B
ATOM 3403 CGl VAL 587 -16.842 186.042 84.502 1.00 33, .48 B
ATOM 3404 CG2 VAL 587 -14.653 185.663 83.381 1.00 33, .48 B
ATOM 3405 C VAL 587 -15.625 186.262 87.029 1.00 33, .48 B
ATOM 3406 0 VAL 587 -16.332 187.240 87.247 1.00 33. .48 B
ATOM 3407 N TYR 588 -15.579 185.203 87.832 1.00 33, .48 B
ATOM 3408 CA TYR 588 -16.383 185.097 89.049 1.00 33, .48 B
ATOM 3409 CB TYR 588 -16.528 183.626 89.455 1.00 33, .48 B
ATOM 3410 CG TYR 588 -17.429 183.392 90.642 1.00 33, .48 B
ATOM 3411 CDl TYR 588 -18.767 183.754 90.606 1.00 33, .48 B
ATOM 3412 CEl TYR 588 -19.586 183.556 91.690 1.00 33, .48 B
ATOM 3413 CD2 TYR 588 -16.940 182.821 91.803 1.00 33, .48 B
ATOM 3414 CE2 TYR 588 -17.754 182.623 92.889 1.00 33, .48 B
ATOM 3415 CZ TYR 588 -19.073 182.991 92.825 1.00 33, .48 B
ATOM 3416 OH TYR 588 -19.882 182.777 93.903 1.00 33, .48 B
ATOM 3417 C TYR 588 -15.752 185.900 90.180 1.00 33, .48 B
ATOM 3418 0 TYR 588 -16.407 186.253 91.153 1.00 33, .48 B
ATOM 3419 N GLN 589 -14.466 186.181 90.057 1.00 33, .48 B
ATOM 3420 CA GLN 589 -13.799 186.984 91.066 1.00 33, .48 B
ATOM 3421 CB GLN 589 -12.301187.045 90.787 1.00 33, .48 B
ATOM 3422 CG GLN 589 -11.673 185.677 90.795 1.00 33, .48 B
ATOM 3423 CD GLN 589 -10.226 185.693 91.210 1.00 33, .48 B
ATOM 3424 OEl GLN 589 -9.885 186.174 92.293 1.00 33, .48 B
ATOM 3425 NE2 GLN 589 -9.361 185.154 90.356 1.00 33, .48 B
ATOM 3426 C GLN 589 -14.407 188.374 90.977 1.00 33. ,48 B ATOM 3427 0 GLN 589 -14.896 188.919 91.960 1.00 33.48 B
ATOM 3428 N ILE 590 -14.379 188.904 89.759 1.00 33.48 B
ATOM 3429 CA ILE 590 -14.906190.207 89.406 1.00 33.48 B
ATOM 3430 CB ILE 590 -14.843 190.412 87.880 1.00 33.48 B
ATOM 3431 CG2 ILE 590 -15.520191.716 87.491 1.00 33.48 B
ATOM 3432 CGl ILE 590 -13.385 190.382 87.420 1.00 33.48 B
ATOM 3433 CDl ILE 590 -13.199 190.365 85.933 1.00 33.48 B
ATOM 3434 C ILE 590 -16.340190.339 89.860 1.00 33.48 B
ATOM 3435 0 ILE 590 -16.733 191.382 90.391 1.00 33.48 B
ATOM 3436 N MET 591 -17.126189.289 89.650 1.00 33.48 B
ATOM 3437 CA MET 591 -18.521189.313 90.056 1.00 33.48 B
ATOM 3438 CB MET 591 -19.221187.996 89.687 1.00 33.48 B
ATOM 3439 CG MET 591 -19.567 187.860 88.200 1.00 33.48 B
ATOM 3440 SD MET 591 -20.209 186.246 87.670 1.00 33.48 B
ATOM 3441 CE MET 591 -20.976185.771 89.107 1.00 33.48 B
ATOM 3442 C MET 591 -18.613 189.572 91.551 1.00 33.48 B
ATOM 3443 0 MET 591 -19.415 190.375 91.985 1.00 33.48 B
ATOM 3444 N ASN 592 -17.786 188.905 92.342 1.00 33 .48 B
ATOM 3445 CA ASN 592 -17.826 189.120 93.783 1.00 33.48 B
ATOM 3446 CB ASN 592 -17.043 188.037 94.520 1.00 33.48 B
ATOM 3447 CG ASN 592 -17.632 186.670 94.336 1.00 33.48 B
ATOM 3448 ODl ASN 592 -18.671186.347 94.893 1.00 33.48 B
ATOM 3449 ND2 ASN 592 -16.971185.857 93.540 1.00 33.48 B
ATOM 3450 C ASN 592 -17.209 190.464 94.093 1.00 33.48 B
ATOM 3451 0 ASN 592 -17.296 190.972 95.204 1.00 33 .48 B
ATOM 3452 N HIS 593 -16.564 191.045 93.101 1.00 33 .48 B
ATOM 3453 CA HIS 593 -15.944 192.333 93.308 1.00 33.48 B
ATOM 3454 CB HIS 593 -14.805 192.526 92.320 1.00 33.48 B
ATOM 3455 CG HIS 593 -13.844193.593 92.724 1.00 33.48 B
ATOM 3456 CD2 HIS 593 -13.832 194.415 93.799 1.00 33.48 B
ATOM 3457 NDl HIS 593 -12.753 193.945 91.955 1.00 33.48 B
ATOM 3458 CEl HIS 593 -12.114 194.944 92.538 1.00 33.48 B
ATOM 3459 NE2 HIS 593 -12.749 195.249 93.657 1.00 33.48 B
ATOM 3460 C HIS 593 -17.012 193.406 93.137 1.00 33.48 B
ATOM 3461 0 HIS 593 -16.923 194.478 93.729 1.00 33.48 B
ATOM 3462 N CYS 594 -18.029 193.107 92.335 1.00 33.48 B
ATOM 3463 CA CYS 594 -19.114 194.042 92.123 1.00 33.48 B
ATOM 3464 CB CYS 594 -19.859 193.723 90.835 1.00 33.48 B
ATOM 3465 SG CYS 594 -18.854 193.646 89.359 1.00 33.48 B
ATOM 3466 C CYS 594 -20.097 193.937 93.268 1.00 33.48 B
ATOM 3467 0 CYS 594 -20.932 194.821 93.451 1.00 33.48 B
ATOM 3468 N TRP 595 -19.996 192.854 94.039 1.00 33.48 B
ATOM 3469 CA TRP 595 -20.922 192.593 95.141 1.00 33.48 B
ATOM 3470 CB TRP 595 -21.477 191.172 95.050 1.00 33 .48 B ATOM 3471 CG TRP 595 -22.199 190.859 93.791 1.00 33.48 B
ATOM 3472 CD2 TRP 595 -22.197 189.610 93.094 1.00 33.48 B
ATOM 3473 CE2 TRP 595 -23.045 189.752 91.984 1.00 33.48 B
ATOM 3474 CE3 TRP 595 -21.560 188.382 93.302 1.00 33.48 B
ATOM 3475 CDl TRP 595 -23.025 191.681 93.095 1.00 33.48 B
ATOM 3476 NEl TRP 595 -23.539 191.028 92.008 1.00 33.48 B
ATOM 3477 CZ2 TRP 595 -23.270188.716 91.082 1.00 33.48 B
ATOM 3478 CZ3 TRP 595 -21.786 187.361 92.407 1.00 33.48 B
ATOM 3479 CH2 TRP 595 -22.631 187.533 91.311 1.00 33.48 B
ATOM 3480 C TRP 595 -20.394 192.783 96.544 1.00 33.48 B
ATOM 3481 O TRP 595 -20.782 192.047 97.443 1.00 33.48 B
ATOM 3482 N LYS 596 -19.512 193.755 96.736 1.00 33.48 B
ATOM 3483 CA LYS 596 -18.956 194.039 98.051 1.00 33.48 B
ATOM 3484 CB LYS 596 -17.743 194.942 97.924 1.00 33.48 B
ATOM 3485 CG LYS 596 -16.509 194.207 97.489 1.00 33.48 B
ATOM 3486 CD LYS 596 -16.065 193.254 98.572 1.00 33.48 B
ATOM 3487 CE LYS 596 -14.904192.418 98.116 1.00 33.48 B
ATOM 3488 NZ LYS 596 -15.281191.627 96.918 1.00 33.48 B
ATOM 3489 C LYS 596 -20.016 194.724 98.871 1.00 33.48 B
ATOM 3490 O LYS 596 -20.900 195.347 98.317 1.00 33.48 B
ATOM 3491 N GLU 597 -19.952 194.610 100.187 1.00 33.48 B
ATOM 3492 CA GLU 597 -20.965 195.259 100.995 1.00 33.48 B
ATOM 3493 CB GLU 597 -20.823 194.849 102.461 1.00 33.48 B
ATOM 3494 CG GLU 597 -22.119 194.972 103.246 1.00 33.48 B
ATOM 3495 CD GLU 597 -21.912 194.922 104.762 1.00 33.48 B
ATOM 3496 OEl GLU 597 -21.229 193.977 105.257 1.00 33.48 B
ATOM 3497 OE2 GLU 597 -22.446 195.835 105.456 1.00 33.48 B
ATOM 3498 C GLU 597 -20.795 196.778 100.842 1.00 33.48 B
ATOM 3499 O GLU 597 -21.763 197.517 100.653 1.00 33.48 B
ATOM 3500 N ARG 598 -19.543 197.224 100.908 1.00 33.48 B
ATOM 3501 CA ARG 598 -19.187 198.626 100.785 1.00 33.48 B
ATOM 3502 CB ARG 598 -17.854 198.902 101.480 1.00 33.48 B
ATOM 3503 CG ARG 598 -17.931198.883 102.976 1.00 33.48 B
ATOM 3504 CD ARG 598 -16.624 199.256 103.633 1.00 33.48 B
ATOM 3505 NE ARG 598 -16.687 198.884 105.047 1.00 33.48 B
ATOM 3506 CZ ARG 598 -17.419 199.514 105.970 1.00 33.48 B
ATOM 3507 NHl ARG 598 -18.155 200.576 105.637 1.00 33.48 B
ATOM 3508 NH2 ARG 598 -17.442 199.058 107.223 1.00 33.48 B
ATOM 3509 C ARG 598 -19.053 199.039 99.344 1.00 33.48 B
ATOM 3510 0 ARG 598 -18.309 198.429 98.580 1.00 33.48 B
ATOM 3511 N PRO 599 -19.765 200.094 98.949 1.00 33.48 B
ATOM 3512 CD PRO 599 -20.885 200.777 99.604 1.00 33.48 B
ATOM 3513 CA PRO 599 -19.649 200.519 97.561 1.00 33.48 B
ATOM 3514 CB PRO 599 -20.630 201.675 97.484 1.00 33.48 B ATOM 3515 CG PRO 599 -21.684 201.245 98.425 1.00 33.,48 B
ATOM 3516 C PRO 599 -18.221200.935 97.283 1.00 33. ,48 B
ATOM 3517 O PRO 599 -17.715 200.778 96.181 1.00 33. ,48 B
ATOM 3518 N GLU 600 -17.565 201.446 98.314 1.00 33. ,48 B
ATOM 3519 CA GLU 600 -16.194201.901 98.188 1.00 33. ,48 B
ATOM 3520 CB GLU 600 -15.768 202.643 99.445 1.00 33. ,48 B
ATOM 3521 CG GLU 600 -14.983 201.803 100.407 1.00 33, ,48 B
ATOM 3522 CD GLU 600 -14.638 202.568 101.663 1.00 33. ,48 B
ATOM 3523 OEl GLU 600 -15.544 202.712 102.525 1.00 33. ,48 B
ATOM 3524 OE2 GLU 600 -13.473 203.032 101.772 1.00 33. ,48 B
ATOM 3525 C GLU 600 -15.250 200.750 97.941 1.00 33. ,48 B
ATOM 3526 O GLU 600 -14.139 200.945 97.471 1.00 33. ,48 B
ATOM 3527 N ASP 601 -15.686199.547 98.274 1.00 33. ,48 B
ATOM 3528 CA ASP 601 -14.861198.383 98.045 1.00 33. .48 B
ATOM 3529 CB ASP 601 -15.158 197.306 99.081 1.00 33, .48 B
ATOM 3530 CG ASP 601 -14.681197.679 100.470 1.00 33, .48 B
ATOM 3531 ODl ASP 601 -13.722 198.472 100.591 1.00 33, .48 B
ATOM 3532 OD2 ASP 601 -15.259 197.154 101.447 1.00 33, .48 B
ATOM 3533 C ASP 601 -15.088 197.814 96.648 1.00 33, .48 B
ATOM 3534 0 ASP 601 -14.443 196.850 96.263 1.00 33, .48 B
ATOM 3535 N ARG 602 -15.986198.414 95.880 1.00 33, .48 B
ATOM 3536 CA ARG 602 -16.277 197.922 94.540 1.00 33, .48 B
ATOM 3537 CB ARG 602 -17.771198.029 94.249 1.00 33 .48 B
ATOM 3538 CG ARG 602 -18.628 197.534 95.365 1.00 33, .48 B
ATOM 3539 CD ARG 602 -20.075 197.674 95.034 1.00 33, .48 B
ATOM 3540 NE ARG 602 -20.864 197.510 96.238 1.00 33, .48 B
ATOM 3541 CZ ARG 602 -22.013 198.126 96.452 1.00 33, .48 B
ATOM 3542 NHl ARG 602 -22.504198.940 95.537 1.00 33, .48 B
ATOM 3543 NH2 ARG 602 -22.660197.945 97.586 1.00 33, .48 B
ATOM 3544 C ARG 602 -15.528 198.659 93.448 1.00 33, .48 B
ATOM 3545 0 ARG 602 -15.194199.826 93.587 1.00 33 .48 B
ATOM 3546 N PRO 603 -15.262 197.975 92.328 1.00 33 .48 B
ATOM 3547 CD PRO 603 -15.623 196.583 92.008 1.00 33 .48 B
ATOM 3548 CA PRO 603 -14.553 198.597 91.214 1.00 33 .48 B
ATOM 3549 CB PRO 603 -14.261197.415 90.304 1.00 33 .48 B
ATOM 3550 CG PRO 603 -15.445 196.546 90.519 1.00 33 .48 B
ATOM 3551 C PRO 603 -15.485 199.609 90.570 1.00 33 .48 B
ATOM 3552 0 PRO 603 -16.660199.675 90.912 1.00 33 .48 B
ATOM 3553 N ALA 604 -14.969 200.400 89.642 1.00 33 .48 B
ATOM 3554 CA ALA 604 -15.795 201.385 88.963 1.00 33 .48 B
ATOM 3555 CB ALA 604 -15.103 202.714 88.938 1.00 33 .48 B
ATOM 3556 C ALA 604 -16.002 200.876 87.556 1.00 33 .48 B
ATOM 3557 0 ALA 604 -15.188 200.111 87.052 1.00 33 .48 B
ATOM 3558 N PHE 605 -17.078 201.296 86.912 1.00 33 .48 B ATOM 3559 CA PHE 605 -17.331 200.815 85.576 1.00 33.,48 B
ATOM 3560 CB PHE 605 -18.588 201.472 85.017 1.00 33. ,48 B
ATOM 3561 CG PHE 605 -19.849 200.814 85.484 1.00 33. ,48 B
ATOM 3562 CDl PHE 605 -20.144 199.515 85.095 1.00 33. ,48 B
ATOM 3563 CD2 PHE 605 -20.692 201.449 86.379 1.00 33. .48 B
ATOM 3564 CEl PHE 605 -21.234 198.871 85.592 1.00 33, ,48 B
ATOM 3565 CE2 PHE 605 -21.792 200.796 86.880 1.00 33. ,48 B
ATOM 3566 CZ PHE 605 -22.061199.508 86.488 1.00 33. ,48 B
ATOM 3567 C PHE 605 -16.152 201.003 84.645 1.00 33. .48 B
ATOM 3568 O PHE 605 -15.990 200.263 83.685 1.00 33. .48 B
ATOM 3569 N SER 606 -15.311 201.985 84.923 1.00 33. .48 B
ATOM 3570 CA SER 606 -14.163 202.187 84.062 1.00 33, .48 B
ATOM 3571 CB SER 606 -13.593 203.595 84.247 1.00 33, .48 B
ATOM 3572 OG SER 606 -13.101203.775 85.552 1.00 33, .48 B
ATOM 3573 C SER 606 -13.111 201.118 84.389 1.00 33, .48 B
ATOM 3574 O SER 606 -12.312 200.739 83.529 1.00 33, .48 B
ATOM 3575 N ARG 607 -13.130 200.627 85.629 1.00 33, .48 B
ATOM 3576 CA ARG 607 -12.192 199.599 86.069 1.00 33, .48 B
ATOM 3577 CB ARG 607 -12.144 199.530 87.585 1.00 33, .48 B
ATOM 3578 CG ARG 607 -10.877 200.059 88.147 1.00 33, .48 B
ATOM 3579 CD ARG 607 -10.065 199.010 88.843 1.00 33, .48 B
ATOM 3580 NE ARG 607 -8.788 199.589 89.242 1.00 33, .48 B
ATOM 3581 CZ ARG 607 -7.920 198.987 90.046 1.00 33, .48 B
ATOM 3582 NHl ARG 607 -8.202 197.775 90.539 1.00 33, .48 B
ATOM 3583 NH2 ARG 607 -6.776 199.599 90.357 1.00 33, .48 B
ATOM 3584 C ARG 607 -12.583 198.234 85.539 1.00 33, .48 B
ATOM 3585 0 ARG 607 -11.755 197.519 84.973 1.00 33, .48 B
ATOM 3586 N LEU 608 -13.847 197.878 85.742 1.00 33, .48 B
ATOM 3587 CA LEU 608 -14.358 196.605 85.302 1.00 33 .48 B
ATOM 3588 CB LEU 608 -15.855 196.525 85.550 1.00 33 .48 B
ATOM 3589 CG LEU 608 -16.312 196.456 86.996 1.00 33, .48 B
ATOM 3590 CDl LEU 608 -17.748 196.855 87.045 1.00 33, .48 B
ATOM 3591 CD2 LEU 608 -16.114 195.073 87.562 1.00 33 .48 B
ATOM 3592 C LEU 608 -14.097 196.487 83.828 1.00 33 .48 B
ATOM 3593 0 LEU 608 -13.617 195.472 83.352 1.00 33, .48 B
ATOM 3594 N LEU 609 -14.407 197.544 83.103 1.00 33, .48 B
ATOM 3595 CA LEU 609 -14.222 197.539 81.671 1.00 33 .48 B
ATOM 3596 CB LEU 609 -14.633 198.898 81.102 1.00 33 .48 B
ATOM 3597 CG LEU 609 -14.425 199.146 79.610 1.00 33 .48 B
ATOM 3598 CDl LEU 609 -14.927 197.973 78.808 1.00 33, .48 B
ATOM 3599 CD2 LEU 609 -15.136 200.401 79.213 1.00 33 .48 B
ATOM 3600 C LEU 609 -12.792 197.218 81.286 1.00 33 .48 B
ATOM 3601 0 LEU 609 -12.541 196.458 80.362 1.00 33 .48 B
ATOM 3602 N ARG 610 -11.851197.808 82.005 1.00 33 .48 B ATOM 3603 CA ARG 610 -10.447 197.602 81.724 1.00 33.48 B
ATOM 3604 CB ARG 610 -9.632 198.657 82.479 1.00 33.48 B
ATOM 3605 CG ARG 610 -8.134 198.631 82.235 1.00 33.48 B
ATOM 3606 CD ARG 610 -7.523 200.036 82.313 1.00 33.48 B
ATOM 3607 NE ARG 610 -7.926 200.751 83.518 1.00 33.48 B
ATOM 3608 CZ ARG 610 -7.741 200.297 84.757 1.00 33.48 B
ATOM 3609 NHl ARG 610 -7.148 199.118 84.956 1.00 33.48 B
ATOM 3610 NH2 ARG 610 -8.163 201.012 85.800 1.00 33.48 B
ATOM 3611 C ARG 610 -10.025 196.180 82.088 1.00 33.48 B
ATOM 3612 O ARG 610 -9.163 195.606 81.433 1.00 33.48 B
ATOM 3613 N GLN 611 -10.643 195.609 83.122 1.00 33.48 B
ATOM 3614 CA GLN 611 -10.336 194.242 83.545 1.00 33.48 B
ATOM 3615 CB GLN 611 -10.925 193.960 84.926 1.00 33.48 B
ATOM 3616 CG GLN 611 -10.395 194.831 86.026 1.00 33.48 B
ATOM 3617 CD GLN 611 -11.006 194.503 87.370 1.00 33.48 B
ATOM 3618 OEl GLN 611 -12.218 194.433 87.519 1.00 33.48 B
ATOM 3619 NE2 GLN 611 -10.164 194.309 88.358 1.00 33.48 B
ATOM 3620 C GLN 611 -10.914 193.238 82.548 1.00 33.48 B
ATOM 3621 0 GLN 611 -10.228 192.347 82.073 1.00 33.48 B
ATOM 3622 N LEU 612 -12.194 193.384 82.251 1.00 33.48 B
ATOM 3623 CA LEU 612 -12.859 192.509 81.315 1.00 33.48 B
ATOM 3624 CB LEU 612 -14.308 192.953 81.136 1.00 33.48 B
ATOM 3625 CG LEU 612 -15.151 192.946 82.407 1.00 33.48 B
ATOM 3626 CDl LEU 612 -16.587 193.310 82.091 1.00 33.48 B
ATOM 3627 CD2 LEU 612 -15.082 191.569 83.032 1.00 33.48 B
ATOM 3628 C LEU 612 -12.141 192.547 79.977 1.00 33.48 B
ATOM 3629 0 LEU 612 -11.855 191.514 79.384 1.00 33.48 B
ATOM 3630 N ALA 613 -11.846 193.747 79.501 1.00 33.48 B
ATOM 3631 CA ALA 613 -11.174193.908 78.224 1.00 33.48 B
ATOM 3632 CB ALA 613 -10.927 195.374 77.952 1.00 33.48 B
ATOM 3633 C ALA 613 -9.865 193.148 78.178 1.00 33.48 B
ATOM 3634 0 ALA 613 -9.383 192.812 77.103 1.00 33.48 B
ATOM 3635 N GLU 614 -9.283 192.887 79.343 1.00 33.48 B
ATOM 3636 CA GLU 614 -8.025 192.155 79.420 1.00 33.48 B
ATOM 3637 CB GLU 614 -7.367 192.390 80.784 1.00 33.48 B
ATOM 3638 CG GLU 614 -5.975 191.779 80.958 1.00 33.48 B
ATOM 3639 CD GLU 614 -5.997 190.265 81.249 1.00 33.48 B
ATOM 3640 OEl GLU 614 -4.902 189.650 81.325 1.00 33.48 B
ATOM 3641 OE2 GLU 614 -7.103 189.690 81.405 00 33.48 B
ATOM 3642 C GLU 614 -8.313 190.668 79.197 00 33.48 B
ATOM 3643 0 GLU 614 -7.641190.001 78.405 00 33.48 B
ATOM 3644 N ILE 615 -9.323 190.154 79.894 00 33 .48 B
ATOM 3645 CA ILE 615 -9.722 188.754 79.757 00 33.48 B
ATOM 3646 CB ILE 615 -11.048 188.468 80.515 1.00 33 .48 B ATOM 3647 CG2 ILE 615 -11.685 187.215 79.999 1.00 33.48 B
ATOM 3648 CGl ILE 615 -10.770 188.320 82.007 1.00 33.48 B
ATOM 3649 CDl ILE 615 -11.960 187.915 82.801 1.00 33.48 B
ATOM 3650 C ILE 615 -9.892 188.419 78.275 1.00 33.48 B
ATOM 3651 O ILE 615 -9.291187.471 77.765 1.00 33.48 B
ATOM 3652 N ALA 616 -10.711189.207 77.590 1.00 33.48 B
ATOM 3653 CA ALA 616 -10.920 189.004 76.167 1.00 33.48 B
ATOM 3654 CB ALA 616 -11.541 190.241 75.554 1.00 33.48 B
ATOM 3655 C ALA 616 -9.560 188.738 75.531 1.00 33.48 B
ATOM 3656 O ALA 616 -9.316 187.674 74.964 1.00 33.48 B
ATOM 3657 N GLU 617 -8.670 189.712 75.637 1.00 33.48 B
ATOM 3658 CA GLU 617 -7.338 189.580 75.076 1.00 33.48 B
ATOM 3659 CB GLU 617 -6.631190.947 75.062 1.00 33.48 B
ATOM 3660 CG GLU 617 -5.334 190.994 74.249 1.00 33.48 B
ATOM 3661 CD GLU 617 -5.574 191.265 72.766 1.00 33.48 B
ATOM 3662 OEl GLU 617 -4.935 190.586 71.919 1.00 33.48 B
ATOM 3663 OE2 GLU 617 -6.388 192.170 72.457 1.00 33.48 B
ATOM 3664 C GLU 617 -6.577 188.610 75.964 1.00 33.48 B
ATOM 3665 O GLU 617 -5.644 189.005 76.665 1.00 33.48 B
ATOM 3666 N SER 618 -6.992 187.347 75.935 1.00 33.48 B
ATOM 3667 CA SER 618 -6.372 186.285 76.727 1.00 33.48 B
ATOM 3668 CB SER 618 -5.846 186.835 78.053 1.00 33.48 B
ATOM 3669 OG SER 618 -6.858 187.557 78.736 1.00 33.48 B
ATOM 3670 C SER 618 -7.371185.169 77.011 1.00 33.48 B
ATOM 3671 O SER 618 -8.317 184.980 76.211 1.00 33.48 B
ATOM 3672 OXT SER 618 -7.189 184.486 78.039 1.00 33.48 B
TER 3673 SER 618 B
ATOM 3674 C GLY 351 2.995 197.694 35.116 1.00 33.48 C
ATOM 3675 O GLY 351 2.291196.760 34.702 1.00 33.48 C
ATOM 3676 N GLY 351 4.146 196.127 36.684 1.00 33.48 c
ATOM 3677 CA GLY 351 4.266 197.402 35.893 1.00 33.48 c
ATOM 3678 N SER 352 2.671198.971 34.923 1.00 33.48 c
ATOM 3679 CA SER 352 1.455 199.303 34.179 1.00 33.48 c
ATOM 3680 CB SER 352 1.008 200.736 34.486 1.00 33.48 c
ATOM 3681 OG SER 352 -0.339 200.946 34.086 1.00 33.48 c
ATOM 3682 C SER 352 1.761199.165 32.695 1.00 33.48 c
ATOM 3683 O SER 352 2.924 199.195 32.282 1.00 33.48 c
ATOM 3684 N MET 353 0.726 198.999 31.889 1.00 33.48 c
ATOM 3685 CA MET 353 0.935 198.868 30.456 1.00 33.48 c
ATOM 3686 CB MET 353 -0.383 198.486 29.778 1.00 33.48 c
ATOM 3687 CG MET 353 -0.265 198.295 28.288 1.00 33.48 c
ATOM 3688 SD MET 353 -1.777 197.701 27.535 1.00 33.48 c
ATOM 3689 CE MET 353 -2.556 199.295 26.886 1.00 33.48 c
ATOM 3690 C MET 353 1.447 200.207 29.916 1.00 33.48 c ATOM 3691 O MET 353 1.946 200.309 28.791 1.00 33.48 C
ATOM 3692 N GLY 354 1.336 201.231 30.753 1.00 33.48 C
ATOM 3693 CA GLY 354 1.745 202.567 30.370 1.00 33.48 C
ATOM 3694 C GLY 354 3.109 202.647 29.736 1.00 33.48 C
ATOM 3695 O GLY 354 3.245 203.186 28.639 1.00 33.48 C
ATOM 3696 N LYS 355 4.109 202.104 30.421 1.00 33.48 C
ATOM 3697 CA LYS 355 5.484 202.133 29.941 1.00 33.48 C
ATOM 3698 CB LYS 355 6.409 201.697 31.063 1.00 33.48 C
ATOM 3699 CG LYS 355 6.102 200.310 31.563 1.00 33.48 C
ATOM 3700 CD LYS 355 6.785 200.065 32.882 1.00 33.48 c
ATOM 3701 CE LYS 355 6.143 198.906 33.608 1.00 33.48 c
ATOM 3702 NZ LYS 355 6.720 198.782 34.975 1.00 33.48 c
ATOM 3703 C LYS 355 5.816 201.313 28.693 1.00 33.48 c
ATOM 3704 0 LYS 355 6.954 201.297 28.262 1.00 33.48 c
ATOM 3705 N TRP 356 4.844 200.636 28.103 1.00 33.48 c
ATOM 3706 CA TRP 356 5.140 199.835 26.920 1.00 33.48 c
ATOM 3707 CB TRP 356 4.743 198.365 27.130 1.00 33.48 c
ATOM 3708 CG TRP 356 5.393 197.711 28.286 1.00 33.48 c
ATOM 3709 CD2 TRP 356 6.710 197.167 28.322 1.00 33.48 c
ATOM 3710 CE2 TRP 356 6.907 196.629 29.620 1.00 33.48 c
ATOM 3711 CE3 TRP 356 7.749 197.083 27.386 1.00 33.48 c
ATOM 3712 CDl TRP 356 4.854 197.499 29.521 1.00 33.48 c
ATOM 3713 NEl TRP 356 5.759 196.843 30.332 1.00 33.48 c
ATOM 3714 CZ2 TRP 356 8.095 196.018 30.003 1.00 33.48 c
ATOM 3715 CZ3 TRP 356 8.930 196.477 27.766 1.00 33.48 c
ATOM 3716 CH2 TRP 356 9.096 195.950 29.067 1.00 33.48 c
ATOM 3717 C TRP 356 4.416 200.346 25.699 1.00 33.48 c
ATOM 3718 0 TRP 356 4.532 199.769 24.625 1.00 33.48 c
ATOM 3719 N VAL 357 3.659 201.420 25.853 1.00 33.48 c
ATOM 3720 CA VAL 357 2.918 201.925 24.717 1.00 33.48 c
ATOM 3721 CB VAL 357 1.752 202.782 25.158 1.00 33.48 c
ATOM 3722 CGl VAL 357 1.019 203.291 23.947 1.00 33.48 c
ATOM 3723 CG2 VAL 357 0.820 201.956 26.009 1.00 33.48 c
ATOM 3724 C VAL 357 3.757 202.684 23.712 1.00 33.48 c
ATOM 3725 0 VAL 357 4.526 203.564 24.052 1.00 33.48 c
ATOM 3726 N ILE 358 3.595 202.312 22.456 1.00 33.48 c
ATOM 3727 CA ILE 358 4.334 202.922 21.379 1.00 33.48 c
ATOM 3728 CB ILE 358 5.089 201.844 20.554 1.00 33.48 c
ATOM 3729 CG2 ILE 358 5.629 202.449 19.270 1.00 33.48 c
ATOM 3730 CGl ILE 358 6.205 201.218 21.397 1.00 33.48 c
ATOM 3731 CDl ILE 358 7.089 200.252 20.630 1.00 33.48 c
ATOM 3732 C ILE 358 3.323 203.647 20.504 1.00 33.48 c
ATOM 3733 0 ILE 358 2.241 203.133 20.223 1.00 33.48 c
ATOM 3734 N ASP 359 3.677 204.856 20.098 1.00 33.48 c ATOM 3735 CA ASP 359 2.806205.661 19.270 1.00 33.48 C
ATOM 3736 CB ASP 359 3.288 207.116 19.267 1.00 33.48 C
ATOM 3737 CG ASP 359 2.436 208.029 18.379 1.00 33.48 C
ATOM 3738 ODl ASP 359 1.471 207.544 17.713 1.00 33.48 C
ATOM 3739 OD2 ASP 359 2.748 209.251 18.354 1.00 33.48 C
ATOM 3740 C ASP 359 2.787 205.100 17.858 1.00 33.48 C
ATOM 3741 O ASP 359 3.743 205.232 17.104 1.00 33.48 C
ATOM 3742 N PRO 360 1.676 204.478 17.480 1.00 33.48 C
ATOM 3743 CD PRO 360 0.405 204.426 18.216 1.00 33.48 C
ATOM 3744 CA PRO 360 1.531 203.896 16.152 1.00 33.48 c
ATOM 3745 CB PRO 360 0.028 203.781 16.002 1.00 33.48 c
ATOM 3746 CG PRO 360 0.400 203.466 17.386 1.00 33.48 c
ATOM 3747 C PRO 360 2.162 204.712 15.030 1.00 33.48 c
ATOM 3748 O PRO 360 2.655 204.144 14.057 1.00 33.48 c
ATOM 3749 N SER 361 2.168 206.034 15.158 1.00 33.48 c
ATOM 3750 CA SER 361 2.729 206.868 14.096 1.00 33.48 c
ATOM 3751 CB SER 361 2.222 208.312 14.226 1.00 33.48 c
ATOM 3752 OG SER 361 2.768 208.982 15.354 1.00 33.48 c
ATOM 3753 C SER 361 4.255 206.867 14.035 1.00 33.48 c
ATOM 3754 0 SER 361 4.842 207.113 12.988 1.00 33.48 c
ATOM 3755 N GLU 362 4.891 206.575 15.159 1.00 33.48 c
ATOM 3756 CA GLU 362 6.345 206.576 15.233 1.00 33.48 c
ATOM 3757 CB GLU 362 6.773 206.718 16.686 1.00 33.48 c
ATOM 3758 CG GLU 362 5.920 207.698 17.463 1.00 33.48 c
ATOM 3759 CD GLU 362 6.339 207.809 18.909 1.00 33.48 c
ATOM 3760 OEl GLU 362 6.268 206.776 19.638 1.00 33.48 c
ATOM 3761 OE2 GLU 362 6.742 208.935 19.298 1.00 33.48 c
ATOM 3762 C GLU 362 6.959 205.312 14.659 1.00 33.48 c
ATOM 3763 O GLU 362 8.177 205.235 14.466 1.00 33.48 c
ATOM 3764 N LEU 363 6.106 204.319 14.411 1.00 33.48 c
ATOM 3765 CA LEU 363 6.540 203.039 13.867 1.00 33.48 c
ATOM 3766 CB LEU 363 5.678 201.901 14.395 1.00 33.48 c
ATOM 3767 CG LEU 363 6.337 200.931 15.359 1.00 33.48 c
ATOM 3768 CDl LEU 363 5.611 199.598 15.263 1.00 33.48 c
ATOM 3769 CD2 LEU 363 7.795 200.761 15.015 1.00 33.48 c
ATOM 3770 C LEU 363 6.445 203.041 12.367 1.00 33.48 c
ATOM 3771 O LEU 363 5.508 203.595 11.804 1.00 33.48 c
ATOM 3772 N THR 364 7.413 202.417 11.715 1.00 33.48 c
ATOM 3773 CA THR 364 7.387 202.356 10.269 1.00 33.48 c
ATOM 3774 CB THR 364 8.291 203.472 9.657 1.00 33.48 c
ATOM 3775 OGl THR 364 9.238 202.913 8.748 1.00 33.48 c
ATOM 3776 CG2 THR 364 8.986 204.232 10.745 1.00 33.48 c
ATOM 3777 C THR 364 7.764 200.960 9.787 1.00 33.48 c
ATOM 3778 O THR 364 8.786 200.403 10.175 1.00 33.48 c ATOM 3779 N PHE 365 6.895 200.384 8.967 1.00 33 .48 C
ATOM 3780 CA PHE 365 7.104 199.048 8.442 1.00 33.48 C
ATOM 3781 CB PHE 365 5.766 198.351 8.237 1.00 33 .48 C
ATOM 3782 CG PHE 365 4.999 198.128 9.501 1.00 33 .48 C
ATOM 3783 CDl PHE 365 4.497 196.883 9.800 1.00 33 .48 C
ATOM 3784 CD2 PHE 365 4.764 199.167 10.382 1.00 33 .48 C
ATOM 3785 CEl PHE 365 3.782 196.682 10.944 1.00 33 .48 C
ATOM 3786 CE2 PHE 365 4.043 198.967 11.535 1.00 33 .48 C
ATOM 3787 CZ PHE 365 3.553 197.729 11.815 1.00 33 .48 C
ATOM 3788 C PHE 365 7.816 199.128 7.121 1.00 33 .48 C
ATOM 3789 0 PHE 365 7.416 199.884 6.246 1.00 33 .48 C
ATOM 3790 N VAL 366 8.864 198.331 6.961 1.00 33 .48 C
ATOM 3791 CA VAL 366 9.616 198.351 5.721 1.00 33 .48 C
ATOM 3792 CB VAL 366 11.098 198.569 5.997 1.00 33 .48 C
ATOM 3793 CGl VAL 366 11.846 198.703 4.691 1.00 33 .48 C
ATOM 3794 CG2 VAL 366 11.279 199.798 6.847 1.00 33 .48 c
ATOM 3795 C VAL 366 9.440 197.108 4.851 1.00 33 .48 c
ATOM 3796 0 VAL 366 9.290 197.221 3.636 1.00 33 .48 c
ATOM 3797 N GLN 367 9.471 195.928 5.464 1.00 33 .48 c
ATOM 3798 CA GLN 367 9.311 194.671 4.728 1.00 33 .48 c
ATOM 3799 CB GLN 367 10.637 194.260 4.091 1.00 33 .48 c
ATOM 3800 CG GLN 367 11.844 194.385 5.012 1.00 33 .48 c
ATOM 3801 CD GLN 367 13.153 194.071 4.294 1.00 33 .48 c
ATOM 3802 OEl GLN 367 13.377 192.946 3.872 1.00 33 .48 c
ATOM 3803 NE2 GLN 367 14.009 195.067 4.147 1.00 33 .48 c
ATOM 3804 C GLN 367 8.786 193.517 5.565 1.00 33 .48 c
ATOM 3805 0 GLN 367 9.001 193.447 6.771 1.00 33 .48 c
ATOM 3806 N GLU 368 8.071 192.613 4.913 1.00 33 .48 c
ATOM 3807 CA GLU 368 7.545 191.439 5.597 1.00 33 .48 c
ATOM 3808 CB GLU 368 6.341 190.874 4.846 1.00 33 .48 c
ATOM 3809 CG GLU 368 5.589 189.795 5.612 1.00 33 .48 c
ATOM 3810 CD GLU 368 4.365 189.284 4.870 1.00 33 .48 c
ATOM 3811 OEl GLU 368 4.521 188.685 3.780 1.00 33 .48 c
ATOM 3812 OE2 GLU 368 3.245 189.485 5.377 1.00 33 .48 c
ATOM 3813 C GLU 368 8.681 190.445 5.563 1.00 33 .48 c
ATOM 3814 0 GLU 368 9.268 190.236 4.511 1.00 33 .48 c
ATOM 3815 N ILE 369 9.019 189.857 6.703 1.00 33 .48 c
ATOM 3816 CA ILE 369 10.108 188.892 6.712 1.00 33 .48 c
ATOM 3817 CB ILE 369 11.327 189.417 7.505 1.00 33 .48 c
ATOM 3818 CG2 ILE 369 11.924 190.628 6.792 1.00 33 .48 c
ATOM 3819 CGl ILE 369 10.934 189.733 8.944 1.00 33 .48 c
ATOM 3820 CDl ILE 369 12.071 190.302 9.738 1.00 33 .48 c
ATOM 3821 C ILE 369 9.765 187.494 7.219 1.00 33 .48 c
ATOM 3822 0 ILE 369 10.566 186.580 7.077 1.00 33 .48 c ATOM 3823 N GLY 370 8.579 187.320 7.790 1.00 33.48 C
ATOM 3824 CA GLY 370 8.192 186.014 8.293 1.00 33.48 C
ATOM 3825 c GLY 370 6.693 185.814 8.342 1.00 33.48 C
ATOM 3826 O GLY 370 5.940 186.777 8.327 1.00 33.48 C
ATOM 3827 N SER 371 6.255 184.559 8.388 1.00 33.48 C
ATOM 3828 CA SER 371 4.830 184.247 8.450 1.00 33.48 C
ATOM 3829 CB SER 371 4.341 183.761 7.096 1.00 33.48 C
ATOM 3830 OG SER 371 4.526 184.772 6.129 1.00 33.48 C
ATOM 3831 C SER 371 4.525 183.209 9.523 1.00 33.48 C
ATOM 3832 O SER 371 5.279 183.065 10.491 1.00 33.48 C
ATOM 3833 N GLY 372 3.415 182.496 9.366 1.00 33.48 C
ATOM 3834 CA GLY 372 3.050 181.495 10.352 1.00 33.48 C
ATOM 3835 C GLY 372 1.556 181.456 10.622 1.00 33.48 C
ATOM 3836 O GLY 372 0.826 182.364 10.224 1.00 33.48 c
ATOM 3837 N GLN 373 1.103 180.401 11.300 1.00 33.48 c
ATOM 3838 CA GLN 373 0.309 180.240 11.623 1.00 33.48 c
ATOM 3839 CB GLN 373 0.485 179.140 12.671 1.00 33.48 c
ATOM 3840 CG GLN 373 0.060 177.749 12.214 1.00 33.48 c
ATOM 3841 CD GLN 373 0.120 176.711 13.334 1.00 33.48 c
ATOM 3842 OEl GLN 373 0.135 175.512 13.108 1.00 33.48 c
ATOM 3843 NE2 GLN 373 0.450 177.163 14.551 1.00 33.48 c
ATOM 3844 C GLN 373 0.870 181.557 12.151 1.00 33.48 c
ATOM 3845 O GLN 373 1.793 182.125 11.578 1.00 33.48 c
ATOM 3846 N PHE 374 0.274 182.027 13.245 1.00 33.48 c
ATOM 3847 CA PHE 374 0.618 183.283 13.924 1.00 33.48 c
ATOM 3848 CB PHE 374 0.285 183.481 15.151 1.00 33.48 c
ATOM 3849 CG PHE 374 1.760 183.260 14.875 1.00 33.48 c
ATOM 3850 CDl PHE 374 2.705 183.589 15.842 1.00 33.48 c
ATOM 3851 CD2 PHE 374 2.196 182.652 13.684 1.00 33.48 c
ATOM 3852 CEl PHE 374 4.054 183.313 15.641 1.00 33.48 c
ATOM 3853 CE2 PHE 374 3.538 182.368 13.466 1.00 33.48 c
ATOM 3854 CZ PHE 374 4.477 182.695 14.446 1.00 33.48 c
ATOM 3855 C PHE 374 0.518 184.541 13.063 1.00 33.48 c
ATOM 3856 O PHE 374 1.466 184.936 12.384 1.00 33.48 c
ATOM 3857 N GLY 375 0.639 185.187 13.104 1.00 33.48 c
ATOM 3858 CA GLY 375 0.795 186.406 12.339 1.00 33.48 c
ATOM 3859 C GLY 375 2.085 186.612 11.575 1.00 33.48 c
ATOM 3860 0 GLY 375 2.987 185.766 11.586 1.00 33.48 c
ATOM 3861 N LEU 376 2.155 187.769 10.919 1.00 33.48 c
ATOM 3862 CA LEU 376 3.298 188.167 10.121 1.00 33.48 c
ATOM 3863 CB LEU 376 2.835 189.094 9.009 1.00 33.48 c
ATOM 3864 CG LEU 376 1.603 188.610 8.237 1.00 33.48 c
ATOM 3865 CDl LEU 376 0.967 189.757 7.446 1.00 33.48 c
ATOM 3866 CD2 LEU 376 2.019 187.484 7.323 1.00 33.48 c ATOM 3867 C LEU 376 4.332 188.882 10.968 1.00 33.48 c
ATOM 3868 O LEU 376 4.058 189.303 12.081 1.00 33.48 c
ATOM 3869 N VAL 377 5.530 188.995 10.417 1.00 33.48 c
ATOM 3870 CA VAL 377 6.631 189.677 11.064 1.00 33.48 c
ATOM 3871 CB VAL 377 7.683 188.704 11.612 1.00 33.48 c
ATOM 3872 CGl VAL 377 8.979 189.437 11.883 1.00 33.48 c
ATOM 3873 CG2 VAL 377 7.181188.088 12.903 1.00 33.48 c
ATOM 3874 C VAL 377 7.261 190.571 10.014 1.00 33.48 c
ATOM 3875 O VAL 377 7.637 190.115 8.929 1.00 33.48 c
ATOM 3876 N HIS 378 7.331 191.860 10.340 1.00 33.48 c
ATOM 3877 CA HIS 378 7.880 192.858 9.444 1.00 33.48 c
ATOM 3878 CB HIS 378 6.883 193.999 9.216 1.00 33.48 c
ATOM 3879 CG HIS 378 5.735 193.644 8.323 1.00 33.48 c
ATOM 3880 CD2 HIS 378 5.466 193.992 7.043 1.00 33.48 c
ATOM 3881 NDl HIS 378 4.722 192.795 8.711 1.00 33.48 c
ATOM 3882 CEl HIS 378 3.883 192.627 7.705 1.00 33.48 c
ATOM 3883 NE2 HIS 378 4.312 193.341 6.681 1.00 33.48 c
ATOM 3884 C HIS 378 9.112 193.430 10.070 1.00 33.48 c
ATOM 3885 0 HIS 378 9.255 193.424 11.287 1.00 33.48 c
ATOM 3886 N LEU 379 9.997 193.928 9.222 1.00 33.48 c
ATOM 3887 CA LEU 379 11.226 194.551 9.666 1.00 33.48 c
ATOM 3888 CB LEU 379 12.388 194.069 8.801 1.00 33.48 c
ATOM 3889 CG LEU 379 13.821 194.475 9.129 1.00 33.48 c
ATOM 3890 CDl LEU 379 14.273 195.558 8.200 1.00 33.48 c
ATOM 3891 CD2 LEU 379 13.916 194.904 10.559 1.00 33.48 c
ATOM 3892 C LEU 379 11.024 196.049 9.498 1.00 33.48 c
ATOM 3893 0 LEU 379 10.645 196.511 8.427 1.00 33.48 c
ATOM 3894 N GLY 380 11.255 196.805 10.565 1.00 33.48 c
ATOM 3895 CA GLY 380 11.099 198.247 10.483 1.00 33.48 c
ATOM 3896 C GLY 380 11.899 199.005 11.518 1.00 33.48 c
ATOM 3897 0 GLY 380 12.870 198.494 12.059 1.00 33.48 c
ATOM 3898 N TYR 381 11.508 200.245 11.778 1.00 33.48 c
ATOM 3899 CA TYR 381 12.200 201.038 12.778 1.00 33.48 c
ATOM 3900 CB TYR 381 13.304 201.897 12.138 1.00 33.48 c
ATOM 3901 CG TYR 381 12.904 202.674 10.913 1.00 33.48 c
ATOM 3902 CDl TYR 381 13.139 202.174 9.642 1.00 33.48 c
ATOM 3903 CEl TYR 381 12.762 202.879 8.520 1.00 33.48 c
ATOM 3904 CD2 TYR 381 12.283 203.908 11.027 1.00 33.48 c
ATOM 3905 CE2 TYR 381 11.904204.616 9.913 1.00 33.48 c
ATOM 3906 CZ TYR 381 12.141204.098 8.665 1.00 33.48 c
ATOM 3907 OH TYR 381 11.729 204.805 7.565 1.00 33.48 c
ATOM 3908 C TYR 381 11.231 201.884 13.602 1.00 33.48 c
ATOM 3909 0 TYR 381 10.086 202.077 13.216 1.00 33.48 c
ATOM 3910 N TRP 382 11.709 202.368 14.743 1.00 33.48 c ATOM 3911 CA TRP 382 10.907 203.140 15.680 1.00 33.48 C
ATOM 3912 CB TRP 382 10.480 202.198 16.797 1.00 33 .48 C
ATOM 3913 CG TRP 382 9.935 202.837 18.012 1.00 33 .48 C
ATOM 3914 CD2 TRP 382 10.294 202.539 19.364 1.00 33 .48 C
ATOM 3915 CE2 TRP 382 9.463 203.310 20.192 1. 00 33 .48 C
ATOM 3916 CE3 TRP 382 11.240 201.688 19.956 1.00 33 .48 C
ATOM 3917 CDl TRP 382 8.942 203.747 18.071 1.00 33 .48 C
ATOM 3918 NEl TRP 382 8.647 204.039 19.375 1.00 33 .48 C
ATOM 3919 CZ2 TRP 382 9.538 203.264 21.583 1.00 33 .48 C
ATOM 3920 CZ3 TRP 382 11.317 201.639 21.348 1.00 33 .48 C
ATOM 3921 CH2 TRP 382 10.465 202.427 22.144 1. 00 33 .48 C
ATOM 3922 C TRP 382 11.680 204.316 16.253 1.00 33 .48 C
ATOM 3923 O TRP 382 12.773 204.138 16.788 1.00 33 .48 C
ATOM 3924 N LEU 383 11.108 205.512 16.147 1.00 33 .48 C
ATOM 3925 CA LEU 383 11.732 206.751 16.644 1.00 33 .48 C
ATOM 3926 CB LEU 383 11.919 206.672 18.163 1.00 33 .48 C
ATOM 3927 CG LEU 383 10.601 206.551 18.923 1.00 33 .48 C
ATOM 3928 CDl LEU 383 10.816 206.690 20.410 1.00 33 .48 C
ATOM 3929 CD2 LEU 383 9.657 207.609 18.433 1.00 33.48 c
ATOM 3930 C LEU 383 13.054 207.167 15.966 1.00 33 .48 c
ATOM 3931 O LEU 383 13.528 208.274 16.148 1.00 33 .48 c
ATOM 3932 N ASN 384 13.633 206.272 15.180 1.00 33 .48 c
ATOM 3933 CA ASN 384 14.871 206.527 14.458 1.00 33 .48 c
ATOM 3934 CB ASN 384 16.017 206.790 15.431 1.00 33 .48 c
ATOM 3935 CG ASN 384 16.167 205.702 16.434 1.00 33 .48 c
ATOM 3936 ODl ASN 384 16.139 204.543 16.075 1.00 33 .48 c
ATOM 3937 ND2 ASN 384 16.329 206.058 17.698 1.00 33 .48 c
ATOM 3938 C ASN 384 15.165 205.304 13.581 1.00 33 .48 c
ATOM 3939 O ASN 384 14.369 204.381 13.541 1.00 33 .48 c
ATOM 3940 N LYS 385 16.302 205.299 12.894 1.00 33 .48 c
ATOM 3941 CA LYS 385 16.676 204.219 11.984 1.00 33 .48 c
ATOM 3942 CB LYS 385 17.866 204.658 11.144 1.00 33 .48 c
ATOM 3943 CG LYS 385 17.576 205.837 10.282 1.00 33.48 c
ATOM 3944 CD LYS 385 16.261205.639 9.582 1.00 33 .48 c
ATOM 3945 CE LYS 385 15.958 206.778 8.656 1.00 33.48 c
ATOM 3946 NZ LYS 385 14.618 206.584 8.070 1.00 33 .48 c
ATOM 3947 C LYS 385 16.964 202.828 12.548 1.00 33 .48 c
ATOM 3948 O LYS 385 17.021 201.854 11.791 1. 00 33 .48 c
ATOM 3949 N ASP 386 17.164 202.731 13.861 1.00 33 .48 c
ATOM 3950 CA ASP 386 17.429 201.441 14.487 1.00 33 .48 c
ATOM 3951 CB ASP 386 17.399 201.559 16.014 1.00 33 .48 c
ATOM 3952 CG ASP 386 18.556 202.365 16.565 1.00 33 .48 c
ATOM 3953 ODl ASP 386 18.645 202.522 17.797 1.00 33 .48 c
ATOM 3954 OD2 ASP 386 19.382 202.839 15.771 1.00 33 .48 c ATOM 3955 C ASP 386 16.348 200.478 14.034 1.00 33.48 C
ATOM 3956 0 ASP 386 15.159 200.735 14.253 1.00 33.48 C
ATOM 3957 N LYS 387 16.758 199.380 13.396 1.00 33.48 C
ATOM 3958 CA LYS 387 15.813 198.374 12.914 1.00 33.48 C
ATOM 3959 CB LYS 387 16.480 197.369 11.999 1.00 33.48 C
ATOM 3960 CG LYS 387 17.197 197.986 10.873 1.00 33.48 C
ATOM 3961 CD LYS 387 17.713 196.936 9.959 1.00 33.48 C
ATOM 3962 CE LYS 387 18.443 197.575 8.824 1.00 33.48 C
ATOM 3963 NZ LYS 387 18.562 196.559 7.764 1.00 33.48 C
ATOM 3964 C LYS 387 15.209 197.606 14.050 1.00 33.48 C
ATOM 3965 0 LYS 387 15.880 197.265 15.017 1.00 33.48 C
ATOM 3966 N VAL 388 13.930 197.314 13.902 1.00 33.48 C
ATOM 3967 CA VAL 388 13.193 196.569 14.893 1.00 33.48 c
ATOM 3968 CB VAL 388 12.304 197.513 15.715 1.00 33.48 c
ATOM 3969 CGl VAL 388 13.177 198.523 16.429 1.00 33.48 c
ATOM 3970 CG2 VAL 388 11.307 198.230 14.802 1.00 33.48 c
ATOM 3971 C VAL 388 12.345 195.520 14.201 1.00 33.48 c
ATOM 3972 0 VAL 388 12.136 195.567 12.991 1.00 33.48 c
ATOM 3973 N ALA 389 11.865 194.566 14.979 1.00 33.48 c
ATOM 3974 CA ALA 389 11.032 193.506 14.435 1.00 33.48 c
ATOM 3975 CB ALA 389 11.549 192.155 14.890 1.00 33.48 c
ATOM 3976 C ALA 389 9.614 193.716 14.926 1.00 33.48 c
ATOM 3977 0 ALA 389 9.387 193.870 16.122 1.00 33.48 c
ATOM 3978 N ILE 390 8.664 193.726 14.005 1.00 33.48 c
ATOM 3979 CA ILE 390 7.285 193.927 14.383 1.00 33.48 c
ATOM 3980 CB ILE 390 6.698 195.165 13.675 1.00 33.48 c
ATOM 3981 CG2 ILE 390 5.544 195.703 14.460 1.00 33.48 c
ATOM 3982 CGl ILE 390 7.750 196.261 13.576 1.00 33.48 c
ATOM 3983 CDl ILE 390 7.377 197.372 12.632 1.00 33.48 c
ATOM 3984 C ILE 390 6.444 192.703 14.028 1.00 33.48 c
ATOM 3985 0 ILE 390 6.403 192.273 12.875 1.00 33.48 c
ATOM 3986 N LYS 391 5.773 192.161 15.040 1.00 33.48 c
ATOM 3987 CA LYS 391 4.907 190.998 14.906 1.00 33.48 c
ATOM 3988 CB LYS 391 5.109 190.080 16.119 1.00 33.48 c
ATOM 3989 CG LYS 391 4.769 188.596 15.924 1.00 33.48 c
ATOM 3990 CD LYS 391 4.973 187.834 17.255 1.00 33.48 c
ATOM 3991 CE LYS 391 4.822 186.307 17.137 1.00 33.48 c
ATOM 3992 NZ LYS 391 5.960 185.627 16.411 1.00 33.48 c
ATOM 3993 C LYS 391 3.458 191.486 14.843 1.00 33.48 c
ATOM 3994 0 LYS 391 3.075 192.394 15.573 1.00 33.48 c
ATOM 3995 N THR 392 2.658 190.879 13.972 1.00 33.48 c
ATOM 3996 CA THR 392 1.258 191.255 13.802 1.00 33 .48 c
ATOM 3997 CB THR 392 1.073 192.168 12.611 1.00 33.48 c
ATOM 3998 OGl THR 392 1.572 191.497 11.449 1.00 33.48 c ATOM 3999 CG2 THR 392 1.816 193.476 12.805 1.00 33.48 C
ATOM 4000 C THR 392 0.407 190.049 13.501 1.00 33 .48 c
ATOM 4001 0 THR 392 0.847 189.159 12.799 1.00 33.48 c
ATOM 4002 N ILE 393 -0.821 190.041 14.005 1.00 33 .48 c
ATOM 4003 CA ILE 393 -1.761 188.949 13.766 1.00 33 .48 c
ATOM 4004 CB ILE 393 -3.138 189.283 14.327 1.00 33 .48 c
ATOM 4005 CG2 ILE 393 -4.128 188.187 13.953 1.00 33 .48 c
ATOM 4006 CGl ILE 393 -3.049 189.473 15.842 1.00 33 .48 c
ATOM 4007 CDl ILE 393 -4.270 190.138 16.436 1.00 33.48 c
ATOM 4008 C ILE 393 -1.910 188.746 12.268 1.00 33 .48 c
ATOM 4009 0 ILE 393 -1.635 189.653 11.481 1.00 33 .48 c
ATOM 4010 N ARG 394 -2.372 187.572 11.868 1.00 33.48 c
ATOM 4011 CA ARG 394 -2.507 187.289 10.449 1.00 33 .48 c
ATOM 4012 CB ARG 394 -1.258 186.514 9.984 1.00 33 .48 c
ATOM 4013 CG ARG 394 -1.076 186.373 8.471 1.00 33.48 c
ATOM 4014 CD ARG 394 -1.890 185.227 7.877 1.00 33.48 c
ATOM 4015 NE ARG 394 -2.193 185.475 6.468 1.00 33 .48 c
ATOM 4016 CZ ARG 394 -2.923 184.669 5.697 1.00 33.48 c
ATOM 4017 NHl ARG 394 -3.434 183.541 6.193 1.00 33 .48 c
ATOM 4018 NH2 ARG 394 -3.154 184.998 4.429 1.00 33.48 c
ATOM 4019 C ARG 394 -3.786 186.510 10.110 1.00 33 .48 c
ATOM 4020 0 ARG 394 -4.058 185.451 10.700 1.00 33 .48 c
ATOM 4021 N GLU 395 -4.561187.039 9.155 1.00 33.48 c
ATOM 4022 CA GLU 395 -5.800 186.391 8.704 1.00 33 .48 c
ATOM 4023 CB GLU 395 -5.458 185.097 7.948 1.00 33.48 c
ATOM 4024 CG GLU 395 -6.641184.409 7.263 1.00 33.48 c
ATOM 4025 CD GLU 395 -7.205 185.201 6.083 1.00 33 .48 c
ATOM 4026 OEl GLU 395 -6.399 185.572 5.182 1.00 33.48 c
ATOM 4027 OE2 GLU 395 -8.447 185.435 6.055 1.00 33.48 c
ATOM 4028 C GLU 395 -6.730 186.077 9.878 1.00 33 .48 c
ATOM 4029 0 GLU 395 -7.061 186.963 10.667 1.00 33 .48 c
ATOM 4030 N GLY 396 -7.142 184.819 10.001 1.00 33.48 c
ATOM 4031 CA GLY 396 -8.031184.446 11.089 1.00 33 .48 c
ATOM 4032 C GLY 396 -7.312 183.749 12.226 1.00 33 .48 c
ATOM 4033 0 GLY 396 -7.939 183.160 13.105 1.00 33 .48 c
ATOM 4034 N ALA 397 -5.986 183.805 12.205 1.00 33 .48 c
ATOM 4035 CA ALA 397 -5.197 183.177 13.252 1.00 33.48 c
ATOM 4036 CB ALA 397 -3.726 183.339 12.969 1.00 33 .48 c
ATOM 4037 C ALA 397 -5.532 183.781 14.609 1.00 33 .48 c
ATOM 4038 0 ALA 397 -6.703 183.811 15.006 1.00 33 .48 c
ATOM 4039 N MET 398 -4.507 184.278 15.311 1.00 33 .48 c
ATOM 4040 CA MET 398 -4.715 184.843 16.639 1.00 33.48 c
ATOM 4041 CB MET 398 -3.442 185.554 17.131 1.00 33 .48 c
ATOM 4042 CG MET 398 -2.359 184.573 17.598 1.00 33 .48 c ATOM 4043 SD MET 398 -0.897 185.285 18.469 1.00 33.48 C
ATOM 4044 CE MET 398 -0. 580 183.984 19.786 1.00 33.48 C
ATOM 4045 C MET 398 -5 .934 185.759 16.751 1.00 33.48 C
ATOM 4046 0 MET 398 -6.990 185.315 17.192 1.00 33.48 C
ATOM 4047 N SER 399 -5 . 789 187.021 16.357 1.00 33.48 C
ATOM 4048 CA SER 399 -6.884 187.997 16.440 1.00 33.48 C
ATOM 4049 CB SER 399 -8.205 187.350 16.024 1.00 33.48 C
ATOM 4050 OG SER 399 -8.049 186.732 14.756 1.00 33.48 C
ATOM 4051 C SER 399 -7.008 188.586 17.850 1.00 33.48 C
ATOM 4052 0 SER 399 -7.072 187.856 18.850 1.00 33.48 C
ATOM 4053 N GLU 400 -7 .039 189.913 17.909 1.00 33.48 C
ATOM 4054 CA GLU 400 -7. 112 190.653 19.164 1.00 33.48 c
ATOM 4055 CB GLU 400 -7 .957 191.916 18.979 1.00 33.48 c
ATOM 4056 CG GLU 400 -7.270 192.973 18.127 1.00 33.48 c
ATOM 4057 CD GLU 400 -8. 192 194.112 17.734 1.00 33.48 c
ATOM 4058 OEl GLU 400 -7 .830 194.878 16.814 1.00 33.48 c
ATOM 4059 OE2 GLU 400 -9.277 194.253 18.335 1.00 33.48 c
ATOM 4060 C GLU 400 -7. 609 189.873 20.375 1.00 33.48 c
ATOM 4061 0 GLU 400 -8. 774 189.450 20.421 1.00 33.48 c
ATOM 4062 N GLU 401 -6.693 189.674 21.329 1.00 33.48 c
ATOM 4063 CA GLU 401 -6.950 188.996 22.602 1.00 33.48 c
ATOM 4064 CB GLU 401 -8. 246 188.197 22.557 1.00 33.48 c
ATOM 4065 CG GLU 401 -8 . 817 187.870 23.940 1.00 33.48 c
ATOM 4066 CD GLU 401 -9.051 189.096 24.819 1.00 33.48 c
ATOM 4067 OEl GLU 401 -9.853 189.003 25.786 1.00 33.48 c
ATOM 4068 OE2 GLU 401 -8.428 190.146 24.556 1.00 33.48 c
ATOM 4069 C GLU 401 -5 .805 188.110 23.087 1.00 33.48 c
ATOM 4070 0 GLU 401 -5 .103 188.463 24.046 1.00 33.48 c
ATOM 4071 N ASP 402 - 5 . 599 186.961 22.459 1.00 33.48 c
ATOM 4072 CA ASP 402 -4.493 186.122 22.911 1.00 33.48 c
ATOM 4073 CB ASP 402 -4. 567 184.741 22.264 1.00 33.48 c
ATOM 4074 CG ASP 402 - 5 . 540 183.818 22.994 1.00 33.48 c
ATOM 4075 ODl ASP 402 -5 . 167 183.287 24.071 1.00 33.48 c
ATOM 4076 OD2 ASP 402 -6.684 183.641 22.503 1.00 33.48 c
ATOM 4077 C ASP 402 -3 . 167 186.815 22.605 1.00 33.48 c
ATOM 4078 0 ASP 402 -2. 207 186.727 23.387 1.00 33.48 c
ATOM 4079 N PHE 403 -3 .126 187.523 21.475 1.00 33.48 c
ATOM 4080 CA PHE 403 -1.935 188.268 21.089 1.00 33.48 c
ATOM 4081 CB PHE 403 -2 . 193 189.073 19.812 1.00 33.48 c
ATOM 4082 CG PHE 403 -0.976 189.770 19.272 1.00 33.48 c
ATOM 4083 CDl PHE 403 -0.897 191.145 19.260 1.00 33.48 c
ATOM 4084 CD2 PHE 403 0.104 189.047 18.790 1.00 33.48 c
ATOM 4085 CEl PHE 403 0.240 191.795 18.777 1.00 33.48 c
ATOM 4086 CE2 PHE 403 1. 250 189.696 18.305 1.00 33.48 c ATOM 4087 CZ PHE 403 1.312 191.068 18.301 1.00 33.48 C
ATOM 4088 c PHE 403 1.668 189.195 22.264 1.00 33.48 C
ATOM 4089 0 PHE 403 0.521 189.325 22.719 1.00 33.48 C
ATOM 4090 N ILE 404 2.740 189.810 22.774 1.00 33.48 C
ATOM 4091 CA ILE 404 2.621 190.703 23.924 1.00 33.48 C
ATOM 4092 CB ILE 404 3.989 191.149 24.481 1.00 33.48 C
ATOM 4093 CG2 ILE 404 3.785 191.887 25.794 1.00 33.48 C
ATOM 4094 CGl ILE 404 4.684 192.094 23.509 1.00 33.48 C
ATOM 4095 CDl ILE 404 3.950 193.410 23.333 1.00 33.48 C
ATOM 4096 C ILE 404 1.911 189.967 25.049 1.00 33.48 C
ATOM 4097 O ILE 404 0.865 190.409 25.546 1.00 33.48 c
ATOM 4098 N GLU 405 2.484 188.833 25.442 1.00 33.48 c
ATOM 4099 CA GLU 405 1.901 188.063 26.521 1.00 33.48 c
ATOM 4100 CB GLU 405 2.723 186.811 26.794 1.00 33.48 c
ATOM 4101 CG GLU 405 2.564 186.347 28.245 1.00 33.48 c
ATOM 4102 CD GLU 405 3.127 187.368 29.241 1.00 33.48 c
ATOM 4103 OEl GLU 405 2.669 187.376 30.412 1.00 33.48 c
ATOM 4104 OE2 GLU 405 4.034 188.153 28.854 1.00 33.48 c
ATOM 4105 C GLU 405 0.434 187.689 26.279 1.00 33.48 c
ATOM 4106 O GLU 405 0.349 187.579 27.235 1.00 33.48 c
ATOM 4107 N GLU 406 0.051 187.479 25.021 1.00 33.48 c
ATOM 4108 CA GLU 406 1.349 187.163 24.757 1.00 33.48 c
ATOM 4109 CB GLU 406 1.593 186.924 23.267 1.00 33.48 c
ATOM 4110 CG GLU 406 3.085 186.901 22.898 1.00 33.48 c
ATOM 4111 CD GLU 406 3.329 186.618 21.427 1.00 33.48 c
ATOM 4112 OEl GLU 406 4.513 186.552 21.015 1.00 33.48 c
ATOM 4113 OE2 GLU 406 2.333 186.463 20.682 1.00 33.48 c
ATOM 4114 C GLU 406 2.169 188.370 25.209 1.00 33.48 c
ATOM 4115 0 GLU 406 3.223 188.235 25.839 1.00 33.48 c
ATOM 4116 N ALA 407 1.650 189.553 24.875 1.00 33.48 c
ATOM 4117 CA ALA 407 2.291 190.821 25.211 1.00 33.48 c
ATOM 4118 CB ALA 407 1.484 191.984 24.636 1.00 33.48 c
ATOM 4119 C ALA 407 2.416 190.965 26.717 1.00 33.48 c
ATOM 4120 0 ALA 407 3.445 191.419 27.233 1.00 33.48 c
ATOM 4121 N GLU 408 1.367 190.562 27.425 1.00 33.48 c
ATOM 4122 CA GLU 408 1.370 190.672 28.870 1.00 33.48 c
ATOM 4123 CB GLU 408 0.050 190.173 29.449 1.00 33.48 c
ATOM 4124 CG GLU 408 0.222 190.792 30.799 1.00 33.48 c
ATOM 4125 CD GLU 408 0.222 192.305 30.720 1.00 33.48 c
ATOM 4126 OEl GLU 408 1.259 192.883 30.325 1.00 33.48 c
ATOM 4127 OE2 GLU 408 0.823 192.904 31.035 1.00 33.48 c
ATOM 4128 C GLU 408 2.520 189.886 29.467 1.00 33.48 c
ATOM 4129 0 GLU 408 3.306 190.420 30.251 1.00 33.48 c
ATOM 4130 N VAL 409 2.618 188.615 29.099 1.00 33.48 c ATOM 4131 CA VAL 409 3 . 705 187.790 29.599 1.00 33.,48 c
ATOM 4132 CB VAL 409 3 . 549 186.329 29.117 1.00 33. .48 c
ATOM 4133 CGl VAL 409 2.719 186.295 27.855 1.00 33, ,48 c
ATOM 4134 CG2 VAL 409 4.911185.690 28.902 1.00 33, .48 c
ATOM 4135 C VAL 409 5.064 188.384 29.180 1.00 33, .48 c
ATOM 4136 0 VAL 409 5 .945 188.586 30.033 1.00 33, .48 c
ATOM 4137 N MET 410 5.241188.685 27.892 1.00 33, .48 c
ATOM 4138 CA MET 410 6. 501189.287 27.449 1.00 33, .48 c
ATOM 4139 CB MET 410 6.399 189.788 26.008 1.00 33, .48 c
ATOM 4140 CG MET 410 6. 331 188.673 24.964 1.00 33, .48 c
ATOM 4141 SD MET 410 7 . 711 187.542 25.121 1.00 33 .48 c
ATOM 4142 CE MET 410 9.013 188.540 24.519 1.00 33, .48 c
ATOM 4143 C MET 410 6.859 190.463 28.352 1.00 33 .48 c
ATOM 4144 0 MET 410 7.957 190.529 28.901 1.00 33, .48 c
ATOM 4145 N MET 411 5 .921191.390 28.512 1.00 33 .48 c
ATOM 4146 CA MET 411 6.162 192.558 29.345 1.00 33, .48 c
ATOM 4147 CB MET 411 4.860 193.331 29.558 1.00 33 .48 c
ATOM 4148 CG MET 411 4.267 193.964 28.314 1.00 33, .48 c
ATOM 4149 SD MET 411 2 . 534 194.468 28.549 1.00 33, .48 c
ATOM 4150 CE MET 411 2. 589 195.033 30.278 1.00 33, ,48 c
ATOM 4151 C MET 411 6. 711 192.109 30.694 1.00 33, .48 c
ATOM 4152 0 MET 411 7.710 192.635 31.189 1.00 33, .48 c
ATOM 4153 N LYS 412 6.055 191.112 31.276 1.00 33, .48 c
ATOM 4154 CA LYS 412 6.442 190.593 32.585 1.00 33, .48 c
ATOM 4155 CB LYS 412 5 .484 189.472 33.015 1.00 33, .48 c
ATOM 4156 CG LYS 412 4.063 189.937 33.312 1.00 33 .48 c
ATOM 4157 CD LYS 412 3 .269 188.874 34.085 1.00 33, .48 c
ATOM 4158 CE LYS 412 1.863 189.382 34.414 1.00 33 .48 c
ATOM 4159 NZ LYS 412 1. 874 190.691 35.157 1.00 33 .48 c
ATOM 4160 C LYS 412 7.877 190.088 32.741 1.00 33 .48 c
ATOM 4161 0 LYS 412 8.432 190.143 33.839 1.00 33 .48 c
ATOM 4162 N LEU 413 8.486 189.606 31.663 1.00 33 .48 c
ATOM 4163 CA LEU 413 9.839 189.070 31.798 1.00 33 .48 c
ATOM 4164 CB LEU 413 9.802 187.543 31.649 1.00 33 .48 c
ATOM 4165 CG LEU 413 9. 500 187.071 30.231 1.00 33 .48 c
ATOM 4166 CDl LEU 413 10.813 186.689 29.572 1.00 33 .48 c
ATOM 4167 CD2 LEU 413 8. 532 185.899 30.255 1.00 33 .48 c
ATOM 4168 C LEU 413 10.871 189.640 30.845 1.00 33 .48 c
ATOM 4169 0 LEU 413 10. 537 190.174 29.796 1.00 33, .48 c
ATOM 4170 N SER 414 12.134 189.515 31.228 1.00 33 .48 c
ATOM 4171 CA SER 414 13.238 189.992 30.413 1.00 33, .48 c
ATOM 4172 CB SER 414 13 .403 191.507 30.552 1.00 33, .48 c
ATOM 4173 OG SER 414 14.012 191.837 31.783 1.00 33 .48 c
ATOM 4174 C SER 414 14.479 189.278 30.931 1.00 33, .48 c ATOM 4175 O SER 414 14.628 189.085 32.147 1.00 33.48 C
ATOM 4176 N HIS 415 15.364 188.896 30.008 1.00 33.48 C
ATOM 4177 CA HIS 415 16.589 188.163 30.334 1.00 33.48 C
ATOM 4178 CB HIS 415 16.203 186.754 30.813 1.00 33.48 C
ATOM 4179 CG HIS 415 17.362 185.828 31.010 1.00 33.48 C
ATOM 4180 CD2 HIS 415 17.728 185.076 32.074 1.00 33.48 C
ATOM 4181 NDl HIS 415 18.302 185.590 30.029 1.00 33.48 C
ATOM 4182 CEl HIS 415 19.200 184.734 30.482 1.00 33.48 C
ATOM 4183 NE2 HIS 415 18.875 184.408 31.721 1.00 33.48 C
ATOM 4184 C HIS 415 17.421 188.086 29.053 1.00 33.48 C
ATOM 4185 O HIS 415 16.896 187.771 27.994 1.00 33.48 C
ATOM 4186 N PRO 416 18.729 188.348 29.137 1.00 33.48 C
ATOM 4187 CD PRO 416 19.495 188.447 30.384 1.00 33.48 C
ATOM 4188 CA PRO 416 19.640 188.319 27.990 1.00 33.48 C
ATOM 4189 CB PRO 416 21.008 188.169 28.642 1.00 33.48 c
ATOM 4190 CG PRO 416 20.848 188.913 29.883 1.00 33.48 c
ATOM 4191 C PRO 416 19.387 187.239 26.946 1.00 33.48 c
ATOM 4192 0 PRO 416 19.690 187.425 25.771 1.00 33.48 c
ATOM 4193 N LYS 417 18.835 186.110 27.356 1.00 33.48 c
ATOM 4194 CA LYS 417 18.584 185.065 26.390 1.00 33.48 c
ATOM 4195 CB LYS 417 19.138 183.751 26.918 1.00 33.48 c
ATOM 4196 CG LYS 417 20.637 183.833 27.226 1.00 33.48 c
ATOM 4197 CD LYS 417 21.405 184.585 26.131 1.00 33.48 c
ATOM 4198 CE LYS 417 22.897 184.466 26.330 1.00 33.48 c
ATOM 4199 NZ LYS 417 23.256 184.672 27.758 1.00 33.48 c
ATOM 4200 C LYS 417 17.119 184.943 25.985 1.00 33.48 c
ATOM 4201 0 LYS 417 16.700 183.958 25.375 1.00 33.48 c
ATOM 4202 N LEU 418 16.342 185.963 26.328 1.00 33.48 c
ATOM 4203 CA LEU 418 14.942 186.013 25.951 1.00 33.48 c
ATOM 4204 CB LEU 418 14.060 186.300 27.162 1.00 33.48 c
ATOM 4205 CG LEU 418 12.655 185.675 27.138 1.00 33.48 c
ATOM 4206 CDl LEU 418 11.964 185.944 25.806 1.00 33.48 c
ATOM 4207 CD2 LEU 418 12.773 184.169 27.371 1.00 33.48 c
ATOM 4208 C LEU 418 14.905 187.190 24.999 1.00 33.48 c
ATOM 4209 0 LEU 418 15.497 188.219 25.290 1.00 33.48 c
ATOM 4210 N VAL 419 14.253 187.058 23.853 1.00 33.48 c
ATOM 4211 CA VAL 419 14.215 188.184 22.935 1.00 33.48 c
ATOM 4212 CB VAL 419 13.477 187.838 21.647 1.00 33.48 c
ATOM 4213 CGl VAL 419 11.984 187.864 21.883 1.00 33.48 c
ATOM 4214 CG2 VAL 419 13.885 188.803 20.555 1.00 33.48 c
ATOM 4215 C VAL 419 13.503 189.322 23.664 1.00 33.48 c
ATOM 4216 0 VAL 419 12.523 189.100 24.375 1.00 33.48 c
ATOM 4217 N GLN 420 13.995 190.541 23.490 1.00 33.48 c
ATOM 4218 CA GLN 420 13.427 191.679 24.197 1.00 33.48 c ATOM 4219 CB GLN 420 14.522 192.664 24.546 1.00 33.48 C
ATOM 4220 CG GLN 420 14.092 193.736 25.482 1.00 33.48 C
ATOM 4221 CD GLN 420 15.234 194.667 25.815 1.00 33.48 C
ATOM 4222 OEl GLN 420 15.038 195.725 26.429 1.00 33.48 C
ATOM 4223 NE2 GLN 420 16.446 194.281 25.412 1.00 33.48 C
ATOM 4224 C GLN 420 12.322 192.426 23.514 1.00 33.48 C
ATOM 4225 O GLN 420 12.400 192.726 22.333 1.00 33.48 C
ATOM 4226 N LEU 421 11.299 192.747 24.297 1.00 33.48 C
ATOM 4227 CA LEU 421 10.133 193.480 23.820 1.00 33.48 C
ATOM 4228 CB LEU 421 8.882 193.038 24.575 1.00 33.48 C
ATOM 4229 CG LEU 421 7.621 193.857 24.322 1.00 33.48 C
ATOM 4230 CDl LEU 421 7.078 193.559 22.944 1.00 33.48 C
ATOM 4231 CD2 LEU 421 6.594 193.527 25.355 1.00 33.48 C
ATOM 4232 C LEU 421 10.340 194.964 24.046 1.00 33.48 C
ATOM 4233 0 LEU 421 10.585 195.403 25.168 1.00 33.48 C
ATOM 4234 N TYR 422 10.255 195.732 22.972 1.00 33.48 C
ATOM 4235 CA TYR 422 10.414 197.165 23.077 1.00 33.48 C
ATOM 4236 CB TYR 422 10.848 197.741 21.739 1.00 33.48 C
ATOM 4237 CG TYR 422 12.302 197.527 21.438 1.00 33.48 c
ATOM 4238 CDl TYR 422 12.782 197.633 20.142 1.00 33.48 c
ATOM 4239 CEl TYR 422 14.125 197.488 19.867 1.00 33.48 c
ATOM 4240 CD2 TYR 422 13.205 197.269 22.455 1.00 33.48 c
ATOM 4241 CE2 TYR 422 14.544 197.126 22.195 1.00 33.48 c
ATOM 4242 CZ TYR 422 15.002 197.234 20.899 1.00 33.48 c
ATOM 4243 OH TYR 422 16.338 197.060 20.640 1.00 33.48 c
ATOM 4244 C TYR 422 9.106197.794 23.517 1.00 33.48 c
ATOM 4245 0 TYR 422 9.098 198.634 24.404 1.00 33.48 c
ATOM 4246 N GLY 423 8.001 197.387 22.902 1.00 33.48 c
ATOM 4247 CA GLY 423 6.720 197.941 23.288 1.00 33.48 c
ATOM 4248 C GLY 423 5.495 197.465 22.528 1.00 33.48 c
ATOM 4249 0 GLY 423 5.587 197.014 21.389 1.00 33.48 c
ATOM 4250 N VAL 424 4.338 197.594 23.177 00 33.48 c
ATOM 4251 CA VAL 424 3.050 197.200 22.619 00 33.48 c
ATOM 4252 CB VAL 424 2.005 197.053 23.710 00 33.48 c
ATOM 4253 CGl VAL 424 2.442 196.002 24.696 00 33.48 c
ATOM 4254 CG2 VAL 424 1.824 198.389 24.412 00 33.48 c
ATOM 4255 C VAL 424 2.540 198.230 21.633 1.00 33.48 c
ATOM 4256 0 VAL 424 3.205 199.218 21.369 1.00 33.48 c
ATOM 4257 N CYS 425 1.336 198.008 21.120 1.00 33.48 c
ATOM 4258 CA CYS 425 0.733 198.884 20.120 1.00 33.48 c
ATOM 4259 CB CYS 425 1.709 198.885 18.923 1.00 33.48 c
ATOM 4260 SG CYS 425 1.264 198.854 17.155 1.00 33.48 c
ATOM 4261 C CYS 425 -0.657 198.254 19.889 1.00 33.48 c
ATOM 4262 0 CYS 425 -0.958 197.684 18.840 1.00 33.48 c ATOM 4263 N LEU 426 1.496 198.388 20.927 1.00 33.48 C
ATOM 4264 CA LEU 426 2.833 197.787 20.975 1.00 33.48 C
ATOM 4265 CB LEU 426 2.963 197.036 22.309 1.00 33.48 C
ATOM 4266 CG LEU 426 1.674 196.316 22.755 1.00 33.48 c
ATOM 4267 CDl LEU 426 1.839 195.734 24.143 1.00 33.48 c
ATOM 4268 CD2 LEU 426 1.312 195.228 21.766 1.00 33.48 c
ATOM 4269 C LEU 426 4.122 198.609 20.729 1.00 33.48 c
ATOM 4270 O LEU 426 5.214 198.116 21.006 1.00 33.48 c
ATOM 4271 N GLU 427 4.018 199.837 20.217 1.00 33.48 c
ATOM 4272 CA GLU 427 5.210 200.651 19.929 1.00 33.48 c
ATOM 4273 CB GLU 427 4.832 202.124 19.737 1.00 33.48 c
ATOM 4274 CG GLU 427 5.106 203.052 20.920 1.00 33.48 c
ATOM 4275 CD GLU 427 6.594 203.312 21.158 1.00 33.48 c
ATOM 4276 OEl GLU 427 7.220 202.552 21.934 1.00 33.48 c
ATOM 4277 OE2 GLU 427 7.144 204.275 20.569 1.00 33.48 c
ATOM 4278 C GLU 427 5.892 200.152 18.656 1.00 33.48 c
ATOM 4279 0 GLU 427 5.389 200.336 17.541 1.00 33.48 c
ATOM 4280 N ILE 431 3.374 195.471 15.818 1.00 33.48 c
ATOM 4281 CA ILE 431 2.528 195.588 16.995 1.00 33.48 c
ATOM 4282 CB ILE 431 3.164 194.845 18.189 1.00 33.48 c
ATOM 4283 CG2 ILE 431 4.560 195.394 18.435 1.00 33.48 c
ATOM 4284 CGl ILE 431 3.285 193.352 17.894 1.00 33.48 c
ATOM 4285 CDl ILE 431 3.951 192.586 18.999 1.00 33.48 c
ATOM 4286 C ILE 431 1.128 195.049 16.686 1.00 33.48 c
ATOM 4287 0 ILE 431 0.940 194.273 15.748 1.00 33.48 c
ATOM 4288 N CYS 432 0.140 195.436 17.480 1.00 33.48 c
ATOM 4289 CA CYS 432 1.197 195.002 17.164 1.00 33.48 c
ATOM 4290 CB CYS 432 1.687 195.856 16.013 1.00 33.48 c
ATOM 4291 SG CYS 432 2.528 197.445 16.330 1.00 33.48 c
ATOM 4292 C CYS 432 2.198 195.016 18.290 1.00 33.48 c
ATOM 4293 0 CYS 432 2.133 195.859 19.177 1.00 33.48 c
ATOM 4294 N LEU 433 3.127 194.063 18.241 1.00 33.48 c
ATOM 4295 CA LEU 433 4.182 193.929 19.239 1.00 33.48 c
ATOM 4296 CB LEU 433 4.234 192.502 19.743 1.00 33.48 c
ATOM 4297 CG LEU 433 3.560 192.148 21.061 1.00 33.48 c
ATOM 4298 CDl LEU 433 2.174 192.789 21.170 1.00 33.48 c
ATOM 4299 CD2 LEU 433 3.500 190.625 21.140 1.00 33.48 c
ATOM 4300 C LEU 433 5.519 194.290 18.620 1.00 33.48 c
ATOM 4301 0 LEU 433 5.781 193.961 17.475 1.00 33.48 c
ATOM 4302 N VAL 434 6.368 194.974 19.371 1.00 33.48 c
ATOM 4303 CA VAL 434 7.654 195.356 18.829 1.00 33.48 c
ATOM 4304 CB VAL 434 7.768 196.874 18.711 1.00 33.48 c
ATOM 4305 CGl VAL 434 9.096 197.251 18.106 1.00 33.48 c
ATOM 4306 CG2 VAL 434 6.648 197.395 17.828 1.00 33.48 c ATOM 4307 c VAL 434 8.8191194.791 19.630 1.00 33.,48 c
ATOM 4308 0 VAL 434 8.956 195.020 20.839 1.00 33. ,48 c
ATOM 4309 N PHE 435 9.654 194.034 18.921 1.00 33. ,48 c
ATOM 4310 CA PHE 435 10.802 193.371 19.501 1.00 33. ,48 c
ATOM 4311 CB PHE 435 10.698 191.860 19.285 1.00 33. .48 c
ATOM 4312 CG PHE 435 9.510 191.231 19.942 1.00 33. .48 c
ATOM 4313 CDl PHE 435 9.555 190.858 21.270 1.00 33. .48 c
ATOM 4314 CD2 PHE 435 8.339 191.048 19.240 1.00 33. .48 c
ATOM 4315 CEl PHE 435 8.460 190.320 21.878 1.00 33. .48 c
ATOM 4316 CE2 PHE 435 7.239 190.510 19.847 1.00 33, .48 c
ATOM 4317 CZ PHE 435 7.297 190.144 21.167 1.00 33, .48 c
ATOM 4318 C PHE 435 12.047 193.849 18.830 1.00 33, .48 c
ATOM 4319 O PHE 435 11.996 194.524 17.806 1.00 33, .48 c
ATOM 4320 N GLU 436 13.171 193.467 19.411 1.00 33, .48 c
ATOM 4321 CA GLU 436 14.468 193.816 18.880 1.00 33, .48 c
ATOM 4322 CB GLU 436 15.535 193.530 19.928 1.00 33, .48 c
ATOM 4323 CG GLU 436 15.703 192.075 20.215 1.00 33, .48 c
ATOM 4324 CD GLU 436 16.593 191.812 21.396 1.00 33, .48 c
ATOM 4325 OEl GLU 436 17.741 192.301 21.413 1.00 33, .48 c
ATOM 4326 OE2 GLU 436 16.144 191.099 22.316 1.00 33, .48 c
ATOM 4327 C GLU 436 14.694 192.954 17.646 1.00 33, .48 c
ATOM 4328 O GLU 436 14.274 191.803 17.604 1.00 33, .48 c
ATOM 4329 N PHE 437 15.344 193.508 16.636 1.00 33 .48 c
ATOM 4330 CA PHE 437 15.602 192.768 15.417 1.00 33, .48 c
ATOM 4331 CB PHE 437 15.951 193.727 14.291 1.00 33, .48 c
ATOM 4332 CG PHE 437 16.324 193.055 13.000 1.00 33 .48 c
ATOM 4333 CDl PHE 437 17.594 193.200 12.473 1.00 33 .48 c
ATOM 4334 CD2 PHE 437 15.382 192.330 12.276 1.00 33 .48 c
ATOM 4335 CEl PHE 437 17.915 192.642 11.248 1.00 33 .48 c
ATOM 4336 CE2 PHE 437 15.700 191.766 11.042 1.00 33 .48 c
ATOM 4337 CZ PHE 437 16.963 191.925 10.531 1.00 33 .48 c
ATOM 4338 C PHE 437 16.731 191.777 15.597 1.00 33 .48 c
ATOM 4339 O PHE 437 17.784 192.097 16.149 1.00 33 .48 c
ATOM 4340 N MET 438 16.497 190.558 15.136 1.00 33 .48 c
ATOM 4341 CA MET 438 17.499 189.524 15.209 1.00 33 .48 c
ATOM 4342 CB MET 438 16.888 188.205 15.667 1.00 33 .48 c
ATOM 4343 CG MET 438 16.400 188.240 17.098 1.00 33 .48 c
ATOM 4344 SD MET 438 17.660 188.799 18.265 1.00 33 .48 c
ATOM 4345 CE MET 438 18.421 187.292 18.755 1.00 33 .48 c
ATOM 4346 C MET 438 18.092 189.400 13.823 1.00 33 .48 c
ATOM 4347 O MET 438 17.504 188.834 12.910 1.00 33 .48 c
ATOM 4348 N GLU 439 19.273 189.973 13.692 1.00 33 .48 c
ATOM 4349 CA GLU 439 20.031 189.983 12.465 1.00 33 .48 c
ATOM 4350 CB GLU 439 21.469 190.347 12.800 1.00 33 .48 c ATOM 4351 CG GLU 439 22.313 190.729 11.608 1.00 33.48 c
ATOM 4352 CD GLU 439 23.772 190.925 11.984 1.00 33 .48 c
ATOM 4353 OEl GLU 439 24.045 191.179 13.187 1.00 33 .48 c
ATOM 4354 OE2 GLU 439 24.639 190.832 11.075 1.00 33 .48 c
ATOM 4355 C GLU 439 20.035 188.691 11.659 1.00 33, .48 c
ATOM 4356 0 GLU 439 19.930 188.728 10.437 1.00 33, .48 c
ATOM 4357 N HIS 440 20.149 187.550 12.334 1.00 33, .48 c
ATOM 4358 CA HIS 440 20.244 186.273 11.630 1.00 33 .48 c
ATOM 4359 CB HIS 440 21.467 185.529 12.150 1.00 33 .48 c
ATOM 4360 CG HIS 440 22.743 186.283 11.949 1.00 33 .48 c
ATOM 4361 CD2 HIS 440 23.590 186.853 12.838 1.00 33, .48 c
ATOM 4362 NDl HIS 440 23.237 186.585 10.700 1.00 33, .48 c
ATOM 4363 CEl HIS 440 24.332 187.311 10.827 1.00 33, .48 c
ATOM 4364 NE2 HIS 440 24.567 187.488 12.115 1.00 33, .48 c
ATOM 4365 C HIS 440 19.082 185.293 11.519 1.00 33, .48 c
ATOM 4366 0 HIS 440 19.270 184.198 10.999 1.00 33 .48 c
ATOM 4367 N GLY 441 17.897 185.652 11.995 1.00 33 .48 c
ATOM 4368 CA GLY 441 16.766 184.753 11.852 1.00 33 .48 c
ATOM 4369 C GLY 441 16.601 183.591 12.810 1.00 33 .48 c
ATOM 4370 0 GLY 441 16.971 183.645 13.978 1.00 33, .48 c
ATOM 4371 N CYS 442 16.018 182.519 12.300 1.00 33, .48 c
ATOM 4372 CA CYS 442 15.765 181.329 13.105 1.00 33, .48 c
ATOM 4373 CB CYS 442 14.586 180.556 12.522 1.00 33, .48 c
ATOM 4374 SG CYS 442 13.109 181.543 12.268 1.00 33, .48 c
ATOM 4375 C CYS 442 16.957 180.391 13.213 1.00 33, .48 c
ATOM 4376 0 CYS 442 17.646 180.144 12.231 1.00 33, .48 c
ATOM 4377 N LEU 443 17.172 179.855 14.410 1.00 33, .48 c
ATOM 4378 CA LEU 443 18.264 178.925 14.653 1.00 33, .48 c
ATOM 4379 CB LEU 443 18.130 178.294 16.051 1.00 33, .48 c
ATOM 4380 CG LEU 443 19.408 178.073 16.891 1.00 33, .48 c
ATOM 4381 CDl LEU 443 19.116 177.053 17.985 1.00 33, .48 c
ATOM 4382 CD2 LEU 443 20.557 177.585 16.029 1.00 33, .48 c
ATOM 4383 C LEU 443 18.266 177.815 13.594 1.00 33, .48 c
ATOM 4384 0 LEU 443 19.293 177.563 12.963 1.00 33, .48 c
ATOM 4385 N SER 444 17.120 177.163 13.399 1.00 33, .48 c
ATOM 4386 CA SER 444 17.013 176.089 12.421 1.00 33, .48 c
ATOM 4387 CB SER 444 15.564 175.650 12.242 1.00 33, .48 c
ATOM 4388 OG SER 444 14.691 176.422 13.032 1.00 33, .48 c
ATOM 4389 C SER 444 17.576 176.460 11.060 1.00 33, .48 c
ATOM 4390 0 SER 444 18.440 175.768 10.525 1.00 33, .48 c
ATOM 4391 N ASP 445 17.085 177.547 10.490 1.00 33, .48 c
ATOM 4392 CA ASP 445 17.556 177.973 9.191 1.00 33, .48 c
ATOM 4393 CB ASP 445 16.697 179.118 8.687 1.00 33. ,48 c
ATOM 4394 CG ASP 445 15.240 178.739 8.588 1.00 33. ,48 c ATOM 4395 ODl ASP 445 14.970 177.659 8.028 1.00 33.48 C
ATOM 4396 OD2 ASP 445 14.372 179.507 9.062 1.00 33.48 C
ATOM 4397 C ASP 445 19.006 178.400 9.215 1.00 33.48 C
ATOM 4398 O ASP 445 19.736 178.204 8.255 1.00 33.48 C
ATOM 4399 N TYR 446 19.433 178.988 10.318 1.00 33.48 C
ATOM 4400 CA TYR 446 20.810 179.440 10.418 1.00 33.48 C
ATOM 4401 CB TYR 446 21.018 180.245 11.703 1.00 33.48 C
ATOM 4402 CG TYR 446 22.391180.865 11.833 1.00 33.48 C
ATOM 4403 CDl TYR 446 22.862 181.751 10.876 1.00 33.48 C
ATOM 4404 CEl TYR 446 24.096182.356 11.005 1.00 33.48 C
ATOM 4405 CD2 TYR 446 23.201180.591 12.930 1.00 33.48 C
ATOM 4406 CE2 TYR 446 24.439 181.190 13.067 1.00 33.48 C
ATOM 4407 CZ TYR 446 24.876 182.076 12.101 1.00 33.48 C
ATOM 4408 OH TYR 446 26.078 182.718 12.247 1.00 33.48 C
ATOM 4409 C TYR 446 21.761178.259 10.405 1.00 33.48 C
ATOM 4410 O TYR 446 22.827 178.315 9.791 1.00 33.48 C
ATOM 4411 N LEU 447 21.378 177.191 11.095 1.00 33.48 C
ATOM 4412 CA LEU 447 22.208 176.005 11.158 1.00 33.48 C
ATOM 4413 CB LEU 447 21.677 175.058 12.225 1.00 33.48 C
ATOM 4414 CG LEU 447 21.812 175.542 13.670 1.00 33.48 C
ATOM 4415 CDl LEU 447 21.041 174.622 14.607 1.00 33.48 C
ATOM 4416 CD2 LEU 447 23.283 175.607 14.048 1.00 33.48 C
ATOM 4417 C LEU 447 22.230175.307 9.808 1.00 33.48 c
ATOM 4418 O LEU 447 23.211 174.660 9.442 1.00 33.48 c
ATOM 4419 N ARG, 448 21.158 175.459 9.047 1.00 33.48 c
ATOM 4420 CA ARG 448 21.084174.807 7.755 1.00 33.48 c
ATOM 4421 CB ARG 448 19.634 174.570 7.398 1.00 33.48 c
ATOM 4422 CG ARG 448 18.973 173.678 8.383 1.00 33.48 c
ATOM 4423 CD ARG 448 17.504 173.686 8.210 1.00 33.48 c
ATOM 4424 NE ARG 448 16.918 172.827 9.215 1.00 33.48 c
ATOM 4425 CZ ARG 448 15.623 172.753 9.472 1.00 33.48 c
ATOM 4426 NHl ARG 448 14.772 173.504 8.783 1.00 33.48 c
ATOM 4427 NH2 ARG 448 15.188 171.920 10.417 1.00 33.48 c
ATOM 4428 C ARG 448 21.776 175.549 6.639 1.00 33.48 c
ATOM 4429 0 ARG 448 22.502 174.951 5.852 1.00 33.48 c
ATOM 4430 N THR 449 21.554 176.851 6.558 1.00 33.48 c
ATOM 4431 CA THR 449 22.196 177.631 5.511 1.00 33.48 c ATOM 4432 CB THR 449 21.608 179.073 5.445 1.00 33.48 c ATOM 4433 OGl THR 449 20.178 179.003 5.528 1.00 33.48 c ATOM 4434 CG2 THR 449 21.963 179.746 4.115 1.00 33.48 c ATOM 4435 C THR 449 23.701 177.675 5.794 1.00 33.48 c ATOM 4436 0 THR 449 24.516177.805 4.882 1.00 33.48 c ATOM 4437 N GLN 450 24.066 177.556 7.063 1.00 33.48 c ATOM 4438 CA GLN 450 25.466 177.579 7.437 1.00 33.48 c ATOM 4439 CB GLN 450 25.703 178.525 8.623 1.00 33.48 C
ATOM 4440 CG GLN 450 25.525 180.015 8.313 1.00 33.48 C
ATOM 4441 CD GLN 450 26.298 180.464 7.082 1.00 33.48 C
ATOM 4442 OEl GLN 450 27.509 180.280 6.995 1.00 33.48 C
ATOM 4443 NE2 GLN 450 25.593 181.061 6.120 1.00 33.48 C
ATOM 4444 C GLN 450 25.932 176.175 7.785 1.00 33.48 C
ATOM 4445 O GLN 450 27.023 175.986 8.337 1.00 33.48 C
ATOM 4446 N ARG 451 25.109 175.181 7.470 1.00 33.48 C
ATOM 4447 CA ARG 451 25.505 173.806 7.755 1.00 33.48 C
ATOM 4448 CB ARG 451 24.494 172.813 7.184 1.00 33.48 C
ATOM 4449 CG ARG 451 24.839 171.349 7.445 1.00 33.48 C
ATOM 4450 CD ARG 451 23.757 170.415 6.882 1.00 33.48 C
ATOM 4451 NE ARG 451 22.496 170.498 7.621 1.00 33.48 C
ATOM 4452 CZ ARG 451 21.318 170.106 7.138 1.00 33.48 C
ATOM 4453 NHl ARG 451 21.226169.606 5.920 1.00 33.48 C
ATOM 4454 NH2 ARG 451 20.223 170.219 7.868 1.00 33.48 C
ATOM 4455 C ARG 451 26.874 173.578 7.121 1.00 33.48 C
ATOM 4456 O ARG 451 27.128 173.981 5.978 1.00 33.48 c
ATOM 4457 N GLY 452 27.767 172.961 7.878 1.00 33.48 c
ATOM 4458 CA GLY 452 29.095 172.712 7.355 1.00 33.48 c
ATOM 4459 C GLY 452 30.196 173.589 7.929 1.00 33.48 c
ATOM 4460 O GLY 452 31.339173.144 8.043 1.00 33.48 c
ATOM 4461 N LEU 453 29.873 174.819 8.315 1.00 33.48 c
ATOM 4462 CA LEU 453 30.905 175.714 8.837 1.00 33.48 c
ATOM 4463 CB LEU 453 30.848 177.043 8.086 1.00 33.48 c
ATOM 4464 CG LEU 453 30.332 176.961 6.643 1.00 33.48 c
ATOM 4465 CDl LEU 453 30.220178.352 6.062 1.00 33.48 c
ATOM 4466 CD2 LEU 453 31.259 176.111 5.804 1.00 33.48 c
ATOM 4467 C LEU 453 30.800175.985 10.333 1.00 33.48 c
ATOM 4468 O LEU 453 31.069177.090 10.774 1.00 33.48 c
ATOM 4469 N PHE 454 30.415 174.983 11.113 1.00 33.48 c
ATOM 4470 CA PHE 454 30.275 175.166 12.552 1.00 33.48 c
ATOM 4471 CB PHE 454 28.878 174.757 13.009 1.00 33.48 c
ATOM 4472 CG PHE 454 27.823 175.753 12.700 1.00 33.48 c
ATOM 4473 CDl PHE 454 27.932 177.064 13.158 1.00 33.48 c
ATOM 4474 CD2 PHE 454 26.698 175.382 11.979 1.00 33.48 c
ATOM 4475 CEl PHE 454 26.929 178.001 12.903 1.00 33.48 c
ATOM 4476 CE2 PHE 454 25.687 176.303 11.713 1.00 33.48 c
ATOM 4477 CZ PHE 454 25.800 177.618 12.176 1.00 33.48 c
ATOM 4478 C PHE 454 31.274174.365 13.373 1.00 33.48 c
ATOM 4479 O PHE 454 31.520 173.189 13.096 1.00 33.48 c
ATOM 4480 N ALA 455 31.841175.003 14.391 1.00 33.48 c
ATOM 4481 CA ALA 455 32.753 174.318 15.287 1.00 33.48 c
ATOM 4482 CB ALA 455 33.712 175.292 15.908 1.00 33.48 c ATOM 4483 C ALA 455 31.843 173.711 16.356 1.,00 33.48 c
ATOM 4484 O ALA 455 30.818 174.288 16.714 1. ,00 33.48 c
ATOM 4485 N ALA 456 32.200 172.535 16.851 1. .00 33.48 c
ATOM 4486 CA ALA 456 31.382 171.875 17.857 1. .00 33.48 c
ATOM 4487 CB ALA 456 32.009 170.541 18.236 1. .00 33.48 c
ATOM 4488 C ALA 456 31.232 172.755 19.088 1. .00 33.48 c
ATOM 4489 O ALA 456 30.127 172.937 19.599 1. .00 33.48 c
ATOM 4490 N GLU 457 32.353 173.297 19.556 1. .00 33.48 c
ATOM 4491 CA GLU 457 32.352 174.157 20.731 1. .00 33.48 c
ATOM 4492 CB GLU 457 33.726 174.845 20.870 1. .00 33.48 c
ATOM 4493 CG GLU 457 34.808 173.994 21.590 1. .00 33.48 c
ATOM 4494 CD GLU 457 35.733 173.171 20.647 1. .00 33.48 c
ATOM 4495 OEl GLU 457 36.561 173.799 19.927 1. .00 33.48 c
ATOM 4496 OE2 GLU 457 35.643 171.906 20.633 1. .00 33.48 c
ATOM 4497 C GLU 457 31.215 175.192 20.628 1. .00 33.48 c
ATOM 4498 O GLU 457 30.493 175.469 21.600 1. .00 33.48 c
ATOM 4499 N THR 458 31.061 175.732 19.424 1. .00 33.48 c
ATOM 4500 CA THR 458 30.050176.727 19.102 1. .00 33.48 c
ATOM 4501 CB THR 458 30.241177.214 17.662 1. .00 33.48 c
ATOM 4502 OGl THR 458 31.561177.748 17.517 1. .00 33.48 c
ATOM 4503 CG2 THR 458 29.236 178.276 17.324 1. .00 33.48 c
ATOM 4504 C THR 458 28.621176.200 19.247 1. .00 33.48 c
ATOM 4505 O THR 458 27.792 176.810 19.929 1. .00 33.48 c
ATOM 4506 N LEU 459 28.331 175.075 18.599 1. .00 33.48 c
ATOM 4507 CA LEU 459 26.996 174.494 18.658 1. .00 33.48 c
ATOM 4508 CB LEU 459 26.944 173.201 17.856 1. .00 33.48 c
ATOM 4509 CG LEU 459 27.448 173.262 16.412 1. .00 33.48 c
ATOM 4510 CDl LEU 459 27.448 171.844 15.820 1. .00 33.48 c
ATOM 4511 CD2 LEU 459 26.577 174.192 15.590 1, .00 33.48 c
ATOM 4512 C LEU 459 26.609 174.221 20.100 1, .00 33.48 c
ATOM 4513 O LEU 459 25.427 174.148 20.431 1. .00 33.48 c
ATOM 4514 N LEU 460 27.611 174.055 20.957 1, .00 33.48 c
ATOM 4515 CA LEU 460 27.349 173.813 22.370 1, .00 33.48 c
ATOM 4516 CB LEU 460 28.610 173.317 23.091 1, .00 33.48 c
ATOM 4517 CG LEU 460 28.515 173.274 24.622 1, .00 33.48 c
ATOM 4518 CDl LEU 460 27.625 172.124 25.050 1, .00 33.48 c
ATOM 4519 CD2 LEU 460 29.894 173.136 25.227 1, .00 33.48 c
ATOM 4520 C LEU 460 26.929 175.153 22.944 1, .00 33.48 c
ATOM 4521 0 LEU 460 26.005 175.235 23.754 1, .00 33.48 c
ATOM 4522 N GLY 461 27.627 176.199 22.507 1, .00 33.48 c
ATOM 4523 CA GLY 461 27.332 177.544 22.957 1, .00 33.48 c
ATOM 4524 C GLY 461 25.885 177.922 22.705 1 .00 33.48 c
ATOM 4525 0 GLY 461 25.205 178.428 23.595 1 .00 33.48 c
ATOM 4526 N MET 462 25.407 177.680 21.494 1, .00 33.48 c ATOM 4527 CA MET 462 24.031178.001 21.179 1.00 33.48 C
ATOM 4528 CB MET 462 23.680177.488 19.791 1.00 33.48 C
ATOM 4529 CG MET 462 24.828 177.567 18.817 1.00 33.48 C
ATOM 4530 SD MET 462 24.282 177.432 17.133 1.00 33.48 C
ATOM 4531 CE MET 462 24.969 178.948 16.419 1.00 33.48 C
ATOM 4532 C MET 462 23.156177.320 22.212 1.00 33.48 C
ATOM 4533 0 MET 462 22.198 177.902 22.708 1.00 33.48 C
ATOM 4534 N CYS 463 23.506176.079 22.535 1.00 33.48 C
ATOM 4535 CA CYS 463 22.778 175.271 23.515 1.00 33.48 C
ATOM 4536 CB CYS 463 23.355 173.841 23.558 1.00 33.48 C
ATOM 4537 SG CYS 463 22.927 172.743 22.174 1.00 33.48 C
ATOM 4538 C CYS 463 22.840175.870 24.919 1.00 33.48 C
ATOM 4539 0 CYS 463 21.872 175.798 25.675 1.00 33.48 C
ATOM 4540 N LEU 464 23.994176.444 25.258 1.00 33.48 C
ATOM 4541 CA LEU 464 24.209177.051 26.565 1.00 33 .48 C
ATOM 4542 CB LEU 464 25.663 177.469 26.723 1.00 33.48 C
ATOM 4543 CG LEU 464 26.377 176.806 27.901 1.00 33.48 C
ATOM 4544 CDl LEU 464 27.769 177.390 28.027 1.00 33.48 C
ATOM 4545 CD2 LEU 464 25.587 177.021 29.186 1.00 33.48 c
ATOM 4546 C LEU 464 23.319 178.259 26.760 1.00 33.48 c
ATOM 4547 0 LEU 464 22.731178.451 27.820 1.00 33.48 c
ATOM 4548 N ASP 465 23.235 179.083 25.727 1.00 33.48 c
ATOM 4549 CA ASP 465 22.396180.261 25.764 1.00 33.48 c
ATOM 4550 CB ASP 465 22.556181.046 24.472 1.00 33.48 c
ATOM 4551 CG ASP 465 23.899 181.708 24.368 1.00 33.48 c
ATOM 4552 ODl ASP 465 24.220182.226 23.276 1.00 33.48 c
ATOM 4553 OD2 ASP 465 24.633 181.720 25.381 1.00 33.48 c
ATOM 4554 C ASP 465 20.941179.855 25.946 1.00 33.48 c
ATOM 4555 0 ASP 465 20.283 180.291 26.885 1.00 33.48 c
ATOM 4556 N VAL 466 20.436179.014 25.056 1.00 33.48 c
ATOM 4557 CA VAL 466 19.054178.601 25.174 1.00 33.48 c
ATOM 4558 CB VAL 466 18.692 177.509 24.156 1.00 33.48 c
ATOM 4559 CGl VAL 466 17.200177.232 24.214 1.00 33.48 c
ATOM 4560 CG2 VAL 466 19.101177.929 22.766 1.00 33.48 c
ATOM 4561 C VAL 466 18.766 178.077 26.578 1.00 33.48 c
ATOM 4562 0 VAL 466 17.638 178.159 27.061 1.00 33 .48 c
ATOM 4563 N CYS 467 19.783 177.546 27.245 1.00 33.48 c
ATOM 4564 CA CYS 467 19.573 177.007 28.580 1.00 33.48 c
ATOM 4565 CB CYS 467 20.638 175.950 28.901 1.00 33.48 c
ATOM 4566 SG CYS 467 20.233 174.908 30.345 1.00 33.48 c
ATOM 4567 C CYS 467 19.567 178.115 29.635 1.00 33.48 c
ATOM 4568 0 CYS 467 18.785 178.056 30.591 1.00 33.48 c
ATOM 4569 N GLU 468 20.448 179.108 29.473 1.00 33.48 c
ATOM 4570 CA GLU 468 20.493 180.248 30.394 1.00 33.48 c ATOM 4571 CB GLU 468 21.530 181.283 29.945 1.0033,.48 c
ATOM 4572 CG GLU 468 22.960 180.907 30.265 1.00 33, .48 c
ATOM 4573 CD GLU 468 23.975 181.605 29.370 1.00 33, .48 c
ATOM 4574 OEl GLU 468 23.866 181.454 28.136 1.00 33, .48 c
ATOM 4575 OE2 GLU 468 24.890 182.292 29.884 1.00 33, .48 c
ATOM 4576 C GLU 468 19.096 180.844 30.300 1.00 33, .48 c
ATOM 4577 O GLU 468 18.513 181.267 31.292 1.00 33, .48 c
ATOM 4578 N GLY 469 18.564 180.855 29.085 1.00 33 .48 c
ATOM 4579 CA GLY 469 17.227 181.358 28.879 1.00 33 .48 c
ATOM 4580 C GLY 469 16.274 180.539 29.716 1.00 33, .48 c
ATOM 4581 O GLY 469 15.982 180.911 30.840 1.00 33 .48 c
ATOM 4582 N MET 470 15.811179.416 29.169 1.00 33 .48 c
ATOM 4583 CA MET 470 14.878 178.499 29.843 1.00 33 .48 c
ATOM 4584 CB MET 470 14.956 177.125 29.200 1.00 33, .48 c
ATOM 4585 CG MET 470 14.742 177.155 27.717 1.00 33, .48 c
ATOM 4586 SD MET 470 13.190177.963 27.335 1.00 33 .48 c
ATOM 4587 CE MET 470 11.957 176.729 27.984 1.00 33 .48 c
ATOM 4588 C MET 470 15.046 178.339 31.355 1.00 33, .48 c
ATOM 4589 0 MET 470 14.121177.908 32.024 1.00 33, .48 c
ATOM 4590 N ALA 471 16.227 178.646 31.888 1.00 33 .48 c
ATOM 4591 CA ALA 471 16.437 178.557 33.329 1.00 33 .48 c
ATOM 4592 CB ALA 471 17.890 178.886 33.682 1.00 33, .48 c
ATOM 4593 C ALA 471 15.504 179.631 33.877 1.00 33 .48 c
ATOM 4594 0 ALA 471 14.578 179.357 34.653 1.00 33 .48 c
ATOM 4595 N TYR 472 15.765 180.861 33.443 1.00 33 .48 c
ATOM 4596 CA TYR 472 14.979 182.025 33.798 1.00 33 .48 c
ATOM 4597 CB TYR 472 15.288 183.122 32.795 1.00 33 .48 c
ATOM 4598 CG TYR 472 14.456 184.365 32.922 1.00 33 .48 c
ATOM 4599 CDl TYR 472 14.901185.461 33.670 1.00 33 .48 c
ATOM 4600 CEl TYR 472 14.159 186.632 33.731 1.00 33 .48 c
ATOM 4601 CD2 TYR 472 13.243 184.475 32.247 1.00 33 .48 c
ATOM 4602 CE2 TYR 472 12.495 185.642 32.303 1.00 33 .48 c
ATOM 4603 CZ TYR 472 12.958 186.715 33.039 1.00 33 .48 c
ATOM 4604 OH TYR 472 12.233 187.878 33.037 1.00 33, .48 c
ATOM 4605 C TYR 472 13.520181.609 33.705 1.00 33 .48 c
ATOM 4606 0 TYR 472 12.838 181.476 34.713 1.00 33 .48 c
ATOM 4607 N LEU 473 13.051181.368 32.490 1.00 33 .48 c
ATOM 4608 CA LEU 473 11.662 180.961 32.302 1.00 33, .48 c
ATOM 4609 CB LEU 473 11.454 180.381 30.897 1.00 33, .48 c
ATOM 4610 CG LEU 473 11.459 181.301 29.677 1.00 33 .48 c
ATOM 4611 CDl LEU 473 11.100 180.488 28.447 1.00 33 .48 c
ATOM 4612 CD2 LEU 473 10.452 182.431 29.871 1.00 33, .48 c
ATOM 4613 C LEU 473 11.197 179.934 33.337 1.00 33, .48 c
ATOM 4614 0 LEU 473 10.060 179.998 33.829 1.00 33 .48 c ATOM 4615 N GLU 474 12.084 178.994 33.659 1.0033,.48 c
ATOM 4616 CA GLU 474 11.788 177.915 34.603 1.00 33, .48 c
ATOM 4617 CB GLU 474 12.956 176.929 34.667 1.00 33, .48 c
ATOM 4618 CG GLU 474 12.789 175.783 35.655 1.00 33, .48 c
ATOM 4619 CD GLU 474 13.906 174.750 35.529 1.00 33, .48 c
ATOM 4620 OEl GLU 474 15.062 175.061 35.924 1.00 33, .48 c
ATOM 4621 OE2 GLU 474 13.626173.630 35.016 1.00 33, .48 c
ATOM 4622 C GLU 474 11.489 178.433 35.996 1.00 33, .48 c
ATOM 4623 O GLU 474 10.527 177.988 36.641 1.00 33, .48 c
ATOM 4624 N GLU 475 12.310 179.368 36.464 1.00 33, .48 c
ATOM 4625 CA GLU 475 12.109 179.938 37.794 1.00 33, .48 c
ATOM 4626 CB GLU 475 13.227 180.918 38.125 1.00 33, .48 c
ATOM 4627 CG GLU 475 13.154 181.432 39.521 1.00 33, .48 c
ATOM 4628 CD GLU 475 14.317 182.332 39.836 1.00 33, .48 c
ATOM 4629 OEl GLU 475 15.461 181.941 39.486 1.00 33 .48 c
ATOM 4630 OE2 GLU 475 14.096183.419 40.438 1.00 33, .48 c
ATOM 4631 C GLU 475 10.759 180.659 37.880 1.00 33, .48 c
ATOM 4632 O GLU 475 9.950 180.406 38.774 1.00 33, .48 c
ATOM 4633 N ALA 476 10.526 181.557 36.932 1.00 33 .48 c
ATOM 4634 CA ALA 476 9.290 182.311 36.882 1.00 33 .48 c
ATOM 4635 CB ALA 476 9.315 183.275 35.692 1.00 33, .48 c
ATOM 4636 C ALA 476 8.076 181.393 36.785 1.00 33, .48 c
ATOM 4637 O ALA 476 6.942 181.857 36.847 1.00 33, .48 c
ATOM 4638 N CYS 477 8.300 180.097 36.628 1.00 33, .48 c
ATOM 4639 CA CYS 477 7.181179.181 36.523 1.00 33, .48 c
ATOM 4640 CB CYS 477 6.250 179.333 37.710 1.00 33, .48 c
ATOM 4641 SG CYS 477 7.135 179.360 39.255 1.00 33, .48 c
ATOM 4642 C CYS 477 6.409 179.504 35.267 1.00 33, .48 c
ATOM 4643 O CYS 477 5.183 179.408 35.235 1.00 33 .48 c
ATOM 4644 N VAL 478 7.125 179.913 34.232 1.00 33, .48 c
ATOM 4645 CA VAL 478 6.479 180.223 32.971 1.00 33, .48 c
ATOM 4646 CB VAL 478 7.134 181.428 32.286 1.00 33 .48 c
ATOM 4647 CGl VAL 478 6.371181.804 31.023 1.00 33 .48 c
ATOM 4648 CG2 VAL 478 7.193 182.583 33.262 1.00 33 .48 c
ATOM 4649 C VAL 478 6.726 178.992 32.142 1.00 33, .48 c
ATOM 4650 O VAL 478 7.868 178.640 31.882 1.00 33 .48 c
ATOM 4651 N ILE 479 5.669 178.315 31.741 1.00 33 .48 c
ATOM 4652 CA ILE 479 5.864 177.120 30.949 1.00 33 .48 c
ATOM 4653 CB ILE 479 4.759 176.074 31.201 1.00 33, .48 c
ATOM 4654 CG2 ILE 479 4.994 174.865 30.313 1.00 33, .48 c
ATOM 4655 CGl ILE 479 4.736 175.679 32.675 1.00 33, .48 c
ATOM 4656 CDl ILE 479 3.645 174.670 33.029 1.00 33, .48 c
ATOM 4657 C ILE 479 5.891 177.411 29.454 1.00 33, .48 c
ATOM 4658 O ILE 479 4.839 177.474 28.806 1.00 33, .48 c ATOM 4659 N HIS 480 7.083 177.597 28.896 1.00 33,.48 c
ATOM 4660 CA HIS 480 7.170177.810 27.462 1.00 33, .48 c
ATOM 4661 CB HIS 480 8.628 177.895 27.028 1.00 33, .48 c
ATOM 4662 CG HIS 480 8.798 178.363 25.622 1.00 33, .48 c
ATOM 4663 CD2 HIS 480 9.620 179.295 25.085 1.00 33, .48 c
ATOM 4664 NDl HIS 480 8.024 177.886 24.585 1.00 33, .48 c
ATOM 4665 CEl HIS 480 8.357 178.510 23.469 1.00 33, .48 c
ATOM 4666 NE2 HIS 480 9.322 179.372 23.746 1.00 33, .48 c
ATOM 4667 C HIS 480 6.577 176.488 27.017 1.00 33, .48 c
ATOM 4668 0 HIS 480 6.574175.549 27.815 1.00 33, .48 c
ATOM 4669 N ARG 481 6.046176.375 25.805 1.00 33 .48 c
ATOM 4670 CA ARG 481 5.501175.064 25.406 1.00 33, .48 c
ATOM 4671 CB ARG 481 4.028 174.951 25.807 1.00 33, .48 c
ATOM 4672 CG ARG 481 3.820175.274 27.276 1.00 33, .48 c
ATOM 4673 CD ARG 481 2.445 174.913 27.796 1.00 33 .48 c
ATOM 4674 NE ARG 481 1.360175.550 27.060 1.00 33, .48 c
ATOM 4675 CZ ARG 481 0.092 175.542 27.456 1.00 33, .48 c
ATOM 4676 NHl ARG 481 -0.258 174.931 28.589 1.00 33, .48 c
ATOM 4677 NH2 ARG 481 -0.825 176.155 26.716 1.00 33, .48 c
ATOM 4678 C ARG 481 5.684 174.736 23.933 1.00 33 .48 c
ATOM 4679 0 ARG 481 4.951173.936 23.347 1.00 33, .48 c
ATOM 4680 N ASP 482 6.697 175.363 23.353 1.00 33, .48 c
ATOM 4681 CA ASP 482 7.024 175.172 21.963 1.00 33 .48 c
ATOM 4682 CB ASP 482 6.275 176.172 21.095 1.00 33 .48 c
ATOM 4683 CG ASP 482 5.423 175.492 20.060 1.00 33, .48 c
ATOM 4684 ODl ASP 482 5.125 176.115 19.018 1.00 33 .48 c
ATOM 4685 OD2 ASP 482 5.049 174.322 20.300 1.00 33 .48 c
ATOM 4686 C ASP 482 8.513 175.353 21.788 1.00 33 .48 c
ATOM 4687 0 ASP 482 8.969 175.858 20.774 1.00 33 .48 c
ATOM 4688 N LEU 483 9.267 174.944 22.799 1.00 33, .48 c
ATOM 4689 CA LEU 483 10.717 175.031 22.753 1.00 33 .48 c
ATOM 4690 CB LEU 483 11.323 174.421 24.005 1.00 33 .48 c
ATOM 4691 CG LEU 483 12.811174.687 24.192 1.00 33 .48 c
ATOM 4692 CDl LEU 483 13.579174.239 22.964 1.00 33 .48 c
ATOM 4693 CD2 LEU 483 13.029 176.169 24.439 1.00 33, .48 c
ATOM 4694 C LEU 483 11.195 174.248 21.539 1.00 33 .48 c
ATOM 4695 0 LEU 483 11.085 173.035 21.501 1.00 33 .48 c
ATOM 4696 N ALA 484 11.725 174.957 20.553 1.00 33 .48 c
ATOM 4697 CA ALA 484 12.217174.343 19.337 1.00 33 .48 c
ATOM 4698 CB ALA 484 11.074 174.091 18.370 1.00 33 .48 c
ATOM 4699 C ALA 484 13.246 175.271 18.713 1.00 33 .48 c
ATOM 4700 0 ALA 484 13.419 176.405 19.142 1.00 33 .48 c
ATOM 4701 N ALA 485 13.944174.770 17.705 1.00 33 .48 c
ATOM 4702 CA ALA 485 14.961175.544 17.032 1.00 33 .48 c ATOM 4703 CB ALA 485 15.835 174.627 16.201 1.00 33.48 C
ATOM 4704 C ALA 485 14.280 176.576 16.156 1.00 33.48 C
ATOM 4705 O ALA 485 14.814 177.667 15.938 1.00 33 .48 C
ATOM 4706 N ARG 486 13.0g5 176.230 15.661 1.00 33.48 C
ATOM 4707 CA ARG 486 12.324 177.137 14.817 1.00 33 .48 C
ATOM 4708 CB ARG 486 11.280 176.373 13.991 1.00 33 .48 C
ATOM 4709 CG ARG 486 10.159 175.763 14.822 1.00 33 .48 C
ATOM 4710 CD ARG 486 8.911175.497 13.991 1.00 33 .48 C
ATOM 4711 NE ARG 486 8.6g6 174.076 13.692 1.00 33.48 C
ATOM 4712 CZ ARG 486 8.431173.124 14.5g6 1.00 33 .48 C
ATOM 4713 NHl ARG 486 8.33g 173.409 15.8g3 1.00 33 .48 C
ATOM 4714 NH2 ARG 486 8.256 171.869 14.191 1.00 33 .48 C
ATOM 4715 C ARG 486 11.609 178.159 15.698 1.00 33 .48 C
ATOM 4716 0 ARG 486 10.780 178.928 15.216 1.00 33 .48 C
ATOM 4717 N ASN 487 11.919 178.156 16.98g 1.00 33 .48 C
ATOM 4718 CA ASN 487 11.310 179.092 17.922 1.00 33 .48 C
ATOM 4719 CB ASN 487 10.324 178.379 18.842 1.00 33 .48 C
ATOM 4720 CG ASN 487 9.107 177.885 18.106 1.00 33 .48 C
ATOM 4721 ODl ASN 487 8.786 178.377 17.026 1.00 33 .48 c
ATOM 4722 ND2 ASN 487 8.408 176.923 18.688 1.00 33 .48 c
ATOM 4723 C ASN 487 12.388 179.771 18.741 1.00 33.48 c
ATOM 4724 0 ASN 487 12.189 180. ogg 19.919 1.00 33 .48 c
ATOM 4725 N CYS 488 13.530 179.97g 18.095 1.00 33 .48 c
ATOM 4726 CA CYS 488 14.67g 180.626 18.706 1.00 33 .48 c
ATOM 4727 CB CYS 488 15.720 179.577 19.104 1.00 33 .48 c
ATOM 4728 SG CYS 488 15.244 178.601 20.523 1.00 33 .48 c
ATOM 472g C CYS 488 15.255 181.580 17.667 1.00 33 .48 c
ATOM 4730 0 CYS 488 15.115 181.346 16.472 1.00 33.48 c
ATOM 4731 N LEU 48 15.g07 182.648 is.ogg 1.00 33 .48 c
ATOM 4732 CA LEU 48 16.438 183.587 17.133 1.00 33 .48 c
ATOM 4733 CB LEU 48 15.758 184.942 17.321 1.00 33 .48 c
ATOM 4734 CG LEU 489 14.254 184.89g 17.052 1.00 33 .48 c
ATOM 4735 CDl LEU 489 13.586 185. ggs 17.805 1.00 33 .48 c
ATOM 4736 CD2 LEU 489 13.g78 184.991 15.568 1.00 33 .48 c
ATOM 4737 C LEU 489 17.g32 183.716 17.261 1.00 33 .48 c
ATOM 4738 0 LEU 489 18.487 183.493 18.334 1.00 33.48 c
ATOM 473g N VAL 490 18.577 184.064 16.153 1.00 33 .48 c
ATOM 4740 CA VAL 490 20.022 184.231 16.117 1.00 33 .48 c
ATOM 4741 CB VAL 490 20.662 183.345 15.047 1.00 33 .48 c
ATOM 4742 CGl VAL 490 22.174 183.416 15.161 1.00 33 .48 c
ATOM 4743 CG2 VAL 490 20.155 181.927 15.179 1.00 33 .48 c
ATOM 4744 C VAL 490 20.402 185.676 15.802 1.00 33.48 c
ATOM 4745 0 VAL 490 20.054 186.194 14.740 1.00 33 .48 c
ATOM 4746 N GLY 491 21.135 186.312 16.713 1.00 33 .48 c ATOM 4747 CA GLY 491 21.534 187.684 16.497 1.00 33.48 c
ATOM 4748 c GLY 491 23.022 187.965 16.514 1.00 33.48 c
ATOM 474g O GLY 491 23.836 187.114 16.189 1.00 33.48 c
ATOM 4750 N GLU 492 23.354 189.196 16.902 1.00 33.48 c
ATOM 4751 CA GLU 492 24.725 189.709 16.981 1.00 33.48 c
ATOM 4752 CB GLU 492 24.760 190.939 17.892 1.00 33.48 c
ATOM 4753 CG GLU 492 25.993 191.801 17.723 1.00 33.48 c
ATOM 4754 CD GLU 492 25.892 193.131 18.468 1.00 33.48 c
ATOM 4755 OEl GLU 492 26.850 193. g40 18.345 1.00 33.48 c
ATOM 4756 OE2 GLU 492 24.862 193.366 19.169 1.00 33.48 c
ATOM 4757 C GLU 492 25.707 188.657 17.480 1.00 33.48 c
ATOM 4758 O GLU 492 25.564 188.114 18.577 1.00 33.48 c
ATOM 475g N ASN 493 26.722 188.394 16.669 1.00 33.48 c
ATOM 4760 CA ASN 493 27.6gθ 187.380 17.007 1.00 33.48 c
ATOM 4761 CB ASN 493 28.666 187.875 18.052 1.00 33.48 c
ATOM 4762 CG ASN 493 29.732 188.748 17.449 1.00 33.48 c
ATOM 4763 ODl ASN 493 29.511 189.937 17.20g 1.00 33.48 c
ATOM 4764 ND2 ASN 493 30.897 188.156 17.164 1.00 33.48 c
ATOM 4765 C ASN 493 26.955 186.168 17.504 1.00 33.48 c
ATOM 4766 0 ASN 493 26.9g8 185/815 18.673 1.00 33.48 c
ATOM 4767 N GLN 494 26.230 185.561 16.5g2 1.00 33.48 c
ATOM 4768 CA GLN 494 25.4g8 184.358 16.878 1.00 33.48 c
ATOM 476g CB GLN 494 26.425 183.171 16.662 1.00 33.48 c
ATOM 4770 CG GLN 494 27.216 183.285 15.374 1.00 33.48 c
ATOM 4771 CD GLN 494 28.043 182.066 15.0g2 1.00 33.48 c
ATOM 4772 OEl GLN 494 28.7g3 181.595 15.g47 1.00 33.48 c
ATOM 4773 NE2 GLN 494 27. ig 181.543 13.887 1.00 33.48 c
ATOM 4774 C GLN 494 24.810 184.224 18.226 1.00 33.48 c
ATOM 4775 O GLN 494 24.381 183.127 18.562 1.00 33.48 c
ATOM 4776 N VAL 495 24.680 185.284 19.014 1.00 33.48 c
ATOM 4777 CA VAL 495 23. 7g 185.100 20.282 1.00 33.48 c
ATOM 4778 CB VAL 495 23.668 186.406 20.972 1.00 33.48 c
ATOM 477g CGl VAL 495 22.711186.150 22.128 1.00 33.48 c
ATOM 4780 CG2 VAL 495 24.g54 187.032 21.475 1.00 33.48 c
ATOM 4781 C VAL 495 22.654 184.436 19.971 1.00 33.48 c
ATOM 4782 O VAL 495 22.035 184.758 18.967 1.00 33.48 c
ATOM 4783 N ILE 496 22.217 183.507 20.812 1.00 33.48 c
ATOM 4784 CA ILE 496 20.945 182.832 20.563 1.00 33.48 c
ATOM 4785 CB ILE 496 21.123 181.302 20.4gi 1.00 33.48 c
ATOM 4786 CG2 ILE 496 19.801 180.637 20.165 1.00 33.48 c
ATOM 4787 CGl ILE 496 22.14g 180.948 19.418 1.00 33.48 c
ATOM 4788 CDl ILE 496 21.785 181.465 18.063 1.00 33.48 c
ATOM 4789 C ILE 496 ιg.g2g 183.152 21.644 1.00 33.48 c
ATOM 4790 O ILE 496 20.225 183.011 22.825 1.00 33.48 c ATOM 47gι N LYS 497 18.737 183.584 21.235 1.00 33.48 C
ATOM 47g2 CA LYS 497 17.66 183. g26 22.181 1.00 33.48 C
ATOM 47g3 CB LYS 497 17.37g 185.414 22.141 1.00 33 .48 C
ATOM 47g4 CG LYS 497 18.512 186.291 22.532 1.00 33 .48 C
ATOM 47 5 CD LYS 4g7 18.063 187.727 22.453 1.00 33 .48 C
ATOM 47g6 CE LYS 497 ig.083 188.667 23.017 1.00 33.48 C
ATOM 47g7 NZ LYS 497 18.460 igθ.007 23.094 1.00 33 .48 C
ATOM 47g8 C LYS 4g7 16.358 183.198 21.899 1.00 33 .48 C
ATOM 4799 0 LYS 4g7 16.083 182.805 20.763 1.00 33.48 C
ATOM 4800 N VAL 48 15.540183.042 22.g35 1.00 33 .48 C
ATOM 4801 CA VAL 498 14.254 182.375 22.788 1.00 33 .48 C
ATOM 4802 CB VAL 498 13.791181.758 24.125 1.00 33 .48 C
ATOM 4803 CGl VAL 4g8 12.424181.100 23.g71 1.00 33 .48 C
ATOM 4804 CG2 VAL 4g8 14.7g6 180.729 24.584 1.00 33 .48 C
ATOM 4805 C VAL 48 13.198 183.371 22.324 1.00 33 .48 C
ATOM 4806 0 VAL 4gδ 13.437 184.572 22.2g2 1.00 33 .48 C
ATOM 4807 N SER 4gg 12.033 182.874 21.942 1.00 33 .48 C
ATOM 4808 CA SER 4gg 10.g53 183.749 21.537 1.00 33 .48 c
ATOM 4809 CB SER 4 g 11.215 184.332 20.153 1.00 33 .48 c
ATOM 4810 OG SER 4gg 11.306183.325 19.176 1.00 33 .48 c
ATOM 4811 C SER 4gg g.653 182. 62 21.546 1.00 33.48 c
ATOM 4812 0 SER 4gg 9.667 181.717 21.649 1.00 33 .48 c
ATOM 4813 N ASP 500 8.541183.6g8 21.465 1.00 33 .48 c
ATOM 4814 CA ASP 500 7.188 183.134 21.437 1.00 33 .48 c
ATOM 4815 CB ASP 500 7.217 181.603 21.277 1.00 33 .48 c
ATOM 4816 CG ASP 500 7.486 181.182 19.850 1.00 33.48 c
ATOM 4817 ODl ASP 500 8.545 181.582 19.307 1.00 33.48 c
ATOM 4818 OD2 ASP 500 6.634180.457 19.270 1.00 33 .48 c
ATOM 4819 C ASP 500 6.374183.505 22.668 1.00 33 .48 c
ATOM 4820 0 ASP 500 6.09g 184.683 22.gog 1.00 33.48 c
ATOM 4821 N PHE 501 5.981 182.4gg 23.444 1.00 33 .48 c
ATOM 4822 CA PHE 501 5.209 182.752 24.648 1.00 33 .48 c
ATOM 4823 CB PHE 501 5.919 183.7 5 25.508 1.00 33 .48 c
ATOM 4824 CG PHE 501 7.381183.524 25.67g 1.00 33 .48 c
ATOM 4825 CDl PHE 501 8.2g2 183.929 24.712 1.00 33 .48 c
ATOM 4826 CD2 PHE 501 7.840182.859 26.808 1.00 33 .48 c
ATOM 4827 CEl PHE 501 g.627 183.679 24.870 1.00 33 .48 c
ATOM 4828 CE2 PHE 501 9.167 182.604 26.g7g 1.00 33 .48 c
ATOM 4829 CZ PHE 501 10.071183.011 26.017 1.00 33 .48 c
ATOM 4830 C PHE 501 3.80g 183.243 24.326 1.00 33 .48 c
ATOM 4831 0 PHE 501 3.203 183.961 25.125 1.00 33.48 c
ATOM 4832 N GLY 502 3.2gg 182.843 23.163 1.00 33 .48 c
ATOM 4833 CA GLY 502 1.959183.247 22.756 1.00 33 .48 c
ATOM 4834 C GLY 502 0.844 182.588 23.556 1.00 33 .48 c ATOM 4835 O GLY 502 0.740 182.777 24.771 1.0033,.48 c
ATOM 4836 N PRO 521 3 . 627 168.4g7 15.579 1.00 33, .48 c
ATOM 4837 CD PRO 521 2 . 314 169.147 15.75g 1.00 33, .48 c
ATOM 4838 CA PRO 521 4. 587 169.013 16.557 1.00 33, .48 c
ATOM 4839 CB PRO 521 3.893 170.261 i7.ogo 1.00 33, .48 c
ATOM 4840 CG PRO 521 2 .461 169.814 17.147 1.00 33, .48 c
ATOM 4841 C PRO 521 4.879 168.013 17.671 1.00 33, .48 c
ATOM 4842 O PRO 521 5 .438 168.388 18.722 1.00 33, .48 c
ATOM 4843 N VAL 522 4. 507 166.750 17.451 1.00 33, .48 c
ATOM 4844 CA VAL 522 4.752 165.724 18.462 1.00 33 .48 c
ATOM 4845 CB VAL 522 4.085 164.393 18. og4 1.00 33, .48 c
ATOM 4846 CGl VAL 522 2. 586 164.582 17. g40 1.00 33, .48 c
ATOM 4847 CG2 VAL 522 4.695 163.853 16.811 1.00 33, .48 c
ATOM 4848 C VAL 522 6.250 165.484 18.625 1.00 33, .48 c
ATOM 4849 0 VAL 522 6.710 165.089 ιg.6gg 1.00 33, .48 c
ATOM 4850 N LYS 523 7.085 165.753 17.451 1.00 33, .48 c
ATOM 4851 CA LYS 523 8. 528 165.600 17.5gθ 1.00 33 .48 c
ATOM 4852 CB LYS 523 g.24g 166.131 16.355 1.00 33, .48 c
ATOM 4853 CG LYS 523 8.6g7 165.572 15.051 1.00 33 .48 c
ATOM 4854 CD LYS 523 9.778 165.333 14.017 1.00 33 .48 c
ATOM 4855 CE LYS 523 9.206 165.485 12.622 1.00 33, .48 c
ATOM 4856 NZ LYS 523 10.234 165.231 11.567 1.00 33 .48 c
ATOM 4857 C LYS 523 9.081166.28g 18. δog 1.00 33 .48 c
ATOM 4858 0 LYS 523 10.181 165. g85 ig.244 1.00 33 .48 c
ATOM 4859 N TRP 524 8.456 167.189 ιg.33g 1.00 33 .48 c
ATOM 4860 CA TRP 524 9.072 167.882 20.456 1.00 33 .48 c
ATOM 4861 CB TRP 524 9.125 169.378 20.15g 1.00 33 .48 c
ATOM 4862 CG TRP 524 10.226 169.746 19.210 1.00 33 .48 c
ATOM 4863 CD2 TRP 524 10.158 169.77g 17.778 1.00 33 .48 c
ATOM 4864 CE2 TRP 524 11.433 170.161 17.308 1.00 33, .48 c
ATOM 4865 CE3 TRP 524 9.144 16g.524 16.844 1.00 33 .48 c
ATOM 4866 CDl TRP 524 11.500 170. og4 19.53g 1.00 33, .48 c
ATOM 4867 NEl TRP 524 12.232 170.347 18.405 1.00 33 .48 c
ATOM 4868 CZ2 TRP 524 11.725 170.2g7 15.g45 1.00 33 .48 c
ATOM 4869 CZ3 TRP 524 g.440 169.661 15.478 1.00 33 .48 c
ATOM 4870 CH2 TRP 524 10.720 170.044 15.050 1.00 33 .48 c
ATOM 4871 C TRP 524 8.343 167.606 21.753 1.00 33 .48 c
ATOM 4872 0 TRP 524 8.87g 167.827 22.843 1.00 33 .48 c
ATOM 4873 N ALA 525 7.125 167.087 21.614 1.00 33 .48 c
ATOM 4874 CA ALA 525 6.254 166.749 22.738 1.00 33 .48 c
ATOM 4875 CB ALA 525 4. gig 166.269 22.204 1.00 33 .48 c
ATOM 4876 C ALA 525 6.826 165.693 23.671 1.00 33 .48 c
ATOM 4877 0 ALA 525 7. 35g 164.6g4 23.217 1.00 33 .48 c
ATOM 4878 N SER 526 6.718 165.909 24.g77 1.00 33, .48 c ATOM 487 CA SER 526 7.187 164.913 25.g43 1.00 33.48 C
ATOM 4880 CB SER 526 7.447 165.531 27.327 1.00 33.48 C
ATOM 4881 OG SER 526 6.251 166.020 27.g21 1.00 33.48 C
ATOM 4882 c SER 526 6.057 163.891 26.04g 1.00 33.48 C
ATOM 4883 0 SER 526 4.873 164.228 25.8g7 1.00 33.48 C
ATOM 4884 N PRO 527 6.402 162.636 26.350 1.00 33.48 C
ATOM 4885 CD PRO 527 7.580 162.261 27.154 1.00 33.48 C
ATOM 4886 CA PRO 527 5.361 161.614 26.452 1.00 33.48 C
ATOM 4887 CB PRO 527 6.043 160. sog 27.257 1.00 33.48 C
ATOM 4888 CG PRO 527 6.987 161.277 28.150 1.00 33.48 C
ATOM 488 C PRO 527 4.058 162. ogε 27.082 1.00 33.48 C
ATOM 48go O PRO 527 3.010 162. ogδ 26.422 1.00 33.48 C
ATOM 4891 N GLU 528 4.132 162.534 28.340 1.00 33.48 C
ATOM 4892 CA GLU 528 2.941 162. g68 2g.061 1.00 33.48 C
ATOM 4893 CB GLU 528 3.277 163.402 30.48g 1.00 33.48 c
ATOM 4894 CG GLU 528 3.9 5 164.712 30.564 1.00 33.48 c
ATOM 4895 CD GLU 528 5.491 164.545 30.442 1.00 33.48 c
ATOM 4896 OEl GLU 528 5.941 163.730 2g.58 1.00 33.48 c
ATOM 4897 OE2 GLU 528 6.215 165.237 31.196 1.00 33.48 c
ATOM 4898 C GLU 528 2.142 164.073 28.388 1.00 33.48 c
ATOM 4899 O GLU 528 0.907 164.081 28.474 1.00 33.48 c
ATOM 4900 N VAL 52g 2.811 165.008 27.717 1.00 33.48 c
ATOM 4901 CA VAL 52g 2.042 166.065 27.075 1.00 33.48 c
ATOM 4902 CB VAL 52g 2.928 167.225 26.50g 1.00 33.48 c
ATOM 4903 CGl VAL 52 3.98g 167.623 27.517 1.00 33.48 c
ATOM 4904 CG2 VAL 529 3.534 166.830 25.183 1.00 33.48 c
ATOM 4905 C VAL 529 1.222 165.477 25.g36 1.00 33.48 c
ATOM 406 O VAL 529 0.014 165.6gδ 25.883 1.00 33.48 c
ATOM 4g07 N PHE 530 1.864 164.707 25.051 1.00 33.48 c
ATOM 4g08 CA PHE 530 1.161 164.133 23.g02 1.00 33.48 c
ATOM 4gog CB PHE 530 2.147 163.746 22.784 1.00 33.48 c
ATOM 4gιo CG PHE 530 3.113 162.633 23.138 1.00 33.48 c
ATOM 4911 CDl PHE 530 2.665 161.329 23.332 1.00 33.48 c
ATOM 4 i2 CD2 PHE 530 4.4g5 162.889 23.210 1.00 33.48 c
ATOM 4gi3 CEl PHE 530 3.581 160.293 23.587 1.00 33.48 c
ATOM 4gi4 CE2 PHE 530 5.417 161.866 23.462 1.00 33.48 c
ATOM 4915 CZ PHE 530 4.g60 160.566 23.651 1.00 33.48 c
ATOM 4916 C PHE 530 0.203 162.975 24.161 1.00 33.48 c
ATOM 4917 O PHE 530 o.5gg 162.629 23.2gi 1.00 33.48 c
ATOM 4918 N SER 531 0.274 162.365 25.340 1.00 33.48 c
ATOM 49ig CA SER 531 0.652 161.273 25.647 1.00 33.48 c
ATOM 4g20 CB SER 531 0.074 160.087 26.281 1.00 33.48 c
ATOM 4g21 OG SER 531 0.873 159.107 26.680 1.00 33.48 c
ATOM 4g22 C SER 531 1.764 161.749 26.586 1.00 33.48 c ATOM 4g23 0 SER 531 2.g31 161.372 26.422 1.00 33.48 C
ATOM 4g24 N PHE 532 1.387 162.571 27.564 1.00 33.48 C
ATOM 4g25 CA PHE 532 2.324 163.124 28.535 1.00 33.48 C
ATOM 4 26 CB PHE 532 2.285 162.310 2g.82g 1.00 33.48 C
ATOM 4927 CG PHE 532 2.3 2 160.833 2g.617 1.00 33.48 C
ATOM 4928 CDl PHE 532 3.550 160.272 2g.097 1.00 33.48 C
ATOM 492g CD2 PHE 532 1.324 160.001 29.g04 1.00 33.48 c
ATOM 4 30 CEl PHE 532 3.643 158.893 28.860 1.00 33.48 c
ATOM 4g31 CE2 PHE 532 1.412 158.628 29.672 1.00 33.48 c
ATOM 4g32 CZ PHE 532 2.574 158.076 29.148 1.00 33.48 c
ATOM 4g33 C PHE 532 1.828 164.530 28.804 1.00 33.48 c
ATOM 4g34 0 PHE 532 1.162 164.767 2g.823 1.00 33.48 c
ATOM 4g35 N SER 533 2.145 165.450 27.884 1.00 33.48 c
ATOM 4g36 CA SER 533 1.717 166.871 27.g28 1.00 33.48 c
ATOM 4g37 CB SER 533 2.7g8 167.751 27.283 1.00 33.48 c
ATOM 4g38 OG SER 533 2.840 167.560 25.875 1.00 33.48 c
ATOM 4939 C SER 533 1.324 167.486 2g.280 1.00 33.48 c
ATOM 4940 0 SER 533 2.076 168.284 2g.836 1.00 33.48 c
ATOM 4941 N ARG 534 0.138 167.151 2g.788 1.00 33.48 c
ATOM 4g42 CA ARG 534 0.303 167.671 31.083 1.00 33.48 c
ATOM 443 CB ARG 534 0.538 166.506 32.058 1.00 33.48 c
ATOM 4g44 CG ARG 534 0.262 166.767 33.551 1.00 33.48 c
ATOM 4g45 CD ARG 534 0.951 168.012 34.114 1.00 33.48 c
ATOM 4g46 NE ARG 534 0.686 168.191 35.554 1.00 33.48 c
ATOM 4947 CZ ARG 534 0.531 168.330 36.108 1.00 33.48 c
ATOM 4948 NHl ARG 534 1.631 168.317 35.351 1.00 33.48 c
ATOM 494g NH2 ARG 534 0.657 168.466 37.433 1.00 33.48 c
ATOM 4g50 C ARG 534 1.600 168.446 30.g20 1.00 33.48 c
ATOM 4 51 0 ARG 534 2.673 167.891 31.145 1.00 33.48 c
ATOM 4952 N TYR 535 1.513 169.720 30.536 1.00 33.48 c
ATOM 4953 CA TYR 535 2.724 170.539 30.357 1.00 33.48 c
ATOM 4954 CB TYR 535 2.379 171.913 2g.763 1.00 33.48 c
ATOM 4955 CG TYR 535 2.000 171.809 28.307 1.00 33.48 c
ATOM 4956 CDl TYR 535 2.972 171.608 27.335 1.00 33.48 c
ATOM 4957 CEl TYR 535 2.631 171.367 26.007 1.00 33.48 c
ATOM 4958 CD2 TYR 535 0.671 171.785 27.gi5 1.00 33.48 c
ATOM 495 CE2 TYR 535 0.317 171.547 26.5g4 1.00 33.48 c
ATOM 4g60 CZ TYR 535 1.300 171.331 25.640 1.00 33.48 c
ATOM 4g61 OH TYR 535 0.953 171.037 24.328 1.00 33.48 c
ATOM 4 62 C TYR 535 3.472 170.703 31.661 1.00 33.48 c
ATOM 4g63 0 TYR 535 3.000 170.267 32.711 1.00 33.48 c
ATOM 4 64 N SER 536 4.650 171.309 31.588 1.00 33.48 c
ATOM 4g65 CA SER 536 5.468 171.519 32.780 1.00 33.48 c
ATOM 4 66 CB SER 536 5.475 170.260 33.665 1.00 33.48 c ATOM 467 OG SER 536 5.313 169.068 32.904 1.0033,.48 c
ATOM 4968 C SER 536 6.896 171.900 32.456 1.00 33, .48 c
ATOM 496g O SER 536 7.414 171. sgg 31.381 1.00 33, .48 c
ATOM 4970 N SER 537 7. 537 172.566 33.403 1.00 33, .48 c
ATOM 4971 CA SER 537 8.916 172.977 33.209 1.00 33, .48 c
ATOM 4972 CB SER 537 9. 510173.502 34.521 1.00 33, .48 c
ATOM 4973 OG SER 537 10.832 173.980 34.333 1.00 33, .48 c
ATOM 4974 C SER 537 9.6g9 171.767 32.723 1.00 33 .48 c
ATOM 4975 O SER 537 10.715 171.918 32.051 1.00 33, .48 c
ATOM 4976 N LYS 538 9.207 170.571 33.056 1.00 33, .48 c
ATOM 4977 CA LYS 538 g.854 169.323 32.651 1.00 33 .48 c
ATOM 4978 CB LYS 538 g.36g 168.140 33.500 1.00 33 .48 c
ATOM 4979 CG LYS 538 g.992 168.075 34.903 1.00 33 .48 c
ATOM 4980 CD LYS 538 11.514 168.247 34.856 1.00 33 .48 c
ATOM 4g81 CE LYS 538 12.169 167. g63 36.208 1.00 33 .48 c
ATOM 4g82 NZ LYS 538 13.566 168.471 36.271 1.00 33 .48 c
ATOM 4g83 C LYS 538 9.603 16g.031 31.195 1.00 33 .48 c
ATOM 4g84 0 LYS 538 10.533 168.746 30.458 1.00 33 .48 c
ATOM 4 85 N SER 539 8.344 16g.090 30.785 1.00 33, .48 c
ATOM 4g86 CA SER 539 7.992 168.857 29.385 1.00 33, .48 c
ATOM 4g87 CB SER 539 6.512 169.162 29.143 1.00 33, .48 c
ATOM 4g88 OG SER 539 6.331 169.704 27.843 1.00 33 .48 c
ATOM 4989 C SER 539 8.832 169.771 28.502 1.00 33, .48 c
ATOM 49 o O SER 539 9.065 169.487 27.329 1.00 33, .48 c
ATOM 4991 N ASP 540 g.264 170.887 29.077 1.00 33, .48 c
ATOM 49 2 CA ASP 540 10.087 171.842 28.356 1.00 33, .48 c
ATOM 4g 3 CB ASP 540 10.071 173.195 29.074 1.00 33, .48 c
ATOM 4gg4 CG ASP 540 8.g77 174.122 28.546 1.00 33, .48 c
ATOM 4g95 ODl ASP 540 7.939 173.583 28.110 1.00 33 .48 c
ATOM 49 6 OD2 ASP 540 9.148 175.374 28.573 1.00 33, .48 c
ATOM 4g97 C ASP 540 11.507 171.301 28.260 1.00 33 .48 c
ATOM 4998 O ASP 540 12.271 171.712 27.392 1.00 33, .48 c
ATOM 499 N VAL 541 11.848 170.381 29.164 1.00 33 .48 c
ATOM 5000 CA VAL 541 13.162 169.757 29.196 1.00 33, .48 c
ATOM 5001 CB VAL 541 13.414 169.037 30.520 1.00 33, .48 c
ATOM 5002 CGl VAL 541 14.855 168.537 30.569 1.00 33, .48 c
ATOM 5003 CG2 VAL 541 13.114 169. g57 31.677 1.00 33, .48 c
ATOM 5004 C VAL 541 13.207 168.719 28.091 1.00 33, .48 c
ATOM 5005 O VAL 541 14.219 168.555 27.412 1.00 33, .48 c
ATOM 5006 N TRP 542 12.106 168.003 27.920 1.00 33, .48 c
ATOM 5007 CA TRP 542 12.036 167.008 26.865 1.00 33, .48 c
ATOM 5008 CB TRP 542 10.683 166.288 26.876 1.00 33, .48 c
ATOM 5009 CG TRP 542 10.52g 165.316 25.750 1.00 33, .48 c
ATOM 5010 CD2 TRP 542 10.627 163.889 25.834 1.00 33, ,48 c ATOM 5011 CE2 TRP 542 10.487 163.383 24.526 1.00 33,.48 c
ATOM 5012 CE3 TRP 542 10.820 162. g85 26.893 1.00 33, .48 c
ATOM 5013 CDl TRP 542 10.332 165.608 24.433 1.00 33, .48 c
ATOM 5014 NEl TRP 542 10.309 164.452 23.689 1.00 33, .48 c
ATOM 5015 CZ2 TRP 542 10.534 162.013 24.246 1.00 33, .48 c
ATOM 5016 CZ3 TRP 542 10.865 161.625 26.612 1.00 33, .48 c
ATOM 5017 CH2 TRP 542 10.723 161.154 25.302 1.00 33, .48 c
ATOM 5018 C TRP 542 12.217 167.741 25.541 1.00 33, .48 c
ATOM soig O TRP 542 12.705 167.166 24.572 1.00 33, .48 c
ATOM 5020 N SER 543 11.818 169.011 25.505 1.00 33, .48 c
ATOM 5021 CA SER 543 11.944 16g.808 24.294 1.00 33, .48 c
ATOM 5022 CB SER 543 10.g95 171.008 24.345 1.00 33, .48 c
ATOM 5023 OG SER 543 9.664 170.655 23.984 1.00 33, .48 c
ATOM 5024 C SER 543 13.373 170.2go 24.098 1.00 33, .48 c
ATOM 5025 O SER 543 13.862 170.355 22.g76 1.00 33, .48 c
ATOM 5026 N PHE 544 14.047 170.633 25.18g 1.00 33, .48 c
ATOM 5027 CA PHE 544 15.421 171. og2 25.ogo 1.00 33, .48 c
ATOM 5028 CB PHE 544 15.985 171.415 26.46g 1.00 33, .48 c
ATOM 502g CG PHE 544 17.322 172.114 26.430 1.00 33, .48 c
ATOM 5030 CDl PHE 544 17.487 173.2g2 25.6g7 1.00 33, .48 c
ATOM 5031 CD2 PHE 544 18.411171.610 27.134 1.00 33, .48 c
ATOM 5032 CEl PHE 544 18.715 173.951 25.66g 1.00 33, .48 c
ATOM 5033 CE2 PHE 544 19.637 172.266 27. iog 1.00 33, .48 c
ATOM 5034 CZ PHE 544 19.786 173.439 26.374 1.00 33, .48 c
ATOM 5035 C PHE 544 16.208 169. 47 24.484 1.00 33, .48 c
ATOM 5036 0 PHE 544 17.164 170.160 23.729 1.00 33, .48 c
ATOM 5037 N GLY 545 15.795 168.727 24.829 1.00 33, .48 c
ATOM 5038 CA GLY 545 16.460 167.548 24.320 1.00 33, .48 c
ATOM 5039 C GLY 545 16.575 167.636 22.820 1.00 33, .48 c
ATOM 5040 0 GLY 545 17.677 167.671 22.271 1.00 33, .48 c
ATOM 5041 N VAL 546 15.425 167.702 22.160 1.00 33, .48 c
ATOM 5042 CA VAL 546 15.367 167.775 20.710 1.00 33, .48 c
ATOM 5043 CB VAL 546 13.919 167.742 20.212 1.00 33, .48 c
ATOM 5044 CGl VAL 546 13.897 167.563 18.712 1.00 33, .48 c
ATOM 5045 CG2 VAL 546 13.159 166.6ig 20.898 1.00 33, .48 c
ATOM 5046 C VAL 546 16.047 16g.030 20.189 1.00 33, .48 c
ATOM 5047 0 VAL 546 16.600 169.032 19.088 1.00 33, .48 c
ATOM 5048 N LEU 547 16.012 170.106 20.964 1.00 33, .48 c
ATOM 5049 CA LEU 547 16.678 171.313 20.506 1.00 33, ,48 c
ATOM 5050 CB LEU 547 16.467 172.474 21.479 1.00 33, .48 c
ATOM 5051 CG LEU 547 16.967 173.828 20.961 1.00 33, .48 c
ATOM 5052 CDl LEU 547 15.784 174.717 20.685 1.00 33, ,48 c
ATOM 5053 CD2 LEU 547 17.871 174.488 21.978 1.00 33, .48 c
ATOM 5054 C LEU 547 18.160 170.955 20.424 1.00 33, .48 c ATOM 5055 0 LEU 547 18.785 171.107 19.377 1.00 33.48 C
ATOM 5056 N MET 548 18.718 170.461 21.524 1.00 33.48 C
ATOM 5057 CA MET 548 20.120 170.068 21.531 1.00 33.48 C
ATOM 5058 CB MET 548 20.442 169.232 22.770 1.00 33.48 C
ATOM 505g CG MET 548 20.292 16g.g62 24.075 1.00 33.48 C
ATOM 5060 SD MET 548 21.015 168. gg2 25.382 1.00 33.48 C
ATOM 5061 CE MET 548 22.675 16g.464 25.235 1.00 33.48 C
ATOM 5062 C MET 548 20.418 16g.230 20.290 1.00 33.48 C
ATOM 5063 0 MET 548 21.403 16g.463 19.577 1.00 33.48 C
ATOM 5064 N TRP 549 19.566 168.238 20.053 1.00 33.48 C
ATOM 5065 CA TRP 549 19.738 167.378 18.897 1.00 33.48 C
ATOM 5066 CB TRP 549 18.550 166.431 18.740 1.00 33.48 C
ATOM 5067 CG TRP 549 18.785 165.364 17.724 1.00 33.48 C
ATOM 5068 CD2 TRP 549 18.313 165.344 16.371 1.00 33.48 C
ATOM 506g CE2 TRP 549 18.824 164.178 15.770 1.00 33.48 c
ATOM 5070 CE3 TRP 549 17.509 166.203 15.608 1.00 33.48 c
ATOM 5071 CDl TRP 549 19.536 164.243 17.881 1.00 33.48 c
ATOM 5072 NEl TRP 549 19.566 163.525 16.714 1.00 33.48 c
ATOM 5073 CZ2 TRP 549 18.562 163.843 14.447 1.00 33.48 c
ATOM 5074 CZ3 TRP 549 17.245 165.871 14.286 1.00 33.48 c
ATOM 5075 CH2 TRP 549 17.772 164.6gg 13.720 1.00 33.48 c
ATOM 5076 C TRP 54g 19.844 168.277 17.671 1.00 33.48 c
ATOM 5077 0 TRP 549 20.850 168.241 16.967 1.00 33.48 c
ATOM 5078 N GLU 550 18.819 i6g.og8 17.438 1.00 33.48 c
ATOM 507g CA GLU 550 18.795 170.004 16.294 1.00 33.48 c
ATOM 5080 CB GLU 550 17.640 171.001 16.419 1.00 33.48 c
ATOM 5081 CG GLU 550 16.256 170.404 16.525 1.00 33.48 c
ATOM 5082 CD GLU 550 15.186 171.336 15.96g 1.00 33.48 c
ATOM 5083 OEl GLU 550 15.219 171.595 14.744 1.00 33.48 c
ATOM 5084 OE2 GLU 550 14.321 171.810 16.747 1.00 33.48 c
ATOM 5085 C GLU 550 20.086 170.806 16.126 1.00 33.48 c
ATOM 5086 0 GLU 550 20.678 170.846 15.04g 1.00 33.48 c
ATOM 5087 N VAL 551 20.513 171.459 17.197 1.00 33.48 c
ATOM 5088 CA VAL 551 2i.6gg 172.2 o 17.146 1.00 33.48 c
ATOM 508g CB VAL 551 21.g23 172.982 18.49g 1.00 33.48 c
ATOM sogo CGl VAL 551 23.179 173.825 18.456 1.00 33.48 c
ATOM sogi CG2 VAL 551 20.736 173.851 18.827 1.00 33.48 c
ATOM 5092 C VAL 551 22.953 171.535 16.745 1.00 33.48 c
ATOM 5093 0 VAL 551 23.632 171. goo 15.787 1.00 33.48 c
ATOM 50g4 N PHE 552 23.262 170.476 17.484 1.00 33.48 c
ATOM sogs CA PHE 552 24.450 16g.688 17.196 1.00 33.48 c
ATOM 50g6 CB PHE 552 24.709 168.670 18.311 1.00 33.48 c
ATOM 5097 CG PHE 552 25.490 16g.238 ig.460 1.00 33.48 c
ATOM 5098 CDl PHE 552 26.804 169.645 19.281 1.00 33.48 c ATOM sogg CD2 PHE 552 24.89g 16g.426 20.708 1.00 33.48 c
ATOM 5100 CEl PHE 552 27.516 170.235 20.324 1.00 33.48 c
ATOM 5101 CE2 PHE 552 25.616 170.020 21.759 1.00 33.48 c
ATOM 5102 CZ PHE 552 26.g22 170.424 21.560 1.00 33.48 c
ATOM 5103 C PHE 552 24.361 169.008 15.847 1.00 33.48 c
ATOM 5104 O PHE 552 25.350 168.950 15.120 1.00 33.48 c
ATOM 5105 N SER 553 23.185 168.515 15.488 1.00 33.48 c
ATOM 5106 CA SER 553 23.061 167.871 14.201 1.00 33.48 c
ATOM 5107 CB SER 553 22.004 166.778 14.26g 1.00 33.48 c
ATOM 5108 OG SER 553 20.77g 167.322 14.676 1.00 33.48 c
ATOM 5109 C SER 553 22.771 168.851 13.05g 1.00 33.48 c
ATOM 5110 O SER 553 22.027 168.53g 12.133 1.00 33.48 c
ATOM 5111 N GLU 554 23.373 170.035 13.146 1.00 33.48 c
ATOM 5112 CA GLU 554 23.262 171.086 12.129 1.00 33.48 c
ATOM 5113 CB GLU 554 24.153 170.727 10.g40 1.00 33.48 c
ATOM 5114 CG GLU 554 25.533 170.195 11.304 1.00 33.48 c
ATOM 5115 CD GLU 554 26.4g3 171.280 11.734 1.00 33.48 c
ATOM 5116 OEl GLU 554 26.133 172.031 12.656 1.00 33.48 c
ATOM 5117 OE2 GLU 554 27.603 171.377 11.157 1.00 33.48 c
ATOM 5118 C GLU 554 21.855 171.405 11.600 1.00 33.48 c
ATOM 5119 O GLU 554 21.663 171.596 10.400 1.00 33.48 c
ATOM 5120 N GLY 555 20.877 171.477 12.48g 1.00 33.48 c
ATOM 5121 CA GLY 555 19.529 171.770 12.048 1.00 33.48 c
ATOM 5122 C GLY 555 18.g25 170.652 11.217 1.00 33.48 c
ATOM 5123 O GLY 555 18.321 170.883 10.181 1.00 33.48 c
ATOM 5124 N LYS 556 ιg.og3169.421 11.670 1.00 33.48 c
ATOM 5125 CA LYS 556 18.545 168.283 10.g58 1.00 33.48 c
ATOM 5126 CB LYS 556 ig.370 167.025 11.250 1.00 33.48 c
ATOM 5127 CG LYS 556 ig.255 165. g20 10.205 1.00 33.48 c
ATOM 5128 CD LYS 556 ig.992 166.306 8.925 1.00 33.48 c
ATOM 5129 CE LYS 556 20.428 165.080 8.102 1.00 33.48 c
ATOM 5130 NZ LYS 556 ig.303 164.219 7.569 1.00 33.48 c
ATOM 5131 C LYS 556 17.144 168.119 11.513 1.00 33.48 c
ATOM 5132 0 LYS 556 16.86g 168.576 12.617 1.00 33.48 c
ATOM 5133 N ILE 557 16.268 167.470 10.751 1.00 33.48 c
ATOM 5134 CA ILE 557 14.8g5 167.251 11.183 1.00 33.48 c
ATOM 5135 CB ILE 557 13.941 167.058 9.gg2 1.00 33.48 c
ATOM 5136 CG2 ILE 557 12.510 167.010 10.4g4 1.00 33.48 c
ATOM 5137 CGl ILE 557 14.058 168.216 g.oii 1.00 33.48 c
ATOM 5138 CDl ILE 557 13.048 168.138 7.874 1.00 33.48 c
ATOM 5139 C ILE 557 14.748 166.018 12.067 1.00 33.48 c
ATOM 5140 0 ILE 557 15.065 164.908 11.656 1.00 33.48 c
ATOM 5141 N PRO 558 14.270 166. ιg7 13.297 1.00 33.48 c
ATOM 5142 CD PRO 558 14.092 167.465 14.014 1.00 33.48 c ATOM 5143 CA PRO 558 14.090 165.063 14.199 1.00 33.48 c
ATOM 5144 CB PRO 558 13.657 165.734 15.497 1.00 33 .48 c
ATOM 5145 CG PRO 558 14.344 167.061 15.430 1.00 33 .48 c
ATOM 5146 C PRO 558 13.016 164.116 13.653 1.00 33 .48 c
ATOM 5147 O PRO 558 12.003 164.559 13.122 1.00 33 .48 c
ATOM 5148 N TYR 559 13.256 162.813 13.783 1.00 33 .48 c
ATOM 5149 CA TYR 559 12.325 161.784 13.317 1.00 33 .48 c
ATOM 5150 CB TYR 559 11.043 161.827 14.165 1.00 33 .48 c
ATOM 5151 CG TYR 559 11.351 161.863 15.641 1.00 33 .48 c
ATOM 5152 CDl TYR 559 11.402 163.072 16.328 1.00 33 .48 c
ATOM 5153 CEl TYR 559 11.796 163.133 17.659 1.00 33 .48 c
ATOM 5154 CD2 TYR 559 11.691 160.705 16.329 1.00 33 .48 c
ATOM 5155 CE2 TYR 559 12.085 160.758 17.665 1.00 33 .48 c
ATOM 5156 CZ TYR 559 12.140 161.980 18.317 1.00 33, .48 c
ATOM 5157 OH TYR 559 12.585 162.052 19.612 1.00 33, .48 c
ATOM 5158 C TYR 559 11.987 161.929 11.830 1.00 33 .48 c
ATOM 5159 O TYR 559 10.9g2 161.372 11.346 1.00 33 .48 c
ATOM 5160 N GLU 560 12.838 162.670 11.119 1.00 33 .48 c
ATOM 5161 CA GLU 560 12.681 162. g43 9.686 1.00 33, .48 c
ATOM 5162 CB GLU 560 14.053 163.103 9.02g 1.00 33, .48 c
ATOM 5163 CG GLU 560 14.043 163. g22 7.748 1.00 33, .48 c
ATOM 5164 CD GLU 560 15.451 164.186 7.254 1.00 33, .48 c
ATOM 5165 OEl GLU 560 16.304 164.504 8.118 1.00 33, .48 c
ATOM 5166 OE2 GLU 560 15.712 164.083 6.026 1.00 33 .48 c
ATOM 5167 C GLU 560 11.918 161.819 9.012 1.00 33 .48 c
ATOM 5168 O GLU 560 11.004 162.042 8.211 1.00 33 .48 c
ATOM 5169 N ASN 561 12.296 160.605 g.364 1.00 33, .48 c
ATOM 5170 CA ASN 561 11.647 159.435 8.828 1.00 33, .48 c
ATOM 5171 CB ASN 561 12.533 158.232 9.097 1.00 33, .48 c
ATOM 5172 CG ASN 561 13.932 158.448 8.601 1.00 33, .48 c
ATOM 5173 ODl ASN 561 14.814 157.622 8.817 1.00 33, .48 c
ATOM 5174 ND2 ASN 561 14.150 159.574 7.924 1.00 33, .48 c
ATOM 5175 C ASN 561 10.272 15g.248 g.473 1.00 33, .48 c
ATOM 5176 0 ASN 561 9.243 15g.637 δ.δgg 1.00 33, .48 c
ATOM 5177 N ARG 562 10.282 158.657 10.668 1.00 33, .48 c
ATOM 5178 CA ARG 562 9.082 158.374 11.451 1.00 33, .48 c
ATOM 5179 CB ARG 562 g.447 158.378 12.g33 1.00 33, .48 c
ATOM 5180 CG ARG 562 10.719 157.588 13.258 1.00 33, .48 c
ATOM 5181 CD ARG 562 10.598 156.129 12.826 1.00 33, .48 c
ATOM 5182 NE ARG 562 11.494 155.237 13.575 1.00 33, .48 c
ATOM 5183 CZ ARG 562 11.120 154.040 14.033 1.00 33, .48 c
ATOM 5184 NHl ARG 562 9.877 153.623 13.810 1.00 33, .48 c
ATOM 5185 NH2 ARG 562 11.969 153.264 14.708 1.00 33, .48 c
ATOM 5186 C ARG 562 7.896 15g.322 11.213 1.00 33. ,48 c ATOM 5187 0 ARG 562 8.075 160.49 10.8g2 1.00 33.48 C
ATOM 5188 N SER 563 6.684 158.795 11.374 1.00 33.48 C
ATOM 518g CA SER 563 5.463 159.577 11.186 1.00 33.48 C
ATOM sigo CB SER 563 4.366 158.736 10.552 1.00 33.48 C
ATOM 5191 OG SER 563 3.728 157.961 11.556 1.00 33.48 C
ATOM 5192 C SER 563 4.944 160.052 12.535 1.00 33.48 C
ATOM 5193 0 SER 563 5.308 159.507 13.581 1.00 33.48 C
ATOM 5ig4 N ASN 564 4.068 161.052 12.4g5 1.00 33.48 C
ATOM 5ig5 CA ASN 564 3.485 161.619 13.703 1.00 33.48 C
ATOM 5igε CB ASN 564 2.221 162.404 13.345 1.00 33.48 C
ATOM 5i 7 CG ASN 564 1.838 163.410 14.414 1.00 33.48 C
ATOM 5198 ODl ASN 564 2.568 164.387 14.655 1.00 33.48 C
ATOM 519g ND2 ASN 564 0.688 163.181 15.068 1.00 33.48 C
ATOM 5200 C ASN 564 3.146 160.463 14.637 1.00 33.48 C
ATOM 5201 0 ASN 564 3.694 160.349 15.740 1.00 33.48 C
ATOM 5202 N SER 565 2.261 159.589 14.170 1.00 33.48 C
ATOM 5203 CA SER 565 1.857 158.423 14.g50 1.00 33.48 C
ATOM 5204 CB SER 565 0.747 157.662 14.234 1.00 33.48 C
ATOM 5205 OG SER 565 0.331 156.557 15.020 1.00 33.48 C
ATOM 5206 C SER 565 3.041 157.487 15.181 1.00 33.48 C
ATOM 5207 0 SER 565 3.238 156. gg3 16.291 1.00 33.48 C
ATOM 5208 N GLU 566 3.820 157.245 14.129 1.00 33.48 C
ATOM 5209 CA GLU 566 4.989 156.38g 14.230 1.00 33.48 c
ATOM 5210 CB GLU 566 5.830 156.47g 12.970 1.00 33.48 c
ATOM 5211 CG GLU 566 5.192 155.867 11.764 1.00 33.48 c
ATOM 5212 CD GLU 566 5.g36 156.195 10.488 1.00 33.48 c
ATOM 5213 OEl GLU 566 5.327 156.045 9.401 1.00 33.48 c
ATOM 5214 OE2 GLU 566 7.124 156.595 10.569 1.00 33.48 c
ATOM 5215 C GLU 566 5.860 156.793 15.398 1.00 33.48 c
ATOM 5216 0 GLU 566 6.263 155.951 16.207 1.00 33.48 c
ATOM 5217 N VAL 567 6.155 158.087 15.483 1.00 33.48 c
ATOM 5218 CA VAL 567 7.010 158.601 16.549 1.00 33.48 c
ATOM 5219 CB VAL 567 7.190 160.122 16.452 1.00 33.48 c
ATOM 5220 CGl VAL 567 8.110 160.592 17.561 1.00 33.48 c
ATOM 5221 CG2 VAL 567 7.773 160.495 15.091 1.00 33.48 c
ATOM 5222 C VAL 567 6.441 158.272 17.915 1.00 33.48 c
ATOM 5223 0 VAL 567 7.186 157.924 18.843 1.00 33.48 c
ATOM 5224 N VAL 568 5.120 158.3g4 18.032 1.00 33.48 c
ATOM 5225 CA VAL 568 4.440 158. ogo 19.281 1.00 33.48 c
ATOM 5226 CB VAL 568 2.915 158.202 19.130 1.00 33.48 c
ATOM 5227 CGl VAL 568 2.253 158.065 20.491 1.00 33.48 c
ATOM 5228 CG2 VAL 568 2.543 15g.525 18.477 1.00 33.48 c
ATOM 5229 C VAL 568 4.771 156.650 19.656 1.00 33.48 c
ATOM 5230 0 VAL 568 5.078 156.342 20.805 1.00 33.48 c ATOM 5231 N GLU 56 4.713 155.769 18.667 1.00 33.48 C
ATOM 5232 CA GLU 56 4. ggg 154.360 18.8g6 1.00 33.48 C
ATOM 5233 CB GLU 569 4.715 153.550 17.626 1.00 33.48 C
ATOM 5234 CG GLU 569 4.816 152.043 17.820 1.00 33.48 C
ATOM 5235 CD GLU 56g 3.938 151.531 18. g60 1.00 33.48 C
ATOM 5236 OEl GLU 56g 4.013 150.313 ig.272 1.00 33.48 C
ATOM 5237 OE2 GLU 56g 3.171 152.342 ig.542 1.00 33.48 C
ATOM 5238 C GLU 56 6.441 154.142 ig.346 1.00 33.48 C
ATOM 523g O GLU 56g 6.686 153.594 20.428 1.00 33.48 C
ATOM 5240 N ASP 570 7.387 154.584 18.518 1.00 33.48 C
ATOM 5241 CA ASP 570 8.810 154.444 18.811 1.00 33.48 C
ATOM 5242 CB ASP 570 9.627 155.252 17.808 1.00 33.48 c
ATOM 5243 CG ASP 570 g.284 154.916 16.365 1.00 33.48 c
ATOM 5244 ODl ASP 570 g.6g3 155.677 15.464 1.00 33.48 c
ATOM 5245 OD2 ASP 570 8.607 153.891 16.127 1.00 33.48 c
ATOM 5246 C ASP 570 9.149 154.913 20.218 1.00 33.48 c
ATOM 5247 O ASP 570 9.616 154.130 21.037 1.00 33.48 c
ATOM 5248 N ILE 571 8.906 156.201 20.478 1.00 33.48 c
ATOM 524g CA ILE 571 9.174 156.854 21.774 1.00 33.48 c
ATOM 5250 CB ILE 571 8.568 158.286 21.818 1.00 33.48 c
ATOM 5251 CG2 ILE 571 8.800 158.916 23.180 1.00 33.48 c
ATOM 5252 CGl ILE 571 9.198 159.155 20.732 1.00 33.48 c
ATOM 5253 CDl ILE 571 8.529 160.465 20.583 1.00 33.48 c
ATOM 5254 C ILE 571 8.587 156.078 22.g34 1.00 33.48 c
ATOM 5255 O ILE 571 9.202 155. g2 23.991 1.00 33.48 c
ATOM 5256 N SER 572 7.370 155.606 22.722 1.00 33.48 c
ATOM 5257 CA SER 572 6.676 154.828 23.726 1.00 33.48 c
ATOM 5258 CB SER 572 5.217 154.620 23.295 1.00 33.48 c
ATOM 5259 OG SER 572 4.559 155.874 23.110 1.00 33.48 c
ATOM 5260 C SER 572 7.401 153.491 23.918 1.00 33.48 c
ATOM 5261 O SER 572 7.566 153.041 25.052 1.00 33.48 c
ATOM 5262 N THR 573 7.848 152.877 22.816 1.00 33.48 c
ATOM 5263 CA THR 573 8.570 151.600 22.869 1.00 33.48 c
ATOM 5264 CB THR 573 8.770 150.97g 21.472 1.00 33.48 c
ATOM 5265 OGl THR 573 9.587 151.852 20.676 1.00 33.48 c
ATOM 5266 CG2 THR 573 7.437 150.746 20.775 1.00 33.48 c
ATOM 5267 C THR 573 9.971 151.747 23.46g 1.00 33.48 c
ATOM 5268 O THR 573 10.653 150.74g 23.686 1.00 33.48 c
ATOM 5269 N GLY 574 10.413 152. g84 23.6g2 1.00 33.48 c
ATOM 5270 CA GLY 574 11.724 153.214 24.282 1.00 33.48 c
ATOM 5271 C GLY 574 12.800 153.828 23.3g8 1.00 33.48 c
ATOM 5272 O GLY 574 13.902 154.148 23.866 1.00 33.48 c
ATOM 5273 N PHE 575 12.482 153. ggg 22.123 1.00 33.48 c
ATOM 5274 CA PHE 575 13.423 154.55g 21.165 1.00 33.48 c ATOM 5275 CB PHE 575 12.87g 154.357 ig.763 1.00 33..48 c
ATOM 5276 CG PHE 575 12.728 152.930 ιg.38 1.00 33. ,48 c
ATOM 5277 CDl PHE 575 11.843 152.547 18.408 1.00 33. ,48 c
ATOM 5278 CD2 PHE 575 13.478 151.959 20.053 1.00 33, ,48 c
ATOM 527 CEl PHE 575 11.702 151.204 18.075 1.00 33, .48 c
ATOM 5280 CE2 PHE 575 13.353 150.625 ig.735 1.00 33, .48 c
ATOM 5281 CZ PHE 575 12.465 150.236 18.747 1.00 33 .48 c
ATOM 5282 C PHE 575 13.761 156.027 21.370 1.00 33, .48 c
ATOM 5283 0 PHE 575 13.017 156.767 22.015 1.00 33 .48 c
ATOM 5284 N ARG 576 14.884 156.445 20.7g5 1.00 33, .48 c
ATOM 5285 CA ARG 576 15.332 157.814 20.923 1.00 33, .48 c
ATOM 5286 CB ARG 576 16.146 157. g35 22.207 1.00 33 .48 c
ATOM 5287 CG ARG 576 15.374 157.568 23.452 1.00 33, .48 c
ATOM 5288 CD ARG 576 14.238 158.537 23.683 1.00 33 .48 c
ATOM 528g NE ARG 576 13.519 158.228 24.909 1.00 33 .48 c
ATOM 52go CZ ARG 576 12.325 157.646 24.956 1.00 33, .48 c
ATOM 52gi NHl ARG 576 11.702 157.313 23.836 1.00 33, .48 c
ATOM 52 2 NH2 ARG 576 11.763 157.377 26.12g 1.00 33, .48 c
ATOM 52g3 C ARG 576 16.145 158.304 ig.708 1.00 33, .48 c
ATOM 52g4 0 ARG 576 16.555 157.517 18.860 1.00 33, .48 c
ATOM 52g5 N LEU 577 16.367 159.613 ig.624 1.00 33, .48 c
ATOM 52g6 CA LEU 577 17.115 160.190 18.518 1.00 33, .48 c
ATOM 52g7 CB LEU 577 17.0g6 161.719 18.588 1.00 33 .48 c
ATOM 52g8 CG LEU 577 15.758 162.445 18.428 1.00 33, .48 c
ATOM 52gg CDl LEU 577 15.g40 163.917 18.770 1.00 33 .48 c
ATOM 5300 CD2 LEU 577 15.238 162.272 17.004 1.00 33, .48 c
ATOM 5301 C LEU 577 18.53g 159.6 7 18.613 1.00 33, .48 c
ATOM 5302 0 LEU 577 ιg.og2159.601 ig.705 1.00 33 .48 c
ATOM 5303 N TYR 578 19.125 159.3g8 17.456 1.00 33, .48 c
ATOM 5304 CA TYR 578 20.486 158.8g3 17.381 1.00 33 .48 c
ATOM 5305 CB TYR 578 20.737 158.283 16.002 1.00 33 .48 c
ATOM 5306 CG TYR 578 19.944 157.011 15.759 1.00 33, .48 c
ATOM 5307 CDl TYR 578 18.770 157.026 15.006 1.00 33 .48 c
ATOM 5308 CEl TYR 578 18.019 155.866 14.818 1.00 33, .48 c
ATOM 530g CD2 TYR 578 20.346 155.7g7 16.318 1.00 33, .48 c
ATOM 5310 CE2 TYR 578 19.599 154.635 16.139 1.00 33 .48 c
ATOM 5311 CZ TYR 578 18.439 154.680 15.392 1.00 33, .48 c
ATOM 5312 OH TYR 578 17.666 153.548 15.256 1.00 33, .48 c
ATOM 5313 C TYR 578 21.54015g.g40 17.685 1.00 33 .48 c
ATOM 5314 0 TYR 578 21.324 161.122 17.487 1.00 33, .48 c
ATOM 5315 N LYS 57g 22.689 159.489 18.172 1.00 33, .48 c
ATOM 5316 CA LYS 579 23.777 160.394 18.503 1.00 33, .48 c
ATOM 5317 CB LYS 579 24.929 15g.646 19.170 1.00 33, .48 c
ATOM 5318 CG LYS 57g 26.133 160.533 19.484 1.00 33, .48 c ATOM 53ig CD LYS 579 27.431 15g.823 19.156 1.00 33.,48 c
ATOM 5320 CE LYS 579 28.634 160.732 19.287 1.00 33. .48 c
ATOM 5321 NZ LYS 579 28.963 160. g77 20.704 1.00 33, .48 c
ATOM 5322 C LYS 579 24.321 161.108 17.281 1.00 33, .48 c
ATOM 5323 O LYS 579 24.740 160.477 16.313 1.00 33, .48 c
ATOM 5324 N PRO 580 24.300 162.446 17.300 1.00 33, .48 c
ATOM 5325 CD PRO 580 23.505 163.340 18.164 1.00 33, .48 c
ATOM 5326 CA PRO 580 24.823 163.172 16.151 1.00 33, .48 c
ATOM 5327 CB PRO 580 24.166 164.544 16.289 1.00 33, .48 c
ATOM 5328 CG PRO 580 23.984 164.6g2 17.747 1.00 33, .48 c
ATOM 532g C PRO 580 26.335 163.209 16.229 1.00 33, .48 c
ATOM 5330 O PRO 580 26.901 163.279 17.309 1.00 33, .48 c
ATOM 5331 N ARG 581 26.978 163.153 15.069 1.00 33, .48 c
ATOM 5332 CA ARG 581 28.435 163.165 14.g62 1.00 33, .48 c
ATOM 5333 CB ARG 581 28.847 163.345 13.504 1.00 33, .48 c
ATOM 5334 CG ARG 581 30.295 163.011 13.201 1.00 33, .48 c
ATOM 5335 CD ARG 581 31.242 164.195 13.345 1.00 33 .48 c
ATOM 5336 NE ARG 581 32.622 163.795 13.040 1.00 33 .48 c
ATOM 5337 CZ ARG 581 33.675 164.620 12. gg4 1.00 33 .48 c
ATOM 5338 NHl ARG 581 33.535 165.928 13.234 1.00 33, .48 c
ATOM 533g NH2 ARG 581 34.882 164.134 12.705 1.00 33, .48 c
ATOM 5340 C ARG 581 29.120 164.225 15.809 1.00 33 .48 c
ATOM 5341 O ARG 581 29.g68 163.893 16.621 1.00 33 .48 c
ATOM 5342 N LEU 582 28.753 165.493 15.642 1.00 33 .48 c
ATOM 5343 CA LEU 582 2g.404 166.561 16.403 1.00 33 .48 c
ATOM 5344 CB LEU 582 2g.l87 167.919 15.724 1.00 33 .48 c
ATOM 5345 CG LEU 582 2g.724 168.098 14.29g 1.00 33 .48 c
ATOM 5346 CDl LEU 582 2g.387 169.475 13.817 1.00 33 .48 c
ATOM 5347 CD2 LEU 582 31.215 167.885 14.255 1.00 33 .48 c
ATOM 5348 C LEU 582 2g.007 166.652 17.873 1.00 33 .48 c
ATOM 534g O LEU 582 2g.4gδ 167.515 18.602 1.00 33 .48 c
ATOM 5350 N ALA 583 28.13g 165.753 18.319 1.00 33 .48 c
ATOM 5351 CA ALA 583 27.721 165.75g 19.713 1.00 33 .48 c
ATOM 5352 CB ALA 583 26.28g 165.316 19.825 1.00 33 .48 c
ATOM 5353 C ALA 583 28.598 164.818 20.498 1.00 33 .48 c
ATOM 5354 O ALA 583 28.670 163.649 20.178 1.00 33 .48 c
ATOM 5355 N SER 584 29.275 165.312 21.520 1.00 33 .48 c
ATOM 5356 CA SER 584 30.119 164.434 22.311 1.00 33 .48 c
ATOM 5357 CB SER 584 30.868 165.221 23.382 1.00 33 .48 c
ATOM 5358 OG SER 584 29.g80 165.734 24.364 1.00 33 .48 c
ATOM 535g C SER 584 2g.261 163.384 22.9g2 1.00 33 .48 c
ATOM 5360 O SER 584 28.053 163.560 23.16g 1.00 33 .48 c
ATOM 5361 N THR 585 2g.8g3 162.285 23.37g 1.00 33 .48 c
ATOM 5362 CA THR 585 2g.201 161.200 24.071 1.00 33 .48 c ATOM 5363 CB THR 585 30.207 160.160 24.536 1.00 33.48 C
ATOM 5364 OGl THR 585 31.3gθ 160.828 25.004 1.00 33.48 C
ATOM 5365 CG2 THR 585 30.547 15g.232 23.399 1.00 33.48 C
ATOM 5366 C THR 585 28.468 161.762 25.289 1.00 33.48 C
ATOM 5367 O THR 585 27.2g5 161.453 25.534 1.00 33.48 C
ATOM 5368 N HIS 586 2g.l85 162.586 26.048 1.00 33.48 C
ATOM 5369 CA HIS 586 28.643 163.232 27.232 1.00 33.48 C
ATOM 5370 CB HIS 586 2g.682 164.216 27.776 1.00 33 .48 C
ATOM 5371 CG HIS 586 2g.346 164.78g 29.116 1.00 33.48 C
ATOM 5372 CD2 HIS 586 30.019 165.663 29.g02 1.00 33 .48 C
ATOM 5373 NDl HIS 586 28.205 164.452 2g.810 1.00 33.48 C
ATOM 5374 CEl HIS 586 28.190 165. og2 30.g67 1.00 33.48 C
ATOM 5375 NE2 HIS 586 2g.27g 165.834 31.047 1.00 33 .48 C
ATOM 5376 C HIS 586 27.356 163. g72 26.840 1.00 33 .48 C
ATOM 5377 0 HIS 586 26.300 163.787 27.45g 1.00 33.48 C
ATOM 5378 N VAL 587 27.450 164.7 6 25.7g7 1.00 33.48 C
ATOM 5379 CA VAL 587 26.304165.568 25.337 1.00 33.48 C
ATOM 5380 CB VAL 587 26.634166.382 24.074 1.00 33.48 C
ATOM 5381 CGl VAL 587 25.356 166. gg2 23.508 1.00 33.48 c
ATOM 5382 CG2 VAL 587 27.647 167.461 24.401 1.00 33.48 c
ATOM 5383 C VAL 587 25.ogι 164.698 25.036 1.00 33.48 c
ATOM 5384 0 VAL 587 23.947 165.161 25.131 1.00 33.48 c
ATOM 5385 N TYR 588 25.337 163.444 24.668 1.00 33.48 c
ATOM 5386 CA TYR 588 24.242 162.537 24.35g 1.00 33.48 c
ATOM 5387 CB TYR 588 24.737 161.420 23.452 1.00 33.48 c
ATOM 5388 CG TYR 588 23.637 160.616 22.786 1.00 33.48 c
ATOM 5389 CDl TYR 588 22.683 161.234 21.983 1.00 33 .48 c
ATOM 5390 CEl TYR 588 21.711160.494 21.346 1.00 33.48 c
ATOM 53gi CD2 TYR 588 23.578 159.22g 22.934 1.00 33.48 c
ATOM 53g2 CE2 TYR 588 22.604 158.489 22.304 1.00 33.48 c
ATOM 5393 CZ TYR 588 21.680 159.127 21.514 1.00 33.48 c
ATOM 5394 OH TYR 588 20.717 158.391 20.898 1.00 33 .48 c
ATOM 5395 C TYR 588 23.659 161.958 25.646 1.00 33.48 c
ATOM 5396 0 TYR 588 22.466 161.639 25.714 1.00 33.48 c
ATOM 5397 N GLN 58g 24.507 161.819 26.666 1.00 33 .48 c
ATOM 5398 CA GLN 58g 24.060161.304 27.95g 1.00 33.48 c
ATOM 53gg CB GLN 58 25.243 161.138 28.g24 1.00 33.48 c
ATOM 5400 CG GLN 58g 26.209 160.011 28.538 1.00 33 .48 c
ATOM 5401 CD GLN 58 27.284 159.737 2g.602 1.00 33.48 c
ATOM 5402 OEl GLN 58g 28.260 160.491 2g.743 1.00 33.48 c
ATOM 5403 NE2 GLN 58g 27.101158.656 30.358 1.00 33.48 c
ATOM 5404 C GLN 589 23.072 162.324 28.510 1.00 33.48 c
ATOM 5405 0 GLN 589 22.122 161.984 2g.217 1.00 33.48 c
ATOM 5406 N ILE 590 23.2g6163.587 28.16g 1.00 33.48 c ATOM 5407 CA ILE sgo 22.40g 164.645 28.615 1.00 33 .48 C
ATOM 5408 CB ILE sgo 23.084 166.000 28.516 1.00 33 .48 C
ATOM 540g CG2 ILE s o 22.146 167.063 2g.023 1.00 33 .48 C
ATOM 5410 CGl ILE sgo 24.372 165.991 2g.335 1.00 33 .48 C
ATOM 5411 CDl ILE sgo 25.2ig 167.217 2g.l43 1.00 33 .48 C
ATOM 5412 C ILE sgo 21.165 164.641 27.736 1.00 33 .48 C
ATOM 5413 O ILE sgo 20.050 164.507 28.241 1.00 33 .48 C
ATOM 5414 N MET 591 21.351164.780 26.424 1.00 33 .48 C
ATOM 5415 CA MET 591 20.217 164.775 25.4g6 1.00 33 .48 C
ATOM 5416 CB MET 591 20.6g7 164.578 24.064 1.00 33.48 C
ATOM 5417 CG MET 591 21.588 165.665 23.553 1.00 33 .48 C
ATOM 5418 SD MET 591 22.161165.301 21.912 1.00 33 .48 C
ATOM 54ig CE MET 591 20.682 164. εgo 21.190 1.00 33.48 C
ATOM 5420 C MET 591 ιg.26g 163.631 25.843 1.00 33 .48 C
ATOM 5421 O MET 591 18.04g 163.702 25.640 1.00 33 .48 c
ATOM 5422 N ASN 592 ig.857 162.568 26.374 1.00 33.48 c
ATOM 5423 CA ASN 592 19.103 161.394 26.740 1.00 33 .48 c
ATOM 5424 CB ASN 5g2 20.022 160.175 26.715 1.00 33 .48 c
ATOM 5425 CG ASN 5g2 19.857 159.374 25.457 1.00 33 .48 c
ATOM 5426 ODl ASN 5g2 18.858 158.667 25.288 1.00 33 .48 c
ATOM 5427 ND2 ASN 5g2 20.817 159.4g5 24.549 1.00 33 .48 c
ATOM 5428 C ASN 592 18.403 161.511 28.081 1.00 33 .48 c
ATOM 542g O ASN 592 17.256 161.072 28.233 1.00 33 .48 c
ATOM 5430 N HIS 593 19.084 162.082 29.065 1.00 33 .48 c
ATOM 5431 CA HIS 593 18.434 162.215 30.350 1.00 33 .48 c
ATOM 5432 CB HIS 593 19.334162. g36 31.355 1.00 33.48 c
ATOM 5433 CG HIS 593 18.872 162.800 32.774 1.00 33 .48 c
ATOM 5434 CD2 HIS 5 3 17.804162.157 33.304 1.00 33 .48 c
ATOM 5435 NDl HIS 593 19.555 163.350 33.839 1.00 33.48 c
ATOM 5436 CEl HIS 593 18.927 163.04g 34.963 1.00 33 .48 c
ATOM 5437 NE2 HIS 5g3 17.862 162.326 34.665 1.00 33 .48 c
ATOM 5438 C HIS 5 3 17.182 163.034 30.045 1.00 33.48 c
ATOM 543g O HIS 5 3 16.057 162.604 30.319 1.00 33 .48 c
ATOM 5440 N CYS 5g4 17.389 164.189 2g.421 1.00 33 .48 c
ATOM 5441 CA CYS 594 16.297 165.071 29.050 1.00 33 .48 c
ATOM 5442 CB CYS 594 16.749 166.064 27.963 1.00 33 .48 c
ATOM 5443 SG CYS 594 17.854 167.418 28.514 1.00 33 .48 c
ATOM 5444 C CYS 594 15.101164.274 28.547 1.00 33 .48 c
ATOM 5445 O CYS 594 13.g62 164.707 28.6g7 1.00 33 .48 c
ATOM 5446 N TRP 595 15.335 163.104 27.g61 1.00 33 .48 c
ATOM 5447 CA TRP 595 14.201162.342 27.458 1.00 33 .48 c
ATOM 5448 CB TRP 595 14.477 161.803 26.048 1.00 33.48 c
ATOM 544g CG TRP 595 14.g22 162.85g 25.062 1.00 33 .48 c
ATOM 5450 CD2 TRP 595 15.8g5 162.702 24.0ig 1.00 33 .48 c ATOM 5451 CE2 TRP 595 15.g65 163. g33 23.318 1.00 33.48 C
ATOM 5452 CE3 TRP 595 16.712 161.63g 23.605 1.00 33.48 C
ATOM 5453 CDl TRP 595 14.453 164.150 24.g54 1.00 33.48 C
ATOM 5454 NEl TRP 595 15.07g 164.7g7 23.g07 1.00 33.48 C
ATOM 5455 CZ2 TRP 595 16.8ig 164.127 22.231 1.00 33.48 C
ATOM 5456 CZ3 TRP 595 17.560 161.831 22.523 1.00 33.48 C
ATOM 5457 CH2 TRP 595 17.607 163.06g 21.848 1.00 33.48 C
ATOM 5458 C TRP 595 13.714 161.203 28.341 1.00 33 .48 C
ATOM 545g O TRP 595 13.166 160.224 27.825 1.00 33.48 C
ATOM 5460 N LYS 596 13.8g8 161.315 2g.656 1.00 33.48 C
ATOM 5461 CA LYS 596 13.404 160.270 30.556 1.00 33.48 C
ATOM 5462 CB LYS 596 13.767 160.583 32.017 1.00 33.48 C
ATOM 5463 CG LYS 596 15.226 160.326 32.345 1.00 33.48 C
ATOM 5464 CD LYS 596 15.5g8 158.8g2 31.958 1.00 33.48 C
ATOM 5465 CE LYS 596 17.103 158.675 31.890 1.00 33.48 C
ATOM 5466 NZ LYS 596 17.750 158.623 33.232 1.00 33.48 C
ATOM 5467 C LYS 596 11.882 160.185 30.405 1.00 33.48 C
ATOM 5468 O LYS 596 11.193 161.201 30.481 1.00 33.48 C
ATOM 546g N GLU 5g7 11.354 158. g86 30.171 1.00 33.48 C
ATOM 5470 CA GLU 5g7 9.g04 158.825 3o.oog 1.00 33.48 C
ATOM 5471 CB GLU 5g7 g.515 157.341 2g.g74 1.00 33.48 C
ATOM 5472 CG GLU 5 7 8.264 157.052 2g.l33 1.00 33.48 C
ATOM 5473 CD GLU 5g7 7.126 156.404 2g.g35 1.00 33.48 c
ATOM 5474 OEl GLU 5g7 7.410 155.432 30.6g5 1.00 33.48 c
ATOM 5475 OE2 GLU 5g7 5.956 156.858 2g.7gι 1.00 33.48 c
ATOM 5476 C GLU 5 7 9.206 lsg.sog 31.180 1.00 33.48 c
ATOM 5477 O GLU 5g7 8.100 160.045 31.036 1.00 33.48 c
ATOM 5478 N ARG 5 8 9.882 15g.488 32.330 1.00 33.48 c
ATOM 547g CA ARG 5gδ g.3gι 160. og2 33.567 1.00 33.48 c
ATOM 5480 CB ARG 598 g .844 15g.270 34.7g3 1.00 33.48 c
ATOM 5481 CG ARG 598 8. g87 158.065 35.229 1.00 33.48 c
ATOM 5482 CD ARG sgδ g .465 157.587 36.627 1.00 33.48 c
ATOM 5483 NE ARG 5gδ 8.623 156.545 37.215 1.00 33.48 c
ATOM 5484 CZ ARG sgδ 8. 723 155.234 36.954 1.00 33.48 c
ATOM 5485 NHl ARG sgδ g .651154.774 36.098 1.00 33.48 c
ATOM 5486 NH2 ARG sgδ 7.887 154.370 37.547 1.00 33.48 c
ATOM 5487 C ARG sgδ g . g26 161.521 33.749 1.00 33.48 c
ATOM 5488 O ARG 5g8 11.142 161.742 33.740 1.00 33.48 c
ATOM 548g N PRO 5g9 g.025 162.503 33.g31 1.00 33.48 c
ATOM 54go CD PRO 59g 7. 574 162.442 33.6g3 1.00 33.48 c
ATOM 54gi CA PRO 5g9 g.446 163.888 34.124 1.00 33.48 c
ATOM 5492 CB PRO 59g 8.130 164.611 34.317 1.00 33.48 c
ATOM 5493 CG PRO sgg 7.236 163.877 33.3g2 1.00 33.48 c
ATOM 54g4 C PRO sgg 10.335 163. 85 35.346 1.00 33.48 c ATOM 5495 0 PRO 59g 11.440 164.518 35.285 1.00 33.,48 C
ATOM 5496 N GLU 600 g.853 163.460 36.463 1.00 33. ,48 C
ATOM 5497 CA GLU 600 10.641 163.502 37.692 1.00 33. ,48 C
ATOM 5498 CB GLU 600 10.014 162.611 38.758 1.00 33. ,48 C
ATOM 549g CG GLU 600 9.611161.260 38.220 1.00 33. ,48 C
ATOM 5500 CD GLU 600 8.768 160.480 39.211 1.00 33. ,48 c
ATOM 5501 OEl GLU 600 8.133 159.474 38.791 1.00 33. ,48 c
ATOM 5502 OE2 GLU 600 8.742 160.86 40.409 1.00 33. ,48 c
ATOM 5503 C GLU 600 12.063 163.040 37.406 1.00 33, ,48 c
ATOM 5504 0 GLU 600 13.025 163.5g4 37.947 1.00 33, ,48 c
ATOM 5505 N ASP 601 12.197 162.036 36.542 1.00 33, .48 c
ATOM 5506 CA ASP 601 13.511161.514 36.208 1.00 33. .48 c
ATOM 5507 CB ASP 601 13.365 160.232 35.402 1.00 33. ,48 c
ATOM 5508 CG ASP 601 13.254 158. gg9 36.2g2 1.00 33. .48 c
ATOM 550g ODl ASP 601 14.275 158.618 36.gi3 1.00 33. .48 c
ATOM 5510 OD2 ASP 601 12.148 158.419 36.381 1.00 33, .48 c
ATOM 5511 C ASP 601 14.386 162.510 35.465 1.00 33, .48 c
ATOM 5512 0 ASP 601 15.602 162.524 35.640 1.00 33. .48 c
ATOM 5513 N ARG 602 13.761163.353 34.651 1.00 33, .48 c
ATOM 5514 CA ARG 602 14.474 164.367 33.878 1.00 33, .48 c
ATOM 5515 CB ARG 602 13.512 165.025 32.882 1.00 33, .48 c
ATOM 5516 CG ARG 602 12.695 164.008 32.082 1.00 33, .48 c
ATOM 5517 CD ARG 602 11.479 164.610 31.410 1.00 33, .48 c
ATOM 5518 NE ARG 602 10.495 163.582 31.073 1.00 33, .48 c
ATOM 55ig CZ ARG 602 9.251 163.833 30.663 1.00 33, .48 c
ATOM 5520 NHl ARG 602 8.838 165.091 30.533 1.00 33, .48 c
ATOM 5521 NH2 ARG 602 8.411162.830 30.3g5 1.00 33, .48 c
ATOM 5522 C ARG 602 15.063 165.424 34.7gg 1.00 33, .48 c
ATOM 5523 0 ARG 602 14.558 165.664 35.8gθ 1.00 33, .48 c
ATOM 5524 N PRO 603 16.156 166.063 34.375 1.00 33, .48 c
ATOM 5525 CD PRO 603 16.917 165.765 33.151 1.00 33, .48 c
ATOM 5526 CA PRO 603 16.818 167.108 35.161 1.00 33, .48 c
ATOM 5527 CB PRO 603 18.201167.16g 34.543 1.00 33, .48 c
ATOM 5528 CG PRO 603 17. gio 166.915 33.111 1.00 33 .48 c
ATOM 5529 C PRO 603 16.075 168.435 35.021 1.00 33 .48 c
ATOM 5530 0 PRO 603 15.122 168.539 34.245 1.00 33 .48 c
ATOM 5531 N ALA 604 16.500169.448 35.76g 1.00 33, .48 c
ATOM 5532 CA ALA 604 15.842 170.758 35.702 1.00 33 .48 c
ATOM 5533 CB ALA 604 15.616 171.327 37.101 1.00 33 .48 c
ATOM 5534 C ALA 604 16.725 171.687 34.g08 1.00 33 .48 c
ATOM 5535 0 ALA 604 17.g44 171.496 34.875 1.00 33 .48 c
ATOM 5536 N PHE 605 16.120 172.688 34.270 1.00 33 .48 c
ATOM 5537 CA PHE 605 16.902 173.625 33.474 1.00 33 .48 c
ATOM 5538 CB PHE 605 16.028 174.757 32.g36 1.00 33.48 c ATOM 5539 CG PHE 605 15.229 174.362 31.725 1.00 33.48 C
ATOM 5540 CDl PHE 605 15.854 174.166 30.505 1.00 33.48 C
ATOM 5541 CD2 PHE 605 13.855 174.127 31.821 1.00 33.48 C
ATOM 5542 CEl PHE 605 15.131173.741 2g.402 1.00 33.48 C
ATOM 5543 CE2 PHE 605 13.115 173.6g7 30.716 1.00 33.48 C
ATOM 5544 CZ PHE 605 13.753 173.503 2g.506 1.00 33.48 C
ATOM 5545 C PHE 605 18.028 174.140 34.325 1.00 33.48 C
ATOM 5546 O PHE 605 ig.108 174.446 33.826 1.00 33.48 C
ATOM 5547 N SER 606 17.786 174.199 35.625 1.00 33.48 C
ATOM 5548 CA SER 606 18.830 174.640 36.532 1.00 33.48 C
ATOM 5549 CB SER 606 18.337 174.551 37.g76 1.00 33.48 C
ATOM 5550 OG SER 606 i6.g5g 174.214 38.003 1.00 33.48 C
ATOM 5551 C SER 606 ιg.g84 173.661 36.304 1.00 33 .48 C
ATOM 5552 O SER 606 21.105 174.058 35.g67 1.00 33.48 C
ATOM 5553 N ARG 607 19.661172.377 36.464 1.00 33.48 c
ATOM 5554 CA ARG 607 20.58g 171.259 36.315 1.00 33.48 c
ATOM 5555 CB ARG 607 ig.802 169. 38 36.416 1.00 33 .48 c
ATOM 5556 CG ARG 607 20.5g4 168.649 36.105 1.00 33.48 c
ATOM 5557 CD ARG 607 21.646 168.330 37.167 1.00 33.48 c
ATOM 5558 NE ARG 607 21.065 168.138 38.503 1.00 33.48 c
ATOM 5559 CZ ARG 607 20.286 167.113 38.86g 1.00 33.48 c
ATOM 5560 NHl ARG 607 ιg.g70166.141 38.005 1.00 33.48 c
ATOM 5561 NH2 ARG 607 19.810 167.066 40.116 1.00 33.48 c
ATOM 5562 C ARG 607 21.379 171.291 35.006 1.00 33.48 c
ATOM 5563 O ARG 607 22.617 171.314 35.011 1.00 33 .48 c
ATOM 5564 N LEU 608 20.661 171.287 33.887 1.00 33 .48 c
ATOM 5565 CA LEU 608 21.312 171.288 32.58g 1.00 33 .48 c
ATOM 5566 CB LEU 608 20.267 171.370 31.475 1.00 33.48 c
ATOM 5567 CG LEU 608 19.304 170.185 31.367 1.00 33.48 c
ATOM 5568 CDl LEU 608 18.324 170.421 30.244 1.00 33.48 c
ATOM 556g CD2 LEU 608 20.082 168. go7 31.114 1.00 33.48 c
ATOM 5570 C LEU 608 22.324172.422 32.450 1.00 33.48 c
ATOM 5571 O LEU 608 23.421172.228 31.915 1.00 33.48 c
ATOM 5572 N LEU 60g 21.g70 173.603 32.946 1.00 33.48 c
ATOM 5573 CA LEU 6og 22.86g 174.741 32.837 1.00 33.48 c
ATOM 5574 CB LEU 6og 22.213 175.992 33.424 1.00 33.48 c
ATOM 5575 CG LEU 6og 23.088 177.252 33.368 1.00 33.48 c
ATOM 5576 CDl LEU 6og 23.807 177.345 32.026 1.00 33 .48 c
ATOM 5577 CD2 LEU 6og 22.226 178.483 33.615 1.00 33.48 c
ATOM 5578 C LEU 6og 24.248 174.479 33.482 1.00 33.48 c
ATOM 557g O LEU 6og 25.285 174.9og 32.951 1.00 33.48 c
ATOM 5580 N ARG 610 24.270 173.75g 34.602 1.00 33.48 c
ATOM 5581 CA ARG 610 25.533 173.458 35.266 1.00 33.48 c
ATOM 5582 CB ARG 610 25.285 172.833 36.627 1.00 33.48 c ATOM 5583 CG ARG 610 24.696 173.755 37.644 1.0033,.48 c
ATOM 5584 CD ARG 610 25.450 173.596 38.936 1.00 33, .48 c
ATOM 5585 NE ARG 610 24.798 174.337 39.gg4 1.00 33, .48 c
ATOM 5586 CZ ARG 610 23.684 173.937 40.5gθ 1.00 33, .48 c
ATOM 5587 NHl ARG 610 23.119 172.787 40.228 1.00 33, .48 c
ATOM 5588 NH2 ARG 610 23.116 174.705 41.522 1.00 33, .48 c
ATOM 5589 C ARG 610 26.361 172.491 34.441 1.00 33, .48 c
ATOM 5590 O ARG 610 27.516 172.758 34. iog 1.00 33, .48 c
ATOM 5591 N GLN 611 25.753 171.355 34.124 1.00 33, .48 c
ATOM 55g2 CA GLN 611 26.396 170.313 33.341 1.00 33, .48 c
ATOM 5593 CB GLN 611 25.372 169.222 33.043 1.00 33, .48 c
ATOM 5594 CG GLN 611 24.542 168.876 34.274 1.00 33, .48 c
ATOM 5595 CD GLN 611 23.519 167.780 34.040 1.00 33, .48 c
ATOM 5596 OEl GLN 611 22.662 167.886 33.154 1.00 33, .48 c
ATOM 5597 NE2 GLN 611 23.595 166.724 34.843 1.00 33 .48 c
ATOM 55g8 C GLN 611 26.95g 170.887 32.043 1.00 33 .48 c
ATOM 55g9 O GLN 611 28.103 170.613 31.669 1.00 33 .48 c
ATOM 5600 N LEU 612 26.156 171.702 31.365 1.00 33 .48 c
ATOM 5601 CA LEU 612 26.580 172.293 30.111 1.00 33 .48 c
ATOM 5602 CB LEU 612 25.365 172.853 29.384 1.00 33 .48 c
ATOM 5603 CG LEU 612 24.350 171.768 29.007 1.00 33 .48 c
ATOM 5604 CDl LEU 612 23.023 172.408 28.597 1.00 33 .48 c
ATOM 5605 CD2 LEU 612 24.g22 170.892 27.8g8 1.00 33 .48 c
ATOM 5606 C LEU 612 27.634 173.372 30.337 1.00 33 .48 c
ATOM 5607 O LEU 612 28.616 173.478 29.594 1.00 33 .48 c
ATOM 5608 N ALA 613 27.436 174.182 31.365 1.00 33 .48 c
ATOM 5609 CA ALA 613 28.411 175.215 31.653 1.00 33 .48 c
ATOM 5610 CB ALA 613 28.041 175.943 32.93g 1.00 33, .48 c
ATOM 5611 C ALA 613 2g.774 174.524 31.797 1.00 33, .48 c
ATOM 5612 0 ALA 613 30.788 175.002 31.252 1.00 33, .48 c
ATOM 5613 N GLU 614 2g.786 173.392 32.513 1.00 33, .48 c
ATOM 5614 CA GLU 614 31.026 172.642 32.73g 1.00 33, .48 c
ATOM 5615 CB GLU 614 30.77g 171.416 33.641 1.00 33, .48 c
ATOM 5616 CG GLU 614 30.671 171.704 35.161 1.00 33 .48 c
ATOM 5617 CD GLU 614 30.262 170.454 35.gg6 1.00 33 .48 c
ATOM 5618 OEl GLU 614 2g.055 170.086 36.000 1.00 33 .48 c
ATOM 5619 OE2 GLU 614 31.150 169.833 36.643 1.00 33 .48 c
ATOM 5620 C GLU 614 31.644 172.196 31.416 1.00 33 .48 c
ATOM 5621 0 GLU 614 32.762 172.591 31.086 1.00 33 .48 c
ATOM 5622 N ILE 615 30.898 171.391 30.658 1.00 33 .48 c
ATOM 5623 CA ILE 615 31.351 170.869 2g.367 1.00 33 .48 c
ATOM 5624 CB ILE 615 30.180 170.281 28.564 1.00 33, .48 c
ATOM 5625 CG2 ILE 615 30.667 169.780 27.225 1.00 33, .48 c
ATOM 5626 CGl ILE 615 29.523 169.157 2g.365 1.00 33 .48 c ATOM 5627 CDl ILE 615 28.348 168.503 28.683 1.00 33.48 C
ATOM 5628 C ILE 615 32.031 171.945 28.533 1.00 33 .48 c
ATOM 5629 0 ILE 615 32.806 171.643 27.630 1.00 33 .48 c
ATOM 5630 N ALA 616 31.722 173.203 28.815 1.00 33 .48 c
ATOM 5631 CA ALA 616 32.374 174.293 28.104 1.00 33.48 C
ATOM 5632 CB ALA 616 31.637 175.600 28.352 1.00 33 .48 c
ATOM 5633 C ALA 616 33.781 174.347 28.710 1.00 33 .48 c
ATOM 5634 0 ALA 616 34.622 173.491 28.422 1.00 33.48 c
ATOM 5635 N GLU 617 34.013 175.339 29.571 1.00 33 .48 c
ATOM 5636 CA GLU 617 35.298 175.515 30.257 1.00 33 .48 c
ATOM 5637 CB GLU 617 35.068 176.014 31.694 1.00 33 .48 c
ATOM 5638 CG GLU 617 35.9g4 177.141 32.170 1.00 33 .48 c
ATOM 5639 CD GLU 617 35.608 178.523 31.609 1.00 33 .48 c
ATOM 5640 OEl GLU 617 34.387 178.789 31.427 1.00 33 .48 c
ATOM 5641 OE2 GLU 617 36.526 179.353 31.370 1.00 33 .48 c
ATOM 5642 C GLU 617 36.014 174.164 30.304 1.00 33 .48 c
ATOM 5643 0 GLU 617 37.160 174.038 2g.874 1.00 33 .48 c
ATOM 5644 N SER 618 35.304 173.161 30.814 1.00 33 .48 c
ATOM 5645 CA SER 618 35.812 171.802 30.g52 1.00 33 .48 c
ATOM 5646 CB SER 618 34.711170.791 30.656 1.00 33 .48 c
ATOM 5647 OG SER 618 35.172 169.474 30.905 1.00 33 .48 c
ATOM 5648 C SER 618 36.g87 171.521 30.042 1.00 33.48 c
ATOM 5649 0 SER 618 36.758 170. giδ 28.964 1.00 33 .48 c
ATOM 5650 OXT SER 618 38.114 171.919 30.416 1.00 33 .48 c
TER 5651 SER 618 c
ATOM 5652 C GLY 354 38.642 124. g22 51.619 1.00 33.48 D
ATOM 5653 0 GLY 354 39.448 124.227 52.225 1.00 33 .48 D
ATOM 5654 N GLY 354 36.230 125.178 51.980 1.00 33 .48 D
ATOM 5655 CA GLY 354 37.276 124.3 6 51.264 1.00 33 .48 D
ATOM 5656 N LYS 355 38.908 126.163 51.239 1.00 33 .48 D
ATOM 5657 CA LYS 355 40.184 126.7g8 51.539 1.00 33 .48 D
ATOM 5658 CB LYS 355 40.5g7 127.731 50.39g 1.00 33 .48 D
ATOM 5659 CG LYS 355 3g.508 128.691 4g.g59 1.00 33 .48 D
ATOM 5660 CD LYS 355 3g.775 129.241 48.574 1.00 33 .48 D
ATOM 5661 CE LYS 355 39.792 128.122 47.555 1.00 33 .48 D
ATOM 5662 NZ LYS 355 40.228 128.593 46.207 1.00 33 .48 D
ATOM 5663 C LYS 355 3g.gg7 127.570 52.824 1.00 33 .48 D
ATOM 5664 0 LYS 355 40.877 128.292 53.274 1.00 33 .48 D
ATOM 5665 N TRP 356 38.831127.383 53.426 1.00 33 .48 D
ATOM 5666 CA TRP 356 38.518 128.069 54.665 1.00 33.48 D
ATOM 5667 CB TRP 356 37.260 128.935 54.511 1.00 33 .48 D
ATOM 5668 CG TRP 356 37.306 129. g22 53.373 1.00 33 .48 D
ATOM 5669 CD2 TRP 356 37.782 131.271 53.429 1.00 33 .48 D
ATOM 5670 CE2 TRP 356 37.584 131.836 52.154 1.00 33 .48 D ATOM 5671 CE3 TRP 356 38.355 132.055 54.432 1.00 33 .48 D
ATOM 5672 CDl TRP 356 36.862 129.728 52.0g6 1.00 33 .48 D
ATOM 5673 NEl TRP 356 37.021 130.873 51.357 1.00 33 .48 D
ATOM 5674 CZ2 TRP 356 37.g36 133.150 51.860 1.00 33.48 D
ATOM 5675 CZ3 TRP 356 38.702 133.346 54.140 1.00 33.48 D
ATOM 5676 CH2 TRP 356 38.4g3 133.885 52.866 1.00 33.48 D
ATOM 5677 C TRP 356 38.3ig 127.127 55.832 1.00 33.48 D
ATOM 5678 0 TRP 356 38.024 127.580 56.g26 1.00 33 .48 D
ATOM 567g N VAL 357 38.484 125.827 55.615 1.00 33.48 D
ATOM 5680 CA VAL 357 38.2g2 124.865 56.6g4 1.00 33 .48 D
ATOM 5681 CB VAL 357 38.373 123.438 56.184 1.00 33 .48 D
ATOM 5682 CGl VAL 357 38.35g 122.496 57.356 1.00 33 .48 D
ATOM 5683 CG2 VAL 357 37.214 123.142 55.264 1.00 33 .48 D
ATOM 5684 C VAL 357 39.287 125.007 57.835 1.00 33 .48 D
ATOM 5685 0 VAL 357 40.465 125.238 57.606 1.00 33 .48 D
ATOM 5686 N ILE 358 38.805 124.845 5g.061 1.00 33.48 D
ATOM 5687 CA ILE 358 39.632 124.967 60.252 1.00 33.48 D
ATOM 5688 CB ILE 358 3g.213 126.202 61.070 1.00 33.48 D
ATOM 5689 CG2 ILE 358 3g.602 126.040 62.530 1.00 33.48 D
ATOM 5690 CGl ILE 358 39.837 127.455 60.45g 1.00 33.48 D
ATOM 5691 CDl ILE 358 39.934 128.600 61.412 1.00 33.48 D
ATOM 56 2 C ILE 358 39.541 123.738 61.142 1.00 33.48 D
ATOM 56g3 0 ILE 358 38.450 123.296 61.464 1.00 33 .48 D
ATOM 5694 N ASP 359 40.685 123.188 61.544 1.00 33 .48 D
ATOM 5695 CA ASP 359 40.714 121. ggg 62.3g6 1.00 33 .48 D
ATOM 5696 CB ASP 359 42.112 121.363 62.3gθ 1.00 33.48 D
ATOM 5697 CG ASP 359 42.126 ιιg.g32 62.g61 1.00 33.48 D
ATOM 56g8 ODl ASP 35g 41.617 lig.716 64. ogo 1.00 33.48 D
ATOM 56g9 OD2 ASP 359 42.653 iig.021 62.275 1.00 33 .48 D
ATOM 5700 C ASP 359 40.341 122.353 63.828 1.00 33 .48 D
ATOM 5701 0 ASP 35 41.058 123.073 64.512 1.00 33 .48 D
ATOM 5702 N PRO 360 39.221 121.821 64.308 1.00 33 .48 D
ATOM 5703 CD PRO 360 38.471 120.750 63.641 1.00 33 .48 D
ATOM 5704 CA PRO 360 38.701 122.044 65.650 1.00 33 .48 D
ATOM 5705 CB PRO 360 37.703 120.910 65.814 1.00 33 .48 D
ATOM 5706 CG PRO 360 37.2ig 120.700 64.451 1.00 33 .48 D
ATOM 5707 C PRO 360 3g.770 121.998 66.730 1.00 33 .48 D
ATOM 5708 0 PRO 360 39.655 122.678 67.750 1.00 33 .48 D
ATOM 5709 N SER 361 40.802 121.185 66.514 1.00 33.48 D
ATOM 5710 CA SER 361 41.870 121.026 67.500 1.00 33.48 D
ATOM 5711 CB SER 361 42.674 119.772 67.202 1.00 33 .48 D
ATOM 5712 OG SER 361 43.287 119.886 65.g3g 1.00 33 .48 D
ATOM 5713 C SER 361 42.814 122.2og 67.564 1.00 33.48 D
ATOM 5714 0 SER 361 43.481 122.426 68.562 1.00 33.48 D ATOM 5715 N GLU 362 42.871122. g7 66.4g5 1.0033.48 D
ATOM 5716 CA GLU 362 43.755 124.12 66.461 1.00 33 .48 D
ATOM 5717 CB GLU 362 44.385 124.222 65.073 1.00 33 .48 D
ATOM 5718 CG GLU 362 44.993 122.8g8 64.608 1.00 33 .48 D
ATOM 57ig CD GLU 362 45.732 123.028 63.2g6 1.00 33 .48 D
ATOM 5720 OEl GLU 362 45.190 123.719 62.3gg 1.00 33 .48 D
ATOM 5721 OE2 GLU 362 46.838 122.444 63.163 1.00 33 .48 D
ATOM 5722 C GLU 362 43.004 125.416 66.803 1.00 33 .48 D
ATOM 5723 O GLU 362 43.524 126.520 66.654 1.00 33 .48 D
ATOM 5724 N LEU 363 41.775 125.255 67.276 1.00 33 .48 D
ATOM 5725 CA LEU 363 40.935 126.390 67.6ig 1.00 33 .48 D
ATOM 5726 CB LEU 363 39.648 126.361 66.805 1.00 33 .48 D
ATOM 5727 CG LEU 363 38.695 127.484 67.173 1.00 33 .48 D
ATOM 5728 CDl LEU 363 39.365 128.793 66.805 1.00 33 .48 D
ATOM 5729 CD2 LEU 363 37.366 127.314 66.456 1.00 33 .48 D
ATOM 5730 C LEU 363 40.578 126.338 6g.080 1.00 33 .48 D
ATOM 5731 O LEU 363 3g.g8i 125.365 6g.540 1.00 33 .48 D
ATOM 5732 N THR 364 40. gig 127.391 69.811 1.00 33 .48 D
ATOM 5733 CA THR 364 40.620 127.406 71.223 1.00 33, .48 D
ATOM 5734 CB THR 364 41.933 127.263 72.035 1.00 33, .48 D
ATOM 5735 OGl THR 364 41.884 128.056 73.225 1.00 33, .48 D
ATOM 5736 CG2 THR 364 43.103 127.658 71.189 1.00 33, .48 D
ATOM 5737 C THR 364 39.818 128.623 71.657 1.00 33 .48 D
ATOM 5738 O THR 364 40.113 129.745 71.273 1.00 33 .48 D
ATOM 5739 N PHE 365 38.773 128.367 72.438 1.00 33 .48 D
ATOM 5740 CA PHE 365 37.gog 12g.407 72.961 1.00 33 .48 D
ATOM 5741 CB PHE 365 36.4g7 128.878 73.164 1.00 33 .48 D
ATOM 5742 CG PHE 365 35.808 128.488 71.903 1.00 33 .48 D
ATOM 5743 CDl PHE 365 34.46g 128.775 71.719 1.00 33 .48 D
ATOM 5744 CD2 PHE 365 36.470 127.78g 70.923 1.00 33, .48 D
ATOM 5745 CEl PHE 365 33.803 128.362 70.580 1.00 33, .48 D
ATOM 5746 CE2 PHE 365 35.810 127.376 69.785 1.00 33, .48 D
ATOM 5747 CZ PHE 365 34.478 127.661 6g.616 1.00 33 .48 D
ATOM 5748 C PHE 365 38.442 12g.865 74.310 1.00 33 .48 D
ATOM 5749 O PHE 365 38.872 12g.037 75.107 1.00 33, .48 D
ATOM 5750 N VAL 366 38.403 131.167 74.591 1.00 33, .48 D
ATOM 5751 CA VAL 366 38.8g3 131.632 75.881 1.00 33, .48 D
ATOM 5752 CB VAL 366 40. iog 132.543 75.743 1.00 33, .48 D
ATOM 5753 CGl VAL 366 40.612 132.8g6 77.116 1.00 33, .48 D
ATOM 5754 CG2 VAL 366 41.191 131.866 74.941 1.00 33, .48 D
ATOM 5755 C VAL 366 37.883 132.373 76.747 1.00 33, .48 D
ATOM 5756 O VAL 366 37.917 132.220 77.970 1.00 33, .48 D
ATOM 5757 N GLN 367 37.007 133.175 76.124 1.00 33, ,48 D
ATOM 5758 CA GLN 367 35.988 133. g74 76.844 1.00 33, .48 D ATOM 5759 CB GLN 367 36.501 135.382 77.17g 1.00 33 .48 D
ATOM 5760 CG GLN 367 37.913 135.526 77.66g 1.00 33 .48 D
ATOM 5761 CD GLN 367 38.312 136. gs 77.813 1.00 33 .48 D
ATOM 5762 OEl GLN 367 39.480 137.324 78.048 1.00 33 .48 D
ATOM 5763 NE2 GLN 367 37.338 137.884 77.673 1.00 33 .48 D
ATOM 5764 C GLN 367 34.709 134.208 76.042 1.00 33 .48 D
ATOM 5765 0 GLN 367 34.770 134.454 74.837 1.00 33 .48 D
ATOM 5766 N GLU 368 33.553 134.145 76.706 1.00 33 .48 D
ATOM 5767 CA GLU 368 32.289 134.44g 76.025 1.00 33 .48 D
ATOM 5768 CB GLU 368 31.074 134.02g 76.862 1.00 33 .48 D
ATOM 5769 CG GLU 368 2g.763 134.016 76.057 1.00 33 .48 D
ATOM 5770 CD GLU 368 28.703 133.04g 76.617 1.00 33 .48 D
ATOM 5771 OEl GLU 368 27. 777 133.500 77.353 1.00 33 .48 D
ATOM 5772 OE2 GLU 368 28.808 131.826 76.320 1.00 33 .48 D
ATOM 5773 C GLU 368 32.42g 135. 63 75.gδg 1.00 33 .48 D
ATOM 5774 0 GLU 368 32.466 136.608 77.035 1.00 33 .48 D
ATOM 5775 N ILE 36 32.527 136.533 74.794 1.00 33 .48 D
ATOM 5776 CA ILE 36 32.770 137. g6g 74.676 1.00 33 .48 D
ATOM 5777 CB ILE 369 34.006 138.178 73.751 1.00 33 .48 D
ATOM 5778 CG2 ILE 369 33.5g6 138.374 72.307 1.00 33 .48 D
ATOM 5779 CGl ILE 369 34.820 13g.354 74.245 1.00 33 .48 D
ATOM 5780 CDl ILE 369 35.g67 13g.685 73.320 1.00 33 .48 D
ATOM 5781 C ILE 369 31.592 138.867 74.240 1.00 33 .48 D
ATOM 5782 0 ILE 369 31.625 140. og2 74.404 1.00 33 .48 D
ATOM 5783 N GLY 370 30.545 138.247 73.708 1.00 33 .48 D
ATOM 5784 CA GLY 370 29.388 138. g6 73.266 1.00 33 .48 D
ATOM 5785 C GLY 370 28.245 138.030 73.063 1.00 33 .48 D
ATOM 5786 0 GLY 370 28.456 136.880 72.712 1.00 33 .48 D
ATOM 5787 N SER 371 27.025 138.485 73.291 1.00 33 .48 D
ATOM 5788 CA SER 371 25.883 137.600 73.125 1.00 33 .48 D
ATOM 5789 CB SER 371 24.g05 137.741 74.297 1.00 33 .48 D
ATOM 5790 OG SER 371 25.37g 137.058 75.451 1.00 33 .48 D
ATOM 5791 C SER 371 25.155 137.850 71.829 1.00 33 .48 D
ATOM 5792 0 SER 371 25.731 138.362 70.862 1.00 33 .48 D
ATOM 5793 N GLY 372 23.880 137.483 71.830 1.00 33 .48 D
ATOM 5794 CA GLY 372 23.045 137.637 70.649 1.00 33 .48 D
ATOM 5795 C GLY 372 22.221 136.376 70.430 1.00 33 .48 D
ATOM 5796 0 GLY 372 22.770 135.277 70.279 1.00 33 .48 D
ATOM 5797 N GLN 373 2θ.goι 136.516 70.434 1.00 33 .48 D
ATOM 57g8 CA GLN 373 20.055 135.353 70.231 1.00 33 .48 D
ATOM 57gg CB GLN 373 18.573 135.757 70.303 1.00 33 .48 D
ATOM 5800 CG GLN 373 18.003 135.658 71.721 1.00 33 .48 D
ATOM 5801 CD GLN 373 16.g34 136.721 72.035 1.00 33 .48 D
ATOM 5802 OEl GLN 373 16.122 136.556 72.963 1.00 33 .48 D ATOM 5803 NE2 GLN 373 16.948 137.822 71.277 1.00 33.48 D
ATOM 5804 C GLN 373 20.379 134.615 6 . gig 1.00 33 .48 D
ATOM 5805 O GLN 373 19.g37 133.478 6δ.724 1.00 33 .48 D
ATOM 5806 N PHE 374 21.156 135.232 6δ.026 1.00 33 .48 D
ATOM 5807 CA PHE 374 21.506 134.538 66.779 1.00 33 .48 D
ATOM 5808 CB PHE 374 21.823 135.542 65.650 1.00 33 .48 D
ATOM 5809 CG PHE 374 23.18g 136.159 65.744 1.00 33 .48 D
ATOM 5810 CDl PHE 374 24.340 135.368 65.665 1.00 33 .48 D
ATOM 5811 CD2 PHE 374 23.32g 137.531 65.911 1.00 33 .48 D
ATOM 5812 CEl PHE 374 25.611 135.934 65.753 1.00 33 .48 D
ATOM 5813 CE2 PHE 374 24.602 138.117 65.9gδ 1.00 33 .48 D
ATOM 5814 CZ PHE 374 25.744 137.319 65.g20 1.00 33 .48 D
ATOM 5815 C PHE 374 22.723 133.618 67.035 1.00 33 .48 D
ATOM 5816 O PHE 374 22.g37 132.608 66.346 1.00 33 .48 D
ATOM 5817 N GLY 375 23.517 133. ggs 68.033 1.00 33 .48 D
ATOM 5818 CA GLY 375 24.6g7 133.232 68.382 1.00 33 .48 D
ATOM 5819 C GLY 375 25.667 134.038 6g.227 1.00 33.48 D
ATOM 5820 O GLY 375 25.611 135.267 6g.245 1.00 33 .48 D
ATOM 5821 N LEU 376 26.564 133.345 6g.g23 1.00 33 .48 D
ATOM 5822 CA LEU 376 27.545 133. ggg 70.773 1.00 33 .48 D
ATOM 5823 CB LEU 376 27.766 133.178 72.034 1.00 33 .48 D
ATOM 5824 CG LEU 376 26.706 133.367 73.101 1.00 33.48 D
ATOM 5825 CDl LEU 376 25.335 133.3g5 72.454 1.00 33.48 D
ATOM 5826 CD2 LEU 376 26.817 132.266 74.104 1.00 33 .48 D
ATOM 5827 C LEU 376 28.881134.195 70.102 1.00 33 .48 D
ATOM 5828 O LEU 376 2g.26g 133.420 6g.243 1.00 33 .48 D
ATOM 5829 N VAL 377 2g.58g 135.239 70.502 1.00 33 .48 D
ATOM 5830 CA VAL 377 30.gi7 135.4go 69.971 1.00 33 .48 D
ATOM 5831 CB VAL 377 31.018 136.884 69.310 1.00 33 .48 D
ATOM 5832 CGl VAL 377 30.222 137.δδO 70.085 1.00 33 .48 D
ATOM 5833 CG2 VAL 377 32.464 137.323 69.241 1.00 33 .48 D
ATOM 5834 C VAL 377 31.924 135.361 71.118 1.00 33 .48 D
ATOM 5835 O VAL 377 31.796 136.03δ 72.144 1.00 33 .48 D
ATOM 5836 N HIS 378 32.892 134.453 70.955 1.00 33.48 D
ATOM 5837 CA HIS 378 33.9ig 134.234 71.974 1.00 33 .48 D
ATOM 5838 CB HIS 378 34.164 132.746 72.250 1.00 33 .48 D
ATOM 5839 CG HIS 378 32.g72 131.988 72.735 1.00 33 .48 D
ATOM 5840 CD2 HIS 378 32.677 131.485 73.957 1.00 33 .48 D
ATOM 5841 NDl HIS 378 31.947 131.600 71.901 1.00 33.48 D
ATOM 5842 CEl HIS 378 31.072 130.886 72.587 1.00 33.48 D
ATOM 5843 NE2 HIS 378 31.491 130.802 73.837 1.00 33 .48 D
ATOM 5844 C HIS 378 35.239 134. δOl 71.489 1.00 33 .48 D
ATOM 5845 O HIS 378 35.395 135. og2 70.306 1.00 33 .48 D
ATOM 5846 N LEU 379 36.188 134.916 72.416 1.00 33 .48 D ATOM 5847 CA LEU 379 37.532 135.406 72.138 1.00 33.48 D
ATOM 584δ CB LEU 379 37.86g 136.558 73.067 1.00 33.48 D
ATOM 5849 CG LEU 379 3g.2g6 137.051 72.912 1.00 33.48 D
ATOM 5850 CDl LEU 379 3g.53 137.424 71.485 1.00 33.48 D
ATOM 5851 CD2 LEU 379 39.535 138.222 73.822 1.00 33.4δ D
ATOM 5852 C LEU 379 3δ.564 134.28g 72.344 1.00 33.4δ D
ATOM 5853 0 LEU 379 3δ.660 133.717 73.431 1.00 33.4δ D
ATOM 5854 N GLY 380 39.336 133. 77 71.308 1.00 33.4δ D
ATOM 5855 CA GLY 380 40.33δ 132.935 71.441 1.00 33.4δ D
ATOM 5856 C GLY 380 41.483 133.096 70.466 1.00 33.4δ D
ATOM 5857 0 GLY 3δO 41.847 134.207 70.117 1.00 33.48 D
ATOM 585δ N TYR 381 42.076 131.986 70.045 1.00 33.48 D
ATOM 5δ59 CA TYR 381 43.160 132.039 69.07g 1.00 33.48 D
ATOM 5δ60 CB TYR 381 44.515 132.280 6g.764 1.00 33.48 D
ATOM 5δ61 CG TYR 381 44.774 131.496 71.026 1.00 33.48 D
ATOM 5862 CDl TYR 381 44.432 132.010 72.268 1.00 33.48 D
ATOM 5863 CEl TYR 381 44.705 131.320 73.424 1.00 33.48 D
ATOM 5864 CD2 TYR 381 45.3g2 130.262 70.g80 1.00 33.48 D
ATOM 5865 CE2 TYR 381 45.668 129.565 72.130 1.00 33.48 D
ATOM 5δ66 CZ TYR 381 45.327 130.096 73.350 1.00 33.48 D
ATOM 5867 OH TYR 381 45.631129.405 74.4gg 1.00 33.48 D
ATOM 586δ C TYR 381 43.197 130.785 68.212 1.00 33.48 D
ATOM 5δ6g 0 TYR 381 42.601129.771 68.567 1.00 33.48 D
ATOM 5δ70 N TRP 3δ2 43.900 130.874 67.0δ0 1.00 33.48 D
ATOM 5δ71 CA TRP 3δ2 44.002 129.791 66. ogg 1.00 33.48 D
ATOM 5872 CB TRP 3δ2 42.gg6 130.071 64.gδ3 1.00 33.48 D
ATOM 5873 CG TRP 3δ2 43.ig2 129.348 63.708 1.00 33.48 D
ATOM 5874 CD2 TRP 382 43.336 129. g35 62.411 1.00 33.48 D
ATOM 5875 CE2 TRP 382 43.3g3 12δ.88g 61.487 1.00 33.48 D
ATOM 5876 CE3 TRP 382 43.417 131.24δ 61.943 1.00 33.48 D
ATOM 5877 CDl TRP 382 43.176 128.017 63.524 1.00 33.48 D
ATOM 5δ7δ NEl TRP 382 43.2g2 127.722 62.192 1.00 33.48 D
ATOM 5δ7g CZ2 TRP 382 43.52g 12g.l06 60.122 1.00 33.48 D
ATOM 5δδ0 CZ3 TRP 3δ2 43.554 131.464 60.5δ7 1.00 33.48 D
ATOM 5δδl CH2 TRP 3δ2 43.60g 130.398 5g.6g4 1.00 33.48 D
ATOM 5δδ2 C TRP 3δ2 45.408 129.629 65.519 1.00 33.48 D
ATOM 5883 0 TRP 3δ2 45.g52 130.545 64.923 1.00 33.48 D
ATOM 5884 N LEU 3δ3 45.g71 128.439 65.6gi 1.00 33.4δ D
ATOM 5885 CA LEU 383 47.310 128.093 65.232 1.00 33.4δ D
ATOM 5886 CB LEU 383 47.4gθ 128.409 63.756 1.00 33.4δ D
ATOM 5887 CG LEU 383 46.608 127.535 62.δ77 1.00 33.4δ D
ATOM 5888 CDl LEU 383 47.156 127.4δδ 61.480 1.00 33.4δ D
ATOM 588g CD2 LEU 383 46.556 126.154 63.451 1.00 33.4δ D
ATOM 58go C LEU 383 48.3g7 128.761 66.053 1.00 33.4δ D ATOM 58gi 0 LEU 383 49.447 128.177 66.253 1.00 33.48 D
ATOM 58 2 N ASN 384 48.146 129.980 66.521 1.00 33.48 D
ATOM 5δg3 CA ASN 384 49.0δ4 130.713 67.371 1.00 33.48 D
ATOM 5δg4 CB ASN 384 50.007 131.596 66.550 1.00 33.48 D
ATOM 5δg5 CG ASN 3δ4 49.277 132.376 65.505 1.00 33.4δ D
ATOM 5δg6 ODl ASN 384 4δ.330 133. ogg 65.801 1.00 33.4δ D
ATOM 5δg7 ND2 ASN 384 49.712 132.243 64.262 1.00 33.4δ D
ATOM 5δgδ C ASN 384 4δ.306 131.555 68.380 1.00 33.4δ D
ATOM 58gg 0 ASN 384 47.0δ4 131.514 68.420 1.00 33.4δ D
ATOM sgoo N ALA 385 49.007 132.323 εg.igg 1.00 33.4δ D
ATOM sgoi CA ALA 385 4δ.348 133.123 70.224 1.00 33.4δ D
ATOM 5go2 CB ALA 385 49.365 133.508 71.308 1.00 33.4δ D
ATOM 5g03 C ALA 385 47.624 134.363 69.696 1.00 33.4δ D
ATOM 5g04 0 ALA 385 47.070 135.137 70.467 1.00 33.48 D
ATOM sgos N ASP 386 47.629 134.558 68.384 1.00 33.48 D
ATOM 5g06 CA ASP 386 46.930 135.6gg 67.810 1.00 33.48 D
ATOM 5g07 CB ASP 386 47.072 135.726 66.284 1.00 33.48 D
ATOM sgos CG ASP 386 48.464 136. Oδδ 65.822 1.00 33.48 D
ATOM sgog ODl ASP 386 4g.306 136.451 66.654 1.00 33.48 D
ATOM sgio OD2 ASP 3δ6 48.720 136.016 64.614 1.00 33.48 D
ATOM 5911 C ASP 3δ6 45.446 135.568 68.162 1.00 33.48 D
ATOM 5gi2 0 ASP 3δ6 44.816 134.546 67.854 1.00 33.48 D
ATOM 5 i3 N LYS 3δ7 44.8gi 136.5g5 68.803 1.00 33.4δ D
ATOM 5gi4 CA LYS 3δ7 43.4δ4 136.582 69.172 1.00 33.4δ D
ATOM s is CB LYS 3δ7 43.171 137.748 70.103 1.00 33.4δ D
ATOM 5gi6 CG LYS 3δ7 43.7δ2 137.56g 71.476 1.00 33.48 D
ATOM 5917 CD LYS 387 44.027 138.8δ4 72.212 1.00 33.48 D
ATOM 5918 CE LYS 387 44.δ40 138.656 73.504 1.00 33.48 D
ATOM 59ig NZ LYS 3δ7 46.177 137. gg6 73.293 1.00 33.4δ D
ATOM 5g20 C LYS 3δ7 42.634 136.652 67.923 1.00 33.4δ D
ATOM 5g21 0 LYS 3δ7 43.032 137.231 66.924 1.00 33.4δ D
ATOM 5g22 N VAL 3δδ 41.467 136.034 67.984 1.00 33.4δ D
ATOM 5923 CA VAL 388 40.535 135. ggo 66.86δ 1.00 33.4δ D
ATOM 5924 CB VAL 388 40.707 134.684 66.041 1.00 33.4δ D
ATOM 5925 CGl VAL 388 42.176 134.442 65.753 1.00 33.4δ D
ATOM 5926 CG2 VAL 388 40.105 133.4go 66.787 1.00 33.48 D
ATOM 5927 C VAL 388 39.139 135.991 67.464 1.00 33.48 D
ATOM 5928 0 VAL 388 38.976 135.794 68.666 1.00 33.48 D
ATOM 592g N ALA 389 38.126 136.200 66.637 1.00 33.48 D
ATOM 5g30 CA ALA 389 36.762 136.194 67.151 1.00 33.48 D
ATOM 5g31 CB ALA 389 36.05g 137.501 66.807 1.00 33.48 D
ATOM 5932 C ALA 38 36.000 135.006 66.577 1.00 33.4δ D
ATOM 5933 0 ALA 3δg 36.063 134.744 65.377 1.00 33.4δ D
ATOM 5934 N ILE 3go 35.284 134.293 67.439 1.00 33.4δ D ATOM 5935 CA ILE 3go 34.532 133.129 67.009 1.00 33.48 D
ATOM 5936 CB ILE 390 34.968 131.886 67.800 1.00 33.48 D
ATOM 5937 CG2 ILE 390 34.678 130.629 67.014 1.00 33.48 D
ATOM 5938 CGl ILE 390 36.457 131.953 6δ.09δ 1.00 33.48 D
ATOM 593g CDl ILE 390 36.848 131.107 6g.2δ7 1.00 33.48 D
ATOM 5940 c ILE 390 33.021 133.299 67.ig7 1.00 33.48 D
ATOM 5941 0 ILE 390 32.531 133.363 6δ.328 1.00 33.48 D
ATOM 5942 N LYS 391 32.296 133.368 66.0δ2 1.00 33.48 D
ATOM 5943 CA LYS 391 30.843 133.491 66.105 1.00 33.48 D
ATOM 5944 CB LYS 391 30.295 134.229 64.δ72 1.00 33.48 D
ATOM 5945 CG LYS 391 30.170 135.751 64.982 1.00 33.48 D
ATOM 5946 CD LYS 391 29.617 136.326 63.672 1.00 33.48 D
ATOM 5947 CE LYS 391 29.782 137. δ52 63.565 1.00 33.48 D
ATOM 5948 NZ LYS 391 29.736 138.362 62.139 1.00 33.48 D
ATOM 5949 c LYS 391 30.292 132.086 66.095 1.00 33.48 D
ATOM 5950 0 LYS 391 30.250 131.433 65.066 1.00 33.48 D
ATOM 5951 N THR 392 29.877 131.622 67.256 1.00 33.48 D
ATOM 5952 CA THR 392 29.318 130.297 67.382 1.00 33.48 D
ATOM 5953 CB THR 392 29.ιgo 129. 30 6δ.δ52 1.00 33.48 D
ATOM 5954 OGl THR 392 30.420 130.247 69.513 1.00 33.48 D
ATOM 5955 CG2 THR 392 28.893 128.462 69.013 1.00 33.48 D
ATOM 5956 c THR 392 27.943 130.293 66.737 1.00 33.48 D
ATOM 5957 0 THR 392 27.497 129.269 66.21δ 1.00 33.48 D
ATOM 595δ N PHE 403 23.059 130.825 59.004 1.00 33.48 D
ATOM sgsg CA PHE 403 24.477 130.678 59.362 1.00 33.48 D
ATOM 5g60 CB PHE 403 24.682 12g.483 60.306 1.00 33.48 D
ATOM 5961 CG PHE 403 25.648 12g.75δ 61.425 1.00 33.48 D
ATOM 5962 CDl PHE 403 25.355 i2g.34 62.726 1.00 33.48 D
ATOM 5g63 CD2 PHE 403 26.813 130.479 61.ig6 1.00 33.4δ D
ATOM 5964 CEl PHE 403 26.204 129.664 63.777 1.00 33.48 D
ATOM 5965 CE2 PHE 403 27.661 130.794 62.239 1.00 33.48 D
ATOM 5g66 CZ PHE 403 27.357 130.390 63.530 1.00 33.48 D
ATOM 5g67 C PHE 403 25.414 130.509 58.162 1.00 33.48 D
ATOM 5g6 0 PHE 403 25.804 131.496 57.520 1.00 33.48 D
ATOM 5g6 N ILE 404 25.771 129.256 57.869 1.00 33.48 D
ATOM 5 70 CA ILE 404 26.698 12δ.966 56.770 1.00 33.48 D
ATOM 5g71 CB ILE 404 26.620 127.46δ 56.295 1.00 33.48 D
ATOM 5 72 CG2 ILE 404 27.670 127.200 55.206 1.00 33.48 D
ATOM 5g73 CGl ILE 404 26.886 126.516 57.470 1.00 33.48 D
ATOM 5g74 CDl ILE 404 25.738 126.445 58.491 1.00 33.48 D
ATOM 5 75 C ILE 404 26.471 129. δ9δ 55.570 1.00 33.48 D
ATOM 5g76 0 ILE 404 27.436 130.470 55.032 1.00 33.4δ D
ATOM 5g77 N GLU 405 25.212 130.066 55.158 1.00 33.48 D
ATOM 5g7δ CA GLU 405 24.940 130.950 54.032 1.00 33.48 D ATOM 597g CB GLU 405 23.441 131.017 53.734 1.00 33..48 D
ATOM 5g80 CG GLU 405 22. δ34 129.688 53.263 1.00 33. .48 D
ATOM 5g81 CD GLU 405 23. 747 128.915 52.298 1.00 33. .48 D
ATOM 5 82 OEl GLU 405 23. 305 127.841 51.798 1.00 33. .48 D
ATOM 5gδ3 OE2 GLU 405 24.897 12g.371 52.046 1.00 33, .48 D
ATOM 5g84 C GLU 405 25 . 506 132.340 54.316 1.00 33, ,48 D
ATOM 5985 O GLU 405 26.020 133. oog 53.407 1.00 33, .48 D
ATOM 5986 N GLU 406 25.419 132.776 55.570 1.00 33, .48 D
ATOM 5987 CA GLU 406 25 .990 134.065 55.937 1.00 33, .48 D
ATOM 59δδ CB GLU 406 25 .954 134.260 57.460 1.00 33, .48 D
ATOM s g CG GLU 406 27. 281 134.724 58.0δg 1.00 33, .48 D
ATOM sggo CD GLU 406 27.167 134. 76 5g.600 1.00 33, .48 D
ATOM sggi OEl GLU 406 26. 580 134.123 60.306 1.00 33, .48 D
ATOM 5gg2 OE2 GLU 406 27. 670 136.020 60.0δ2 1.00 33, .48 D
ATOM 5993 C GLU 406 27.429 133. g43 55.466 1.00 33, .48 D
ATOM 59g4 O GLU 406 27.925 134.767 54.6gi 1.00 33, .48 D
ATOM s gs N ALA 407 28.077 132.868 55.gi5 1.00 33, .48 D
ATOM 5gg6 CA ALA 407 29.463 132.587 55.561 1.00 33, .48 D
ATOM 5gg7 CB ALA 407 29.892 131.251 56.141 1.00 33, .48 D
ATOM sggδ C ALA 407 29.644 132.574 54.055 1.00 33, .48 D
ATOM sggg O ALA 407 30. 644 133.06 53.53g 1.00 33, .48 D
ATOM 6000 N GLU 408 28. 680 132.026 53.334 1.00 33, .48 D
ATOM 6001 CA GLU 408 28 .852 131.984 51.902 1.00 33 .48 D
ATOM 6002 CB GLU 408 27. 619 131.411 51.207 1.00 33 .48 D
ATOM 6003 CG GLU 408 27.803 131.308 4g.6δ3 1.00 33, .48 D
ATOM 6004 CD GLU 408 29. 167 130.730 4g.277 1.00 33, .48 D
ATOM 6005 OEl GLU 408 29.476 130.738 48.062 1.00 33 .48 D
ATOM 6006 OE2 GLU 408 29.927 130.268 50.164 1.00 33 .48 D
ATOM 6007 C GLU 408 29.215 133.345 51.311 1.00 33 .48 D
ATOM 6008 O GLU 408 30. 157 133.438 50.513 1.00 33 .48 D
ATOM 600g N VAL 409 28.496 134.400 51.6g3 1.00 33, .48 D
ATOM 6010 CA VAL 409 28.827 135.726 51.154 1.00 33 .48 D
ATOM 6011 CB VAL 409 27.717 136. δOδ 51.455 1.00 33 .48 D
ATOM 6012 CGl VAL 409 28.228 137. 30 52.467 1.00 33 .48 D
ATOM 6013 CG2 VAL 409 27. 315 137.52δ 50.168 1.00 33 .48 D
ATOM 6014 C VAL 409 30.149 136.168 51.781 1.00 33 .48 D
ATOM 6015 O VAL 409 31.003 136.772 51.112 1.00 33, .48 D
ATOM 6016 N MET 410 30. 311 135.846 53.062 1.00 33 .48 D
ATOM 6017 CA MET 410 31. 526 136.192 53.775 1.00 33 .48 D
ATOM 6018 CB MET 410 31.496 135.596 55.181 1.00 33 .48 D
ATOM 60ig CG MET 410 30. 5 53 136.314 56.115 1.00 33 .48 D
ATOM 6020 SD MET 410 30. 734 138.117 55.gθδ 1.00 33 .48 D
ATOM 6021 CE MET 410 32 . 3 59 138.471 56.732 1.00 33 .48 D
ATOM 6022 C MET 410 32 .782 135.716 53.043 1.00 33 .48 D ATOM 6023 O MET 410 33.781 136.427 52.974 1.00 33.48 D
ATOM 6024 N MET 411 32.727 134.513 52.486 1.00 33.48 D
ATOM 6025 CA MET 411 33.875 133. g72 51.785 1.00 33.48 D
ATOM 6026 CB MET 411 33.675 132.490 51.523 1.00 33.48 D
ATOM 6027 CG MET 411 33.757 131.643 52.753 1.00 33.48 D
ATOM 6028 SD MET 411 33.2g4 12g.951 52.370 1.00 33.48 D
ATOM 602g CE MET 411 32.151 129.534 53.759 1.00 33.4δ D
ATOM 6030 C MET 411 34.12g 134.679 50.468 1.00 33.4δ D
ATOM 6031 O MET 411 35.237 134.603 49.909 1.00 33.48 D
ATOM 6032 N LYS 412 33.110 135.378 49.g7δ 1.00 33.48 D
ATOM 6033 CA LYS 412 33.218 136.050 48.6g4 1.00 33.4δ D
ATOM 6034 CB LYS 412 31.843 136.140 48.017 1.00 33.4δ D
ATOM 6035 CG LYS 412 31.0g6 134.812 47.871 1.00 33.4δ D
ATOM 6036 CD LYS 412 30.27g 134.786 46.573 1.00 33.4δ D
ATOM 6037 CE LYS 412 29.307 133.601 46.512 1.00 33.4δ D
ATOM 603δ NZ LYS 412 28.0g8 133.7δ5 47.3g6 1.00 33.48 D
ATOM 603g C LYS 412 33.7g3 137.440 4δ.791 1.00 33.48 D
ATOM 6040 0 LYS 412 34.707 137. OO 4δ.050 1.00 33.4δ D
ATOM 6041 N LEU 413 33.248 138.224 49.707 1.00 33.4δ D
ATOM 6042 CA LEU 413 33.673 13g.604 49.862 1.00 33.4δ D
ATOM 6043 CB LEU 413 32.687 140.330 50.772 1.00 33.4δ D
ATOM 6044 CG LEU 413 31.252 13g.822 50.594 1.00 33.4δ D
ATOM 6045 CDl LEU 413 30.402 140.270 51.763 1.00 33.4δ D
ATOM 6046 CD2 LEU 413 30.6δ6 140.310 49.274 1.00 33.4δ D
ATOM 6047 C LEU 413 35.062 i3g.6g6 50.443 1.00 33.48 D
ATOM 604δ O LEU 413 35.575 138.742 51.011 1.00 33.48 D
ATOM 604g N SER 414 35.667 140.861 50.295 1.00 33.48 D
ATOM 6050 CA SER 414 36.ggo 141.107 50.830 1.00 33.48 D
ATOM 6051 CB SER 414 38.02δ 140.2go 50.102 1.00 33.48 D
ATOM 6052 OG SER 414 39.311 140.773 50.436 1.00 33.4δ D
ATOM 6053, C SER 414 37.32g 142.572 50.676 1.00 33.4δ D
ATOM 6054 O SER 414 37.222 143.124 4g.575 1.00 33.4δ D
ATOM 6055 N HIS 415 37.752 143.192 51.775 1.00 33.4δ D
ATOM 6056 CA HIS 415 38.0g2 144.606 51.775 1.00 33.48 D
ATOM 6057 CB HIS 415 36.8g8 145.407 51.26δ 1.00 33.48 D
ATOM 605δ CG HIS 415 37.113 146.881 51.284 1.00 33.48 D
ATOM 605g CD2 HIS 415 37.421 147.747 50.2g2 1.00 33.48 D
ATOM 6060 NDl HIS 415 37.048 147.628 52.440 1.00 33.4δ D
ATOM 6061 CEl HIS 415 37.306 148.892 52.15g 1.00 33.4δ D
ATOM 6062 NE2 HIS 415 37.536 148.991 50.863 1.00 33.4δ D
ATOM 6063 C HIS 415 38.427 145.005 53.191 1.00 33.4δ D
ATOM 6064 0 HIS 415 37.722 144.639 54.110 1.00 33.4δ D
ATOM 6065 N PRO 416 39.503 145.770 53.380 1.00 33.4δ D
ATOM 6066 CD PRO 416 40.261146.347 52.268 1.00 33.4δ D ATOM 6067 CA PRO 416 40.023 146.271 54.652 1.00 33.,48 D
ATOM 6068 CB PRO 416 41.011 147.338 54.222 1.00 33. ,48 D
ATOM 6069 CG PRO 416 41. 514 146.823 52.963 1.00 33, .48 D
ATOM 6070 C PRO 416 38. gg6 146.833 55.615 1.00 33, .48 D
ATOM 6071 O PRO .416 3g . iδ6 146.771 56.822 1.00 33, .48 D
ATOM 6072 N LYS 417 37. gιo 147.391 55.095 1.00 33, .48 D
ATOM 6073 CA LYS 417 36.δg5 147.969 55.958 1.00 33, .48 D
ATOM 6074 CB LYS 417 36.368 149.272 55.354 1.00 33, .48 D
ATOM 6075 CG LYS 417 37.432 150.352 55.284 1.00 33, .48 D
ATOM 6076 CD LYS 417 38.026 150.596 56.662 1.00 33, .48 D
ATOM 6077 CE LYS 417 39.538 150.792 56.615 1.00 33, .48 D
ATOM 6078 NZ LYS 417 39.966 151.992 55.84δ 1.00 33, .48 D
ATOM 6079 C LYS 417 35.753 147.032 56.2δδ 1.00 33, .48 D
ATOM 6080 O LYS 417 34.676 147.471 56.681 1.00 33, .48 D
ATOM 6081 N LEU 418 35.9gi 145.737 56.123 1.00 33, .48 D
ATOM 6082 CA LEU 418 35.000 144.718 56.463 1.00 33, .48 D
ATOM 6083 CB LEU 418 34.4g7 143. g98 55.227 1.00 33, .48 D
ATOM 6084 CG LEU 418 33.g61144. 20 54.143 1.00 33, .48 D
ATOM 6085 CDl LEU 41δ 33.439 144.066 52.986 1.00 33, .48 D
ATOM 6086 CD2 LEU 418 32.859 145.817 54.724 1.00 33, .48 D
ATOM 6087 C LEU 418 35.712 143.720 57.352 1.00 33, .48 D
ATOM 6088 O LEU 418 36.877 143.393 57.109 1.00 33, .48 D
ATOM 6089 N VAL 419 35.036143.257 58.394 1.00 33, .48 D
ATOM 6090 CA VAL 419 35.633 142.284 59.2g4 1.00 33, .48 D
ATOM 6091 CB VAL 419 34.613 141.758 60.270 1.00 33, .48 D
ATOM 6092 CGl VAL 419 35.29g 140.981 61.335 1.00 33 .48 D
ATOM 6093 CG2 VAL 419 33.832 142.900 60.853 1.00 33, .48 D
ATOM 604 C VAL 419 36.074 141.136 58.417 1.00 33 .48 D
ATOM 60g5 O VAL 419 35.239 140.520 57.765 1.00 33, .48 D
ATOM 60g6 N GLN 420 37.372 140.850 58.375 1.00 33, .48 D
ATOM 60g7 CA GLN 420 37.849 139.766 57.522 1.00 33, .48 D
ATOM 6ogδ CB GLN 420 39.364139.807 57.361 1.00 33, .48 D
ATOM 6ogg CG GLN 420 39.876138.724 56.438 1.00 33, .48 D
ATOM 6100 CD GLN 420 39.250138.797 55.054 1.00 33, .48 D
ATOM 6101 OEl GLN 420 38.992 137.772 54.406 1.00 33 .48 D
ATOM 6102 NE2 GLN 420 39.012 140.021 54.585 1.00 33, .48 D
ATOM 6103 C GLN 420 37.445 138.409 58.053 1.00 33, .48 D
ATOM 6104 O GLN 420 37.108 138.256 5g.218 1.00 33 .48 D
ATOM 6105 N LEU 421 37.462137.411 57.ig3 1.00 33, .48 D
ATOM 6106 CA LEU 421 37.0g3 136.087 57.634 1.00 33 .48 D
ATOM 6107 CB LEU 421 35.890135.609 56.814 1.00 33 .48 D
ATOM 6108 CG LEU 421 35.256134.245 57.061 1.00 33 .48 D
ATOM 6iog CDl LEU 421 36.006133.223 56.270 1.00 33 .48 D
ATOM 6110 CD2 LEU 421 35.254133.912 58.536 1.00 33 .48 D ATOM 6111 c LEU 421 38.316 135.181 57.493 1.00 33.48 D
ATOM 6112 0 LEU 421 3g.ιoo 135.306 56.551 1.00 33.48 D
ATOM 6113 N TYR 422 38.491 134.291 58.461 1.00 33.48 D
ATOM 6114 CA TYR 422 39.631 133.382 5δ.475 1.00 33.4δ D
ATOM 6115 CB TYR 422 40.267 133.376 59.δ62 1.00 33.48 D
ATOM 6116 CG TYR 422 4θ.ggε 134.647 60.191 1.00 33.48 D
ATOM 6117 CDl TYR 422 41.403 134. gis 61.479 1.00 33.4δ D
ATOM 6118 CEl TYR 422 42.114 136.053 61.768 1.00 33.4δ D
ATOM 6119 CD2 TYR 422 41.319 135.558 59.199 1.00 33.4δ D
ATOM 6120 CE2 TYR 422 42.032 136.696 59.478 1.00 33.4δ D
ATOM 6121 CZ TYR 422 42.427 136. g3 60.763 1.00 33.4δ D
ATOM 6122 OH TYR 422 43.139 138.072 61.056 1.00 33.4δ D
ATOM 6123 C TYR 422 39.276 131. g63 58.075 1.00 33.4δ D
ATOM 6124 0 TYR 422 40.023 131.315 57.351 1.00 33.4δ D
ATOM 6125 N GLY 423 38.141 131.479 58.555 1.00 33.4δ D
ATOM 6126 CA GLY 423 37.734 130.137 58.20δ 1.00 33.4δ D
ATOM 6127 C GLY 423 36.552 129.63g 59.002 1.00 33.4δ D
ATOM 612δ 0 GLY 423 36.265 130.140 60.073 1.00 33.4δ D
ATOM 6129 N VAL 424 35.86δ 128.637 5δ.472 1.00 33.4δ D
ATOM 6130 CA VAL 424 34.714 128.070 5g.l43 1.00 33.4δ D
ATOM 6131 CB VAL 424 33.513 127. 7 5δ.l96 1.00 33.4δ D
ATOM 6132 CGl VAL 424 33.161 129.352 57.6δ7 1.00 33.4δ D
ATOM 6133 CG2 VAL 424 33.δ36 127.055 57.032 1.00 33.4δ D
ATOM 6134 C VAL 424 34.973 126.673 59.656 1.00 33.4δ D
ATOM 6135 0 VAL 424 35.704 125.900 59.050 1.00 33.4δ D
ATOM 6136 N CYS 425 34.361 126.358 60.7δ5 1.00 33.4δ D
ATOM 6137 CA CYS 425 34.461 125.033 61.363 1.00 33.4δ D
ATOM 613δ CB CYS 425 34.710 125.082 62.δ61 1.00 33.4δ D
ATOM 613g SG CYS 425 36.344 125.533 63.346 1.00 33.4δ D
ATOM 6140 C CYS 425 33.09δ 124.427 61.165 1.00 33.48 D
ATOM 6141 0 CYS 425 32.210 124.682 61.971 1.00 33.48 D
ATOM 6142 N LEU 426 32. gig 123.654 60.097 1.00 33.4δ D
ATOM 6143 CA LEU 426 31.641123.006 59.δ41 1.00 33.4δ D
ATOM 6144 CB LEU 426 31.620 122.393 5δ.453 1.00 33.48 D
ATOM 6145 CG LEU 426 30.δ50 123.157 57.380 1.00 33.48 D
ATOM 6146 CDl LEU 426 31.616 124.409 56.g54 1.00 33.4δ D
ATOM 6147 CD2 LEU 426 30.632 122.218 56.185 1.00 33.4δ D
ATOM 614δ C LEU 426 31.393 121.908 60.871 1.00 33.4δ D
ATOM 614g 0 LEU 426 31.202 120.745 60.522 1.00 33.4δ D
ATOM 6150 N ILE 431 30.146 124.629 66.066 1.00 33.4δ D
ATOM 6151 CA ILE 431 29.94g 125.160 64.713 1.00 33.4δ D
ATOM 6152 CB ILE 431 2δ.4δ6 125.041 64.256 1.00 33.4δ D
ATOM 6153 CG2 ILE 431 2δ.43δ 124.820 62.742 1.00 33.4δ D
ATOM 6154 CGl ILE 431 27.787 123.902 65.015 1.00 33.4δ D ATOM 6155 CDl ILE 431 27.443 124.221 66.476 1..00 33,.48 D
ATOM 6156 c ILE 431 30.313 126.633 64.733 1. .00 33, .48 D
ATOM 6157 0 ILE 431 2g .624 127.436 65.347 1. .00 33, .48 D
ATOM 615δ N CYS 432 31. 370 127.009 64.033 1. .00 33, .48 D
ATOM 6159 CA CYS 432 31.769 128 . 385 64.103 1. .00 33 .48 D
ATOM 6160 CB CYS 432 32.69g 128 . 554 65.296 1. .00 33 .48 D
ATOM 6161 SG CYS 432 33 .865 127. 205 65.513 1. .00 33 .48 D
ATOM 6162 c CYS 432 32.415 128. gg2 62.903 1. .00 33 .48 D
ATOM 6163 0 CYS 432 32.88g 128.303 62.015 1. .00 33 .48 D
ATOM 6164 N LEU 433 32 .406 130.318 62.903 1. .00 33 .48 D
ATOM 6165 CA LEU 433 33 .017 131.129 61.870 1. ,00 33, .48 D
ATOM 6166 CB LEU 433 32 .042 132.184 61.360 1. ,00 33 .48 D
ATOM 6167 CG LEU 433 30.849 131.784 60.49g 1. ,00 33 .48 D
ATOM 616δ CDl LEU 433 30.473 130.351 60.720 1. ,00 33 .48 D
ATOM 6169 CD2 LEU 433 29.701132.691 60.844 1. ,00 33 .48 D
ATOM 6170 C LEU 433 34.111131.804 62.662 1. ,00 33, .48 D
ATOM 6171 O LEU 433 33 .895 132.167 63.807 1. ,00 33, .48 D
ATOM 6172 N VAL 434 35 .283 131.961 62.07g 1. ,00 33, .48 D
ATOM 6173 CA VAL 434 36.360 132.5δδ 62.80g 1. 00 33, .48 D
ATOM 6174 CB VAL 434 37. 5δ5 131.639 62.8g5 1. 00 33, .4δ D
ATOM 6175 CGl VAL 434 3δ .650 132.235 63.780 1. 00 33, .48 D
ATOM 6176 CG2 VAL 434 37.163 130.286 63.461 1. 00 33, .48 D
ATOM 6177 C VAL 434 36.706 133. δgg 62.114 1. 00 33, .48 D
ATOM 6178 O VAL 434 36. δ92 133. g42 60.904 1. 00 33, .48 D
ATOM 6179 N PHE 435 36.754 134. g77 62.887 1. 00 33, .48 D
ATOM 6180 CA PHE 435 37.042 136.2g5 62.336 1. 00 33, .48 D
ATOM 6181 CB PHE 435 35 .828 137.216 62.452 1. 00 33, .48 D
ATOM 61δ2 CG PHE 435 34.630 136.743 61.703 1. 00 33, .48 D
ATOM 6183 CDl PHE 435 34. 501 136. gδδ 60.360 1. 00 33, .48 D
ATOM 6184 CD2 PHE 435 33 .628 136.042 62.353 1. 00 33, .48 D
ATOM 6185 CEl PHE 435 33 . 3g6 136.543 59.684 1. 00 33, .48 D
ATOM 61δ6 CE2 PHE 435 32. 522 135.5g2 61.681 1. 00 33, .48 D
ATOM 61δ7 CZ PHE 435 32. 3gg 135.838 60.353 1. 00 33, .48 D
ATOM 61δδ C PHE 435 3δ . lδ6 136. gβδ 63.049 1. 00 33. .48 D
ATOM 61δ9 O PHE 435 38.653 136.516 64.093 1. 00 33. ,48 D
ATOM 6igo N GLU 436 38.624 138.071 62.473 1. 00 33. ,48 D
ATOM 6igι CA GLU 436 3g .68δ 138.826 63.065 1. 00 33. ,48 D
ATOM 6ig2 CB GLU 436 40.194 13g.855 62.068 1. 00 33. ,48 D
ATOM 6ig3 CG GLU 436 39.132 140.796 61.563 1. 00 33. ,48 D
ATOM 6ig4 CD GLU 436 39.6gi 141.830 60.616 1. 00 33. .48 D
ATOM 6i 5 OEl GLU 436 40.675 142.507 60.995 1. 00 33. .48 D
ATOM 6ig6 OE2 GLU 436 3g . l42 141.967 59.499 1. 00 33. .48 D
ATOM 6ig7 C GLU 436 39.121 13g.50δ 64.310 1. 00 33. ,48 D
ATOM 6ig8 O GLU 436 37.9δ0 13g.947 64.32δ 1. 00 33. .48 D ATOM 6igg N PHE 437 39. gig 13g.576 65.363 1.00 33..48 D
ATOM 6200 CA PHE 437 3g.487 140.19δ 66.5g6 1.00 33, .48 D
ATOM 6201 CB PHE 437 40.431139.841 67.731 1.00 33, .48 D
ATOM 6202 CG PHE 437 40.0δg 140.481 6g.033 1.00 33, .48 D
ATOM 6203 CDl PHE 437 41.040 141.188 69.736 1.00 33, .48 D
ATOM 6204 CD2 PHE 437 3δ.844 140.311 69.5gg 1.00 33, .48 D
ATOM 6205 CEl PHE 437 40.754 141.705 70.g86 1.00 33, .48 D
ATOM 6206 CE2 PHE 437 38.561 140.827 70.846 1.00 33, .48 D
ATOM 6207 CZ PHE 437 3g.51δ 141.520 71.536 1.00 33, .48 D
ATOM 620δ C PHE 437 3g.515 141.684 66.38g 1.00 33, .48 D
ATOM 620g 0 PHE 437 40.443 142.216 65.7δ5 1.00 33, .48 D
ATOM 6210 N MET 438 38.473 142.336 66.888 1.00 33, .48 D
ATOM 6211 CA MET 438 38.316 143.772 66.831 1.00 33, .48 D
ATOM 6212 CB MET 438 36.ggo 144.122 66.168 1.00 33, .48 D
ATOM 6213 CG MET 438 36.941 143.75g 64.6g6 1.00 33, .48 D
ATOM 6214 SD MET 438 38.121 144.6g6 63.6δl 1.00 33, .48 D
ATOM 6215 CE MET 438 37.534 146.275 63.897 1.00 33, .48 D
ATOM 6216 C MET 438 3δ.341 144.185 68.297 1.00 33, .48 D
ATOM 6217 0 MET 438 37.330 144.179 68.9g2 1.00 33, .48 D
ATOM 621δ N GLU 439 39.530 144.539 6δ.750 1.00 33, .48 D
ATOM 62ig CA GLU 439 39.773 144.900 70.12g 1.00 33, .48 D
ATOM 6220 CB GLU 439 41.228 145.280 70.280 1.00 33, .48 D
ATOM 6221 CG GLU 439 41.63g 146.406 6g.3 g 1.00 33, .48 D
ATOM 6222 CD GLU 439 43.0δ3 146.757 6g.613 1.00 33, .48 D
ATOM 6223 OEl GLU 439 43.446 147.017 70.781 1.00 33, .48 D
ATOM 6224 OE2 GLU 439 43.δ51146.765 6δ.621 1.00 33, .48 D
ATOM 6225 C GLU 439 3δ.g40 145.951 70.δ35 1.00 33, .48 D
ATOM 6226 0 GLU 439 3δ.gδi 146.019 72.062 1.00 33, ,48 D
ATOM 6227 N HIS 440 38.ig2 146.771 70.103 1.00 33, ,48 D
ATOM 6228 CA HIS 440 37.407 147. δ14 70.757 1.00 33, .48 D
ATOM 622g CB HIS 440 37.677 149.151 70.0g4 1.00 33, .48 D
ATOM 6230 CG HIS 440 3g.043 149.675 70.380 1.00 33, .48 D
ATOM 6231 CD2 HIS 440 40.100 149.905 6g.56g 1.00 33, .48 D
ATOM 6232 NDl HIS 440 3g.471 149.956 71.657 1.00 33, .48 D
ATOM 6233 CEl HIS 440 40.735 150.334 71.622 1.00 33, .48 D
ATOM 6234 NE2 HIS 440 41.141 150.311 70.366 1.00 33, .48 D
ATOM 6235 C HIS 440 35. gig 147.592 70.875 l.OO 33, .48 D
ATOM 6236 0 HIS 440 35.259 148.302 71.614 l.OO 33, .48 D
ATOM 6237 N GLY 441 35.391146.608 70.162 l.OO 33, .48 D
ATOM 6238 CA GLY 441 33.g74 146.327 70.252 1.00 33, .48 D
ATOM 623g C GLY 441 33.157 147.032 εg.igδ l.OO 33, .48 D
ATOM 6240 0 GLY 441 33.684 147.507 6δ.ig7 l.OO 33, .48 D
ATOM 6241 N CYS 442 31.855 147. ogg 6g.426 l.OO 33, .48 D
ATOM 6242 CA CYS 442 30.g61 147.752 68.484 l.OO 33, .48 D ATOM 6243 CB CYS 442 29.528 147.407 6δ.δl9 1.00 33.,48 D
ATOM 6244 SG CYS 442 29.355 145.727 69.337 1.00 33. ,48 D
ATOM 6245 C CYS 442 31.118 149.258 68.513 1.00 33. ,48 D
ATOM 6246 0 CYS 442 31.303 149.848 6g .571 1.00 33. ,48 D
ATOM 6247 N LEU 443 31.020 149.875 67.343 1.00 33. ,48 D
ATOM 6248 CA LEU 443 31.147 151.314 67.234 1.00 33. ,48 D
ATOM 6249 CB LEU 443 30.852 151.743 65.807 1.00 33. ,48 D
ATOM 6250 CG LEU 443 31.032 153.206 65.442 1.00 33. ,48 D
ATOM 6251 CDl LEU 443 32.406 153.731 65.843 1.00 33. ,48 D
ATOM 6252 CD2 LEU 443 30.822 153.300 63.g55 1.00 33. ,48 D
ATOM 6253 C LEU 443 30.187 151.990 68.201 1.00 33. ,48 D
ATOM 6254 0 LEU 443 30.560 152.921 68.905 1.00 33, ,48 D
ATOM 6255 N SER 444 2δ.956 151.503 68.253 1.00 33. ,48 D
ATOM 6256 CA SER 444 27.964 152.oeg 69.146 1.00 33. ,48 D
ATOM 6257 CB SER 444 26.674 151.260 69.100 1.00 33. .48 D
ATOM 6258 OG SER 444 26.905 149.901 69.42g 1.00 33. .48 D
ATOM 6259 C SER 444 2δ.441 152.137 70.580 1.00 33. ,48 D
ATOM 6260 0 SER 444 28.234 153.142 71.247 1.00 33, .48 D
ATOM 6261 N ASP 445 29.080 151.081 71.069 1.00 33, .48 D
ATOM 6262 CA ASP 445 29.537 151.101 72.451 1.00 33, .48 D
ATOM 6263 CB ASP 445 29.745 149.68g 72.9gi 1.00 33, .48 D
ATOM 6264 CG ASP 445 28.732 148.692 72.466 1.00 33, .48 D
ATOM 6265 ODl ASP 445 27.526 149.030 72.424 1.00 33, .48 D
ATOM 6266 OD2 ASP 445 29.151147.559 72. Ill 1.00 33, .48 D
ATOM 6267 C ASP 445 30.834 151.864 72.606 1.00 33, .48 D
ATOM 6268 0 ASP 445 31.097 152.440 73.641 1.00 33, .48 D
ATOM 6269 N TYR 446 31.661 151.852 71.581 1.00 33, .48 D
ATOM 6270 CA TYR 446 32.919 152.556 71.673 1.00 33, .48 D
ATOM 6271 CB TYR 446 33.769 152.30δ 70.426 1.00 33, .48 D
ATOM 6272 CG TYR 446 35.167 152. δδ3 70.4gg 1.00 33, .48 D
ATOM 6273 CDl TYR 446 36.016 152.559 71.542 1.00 33, .48 D
ATOM 6274 CEl TYR 446 37.2gg 153.066 71.5g4 1.00 33, .48 D
ATOM 6275 CD2 TYR 446 35.643 153.736 6g.506 1.00 33, .48 D
ATOM 6276 CE2 TYR 446 36.g23 154.24δ 6g.547 1.00 33, .48 D
ATOM 6277 CZ TYR 446 37.748 153. gog 70.5g2 1.00 33 .48 D
ATOM 6278 OH TYR 446 3g.035 154.3g4 70.633 1.00 33, .48 D
ATOM 6279 C TYR 446 32.582 154.022 71.803 1.00 33, .48 D
ATOM 6280 0 TYR 446 33.133 154.717 72.653 1.00 33 .48 D
ATOM 6281 N LEU 447 31.661 154.487 70.g63 1.00 33 .48 D
ATOM 62δ2 CA LEU 447 31.232 155.8δ2 70.g83 1.00 33, .48 D
ATOM 62δ3 CB LEU 447 30.119 156. o β 6g . g56 1.00 33 .48 D
ATOM 6284 CG LEU 447 30.521 156.012 68.485 1.00 33, .48 D
ATOM 6285 CDl LEU 447 29.303 155. g45 67.627 1.00 33, .48 D
ATOM 6286 CD2 LEU 447 31.361 157.201 68. Ill 1.00 33, .48 D ATOM 6287 C LEU 447 30.735 156.241 72.3δ2 1.0033.48 D
ATOM 6288 O LEU 447 31.346 157.034 73.0g2 1.0033.48 D
ATOM 628g N ARG 448 2g.624 155.631 72.766 1.0033.48 D
ATOM 62go CA ARG 448 2g.025 155.851 74.06δ 1.0033.4δ D
ATOM 62gi CB ARG 448 28.027 154.734 74.3δl 1.00 33.4δ D
ATOM 62g2 CG ARG 448 26.656 154. gg6 73.835 1.00 33.4δ D
ATOM 62g3 CD ARG 448 25.gi6 153.741 73.456 1.00 33.48 D
ATOM 62g4 NE ARG 448 25.052 154.041 72.321 1.00 33.48 D
ATOM 62 5 CZ ARG 448 24.387 153.140 71.615 1.00 33.48 D
ATOM 62g6 NHl ARG 448 24.466 151.856 71.922 1.00 33.48 D
ATOM 62 7 NH2 ARG 448 23.66δ 153.527 70.577 1.00 33.48 D
ATOM 62gδ C ARG 448 30.043 155.925 75.184 1.00 33.48 D
ATOM 62gg O ARG 448 2g.g85 156.832 76.014 1.00 33.48 D
ATOM 6300 N THR 449 30.g75 154.975 75.19g 1.00 33.48 D
ATOM 6301 CA THR 44 31.985 154.897 76.242 1.00 33.48 D
ATOM 6302 CB THR 44g 32.651153.525 76.250 1.0033.48 D
ATOM 6303 OGl THR 44g 31.656 152.521 76.041 1.00 33.48 D
ATOM 6304 CG2 THR 44g 33.300 153.258 77.5g4 1.00 33.48 D
ATOM 6305 C THR 44g 33.069 155.94g 76.150 1.0033.4δ D
ATOM 6306 O THR 449 33.428 156.567 77.144 1.0033.48 D
ATOM 6307 N GLN 450 33.5gg 156.168 74.g61 1.00 33.48 D
ATOM 630δ CA GLN 450 34.658 157.157 74.805 1.0033.48 D
ATOM 630g CB GLN 450 35.634 156.668 73.722 1.00 33.48 D
ATOM 6310 CG GLN 450 37.074 156.803 74.105 1.00 33.48 D
ATOM 6311 CD GLN 450 37.328 156.314 75.509 1.00 33.48 D
ATOM 6312 OEl GLN 450 38.181156.850 76.218 1.00 33.4δ D
ATOM 6313 NE2 GLN 450 36.5g4 155.2g2 75.923 1.00 33.4δ D
ATOM 6314 C GLN 450 34.0g2 158.538 74.453 1.00 33.4δ D
ATOM 6315 O GLN 450 34.737 159.330 73.774 1.00 33.4δ D
ATOM 6316 N ARG 451 32.895 158.835 74.g42 1.00 33.4δ D
ATOM 6317 CA ARG 451 32.243 160.108 74.633 1.00 33.4δ D
ATOM 631δ CB ARG 451 30.779 160.066 75.045 1.00 33.48 D
ATOM 63ig CG ARG 451 30.060 161.355 74.756 1.0033.48 D
ATOM 6320 CD ARG 451 28.588 161.211 75.017 1.00 33.48 D
ATOM 6321 NE ARG 451 27.gg7 160.241 74.110 1.00 33.48 D
ATOM 6322 CZ ARG 451 26.817 159.657 74.2g8 1.00 33.48 D
ATOM 6323 NHl ARG 451 26.083 159.942 75.36δ 1.00 33.48 D
ATOM 6324 NH2 ARG 451 26.375 158.769 73.421 1.00 33.48 D
ATOM 6325 C ARG 451 32.δ3δ 161.412 75.160 1.00 33.48 D
ATOM 6326 O ARG 451 33.140161.561 76.336 1.00 33.48 D
ATOM 6327 N GLY 452 32.g76 162.3δ0 74.273 1.00 33.48 D
ATOM 632δ CA GLY 452 33.505 163.64g 74.6gg 1.00 33.4δ D
ATOM 6329 C GLY 452 35.004 163.611 74.δ35 1.00 33.48 D
ATOM 6330 O GLY 452 35.575 164.344 75.642 1.00 33.48 D ATOM 6331 N LEU 453 35.643 162.756 74.048 1.00 33..48 D
ATOM 6332 CA LEU 453 37.093 162.635 74.060 1.00 33, .48 D
ATOM 6333 CB LEU 453 37.507 161.392 74.840 1.00 33, .48 D
ATOM 6334 CG LEU 453 37.038 161.332 76.2g2 1.00 33, ,48 D
ATOM 6335 CDl LEU 453 36.375 160.007 76.570 1.00 33. ,48 D
ATOM 6336 CD2 LEU 453 38.209 161.537 77.206 1.00 33, .48 D
ATOM 6337 C LEU 453 37.551 162.520 72.611 1.00 33, .48 D
ATOM 6338 0 LEU 453 38.749 162.431 72.333 1.00 33, .48 D
ATOM 6339 N PHE 454 36.576 162.506 71.701 1.00 33, .48 D
ATOM 6340 CA PHE 454 36.809 162.411 70.267 1.00 33, .48 D
ATOM 6341 CB PHE 454 35.637 161.755 6g.550 1.00 33, .48 D
ATOM 6342 CG PHE 454 35.44g 160.313 69.855 1.00 33, .48 D
ATOM 6343 CDl PHE 454 36.325 159.367 69.361 1.00 33, .48 D
ATOM 6344 CD2 PHE 454 34.358 lsg.sgi 70.596 1.00 33, .48 D
ATOM 6345 CEl PHE 454 36.117 158.018 69.59g 1.00 33 .48 D
ATOM 6346 CE2 PHE 454 34.138 158.548 70.840 1.00 33, .48 D
ATOM 6347 CZ PHE 454 35.0ig 157.604 70.341 1.00 33, .48 D
ATOM 6348 C PHE 454 36.857 163.825 6g.767 1.00 33, .48 D
ATOM 6349 0 PHE 454 36.2δ3 164.710 70.380 1.00 33 .48 D
ATOM 6350 N ALA 455 37.523 164.02g 68.642 1.00 33 .48 D
ATOM 6351 CA ALA 455 37.600 165.336 68.0ig 1.00 33 .48 D
ATOM 6352 CB ALA 455 3g.040 165.751 67.δ78 1.00 33 .48 D
ATOM 6353 C ALA 455 36.g33 165.166 66.642 1.00 33 .48 D
ATOM 6354 0 ALA 455 36.911164.063 66.103 1.00 33, .48 D
ATOM 6355 N ALA 456 36.3δ2 166.240 66.082 1.00 33, .48 D
ATOM 6356 CA ALA 456 35.701 166.183 64.788 1.00 33, .48 D
ATOM 6357 CB ALA 456 35.519 167.570 64.260 1.00 33 .48 D
ATOM 6358 C ALA 456 36.343 165.316 63.704 1.00 33 .48 D
ATOM 6359 0 ALA 456 35.645 164.578 63.013 1.00 33 .48 D
ATOM 6360 N GLU 457 37.657 165.419 63.532 1.00 33 .48 D
ATOM 6361 CA GLU 457 3δ.343 164.622 62.526 1.00 33 .48 D
ATOM 6362 CB GLU 457 39.δ51164.770 62.624 1.00 33, .48 D
ATOM 6363 CG GLU 457 40.4ig 166.154 62.577 1.00 33 .48 D
ATOM 6364 CD GLU 457 41.942 166.106 62.6gi 1.00 33 .48 D
ATOM 6365 OEl GLU 457 42.447 165.146 63.336 1.00 33 .48 D
ATOM 6366 OE2 GLU 457 42.631167.015 62.154 1.00 33 .48 D
ATOM 6367 C GLU 457 3δ.035 163.154 62.746 1.00 33 .48 D
ATOM 6368 0 GLU 457 37.544 162.486 61.856 1.00 33 .48 D
ATOM 6369 N THR 458 3δ.354 162.650 63.g31 1.00 33 .48 D
ATOM 6370 CA THR 458 38.115 161.248 64.266 1.00 33 .48 D
ATOM 6371 CB THR 458 38.144 161.028 65.7g3 1.00 33 .48 D
ATOM 6372 OGl THR 458 39.4gi 161.133 66.26δ 1.00 33 .48 D
ATOM 6373 CG2 THR 458 37.575 159.661 66.151 1.00 33 .48 D
ATOM 6374 C THR 458 36.779 160.750 63.735 1.00 33 .48 D ATOM 6375 O THR 458 36.715 15g.865 62.8δ6 1.00 33.48 D
ATOM 6376 N LEU 45 35.70g 161.32δ 64.252 1.00 33.48 D
ATOM 6377 CA LEU 45g 34.380 160. g62 63.δ25 1.00 33.48 D
ATOM 6378 CB LEU 45g 33.370161. i7 64.458 1.00 33.48 D
ATOM 637g CG LEU 45 33.08δ 161.6δ5 65.g47 1.00 33.48 D
ATOM 6380 CDl LEU 45g 34.273 161.019 66.604 1.00 33.48 D
ATOM 6381 CD2 LEU 45g 32.758 163. OOδ 66.621 1.00 33.48 D
ATOM 6382 C LEU 45g 34.257 160.97δ 62.2gδ 1.00 33.48 D
ATOM 6383 O LEU 45g 33.736 160.031 61.698 1.00 33.48 D
ATOM 6384 N LEU 460 34.733 162.04δ 61.667 1.00 33.48 D
ATOM 63δ5 CA LEU 460 34.657 162.134 60.216 1.00 33.48 D
ATOM 63δ6 CB LEU 460 35.351163.391 5g.703 1.00 33.4δ D
ATOM 6387 CG LEU 460 35.303 163.654 58.ig4 1.00 33.4δ D
ATOM 638δ CDl LEU 460 33.8g7 163.553 57.63δ 1.00 33.4δ D
ATOM 63δg CD2 LEU 460 35.839 165.02δ 57.954 1.00 33.4δ D
ATOM 63go C LEU 460 35.305 160.912 59.603 1.00 33.4δ D
ATOM 63 ι O LEU 460 34.747 160.279 5δ.70g 1.00 33.48 D
ATOM 63g2 N GLY 461 36.485 160.577 60.104 1.00 33.48 D
ATOM 63g3 CA GLY 461 37.200 159.421 5g.602 1.00 33.4δ D
ATOM 63g4 C GLY 461 36.396 158.154 59.781 1.00 33.48 D
ATOM 63g5 0 GLY 461 36.288 157.336 5δ.872 1.00 33.48 D
ATOM 63g6 N MET 462 35.816 157.gg3 60.959 1.00 33.48 D
ATOM 63g7 CA MET 462 35.030 156.812 61.230 1.00 33.48 D
ATOM 63g CB MET 462 34.441156.881 62.635 1.00 33.48 D
ATOM 6399 CG MET 462 35.477 156. sδ 63.729 1.00 33.48 D
ATOM 6400 SD MET 462 34.719 156. δ43 65.324 1.00 33.48 D
ATOM 6401 CE MET 462 36.122 156.665 66.338 1.00 33.4δ D
ATOM 6402 C MET 462 33.921156.710 60.203 1.00 33.48 D
ATOM 6403 O MET 462 33.395 155.634 59.g47 1.00 33.48 D
ATOM 6404 N CYS 463 33.556 157.833 5g.606 1.00 33.48 D
ATOM 6405 CA CYS 463 32.502 157.7gδ 58.611 1.00 33.48 D
ATOM 6406 CB CYS 463 31.776 159.145 58.553 1.00 33.48 D
ATOM 6407 SG CYS 463 30.535 159.370 5g.880 1.00 33.4δ D
ATOM 6408 C CYS 463 33.055 157.415 57.24δ 1.00 33.4δ D
ATOM 640g 0 CYS 463 32.374 156.765 56.461 1.00 33.4δ D
ATOM 6410 N LEU 464 34.296 157.7gg 56.973 1.00 33.4δ D
ATOM 6411 CA LEU 464 34.910 157.46δ 55.697 1.00 33.4δ D
ATOM 6412 CB LEU 464 36.239 158.194 55.550 1.00 33.4δ D
ATOM 6413 CG LEU 464 36.230 159.207 54.412 1.00 33.48 D
ATOM 6414 CDl LEU 464 37.4g4 160.033 54.457 1.00 33.48 D
ATOM 6415 CD2 LEU 464 36.104 158.486 53.088 1.00 33.48 D
ATOM 6416 C LEU 464 35.116 155. g60 55.581 1.00 33.48 D
ATOM 6417 0 LEU 464 34.850 155.360 54.533 1.00 33.48 D
ATOM 6418 N ASP 465 35.5gθ 155.345 56.657 1.00 33.48 D ATOM 64ig CA ASP 465 35.793 153.913 56.651 1.00 33.48 D
ATOM 6420 CB ASP 465 36.202 153.434 58.030 1.00 33.48 D
ATOM 6421 CG ASP 465 37.576 153.872 58.390 1.00 33.48 D
ATOM 6422 ODl ASP 465 38.077 153.502 59.469 1.00 33.48 D
ATOM 6423 OD2 ASP 465 38.157 154.599 57.571 1.00 33.48 D
ATOM 6424 C ASP 465 34.487 153.259 56.263 1.00 33.48 D
ATOM 6425 0 ASP 465 34.311 152.816 55.128 1.00 33.48 D
ATOM 6426 N VAL 466 33.564 153.223 57.218 1.00 33.4δ D
ATOM 6427 CA VAL 466 32.261152.623 57.004 1.00 33.4δ D
ATOM 6428 CB VAL 466 31.238 153.123 58.024 1.00 33.48 D
ATOM 6429 CGl VAL 466 2g.g72 152.301 57.915 1.00 33.48 D
ATOM 6430 CG2 VAL 466 31.805 153.030 59.414 1.00 33.48 D
ATOM 6431 C VAL 466 31.732 152.933 55.613 1.00 33.48 D
ATOM 6432 0 VAL 466 30.δ7δ 152.212 55.096 1.00 33.48 D
ATOM 6433 N CYS 467 32.238 154.005 55.010 1.00 33.4δ D
ATOM 6434 CA CYS 467 31.807 154.396 53.679 1.00 33.4δ D
ATOM 6435 CB CYS 467 32.015 155.903 53.472 1.00 33.48 D
ATOM 6436 SG CYS 467 31.234 156.638 51.990 1.00 33.48 D
ATOM 6437 C CYS 467 32.622 153.59g 52.677 1.00 33.48 D
ATOM 6438 0 CYS 467 32.060 152. 76 51.777 1.00 33.48 D
ATOM 6439 N GLU 468 33.g43 153.610 52.843 1.00 33.48 D
ATOM 6440 CA GLU 468 34.δ32 152.878 51.942 1.00 33.48 D
ATOM 6441 CB GLU 468 36.25δ 152.852 52.473 1.00 33.48 D
ATOM 6442 CG GLU 468 36.δ6δ 154.210 52.682 1.00 33.48 D
ATOM 6443 CD GLU 468 38.371 154.132 52.892 1.00 33.48 D
ATOM 6444 OEl GLU 468 3δ.gg5 155.193 53.131 1.00 33.48 D
ATOM 6445 OE2 GLU 468 3δ.g26 153.006 52.80g 1.00 33.48 D
ATOM 6446 C GLU 46δ 34.354 151.452 51.816 1.00 33.48 D
ATOM 6447 0 GLU 468 34.08g 150.965 50.723 1.00 33.4δ D
ATOM 6448 N GLY 469 34.265 150.773 52.g47 1.00 33.4δ D
ATOM 6449 CA GLY 469 33.7g7 149.414 52.g08 1.00 33.48 D
ATOM 6450 C GLY 469 32.501 149.411 52.131 1.00 33.48 D
ATOM 6451 0 GLY 469 32.417 148.842 51.048 1.00 33.48 D
ATOM 6452 N MET 470 31.496 150.089 52.675 1.00 33.48 D
ATOM 6453 CA MET 470 30.177 150.171 52.068 1.00 33.48 D
ATOM 6454 CB MET 470 2g.348 151.202 52.804 1.00 33.48 D
ATOM 6455 CG MET 470 27.δgi 150.910 52.735 1.00 33.48 D
ATOM 6456 SD MET 470 27.564 149.279 53.357 1.00 33.48 D
ATOM 6457 CE MET 470 2δ.63g 149.263 54.700 1.00 33.48 D
ATOM 6458 C MET 470 30.176 150.4δ6 50.57g 1.00 33.48 D
ATOM 6459 0 MET 470 2g.2g2 150.046 4g.846 1.00 33.48 D
ATOM 6460 N ALA 471 31.159 151.254 50.127 1.00 33.4δ D
ATOM 6461 CA ALA 471 31.240 151.592 4δ.712 1.00 33.4δ D
ATOM 6462 CB ALA 471 32.330 152.618 4δ.47g 1.00 33.4δ D ATOM 6463 C ALA 471 31.529 150.3ig 47.gi6 1.00 33..48 D
ATOM 6464 O ALA 471 30.982 150.118 46.823 1.00 33. .48 D
ATOM 6465 N TYR 472 32.389 i4g.46g 48.485 1.00 33. .48 D
ATOM 6466 CA TYR 472 32.786 14 . ιg3 47.δδ8 1.00 33. .48 D
ATOM 6467 CB TYR 472 33.g27 147.5g6 48.70g 1.00 33, .48 D
ATOM 6468 CG TYR 472 34.184 146.122 4δ.491 1.00 33, .48 D
ATOM 646g CDl TYR 472 34.671 145.63δ 47.277 1.00 33, .48 D
ATOM 6470 CEl TYR 472 34.g37 144.277 47.105 1.00 33, .48 D
ATOM 6471 CD2 TYR 472 33.g66 145.20δ 49.522 1.00 33, .48 D
ATOM 6472 CE2 TYR 472 34.226 143.853 49.356 1.00 33, .48 D
ATOM 6473 CZ TYR 472 34.710 143.3g 4δ.l52 1.00 33, .48 D
ATOM 6474 OH TYR 472 34.g70 142.061 4δ.016 1.00 33 .48 D
ATOM 6475 C TYR 472 31.617 147.211 47.7δ9 1.00 33 .48 D
ATOM 6476 0 TYR 472 31.404 146.5g4 46.751 1.00 33 .48 D
ATOM 6477 N LEU 473 30.δ50 147.061 4δ.85g 1.00 33 .48 D
ATOM 6478 CA LEU 473 2g.710 146.159 48.7δδ 1.00 33, .48 D
ATOM 647g CB LEU 473 28.861 146.209 so.osg 1.00 33, .48 D
ATOM 6480 CG LEU 473 2g.3g7 145.736 51.398 1.00 33, .48 D
ATOM 6481 CDl LEU 473 30.472 146.685 51.872 1.00 33, .48 D
ATOM 6482 CD2 LEU 473 28.260 145.692 52.397 1.00 33, .48 D
ATOM 6483 C LEU 473 28.837 146.610 47.628 1.00 33, .48 D
ATOM 6484 0 LEU 473 28.104 145.813 47.036 1.00 33, .48 D
ATOM 6485 N GLU 474 28.gi8 147.905 47.326 1.00 33, .48 D
ATOM 6486 CA GLU 474 28.121 148.501 46.264 1.00 33, .48 D
ATOM 6487 CB GLU 474 28.045 150.024 46.441 1.00 33, .48 D
ATOM 6488 CG GLU 474 27.068 150.720 45.478 1.00 33 .48 D
ATOM 648g CD GLU 474 26.g87 152.233 45.686 1.00 33 .48 D
ATOM 64go OEl GLU 474 27.gg3 152.945 45.442 1.00 33 .48 D
ATOM 64gi OE2 GLU 474 25. gog 152.711 46.098 1.00 33, .48 D
ATOM 64g2 C GLU 474 2δ.676 148.157 44.891 1.00 33, .48 D
ATOM 64g3 0 GLU 474 27.g62 147.595 44.063 1.00 33, .48 D
ATOM 64g4 N GLU 475 2g.g44 148.4δ0 44.644 1.00 33, .48 D
ATOM 64 5 CA GLU 475 30.550 148.178 43.349 1.00 33, .48 D
ATOM 64g6 CB GLU 475 32.022 148.611 43.3ig 1.00 33, .48 D
ATOM 64g7 CG GLU 475 32.740 148.339 41.993 1.00 33, .48 D
ATOM 64g8 CD GLU 475 33.7g5 149.415 41.629 1.00 33, .48 D
ATOM 64gg OEl GLU 475 34.5gi 149.813 42.519 1.00 33, .48 D
ATOM 6500 OE2 GLU 475 33.840 149.855 40.446 1.00 33, ,48 D
ATOM 6501 C GLU 475 30.442 146.688 43.102 1.00 33, .48 D
ATOM 6502 0 GLU 475 30.565 146.238 41.970 1.00 33, ,48 D
ATOM 6503 N ALA 476 30.18δ 145.93g 44.178 1.00 33, .48 D
ATOM 6504 CA ALA 476 30.060 144.480 44.141 1.00 33, .48 D
ATOM 6505 CB ALA 476 31.122 143.845 45.046 1.00 33, .48 D
ATOM 6506 C ALA 476 28.666 144.011 44.565 1.00 33, .48 D ATOM 6507 0 ALA 476 28.516143.135 45.41δ 1.00 33.48 D
ATOM 6508 N CYS 477 27.655 144.609 43.953 1.00 33.48 D
ATOM 650g CA CYS 477 26.251144.2g4 44.211 1.00 33.48 D
ATOM 6510 CB CYS 477 25.6g8 143.517 43.029 1.00 33.48 D
ATOM 6511 SG CYS 477 25.456 144.600 41.629 1.00 33.48 D
ATOM 6512 C CYS 477 25.755 143.619 45.490 1.00 33.48 D
ATOM 6513 0 CYS 477 24.877 142.769 45.421 1.00 33.48 D
ATOM 6514 N VAL 478 26.265 144.004 46.654 1.00 33.48 D
ATOM 6515 CA VAL 478 25.7δ3 143.395 47.δδ8 1.00 33.48 D
ATOM 6516 CB VAL 478 26.g31 142.836 48.721 1.00 33.48 D
ATOM 6517 CGl VAL 478 26.3δ3 142.046 49.8δl 1.00 33.48 D
ATOM 6518 CG2 VAL 478 27.δ03 141.960 47.δ54 1.00 33.48 D
ATOM 65ig C VAL 478 25.022 144.419 4δ.714 1.00 33.48 D
ATOM 6520 0 VAL 478 25.413 145.574 4δ.7g8 1.00 33.48 D
ATOM 6521 N ILE 47 23.g30 143. g85 4g.325 1.00 33.48 D
ATOM 6522 CA ILE 47g 23.114 144.878 50.121 1.00 33.48 D
ATOM 6523 CB ILE 47g 21.650 144.855 4g.674 1.00 33.48 D
ATOM 6524 CG2 ILE 479 20.7gg 145.620 50.670 1.00 33.48 D
ATOM 6525 CGl ILE 479 21.513 145.44g 48.276 1.00 33.48 D
ATOM 6526 CDl ILE 479 20.127 145.285 47.714 1.00 33.48 D
ATOM 6527 C ILE 47g 23.107 144.568 51.600 1.00 33.48 D
ATOM 6528 0 ILE 47g 22.525 143.566 52.034 1.00 33.48 D
ATOM 652g N HIS 480 23.745 145.441 52.374 1.00 33.4δ D
ATOM 6530 CA HIS 4δ0 23.76g 145.2δ4 53.814 1.00 33.4δ D
ATOM 6531 CB HIS 4δ0 24.743 146.2δ 5 54.442 1.00 33.4δ D
ATOM 6532 CG HIS 4δ0 25.ig7 145. goo 55.815 1.00 33.4δ D
ATOM 6533 CD2 HIS 4δ0 26.440 145.767 56.33g 1.00 33.4δ D
ATOM 6534 NDl HIS 4δ0 24.31δ 145.580 56.82δ 1.00 33.48 D
ATOM 6535 CEl HIS 4δ0 25.000 145.267 57.gi7 1.00 33.48 D
ATOM 6536 NE2 HIS 4δ0 26.2δg 145.372 57.647 1.00 33.48 D
ATOM 6537 C HIS 4δ0 22.341145.650 54.173 1.00 33.48 D
ATOM 6538 0 HIS 480 21.902 146.755 53.δg7 1.00 33.4δ D
ATOM 653g N ARG 481 21.592 144.725 54.748 1.00 33.4δ D
ATOM 6540 CA ARG 481 20.213 145.036 55.100 1.00 33.4δ D
ATOM 6541 CB ARG 481 19.316 143. δog 54.876 1.00 33.4δ D
ATOM 6542 CG ARG 481 18.938 143.577 53.411 1.00 33.48 D
ATOM 6543 CD ARG 481 17.98δ 142.377 53.206 1.00 33.48 D
ATOM 6544 NE ARG 481 17.0g2 142.121 54.344 1.00 33.48 D
ATOM 6545 CZ ARG 481 15.δg3 141.527 54.255 1.00 33.48 D
ATOM 6546 NHl ARG 481 15.419 141.129 53.075 1.00 33.48 D
ATOM 6547 NH2 ARG 481 15.171 141.298 55.356 1.00 33.48 D
ATOM 6548 C ARG 481 20.097 145.495 56.546 1.00 33.48 D
ATOM 654g 0 ARG 481 19.047 145.331 57.167 1.00 33.48 D
ATOM 6550 N ASP 482 21.156 146.092 57. ogo 1.00 33.48 D ATOM 6551 CA ASP 482 21.084 146.505 58.485 1.00 33..48 p
ATOM 6552 CB ASP 482 2o.ggi 145.254 5g.356 1.00 33. .48 D
ATOM 6553 CG ASP 482 20.424145.528 60.725 1.00 33, .48 D
ATOM 6554 ODl ASP 482 20.447 144. sgo 61.557 1.00 33, .48 D
ATOM 6555 OD2 ASP 482 lg.gso 146.664 60.g68 1.00 33, .48 D
ATOM 6556 C ASP 482 22.232 147.371 58.g77 1.00 33, .48 D
ATOM 6557 O ASP 482 22.809 147.0δ7 60.011 1.00 33, .48 D
ATOM 6558 N LEU 4δ3 22.566 148.427 5δ.24δ 1.00 33, .48 D
ATOM 655g CA LEU 4δ3 23.639 14g.304 5δ.6δ3 1.00 33, .48 D
ATOM 6560 CB LEU 4δ3 23.964 150.344 57.623 1.00 33, .48 D
ATOM 6561 CG LEU 483 25.311150.133 56.g52 1.00 33, .48 D
ATOM 6562 CDl LEU 483 25.622 151.315 56.071 1.00 33, .48 D
ATOM 6563 CD2 LEU 483 26.381 149.971 58.001 1.00 33, .48 D
ATOM 6564 C LEU 483 23.241 150.012 5g.g67 1.00 33, .48 D
ATOM 6565 O LEU 483 22.072 150.269 60.212 1.00 33, .48 D
ATOM 6566 N ALA 484 24.238 150.310 60.785 1.00 33, .48 D
ATOM 6567 CA ALA 484 24.060 150. gδo 62.061 1.00 33, .48 D
ATOM 6568 CB ALA 484 23.026 150.251 62.gi6 1.00 33, .48 D
ATOM 6569 C ALA 484 25.435 150. g2δ 62.724 1.00 33, .48 D
ATOM 6570 O ALA 484 26.276 150.107 62.352 1.00 33, .48 D
ATOM 6571 N ALA 485 25.658 151. δll 63.6gθ 1.00 33, .48 D
ATOM 6572 CA ALA 485 26.914 151.868 64.3g6 1.00 33, .48 D
ATOM 6573 CB ALA 485 26.934 153. ogo 65.262 1.00 33, .48 D
ATOM 6574 C ALA 485 27.136 150.616 65.242 1.00 33, .48 D
ATOM 6575 O ALA 485 2δ.263 150.280 65.578 1.00 33, .48 D
ATOM 6576 N ARG 486 26.069 149.915 65.5gδ 1.00 33, .48 D
ATOM 6577 CA ARG 486 26.22g 148.720 66.413 1.00 33 .48 D
ATOM 6578 CB ARG 486 24.8g6 148.315 67.0ig 1.00 33 .48 D
ATOM 6579 CG ARG 486 23.gi6 147.836 65.g71 1.00 33, .48 D
ATOM 6580 CD ARG 486 22.471147.9ig 66.436 1.00 33, .48 D
ATOM 6581 NE ARG 486 21.573 147. gδo 65.2δ4 1.00 33, .48 D
ATOM 6582 CZ ARG 4δ6 20.356 148.515 65.2g7 1.00 33, .48 D
ATOM 6583 NHl ARG 4δ6 ig.872 14g.045 66.412 1.00 33, .48 D
ATOM 6584 NH2 ARG 4δ6 ig.62δ 148.516 64.185 1.00 33, .48 D
ATOM 6585 C ARG 4δ6 26.755 147.583 65.541 1.00 33, .48 D
ATOM 6586 O ARG 486 27.470 146.6g4 66.018 1.00 33, .48 D
ATOM 6587 N ASN 4δ7 26.402 147.604 64.260 1.00 33, .48 D
ATOM 658δ CA ASN 487 26.856 146.560 63.358 1.00 33, .48 D
ATOM 65δ9 CB ASN 487 25.83g 146.339 62.244 1.00 33 .48 D
ATOM 65go CG ASN 487 24.484 145.934 62.775 1.00 33 .48 D
ATOM 65gi ODl ASN 487 24.378 145.059 63.620 1.00 33 .48 D
ATOM 65g2 ND2 ASN 487 23.440 146.568 62.276 1.00 33 .48 D
ATOM 65g3 C ASN 487 28.211146. go6 62.778 1.00 33 .48 D
ATOM 65g4 0 ASN 487 28.537 146.535 61.666 1.00 33 .48 D ATOM 65g5 N CYS 48δ 29.003 147.627 63.550 1.00 33.48 D
ATOM 65g6 CA CYS 4δδ 30.334 148.001 63.124 1.00 33.48 D
ATOM 65g7 CB CYS 4δδ 30.393 149.492 62.δ05 1.00 33.48 D
ATOM 65g SG CYS 4δδ 2g.631 i4g.g4g 61.255 1.00 33.48 D
ATOM 65gg C CYS 488 31.270 147.703 64.274 1.00 33.48 D
ATOM 6600 O CYS 48δ 30.δδg 147. δ74 65.426 1.00 33.4δ D
ATOM 6601 N LEU 4δg 32.4δ2 147.243 63.97δ 1.00 33.4δ D
ATOM 6602 CA LEU 4δ 33.451 146. g74 65.034 1.00 33.4δ D
ATOM 6603 CB LEU 4δ9 34.025 145.567 64.g07 1.00 33.4δ D
ATOM 6604 CG LEU 4δ9 33.212 144.373 65.3g2 1.00 33.4δ D
ATOM 6605 CDl LEU 4δg 32.651 144.665 66.75δ 1.00 33.4δ D
ATOM 6606 CD2 LEU 48g 32.115 144.088 64.438 1.00 33.48 D
ATOM 6607 C LEU 48g 34.5δ7 147. δ7 64.g55 1.00 33.48 D
ATOM 660δ O LEU 48g 34.781 148.63g 63.g34 1.00 33.4δ D
ATOM 660g N VAL 4go 35.334 148.124 66.03g 1.00 33.4δ D
ATOM 6610 CA VAL 4go 36.453 149.045 66.056 1.00 33.4δ D
ATOM 6611 CB VAL 4go 36.316 150.073 67.202 1.00 33.4δ D
ATOM 6612 CGl VAL 4go 37.515 151.017 67.214 1.00 33.4δ D
ATOM 6613 CG2 VAL 4go 35.042 150. δ6δ 67.02g 1.00 33.48 D
ATOM 6614 C VAL 4go 37.74g 14δ.259 66.234 1.00 33.48 D
ATOM 6615 O VAL 4go 37.866 147.467 67.158 1.00 33.48 D
ATOM 6616 N GLY 491 38.717 148.482 65.350 1.00 33.48 D
ATOM 6617 CA GLY 491 3g.gδθ 147.767 65.445 1.00 33.48 D
ATOM 661δ C GLY 491 41.209 148.608 65.776 1.00 33.4δ D
ATOM 66ig O GLY 491 41.098 14g.672 66.383 1.00 33.4δ D
ATOM 6620 N GLU 42 42.3δ6 148.124 65.372 1.00 33.4δ D
ATOM 6621 CA GLU 4g2 43.642 148.819 65.633 1.00 33.4δ D
ATOM 6622 CB GLU 492 44.δig 148.025 65.042 1.00 33.4δ D
ATOM 6623 CG GLU 492 46.1δ6 148.736 65.145 1.00 33.4δ D
ATOM 6624 CD GLU 492 .47.321 147. δ36 65.67g 1.00 33.4δ D
ATOM 6625 OEl GLU 4g2 4δ.4δ4 148.316 65.753 1.00 33.48 D
ATOM 6626 OE2 GLU 4g2 47.048 146.658 66.031 1.00 33.48 D
ATOM 6627 C GLU 4g2 43.628 150.249 65.0g5 1.00 33.48 D
ATOM 6628 O GLU 4g2 43.280 150.498 63. g44 1.00 33.48 D
ATOM 662g N ASN 4g3 44.007 151.184 65.g57 1.00 33.48 D
ATOM 6630 CA ASN 43 44.032 152.602 65.614 1.00 33.48 D
ATOM 6631 CB ASN 43 44.8gi 152.824 64.375 1.00 33.48 D
ATOM 6632 CG ASN 4g3 46.36g 152.651 64.657 1.00 33.48 D
ATOM 6633 ODl ASN 4g3 47.ιgo 152.623 63.730 1.00 33.48 D
ATOM 6634 ND2 ASN 4g3 46.725 152.543 65.g41 1.00 33.4δ D
ATOM 6635 C ASN 4g3 42.631 153.160 65.380 1.00 33.4δ D
ATOM 6636 O ASN 4g3 42.43δ 154.065 64.582 1.00 33.4δ D
ATOM 6637 N GLN 4g4 41.650 152.619 66.081 1.00 33.48 D
ATOM 6638 CA GLN 4g4 40.2g7 153.0δ7 65.gi6 1.00 33.48 D ATOM 663g CB GLN 4g4 40.202 154.553 66.313 1.00 33.48 D
ATOM 6640 CG GLN 494 40.361154. 25 67.7gi 1.00 33.48 D
ATOM 6641 CD GLN 494 40.054 156.271 68.123 1.00 33.48 D
ATOM 6642 OEl GLN 44 40.642 157.191 67.54g 1.00 33.48 D
ATOM 6643 NE2 GLN 44 3g.l27 156.4δ3 6g.051 1.00 33.48 D
ATOM 6644 C GLN 4g4 3g.7gg 152. g23 64.484 1.00 33.48 D
ATOM 6645 O GLN 4g4 3g.l06153.787 63.g62 1.00 33.48 D
ATOM 6646 N VAL 4g5 40.155 151. δ23 63.δ37 1.00 33.48 D
ATOM 6647 CA VAL 4g5 3g.6δ8 151.596 62.477 1.00 33.4δ D
ATOM 664δ CB VAL 4g5 40.561 150.567 61.725 1.00 33.4δ D
ATOM 6649 CGl VAL 4g5 39.897 150.166 60.434 1.00 33.4δ D
ATOM 6650 CG2 VAL 4g5 41.922 151.168 61.420 1.00 33.4δ D
ATOM 6651 C VAL 4g5 38.285 151.048 62.605 1.00 33.4δ D
ATOM 6652 O VAL 4g5 37.977 150.327 63.553 1.00 33.4δ D
ATOM 6653 N ILE 4g6 37.434 151.393 61.650 1.00 33.48 D
ATOM 6654 CA ILE 4g6 36.062 150.936 61.669 1.00 33.48 D
ATOM 6655 CB ILE 4g6 35.075 152.117 61.498 1.00 33.48 D
ATOM 6656 CG2 ILE 4g6 33.65g 151.639 61.725 1.00 33.48 D
ATOM 6657 CGl ILE 4g6 35.417 153.246 62.474 1.00 33.4δ D
ATOM 665δ CDl ILE 4g6 35.402 152.838 63.9ig 1.00 33.4δ D
ATOM 6659 C ILE 4g6 35.855 149. g74 60.527 1.00 33.4δ D
ATOM 6660 O ILE 4g6 36.213 150.262 5 .3g7 1.00 33.4δ D
ATOM 6661 N LYS 4g7 35.282 148.822 60.821 1.00 33.4δ D
ATOM 6662 CA LYS 4g7 35.017 147.847 5g.781 1.00 33.4δ D
ATOM 6663 CB LYS 4g7 35.g5g 146.648 5 .g32 1.00 33.4δ D
ATOM 6664 CG LYS 4g7 37.445 147.019 59.δ54 1.00 33.4δ D
ATOM 6665 CD LYS 4g7 38.347 145.7g6 59.δ47 1.00 33.4δ D
ATOM 6666 CE LYS 4g7 3g.δ04 146.201 59.69g 1.00 33.4δ D
ATOM 6667 NZ LYS 4g7 40.73δ 145.043 5g.540 1.00 33.4δ D
ATOM 666δ C LYS 4g7 33.561 147.419 5g.δg2 1.00 33.4δ D
ATOM 6669 O LYS 4g7 33.006 147.338 6θ.gδ4 1.00 33.4δ D
ATOM 6670 N VAL 4g8 32.g31 147.162 58.760 1.00 33.4δ D
ATOM 6671 CA VAL 4gδ 31.532 146.770 58.774 1.00 33.4δ D
ATOM 6672 CB VAL 4gδ 30.δ70 147.017 57.40g 1.00 33.48 D
ATOM 6673 CGl VAL 4gδ 2g.444 146.530 57.435 1.00 33.48 D
ATOM 6674 CG2 VAL 4gδ 30.925 148.48δ 57.063 1.00 33.4δ D
ATOM 6675 C VAL 4gδ 31.392 145.2g7 sg.ogi 1.00 33.4δ D
ATOM 6676 O VAL 4gδ 31.δ96 144.452 58.353 1.00 33.4δ D
ATOM 6677 N SER 4gg 30.720 144. g62 60.181 1.00 33.4δ D
ATOM 6678 CA SER 4gg 30.54g 143.555 60.47g 1.00 33.4δ D
ATOM 667g CB SER 4gg 30.633 143.312 61.974 1.00 33.4δ D
ATOM 6680 OG SER 4gg 2g.722 144.129 62.670 1.00 33.4δ D
ATOM 6681 C SER 4gg 2g.206 143.0δ7 59.963 1.00 33.4δ D
ATOM 6682 O SER 4gg 2δ.564 143.776 59.177 1.00 33.4δ D ATOM 66δ3 N ASP 500 28.794 141.909 60.422 1.00 33.48 D
ATOM 66δ4 CA ASP 500 27.516 141.293 60.044 1.00 33.48 D
ATOM 66δ5 CB ASP 500 26.437 142.356 59.δ25 1.00 33.4δ D
ATOM 6686 CG ASP 500 26.060 143.073 61.104 1.00 33.4δ D
ATOM 6687 ODl ASP 500 26.98g 143.513 61.828 1.00 33.4δ D
ATOM 66δδ OD2 ASP 500 24.834 143.197 61.378 1.00 33.4δ D
ATOM 66δg C ASP 500 27.604 140.435 5δ.797 1.00 33.4δ D
ATOM 6690 O ASP 500 28.446 139.540 5δ.680 1.00 33.48 D
ATOM 6691 N PHE 501 26.7ig 140.728 57.857 1.00 33.48 D
ATOM 6692 CA PHE 501 26.666 139. gε 56.622 1.00 33.4δ D
ATOM 6693 CB PHE 501 28.066 139.773 56.048 1.00 33.4δ D
ATOM 6694 CG PHE 501 28.873 141.030 55.g81 1.00 33.4δ D
ATOM 6695 CDl PHE 501 30.207 140. gg2 55.568 1.00 33.4δ D
ATOM 6696 CD2 PHE 501 28.314 142.243 56.340 1.00 33.48 D
ATOM 6697 CEl PHE 501 3o.g7g 142.142 55.516 1.00 33.48 D
ATOM 669δ CE2 PHE 501 2g.068 143.401 56.2g5 1.00 33.48 D
ATOM 669g CZ PHE 501 30.410 143.354 55.8δl 1.00 33.4δ D
ATOM 6700 C PHE 501 26.0g4 138.617 57.032 1.00 33.4δ D
ATOM 6701 O PHE 501 25.815 137.75g 56.1δ4 1.00 33.48 D
ATOM 6702 N GLY 502 25.g26 138.447 5δ.345 1.00 33.48 D
ATOM 6703 CA GLY 502 25.389 137.213 5δ.δ86 1.00 33.48 D
ATOM 6704 C GLY 502 23.873 137.155 58.g41 1.00 33.48 D
ATOM 6705 O GLY 502 23.290 136.64g 5g.gi3 1.00 33.48 D
ATOM 6706 N PRO 521 14.244 147.236 61.733 1.00 33.4δ D
ATOM 6707 CD PRO 521 15.418 146.390 61.450 1.00 33.4δ D
ATOM 6708 CA PRO 521 14.604 148.369 62.600 1.00 33.4δ D
ATOM 670g CB PRO 521 16.075 148.090 62.g26 1.00 33.4δ D
ATOM 6710 CG PRO 521 16.567 147.339 61.704 1.00 33.48 D
ATOM 6711 C PRO 521 14.366 149.711 61.88δ 1.00 33.48 D
ATOM 6712 O PRO 521 15.242 150.232 61.194 1.00 33.4δ D
ATOM 6713 N VAL 522 13.167 150.257 62.092 1.00 33.4δ D
ATOM 6714 CA VAL 522 12.723 151.489 61.445 1.00 33.4δ D
ATOM 6715 CB VAL 522 11.249 151.821 61.800 1.00 33.4δ D
ATOM 6716 CGl VAL 522 10.458 150.538 61.975 1.00 33.48 D
ATOM 6717 CG2 VAL 522 11.185 152.680 63.041 1.00 33.48 D
ATOM 6718 C VAL 522 13.552 152.727 61.699 1.00 33.48 D
ATOM 6719 0 VAL 522 13.647 153.5δ6 60.823 1.00 33.48 D
ATOM 6720 N LYS 523 14.144 152. δ4g 62.880 1.00 33.48 D
ATOM 6721 CA LYS 523 14.948 154.034 63.135 1.00 33.48 D
ATOM 6722 CB LYS 523 15.502 154.015 64.562 1.00 33.48 D
ATOM 6723 CG LYS 523 14.458 154.364 65.626 1.00 33.48 D
ATOM 6724 CD LYS 523 15.109 154.591 66.988 1.00 33.48 D
ATOM 6725 CE LYS 523 14.091 154. gg7 68.055 1.00 33.4δ D
ATOM 6726 NZ LYS 523 14.733 155.539 69.305 1.00 33.4δ D ATOM 6727 C LYS 523 16.080154.150 62.120 1.00 33.48 D
ATOM 6728 O LYS 523 16.652 155.202 61.942 1.00 33.48 D
ATOM 672g N TRP 524 16.386 153.061 61.439 1.00 33.48 D
ATOM 6730 CA TRP 524 17.438 153.057 60.435 1.00 33.4δ D
ATOM 6731 CB TRP 524 iδ.4gg 152.025 60.804 1.00 33.4δ D
ATOM 6732 CG TRP 524 ig.427 152.504 61.837 1.00 33.48 D
ATOM 6733 CD2 TRP 524 ig.25δ 152.400 63.247 1.00 33.48 D
ATOM 6734 CE2 TRP 524 20.350153.04δ 63.845 1.00 33.48 D
ATOM 6735 CE3 TRP 524 iδ.2δδ 151.825 64.064 1.00 33.48 D
ATOM 6736 CDl TRP 524 20.57g 153.185 61.636 1.00 33.48 D
ATOM 6737 NEl TRP 524 21.145 153.518 62.836 1.00 33.48 D
ATOM 6738 CZ2 TRP 524 20.502 153.140 65.220 1.00 33.4δ D
ATOM 673g CZ3 TRP 524 lδ.43δ 151.915 65.438 1.00 33.4δ D
ATOM 6740 CH2 TRP 524 ig.536 152.567 66.000 1.00 33.4δ D
ATOM 6741 C TRP 524 16.864152.725 59.070 1.00 33.48 D
ATOM 6742 O TRP 524 17.562 152.747 58.063 1.00 33.48 D
ATOM 6743 N ALA 525 15.575 152.417 59.053 1.00 33.48 D
ATOM 6744 CA ALA 525 14.88g 152.osg 57.826 1.00 33.48 D
ATOM 6745 CB ALA 525 13.716 151.143 58.147 1.00 33.4δ D
ATOM 6746 C ALA 525 14.403 153.253 57.00δ 1.00 33.48 D
ATOM 6747 O ALA 525 13.777 154.187 57.52g 1.00 33.48 D
ATOM 6748 N SER 526 14.6g6153.20δ 55.715 1.00 33.48 D
ATOM 674g CA SER 526 14.263 154.24g 54.804 1.00 33.48 D
ATOM 6750 CB SER 526 14. ggg 154.148 53.482 1.00 33.48 D
ATOM 6751 OG SER 526 14.461 153.06 52.734 1.00 33.48 D
ATOM 6752 C SER 526 12.7g3 153. g72 54.527 1.00 33.48 D
ATOM 6753 O SER 526 12.22g 152. g77 54.g87 1.00 33.48 D
ATOM 6754 N PRO 527 12.155 154.854 53.75g 1.00 33.48 D
ATOM 6755 CD PRO 527 12.563 156.238 53.461 1.00 33.48 D
ATOM 6756 CA PRO 527 10.745 154.641 53.450 1.00 33.48 D
ATOM 6757 CB PRO 527 10.2g4 156.011 52.g35 1.00 33.48 D
ATOM 6758 CG PRO 527 11.572 156.631 52.407 1.00 33.48 D
ATOM 675g C PRO 527 10.404 153.4δ0 52.499 1.00 33.48 D
ATOM 6760 O PRO 527 g.407 152.798 52.717 1.00 33.48 D
ATOM 6761 N GLU 528 n.igδ 153.230 51.459 1.00 33.4δ D
ATOM 6762 CA GLU 528 10.846 152.122 50.580 1.00 33.4δ D
ATOM 6763 CB GLU 528 11.878 151.902 49.486 1.00 33.48 D
ATOM 6764 CG GLU 528 12.470 153.145 48.919 1.00 33.48 D
ATOM 6765 CD GLU 528 13.652 153.602 49.727 1.00 33.4δ D
ATOM 6766 OEl GLU 528 13.456 154.028 50.δδδ 1.00 33.48 D
ATOM 6767 OE2 GLU 528 14.782 153.523 4g.203 1.00 33.48 D
ATOM 6768 C GLU 528 10.811150.896 51.471 1.00 33.4δ D
ATOM 676g O GLU 528 10.040 149. g54 51.265 1.00 33.4δ D
ATOM 6770 N VAL 52g 11.668 150.921 52.47g 1.00 33.4δ D ATOM 6771 CA VAL 529 11.74114g.830 53.439 1.0033.48 D
ATOM 6772 CB VAL 529 13.113 i4g.85g 54.179 1.00 33 .48 D
ATOM 6773 CGl VAL 529 13.225 148.677 55.125 1.00 33 .48 D
ATOM 6774 CG2 VAL 529 14.260 14g.843 53.157 1.00 33 .48 D
ATOM 6775 C VAL 529 10.5δ7 150.028 54.428 1.00 33 .48 D
ATOM 6776 0 VAL 529 10.066 14g.072 54.984 1.00 33 .48 D
ATOM 6777 N PHE 530 10.193 151.2δδ 54.607 1.00 33 .48 D
ATOM 6778 CA PHE 530 9.10δ 151. εgo 55.503 1.00 33 .48 D
ATOM 677g CB PHE 530 8.540 153.04δ 55.103 1.00 33, .48 D
ATOM 6780 CG PHE 530 g . iii 154.195 55.862 1.00 33, .48 D
ATOM 6781 CDl PHE 530 8. 563 155.462 55.726 1.00 33, .48 D
ATOM 6782 CD2 PHE 530 10. 200 154.017 56.691 1.00 33 .48 D
ATOM 6783 CEl PHE 530 g .086 156.534 56.399 1.00 33 .48 D
ATOM 6784 CE2 PHE 530 10.732 155.081 57.369 1.00 33 .48 D
ATOM 6785 CZ PHE 530 10.170 156.355 57.222 1.00 33 .48 D
ATOM 6786 C PHE 530 7. g33 150.752 55.548 1.00 33, .48 D
ATOM 6787 0 PHE 530 7.706 150.070 56.547 1.00 33, .48 D
ATOM 6788 N SER 531 7.157 150.773 54.465 1.00 33 .48 D
ATOM 678g CA SER 531 5. g64 149.944 54.360 1.00 33 .48 D
ATOM 67go CB SER 531 4. 720 150.814 54.5δ7 1.00 33, .48 D
ATOM 67 i OG SER 531 4.760 151.438 55.877 1.00 33, ,48 D
ATOM 67g2 C SER 531 5. δ72 149. ιgδ 53.020 1.00 33, .48 D
ATOM 67g3 0 SER 531 4.786 148.756 52.616 1.00 33, .48 D
ATOM 6794 N PHE 532 7.017 149.075 52.340 1.00 33, .48 D
ATOM 6795 CA PHE 532 7.120 148.360 51.063 1.00 33, .48 D
ATOM 6796 CB PHE 532 7. 500 149.287 4g.goι 1.00 33, .48 D
ATOM 6797 CG PHE 532 6.468 150.307 4g.55g 1.00 33, .48 D
ATOM 679δ CDl PHE 532 6. 57δ 151.036 48.3δ3 1.00 33, .48 D
ATOM 679g CD2 PHE 532 5 .422 150.583 50.424 1.00 33, .48 D
ATOM 6δ00 CEl PHE 532 5 .65g 152.029 48.080 1.00 33, .48 D
ATOM 6δ01 CE2 PHE 532 4. 508 151.564 50.134 1.00 33, .48 D
ATOM 6802 CZ PHE 532 4.622 152.292 4δ.g63 1.00 33, .48 D
ATOM 6803 C PHE 532 8.222 147.310 51.172 1.00 33, .48 D
ATOM 6804 0 PHE 532 8. 540 146.633 50.186 1.00 33, .48 D
ATOM 6δ05 N SER 533 8.827 147.204 52.355 1.00 33, ,48 D
ATOM 6δ06 CA SER 533 g.δgδ 146.238 52.601 1.00 33, ,48 D
ATOM 6807 CB SER 533 g.303 144.892 53.008 1.00 33, .48 D
ATOM 680δ OG SER 533 δ.687 144.274 51.893 1.00 33, .48 D
ATOM 6δ09 C SER 533 10.807 146.032 51.380 1.00 33, .48 D
ATOM 6810 0 SER 533 11.057 144.902 50.957 1.00 33. ,48 D
ATOM 6811 N ARG 534 11.2g5 147.123 50.δ07 1.00 33. .48 D
ATOM 6812 CA ARG 534 12.178 147.003 49.660 1.00 33. ,48 D
ATOM 6813 CB ARG 534 11.815 148.045 48.608 1.00 33. ,48 D
ATOM 6814 CG ARG 534 i2.3gg 147.765 47.236 1.00 33. ,48 D ATOM 6δl5 CD ARG 534 11.869 148.772 46.248 1.0033..48 D
ATOM 6δl6 NE ARG 534 10.410 148.837 46.283 1.00 33. .48 D
ATOM 6817 CZ ARG 534 9.711149.916 45.g32 1.00 33, .48 D
ATOM 681δ NHl ARG 534 10.34g 151.016 45.517 1.00 33, .48 D
ATOM 6δl9 NH2 ARG 534 8.37g 149.907 46.021 1.00 33, .48 D
ATOM 6820 C ARG 534 13.631147.187 50.106 1.00 33, .48 D
ATOM 6821 O ARG 534 13.δg7 147.542 51.258 1.00 33 .48 D
ATOM 6822 N TYR 535 14.571146.946 4g.200 1.00 33, .48 D
ATOM 6823 CA TYR 535 15.gδ5 147.079 4g.535 1.00 33, .48 D
ATOM 6824 CB TYR 535 16.491145.793 50.205 1.00 33, .48 D
ATOM 6825 CG TYR 535 15.904 145.4δg 51.562 1.00 33 .48 D
ATOM 6826 CDl TYR 535 16.526 145.929 52.718 1.00 33, .48 D
ATOM 6δ27 CEl TYR 535 ls.ggs 145.653 53.g74 1.00 33, .48 D
ATOM 6δ2δ CD2 TYR 535 14.723 144.761 51.689 1.00 33, .48 D
ATOM 6δ29 CE2 TYR 535 14.178 144.4δ2 52.939 1.00 33, .48 D
ATOM 6830 CZ TYR 535 14.823 144.932 54.080 1.00 33, .48 D
ATOM 6831 OH TYR 535 14.308 144.665 55.327 1.00 33, .48 D
ATOM 6832 C TYR 535 16.δ22 147.340 48.285 1.00 33, .48 D
ATOM 6833 O TYR 535 16.791146.552 47.338 1.00 33, .48 D
ATOM 6834 N SER 536 17.566 148.435 48.269 1.00 33, .48 D
ATOM 6835 CA SER 536 lδ.420 148.717 47.126 1.00 33 .48 D
ATOM 6δ36 CB SER 536 17.δ58 149. δ67 46.286 1.00 33, .48 D
ATOM 6837 OG SER 536 18.209 151.140 46.823 1.00 33, .48 D
ATOM 6δ38 C SER 536 19.765 149.123 47.686 1.00 33 .48 D
ATOM 683g O SER 536 ιg.g32 149.221 48.900 1.00 33 .48 D
ATOM 6840 N SER 537 20.737 149.354 46.818 1.00 33, .48 D
ATOM 6841 CA SER 537 22.023 14g.7gδ 47.327 1.00 33, .48 D
ATOM 6842 CB SER 537 23.033 150. oog 46.196 1.00 33 .48 D
ATOM 6843 OG SER 537 24.341 150.164 46.721 1.00 33, .48 D
ATOM 6844 C SER 537 21.68δ 151.136 47.970 1.00 33, .48 D
ATOM 6845 O SER 537 22.22δ 151.500 49.012 1.00 33, .48 D
ATOM 6846 N LYS 538 20.765 151.855 47.341 1.00 33, .48 D
ATOM 6847 CA LYS 538 20.355 153.149 47.852 1.00 33, .48 D
ATOM 6848 CB LYS 538 ιg.3g2 153.850 46.8δl 1.00 33, .48 D
ATOM 684g CG LYS 538 20. iog 154.43g 45.674 1.00 33, .48 D
ATOM 6δ50 CD LYS 538 21.321155.262 46.117 1.00 33, .48 D
ATOM 6δ51 CE LYS 538 22.327 155.490 44.9δ6 1.00 33, .48 D
ATOM 6852 NZ LYS 538 21.772 156.270 43.δ35 1.00 33, .48 D
ATOM 6853 C LYS 538 19.717 153.005 4g.212 1.00 33 .48 D
ATOM 6854 O LYS 538 ιg.g7δ 153.805 50.105 1.00 33, .48 D
ATOM 6855 N SER 539 lδ.δgδ 151.978 4g.3δ3 1.00 33, .48 D
ATOM 6856 CA SER 539 18.242 151.785 50.65g 1.00 33, .48 D
ATOM 6857 CB SER 539 17.53g 150.435 50.713 1.00 33, .48 D
ATOM 6858 OG SER 539 16.7g4150.317 51.918 1.00 33.48 D ATOM 6 5g c SER 539 19.26δ 151.857 51.764 1.00 33..48 D
ATOM 6δ60 0 SER 539 lδ.gso 152.250 52.δδ6 1.00 33, .48 D
ATOM 6861 N ASP 540 20.503 151.481 51.443 1.00 33, .48 D
ATOM 6862 CA ASP 540 21.56g 151.517 52.435 1.00 33. .48 D
ATOM 6863 CB ASP 540 22.663 150.490 52.111 1.00 33. .48 D
ATOM 6864 CG ASP 540 22.228 149.067 52.451 1.00 33. .48 D
ATOM 6865 ODl ASP 540 21.316 148. g32 53.316 1.00 33. .48 D
ATOM 6866 OD2 ASP 540 22.784 14δ.094 51.878 1.00 33, .48 D
ATOM 6δ67 c ASP 540 22.176 152. δ97 52.633 1.00 33, .48 D
ATOM 6δ68 0 ASP 540 22.612 153.220 53.737 1.00 33, .48 D
ATOM 686g N VAL 541 22.203 153.709 51.578 1.00 33, .48 D
ATOM 6870 CA VAL 541 22.734 155.061 51.667 1.00 33, .48 D
ATOM 6871 CB VAL 541 22.437 155.835 50.3δ3 1.00 33 .48 D
ATOM 6δ72 CGl VAL 541 23.227 157.131 50.345 1.00 33, .48 D
ATOM 6δ73 CG2 VAL 541 22.763 154.978 4g.ιg4 1.00 33, .48 D
ATOM 6874 c VAL 541 21.979 155.722 52.811 1.00 33 .48 D
ATOM 6875 0 VAL 541 22.534 156.454 53.633 1.00 33, .48 D
ATOM 6876 N TRP 542 20.690155.436 52.853 1.00 33 .48 D
ATOM 6877 CA TRP 542 ig.836 155.977 53.δδ0 1.00 33, .48 D
ATOM 687δ CB TRP 542 lδ.437 155.3g2 53.746 1.00 33, .48 D
ATOM 687g CG TRP 542 17.481155. sgδ 54.7δl 1.00 33 .48 D
ATOM 6880 CD2 TRP 542 16.4δ0 156. gos 54.595 1.00 33, .48 D
ATOM 68δl CE2 TRP 542 15.7g8 157.045 55.823 1.00 33, .48 D
ATOM 6882 CE3 TRP 542 16.091 157.6gg 53.508 1.00 33, .48 D
ATOM 6883 CDl TRP 542 17.374 155.4δ3 56.0δ3 1.00 33, .48 D
ATOM 6884 NEl TRP 542 16.364 156.166 56.711 1.00 33 .48 D
ATOM 6885 CZ2 TRP 542 14.743 157. gso 55.9g4 1.00 33, .48 D
ATOM 68δ6 CZ3 TRP 542 15.046 15δ.5g4 53.67g 1.00 33, .48 D
ATOM 6δ87 CH2 TRP 542 14.384 158.710 54.gi6 1.00 33 .48 D
ATOM 68δ8 c TRP 542 20.3gi 155.66δ 55.260 1.00 33 .48 D
ATOM 68δg 0 TRP 542 20.716 156.572 56.028 1.00 33 .48 D
ATOM 6δgo N SER 543 20.4g7 154.37g 55.561 1.00 33 .48 D
ATOM 6δgι CA SER 543 2θ.gg2 153. 27 56.843 1.00 33 .48 D
ATOM 68g2 CB SER 543 21.045 152.417 56.852 1.00 33 .48 D
ATOM 68g3 OG SER 543 20.905 151.959 58.176 1.00 33 .48 D
ATOM 6δg4 c SER 543 22.362 154.492 57.172 1.00 33 .48 D
ATOM 68g5 0 SER 543 22.670 154.775 58.322 1.00 33 .48 D
ATOM 68g6 N PHE 544 23.191 154.654 56.155 1.00 33 .48 D
ATOM 6δ 7 CA PHE 544 24.516 155.209 56.359 1.00 33 .48 D
ATOM 6δ δ CB PHE 544 25.271 155.260 55.040 1.00 33 .48 D
ATOM 68gg CG PHE 544 26.57δ 155.96g 55.125 1.00 33 .48 D
ATOM 6goo CDl PHE 544 27.625 155.426 55.838 1.00 33 .48 D
ATOM 6goι CD2 PHE 544 26.758 157.182 54.492 1.00 33 .48 D
ATOM 6g02 CEl PHE 544 28.827 156. Oδl 55.916 1.00 33, .48 D ATOM 6903 CE2 PHE 544 27.950 157.842 54.566 1.00 33.4δ D
ATOM 6904 CZ PHE 544 28.9δδ 157.296 55.276 1.00 33.4δ D
ATOM 6905 C PHE 544 24.373 156.619 56.gi0 1.00 33.4δ D
ATOM 6906 O PHE 544 25.308 157.173 57.476 1.00 33.4δ D
ATOM 6907 N GLY 545 23.ig3 157.202 56.727 1.00 33.4δ D
ATOM 6908 CA GLY 545 22.g46 158.545 57.215 1.00 33.4δ D
ATOM 6gog C GLY 545 22.661 158.514 58.6g5 1.00 33.48 D
ATOM 6gιo O GLY 545 23.175 159.325 5g.452 1.00 33.48 D
ATOM 6911 N VAL 546 21.834 157.574 59.118 1.00 33.4δ D
ATOM 6912 CA VAL 546 21.517 157.469 60.528 1.00 33.4δ D
ATOM 6913 CB VAL 546 20.483 156.360 60.791 1.00 33.4δ D
ATOM 6914 CGl VAL 546 20.024 156.402 62.223 1.00 33.4δ D
ATOM 6915 CG2 VAL 546 19.317 156.532 59.867 1.00 33.4δ D
ATOM 6916 C VAL 546 22.δl6 157.140 61.236 1.00 33.4δ D
ATOM 6917 O VAL 546 23.027 157.536 62.375 1.00 33.48 D
ATOM 6918 N LEU 547 23.6g4 156.424 60.539 1.00 33.48 D
ATOM 69ig CA LEU 547 24.9δ6 156.042 61.099 1.00 33.48 D
ATOM 6g20 CB LEU 547 25.692 155.022 60.192 1.00 33.4δ D
ATOM 6g21 CG LEU 547 26.6δ3 154.070 60.871 1.00 33.4δ D
ATOM 6g22 CDl LEU 547 26.δ23 152.810 60.062 1.00 33.4δ D
ATOM 6g23 CD2 LEU 547 2δ.012 154.756 61.052 1.00 33.4δ D
ATOM 6g24 C LEU 547 25.832 157.291 61.269 1.00 33.4δ D
ATOM 6g25 O LEU 547 26.221 157.600 62.381 1.00 33.4δ D
ATOM 6g26 N MET 54δ 26.108 158.009 60.180 1.00 33.4δ D
ATOM 6g27 CA MET 548 26.883 159.253 60.253 1.00 33.4δ D
ATOM 6g28 CB MET 548 26.778 160.057 58.947 1.00 33.4δ D
ATOM 6g2g CG MET 548 27.690 159.581 57.809 1.00 33.4δ D
ATOM 6g30 SD MET 54δ 27.591 160.575 56.286 1.00 33.48 D
ATOM 6 31 CE MET 548 2δ.829 161.787 56.596 1.00 33.48 D
ATOM 6g32 C MET 548 26.352 160.101 61.402 1.00 33.48 D
ATOM 6g33 O MET 548 27.0g2 160.826 62.050 1.00 33.4δ D
ATOM 6 34 N TRP 549 25.057 159. gδg 61.648 1.00 33.48 D
ATOM 6g35 CA TRP 549 24.407 160.723 62.718 1.00 33.48 D
ATOM 6 36 CB TRP 549 22.886 160.6δ7 62.534 1.00 33.48 D
ATOM 6g37 CG TRP 549 22.161 161.631 63.433 1.00 33.48 D
ATOM 6 38 CD2 TRP 549 21.8g3 161.449 64.824 1.00 33.4δ D
ATOM 6g3 CE2 TRP 549 21.260 162.607 65.283 1.00 33.48 D
ATOM 6g40 CE3 TRP 549 22.133 160.418 65.724 1.00 33.48 D
ATOM 6941 CDl TRP 549 21.683 162.863 63.113 1.00 33.48 D
ATOM 6942 NEl TRP 549 21.139 163.460 64.222 1.00 33.48 D
ATOM 6943 CZ2 TRP 549 20.867 162.760 66.58δ 1.00 33.48 D
ATOM 6944 CZ3 TRP 549 21.739 160.576 67.020 1.00 33.4δ D
ATOM 6945 CH2 TRP 549 21.114 161.735 67.443 1.00 33.4δ D
ATOM 6946 C TRP 549 24.763 160.143 64.0δ5 1.00 33.48 D ATOM 6947 0 TRP 54g 24.δ88 160. δ76 65.054 1.0033,.48 D
ATOM 6948 N GLU 550 24.gi4 158.825 64.171 1.00 33, .48 D
ATOM 6g4g CA GLU 550 25.260158.185 65.439 1.00 33, .48 D
ATOM 6g50 CB GLU 550 25.135 156.665 65.332 1.00 33, .48 D
ATOM 6g51 CG GLU 550 23.825 156.173 64.777 1.00 33, .48 D
ATOM 6g52 CD GLU 550 23.54g 154.718 65.136 1.00 33, .48 D
ATOM 6g53 OEl GLU 550 23.266154.445 66.325 1.00 33, .48 D
ATOM 6 54 OE2 GLU 550 23.618 153.848 64.23δ 1.00 33 .48 D
ATOM 6g55 C GLU 550 26.6gi 158.522 65.δ40 1.00 33, .48 D
ATOM 6g56 0 GLU 550 26.g92 158.753 67.007 1.00 33, .48 D
ATOM 6957 N VAL 551 27.570 158.541 64.δ4g 1.00 33 .48 D
ATOM 6958 CA VAL 551 28.971158.814 65.07g 1.00 33, .48 D
ATOM 695g CB VAL 551 2g.7δl 158.560 63.δl6 1.00 33 .48 D
ATOM 6g60 CGl VAL 551 31.255 15δ.δ50 64. Oδl 1.00 33, .48 D
ATOM 6g61 CG2 VAL 551 2g.565 157.121 63.358 1.00 33 .48 D
ATOM 6g62 C VAL 551 2g.217 160.225 65.551 1.00 33, .48 D
ATOM 6g63 0 VAL 551 2g.δ25 160.434 66.591 1.00 33 .48 D
ATOM 6g64 N PHE 552 2δ.74δ 161.196 64.781 1.00 33, .48 D
ATOM 6g65 CA PHE 552 2δ.gi2 162.594 65.136 1.00 33, .48 D
ATOM 6g66 CB PHE 552 28.458 163.467 63.9δ2 1.00 33, .48 D
ATOM 6g67 CG PHE 552 2g.524 163.706 62.g69 1.00 33, .48 D
ATOM 6g68 CDl PHE 552 30.616164.480 63.279 1.00 33, .48 D
ATOM εgβ CD2 PHE 552 2g.443 163.151 61.719 1.00 33, .48 D
ATOM 6g70 CEl PHE 552 31.599164.696 62.370 1.00 33, .48 D
ATOM 6g71 CE2 PHE 552 30.432 163.365 60.δ00 1.00 33, .48 D
ATOM 6g72 CZ PHE 552 31.510 164.140 61.128 1.00 33, .48 D
ATOM 6g73 C PHE 552 28.161162.947 66.410 1.00 33, .48 D
ATOM 6974 0 PHE 552 28.5δ4 163.837 67.152 1.00 33, .48 D
ATOM 6975 N SER 553 27.04δ 162.257 66.658 1.00 33, .48 D
ATOM 6976 CA SER 553 26.267 162.468 67.867 1.00 33, ,48 D
ATOM 6g77 CB SER 553 24.828 161.988 67.6gθ 1.00 33 .48 D
ATOM 6g78 OG SER 553 24.051162.906 66.g35 1.00 33, .48 D
ATOM 6g7g C SER 553 26.928 161.653 68.g61 1.00 33 .48 D
ATOM 6g80 0 SER 553 26.538 161.703 70.1ig 1.00 33, .48 D
ATOM 69δl N GLU 554 27.935 160.885 68.572 1.00 33, .48 D
ATOM 6982 CA GLU 554 28.6δ0 160.048 6g.4g6 1.00 33, .48 D
ATOM 6983 CB GLU 554 29.400160.902 70.546 1.00 33, .48 D
ATOM 6984 CG GLU 554 30.ig4 162.067 δg.gδo 1.00 33, .48 D
ATOM 6985 CD GLU 554 30.800162.925 71.064 1.00 33, .48 D
ATOM 6986 OEl GLU 554 31.g53 162.670 71.468 1.00 33, .48 D
ATOM 6g87 OE2 GLU 554 30.108 163. δ54 71.530 1.00 33, .48 D
ATOM 6 88 C GLU 554 27.7δ0159.051 70.ig7 1.00 33, .48 D
ATOM εgδ 0 GLU 554 27.4δδ 159.193 71.375 1.00 33, .48 D
ATOM 6ggo N GLY 555 27.323 15δ.053 69.456 1.00 33. .48 D ATOM 6ggι CA GLY 555 26.506 157.011 70.045 1..00 33.48 D
ATOM 6gg2 C GLY 555 25.227 157.391 70.745 1. .00 33 .48 D
ATOM 6g 3 O GLY 555 24.886 156. δ23 71.775 1. .00 33 .48 D
ATOM 6gg4 N LYS 556 24.513 15δ.356 70.188 1. .00 33 .48 D
ATOM 6gg5 CA LYS 556 23.241158.767 70.754 1. .00 33 .48 D
ATOM 6 g6 CB LYS 556 22.9gθ 160.257 70.509 1. .00 33 .48 D
ATOM 6 7 CG LYS 556 23.235 161.139 71.727 1. ,00 33 .48 D
ATOM 6ggδ CD LYS 556 22.778 162.589 71.459 1, ,00 33 .48 D
ATOM 6ggg CE LYS 556 22.g44 163.516 72.674 1, ,00 33 .48 D
ATOM 7000 NZ LYS 556 22.566 164.922 72.327 1, ,00 33 .48 D
ATOM 7001 C LYS 556 22.167 157.947 70.057 1. .00 33 .48 D
ATOM 7002 0 LYS 556 22.377 157.437 68.956 1. ,00 33, .48 D
ATOM 7003 N ILE 557 21.018 157.823 70.701 1. ,00 33 .48 D
ATOM 7004 CA ILE 557 19.917 157.074 70.130 1, ,00 33 .48 D
ATOM 7005 CB ILE 557 18.9g7 156.573 71.242 1, ,00 33 .48 D
ATOM 7006 CG2 ILE 557 17.δ58 155.758 70.654 1. ,00 33, .48 D
ATOM 7007 CGl ILE 557 ιg.80δ 155.741 72.235 1. ,00 33, .4δ D
ATOM 700δ CDl ILE 557 ig.042 155.400 73.505 1, ,00 33 .4δ D
ATOM 7oog C ILE 557 19.092 157.913 69.147 1. ,00 33 .48 D
ATOM 7010 O ILE 557 lδ.483 158.910 69.521 1. ,00 33 .48 D
ATOM 7011 N PRO 558 19.066 157.510 67.δ69 1. ,00 33 .48 D
ATOM 7012 CD PRO 558 19.810 156.372 67.315 1, ,00 33 .48 D
ATOM 7013 CA PRO 558 lδ.324 158.195 66.807 1, ,00 33 .48 D
ATOM 7014 CB PRO 558 lδ.637 157.355 65.572 1, ,00 33 .48 D
ATOM 7015 CG PRO 558 19.g66156.787 65.877 1, ,00 33 .48 D
ATOM 7016 C PRO 558 16.832 158.179 67.127 1. ,00 33 .48 D
ATOM 7017 O PRO 558 16.356 157.267 67.802 1. ,00 33 .48 D
ATOM 701δ N TYR 559 16.107 159.180 66.627 1, ,00 33 .48 D
ATOM 7019 CA TYR 559 14.670 159.311 66.852 1, ,00 33 .48 D
ATOM 7020 CB TYR 559 13.g02 158.511 65.814 1, ,00 33, .4δ D
ATOM 7021 CG TYR 559 i4.2gg 15δ.δδ7 64.417 1. ,00 33, .48 D
ATOM 7022 CDl TYR 559 15.315 158.214 63.752 1. ,00 33, .48 D
ATOM 7023 CEl TYR 559 15.714 158.594 62.483 1. ,00 33 .48 D
ATOM 7024 CD2 TYR 559 13.6g3 159.g4 63.777 1, ,00 33 .48 D
ATOM 7025 CE2 TYR 559 14.080 160.335 62.5ig 1. ,00 33, .48 D
ATOM 7026 CZ TYR 559 15.091159.661 61.874 1, ,00 33 .48 D
ATOM 7027 OH TYR 559 15.48δ 160.09δ 60.62g 1, ,00 33 .48 D
ATOM 7028 C TYR 559 14.319 158.848 68.246 1, .00 33 .48 D
ATOM 7029 0 TYR 559 13.266 158.257 68.477 1. .00 33 .48 D
ATOM 7030 N GLU 560 15.236 159.122 6g .168 1, ,00 33 .48 D
ATOM 7031 CA GLU 560 15.0δ2 158.772 70.571 1, ,00 33 .48 D
ATOM 7032 CB GLU 560 i5.7gg 159.816 71.439 1, ,00 33 .4δ D
ATOM 7033 CG GLU 560 15.5ig 159.734 72.934 1, ,00 33 .4δ D
ATOM 7034 CD GLU 560 15.δ2δ 158.372 73.550 1. ,00 33, .4δ D ATOM 7035 OEl GLU 560 15.066 157.401 73.309 1.00 33.48 D
ATOM 7036 OE2 GLU 560 16.846 158.282 74.285 1.00 33.48 D
ATOM 7037 C GLU 560 13.6og 158.6g6 70.935 1.00 33.48 D
ATOM 703δ O GLU 560 12.835 159.610 70.665 1.00 33.48 D
ATOM 703g N ASN 561 13.226 157.592 71.556 1.00 33.48 D
ATOM 7040 CA ASN 561 11.836 157.36δ 71.951 1.00 33.48 D
ATOM 7041 CB ASN 561 11.341 158.501 72.85δ 1.00 33.4δ D
ATOM 7042 CG ASN 561 12.473 159.308 73.441 1.00 33.4δ D
ATOM 7043 ODl ASN 561 12.g76 160.232 72.799 1.00 33.4δ D
ATOM 7044 ND2 ASN 561 12.8gδ 15δ.959 74.65δ 1.00 33.48 D
ATOM 7045 C ASN 561 ιo.g4g 157.263 70.702 1.00 33.48 D
ATOM 7046 O ASN 561 10.951 156.224 70.022 1.00 33.48 D
ATOM 7047 N ARG 562 10.207 15δ.334 70.420 1.00 33.48 D
ATOM 704δ CA ARG 562 9.319 158.391 69.26g 1.00 33.48 D
ATOM 704g CB ARG 562 9.917 159.320 6δ.20g 1.00 33.4δ D
ATOM 7050 CG ARG 562 10.429 160.642 6δ.751 1.00 33.4δ D
ATOM 7051 CD ARG 562 9.300 161.610 68.g8δ 1.00 33.48 D
ATOM 7052 NE ARG 562 δ.δ79 162.259 67.751 1.00 33.48 D
ATOM 7053 CZ ARG 562 7.631 162.662 67.506 1.00 33.48 D
ATOM 7054 NHl ARG 562 6.681 162.470 6δ.426 1.00 33.48 D
ATOM 7055 NH2 ARG 562 7.332 163.259 66.347 1.00 33.48 D
ATOM 7056 C ARG 562 9.145 156.998 6δ.675 1.00 33.4δ D
ATOM 7057 O ARG 562 10.000 156.542 67.910 1.00 33.4δ D
ATOM 705δ N SER 563 8.062 156.311 69.016 1.00 33.4δ D
ATOM 705g CA SER 563 7.δ5δ 154.968 68.478 1.00 33.4δ D
ATOM 7060 CB SER 563 6.530 154.387 68.948 1.00 33.48 D
ATOM 7061 OG SER 563 6.2δ7 153.141 6δ.304 1.00 33.48 D
ATOM 7062 C SER 563 7.δ94 154.931 66.956 1.00 33.4δ D
ATOM 7063 O SER 563 7.655 155.938 66.293 1.00 33.4δ D
ATOM 7064 N ASN 564 8.185 153.754 66.411 1.00 33.48 D
ATOM 7065 CA ASN 564 8.25δ 153.579 64.960 1.00 33.48 D
ATOM 7066 CB ASN 564 8.214 152. osg 64.574 1.00 33.48 D
ATOM 7067 CG ASN 564 9.174 151.238 65.390 1.00 33.48 D
ATOM 7068 ODl ASN 564 δ.924 150. g62 66.567 1.00 33.48 D
ATOM 706g ND2 ASN 564 10.277 150.823 64.776 1.00 33.48 D
ATOM 7070 C ASN 564 7.0δ3 154.2gδ 64.30δ 1.00 33.48 D
ATOM 7071 0 ASN 564 7.272 155.160 63.437 1.00 33.48 D
ATOM 7072 N SER 565 5.δ70 153. g3g 64.729 1.00 33.48 D
ATOM 7073 CA SER 565 4.67δ 154.56g 64.184 1.00 33.48 D
ATOM 7074 CB SER 565 3.4g2 154.408 65.142 1.00 33.48 D
ATOM 7075 OG SER 565 2.323 155.056 64.635 1.00 33.48 D
ATOM 7076 C SER 565 5.001 156.044 64.007 1.00 33.4δ D
ATOM 7077 0 SER 565 4.g24 156.577 62.900 1.00 33.4δ D
ATOM 7078 N GLU 566 5.3go 156.6g3 65.100 1.00 33.4δ D ATOM 707g CA GLU 566 5.725 158.109 65.036 1.00 33.48 D
ATOM 7080 CB GLU 566 6.184 158.631 66.401 1.00 33.48 D
ATOM 7081 CG GLU 566 5 . 3g4 158.123 67.5δ3 1.00 33.4δ D
ATOM 7082 CD GLU 566 5 . 267 159.172 6δ.674 1.00 33.48 D
ATOM 7083 OEl GLU 566 6.264 159.872 6δ.961 1.00 33.48 D
ATOM 7084 OE2 GLU 566 4.168 15g.2 3 6g.255 1.00 33.4δ D
ATOM 7085 C GLU 566 6.847 158.333 64.035 1.00 33.4δ D
ATOM 7086 O GLU 566 6.704159.107 63.0g5 1.00 33.4δ D
ATOM 7087 N VAL 567 7.968 157.651 64.256 1.00 33.4δ D
ATOM 708δ CA VAL 567 9. 142 157.780 63.3g6 1.00 33.4δ D
ATOM 708g CB VAL 567 10.146 156.650 63.646 1.00 33.4δ D
ATOM 7ogo CGl VAL 567 11. 311156.766 62.677 1.00 33.48 D
ATOM 7ogι CG2 VAL 567 10. 624 156.707 65.0δ7 1.00 33.48 D
ATOM 70g2 C VAL 567 8. 776 157.752 61.936 1.00 33.4δ D
ATOM 7093 O VAL 567 9.153 158.644 61.171 1.00 33.4δ D
ATOM 7094 N VAL 568 8.034 156.720 61.555 1.00 33.4δ D
ATOM 7095 CA VAL 568 7.617 156.560 60.174 1.00 33.4δ D
ATOM 7096 CB VAL 568 6.965 155.203 59.g57 1.00 33.48 D
ATOM 7097 CGl VAL 568 5 .469 155.318 60.211 1.00 33.48 D
ATOM 7098 CG2 VAL 56δ 7. 287 154.695 58.552 1.00 33.4δ D
ATOM 709g C VAL 56δ 6.615 157.648 5g.812 1.00 33.4δ D
ATOM 7100 O VAL 568 6.287 157.854 5δ.639 1.00 33.48 D
ATOM 7101 N GLU 56g 6.144 158.351 60.834 1.00 33.48 D
ATOM 7102 CA GLU 56 5 .185 159.426 60.646 1.00 33.48 D
ATOM 7103 CB GLU 56g 4.273 159.524 61.864 1.00 33.48 D
ATOM 7104 CG GLU 56g 3 .083 160.411 61.629 1.00 33.48 D
ATOM 7105 CD GLU 56g 2. 543 160.281 60.208 1.00 33.48 D
ATOM 7106 OEl GLU 56g 2.454 159.129 59.711 1.00 33.4δ D
ATOM 7107 OE2 GLU 569 2.201161.333 59.601 1.00 33.4δ D
ATOM 710δ C GLU 569 5 .858 160.773 60.404 1.00 33.4δ D
ATOM 7iog O GLU 56g 5 .192 161.763 60.129 1.00 33.4δ D
ATOM 7110 N ASP 570 7.180160.817 60.493 1.00 33.48 D
ATOM 7111 CA ASP 570 7.876 162.073 60.278 1.00 33.48 D
ATOM 7112 CB ASP 570 8.820 162.367 61.440 1.00 33.48 D
ATOM 7113 CG ASP 570 8.098 162.444 62.767 1.00 33.4δ D
ATOM 7114 ODl ASP 570 7. 692 161.380 63.283 1.00 33.4δ D
ATOM 7115 OD2 ASP 570 7.929 163.572 63.290 1.00 33.4δ D
ATOM 7116 C ASP 570 8 . 653 162.062 58.975 1.00 33.4δ D
ATOM 7117 O ASP 570 8.49g 162.970 58.158 1.00 33.4δ D
ATOM 7118 N ILE 571 g . 502 161.050 58.7δ9 1.00 33.4δ D
ATOM 7119 CA ILE 571 10.281160.936 57.55g 1.00 33.4δ D
ATOM 7120 CB ILE 571 10.833 lsg.sog 57.354 1.00 33.4δ D
ATOM 7121 CG2 ILE 571 11.263 15g.335 55.gi6 1.00 33.48 D
ATOM 7122 CGl ILE 571 12.004 159.241 58.308 1.00 33.48 D ATOM 7123 CDl ILE 571 11.624 15g.227 5g.775 1.0033.,48 D
ATOM 7124 C ILE 571 g.275 161.216 56.471 1.00 33. ,48 D
ATOM 7125 0 ILE 571 g.569 161.850 55.457 1.00 33. ,48 D
ATOM 7126 N SER 572 δ.067 160.728 56.72g 1.00 33. ,48 D
ATOM 7127 CA SER 572 6.92δ 160.8g6 55.841 1.00 33, .48 D
ATOM 712δ CB SER 572 5.715 160.175 56.440 1.00 33, .48 D
ATOM 712g OG SER 572 5.473 160.607 57.779 1.00 33, .48 D
ATOM 7130 C SER 572 6.644 162.3g6 55.713 1.00 33, .48 D
ATOM 7131 0 SER 572 6.632 162.942 54.606 1.00 33, .48 D
ATOM 7132 N THR 573 6.421 163.046 56.858 1.00 33, .48 D
ATOM 7133 CA THR 573 6.162 164.4δ3 56.921 1.00 33 .48 D
ATOM 7134 CB THR 573 5.734 164.920 58.332 1.00 33, .48 D
ATOM 7135 OGl THR 573 4.643 164.111 5δ.790 1.00 33, .48 D
ATOM 7136 CG2 THR 573 5.29δ 166.374 5δ.324 1.00 33, .48 D
ATOM 7137 C THR 573 7.459 165.221 56.613 1.00 33, .48 D
ATOM 713δ 0 THR 573 7.641 166.359 57.037 1.00 33, .48 D
ATOM 713g N GLY 574 8.370 164.566 ss.δgg 1.00 33, .48 D
ATOM 7140 CA GLY 574 9.635 165. ιgg 55.569 1.00 33, .48 D
ATOM 7141 C GLY 574 10.515 165.584 56.757 1.00 33, .48 D
ATOM 7142 0 GLY 574 11.386 166.447 56.636 1.00 33, .48 D
ATOM 7143 N PHE 575 10.306 164. g47 57.903 1.00 33, .48 D
ATOM 7144 CA PHE 575 11.103 165.255 59.080 1.00 33, .48 D
ATOM 7145 CB PHE 575 10.254 165.115 60.342 1.00 33, .48 D
ATOM 7146 CG PHE 575 9.426 166.321 60.634 1.00 33, .48 D
ATOM 7147 CDl PHE 575 10.032 167.520 60.972 1.00 33, .48 D
ATOM 714δ CD2 PHE 575 8.046 166.284 60.515 1.00 33, .48 D
ATOM 714g CEl PHE 575 9.284 168.657 61.182 1.00 33 .48 D
ATOM 7150 CE2 PHE 575 7.294 167.427 60.726 1.00 33 .48 D
ATOM 7151 CZ PHE 575 7.917 168.611 61.058 1.00 33 .48 D
ATOM 7152 C PHE 575 12.361 164.3gg 59.206 1.00 33 .48 D
ATOM 7153 0 PHE 575 12.329 163.184 58.96g 1.00 33 .48 D
ATOM 7154 N ARG 576 13.45g 165.054 sg.sδg 1.00 33 .48 D
ATOM 7155 CA ARG 576 14.748 164.40δ 5g.765 1.00 33 .48 D
ATOM 7156 CB ARG 576 15.73g 164. g47 58.750 1.00 33 .48 D
ATOM 7157 CG ARG 576 15.285 164.776 57.332 1.00 33 .48 D
ATOM 715δ CD ARG 576 14.450 163.52g 57.1δ5 1.00 33 .48 D
ATOM 715g NE ARG 576 14.238 163.164 55.7g3 1.00 33 .48 D
ATOM 7160 CZ ARG 576 13.105 162.65 55.328 1.00 33 .48 D
ATOM 7161 NHl ARG 576 12.081 162.474 56.143 1.00 33 .48 D
ATOM 7162 NH2 ARG 576 13.004 162.316 54.055 1.00 33 .48 D
ATOM 7163 C ARG 576 15.308 164.632 61.163 1.00 33 .48 D
ATOM 7164 0 ARG 576 14.6g6 165.283 εi.ggi 1.00 33 .48 D
ATOM 7165 N LEU 577 16.476 164.076 61.431 1.00 33 .48 D
ATOM 7166 CA LEU 577 17.0g6 164.248 62.726 1.00 33 .48 D ATOM 7167 CB LEU 577 18.152 163.160 62.942 1.00 33,.48 D
ATOM 7168 CG LEU 577 17.591 161.737 62.906 1.00 33 .48 D
ATOM 716g CDl LEU 577 18.707 160.693 62.867 1.00 33, .48 D
ATOM 7170 CD2 LEU 577 16.719 161.544 64.129 1.00 33, .48 D
ATOM 7171 C LEU 577 17.751 165.611 62.66δ 1.00 33, .48 D
ATOM 7172 0 LEU 577 18.002 166.114 61.577 1.00 33, .48 D
ATOM 7173 N TYR 57δ 18.019 166.216 63.δ23 1.00 33, .48 D
ATOM 7174 CA TYR 578 18.664 167.522 63.δ3δ 1.00 33, .48 D
ATOM 7175 CB TYR 578 18.393 16δ.269 65.148 1.00 33, .48 D
ATOM 7176 CG TYR 578 16.974 168.751 65.30δ 1.00 33, .48 D
ATOM 7177 CDl TYR 578 16.105 168.127 66.195 1.00 33, .48 D
ATOM 7178 CEl TYR 578 14.805 16δ.544 66.327 1.00 33, .48 D
ATOM 717g CD2 TYR 578 16.492 16g.814 64.555 1.00 33, .48 D
ATOM 7180 CE2 TYR 578 15.191170.237 64.6δ3 1.00 33, .48 D
ATOM 7181 CZ TYR 578 14.353 i6g.5gg 65.572 1.00 33, .48 D
ATOM 7182 OH TYR 57δ 13.053 170.031 65.731 1.00 33, .48 D
ATOM 7183 C TYR 578 20.164 167.374 63.65δ 1.00 33, .48 D
ATOM 7184 0 TYR 578 20.710 166.283 63.809 1.00 33, .48 D
ATOM 7185 N LYS 57g 20.δ27 168.481 63.336 1.00 33, .48 D
ATOM 7186 CA LYS 57g 22.264 168.473 63.144 1.00 33, .48 D
ATOM 7187 CB LYS 57g 22.706 169.741 62.426 1.00 33, .48 D
ATOM 7188 CG LYS 57g 23.949 170.368 63.008 1.00 33 .48 D
ATOM 718g CD LYS 57 24.604 171.294 62.006 1.00 33, .48 D
ATOM 7igo CE LYS 579 25.624 172.222 62.652 1.00 33, .48 D
ATOM 7191 NZ LYS 579 26.δ03 171.535 63.222 1.00 33, .48 D
ATOM 7192 C LYS 579 23.023 168.351 64.453 1.00 33, .48 D
ATOM 7193 0 LYS 579 22.720 169.043 65.425 1.00 33, ,48 D
ATOM 7194 N PRO 580 23.980 167.412 64.513 1.00 33, .48 D
ATOM 7195 CD PRO 580 23.927 166.156 63.747 1.00 33, .48 D
ATOM 7196 CA PRO 580 24.773 167.237 65.732 1.00 33, .48 D
ATOM 7197 CB PRO 580 25.194 165.769 65.667 1.00 33, .48 D
ATOM 719δ CG PRO 580 25.136 165.440 64.231 1.00 33, .48 D
ATOM 7igg C PRO 580 25.937 168.227 65.749 1.00 33, .48 D
ATOM 7200 0 PRO 580 26.665 168.358 64.776 1.00 33, .48 D
ATOM 7201 N ARG 581 26.087 168.92g 66.δ67 1.00 33, .48 D
ATOM 7202 CA ARG 581 27.108 16g.g55 67.027 1.00 33, .48 D
ATOM 7203 CB ARG 581 27.390 170.211 6δ.506 1.00 33 .48 D
ATOM 7204 CG ARG 581 28.100 171.538 6δ.75δ 1.00 33, .48 D
ATOM 7205 CD ARG 581 29.376 171.413 69.5δ7 1.00 33 .48 D
ATOM 7206 NE ARG 581 30.456 172.178 6δ.g51 1.00 33 .48 D
ATOM 7207 CZ ARG 581 31.671 172.375 6g.470 1.00 33, .48 D
ATOM 720δ NHl ARG 581 31.987 171.872 70.662 1.00 33, .48 D
ATOM 720g NH2 ARG 581 32.585 173.04g 68.776 1.00 33, .48 D
ATOM 7210 C ARG 581 2δ.423 i6g.6go 66.331 1.00 33, .48 D ATOM 7211 0 ARG 581 28.963 170.570 65.664 1.00 33,.48 D
ATOM 7212 N LEU 582 28.g4g 16δ.4δ4 66.486 1.00 33, .48 D
ATOM 7213 CA LEU 582 30.227 168.148 65.887 1.00 33, .48 D
ATOM 7214 CB LEU 582 30.δ03 166.933 66. 5gg 1.00 33, .48 D
ATOM 7215 CG LEU 582 31.245 167.291 68.018 1.00 33, .48 D
ATOM 7216 CDl LEU 582 31.087 166.106 68.g33 1.00 33 .48 D
ATOM 7217 CD2 LEU 582 32.672 167.789 67.gδδ 1.00 33, .48 D
ATOM 7218 C LEU 582 30.214 167. g2g 64.3δ2 1.00 33, .48 D
ATOM 7219 0 LEU 582 31.269 167.8δ9 63.761 1.00 33 .48 D
ATOM 7220 N ALA 583 2g.034 167. δ04 63.7δ7 1.00 33, .48 D
ATOM 7221 CA ALA 583 28.g40 167.596 62.347 1.00 33 .48 D
ATOM 7222 CB ALA 583 27.726 166.745 62.017 1.00 33 .48 D
ATOM 7223 C ALA 5δ3 28.85116δ.922 61.604 1.00 33, .48 D
ATOM 7224 0 ALA 5δ3 27.87δ 169.663 61.765 1.00 33, .48 D
ATOM 7225 N SER 5δ4 2g.δ50 169.22g 60.783 1.00 33, .48 D
ATOM 7226 CA SER 584 2g.δl6 170.477 60.035 1.00 33, .48 D
ATOM 7227 CB SER 584 30.g44 170.512 sg.oos 1.00 33, .48 D
ATOM 7228 OG SER 584 30.775 169.512 58.011 1.00 33, .48 D
ATOM 7229 C SER 584 2δ.473 170.63δ 5g.3ig 1.00 33, .48 D
ATOM 7230 0 SER 584 27.7g2 169.657 5g.017 1.00 33, .48 D
ATOM 7231 N THR 585 2δ.0δ5 171.878 59.052 1.00 33, .48 D
ATOM 7232 CA THR 585 26.δ33 172.116 58.354 1.00 33, .48 D
ATOM 7233 CB THR 585 26.5g6 173.616 58.15g 1.00 33, .48 D
ATOM 7234 OGl THR 585 27.δ34 174.255 57.δ46 1.00 33, .48 D
ATOM 7235 CG2 THR 585 26.040 174.232 5g.425 1.00 33, .48 D
ATOM 7236 C THR 585 26.g3δ 171.410 57. oog 1.00 33, .48 D
ATOM 7237 0 THR 585 25.g45 170.943 56.453 1.00 33, .48 D
ATOM 7238 N HIS 586 2δ.l65 171.320 56.502 1.00 33, .48 D
ATOM 7239 CA HIS 586 28.431170.652 55.233 1.00 33, .48 D
ATOM 7240 CB HIS 586 2g.g28 170.679 54.g3δ 1.00 33, .48 D
ATOM 7241 CG HIS 586 30.280 170.275 53.540 1.00 33, .48 D
ATOM 7242 CD2 HIS 586 31.415 170.451 52.821 1.00 33. .48 D
ATOM 7243 NDl HIS 586 2g.407 169.5g6 52.717 1.00 33, .48 D
ATOM 7244 CEl HIS 586 29.988 169.372 51.551 1.00 33, .48 D
ATOM 7245 NE2 HIS 5δ6 31.206 169.881 51.588 1.00 33, .48 D
ATOM 7246 C HIS 5δ6 27.973 lεg.igg 55.344 1.00 33, .48 D
ATOM 7247 0 HIS 586 27.158 168.727 54.54g 1.00 33, ,48 D
ATOM 7248 N VAL 587 28.513 168.506 56.346 1.00 33, .48 D
ATOM 7249 CA VAL 587 2δ.206 167.104 56.616 1.00 33, .48 D
ATOM 7250 CB VAL 587 28.917 166.631 57.8δg 1.00 33, .48 D
ATOM 7251 CGl VAL 587 28.317 165.327 58.352 1.00 33, .48 D
ATOM 7252 CG2 VAL 587 30.39δ 166.47g 57.636 1.00 33, .48 D
ATOM 7253 C VAL 587 26.716 166. δ35 56.80g 1.00 33, .48 D
ATOM 7254 0 VAL 587 26.176 165.832 56.32g 1.00 33, .48 D ATOM 7255 N TYR 5δδ 26.058 167.729 57.536 1.00 33.,48 D
ATOM 7256 CA TYR 5δδ 24.647 167.569 57.804 1.00 33. .48 D
ATOM 7257 CB TYR 588 24.204 16δ.5δ7 58.847 1.00 33. .48 D
ATOM 7258 CG TYR 58δ 22.778 16δ.423 5g.286 1.00 33. .48 D
ATOM 725g CDl TYR 588 22.386 167.324 60.024 1.00 33. .48 D
ATOM 7260 CEl TYR 588 21.065 167.146 60.3δ0 1.00 33, ,48 D
ATOM 7261 CD2 TYR 588 21.810 169.348 5δ.917 1.00 33, ,48 D
ATOM 7262 CE2 TYR 58δ 20.489 169.178 59.263 1.00 33, ,48 D
ATOM 7263 CZ TYR 5δ8 20.121 16δ.073 59.gg3 1.00 33, ,48 D
ATOM 7264 OH TYR 588 18.79δ 167.882 60.313 1.00 33, ,48 D
ATOM 7265 C TYR 588 23.887 167.737 56.4g6 1.00 33. .48 D
ATOM 7266 O TYR 58δ 22.728 167.318 56.372 1.00 33, .48 D
ATOM 7267 N GLN 58 24.532 168.354 55.510 1.00 33, .48 D
ATOM 7268 CA GLN 58g 23.δ72 168.490 54.220 1.00 33, .48 D
ATOM 726g CB GLN 5δg 24.633 169.437 53.270 1.00 33, .48 D
ATOM 7270 CG GLN 5δ 24.405 170.943 53.524 1.00 33, .48 D
ATOM 7271 CD GLN 5δg 24.721 171.829 52.302 1.00 33, .48 D
ATOM 7272 OEl GLN 5δg 24.12δ 171.653 51.233 1.00 33, ,48 D
ATOM 7273 NE2 GLN 5δg 25.651172.7δ6 52.464 1.00 33, .48 D
ATOM 7274 C GLN 58g 23.δ21 167.073 53.640 1.00 33, .48 D
ATOM 7275 O GLN 5δg 22.74δ 166.585 53.266 1.00 33, .48 D
ATOM 7276 N ILE sgo 24.g7g 166.4og 53.606 1.00 33, .48 D
ATOM 7277 CA ILE sgo 25.0δ0 165.043 53. ogo 1.00 33, .48 D
ATOM 7278 CB ILE sgo 26.545 164.538 53.127 1.00 33, .48 D
ATOM 7279 CG2 ILE sgo 26.610 163. og7 52.70g 1.00 33, .48 D
ATOM 7280 CGl ILE sgo 27.396 165.346 52.143 1.00 33, .48 D
ATOM 7281 CDl ILE sgo 2δ.890 165.325 52.425 1.00 33, .48 D
ATOM 7282 C ILE sgo 24.180 164.086 53.870 1.00 33, .48 D
ATOM 72δ3 O ILE sgo 23.4g6 163.252 53.283 1.00 33, .48 D
ATOM 72δ4 N MET s i 24.162 164.210 55.191 1.00 33, .48 D
ATOM 7285 CA MET sgi 23.308 163.33g 55.9δ6 1.00 33, .48 D
ATOM 7286 CB MET 591 23.347 163.742 57.46g 1.00 33, .48 D
ATOM 7287 CG MET 591 24.760 163.856 5δ.03g 1.00 33, .48 D
ATOM 7288 SD MET 591 24.840 163. gδ3 5g.847 1.00 33, .48 D
ATOM 7289 CE MET 591 23.243 163.381 60.273 1.00 33, .48 D
ATOM 72go C MET 591 21.889 163.443 55.438 1.00 33 .48 D
ATOM 72gi 0 MET 591 21.117 162.487 55.476 1.00 33 .48 D
ATOM 72g2 N ASN 592 21.560 164.614 54.g04 1.00 33 .48 D
ATOM 72g3 CA ASN 592 20.230164.852 54.350 1.00 33, .48 D
ATOM 7294 CB ASN 592 19.900 166.341 54.3δ4 1.00 33, .48 D
ATOM 7295 CG ASN 592 19.232 166.74g 55.678 1.00 33, .48 D
ATOM 72g6 ODl ASN 592 18.012 166.606 55.833 1.00 33 .48 D
ATOM 7297 ND2 ASN 592 20.031 167.232 56.62g 1.00 33 .48 D
ATOM 7298 C ASN 592 20.063 164.324 52.g46 1.00 33, .48 D ATOM 729g O ASN 5g2 ig.026 163.748 52.615 1.0033,.48 D
ATOM 7300 N HIS 5 3 21.078 164.515 52.113 1.00 33, .48 D
ATOM 7301 CA HIS 5g3 21.000 164.010 50.758 1.00 33 .48 D
ATOM 7302 CB HIS 5g3 22.284 164.280 50.004 1.00 33, .48 D
ATOM 7303 CG HIS 5g3 22.157 164.070 48.52g 1.00 33 .48 D
ATOM 7304 CD2 HIS 5g3 21.081 163.762 47.766 1.00 33 .48 D
ATOM 7305 NDl HIS 5g3 23.218 164.219 47.657 1.00 33 .48 D
ATOM 7306 CEl HIS 5g3 22.7g8 164.014 46.421 1.00 33 .48 D
ATOM 7307 NE2 HIS 5g3 21.506 163.735 46.460 1.00 33 .48 D
ATOM 7308 C HIS 5g3 20.787 162.512 50.846 1.00 33 .48 D
ATOM 730g O HIS 593 20.252 161.898 4g. 38 1.00 33 .48 D
ATOM 7310 N CYS 594 21.221161.931 51.957 1.00 33 .48 D
ATOM 7311 CA CYS 594 21.079 160.506 52.ig4 1.00 33, .48 D
ATOM 7312 CB CYS 594 22.034 160.057 53.303 1.00 33, .48 D
ATOM 7313 SG CYS 594 23.775 159. g56 52.824 1.00 33 .48 D
ATOM 7314 C CYS 5g4 ig.657 160.194 52.606 1.00 33, .48 D
ATOM 7315 O CYS 5g4 19.146 159.112 52.347 1.00 33, .48 D
ATOM 7316 N TRP s s 19.005 161.150 53.246 1.00 33, .48 D
ATOM 7317 CA TRP s s 17.653 160.910 53.703 1.00 33, .48 D
ATOM 7318 CB TRP sgs 17.424 161.596 55.045 1.00 33, .48 D
ATOM 73ig CG TRP 595 lδ.390 161.164 56.118 1.00 33, .48 D
ATOM 7320 CD2 TRP 595 lδ.g25 161.974 57.166 1.00 33, .48 D
ATOM 7321 CE2 TRP 595 ig.731 161.143 57.969 1.00 33, .48 D
ATOM 7322 CE3 TRP 595 iδ.7gg 163.320 57.506 1.00 33, .48 D
ATOM 7323 CDl TRP 595 lδ.δδi 159. go6 56.321 1.00 33, .48 D
ATOM 7324 NEl TRP 595 ιg.68g 159.8δ5 57.432 1.00 33, .48 D
ATOM 7325 CZ2 TRP 595 20.408 161.615 59.091 1.00 33, .48 D
ATOM 7326 CZ3 TRP 595 19.471 163.78g 58.624 1.00 33 .48 D
ATOM 7327 CH2 TRP 595 20.267 162. 36 59.404 1.00 33, .48 D
ATOM 7328 C TRP 595 16.592 161.331 52.707 1.00 33, .48 D
ATOM 732g O TRP sgs 15.411 161.375 53.03δ 1.00 33, .48 D
ATOM 7330 N LYS 5g6 17.011161.645 51.486 1.00 33, .48 D
ATOM 7331 CA LYS 5g6 16.060 162.010 50.445 1.00 33, .48 D
ATOM 7332 CB LYS 5 6 16.784 162.200 49.114 1.00 33, .48 D
ATOM 7333 CG LYS 5g6 17.545 163.504 4g.003 1.00 33, .48 D
ATOM 7334 CD LYS 5gε 16.601 164.668 4g.ιg5 1.00 33, .48 D
ATOM 7335 CE LYS 5g6 17.297 166.006 48.gg3 1.00 33, .48 D
ATOM 7336 NZ LYS 5gε 16.317 167.147 4g.i2g 1.00 33, .48 D
ATOM 7337 C LYS 5gε 15.026 160.8δ4 50.315 1.00 33, .48 D
ATOM 7338 0 LYS 5gε 15.376 15g.712 50.28δ 1.00 33, .48 D
ATOM 733g N GLU sg7 13.748 161.221 50.243 1.00 33, .48 D
ATOM 7340 CA GLU 5g7 12.752 160.170 50.131 1.00 33, ,48 D
ATOM 7341 CB GLU 5g7 11.343 160.738 50.210 1.00 33, .48 D
ATOM 7342 CG GLU 5g7 10.282 isg.6g2 4g.g75 1.00 33, .48 D ATOM 7343 CD GLU 597 δ.8g7 160.190 50.337 1.00 33 .48 D
ATOM 7344 OEl GLU 597 8.583 161.359 49.g7g 1.00 33.48 D
ATOM 7345 OE2 GLU 597 8.129 159.4og 50.g71 1.00 33 .48 D
ATOM 7346 C GLU 597 12.g08 159.402 48.δ35 1.00 33 .48 D
ATOM 7347 O GLU 597 12.854158.172 4δ.δl3 1.00 33 .48 D
ATOM 734δ N ARG 59δ 13.103 160.122 47.743 1.00 33 .4δ D
ATOM 7349 CA ARG sg 13.25g 159.459 46.454 1.00 33.48 D
ATOM 7350 CB ARG sgδ 13.035 160.474 45.320 1.00 33 .48 D
ATOM 7351 CG ARG 59δ 12.636 159.819 44. oog 1.00 33 .48 D
ATOM 7352 CD ARG 598 12.177 160.826 42.g57 1.00 33.48 D
ATOM 7353 NE ARG 598 11.695 160.135 41.759 1.00 33 .48 D
ATOM 7354 CZ ARG 598 10.6g8 J.243 41.753 1.00 33 .4δ D
ATOM 7355 NHl ARG 598 10.064 158.92g 42.885 1.00 33.4δ D
ATOM 7356 NH2 ARG 598 10.33g 158.650 40.612 1.00 33 .48 D
ATOM 7357 C ARG 598 14.646 158.7g4 46.338 1.00 33 .48 D
ATOM 735δ O ARG 598 15.665 15g.467 46.184 1.00 33 .48 D
ATOM 7359 N PRO 59g 14.6gθ 157.457 46.427 1.00 33 .48 D
ATOM 7360 CD PRO sgg 13.531156.554 46.512 1.00 33.48 D
ATOM 7361 CA PRO sgg 15.g34 156.6g5 46.335 1.00 33 .48 D
ATOM 7362 CB PRO sgg 15.445 155.287 46.03g 1.00 33 .4δ D
ATOM 7363 CG PRO sgg 14.177 155.218 46.801 1.00 33.4δ D
ATOM 7364 C PRO 599 16.7g7 157.238 45.216 1.00 33 .48 D
ATOM 7365 O PRO 59 i7.gg7 157.500 45.385 1.00 33 .48 D
ATOM 7366 N GLU 600 16.15δ 157.410 44.068 1.00 33 .48 D
ATOM 7367 CA GLU 600 16.821157.915 42.891 1.00 33.48 D
ATOM 736δ CB GLU 600 15.786 158.240 41.821 1.00 33.48 D
ATOM 7369 CG GLU 600 14.δ26 157.091 41.495 1.00 33 .48 D
ATOM 7370 CD GLU 600 13.δ2g 156.762 42.625 1.00 33 .48 D
ATOM 7371 OEl GLU 600 14.273 156.293 43.700 1.00 33.48 D
ATOM 7372 OE2 GLU 600 12.5gδ 156.966 42.441 1.00 33 .48 D
ATOM 7373 C GLU 600 17.5δ5 159.162 43.302 1.00 33 .48 D
ATOM 7374 O GLU 600 18. εgδ 159.416 42.845 1.00 33 .48 D
ATOM 7375 N ASP 601 16.gδ6 159.917 44.210 1.00 33 .48 D
ATOM 7376 CA ASP 601 17.575 161.150 44.697 1.00 33.48 D
ATOM 7377 CB ASP 601 16.467 162.059 45.219 1.00 33 .48 D
ATOM 7378 CG ASP 601 15.682 162.702 44.100 1.00 33 .48 D
ATOM 7379 ODl ASP 601 16.282 163.558 43.3g7 1.00 33.48 D
ATOM 7380 OD2 ASP 601 14.48g 162.345 43.g27 1.00 33 .48 D
ATOM 7381 C ASP 601 lδ.656 161.001 45.760 1.00 33 .48 D
ATOM 7382 O ASP 601 ig.405 161.949 46.005 1.00 33 .48 D
ATOM 7383 N ARG 602 18.730 159.832 46.400 1.00 33 .48 D
ATOM 7384 CA ARG 602 19.741159.591 47.433 1.00 33.48 D
ATOM 7385 CB ARG 602 19.381158.353 4δ.258 1.00 33.48 D
ATOM 73δ6 CG ARG 602 18.647 158.670 49.543 1.00 33.48 D ATOM 7387 CD ARG 602 18.021 157.451 50.203 1.00 33.48 D
ATOM 738δ NE ARG 602 16.705 157.145 4g.648 1.00 33 .48 D
ATOM 73δ9 CZ ARG 602 15.805 156.344 50.215 1.00 33.48 D
ATOM 7390 NHl ARG 602 16.060 155.746 51.363 1.00 33 .48 D
ATOM 7391 NH2 ARG 602 14.629 156.157 4g.641 1.00 33.48 D
ATOM 7392 C ARG 602 21.064 159.391 46.731 1.00 33 .48 D
ATOM 7393 O ARG 602 21.112 158.774 45.6δ0 1.00 33.48 D
ATOM 7394 N PRO 603 22.151 159.941 47.280 1.00 33 .48 D
ATOM 7395 CD PRO 603 22.298 160.731 48.512 1.00 33 .48 D
ATOM 7396 CA PRO 603 23.445 159.761 46.618 1.00 33 .48 D
ATOM 7397 CB PRO 603 24.372 160.6δδ 47.406 1.00 33 .48 D
ATOM 739δ CG PRO 603 23.795 160.661 48.767 1.00 33.48 D
ATOM 7399 C PRO 603 23.877 158.29 46.678 1.00 33 .48 D
ATOM 7400 O PRO 603 23.252 157.487 47.368 1.00 33.48 D
ATOM 7401 N ALA 604 24.932 157. 63 45.g43 1.00 33.48 D
ATOM 7402 CA ALA 604 25.436 156. sgg 45.g24 1.00 33.48 D
ATOM 7403 CB ALA 604 25.716 156.170 44.500 1.00 33 .48 D
ATOM 7404 C ALA 604 26.713 156.544 46.750 1.00 33.48 D
ATOM 7405 O ALA 604 27.435 157.557 46.876 1.00 33 .48 D
ATOM 7406 N PHE 605 27.000155.373 47.315 1.00 33.48 D
ATOM 7407 CA PHE 605 2δ.l9δ 155.237 48.131 1.00 33.48 D
ATOM 740δ CB PHE 605 2δ.362 153.791 4δ.5gi 1.00 33.48 D
ATOM 7409 CG PHE 605 27.398 153.401 4g.671 1.00 33 .48 D
ATOM 7410 CDl PHE 605 27.498 153.960 50.932 1.00 33.48 D
ATOM 7411 CD2 PHE 605 26.353 152.531 49.408 1.00 33 .48 D
ATOM 7412 CEl PHE 605 26.574 153.663 51.909 1.00 33.48 D
ATOM 7413 CE2 PHE 605 25.423 152.229 50.381 1.00 33.48 D
ATOM 7414 CZ PHE 605 25.534 152.7g 51.635 1.00 33 .48 D
ATOM 7415 C PHE 605 29.423 155.710 47.368 1.00 33.48 D
ATOM 7416 O PHE 605 30.273 156.425 47.901 1.00 33.48 D
ATOM 7417 N SER 606 29.501155.338 46.104 1.00 33.48 D
ATOM 7418 CA SER 606 30.640 155.751 45.319 1.00 33.48 D
ATOM 7419 CB SER 606 30.460 155.316 43.868 1.00 33.48 D
ATOM 7420 OG SER 606 29.252 155.827 43.342' 1.00 33.48 D
ATOM 7421 C SER 606 30.840157.261 45.389 1.00 33.48 D
ATOM 7422 O SER 606 31.970 157.743 45.325 1.00 33.48 D
ATOM 7423 N ALA 607 29.753 158.015 45.533 1.00 33.48 D
ATOM 7424 CA ALA 607 29.862 15g.474 45.580 1.00 33.48 D
ATOM 7425 CB ALA 607 2δ.5δδ 160.106 45.051 1.00 33.48 D
ATOM 7426 C ALA 607 30.172 160.000 46.9δ0 1.00 33 .48 D
ATOM 7427 O ALA 607 31.084160.820 47.153 1.00 33.48 D
ATOM 7428 N LEU 608 29.40δ 159.531 47.g68 1.00 33.48 D
ATOM 7429 CA LEU 608 2g.602 15g. 47 4g.354 1.00 33.48 D
ATOM 7430 CB LEU 608 2δ.826 159.018 50.277 1.00 33.48 D ATOM 7431 CG LEU 60δ 27.328 159.034 50.040 1.00 33.4δ D
ATOM 7432 CDl LEU 60δ 26.662 158.002 50.8g2 1.00 33.48 D
ATOM 7433 CD2 LEU 608 26.794 160.393 50.3δO 1.00 33.48 D
ATOM 7434 C LEU 608 31.088 159.848 4g.65g 1.00 33.4δ D
ATOM 7435 O LEU 608 31.684 160.708 50.304 1.00 33.48 D
ATOM 7436 N LEU 609 31.664 158.758 4g.iδθ 1.00 33.48 D
ATOM 7437 CA LEU 609 33.068 158.470 4g.342 1.00 33.4δ D
ATOM 7438 CB LEU 609 33.375 157.186 48.571 1.00 33.4δ D
ATOM 743g CG LEU 6og 34.798 156.751 48.242 1.00 33.48 D
ATOM 7440 CDl LEU 6og 35.564 156.375 4g.503 1.00 33.48 D
ATOM 7441 CD2 LEU 609 34.706 155.575 47.275 1.00 33.48 D
ATOM 7442 C LEU 609 33.836 159.65 48.783 1.00 33.48 D
ATOM 7443 O LEU 609 34.636 160.273 49.483 1.00 33.48 D
ATOM 7444 N ARG 610 33.553 15g.g86 47.522 1.00 33.4δ D
ATOM 7445 CA ARG 610 34.1δ3 161.101 46.δ01 1.00 33.4δ D
ATOM 7446 CB ARG 610 33.523 161.239 45.425 1.00 33.4δ D
ATOM 7447 CG ARG 610 34.355 161.842 44.282 1.00 33.48 D
ATOM 7448 CD ARG 610 33.409 162.016 43.069 1.00 33.48 D
ATOM 744g NE ARG 610 33.9gθ 161.666 41.765 1.00 33.48 D
ATOM 7450 CZ ARG 610 34.7g2 162.455 41.038 1.00 33.48 D
ATOM 7451 NHl ARG 610 35.137 163.670 41.471 1.00 33.48 D
ATOM 7452 NH2 ARG 610 35.242 162.030 39.85g 1.00 33.4δ D
ATOM 7453 C ARG 610 34.037 162.417 47.57g 1.00 33.4δ D
ATOM 7454 O ARG 610 34.g3δ 163.264 47.566 1.00 33.48 D
ATOM 7455 N GLN 611 32. goo 162.583 4δ.251 1.00 33.48 D
ATOM 7456 CA GLN 611 32.637 163.776 4g.043 1.00 33.48 D
ATOM 7457 CB GLN 611 31.136 163.908 4g.2δl 1.00 33.4δ D
ATOM 745δ CG GLN 611 30.342 163.805 47.gg7 1.00 33.4δ D
ATOM 7459 CD GLN 611 28.851 164.109 48.154 1.00 33.4δ D
ATOM 7460 OEl GLN 611 28.114 163.421 48.883 1.00 33.48 D
ATOM 7461 NE2 GLN 611 28.3gg 165.141 47.453 1.00 33.48 D
ATOM 7462 C GLN 611 33.37g 163.730 50.380 1.00 33.48 D
ATOM 7463 O GLN 611 34.2g5 164.511 50.621 1.00 33.48 D
ATOM 7464 N LEU 612 32.975 162.815 51.250 1.00 33.48 D
ATOM 7465 CA LEU 612 33.611 162.673 52.558 1.00 33.4δ D
ATOM 7466 CB LEU 612 33.070 161.425 53.255 1.00 33.4δ D
ATOM 7467 CG LEU 612 31.595 161.580 53.635 1.00 33.4δ D
ATOM 746δ CDl LEU 612 30.989 160.240 54.044 1.00 33.4δ D
ATOM 7469 CD2 LEU 612 31.501162.608 54.75g 1.00 33.48 D
ATOM 7470 C LEU 612 35.137 162. sgδ 52.456 1.00 33.48 D
ATOM 7471 O LEU 612 35.862 163.343 53.12δ 1.00 33.48 D
ATOM 7472 N ALA 613 35.616 161.6g3 51.613 1.00 33.48 D
ATOM 7473 CA ALA 613 37.044 161.531 51.407 1.00 33.48 D
ATOM 7474 CB ALA 613 37.296 160.68g 50.172 1.00 33.48 D ATOM 7475 C ALA 613 37.602 162,,922 51,.204 1.0033,,4δ D
ATOM 7476 O ALA 613 . 3δ.7l9 163, ,246 51, .613 1.00 33 .4δ D
ATOM 7477 N GLU 614 36.786 163, ,75δ 50, .586 1.00 33, ,4δ D
ATOM 747δ CA GLU 614 37.176 165, .124 50, .294 1.00 3 .4δ D
ATOM 7479 CB GLU 614 36.224 165. ,691 49. .253 1.00 33, ,4δ D
ATOM 7480 CG GLU 614 36.758 166, ,δl6 48, .432 1.00 33 .4δ D
ATOM 7481 CD GLU 614 35.864 167, ,049 47, .239 1.00 33, ,4δ D
ATOM 7482 OEl GLU 614 34.772 167, ,660 47, .415 1.00 33 .4δ D
ATOM 74δ3 OE2 GLU 614 36.241 166. ,586 46, ,131 1.00 33, ,4δ D
ATOM 7484 C GLU 614 37.207 166. ,029 51, .520 1.00 33 .48 D
ATOM 7485 O GLU 614 38.165 166. ,791 51, .704 1.00 33, .48 D
ATOM 7486 N ILE 615 36.179 165. ,945 52, .365 1.00 33, .4δ D
ATOM 74δ7 CA ILE 615 36.147 166. ,817 53. ,532 1.00 33, .48 D
ATOM 7488 CB ILE 615 35.041 166, .442 54. .532 1.00 33, .48 D
ATOM 7489 CG2 ILE 615 35.132 167. ,332 55. .761 1.00 33, .48 D
ATOM 7490 CGl ILE 615 33.669 166, ,681 53. .918 1.00 33, .4δ D
ATOM 7491 CDl ILE 615 32.573 166. ,604 54. .931 1.00 33, .4δ D
ATOM 7492 C ILE 615 37.4δ2 166, ,825 54. .252 1.00 33 .4δ D
ATOM 7493 O ILE 615 37.δ96 167. ,856 54. .780 1.00 33, .4δ D
ATOM 7494 N ALA 616 38.160 165. .684 54. .262 1.00 33 .48 D
ATOM 7495 CA ALA 616 3g.469 165. ,594 54, ,910 1.00 33, .48 D
ATOM 7496 CB ALA 616 40.213 164. .346 54, ,418 1.00 33 .48 D
ATOM 7497 C ALA 616 40.330 166. .856 54, .650 1.00 33, .48 D
ATOM 7498 0 ALA 616 40.203 167, .864 55, .368 1.00 33 .48 D
ATOM 749g N GLU 617 41.190 166. .795 53, .628 1.00 33, .48 D
ATOM 7500 CA GLU 617 42.069 167. .913 53, .293 1.00 33 .48 D
ATOM 7501 CB GLU 617 42.407 167. .927 51, ,800 1.00 33, .4δ D
ATOM 7502 CG GLU 617 43.562 167, ,020 51, .416 1.00 33, .4δ D
ATOM 7503 CD GLU 617 43.230 165. ,541 51. ,591 1.00 33, ,4δ D
ATOM 7504 OEl GLU 617 44.170 164. .711 51, ,488 1.00 33, .4δ D
ATOM 7505 OE2 GLU 617 42.033 165. .216 51. ,823 1.00 33, .48 D
ATOM 7506 C GLU 617 41.486 169. ,25g 53. ,682 1.00 33, .48 D
ATOM 7507 0 GLU 617 42.170 170. .063 54. ,323 1.00 33, .48 D
ATOM 7508 N SER 618 40.235 169, .518 53. ,302 1.00 33, .48 D
ATOM 750g CA SER 618 39.615 170. ,7g4 53. ,652 1.00 33, .48 D
ATOM 7510 CB SER 618 38.354 171, .055 52, ,800 1.00 33 .48 D
ATOM 7511 OG SER 618 37.259 170. .215 53. ,156 1.00 33, .4δ D
ATOM 7512 C SER 618 39.265 170. .775 55. ,142 1.00 33 .4δ D
ATOM 7513 0 SER 618 3δ.053 170. .668 55. ,481 1.00 33 .4δ D
ATOM 7514 OXT SER 618 40.226 170. .848 55. ,951 1.00 33 .4δ D
TER 7515 SER 618 D
ATOM 7516 C GLY 354 158.351 49. .635 57. ,068 1.00 33 .4δ E
ATOM 7517 0 GLY 354 157.462 50. ,026 57. ,825 1.00 33, .48 E
ATOM 7518 N GLY 354 158.506 47. ,241 56. ,26δ 1.00 33, .48 E ATOM 75ig CA GLY 354 159.,000 48.269 57,.245 1.00 33,.48 E
ATOM 7520 N LYS 355 158. ,817 50.373 56, ,072 1.00 33, .48 E
ATOM 7521 CA LYS 355 158. ,272 51.684 55, .771 1.00 33, .48 E
ATOM 7522 CB LYS 355 159. ,186 52.384 54. .766 1.00 33, .48 E
ATOM 7523 CG LYS 355 159. ,808 51.462 53. .732 1.00 33, .48 E
ATOM 7524 CD LYS 355 160. ,964 52.153 53. .020 1.00 33, .48 E
ATOM 7525 CE LYS 355 161. ,592 51.258 51. .950 1.00 33, .48 E
ATOM 7526 NZ LYS 355 162. ,452 50.157 52, ,477 1.00 33, .48 E
ATOM 7527 C LYS 355 156, ,854 51.554 55, .208 1.00 33, .48 E
ATOM 7528 O LYS 355 156. ,141 52.554 55, .022 1.00 33, .48 E
ATOM 752g N TRP 356 156. ,455 50.304 54, .951 1.00 33 .48 E
ATOM 7530 CA TRP 356 155, ,135 49.ggδ 54, .401 1.00 33, .48 E
ATOM 7531 CB TRP 356 155, .240 4δ.goδ 53, .333 1.00 33 .48 E
ATOM 7532 CG TRP 356 156, .031 4g.326 52, .135 1.00 33, .48 E
ATOM 7533 CD2 TRP 356 155, ,575 50.131 51, ,036 1.00 33, .48 E
ATOM 7534 CE2 TRP 356 156, .658 50.282 50, .150 1.00 33, .48 E
ATOM 7535 CE3 TRP 356 154, ,357 50.742 50, .720 1.00 33, .48 E
ATOM 7536 CDl TRP 356 157, ,337 4g.035 51, .875 1.00 33, .48 E
ATOM 7537 NEl TRP 356 157, ,723 4g.602 50, .681 1.00 33, .48 E
ATOM 7538 CZ2 TRP 356 156, .561 5i.oιg 48, .969 1.00 33, .48 E
ATOM 753g CZ3 TRP 356 154, .263 51.471 49. ,551 1.00 33, .48 E
ATOM 7540 CH2 TRP 356 155, .359 51.604 48. ,6δ9 1.00 33, .48 E
ATOM 7541 C TRP 356 154, .170 4g.550 55. ,4δl 1.00 33, .48 E
ATOM 7542 O TRP 356 152, ,9δg 4g.316 55, ,212 1.00 33, .48 E
ATOM 7543 N VAL 357 154, ,6δ5 4g.457 56. ,705 1.00 33, .48 E
ATOM 7544 CA VAL 357 153, ,go6 4g.021 57. ,δ56 1.00 33, .48 E
ATOM 7545 CB VAL 357 154, ,7g6 48.715 sg. ,048 1.00 33, .48 E
ATOM 7546 CGl VAL 357 153, ,g36 48.434 60. .247 1.00 33, .48 E
ATOM 7547 CG2 VAL 357 155, ,6g6 47.540 58. ,738 1.00 33, .48 E
ATOM 7548 C VAL 357 152, .882 50.014 58. ,342 1.00 33, .48 E
ATOM 754g O VAL 357 153, .228 51.0δ4 5δ. .828 1.00 33, .48 E
ATOM 7550 N ILE 358 151, ,617 4g.64g 5δ. .222 1.00 33, .48 E
ATOM 7551 CA ILE 358 150, .539 50.504 58, .678 1.00 33, .48 E
ATOM 7552 CB ILE 358 149, .363 50.43δ 57, .712 1.00 33, .48 E
ATOM 7553 CG2 ILE 358 148, .086 50.78g 58, .433 1.00 33, .48 E
ATOM 7554 CGl ILE 358 149, ,639 51.344 56, ,515 1.00 33, .48 E
ATOM 7555 CDl ILE 358 148, .440 51.57g 55, .621 1.00 33, .48 E
ATOM 7556 C ILE 358 150, .096 50.048 60, ,072 1.00 33, .48 E
ATOM 7557 O ILE 358 150, .167 48.864 60, ,398 1.00 33, .48 E
ATOM 7558 N ASP 359 149. ,656 50.984 60. ,903 1.00 33, .48 E
ATOM 7559 CA ASP 359 149. .219 50.635 62. ,250 1.00 33, .48 E
ATOM 7560 CB ASP 359 149. ,778 51.598 63. ,282 1.00 33, .48 E
ATOM 7561 CG ASP 359 148, ,968 51.5δδ 64. .550 1.00 33, .48 E
ATOM 7562 ODl ASP 359 148, ,812 50.4δ5 65. .123 1.00 33, .48 E ATOM 7563 OD2 ASP 359 148.477 52,,667 64.,961 1.0033,.48 E
ATOM 7564 C ASP 359 147.720 50, ,663 62, ,370 1.00 33, .48 E
ATOM 7565 0 ASP 359 147.088 51, ,706 62, ,180 1.00 33, .48 E
ATOM 7566 N PRO 360 147.124 49. ,522 62. ,730 1.00 33, .48 E
ATOM 7567 CD PRO 360 147.772 48. ,241 63. ,058 1.00 33, .48 E
ATOM 7568 CA PRO 360 145.668 49. ,433 62. ,870 1.00 33, .48 E
ATOM 756g CB PRO 360 145.468 48. ,043 63. ,456 1.00 33, .48 E
ATOM 7570 CG PRO 360 146.643 47. ,263 62, ,847 1.00 33, .48 E
ATOM 7571 C PRO 360 145.124 50. ,543 63. ,758 1.00 33, .48 E
ATOM 7572 0 PRO 360 145.890 51. ,378 64. ,253 1.00 33, .48 E
ATOM 7573 N SER 361 143.806 50. ,558 63. ,93δ 1.00 33, .48 E
ATOM 7574 CA SER 361 143.130 51. .563 64. ,764 1.00 33, .48 E
ATOM 7575 CB SER 361 143.864 51. ,7g2 66. ,og7 1.00 33 .48 E
ATOM 7576 OG SER 361 144.944 52. ,716 65. ,g49 1.00 33, .48 E
ATOM 7577 C SER 361 143.114 52, ,866 63. ,9gδ 1.00 33, .48 E
ATOM 7578 0 SER 361 142.207 53, ,6 6 64. ,156 1.00 33, .48 E
ATOM 757g N GLU 362 144.141 53, .045 63, .178 1.00 33 .48 E
ATOM 7580 CA GLU 362 144.260 54, .244 62, ,381 1.00 33 .48 E
ATOM 7581 CB GLU 362 145.735 54, .4 6 62, .082 1.00 33 .48 E
ATOM 7582 CG GLU 362 146.581 54, .485 63, ,35δ 1.00 33, .48 E
ATOM 7583 CD GLU 362 147.970 55, .055 63, ,163 1.00 33 .48 E
ATOM 75δ4 OEl GLU 362 148.853 54, .345 62, ,62δ 1.00 33 .48 E
ATOM 7585 OE2 GLU 362 148.170 56, .227 63, ,545 1.00 33 .48 E
ATOM 7586 C GLU 362 143.453 53, .g52 61, ,136 1.00 33 .48 E
ATOM 7587 0 GLU 362 142. δ s 54, .856 60. ,501 1.00 33, .48 E
ATOM 758δ N LEU 363 143.380 52, ,65g 60. ,818 1.00 33, .48 E
ATOM 75δg CA LEU 363 142.612 52, .170 59. ,675 1.00 33, .48 E
ATOM 75go CB LEU 363 143.036 50, .760 59. ,303 1.00 33 .48 E
ATOM 75gi CG LEU 363 143.690 50, .614 57. ,g3δ 1.00 33 .48 E
ATOM 7592 CDl LEU 363 144.046 49, .128 57. ,6δ6 1.00 33, .48 E
ATOM 7593 CD2 LEU 363 142.744 51, .146 56. ,δ83 1.00 33 .48 E
ATOM 75g4 C LEU 363 141.156 52, .138 60, ,105 1.00 33 .48 E
ATOM 75g5 0 LEU 363 140.837 51, ,gg4 61, ,2go 1.00 33 .48 E
ATOM 75g6 N THR 364 140.258 52, .282 59, ,152 1.00 33 .48 E
ATOM 75g7 CA THR 364 13δ.δ67 52 .263 59, .508 1.00 33 .48 E
ATOM 75g8 CB THR 364 138.391 53, .638 60, ,008 1.00 33 .48 E
ATOM 7599 OGl THR 364 137.405 54, .157 59, ,110 1.00 33 .48 E
ATOM 7600 CG2 THR 364 139.571 54, .610 60, ,124 1.00 33 .48 E
ATOM 7601 C THR 364 138.054 51, .843 58, .318 1.00 33 .48 E
ATOM 7602 0 THR 364 137.962 52, .558 57, ,32g 1.00 33 .48 E
ATOM 7603 N PHE 365 137.475 50, ,655 58, ,428 1.00 33 .48 E
ATOM 7604 CA PHE 365 136.654 50, .105 57. ,380 1.00 33 .48 E
ATOM 7605 CB PHE 365 136.442 48, .628 57. ,641 1.00 33 .48 E
ATOM 7606 CG PHE 365 137.718 47, .855 57. ,732 1.00 33 .48 E ATOM 7607 CDl PHE 365 138.121 47.,040 56.,698 1.00 33,,48 E
ATOM 760δ CD2 PHE 365 138.52δ 47. ,968 58. ,847 1.00 33. .48 E
ATOM 760g CEl PHE 365 139.301 46. ,356 56. .777 1.00 33. .48 E
ATOM 7610 CE2 PHE 365 139.716 47. ,284 58. .932 1.00 33. .48 E
ATOM 7611 CZ PHE 365 140.104 46. ,477 57. ,89g 1.00 33. .48 E
ATOM 7612 C PHE 365 135.344 50. ,845 57. .416 1.00 33. .48 E
ATOM 7613 O PHE 365 134.7δ 51. ,070 58. .485 1.00 33. .48 E
ATOM 7614 N VAL 366 134. δ6δ 51. ,251 56, ,24g 1.00 33, .48 E
ATOM 7615 CA VAL 366 133.612 51. ,962 56, ,156 1.00 33, .48 E
ATOM 7616 CB VAL 366 133.753 53. ,164 55, .245 1.00 33, .48 E
ATOM 7617 CGl VAL 366 132.406 53. ,850 55, .072 1.00 33, .48 E
ATOM 761δ CG2 VAL 366 134.787 54. ,110 55, .834 1.00 33, .48 E
ATOM 76ig C VAL 366 132.538 51. ,035 55, .sgs 1.00 33, .48 E
ATOM 7620 O VAL 366 131.367 51. ,118 55, .ggs 1.00 33, .48 E
ATOM 7621 N GLN 367 132.945 50, .152 54, .681 1.00 33, .48 E
ATOM 7622 CA GLN 367 132.034 49. .195 54, .055 1.00 33, .48 E
ATOM 7623 CB GLN 367 130.855 49. ,92g 53, .431 1.00 33, .48 E
ATOM 7624 CG GLN 367 131.089 50. ,416 52, ,02g 1.00 33, .48 E
ATOM 7625 CD GLN 367 130.125 51. .519 51, .653 1.00 33, .48 E
ATOM 7626 OEl GLN 367 130.189 52, ,622 52, .203 1.00 33, .48 E
ATOM 7627 NE2 GLN 367 12g.214 51, .232 50, .724 1.00 33, .48 E
ATOM 762δ C GLN 367 132.723 48. .371 52, ,g77 1.00 33, .48 E
ATOM 762g O GLN 367 133.377 48. .916 52, ,og5 1.00 33, .48 E
ATOM 7630 N GLU 368 132.586 47. .053 53. .052 1.00 33, .48 E
ATOM 7631 CA GLU 368 133.179 46, .184 52. .045 1.00 33, .48 E
ATOM 7632 CB GLU 368 132. g24 44, ,719 52, .383 1.00 33, .48 E
ATOM 7633 CG GLU 368 131.434 44, ,389 52, .434 1.00 33, .48 E
ATOM 7634 CD GLU 368 131.119 42, .943 52, .071 1.00 33, .48 E
ATOM 7635 OEl GLU 368 131.348 42, .538 50, .goo 1.00 33, .48 E
ATOM 7636 OE2 GLU 36δ 130.634 42, .212 52, ,g65 1.00 33 .48 E
ATOM 7637 C GLU 368 132.474 46, .516 50, .736 1.00 33 .48 E
ATOM 763δ O GLU 368 131.311 46, .927 50, .73g 1.00 33 .48 E
ATOM 763g N ILE 369 133.179 46. .333 49. .622 1.00 33, .48 E
ATOM 7640 CA ILE 369 132.621 46, ,618 48, .304 1.00 33, .48 E
ATOM 7641 CB ILE 369 133.044 48, ,032 47, .834 1.00 33, .48 E
ATOM 7642 CG2 ILE 369 132.4δ3 49, ,089 48, ,7δ2 1.00 33, .48 E
ATOM 7643 CGl ILE 369 134.572 48, ,115 47, .759 1.00 33, .48 E
ATOM 7644 CDl ILE 369 135.109 49, ,512 47, .576 1.00 33, .48 E
ATOM 7645 C ILE 369 133.034 45, .577 47, .242 1.00 33, .48 E
ATOM 7646 O ILE 369 132.766 45, .750 46, .044 1.00 33, .48 E
ATOM 7647 N GLY 370 133.668 44, ,4g2 47, .672 1.00 33 .48 E
ATOM 7648 CA GLY 370 134.077 43, ,485 46, .712 1.00 33 .48 E
ATOM 764g C GLY 370 134.746 42, ,2δ6 47, .353 1.00 33 .48 E
ATOM 7650 O GLY 370 135.961 42. ,2δ0 47, ,588 1.00 33, .48 E ATOM 7651 N SER 371 133.945 41.257 47.622 1.00 33..48 E
ATOM 7652 CA SER 371 134.441 40.043 48.253 1.00 33, .48 E
ATOM 7653 CB SER 371 133.331 39.372 4g.070 1.00 33, .48 E
ATOM 7654 OG SER 371 133.837 38.271 4g.813 1.00 33, .48 E
ATOM 7655 C SER 371 134.940 39.084 47.195 1.00 33, .48 E
ATOM 7656 O SER 371 135.002 39.432 46.007 1.00 33, .48 E
ATOM 7657 N GLY 372 135.29δ 37.880 47.634 1.00 33, .48 E
ATOM 7658 CA GLY 372 135.784 36.876 46.712 1.00 33, .48 E
ATOM 765g C GLY 372 136.516 35.706 47.343 1.00 33, .48 E
ATOM 7660 O GLY 372 136.855 35.704 48.529 1.00 33, .48 E
ATOM 7661 N GLN 373 136.755 34.696 46.5ig 1.00 33, .48 E
ATOM 7662 CA GLN 373 137.458 33.503 46.g36 1.00 33, .48 E
ATOM 7663 CB GLN 373 137.709 32.633 45.698 1.00 33, .48 E
ATOM 7664 CG GLN 373 138.344 31.264 45.9ig 1.00 33, .48 E
ATOM 7665 CD GLN 373 138.601 30.537 44.587 1.00 33, .48 E
ATOM 7666 OEl GLN 373 139.100 29.395 44.561 1.00 33, .48 E
ATOM 7667 NE2 GLN 373 138.262 31.203 43.470 1.00 33, .48 E
ATOM 7668 C GLN 373 13δ.775 33.920 47.595 1.00 33 .48 E
ATOM 766g O GLN 373 139.370 33.140 48.337 1.00 33 .48 E
ATOM 7670 N PHE 374 139.215 35.153 47.328 1.00 33, .48 E
ATOM 7671 CA PHE 374 140.471 35.690 47.δ86 1.00 33, .48 E
ATOM 7672 CB PHE 374 141. Oδδ 36.742 46.954 1.00 33, .48 E
ATOM 7673 CG PHE 374 140.903 38.169 47.452 1.00 33, .48 E
ATOM 7674 CDl PHE 374 141.637 38.647 48.538 1.00 33 .48 E
ATOM 7675 CD2 PHE 374 139. g24 38.9g4 46.900 1.00 33, .48 E
ATOM 7676 CEl PHE 374 141.392 3g.8 7 49.062 1.00 33, .48 E
ATOM 7677 CE2 PHE 374 139.673 40.260 47.425 1.00 33, .48 E
ATOM 7678 CZ PHE 374 140.405 40.70g 48.508 1.00 33, .48 E
ATOM 767g C PHE 374 140.198 36.3gδ 49.206 1.00 33, .48 E
ATOM 7680 O PHE 374 140.927 36.241 50.206 1.00 33, .48 E
ATOM 7681 N GLY 375 139.160 37.227 49.159 1.00 33, .48 E
ATOM 7682 CA GLY 375 138.754 38.021 50.298 1.00 33, .48 E
ATOM 7683 C GLY 375 137. δ74 39.117 49.739 1.00 33, .48 E
ATOM 7684 O GLY 375 137.374 39.004 48.610 1.00 33 .48 E
ATOM 7685 N LEU 376 137.691 40.181 50.511 1.00 33 .48 E
ATOM 7686 CA LEU 376 136. 64 41.284 50.065 1.00 33 .48 E
ATOM 7687 CB LEU 376 135.712 41.522 51.041 1.00 33 .48 E
ATOM 7688 CG LEU 376 135.113 40.29g 51.734 1.00 33 .48 E
ATOM 768g CDl LEU 376 136.155 3g.746 52.702 1.00 33 .48 E
ATOM 7690 CD2 LEU 376 133.814 40.6δ3 52.486 1.00 33 .48 E
ATOM 7691 C LEU 376 137.686 42.558 49.g36 1.00 33, .48 E
ATOM 7692 0 LEU 376 13δ.924 42.531 49.9g7 1.00 33, .48 E
ATOM 7693 N VAL 377 136.974 43.670 49.762 1.00 33 .48 E
ATOM 7694 CA VAL 377 137.588 44.g78 49.609 1.00 33, .48 E ATOM 7695 CB VAL 377 137. δ3δ 45.,301 48.,132 1.00 33.,48 E
ATOM 7696 CGl VAL 377 13δ.l77 46. ,773 47. ,9δ4 1.00 33. .48 E
ATOM 76g7 CG2 VAL 377 138.974 44, ,43g 47. ,5g6 1.00 33. .48 E
ATOM 76gδ C VAL 377 136.681 46, .063 50. ,163 1.00 33. .48 E
ATOM 76gg O VAL 377 135.705 46. .452 49. sog 1.00 33. ,48 E
ATOM 7700 N HIS 378 137.001 46. .547 51. ,362 1.00 33. ,48 E
ATOM 7701 CA HIS 378 136.211 47. .602 51. ,gδg 1.00 33. .48 E
ATOM 7702 CB HIS 378 136.356 47. .591 53. ,510 1.00 33, .48 E
ATOM 7703 CG HIS 378 135.675 46, .445 54. .182 1.00 33, .48 E
ATOM 7704 CD2 HIS 378 134.562 46, .401 54. .951 1.00 33, .48 E
ATOM 7705 NDl HIS 378 136.147 45, .151 54. ,109 1.00 33, .48 E
ATOM 7706 CEl HIS 378 135.352 44, .359 54. ,806 1.00 33, .48 E
ATOM 7707 NE2 HIS 378 134.383 45, .092 55. ,326 1.00 33, .48 E
ATOM 770δ C HIS 378 136.669 48, ,95g 51. ,505 1.00 33, .48 E
ATOM 770g 0 HIS 378 137.759 49. ,og4 50. ,935 1.00 33, .48 E
ATOM 7710 N LEU 37 135.818 49. ,g53 51. ,773 1.00 33, .48 E
ATOM 7711 CA LEU 37 136.043 51, ,353 51. ,430 1.00 33, .48 E
ATOM 7712 CB LEU 37g 134.727 52, ,114 51. ,491 1.00 33, ,48 E
ATOM 7713 CG LEU 37g 134.805 53, ,573 51. ,076 1.00 33, .48 E
ATOM 7714 CDl LEU 379 135.381 53, ,640 49. ,695 1.00 33, .48 E
ATOM 7715 CD2 LEU 379 133.431 54, .213 51. ,101 1.00 33, .48 E
ATOM 7716 C LEU 379 137.005 51, ,g36 52. ,450 1.00 33, .48 E
ATOM 7717 0 LEU 379 138.157 52, .236 52. ,128 1.00 33, .48 E
ATOM 771δ N GLY 380 136.521 52, .088 53. ,683 1.00 33, .48 E
ATOM 77ig CA GLY 380 137.338 52, ,62g 54. ,765 1.00 33, .48 E
ATOM 7720 C GLY 380 138.265 53, ,82g 54. ,512 1.00 33, .48 E
ATOM 7721 0 GLY 380 138.118 54, .585 53. ,531 1.00 33, .48 E
ATOM 7722 N TYR 381 139.214 54, .027 55. ,432 1.00 33, .48 E
ATOM 7723 CA TYR 381 140.183 55, .105 55. ,305 1.00 33, .48 E
ATOM 7724 CB TYR 381 139.4 4 56, .460 55. ,298 1.00 33, .48 E
ATOM 7725 CG TYR 381 138.291 56, .603 56. ,171 1.00 33, .48 E
ATOM 7726 CDl TYR 381 137.059 56, ,g98 55. ,622 1.00 33, .48 E
ATOM 7727 CEl TYR 381 135.971 57, .318 56. ,432 1.00 33, .48 E
ATOM 772δ CD2 TYR 381 138.401 56, .510 57. ,551 1.00 33, .48 E
ATOM 772g CE2 TYR 381 137.322 56, .831 58. ,381 1.00 33, .48 E
ATOM 7730 CZ TYR 3δl 136.115 57, .239 57. ,816 1.00 33, .48 E
ATOM 7731 OH TYR 3δl 135.0δ4 57, .613 58. ,648 1.00 33, .48 E
ATOM 7732 C TYR 381 141.364 55, .118 56. ,267 1.00 33, .48 E
ATOM 7733 0 TYR 381 141.501 54, .251 57. ,129 1.00 33, .48 E
ATOM 7734 N TRP 382 142.226 56, .117 56. ,118 1.00 33, .48 E
ATOM 7735 CA TRP 382 143.431 56, .165 56. ,931 1.00 33, .48 E
ATOM 7736 CB TRP 382 144.483 55, .370 56. ,170 1.00 33, .48 E
ATOM 7737 CG TRP 382 145.838 55, .367 56. ,705 1.00 33 .48 E
ATOM 7738 CD2 TRP 382 147.040 55, ,441 55. ,937 1.00 33, ,48 E ATOM 773g CE2 TRP 382 148. Ill 55.,254 56.,821 1.00 33, 48 E
ATOM 7740 CE3 TRP 3δ2 147.312 55. ,641 54. ,579 1.00 33. ,48 E
ATOM 7741 CDl TRP 3δ2 146.212 55. ,156 57. ,9go 1.00 33. ,48 E
ATOM 7742 NEl TRP 3δ2 147.581 55. ,083 58. ,073 1.00 33. .48 E
ATOM 7743 CZ2 TRP 3δ2 14g.433 55. ,261 56. ,3g4 1.00 33. .48 E
ATOM 7744 CZ3 TRP 3δ2 148.621 55. ,647 54. .159 1.00 33. .48 E
ATOM 7745 CH2 TRP 3δ2 14g.665 55. ,458 55. ,061 1.00 33. .48 E
ATOM 7746 C TRP 3δ2 143. 43 57. ,563 57. ,309 1.00 33. ,48 E
ATOM 7747 O TRP 3δ2 143.894 58. ,507 56. ,519 1.00 33. ,48 E
ATOM 774δ N LEU 383 144.430 57. ,674 58. ,538 1.00 33. ,48 E
ATOM 774g CA LEU 383 144.956 58. .918 59. ,078 1.00 33. ,48 E
ATOM 7750 CB LEU 383 146.344 59. ,181 58. ,514 1.00 33. ,48 E
ATOM 7751 CG LEU 383 147.357 58. .107 58. ,890 1.00 33. .48 E
ATOM 7752 CDl LEU 383 148.741 58, ,495 58. ,39g 1.00 33, .48 E
ATOM 7753 CD2 LEU 383 147.341 57, .937 60. .391 1.00 33, .48 E
ATOM 7754 C LEU 383 144.065 60. .136 58. ,856 1.00 33, .48 E
ATOM 7755 O LEU 383 144.2δδ 61, ,181 59. ,462 1.00 33, .48 E
ATOM 7756 N ASN 384 143.040 60, ,000 58. ,022 1.00 33, .48 E
ATOM 7757 CA ASN 384 142.144 61, ,114 57. ,760 1.00 33, .48 E
ATOM 775δ CB ASN 384 142.950 62, .291 57, .269 1.00 33, .48 E
ATOM 775g CG ASN 384 143.552 62, .021 55, .936 1.00 33, .48 E
ATOM 7760 ODl ASN 3δ4 142. δ90 62, .203 54, .919 1.00 33, .48 E
ATOM 7761 ND2 ASN 3δ4 144.7gδ 61, .545 55, .917 1.00 33, .48 E
ATOM 7762 C ASN 3δ4 141.089 60, .726 56. ,717 1.00 33, .48 E
ATOM 7763 O ASN 3δ4 141.280 59. .796 55. ,930 1.00 33, .48 E
ATOM 7764 N LYS 385 140.002 61. .481 56. ,684 1.00 33, .48 E
ATOM 7765 CA LYS 385 13δ.880 61. .187 55. ,820 1.00 33, .48 E
ATOM 7766 CB LYS 385 137.715 62, .098 56. ,229 1.00 33, .48 E
ATOM 7767 CG LYS 385 136.935 61, .532 57, ,431 1.00 33, .48 E
ATOM 776δ CD LYS 385 136.35δ 62, .618 58, .326 1.00 33, .48 E
ATOM 776g CE LYS 385 137.471 63, .366 59, .066 1.00 33, .48 E
ATOM 7770 NZ LYS 385 136.957 64, .563 59. .809 1.00 33, .48 E
ATOM 7771 C LYS 385 13δ.953 61, .080 54. .290 1.00 33, .48 E
ATOM 7772 O LYS 385 137.939 61, .287 53, ,605 1.00 33, .48 E
ATOM 7773 N ASP 386 140.106 60, .766 53, .716 1.00 33, .48 E
ATOM 7774 CA ASP 386 140.074 60, .591 52, .271 1.00 33 .48 E
ATOM 7775 CB ASP 3δ6 141.107 61, .468 51, .504 1.00 33 .48 E
ATOM 7776 CG ASP 3δ6 142.466 61, .517 52, ,150 1.00 33 .48 E
ATOM 7777 ODl ASP 3δ6 143.356 62, .167 51, .569 1.00 33 .48 E
ATOM 7778 OD2 ASP 3δ6 142.646 60, .911 53, .224 1.00 33, .48 E
ATOM 7779 C ASP 3δ6 140.218 59, .104 51. ,98g 1.00 33, .48 E
ATOM 7780 O ASP 3δ6 141.070 58, .413 52, ,56δ 1.00 33, .48 E
ATOM 7781 N LYS 3δ7 139.329 58, .630 51. ,120 1.00 33, .48 E
ATOM 7782 CA LYS 3δ7 139. ιg2 57, .225 50. ,731 1.00 33, .48 E ATOM 7783 CB LYS 387 13δ.l59 57.104 49.,609 1.00 33.48 E
ATOM 7784 CG LYS 387 136. 26 57.745 49. ,918 1.00 33.48 E
ATOM 7785 CD LYS 387 135.963 57.785 48. ,694 1.00 33.48 E
ATOM 7786 CE LYS 387 134. δ90 58.δ37 48. ,843 1.00 33.48 E
ATOM 7787 NZ LYS 387 134.050 5δ.951 47. ,609 1.00 33.48 E
ATOM 7788 C LYS 3δ7 140.405 56.422 50. ,330 1.00 33.48 E
ATOM 778g 0 LYS 387 141.270 56.δ76 49. ,593 1.00 33.48 E
ATOM 77go N VAL 38δ 140.446 55.ig6 50. ,813 1.00 33.48 E
ATOM 77gi CA VAL 3δδ 141.524 54.2gi 50. ,478 1.00 33.48 E
ATOM 7792 CB VAL 3δδ 142.483 54.146 51. ,633 1.00 33.48 E
ATOM 7791 CGl VAL 388 143.175 55.463 51. ,8δ5 1.00 33.48 E
ATOM 7794 CG2 VAL 388 141.724 53.712 52. ,δ52 1.00 33.48 E
ATOM 7795 C VAL 38δ 140.871 52.g47 50. ,178 1.00 33.48 E
ATOM 7796 0 VAL 3δδ 13g.653 52.7g5 50. ,311 1.00 33.4δ E
ATOM 7797 N ALA 3δg 141.666 51.973 49. ,762 1.00 33.48 E
ATOM 7798 CA ALA 3δg 141.117 50.675 49. ,429 1.00 33.48 E
ATOM 779g CB ALA 3δg 141.324 50.380 47. ,960 1.00 33.48 E
ATOM 7800 C ALA 3δg 141.751 4g.sg3 50. ,262 1.00 33.48 E
ATOM 7801 0 ALA 3δg 142.886 49.184 49. ,9g3 1.00 33.48 E
ATOM 7802 N ILE 3go 141.031 49.144 51. ,2gι 1.00 33.4δ E
ATOM 7803 CA ILE 3go 141.545 48.067 52. ,129 1.00 33.4δ E
ATOM 7804 CB ILE 3go 140. g4δ 48.076 53. ,551 1.00 33.4δ E
ATOM 7805 CG2 ILE 390 141.780 47.162 54. ,454 1.00 33.48 E
ATOM 7806 CGl ILE 390 140.970 49.48g 54. ,136 1.00 33.48 E
ATOM 7δ07 CDl ILE 390 140.236 4g .612 55. ,466 1.00 33.4δ E
ATOM 7δ0δ C ILE 390 141.159 46.775 51. ,427 1.00 33.48 E
ATOM 7δog 0 ILE 390 140.037 46.637 50. ,8gδ 1.00 33.48 E
ATOM 7δl0 N LYS 391 142.078 45.827 51. ,407 1.00 33.48 E
ATOM 7811 CA LYS 391 141.841 44.577 50. ,73δ 1.00 33.48 E
ATOM 7812 CB LYS 391 142.575 44.566 49. ,38g 1.00 33.48 E
ATOM 7813 CG LYS 391 142.060 43.558 48. ,341 1.00 33.48 E
ATOM 7814 CD LYS 391 143.158 43.247 47. ,301 1.00 33.48 E
ATOM 7815 CE LYS 391 142.921 43.884 45. .918 1.00 33.48 E
ATOM 7816 NZ LYS 391 144.056 43.661 44, ,g70 1.00 33.48 E
ATOM 7817 C LYS 391 142.307 43.412 51. ,5g4 1.00 33.48 E
ATOM 7818 0 LYS 391 143.389 43.445 52. ,203 1.00 33.48 E
ATOM 78ig N THR 392 141.466 42.384 51. ,621 1.00 33.48 E
ATOM 7δ20 CA THR 392 141.762 41.166 52. ,346 1.00 33.48 E
ATOM 7δ21 CB THR 392 141.892 41.435 53. ,843 1.00 33.4δ E
ATOM 7δ22 OGl THR 392 142.216 40.206 54. ,503 1.00 33.4δ E
ATOM 7δ23 CG2 THR 392 140.594 42.032 54. ,400 1.00 33.48 E
ATOM 7δ24 C THR 3g2 140.635 40.173 52. ,085 1.00 33.48 E
ATOM 7δ25 0 THR 3g2 139.7δ3 40.421 51. ,229 1.00 33.48 E
ATOM 7δ26 N GLU 405 154.417 38.101 47. ,912 1.00 33.48 E ATOM 7827 CA GLU 405 153.586 37,.965 46,.712 1.00 33,,4δ E
ATOM 7828 CB GLU 405 152.352 37, ,09g 46, ,ggι 1.00 33, .4δ E
ATOM 7829 CG GLU 405 152.681 35, .6g4 47, .467 1.00 33, .48 E
ATOM 7830 CD GLU 405 153.846 35, .iog 46, ,6g4 1.00 33, .48 E
ATOM 7831 OEl GLU 405 153.770 35, .131 45, .441 1.00 33, .48 E
ATOM 7832 OE2 GLU 405 154.828 34, .643 47, .330 1.00 33, .48 E
ATOM 7833 C GLU 405 153.121 39, ,318 46, .198 1.00 33, .48 E
ATOM 7834 0 GLU 405 153.926 40, .125 45, .716 1.00 33, .48 E
ATOM 7835 N GLU 406 151.821 39, .572 46, .324 1.00 33, .48 E
ATOM 7836 CA GLU 406 151.237 40, ,817 45, .848 1.00 33, .48 E
ATOM 7δ37 CB GLU 406 149.788 40, ,g3i 46, .328 1.00 33, .48 E
ATOM 7838 CG GLU 406 148.947 41, .853 45, .455 1.00 33, .48 E
ATOM 7839 CD GLU 406 147.478 41, ,87g 45, .849 1.00 33, .48 E
ATOM 7840 OEl GLU 406 146.666 42, .504 45, ,116 1.00 33, .48 E
ATOM 7841 OE2 GLU 406 147.133 41, ,27δ 46, .894 1.00 33, .48 E
ATOM 7δ42 C GLU 406 152.033 42, .077 46, .243 1.00 33 .48 E
ATOM 7δ43 0 GLU 406 152.820 42, .614 45, ,441 1.00 33, .48 E
ATOM 7δ44 N ALA 407 151.829 42, .550 47, ,470 1.00 33, .48 E
ATOM 7δ45 CA ALA 407 152.527 43, .743 47, ,947 1.00 33 .48 E
ATOM 7846 CB ALA 407 152.381 43, ,δ67 4g. ,460 1.00 33, ,48 E
ATOM 7847 C ALA 407 154.005 43, ,711 47, ,549 1.00 33, .48 E
ATOM 784δ 0 ALA 407 154.546 44, ,722 47, ,109 1.00 33, .48 E
ATOM 7849 N GLU 408 154.64g 42. .553 47, ,691 1.00 33, .48 E
ATOM 7850 CA GLU 408 156.057 42. .421 47. ,318 1.00 33, .48 E
ATOM 7851 CB GLU 408 156.474 40. ,g48 47. ,284 1.00 33, .48 E
ATOM 7852 CG GLU 408 157.4gg 40. ,53g 48. ,337 1.00 33, .48 E
ATOM 7δ53 CD GLU 408 156. o2 40. ,484 4g. ,742 1.00 33, .48 E
ATOM 7δ54 OEl GLU 408 156.721 41, ,572 50. ,365 1.00 33, .48 E
ATOM 7855 OE2 GLU 408 156.603 39. ,347 50. ,209 1.00 33, .48 E
ATOM 7856 C GLU 408 156.335 43. ,035 45. ,939 1.00 33, .48 E
ATOM 7857 0 GLU 408 157.303 43. ,778 45. ,763 1.00 33, .48 E
ATOM 785δ N VAL 4og 155.508 42. ,710 44. ,g48 1.00 33, .48 E
ATOM 7δ59 CA VAL 409 155.725 43. ,285 43. ,624 1.00 33, .48 E
ATOM 7860 CB VAL 409 154.836 42. ,630 42. ,536 1.00 33, .48 E
ATOM 7861 CGl VAL 409 154.813 41. ,117 42. ,710 1.00 33, .48 E
ATOM 7862 CG2 VAL 409 153.437 43. ,200 42. ,600 1.00 33, ,48 E
ATOM 7863 C VAL 409 155.342 44. ,757 43. ,740 1.00 33, ,4δ E
ATOM 7864 0 VAL 409 156.021 45. ,62g 43. ,lδ8 1.00 33, .4δ E
ATOM 7865 N MET 410 154.262 45. ,020 44. ,475 1.00 33, ,4δ E
ATOM 7866 CA MET 410 153.761 46. ,368 44. ,690 1.00 33, ,4δ E
ATOM 7867 CB MET 410 152.614 46. ,32g 45. ,701 1.00 33, .48 E
ATOM 7868 CG MET 410 151.400 45. ,536 45. ,239 1.00 33, .48 E
ATOM 786g SD MET 410 150.804 46. ,170 43. ,665 1.00 33, ,48 E
ATOM 7870 CE MET 410 149.527 47. ,316 44. ,215 1.00 33, ,48 E ATOM 7871 C MET 410 154,,816 47.373 45.,174 1.0033,.48 E
ATOM 7872 O MET 410 154, ,973 4δ.442 44. ,594 1.00 33, .48 E
ATOM 7873 N MET 411 155, ,539 47.025 46. ,234 1.00 33, .48 E
ATOM 7δ74 CA MET 411 156, ,546 47.914 46. .809 1.00 33 .48 E
ATOM 7875 CB MET 411 157, ,320 47.1δδ 47. ,901 1.00 33, .48 E
ATOM 7876 CG MET 411 156, ,457 46.720 49. ,056 1.00 33, .48 E
ATOM 7877 SD MET 411 157, ,422 45.734 50. ,236 1.00 33, .48 E
ATOM 7878 CE MET 411 158. ,751 45.056 49. ,151 1.00 33, .48 E
ATOM 7879 C MET 411 157. ,544 4δ.563 45. ,853 1.00 33, .48 E
ATOM 78δ0 O MET 411 157. .852 49.747 45. ,999 1.00 33, .48 E
ATOM 7δ81 N LYS 412 158, .057 47.δl4 44. .878 1.00 33, .48 E
ATOM 7882 CA LYS 412 159, ,039 48.393 43. .957 1.00 33, .48 E
ATOM 78δ3 CB LYS 412 160, ,083 47.347 43. .537 1.00 33, .48 E
ATOM 7884 CG LYS 412 161, .027 46.939 44. .647 1.00 33, .48 E
ATOM 7885 CD LYS 412 160, .359 45.960 45. ,577 1.00 33, .48 E
ATOM 78δ6 CE LYS 412 160, .050 44.669 44. ,835 1.00 33, .48 E
ATOM 7887 NZ LYS 412 161, .294 43.911 44. ,49 1.00 33, .48 E
ATOM 7δ88 C LYS 412 158, .49δ 49.087 42. .704 1.00 33, .48 E
ATOM 788g 0 LYS 412 159, .175 4g.gsι 42. .135 1.00 33, .48 E
ATOM 7δgo N LEU 413 157, .306 48.725 42. .250 1.00 33, .48 E
ATOM 7δgι CA LEU 413 156, .781 4g.3g2 41. .067 1.00 33, .48 E
ATOM 7892 CB LEU 413 155, ,7gg 48.476 40. ,343 1.00 33, .48 E
ATOM 7893 CG LEU 413 156, .460 47.128 40. ,027 1.00 33, .48 E
ATOM 7894 CDl LEU 413 155, .433 46.130 39. ,4g2 1.00 33, .48 E
ATOM 7895 CD2 LEU 413 157, ,58g 47.350 39. .021 1.00 33 .48 E
ATOM 7896 C LEU 413 156, ,og4 50.668 41. .536 1.00 33, .48 E
ATOM 7δ97 0 LEU 413 155, .814 50.818 42. .726 1.00 33, .48 E
ATOM 7δg8 N SER 414 155, .847 51.5g4 40. ,617 1.00 33, .48 E
ATOM 7δgg CA SER 414 155, .187 52.85δ 40. ,g50 1.00 33, .48 E
ATOM 7goo CB SER 414 155, .962 53.61δ 42. ,031 1.00 33, .48 E
ATOM 7goι OG SER 414 155, .208 54.715 42. ,527 1.00 33, .48 E
ATOM 7g02 C SER 414 155, .138 53.6gδ 39. ,6g2 1.00 33, .48 E
ATOM 7903 0 SER 414 156, .175 54.112 39. ,179 1.00 33, .48 E
ATOM 7904 N HIS 415 153, .929 53.g43 39. ,206 1.00 33, .48 E
ATOM 7905 CA HIS 415 153, .726 54.718 38. ,000 1.00 33, .48 E
ATOM 7906 CB HIS 415 153, .963 53.835 36. ,773 1.00 33, .48 E
ATOM 7907 CG HIS 415 153, .598 54.480 35. ,472 1.00 33, .48 E
ATOM 790δ CD2 HIS 415 154, .349 54.801 34. ,395 1.00 33, .48 E
ATOM 7909 NDl HIS 415 152, .310 54.868 35. ,16g 1.00 33, .48 E
ATOM 7910 CEl HIS 415 152, .283 55.400 33. ,961 1.00 33, .48 E
ATOM 7911 NE2 HIS 415 153, .508 55.372 33. ,470 1.00 33, .48 E
ATOM 7912 C HIS 415 152, .310 55.216 38. ,013 1.00 33, .48 E
ATOM 7913 0 HIS 415 151, .437 54.612 38. ,611 1.00 33, .48 E
ATOM 7914 N PRO 416 152. ,057 56.342 37. ,356 1.00 33, .48 E ATOM 7915 CD PRO 416 152.gsg 57.236 36,.640 1.00 33..48 E
ATOM 7916 CA PRO 416 150.62 56.867 37, .341 1.00 33, .48 E
ATOM 7917 CB PRO 416 150.746 57.932 36, .260 1.00 33, .48 E
ATOM 7918 CG PRO 416 152.142 58.463 36, ,386 1.00 33, .48 E
ATOM 79ig c PRO 416 14g.623 55.823 37, .058 1.00 33, .48 E
ATOM 7g20 0 PRO 416 148.667 55.709 37, .810 1.00 33, .48 E
ATOM 7g21 N LYS 417 149.792 55.046 35, ,gg4 1.00 33, .48 E
ATOM 7g22 CA LYS 417 148.782 54.059 35, .628 1.00 33, .48 E
ATOM 7g23 CB LYS 417 148.767 53.δ84 34, .115 1.00 33, .48 E
ATOM 7g24 CG LYS 417 148.431 55.183 33, .417 1.00 33, .48 E
ATOM 7g25 CD LYS 417 147.227 55.855 34, .077 1.00 33, .48 E
ATOM 7g26 CE LYS 417 146.941 57.231 33, .478 1.00 33, .48 E
ATOM 7927 NZ LYS 417 146.658 57.200 32, .015 1.00 33, .48 E
ATOM 7928 C LYS 417 148.760 52.694 36. .317 1.00 33, .48 E
ATOM 7929 0 LYS 417 148.262 51.722 35, .763 1.00 33, .48 E
ATOM 7930 N LEU 418 149.2g2 52.627 37, .527 1.00 33, .48 E
ATOM 7931 CA LEU 418 149.255 51.407 38, .306 1.00 33, .48 E
ATOM 7932 CB LEU 418 150.639 50.962 38, .741 1.00 33, .48 E
ATOM 7933 CG LEU 41δ 151.637 50.69δ 37, .641 1.00 33, .48 E
ATOM 7934 CDl LEU 41δ 152.508 4g.547 38, .071 1.00 33, .48 E
ATOM 7935 CD2 LEU 418 150.921 50.375 36, .357 1.00 33, .48 E
ATOM 7936 C LEU 418 148.501 51.836 39. .535 1.00 33, .48 E
ATOM 7937 0 LEU 418 148.412 53.023 39. .810 1.00 33, .48 E
ATOM 793δ N VAL 419 147.945 50.8δg 4O. .272 1.00 33, .48 E
ATOM 7g3 CA VAL 419 147.253 51.233 41. ,4 6 1.00 33, .48 E
ATOM 7940 CB VAL 419 146.145 50.ig5 41. .819 1.00 33, .48 E
ATOM 7941 CGl VAL 419 146.101 4g.δ6δ 43. .315 1.00 33, .48 E
ATOM 7g42 CG2 VAL 419 144.7 δ 50.755 41, .365 1.00 33, .48 E
ATOM 7g43 C VAL 419 148.361 51.256 42, .540 1.00 33, .48 E
ATOM 7944 0 VAL 419 149.231 50.3gθ 42, .548 1.00 33, .48 E
ATOM 7945 N GLN 420 148.345 52.267 43, .397 1.00 33, .48 E
ATOM 7946 CA GLN 420 14g.374 52.416 44, .406 1.00 33 .48 E
ATOM 7947 CB GLN 420 14g.562 53.893 44, .730 1.00 33 .48 E
ATOM 794δ CG GLN 420 151.002 54.292 45, .001 1.00 33, .48 E
ATOM 7g4g CD GLN 420 151.782 54.581 43, .717 1.00 33, .48 E
ATOM 7g50 OEl GLN 420 152.162 53.663 42, .977 1.00 33, .48 E
ATOM 7gsι NE2 GLN 420 152.006 55.870 43, .439 1.00 33, .48 E
ATOM 7g52 C GLN 420 149.133 51.672 45, .717 1.00 33, .48 E
ATOM 7g53 0 GLN 420 148.034 51.667 46, .269 1.00 33, .48 E
ATOM 7g54 N LEU 421 150.174 51.036 46, .223 1.00 33, .48 E
ATOM 7g55 CA LEU 421 150.060 50.370 47, .492 1.00 33, .48 E
ATOM 7 56 CB LEU 421 151.008 49.190 47, .550 1.00 33, .48 E
ATOM 7g57 CG LEU 421 151.508 48.937 48, .968 1.00 33, .48 E
ATOM 7 5δ CDl LEU 421 150.379 4δ.405 49. .816 1.00 33, .48 E ATOM 7g5 CD2 LEU 421 152.655 47.,95g 48,,927 1.00 33.,4δ E
ATOM 7g60 c LEU 421 150. 512 51. ,416 48. ,502 1.00 33. ,48 E
ATOM 7961 0 LEU 421 151. 621 51. ,g37 48. ,387 1.00 33. ,48 E
ATOM 7962 N TYR 422 149. 662 51. ,74g 49. ,470 1.00 33. ,48 E
ATOM 7963 CA TYR 422 150. 033 52. ,724 50. ,492 1.00 33. ,48 E
ATOM 7964 CB TYR 422 148. ,79g 53, .384 51, .099 1.00 33, .48 E
ATOM 7965 CG TYR 422 148. ,078 54, ,33g 50, .187 1.00 33, .48 E
ATOM 7966 CDl TYR 422 146. ,723 54, .574 50, .344 1.00 33, .48 E
ATOM 7967 CEl TYR 422 146. ,056 55, .454 49. ,530 1.00 33, ,48 E
ATOM 7968 CD2 TYR 422 148. ,750 55, .016 49. ,184 1.00 33, .48 E
ATOM 796g CE2 TYR 422 148. ,091 55, ,go3 48. ,365 1.00 33, ,4δ E
ATOM 7 70 CZ TYR 422 146. ,742 56. ,llδ 48. ,544 1.00 33. ,4δ E
ATOM 7g71 OH TYR 422 146. ,076 57. .014 47. ,750 1.00 33, ,4δ E
ATOM 7g72 C TYR 422 150. ,780 51. ,gg2 51. ,58δ 1.00 33. ,48 E
ATOM 7g73 O TYR 422 151. ,g63 52, .224 51. ,δ04 1.00 33. .48 E
ATOM 7974 N GLY 423 150. .074 51, .095 52, ,271 1.00 33, .4δ E
ATOM 7975 CA GLY 423 150. .674 50, .326 53. ,34δ 1.00 33, .48 E
ATOM 7976 C GLY 423 150, ,og7 48, .923 53. .514 1.00 33, .48 E
ATOM 7977 O GLY 423 149. ,041 48, .562 52. ,964 1.00 33, ,4δ E
ATOM 7978 N VAL 424 150. ,807 4δ, .129 54. ,303 1.00 33, .48 E
ATOM 7979 CA VAL 424 150. .450 46, .747 54, .579 1.00 33, .48 E
ATOM 79δ0 CB VAL 424 151, .673 45, .δ43 54, .400 1.00 33, .48 E
ATOM 7g81 CGl VAL 424 152, .332 46, ,09δ 53, .060 1.00 33, .48 E
ATOM 7g82 CG2 VAL 424 152, ,65g 46, .124 55, .506 1.00 33, .48 E
ATOM 7g 3 C VAL 424 150, .027 46, .620 56, .035 1.00 33, .48 E
ATOM 7g 4 O VAL 424 150, .36g 47, .461 56, ,δ69 1.00 33, .48 E
ATOM 7gδ5 N CYS 425 149, .281 45, ,56g 56, ,33g 1.00 33, .48 E
ATOM 7gδ6 CA CYS 425 148, ,δ71 45, ,2gg 57, .712 1.00 33, .48 E
ATOM 7gδ7 CB CYS 425 147, .400 45, .642 57. , 33 1.00 33, .48 E
ATOM 7gδδ SG CYS 425 147, .134 47, .345 58. .548 1.00 33, .48 E
ATOM 7989 C CYS 425 149. .120 43, ,δll 57. ,872 1.00 33, ,48 E
ATOM 7990 O CYS 425 148. ,2gg 42, ,gδg 57. ,46g 1.00 33, .48 E
ATOM 7991 N LEU 426 150. .2δ3 43, .474 5δ, .423 1.00 33, .4δ E
ATOM 7gg2 CA LEU 426 150. .683 42, ,0δ7 58. ,600 1.00 33, .48 E
ATOM 7g 3 CB LEU 426 151, .745 41, .741 57. ,559 1.00 33, .48 E
ATOM 7gg4 CG LEU 426 151, .753 42, .674 56. ,339 1.00 33, .48 E
ATOM 7gg5 CDl LEU 426 152, .992 42, .411 55. ,480 1.00 33, .48 E
ATOM 7g96 CD2 LEU 426 150, .474 42, .4g2 55. .529 1.00 33 .4δ E
ATOM 79g7 C LEU 426 151, .243 41, .δ55 60. ,004 1.00 33, .4δ E
ATOM 7g98 O LEU 426 150, ,497 41, ,62δ 60. ,964 1.00 33 .4δ E
ATOM 79gg N ILE 431 144, .716 40, .137 58. ,404 1.00 33, .4δ E
ATOM δooo CA ILE 431 145, .714 41, .053 57. ,86δ 1.00 33 .4δ E
ATOM δOOl CB ILE 431 147, .050 40, ,2gg 57, ,611 1.00 33 .4δ E
ATOM 8002 CG2 ILE 431 147, .644 39, ,δ57 58. ,931 1.00 33, .4δ E ATOM 8003 CGl ILE 431 146.,δig 39.,076 56.721 1.00 33,.48 E
ATOM 8004 CDl ILE 431 146, ,733 39. ,382 55.229 1.00 33, .48 E
ATOM 8005 C ILE 431 145. ,178 41. ,697 56.587 1.00 33, .48 E
ATOM 8006 O ILE 431 144. ,082 41. ,346 56.139 1.00 33, .48 E
ATOM δ007 N CYS 432 145. ,g26 42. ,627 55.995 1.00 33, .48 E
ATOM δOOδ CA CYS 432 145, ,428 43. ,272 54.787 1.00 33, .48 E
ATOM soog CB CYS 432 144. ,191 44. ,058 55.137 1.00 33, .48 E
ATOM 8010 SG CYS 432 144. ,575 45. ,105 56.516 1.00 33, .48 E
ATOM 8011 C CYS 432 146, ,391 44, ,210 54.074 1.00 33, .48 E
ATOM δ012 O CYS 432 147, ,531 44, ,401 54.497 1.00 33, .48 E
ATOM 8013 N LEU 433 145, .892 44, ,810 52.9g5 1.00 33, .48 E
ATOM 8014 CA LEU 433 146, .663 45, ,731 52.181 1.00 33, .48 E
ATOM δ015 CB LEU 433 147, ,060 45, ,040 50.δ84 1.00 33, .48 E
ATOM δ016 CG LEU 433 147, .818 43, ,730 51.142 1.00 33, .48 E
ATOM δ017 CDl LEU 433 148. .143 43, .040 4g.826 1.00 33, .48 E
ATOM δOlδ CD2 LEU 433 149. .078 44, .017 51.923 1.00 33, .48 E
ATOM δoig C LEU 433 145, .861 47, .000 51.883 1.00 33, .48 E
ATOM δ020 O LEU 433 144, .671 46, ,943 51.562 1.00 33, .48 E
ATOM δ021 N VAL 434 146, .518 48, .152 51.993 1.00 33, .48 E
ATOM 8022 CA VAL 434 145, .857 49, .426 51.739 1.00 33, .48 E
ATOM 8023 CB VAL 434 146, .202 50, .422 52.862 1.00 33, .48 E
ATOM 8024 CGl VAL 434 145, ,382 51, .730 52.718 1.00 33, .48 E
ATOM 8025 CG2 VAL 434 145, .938 49, .752 54.208 1.00 33, .48 E
ATOM 8026 C VAL 434 146, .272 49, ,9g7 50.384 1.00 33, .48 E
ATOM 8027 O VAL 434 147, .441 50, .307 50.178 1.00 33, .48 E
ATOM 802δ N PHE 435 145, .310 50, .126 49.472 1.00 33, .48 E
ATOM 02g CA PHE 435 145, .564 50, .645 4δ.l30 1.00 33, .48 E
ATOM δ030 CB PHE 435 145, .113 49, ,62g 47.089 1.00 33, .48 E
ATOM δ031 CG PHE 435 145, ,7δg 48, .302 47.203 1.00 33 .48 E
ATOM δ032 CDl PHE 435 147, .122 48, ,158 46.872 1.00 33, ,48 E
ATOM δ033 CD2 PHE 435 145, .ogo 47, .191 47.638 1.00 33, .48 E
ATOM δ034 CEl PHE 435 147, .741 46, ,g26 46.973 1.00 33, .48 E
ATOM 8035 CE2 PHE 435 145, .710 45, ,g66 47.741 1.00 33 .48 E
ATOM 8036 CZ PHE 435 147, .030 45, .834 47.409 1.00 33 .48 E
ATOM δ037 C PHE 435 144, ,7g6 51, .940 47.879 1.00 33, .48 E
ATOM 8038 O PHE 435 143, ,δ04 52, ,207 48.550 1.00 33, .48 E
ATOM 803g N GLU 436 145, .234 52, .742 46.912 1.00 33, .48 E
ATOM δ040 CA GLU 436 144, .503 53, .965 46.629 1.00 33 .48 E
ATOM δ041 CB GLU 436 145, .172 54, .756 45.500 1.00 33, .48 E
ATOM δ042 CG GLU 436 145, .321 54, ,022 44.179 1.00 33, .48 E
ATOM δ043 CD GLU 436 145, ,4g2 54, .970 42.991 1.00 33, .48 E
ATOM 8044 OEl GLU 436 144, .6og 55, .821 42.769 1.00 33, .48 E
ATOM 8045 OE2 GLU 436 146, .500 54, .863 42.271 1.00 33, .48 E
ATOM δ046 C GLU 436 143, .og3 53. ,527 46.224 1.00 33, .48 E ATOM 8047 0 GLU 436 142.932 52.536 45.532 1.00 33. ,48 E
ATOM δ048 N PHE 437 142. 069 54. ,252 46.647 1.00 33. ,48 E
ATOM 804g CA PHE 437 140. 717 53. ,845 46.310 1.00 33. .48 E
ATOM 8050 CB PHE 437 139. ,715 54. ,413 47.305 1.00 33. .48 E
ATOM 8051 CG PHE 437 138. ,29g 54. ,147 46.917 1.00 33, .48 E
ATOM δ052 CDl PHE 437 137. 516 55. ,147 46.374 1.00 33. .48 E
ATOM 8053 CD2 PHE 437 137. 775 52. ,871 47.016 1.00 33. .48 E
ATOM 8054 CEl PHE 437 136. ,245 54. ,882 45.933 1.00 33. .48 E
ATOM 8055 CE2 PHE 437 136. ,500 52. ,601 46.574 1.00 33. .48 E
ATOM 8056 CZ PHE 437 135. ,736 53. ,605 46.032 1.00 33. .48 E
ATOM 8057 C PHE 437 140. ,ιg2 54. ,132 44.912 1.00 33, .48 E
ATOM 8058 0 PHE 437 139. ,78g 55. ,242 44.617 1.00 33, .48 E
ATOM δosg N MET 438 140. ,157 53. ,111 44.066 1.00 33, .48 E
ATOM 8060 CA MET 438 139. ,652 53. ,261 42.710 1.00 33, .48 E
ATOM 8061 CB MET 438 140. ,057 52. ,049 41.877 1.00 33, .48 E
ATOM 8062 CG MET 438 141, ,57g 51, ,875 41.786 1.00 33, .48 E
ATOM 8063 SD MET 438 142, .442 53, .393 41.273 1.00 33, .48 E
ATOM 8064 CE MET 43δ 142. ,03g 53. .515 39.511 1.00 33, .48 E
ATOM 8065 C MET 43δ 138. ,134 53. .441 42.733 1.00 33, .48 E
ATOM 8066 0 MET 43δ 137. ,373 52, ,525 43.055 1.00 33, .48 E
ATOM 8067 N GLU 439 137. ,714 54, .649 42.374 1.00 33, .48 E
ATOM 8068 CA GLU 439 136. .315 55, .085 42.380 1.00 33 .48 E
ATOM 806g CB GLU 439 136, .317 56, .603 42.159 1.00 33 .48 E
ATOM 8070 CG GLU 439 134, ,gg7 57, .266 41.891 1.00 33 .48 E
ATOM 8071 CD GLU 439 135, ,186 58. ,722 41.506 1.00 33, .48 E
ATOM 8072 OEl GLU 439 136, .125 59. .022 40.723 1.00 33, .48 E
ATOM 8073 0E2 GLU 439 134, .395 sg. .572 41.980 1.00 33, .48 E
ATOM 8074 C GLU 43g 135, .296 54, .408 41.452 1.00 33 .48 E
ATOM 8075 0 GLU 43g 134. .124 54, ,7go 41.434 1.00 33 .48 E
ATOM 8076 N HIS 440 135, .713 53, .415 40.678 1.00 33 .48 E
ATOM 8077 CA HIS 440 134, .761 52, .736 39.7gθ 1.00 33, .48 E
ATOM 8078 CB HIS 440 134, .738 53, ,3gg 38.417 1.00 33, .48 E
ATOM 807g CG HIS 440 134, .254 54, .812 38.445 1.00 33, .48 E
ATOM 8080 CD2 HIS 440 133, .121 55, .377 37.g62 1.00 33 .48 E
ATOM 8081 NDl HIS 440 134, .g65 55, .82g 3g.044 1.00 33 .48 E
ATOM 8082 CEl HIS 440 134, .290 56, .g6i 38.g26 1.00 33 .48 E
ATOM 8083 NE2 HIS 440 133, .167 56 .715 38.274 1.00 33 .48 E
ATOM 8084 C HIS 440 135, .060 51, .252 3g.636 1.00 33 .48 E
ATOM 8085 0 HIS 440 134, .683 50, .62g 38.642 1.00 33 .48 E
ATOM 8086 N GLY 441 135, .739 50, .692 40.631 1.00 33 .48 E
ATOM 8087 CA GLY 441 136, .078 49, .2δ6 40.5δ6 1.00 33 .48 E
ATOM 8088 C GLY 441 136, .560 48, .δ05 3g.230 1.00 33 .48 E
ATOM 808g 0 GLY 441 137, .314 49, .500 38.551 1.00 33 .48 E
ATOM 8090 N CYS 442 136, .09δ 47, .623 38.827 1.00 33 .48 E ATOM δogi CA CYS 442 136.,513 47.,016 37.,569 1.00 33,.48 E
ATOM og2 CB CYS 442 136. ,184 45. ,537 37. ,596 1.00 33, .48 E
ATOM og3 SG CYS 442 137. ,051 44. ,741 38. ,923 1.00 33, ,48 E
ATOM 8094 C CYS 442 136. ,030 47. ,602 36. ,261 1.00 33, ,48 E
ATOM 8095 0 CYS 442 134. ,872 47. ,978 36. ,115 1.00 33, .48 E
ATOM δ096 N LEU 443 136. ,954 47. ,656 35. ,305 1.00 33, .48 E
ATOM δog7 CA LEU 443 136. ,670 48. ,174 33. ,9δ2 1.00 33, .48 E
ATOM δogδ CB LEU 443 137. ,948 48. ,126 33. ,133 1.00 33, .48 E
ATOM δogg CG LEU 443 137. ,968 48. ,585 31. ,672 1.00 33, .48 E
ATOM δlOO CDl LEU 443 137. ,325 49. ,940 31. ,497 1.00 33, .48 E
ATOM δioi CD2 LEU 443 139. ,405 48. ,616 31. ,207 1.00 33, .48 E
ATOM δl02 C LEU 443 135. ,551 47. ,320 33. ,3δ7 1.00 33, .48 E
ATOM δl03 0 LEU 443 134. ,587 47. ,840 32, ,δ27 1.00 33, .48 E
ATOM δl04 N SER 444 135. .675 46. .005 33, ,542 1.00 33, .48 E
ATOM δl05 CA SER 444 134. .669 45. .072 33, .042 1.00 33, .48 E
ATOM 8106 CB SER 444 135, .050 43. ,643 33. .421 1.00 33, .48 E
ATOM 8107 OG SER 444 135, .286 43. .529 34. ,δ07 1.00 33, .48 E
ATOM 8108 C SER 444 133. .272 45. .412 33. .573 1.00 33, .48 E
ATOM 8iog 0 SER 444 132. .332 45. .567 32. ,794 1.00 33, .48 E
ATOM 8110 N ASP 445 133. .138 45. .535 34. ,δ90 1.00 33, .48 E
ATOM 8111 CA ASP 445 131. .850 45, .877 35, ,4 9 1.00 33, .48 E
ATOM 8112 CB ASP 445 131, .974 45, .902 37, ,01δ 1.00 33, .48 E
ATOM 8113 CG ASP 445 132, .451 44, .586 37, .585 1.00 33, .48 E
ATOM 8114 ODl ASP 445 131, .648 43, .620 37, .595 1.00 33, .48 E
ATOM 8115 OD2 ASP 445 133, .628 44, .508 38, .015 1.00 33, .48 E
ATOM 8116 C ASP 445 131, .402 47, .259 35, .030 1.00 33, .48 E
ATOM 8117 0 ASP 445 130, .221 47, ,50δ 34, .784 1.00 33, .48 E
ATOM 8118 N TYR 446 132, .381 48. ,150 34, .918 1.00 33, .48 E
ATOM 8119 CA TYR 446 132, .182 49. .530 34, .509 1.00 33, .48 E
ATOM 8120 CB TYR 446 133, .496 50, .278 34, .644 1.00 33, .48 E
ATOM 8121 CG TYR 446 133, ,3g 51, .736 34, .324 1.00 33, .48 E
ATOM 8122 CDl TYR 446 132, ,g67 52, .643 35, .281 1.00 33, .48 E
ATOM 8123 CEl TYR 446 132, ,884 53, .983 35, .000 1.00 33, .48 E
ATOM 8124 CD2 TYR 446 133, .740 52, .211 33, .061 1.00 33, .48 E
ATOM δl25 CE2 TYR 446 133, .660 53, .550 32, .762 1.00 33, .48 E
ATOM δl26 CZ TYR 446 133, .233 54, .432 33, .741 1.00 33, .48 E
ATOM δl27 OH TYR 446 133, ,16g 55, .776 33, .463 1.00 33, .48 E
ATOM δl2δ C TYR 446 131, ,711 49, .608 33, .080 1.00 33, .48 E
ATOM δl29 0 TYR 446 130, ,7gδ 50, .353 32, .755 1.00 33, .48 E
ATOM δl30 N LEU 447 132, .362 48, .835 32, .224 1.00 33, .48 E
ATOM δl31 CA LEU 447 132, .029 48, .793 30, ,δ05 1.00 33, .48 E
ATOM δl32 CB LEU 447 132, .971 47, ,825 30, .097 1.00 33, .48 E
ATOM δl33 CG LEU 447 134, .363 48. ,413 29, .970 1.00 33, .48 E
ATOM δl34 CDl LEU 447 135, .398 47. ,333 29, ,723 1.00 33, .48 E ATOM 8135 CD2 LEU 447 134,.319 49,.429 28,.851 1.0033.48 E
ATOM 8136 C LEU 447 130, .581 48, .369 30, .570 1.00 33 .48 E
ATOM 8137 0 LEU 447 129, .813 49, .057 29. .88δ 1.00 33 .48 E
ATOM 813δ N ARG 44δ 130, ,220 47, .229 31. .147 1.00 33 .48 E
ATOM δl3 CA ARG 44δ 128, ,δδ5 46, .700 30, .ggg 1.00 33 .48 E
ATOM 8140 CB ARG 448 128, ,δ25 45, .336 31, ,6go 1.00 33 .48 E
ATOM 8141 CG ARG 448 129, .774 44, .320 31. .035 1.00 33 .48 E
ATOM δl42 CD ARG 448 130, .118 43, .113 31. ,g28 1.00 33 .48 E
ATOM δl43 NE ARG 448 131, .266 42, .369 31. ,3g4 1.00 33 .48 E
ATOM δl44 CZ ARG 448 132, .150 41, ,695 32. .130 1.00 33, .48 E
ATOM δl45 NHl ARG 448 132, .041 41, .644 33. ,454 1.00 33, .48 E
ATOM δl46 NH2 ARG 44δ 133, .174 41, .094 31. .541 1.00 33 .48 E
ATOM δl47 C ARG 448 127, .858 47, .690 31, ,55g 1.00 33 .48 E
ATOM 8148 0 ARG 448 126, .83δ 47, ,9go 30, ,g26 1.00 33 .48 E
ATOM 814g N THR 44g 128, .150 48, .232 32, .730 1.00 33 .48 E
ATOM 8150 CA THR 44g 127, .255 49, .184 33, .350 1.00 33 .48 E
ATOM 8151 CB THR 44g 127, .δ3δ 49, .655 34, ,6g4 1.00 33 .48 E
ATOM 8152 OGl THR 44g 127, .790 48, .572 35, .628 1.00 33 .48 E
ATOM δl53 CG2 THR 44g 127, .049 50, .811 35, .256 1.00 33 .48 E
ATOM δl54 C THR 449 126, ,94δ 50, ,3g2 32, ,45g 1.00 33 .48 E
ATOM δl55 0 THR 449 125, ,δ20 50, .876 32, ,445 1.00 33, .48 E
ATOM 8156 N GLN 450 127, , 2g 50. .861 31, .691 1.00 33, .48 E
ATOM 8157 CA GLN 450 127, .72g 52, .03g 30, .837 1.00 33 .48 E
ATOM 8158 CB GLN 450 128, .g25 52, ,g7g 30, .g74 1.00 33 .48 E
ATOM 815g CG GLN 450 129, .460 53, .168 32, .378 1.00 33 .48 E
ATOM δl60 CD GLN 450 128, .454 53, .811 33, ,28g 1.00 33 .48 E
ATOM 8161 OEl GLN 450 127, .644 54, .627 32, ,853 1.00 33, .48 E
ATOM 8162 NE2 GLN 450 128. .503 53, .460 34. ,566 1.00 33, .48 E
ATOM 8163 C GLN 450 127. ,5og 51. ,7g5 2g. ,336 1.00 33, .48 E
ATOM 8164 0 GLN 450 127. .464 52. ,746 28. ,563 1.00 33, ,48 E
ATOM 8165 N ARG 451 127. ,3δ0 50. ,538 28. ,g20 1.00 33, .48 E
ATOM δl66 CA ARG 451 127. .194 50. .198 27. ,503 1.00 33, .48 E
ATOM δl67 CB ARG 451 126, .733 48, .747 27. ,3go 1.00 33, .48 E
ATOM δl6δ CG ARG 451 126, .634 48, .260 25. ,g6i 1.00 33, .48 E
ATOM δiεg CD ARG 451 126, .249 46, ,78g 25. ,goo 1.00 33, .48 E
ATOM 8170 NE ARG 451 127, .293 45, ,g30 26. ,446 1.00 33, .48 E
ATOM 8171 CZ ARG 451 127, ,253 44, ,600 26. ,417 1.00 33, .48 E
ATOM 8172 NHl ARG 451 126, ,208 43. ,gδ8 25. ,861 1.00 33, .48 E
ATOM 8173 NH2 ARG 451 128, ,251 43. ,880 26. ,g37 1.00 33, .48 E
ATOM δl74 C ARG 451 126. ,235 51. ,105 26. ,717 1.00 33, .48 E
ATOM δl75 0 ARG 451 125. ,089 51. ,306 27. ,107 1.00 33, .48 E
ATOM 8176 N GLY 452 126. ,705 51. ,648 25. ,5g8 1.00 33, .48 E
ATOM 8177 CA GLY 452 125. ,862 52. ,525 24. ,7g8 1.00 33, .48 E
ATOM 817δ C GLY 452 126. ,141 54. ,005 25. ,013 1.00 33, .48 E ATOM 817g O GLY 452 125..745 54,.857 24,.215 1.0033.48 E
ATOM 81δ0 N LEU 453 126. ,δ2δ 54, .320 26, .098 1.00 33, .48 E
ATOM δlδl CA LEU 453 127. .149 55, ,69δ 26, ,409 1.00 33, .48 E
ATOM δiδ2 CB LEU 453 127. ,119 55, ,δδ4 27, ,921 1.00 33, .48 E
ATOM δlδ3 CG LEU 453 125. ,7δg 55, ,46g 28. ,567 1.00 33, .48 E
ATOM δl84 CDl LEU 453 125. ,g76 55, .138 30. ,048 1.00 33, .48 E
ATOM 8185 CD2 LEU 453 124. , 788 56, ,5 2 28. ,375 1.00 33, .48 E
ATOM 8186 C LEU 453 128. ,533 56, .015 25. ,864 1.00 33, .48 E
ATOM 8187 O LEU 453 128. ,766 57, .076 25. ,281 1.00 33, .48 E
ATOM 818δ N PHE 454 129. ,452 55, .078 26. ,051 1.00 33, .48 E
ATOM 818g CA PHE 454 130. ,δ20 55, ,242 25. ,591 1.00 33, .48 E
ATOM δigo CB PHE 454 131, ,54g 53, ,go6 25. .698 1.00 33 .48 E
ATOM 8191 CG PHE 454 131, ,7g9 53, .485 27. .103 1.00 33 .48 E
ATOM 8192 CDl PHE 454 132, .764 54, .127 27. .867 1.00 33 .48 E
ATOM 8193 CD2 PHE 454 131, .054 52, .472 27. .678 1.00 33 .48 E
ATOM 8194 CEl PHE 454 132, ,9go 53, .769 29, .185 1.00 33, .48 E
ATOM 8195 CE2 PHE 454 131, .270 52, .105 29. .003 1.00 33, .48 E
ATOM 8196 CZ PHE 454 132, .244 52, .758 29. .760 1.00 33, .48 E
ATOM δl97 C PHE 454 130, .914 55, . 777 24. .170 1.00 33, .48 E
ATOM 8ig8 O PHE 454 130. ,09g 55, .451 23. ,318 1.00 33, .48 E
ATOM δl99 N ALA 455 131. ,gi7 56, .609 23. ,931 1.00 33, .48 E
ATOM δ200 CA ALA 455 132. .140 57, .184 22. ,617 1.00 33, .48 E
ATOM 8201 CB ALA 455 132, .187 58. .684 22. ,708 1.00 33, .48 E
ATOM 8202 C ALA 455 133, .467 56, .657 22. ,130 1.00 33, .48 E
ATOM 8203 O ALA 455 134, .484 56, .857 22. .782 1.00 33, .48 E
ATOM 8204 N ALA 456 133, .440 55, .983 20. ,984 1.00 33, .48 E
ATOM 8205 CA ALA 456 134, .619 55, .374 20. ,369 1.00 33, .48 E
ATOM 8206 CB ALA 456 134, .572 55, .595 18. ,8δ7 1.00 33, .48 E
ATOM δ207 C ALA 456 135, .950 55, .863 20. ,915 1.00 33, .48 E
ATOM δ20δ O ALA 456 136. .836 55, ,079 21. ,244 1.00 33, .48 E
ATOM δ20g N GLU 457 136. .072 57, ,175 21. ,011 1.00 33, .48 E
ATOM δ210 CA GLU 457 137. ,276 57, ,815 21. ,4δ5 1.00 33, .48 E
ATOM 8211 CB GLU 457 137. ,191 59, .308 21, ,188 1.00 33, .48 E
ATOM δ212 CG GLU 457 136. ,667 59, .600 19, ,770 1.00 33, .48 E
ATOM δ213 CD GLU 457 135. ,131 59, .495 19. ,641 1.00 33, .48 E
ATOM δ214 OEl GLU 457 134. ,543 58, ,446 20. ,016 1.00 33, .48 E
ATOM δ215 OE2 GLU 457 134. ,506 60. ,473 19. ,150 1.00 33, .48 E
ATOM 8216 C GLU 457 137. ,538 57. ,567 22. ,g57 1.00 33, .48 E
ATOM 8217 O GLU 457 138. ,6δ4 57. ,474 23. ,364 1.00 33, .48 E
ATOM 8218 N THR 45δ 136. ,49δ 57. ,45δ 23. ,767 1.00 33, .48 E
ATOM 82ig CA THR 458 136. ,723 57. ,193 25. ,181 1.00 33, .48 E
ATOM δ220 CB THR 458 135. ,442 57. ,194 25. ggs 1.00 33, ,48 E
ATOM δ221 OGl THR 458 134. ,627 58. ,309 25. ,635 1.00 33, ,48 E
ATOM δ222 CG2 THR 458 135. ,7δ6 57. ,294 27. ,470 1.00 33, .48 E ATOM 8223 C THR 458 137..304 55..793 25.,286 1.0033,.48 E
ATOM 8224 0 THR 458 138. ,116 55. .497 26. ,168 1.00 33, .48 E
ATOM 8225 N LEU 45g 136. ,856 54. ,930 24. ,3δ0 1.00 33, .48 E
ATOM δ226 CA LEU 45g 137. .323 53. ,559 24. .319 1.00 33 .48 E
ATOM δ227 CB LEU 45g 136. .627 52, ,δOδ 23, .178 1.00 33 .48 E
ATOM δ228 CG LEU 45g 135, .158 52, .429 23, .344 1.00 33 .48 E
ATOM 822g CDl LEU 45g 134, ,9go 51, .670 24, .638 1.00 33 .48 E
ATOM δ230 CD2 LEU 45g 134, ,2g8 53, .659 23, .362 1.00 33 .48 E
ATOM δ231 C LEU 45g 138, .818 53, .589 24, .068 1.00 33 .48 E
ATOM δ232 0 LEU 45g 139. .602 53, .089 24, ,865 1.00 33, .48 E
ATOM δ233 N LEU 460 139. .201 54, .188 22. ,94g 1.00 33, .48 E
ATOM δ234 CA LEU 460 140, .601 54, .294 22. ,5go 1.00 33, .48 E
ATOM 8235 CB LEU 460 140, .779 55, .170 21. ,354 1.00 33, .48 E
ATOM 8236 CG LEU 460 142, .234 55, .465 20. ,g73 1.00 33, .48 E
ATOM 8237 CDl LEU 460 142, .891 54, .204 20. ,444 1.00 33, .48 E
ATOM 823δ CD2 LEU 460 142, .283 56, .571 19. .931 1.00 33 .48 E
ATOM δ23g C LEU 460 141, .370 54, ,89g 23. .745 1.00 33, .48 E
ATOM δ240 0 LEU 460 142, ,54g 54, .619 23. .922 1.00 33 .48 E
ATOM δ241 N GLY 461 140, .702 55, .734 24, .530 1.00 33, .48 E
ATOM δ242 CA GLY 461 141, .363 56, .34g 25, .661 1.00 33 .48 E
ATOM 8243 C GLY 461 141, .786 55, .313 26, .684 1.00 33 .48 E
ATOM 8244 0 GLY 461 142, . 56 55, .260 27, .074 1.00 33 .48 E
ATOM 8245 N MET 462 140, .82g 54, ,482 27, .111 1.00 33 .48 E
ATOM 8246 CA MET 462 141, .073 53, .437 28, .106 1.00 33 .48 E
ATOM 8247 CB MET 462 139, .782 52, .666 28, .373 1.00 33 .48 E
ATOM 824δ CG MET 462 138, .538 53, .535 28, .359 1.00 33 .48 E
ATOM δ24g SD MET 462 137, .005 52, .74g 28, ,97g 1.00 33, .48 E
ATOM δ250 CE MET 462 137, .014 53, ,3ig 30. .666 1.00 33, .48 E
ATOM δ251 C MET 462 142, .169 52, ,487 27. .630 1.00 33, .48 E
ATOM δ252 0 MET 462 143, .007 52. .030 28. .408 1.00 33, .48 E
ATOM 8253 N CYS 463 142, .173 52. .186 26. .344 1.00 33, .48 E
ATOM 8254 CA CYS 463 143, ,203 51. .312 25. .842 1.00 33, .48 E
ATOM 8255 CB CYS 463 142, .965 51. .oig 24. ,36δ 1.00 33, .48 E
ATOM 8256 SG CYS 463 141, .467 50. .026 24. ,103 1.00 33, .48 E
ATOM δ257 C CYS 463 144, .574 51. ,g48 26. ,05δ 1.00 33, .48 E
ATOM δ258 0 CYS 463 145, .547 51, ,248 26, ,351 1.00 33 .48 E
ATOM 825g N LEU 464 144, .639 53, ,278 25, ,g43 1.00 33 .48 E
ATOM δ260 CA LEU 464 145, .881 54, .027 26, .122 1.00 33 .48 E
ATOM δ261 CB LEU 464 145, .694 55, .472 25, .652 1.00 33 .48 E
ATOM 8262 CG LEU 464 146, .671 55, .973 24. .581 1.00 33 .48 E
ATOM 8263 CDl LEU 464 146, .256 57. .339 24. .091 1.00 33 .48 E
ATOM 8264 CD2 LEU 464 148, ,06δ 56. .021 25. ,144 1.00 33, .48 E
ATOM 8265 C LEU 464 146, .415 54. .014 27. ,560 1.00 33, .48 E
ATOM 8266 0 LEU 464 147. .596 53. ,747 27. , 777 1.00 33, .48 E ATOM 8267 N ASP 465 145.571 54.304 28.547 1.00 33. ,48 E
ATOM 8268 CA ASP 465 146.053 54. 2δ0 29. 922 1.00 33. ,48 E
ATOM 8269 CB ASP 465 144.912 54. 3δ0 30. 944 1.00 33. .48 E
ATOM 8270 CG ASP 465 144.165 55. 69 30. δ79 1.00 33. ,48 E
ATOM 8271 ODl ASP 465 143.236 55. δ δ 31. ,6δ9 1.00 33. ,48 E
ATOM 8272 OD2 ASP 465 144.4 o 56. ,541 30. ,022 1.00 33, .48 E
ATOM 8273 C ASP 465 146.727 52. ,931 30. ,09δ 1.00 33, .48 E
ATOM δ274 0 ASP 465 147. gig 52. ,845 30. ,415 1.00 33, .48 E
ATOM δ275 N VAL 466 145. g56 51. ,871 29. ,866 1.00 33, .48 E
ATOM 8276 CA VAL 466 146.47g 50. ,526 30. ,02g 1.00 33, .48 E
ATOM 8277 CB VAL 466 145.472 49. ,454 29. ,536 1.00 33, .48 E
ATOM δ27δ CGl VAL 466 146.112 48. ,077 29. ,578 1.00 33, .48 E
ATOM 8279 CG2 VAL 466 144.248 49. ,447 30. ,42g 1.00 33, .48 E
ATOM 8280 C VAL 466 147.812 50. ,366 29. ,325 1.00 33, .48 E
ATOM 82δl 0 VAL 466 148.756 49. ,δ59 29. ,917 1.00 33, .48 E
ATOM δ2δ2 N CYS 467 147.911 50. ,δ20 28. ,080 1.00 33, .48 E
ATOM δ2δ3 CA CYS 467 149.168 50. ,6δg 27. ,364 1.00 33, .48 E
ATOM δ2δ4 CB CYS 467 14g.009 51, .108 25. .908 1.00 33, .48 E
ATOM 8285 SG CYS 467 150.422 50, ,5 2 24, .896 1.00 33, .48 E
ATOM 8286 C CYS 467 150.326 51, .466 28, .021 1.00 33, .48 E
ATOM 82δ7 0 CYS 467 151.473 51, .024 27, ,9 3 1.00 33 .48 E
ATOM 828δ N GLU 468 150.044 52, .617 28. .615 1.00 33 .48 E
ATOM 8289 CA GLU 468 151.113 53. .345 29. ,281 1.00 33, .48 E
ATOM 8290 CB GLU 468 150.596 54. .646 29. .872 1.00 33, .48 E
ATOM δ2gι CG GLU 468 150.152 55. ,65δ 28. .862 1.00 33, .48 E
ATOM 2g2 CD GLU 468 149.633 56. ,g23 29, .523 1.00 33 .48 E
ATOM 82g3 OEl GLU 468 150.357 57, .442 30, .403 1.00 33 .48 E
ATOM 82 4 OE2 GLU 468 148.517 57, ,3g5 29, ,166 1.00 33 .48 E
ATOM δ2g5 C GLU 468 151.660 52, ,47δ 30, .424 1.00 33 .48 E
ATOM δ2g6 0 GLU 468 152.845 52, .127 30, .45g 1.00 33 .48 E
ATOM δ2 7 N GLY 46 150.787 52, .137 31, .367 1.00 33 .48 E
ATOM δ2 δ CA GLY 46 151.211 51, .321 32, .485 1.00 33 .48 E
ATOM 2 g C GLY 46 151.916 50, ,07g 32, .001 1.00 33 .48 E
ATOM δ300 0 GLY 46g 152.970 49. .706 32, ,517 1.00 33 .48 E
ATOM δ301 N MET 470 151.343 49, .434 30, .ggs 1.00 33 .48 E
ATOM δ302 CA MET 470 151.951 48, .230 30, .477 1.00 33 .48 E
ATOM δ303 CB MET 470 150.988 47, .503 29, .540 1.00 33 .48 E
ATOM δ304 CG MET 470 149.867 46, .773 30, .302 1.00 33 .48 E
ATOM δ305 SD MET 470 150.315 45, .137 31, .026 1.00 33 .48 E
ATOM δ306 CE MET 470 151.782 45, .458 31, .958 1.00 33 .48 E
ATOM δ307 C MET 470 153.276 48, .512 29, .805 1.00 33 .48 E
ATOM 8308 0 MET 470 154.135 47, .643 29, .761 1.00 33 .48 E
ATOM 830g N ALA 471 153.461 49, .727 29 .295 1.00 33 .48 E
ATOM 8310 CA ALA 471 154.735 50, .077 28, .672 1.00 33 .48 E ATOM 8311 CB ALA 471 154.612 51.384 27. ,940 1.00 33. ,48 E
ATOM 8312 C ALA 471 155.734 50. 204 29. 815 1.00 33. ,48 E
ATOM 8313 O ALA 471 156.890 49. ,794 29. ,714 1.00 33. .48 E
ATOM 8314 N TYR 472 155.261 50. ,775 30. ,915 1.00 33. .48 E
ATOM 8315 CA TYR 472 156.075 50. 954 32. ,104 1.00 33. .48 E
ATOM 8316 CB TYR 472 155.260 51. ,649 33. ,208 1.00 33, .48 E
ATOM 8317 CG TYR 472 155.962 51. ,675 34. ,554 1.00 33, .48 E
ATOM 8318 CDl TYR 472 156.669 52. ,792 34. ,975 1.00 33, .48 E
ATOM 8319 CEl TYR 472 157.368 52. ,781 36. ,176 1.00 33. .48 E
ATOM 8320 CD2 TYR 472 155.969 50. ,548 35. ,375 1.00 33, .48 E
ATOM 8321 CE2 TYR 472 156.660 50. ,528 36. ,568 1.00 33. .48 E
ATOM 8322 CZ TYR 472 157.359 51. ,643 36. ,964 1.00 33. .48 E
ATOM 8323 OH TYR 472 158.061 51. ,606 38. ,149 1.00 33, .48 E
ATOM 8324 C TYR 472 156.565 49. ,605 32. ,615 1.00 33, .48 E
ATOM 8325 O TYR 472 157.737 49. ,439 32. ,919 1.00 33, .48 E
ATOM δ326 N LEU 473 155.654 48. ,645 32. ,722 1.00 33, .48 E
ATOM δ327 CA LEU 473 156.011 47. ,321 33, ,212 1.00 33, .48 E
ATOM δ328 CB LEU 473 154.739 46. ,502 33. ,447 1.00 33, .48 E
ATOM δ329 CG LEU 473 154.014 46. .912 34. .734 1.00 33 .48 E
ATOM δ330 CDl LEU 473 152.619 46. ,371 34, .784 1.00 33 .48 E
ATOM δ331 CD2 LEU 473 154.812 46. ,404 35, ,910 1.00 33, .48 E
ATOM δ332 C LEU 473 156.980 46. .595 32, .284 1.00 33 .48 E
ATOM 8333 O LEU 473 157.845 45. ,δ47 32, .738 1.00 33 .48 E
ATOM 8334 N GLU 474 156.846 46. .835 30, .986 1.00 33, .48 E
ATOM 8335 CA GLU 474 157.726 46. ,223 29. ,9g5 1.00 33, .48 E
ATOM 8336 CB GLU 474 157.235 46. .583 28, ,5g9 1.00 33 .48 E
ATOM 8337 CG GLU 474 158.128 46, ,118 27. ,469 1.00 33, .48 E
ATOM 8338 CD GLU 474 157.417 46. ,196 26. ,121 1.00 33, .48 E
ATOM 8339 OEl GLU 474 156.842 47, ,268 25. ,813 1.00 33 .48 E
ATOM 8340 OE2 GLU 474 157.431 45, .186 25. ,373 1.00 33 .48 E
ATOM 8341 C GLU 474 159.172 46, ,694 30. ,167 1.00 33, .48 E
ATOM 8342 O GLU 474 160.119 45, ,933 29. ,97g 1.00 33 .48 E
ATOM δ343 N GLU 475 159.314 47, .963 30. .535 1.00 33 .48 E
ATOM δ344 CA GLU 475 160.604 48, .617 30. .745 1.00 33 .48 E
ATOM δ345 CB GLU 475 160.378 50, .126 30, .730 1.00 33 .48 E
ATOM 8346 CG GLU 475 161.585 51, .030 30, .546 1.00 33 .48 E
ATOM 8347 CD GLU 475 161.129 52, .474 30. .276 1.00 33 .48 E
ATOM δ34δ OEl GLU 475 160.218 52, .948 31. .002 1.00 33 .48 E
ATOM δ349 OE2 GLU 475 161.661 53, .133 29, .344 1.00 33 .48 E
ATOM 8350 C GLU 475 161.191 48, .178 32, .082 1.00 33 .48 E
ATOM 8351 O GLU 475 162.394 47, ,938 32. ,ιgg 1.00 33 .48 E
ATOM 8352 N ALA 476 160.326 48, .075 33, .086 1.00 33 .48 E
ATOM 8353 CA ALA 476 160.726 47, .642 34, .420 1.00 33 .48 E
ATOM 8354 CB ALA 476 159.639 47, .967 35. .425 1.00 33 .48 E ATOM 8355 C ALA 476 160.966 46.135 34.,388 1.0033.,48 E
ATOM 8356 0 ALA 476 161. 311 45.522 35. ,403 1.00 33. .48 E
ATOM δ357 N CYS 477 160. 767 45.54g 33. ,211 1.00 33. ,48 E
ATOM 8358 CA CYS 477 160. 967 44.124 33. ,017 1.00 33. .48 E
ATOM 8359 CB CYS 477 162. 439 43.778 33. ,176 1.00 33. .48 E
ATOM 8360 SG CYS 477 163. 348 44.132 31. ,676 1.00 33, .48 E
ATOM 8361 C CYS 477 160. .131 43.23g 33. ,gi6 1.00 33, .48 E
ATOM 8362 0 CYS 477 160. ,483 42.08δ 34. ,163 1.00 33, ,4δ E
ATOM 8363 N VAL 47δ 159. ,031 43.7gθ 34. ,409 1.00 33, .4δ E
ATOM δ364 CA VAL 478 158. ,112 43.04δ 35. ,249 1.00 33, .4δ E
ATOM 8365 CB VAL 478 157, ,378 43.g62 36. ,247 1.00 33, .4δ E
ATOM 8366 CGl VAL 478 156. ,074 43.315 36. ,679 1.00 33, ,4δ E
ATOM δ367 CG2 VAL 47δ 158. .257 44.228 37. ,451 1.00 33, .4δ E
ATOM δ36δ C VAL 478 157. .086 42.4g4 34. ,289 1.00 33, ,4δ E
ATOM δ369 0 VAL 478 156, .518 43.245 33. ,507 1.00 33, .48 E
ATOM δ370 N ILE 47g 156. .853 41.188 34. ,333 1.00 33, .48 E
ATOM δ371 CA ILE 47g 155, .874 40.5gθ 33. ,443 1.00 33, ,48 E
ATOM δ372 CB ILE 479 156. ,270 3g.l82 33. ,068 1.00 33, .48 E
ATOM δ373 CG2 ILE 479 155, .196 3δ.56g 32. ,199 1.00 33, ,4δ E
ATOM δ374 CGl ILE 479 157. .621 3g.ιg4 32. ,360 1.00 33, ,4δ E
ATOM 8375 CDl ILE 479 158, .122 37.796 31. ,9g7 1.00 33, .48 E
ATOM 8376 C ILE 479 154. ,49δ 40.535 34. ,084 1.00 33, .48 E
ATOM 8377 0 ILE 479 154. .352 40.129 35. ,231 1.00 33, .48 E
ATOM 8378 N HIS 480 153, .4δ0 40.964 33. ,357 1.00 33 .48 E
ATOM 837g CA HIS 480 152, .139 40.908 33, ,gi3 1.00 33, .4δ E
ATOM δ3δ0 CB HIS 480 151, .334 42.122 33, .488 1.00 33 .4δ E
ATOM δ3δl CG HIS 480 149, .9g2 42.205 34, .134 1.00 33 .4δ E
ATOM δ3δ2 CD2 HIS 480 148, .gio 42.963 33, .843 1.00 33 .48 E
ATOM δ3δ3 NDl HIS 480 149, .681 41.517 35, .284 1.00 33 .48 E
ATOM δ3δ4 CEl HIS 480 148, .467 41.δ56 35, ,680 1.00 33 .48 E
ATOM δ3δ5 NE2 HIS 480 147, .978 42.734 34, .824 1.00 33, .48 E
ATOM δ3δ6 C HIS 480 151, .551 39.646 33, .324 1.00 33 .48 E
ATOM 8387 0 HIS 480 151. .871 39.2g2 32, .182 1.00 33, .4δ E
ATOM 83δ8 N ARG 481 150, .704 3δ.g45 34, .066 1.00 33 .48 E
ATOM 83δg CA ARG 481 150, .162 37.723 33, .515 1.00 33, .48 E
ATOM δ3go CB ARG 481 150, .739 36.52δ 34, .247 1.00 33 .4δ E
ATOM δ3gι CG ARG 481 152, .233 36.472 34. .323 1.00 33, .48 E
ATOM 3g2 CD ARG 481 152, ,536 35.053 34. .707 1.00 33 .48 E
ATOM δ3g3 NE ARG 481 153, ,δ63 34.811 35. ,24g 1.00 33, .48 E
ATOM 83g4 CZ ARG 481 154, .180 33.687 35, .885 1.00 33 .48 E
ATOM 8395 NHl ARG 481 153, .262 32.735 36, .051 1.00 33 .48 E
ATOM 8396 NH2 ARG 481 155, .408 33.506 36, .350 1.00 33 .48 E
ATOM 8397 C ARG 481 148, ,671 37.604 33, .548 1.00 33 .48 E
ATOM 839δ 0 ARG 481 148, .115 36.613 33, .085 1.00 33 .4δ E ATOM δ3g9 N ASP 4δ2 14δ.000 38.,605 34..066 1.0033,.4δ E
ATOM δ400 CA ASP 4δ2 146.573 38. ,527 34. ,180 1.00 33, .4δ E
ATOM δ401 CB ASP 4δ2 146.205 3δ. ,446 35. ,653 1.00 33, .48 E
ATOM δ402 CG ASP 4δ2 145.148 37. ,403 35. ,939 1.00 33, .48 E
ATOM δ403 ODl ASP 4δ2 144. ggg 37. ,0δ4 37. ,140 1.00 33, .48 E
ATOM δ404 OD2 ASP 4δ2 144.46g 36. ,908 34. ,995 1.00 33 .48 E
ATOM 8405 C ASP 482 145. gδ3 39. ,760 33. ,585 1.00 33, .48 E
ATOM 8406 o ASP 482 144. goo 40. ,179 33. ,976 1.00 33, .4δ E
ATOM 8407 N LEU 483 146.6δ7 40. ,362 32. ,642 1.00 33, ,4δ E
ATOM 8408 CA LEU 483 146.154 41. ,566 32. ,061 1.00 33, .4δ E
ATOM 8409 CB LEU 4δ3 147.12g 42. ,177 31. ,058 1.00 33 .4δ E
ATOM 8410 CG LEU 4δ3 146.781 43. ,616 30. ,659 1.00 33, .4δ E
ATOM 8411 CDl LEU 4δ3 145. g72 43. ,602 29. ,418 1.00 33 .4δ E
ATOM 8412 CD2 LEU 4δ3 146.025 44. ,311 31. ,769 1.00 33, .48 E
ATOM 8413 C LEU 4δ3 144.831 41. ,253 31. ,405 1.00 33 .48 E
ATOM 8414 O LEU 4δ3 144.758 40. .479 30. .456 1.00 33 .48 E
ATOM δ415 N ALA 4δ4 143.782 41. .862 31. .941 1.00 33 .4δ E
ATOM 8416 CA ALA 4δ4 142.441 41. .686 31. .429 1.00 33 .4δ E
ATOM 8417 CB ALA 4δ4 141.949 40, ,268 31. .707 1.00 33 .4δ E
ATOM 8418 C ALA 4δ4 141.521 42, .701 32. .080 1.00 33 .4δ E
ATOM 8419 O ALA 4δ4 141.598 42, ,95g 33, .277 1.00 33 .4δ E
ATOM 8420 N ALA 4δ5 140.642 43, .265 31. ,268 1.00 33 .4δ E
ATOM 8421 CA ALA 4δ5 139.699 44, .270 31. ,713 1.00 33 .4δ E
ATOM 8422 CB ALA 4δ5 138.634 44, ,46g 30. ,648 1.00 33, .4δ E
ATOM 8423 C ALA 485 139.045 43, ,g58 33. ,053 1.00 33 ,4δ E
ATOM 8424 O ALA 485 138.265 44, .766 33, ,564 1.00 33 .4δ E
ATOM 8425 N ARG 4δ6 139.350 42. .δOO 33. ,629 1.00 33, .4δ E
ATOM 8426 CA ARG 486 138.749 42. .426 34. .903 1.00 33 .4δ E
ATOM 8427 CB ARG 486 138.454 40. ,g26 34. ,g33 1.00 33, .48 E
ATOM δ428 CG ARG 4δ6 13g.531 40. .Oδl 35. ,607 1.00 33 .48 E
ATOM 8429 CD ARG 4δ6 13g.076 3δ. .632 35. ,760 1.00 33, .48 E
ATOM 8430 NE ARG 4δ6 13g.202 37. .862 34. ,523 1.00 33 .48 E
ATOM 8431 CZ ARG 486 140.270 37, .135 34. .205 1.00 33 .4δ E
ATOM 8432 NHl ARG 486 141.310 37, .070 35, ,034 1.00 33 .4δ E
ATOM 8433 NH2 ARG 486 140.303 36. .474 33, .057 1.00 33 .4δ E
ATOM 8434 C ARG 486 13g.663 42, .804 36. .055 1.00 33 .4δ E
ATOM 8435 O ARG 486 13g.244 42, .824 37, ,204 1.00 33 .4δ E
ATOM 8436 N ASN 487 140.918 43, .ogδ 35, .733 1.00 33 .48 E
ATOM 8437 CA ASN 487 141.900 43, .504 36. .730 1.00 33 .48 E
ATOM 843δ CB ASN 487 143.123 42, .593 36, ,700 1.00 33 .48 E
ATOM 8439 CG ASN 4δ7 142.767 41, .166 36. ,gδo 1.00 33, .48 E
ATOM 8440 ODl ASN 4δ7 141.722 40, .897 37, ,566 1.00 33 .48 E
ATOM δ441 ND2 ASN 4δ7 143.630 40, .235 36, ,575 1.00 33 .4δ E
ATOM δ442 C ASN 4δ7 142.317 44, .930 36, ,444 1.00 33, .4δ E ATOM δ443 0 ASN 487 143.408 45.363 36.781 1.0033,,48 E
ATOM 8444 N CYS 488 141.430 45. 650 35. 787 1.00 33. ,48 E
ATOM 8445 CA CYS 488 141.659 47. ,035 35. 472 1.00 33. ,48 E
ATOM 8446 CB CYS 488 141.487 47. ,254 33. g77 1.00 33. ,48 E
ATOM 8447 SG CYS 488 142.921 46. ,728 33. 061 1.00 33. .48 E
ATOM 8448 C CYS 488 140.626 47. ,814 36. 270 1.00 33. .48 E
ATOM 844g 0 CYS 488 139.453 47. ,443 36. ,315 1.00 33. .48 E
ATOM δ450 N LEU 489 141.070 48. ,881 36. ,919 1.00 33, .48 E
ATOM δ451 CA LEU 489 140. lδ3 49. ,700 37. ,72g 1.00 33, .48 E
ATOM 8452 CB LEU 489 140.791 49. ,855 3g. ,121 1.00 33, .48 E
ATOM 8453 CG LEU 489 140.7δ3 48. ,515 3g. ,864 1.00 33, .48 E
ATOM δ454 CDl LEU 489 141.924 48. ,416 40. ,850 1.00 33, .48 E
ATOM δ455 CD2 LEU 489 13g.457 48. ,360 40. ,560 1.00 33. .48 E
ATOM δ456 C LEU 489 13g.g43 51. ,054 37. ,066 1.00 33, .48 E
ATOM δ457 0 LEU 489 140.77g 51. ,534 36. ,308 1.00 33, .48 E
ATOM 8458 N VAL 490 i3δ.78g 51. .654 37. ,332 1.00 33, .48 E
ATOM 845g CA VAL 490 138.44g 52. .938 36. ,748 1.00 33, .48 E
ATOM δ460 CB VAL 490 136.999 52. , 46 36. ,218 1.00 33, .48 E
ATOM δ461 CGl VAL 490 136.781 54. ,12g 35. ,305 1.00 33, .48 E
ATOM δ462 CG2 VAL 490 136.702 51, .668 35. .481 1.00 33 .48 E
ATOM δ463 C VAL 490 138.563 53, .gδδ 37. ,831 1.00 33 .48 E
ATOM 8464 0 VAL 490 137.885 53, .8g3 38. .851 1.00 33 .48 E
ATOM 8465 N GLY 491 139.422 54, ,gδ4 37. .611 1.00 33, .48 E
ATOM 8466 CA GLY 491 139.606 56, .060 38. .576 1.00 33 .48 E
ATOM 8467 C GLY 491 138.974 57, .402 38. .203 1.00 33 .48 E
ATOM 846δ 0 GLY 491 138.005 57, ,47g 37, ,442 1.00 33 .48 E
ATOM δ469 N GLU 492 139.531 58, ,47g 38, .738 1.00 33 .48 E
ATOM δ470 CA GLU 492 138. gs 59, .811 38, ,474 1.00 33 .48 E
ATOM δ471 CB GLU 492 13g.773 60, .867 3g, ,273 1.00 33 .48 E
ATOM δ472 CG GLU 492 13g.573 60, .772 40, .784 1.00 33 .48 E
ATOM δ473 CD GLU 492 140.175 61, . 57 41, .536 1.00 33 .48 E
ATOM δ474 OEl GLU 492 i3g.6gι 63, .102 41, .345 1.00 33 .48 E
ATOM 8475 OE2 GLU 492 141.130 61, ,72g 42. ,320 1.00 33, .48 E
ATOM 8476 C GLU 492 138. g63 60, .230 37, ,011 1.00 33 .48 E
ATOM δ477 0 GLU 492 139.971 60, .172 36, ,■312 1.00 33 .48 E
ATOM δ478 N ASN 493 137.787 60, .67g 36, ,57g 1.00 33 .48 E
ATOM 8479 CA ASN 493 137.571 61, .135 35. .216 1.00 33 .48 E
ATOM 8480 CB ASN 493 13δ.665 62 .110 34. .787 1.00 33 .48 E
ATOM 84δl CG ASN 493 13δ.895 63 .215 35, ,7g7 1.00 33 .48 E
ATOM δ4δ2 ODl ASN 493 13g.875 63 .186 36, .560 1.00 33 .48 E
ATOM δ4δ3 ND2 ASN 493 137. ggi 64 .198 35, .818 1.00 33 .48 E
ATOM δ4δ4 C ASN 493 137.5δδ 59 .g48 34, .282 1.00 33 .48 E
ATOM 8485 0 ASN 493 137.703 60 .108 33, .062 1.00 33 .48 E
ATOM 8486 N GLN 494 137.4δ5 58, .760 34, .866 1.00 33 .48 E ATOM 8487 CA GLN 4g4 137.,495 57.,526 34,.103 1.00 33,.4δ E
ATOM 848δ CB GLN 4g4 136. ,650 57. ,656 32, ,δ47 1.00 33, .4δ E
ATOM δ4δg CG GLN 4g4 135. ,206 57. ,g65 33, ,0δ6 1.00 33, .4δ E
ATOM δ4go CD GLN 44 134. ,461 58. ,002 31, .785 1.00 33, .4δ E
ATOM 4gι OEl GLN 494 134. ,864 58. ,713 30. ,863 1.00 33, ,4δ E
ATOM 4 2 NE2 GLN 494 133. ,374 57. ,238 31, ,683 1.00 33, .48 E
ATOM 84g3 C GLN 494 138. ,887 57. ,130 33, .688 1.00 33, .48 E
ATOM 44 O GLN 494 139. ,083 56. ,686 32, .572 1.00 33, .48 E
ATOM 84g5 N VAL 4g5 139. ,863 57. ,314 34, .563 1.00 33, .48 E
ATOM 84g6 CA VAL 4g5 141. ,229 56. ,g27 34, .249 1.00 33 .48 E
ATOM 4g7 CB VAL 4g5 142. ,237 57, ,512 35, ,249 1.00 33, .48 E
ATOM δ4g CGl VAL 4g5 143. ,622 56, ,g83 34, .971 1.00 33 .48 E
ATOM 4gg CG2 VAL 4g5 142. ,233 sg. .010 35, .162 1.00 33, .48 E
ATOM 8500 C VAL 4g5 141. ,255 55, ,42g 34, .434 1.00 33 .4δ E
ATOM 8501 0 VAL 4g5 140, ,529 54, ,go2 35, .274 1.00 33 .4δ E
ATOM δ502 N ILE 4gε 142. ,071 54, .733 33, .655 1.00 33, .48 E
ATOM δ503 CA ILE 4g6 142, ,178 53. ,2g5 33, .820 1.00 33, .48 E
ATOM 8504 CB ILE 496 141, .979 52, .536 32, .493 1.00 33 .48 E
ATOM 8505 CG2 ILE 496 142, ,011 51. .050 32, .746 1.00 33, ,48 E
ATOM 8506 CGl ILE 496 140, .637 52. ,go2 31, .875 1.00 33, .48 E
ATOM 8507 CDl ILE 496 139. ,465 52. ,562 32, .762 1.00 33, ,4δ E
ATOM 8508 C ILE 496 143. ,563 52. , 82 34, .359 1.00 33, .4δ E
ATOM ssog 0 ILE 496 144. ,566 53. .413 33, .798 1.00 33, .48 E
ATOM 8510 N LYS 497 143. .613 52. ,252 35, .463 1.00 33, .48 E
ATOM 8511 CA LYS 497 144. ,8δ7 51. ,δ5δ 36, .043 1.00 33, .48 E
ATOM δ512 CB LYS 4g7 145. ,041 52, .415 37, .466 1.00 33, .48 E
ATOM 8513 CG LYS 497 145. ,191 53, .giδ 37, .515 1.00 33, .48 E
ATOM 8514 CD LYS 497 145, ,4δ4 54, .441 38, .918 1.00 33 .48 E
ATOM 8515 CE LYS 4g7 145. ,747 55. ,g47 38, ,880 1.00 33, .48 E
ATOM 8516 NZ LYS 47 145, ,9δl 56. .532 40, .218 1.00 33, .48 E
ATOM 8517 C LYS 4g7 145, .021 50. .334 36, .053 1.00 33 .48 E
ATOM 851δ 0 LYS 4g7 144, .036 4g, .605 36, .164 1.00 33, .48 E
ATOM δ5ig N VAL 4 δ 146, .255 4g. ,δ66 35, .928 1.00 33, .48 E
ATOM δ520 CA VAL 4gδ 146. .535 4δ. .451 35, .914 1.00 33 .48 E
ATOM δ521 CB VAL 4 δ 147. .743 4δ, ,158 35, .050 1.00 33, .48 E
ATOM δ522 CGl VAL 4gδ 148, .203 46, ,736 35, .270 1.00 33, .48 E
ATOM 8523 CG2 VAL 4gδ 147. ,381 4δ. ,360 33, ,612 1.00 33, .48 E
ATOM 8524 C VAL 4gδ 146. ,7g6 47. ,g24 37, ,30δ 1.00 33, .48 E
ATOM 8525 0 VAL 4gδ 147. .550 48. ,511 3δ, .064 1.00 33, .48 E
ATOM 8526 N SER 4g 146. ,168 46. ,801 37. ,641 1.00 33, .48 E
ATOM 8527 CA SER 4gg 146. ,340 46. ,ιg3 3δ. ,952 1.00 33, .48 E
ATOM δ52δ CB SER 4gg 145. ,058 46. ,302 3g. .775 1.00 33, .48 E
ATOM δ52g OG SER 4gg 143. ,g33 45. ,goι 39. .013 1.00 33, .48 E
ATOM 8530 C SER 49 146. ,783 44. ,743 38. ,δ88 1.00 33, .48 E ATOM 8531 0 SER 4g9 146.,835 44.136 37.826 1.00 33.,4δ E
ATOM 8532 N ASP 500 147. ,096 44. ,216 40. ,064 1.00 33. ,4δ E
ATOM 8533 CA ASP 500 147. ,583 42. ,860 40. 259 1.00 33. .48 E
ATOM 8534 CB ASP 500 146. ,676 41. ,δ40 3g. ,598 1.00 33, .48 E
ATOM 8535 CG ASP 500 145. ,704 41. ,227 40. 589 1.00 33, ,48 E
ATOM 8536 ODl ASP 500 146. ,169 40. ,531 41. ,527 1.00 33, .48 E
ATOM 8537 OD2 ASP 500 144. ,474 41. ,442 40. ,440 1.00 33, ,48 E
ATOM 8538 C ASP 500 149. ,008 42. ,661 3g. 798 1.00 33, .48 E
ATOM 853g 0 ASP 500 149. ,944 42. ,g32 40. ,550 1.00 33, .48 E
ATOM 8540 N PHE 501 149. ,171 42. ,2og 3δ. ,564 1.00 33, .48 E
ATOM 8541 CA PHE 501 150. ,494 41. ,g44 3δ. ,016 1.00 33, .48 E
ATOM 8542 CB PHE 501 151. ,067 43. ,202 37. ,341 1.00 33, ,4δ E
ATOM 8543 CG PHE 501 150. .977 44. ,450 3δ. ,172 1.00 33, ,4δ E
ATOM 8544 CDl PHE 501 152. ,010 44. ,8og 3g. ,028 1.00 33, ,4δ E
ATOM 8545 CD2 PHE 501 149. ,δ44 45. ,246 38. ,114 1.00 33, ,4δ E
ATOM 8546 CEl PHE 501 151. .907 45. ,g28 39. ,804 1.00 33, ,4δ E
ATOM 8547 CE2 PHE 501 149, .739 46. ,367 38. .891 1.00 33, ,4δ E
ATOM 8548 CZ PHE 501 150, .768 46. ,710 39. ,737 1.00 33, ,4δ E
ATOM 8549 C PHE 501 151, .470 41, ,361 39. ,032 1.00 33, ,4δ E
ATOM 8550 0 PHE 501 151, .866 42, ,oog 39. ,9 2 1.00 33, ,4δ E
ATOM δ551 N GLY 502 151, .843 40, ,107 38, ,7g5 1.00 33, ,4δ E
ATOM 8552 CA GLY 502 152, .751 39, ,3g8 39. ,683 1.00 33, ,4δ E
ATOM 8553 C GLY 502 151, .976 38, .406 40. ,539 1.00 33, ,4δ E
ATOM 8554 0 GLY 502 151, .942 37. .208 40, .247 1.00 33, .48 E
ATOM 8555 N PHE 520 140, .457 29, .455 34, .954 1.00 33, .48 E
ATOM 8556 CA PHE 520 141, .587 29, .470 34, .024 1.00 33, .48 E
ATOM δ557 CB PHE 520 141, .789 28, .083 33, ,420 1.00 33, .48 E
ATOM δ55δ CG PHE 520 142, .090 27, .047 34, ,447 1.00 33, .48 E
ATOM δ559 CDl PHE 520 141, .063 26, .359 35. ,074 1.00 33, .48 E
ATOM δ560 CD2 PHE 520 143, .395 26, ,δ50 34, ,87δ 1.00 33, .48 E
ATOM 8561 CEl PHE 520 141, .330 25, .500 36. ,117 1.00 33, .48 E
ATOM 8562 CE2 PHE 520 143, .671 25, .9g3 35. ,91δ 1.00 33, .48 E
ATOM 8563 CZ PHE 520 142, .639 25, .317 36. ,542 1.00 33, ,4δ E
ATOM 8564 C PHE 520 141, .428 30, .513 32. ,930 1.00 33, .48 E
ATOM 8565 0 PHE 520 140, .441 30, ,524 32. ,191 1.00 33, .48 E
ATOM 8566 N PRO 521 142, .425 31, .400 32, ,808 1.00 33, .48 E
ATOM 8567 CD PRO 521 143, .618 31, ,37g 33, ,673 1.00 33, .48 E
ATOM δ568 CA PRO 521 142, .514 32, .505 31, ,855 1.00 33, .48 E
ATOM 856g CB PRO 521 143, .431 33, ,461 32, ,5δ0 1.00 33, .48 E
ATOM 8570 CG PRO 521 144, .448 32, ,511 33, ,105 1.00 33 .48 E
ATOM 8571 C PRO 521 143, .050 32, ,lδl 30, .465 1.00 33 .4δ E
ATOM 8572 0 PRO 521 143, .7δ5 32, ,gg4 29, .891 1.00 33, .48 E
ATOM 8573 N VAL 522 142, .701 31, .034 29, .897 1.00 33 .48 E
ATOM 8574 CA VAL 522 143, .251 30, ,737 28. ,5δ2 1.00 33, .48 E ATOM 8575 CB VAL 522 142.,972 29.268 28.,148 1.00 33,.48 E
ATOM 8576 CGl VAL 522 143. ,356 28.327 29. ,277 1.00 33, .48 E
ATOM 8577 CG2 VAL 522 141. ,517 29.08δ 27. ,749 1.00 33. ,48 E
ATOM 857δ C VAL 522 142. ,697 31.720 27. ,562 1.00 33. ,48 E
ATOM δ579 0 VAL 522 143. ,395 32.130 26. ,639 1.00 33, .48 E
ATOM 8580 N LYS 523 141. ,44δ 32.116 27. ,746 1.00 33, .48 E
ATOM 8581 CA LYS 523 140. .819 33.06δ 26. ,836 1.00 33, .48 E
ATOM 85δ2 CB LYS 523 139. .532 33.5go 27. ,462 1.00 33, .48 E
ATOM δ5δ3 CG LYS 523 138. ,568 32.501 27. ,892 1.00 33, .48 E
ATOM 8584 CD LYS 523 137. ,6go 32.070 26. ,740 1.00 33, .48 E
ATOM 8585 CE LYS 523 136. ,6g8 31.020 27. .185 1.00 33, .48 E
ATOM 8586 NZ LYS 523 135, ,640 30.δ03 26. ,164 1.00 33, .48 E
ATOM 85δ7 C LYS 523 141, ,757 34.247 26. ,546 1.00 33, .48 E
ATOM δ5δδ 0 LYS 523 141. ,δ4δ 34.724 25. ,418 1.00 33, .48 E
ATOM 5δ N TRP 524 142, ,456 34.702 27. ,579 1.00 33, .48 E
ATOM δsgo CA TRP 524 143, ,3δ5 35.δl7 27. ,464 1.00 33, .48 E
ATOM δsgi CB TRP 524 143, .345 36.648 28. .736 1.00 33, .48 E
ATOM δ5 2 CG TRP 524 142, ,112 37.451 2δ. .863 1.00 33, .48 E
ATOM δ5g3 CD2 TRP 524 140, .877 37.027 29. .430 1.00 33, .48 E
ATOM δ5g4 CE2 TRP 524 13g, .ggs 3δ.ιιg 29. .369 1.00 33, .48 E
ATOM 8595 CE3 TRP 524 140, .430 35.δ30 29. .989 1.00 33, .48 E
ATOM 8596 CDl TRP 524 141, .936 3δ.747 28. .483 1.00 33, .48 E
ATOM 8597 NEl TRP 524 140, .668 3g.i5g 28. ,786 1.00 33, .48 E
ATOM 8598 CZ2 TRP 524 138, .689 38.04g 29. ,850 1.00 33, .48 E
ATOM 859g CZ3 TRP 524 139, .142 35.763 30. ,463 1.00 33, .48 E
ATOM 8600 CH2 TRP 524 138, .284 36.865 30, ,393 1.00 33, .48 E
ATOM 8601 C TRP 524 144, ,820 35.385 27, ,202 1.00 33, .48 E
ATOM 8602 0 TRP 524 145, ,663 36.205 26, ,δ43 1.00 33, .48 E
ATOM 8603 N ALA 525 145, ,og7 34.100 27. ,375 1.00 33, .48 E
ATOM 8604 CA ALA 525 146, .446 33.600 27. ,175 1.00 33, .48 E
ATOM 8605 CB ALA 525 146, .650 32.325 27. ,9δ9 1.00 33 .48 E
ATOM 8606 C ALA 525 146, .821 33.359 25. ,714 1.00 33, .48 E
ATOM 8607 0 ALA 525 146, .067 32.770 24. ,945 1.00 33, .48 E
ATOM 8608 N SER 526 148, .004 33.830 25, ,342 1.00 33, .48 E
ATOM 860g CA SER 526 148, .510 33.653 23, .991 1.00 33, .48 E
ATOM δ610 CB SER 526 149, .886 34.295 23, ,δ4δ 1.00 33, .48 E
ATOM 8611 OG SER 526 150, .875 33.473 24, ,444 1.00 33, .48 E
ATOM 8612 C SER 526 148, .675 32.163 23. ,757 1.00 33, .48 E
ATOM 8613 0 SER 526 148. .44δ 31.354 24. ,65δ 1.00 33, .48 E
ATOM 8614 N PRO 527 14g, .072 31.777 22. ,535 1.00 33, .48 E
ATOM 8615 CD PRO 527 14g, .198 32.495 21. ,256 1.00 33, .48 E
ATOM 8616 CA PRO 527 149, .235 30.342 22. ,344 1.00 33, .48 E
ATOM 8617 CB PRO 527 149, .344 30.200 20. ,δ29 1.00 33, .48 E
ATOM δ61δ CG PRO 527 149, .924 31.487 20. ,402 1.00 33, .48 E ATOM 86ig C PRO 527 150.,466 2g,,855 23.,101 1.0033,.48 E
ATOM δ620 0 PRO 527 150. ,328 2g, ,132 24. ,076 1.00 33, .48 E
ATOM δ621 N GLU 528 151. ,655 30. ,288 22. ,696 1.00 33, ,4δ E
ATOM δ622 CA GLU 528 152. ,877 2g, ,837 23. ,350 1.00 33, ,4δ E
ATOM δ623 CB GLU 528 154. ,043 30. ,δ04 23. ,094 1.00 33, ,4δ E
ATOM 8624 CG GLU 52δ 154. ,183 31. , g7 24. ,09g 1.00 33, .48 E
ATOM 8625 CD GLU 52δ 153. .sgg 33. ,24g 23. ,502 1.00 33, .48 E
ATOM 8626 OEl GLU 52δ 153. ,176 33. .300 22. ,487 1.00 33, ,4δ E
ATOM 8627 OE2 GLU 52δ 154. ,381 34, .262 24. ,046 1.00 33, .4δ E
ATOM 8628 C GLU 52δ 152. ,712 2g, .614 24. ,856 1.00 33, .48 E
ATOM 862g 0 GLU 52δ 153. ,385 2δ, ,75g 25. ,434 1.00 33, .48 E
ATOM δ630 N VAL 52g 151. ,δl7 30, ,351 25. ,506 1.00 33, .48 E
ATOM δ631 CA VAL 52g 151. ,653 30, .141 26, ,g38 1.00 33, .48 E
ATOM δ632 CB VAL 52g 151. .154 31, .421 27, ,67g 1.00 33, ,4δ E
ATOM δ633 CGl VAL 52g 152. .301 32, .412 27, ,838 1.00 33, .48 E
ATOM 8634 CG2 VAL 52g 150. .000 32, .053 26. ,g25 1.00 33, .48 E
ATOM 8635 C VAL 52 150. .717 2δ, ,gg3 27, .272 1.00 33, .4δ E
ATOM 8636 0 VAL 52g 151. .065 2δ, .133 2δ, ,06g 1.00 33, .4δ E
ATOM 8637 N PHE 530 14g. ,534 2δ, .966 26, .664 1.00 33, ,4δ E
ATOM 8638 CA PHE 530 14δ. .603 27, .892 26, ,g77 1.00 33, ,4δ E
ATOM 863g CB PHE 530 147, .175 2δ, ,18δ 26, ,500 1.00 33, ,4δ E
ATOM δ640 CG PHE 530 147. ,027 2δ, ,330 25. ,023 1.00 33, .48 E
ATOM δ641 CDl PHE 530 147, ,532 27, ,3δ3 24, ,15g 1.00 33, .48 E
ATOM δ642 CD2 PHE 530 146, .306 2g, .389 24, ,4gδ 1.00 33, .4δ E
ATOM 8643 CEl PHE 530 147, .315 27, .485 22, ,7g7 1.00 33, .4δ E
ATOM 8644 CE2 PHE 530 146, .085 2g, .497 23, .136 1.00 33, ,4δ E
ATOM 8645 CZ PHE 530 146, .586 2δ, .546 22, .285 1.00 33, .48 E
ATOM 8646 C PHE 530 14g, .osg 26, .603 26, ,3g3 1.00 33, .48 E
ATOM 8647 0 PHE 530 14δ, ,401 25, .600 26, .428 1.00 33, ,4δ E
ATOM δ64δ N SER 531 150, ,2g6 26, .642 25, ,δ61 1.00 33, .48 E
ATOM 864g CA SER 531 150. ,gi7 25, .474 25. ,27g 1.00 33, .48 E
ATOM 8650 CB SER 531 151. .345 25, .783 23. .845 1.00 33, .48 E
ATOM δ651 OG SER 531 150. ,23g 26, .261 23. ,080 1.00 33, ,4δ E
ATOM 8652 C SER 531 152, .lig 25, .118 26. .147 1.00 33, ,4δ E
ATOM 8653 0 SER 531 152, .lsg 24, ,046 26. ,740 1.00 33, ,4δ E
ATOM 8654 N PHE 532 153, ,07g 26. ,033 26, ,260 1.00 33, ,4δ E
ATOM δ655 CA PHE 532 154, ,271 25, ,772 27, ,063 1.00 33, .48 E
ATOM 8656 CB PHE 532 155, .522 25, ,864 26, ,ιg5 1.00 33, .48 E
ATOM 8657 CG PHE 532 155, ,305 25. ,422 24, ,7δg 1.00 33, .48 E
ATOM 8658 CDl PHE 532 155, ,ιgo 24. ,085 24, ,4δl 1.00 33, ,4δ E
ATOM 865g CD2 PHE 532 155, .166 26. .353 23, ,776 1.00 33, .48 E
ATOM δ660 CEl PHE 532 154, ,g38 23, .681 23, ,lδl 1.00 33, .48 E
ATOM 8661 CE2 PHE 532 154, ,gi5 25, .961 22, ,4δ3 1.00 33, .48 E
ATOM 8662 CZ PHE 532 154. ,δ00 24, ,618 22, ,180 1.00 33, ,48 E ATOM 8663 C PHE 532 154.,457 26.,702 2δ.,257 1.00 33,.4δ E
ATOM 8664 0 PHE 532 155. .522 26. ,705 28. ,δ65 1.00 33, .48 E
ATOM 8665 N SER 533 153. ,452 27. ,495 28. ,607 1.00 33, .48 E
ATOM 8666 CA SER 533 153. .622 28. ,391 29, ,753 1.00 33, .48 E
ATOM 8667 CB SER 533 153. .566 27. ,592 31. ,061 1.00 33, .48 E
ATOM 8668 OG SER 533 152. .229 27. ,240 31. ,4og 1.00 33, .48 E
ATOM 866g C SER 533 154. .964 2g. ,110 29. ,65g 1.00 33 .48 E
ATOM 8670 0 SER 533 155. ,78δ 2g. ,011 30. ,557 1.00 33, .48 E
ATOM 8671 N ARG 534 155. .169 2g. ,826 2δ. ,558 1.00 33 .48 E
ATOM 8672 CA ARG 534 156, .403 30. .566 2δ. ,295 1.00 33 .4δ E
ATOM 8673 CB ARG 534 156, .877 30. ,223 26. ,871 1.00 33 .4δ E
ATOM 8674 CG ARG 534 158, .214 30. .806 26. ,425 1.00 33 .4δ E
ATOM 8675 CD ARG 534 158, .258 31. .042 24. ,882 1.00 33 .4δ E
ATOM 8676 NE ARG 534 158, .206 2g. .809 24. ,079 1.00 33 .48 E
ATOM 8677 CZ ARG 534 158, ,048 2g. .765 22. ,749 1.00 33 .48 E
ATOM 8678 NHl ARG 534 157, .919 30. .893 22. ,048 1.00 33, .48 E
ATOM 867g NH2 ARG 534 158, .018 28. .584 22. ,119 1.00 33 .48 E
ATOM 8680 C ARG 534 156, .070 32. .060 2δ. .415 1.00 33 .48 E
ATOM 8681 0 ARG 534 156, .146 32. .798 27. .436 1.00 33, .48 E
ATOM 8682 N TYR 535 155, ,69g 32, ,496 29. ,618 1.00 33 .48 E
ATOM 8683 CA TYR 535 155, .313 33. ,8δ9 29. ,δ75 1.00 33, .48 E
ATOM 8684 CB TYR 535 154, .sgg 34, .054 31. .329 1.00 33, .48 E
ATOM 8685 CG TYR 535 153, .sgo 33, .406 31. .668 1.00 33 .48 E
ATOM 8686 CDl TYR 535 152, ,3g5 33, ,g6δ 31. .258 1.00 33, .4δ E
ATOM 8687 CEl TYR 535 151, ,ιg2 33, .365 31. .542 1.00 33 .4δ E
ATOM 868δ CD2 TYR 535 153, .548 32, .213 32. .376 1.00 33 .48 E
ATOM 86δg CE2 TYR 535 152, .342 31, ,5g4 32. .661 1.00 33 .48 E
ATOM 8690 CZ TYR 535 151, .lεg 32, .177 32. .241 1.00 33 .48 E
ATOM 8691 OH TYR 535 149. .g64 31, .566 32. .506 1.00 33 .48 E
ATOM 8692 C TYR 535 156, .373 34, .930 29. .573 1.00 33 .48 E
ATOM 8693 0 TYR 535 157, .543 34, ,746 29, ,910 1.00 33 .48 E
ATOM 8694 N SER 536 155, ,g57 36, ,038 2δ. .962 1.00 33, .48 E
ATOM 8695 CA SER 536 156, .887 37, .119 28, ,629 1.00 33 .48 E
ATOM 8696 CB SER 536 157, .733 36. .741 27. ,417 1.00 33, .48 E
ATOM 8697 OG SER 536 156, ,g40 36. .742 26. ,247 1.00 33, .48 E
ATOM 8698 C SER 536 156, .132 38. .404 28. ,318 1.00 33 .48 E
ATOM 869g 0 SER 536 154, ,g4i 38. .366 2δ. ,027 1.00 33, .48 E
ATOM 8700 N SER 537 156, ,δ23 39. .539 2δ. ,363 1.00 33, .48 E
ATOM 8701 CA SER 537 156, .158 40. .803 2δ. ,084 1.00 33 .48 E
ATOM 8702 CB SER 537 157, .166 41, .959 2δ. ,005 1.00 33, .48 E
ATOM 8703 OG SER 537 156, ,g47 42, ,δ97 2g. ,050 1.00 33, .48 E
ATOM 8704 C SER 537 155. .386 40. .700 26. ,782 1.00 33, .48 E
ATOM 8705 0 SER 537 154, .301 41, .261 26. ,656 1.00 33, .48 E
ATOM 8706 N LYS 538 155, ,g4i 39, ,9δ3 25. ,811 1.00 33, .48 E ATOM 8707 CA LYS 538 155..251 3g,.δ25 24,.53δ 1.0033.48 E
ATOM 8708 CB LYS 538 156, .135 39, .110 23, .517 1.00 33 .4δ E
ATOM 870g CG LYS 53δ 157, .118 40, .035 22, ,δ41 1.00 33 .4δ E
ATOM 8710 CD LYS 53δ 156. .366 41, .139 22, .132 1.00 33, .4δ E
ATOM 8711 CE LYS 53δ 157. .307 42, .139 21, .492 1.00 33 .4δ E
ATOM 8712 NZ LYS 538 158. ,211 41, .492 20, .511 1.00 33 .4δ E
ATOM 8713 C LYS 538 153. ,9g5 39, .029 24, .δOδ 1.00 33, .4δ E
ATOM 8714 0 LYS 538 152. ,g52 3g, .264 24, .204 1.00 33 .4δ E
ATOM 8715 N SER 53g 154. ,og4 38, .0δ6 25, .731 1.00 33 .4δ E
ATOM 8716 CA SER 53g 152. ,g28 37, .309 26. ,06δ 1.00 33, .4δ E
ATOM 8717 CB SER 539 153. ,246 36, .294 27, .155 1.00 33, ,4δ E
ATOM 8718 OG SER 539 152, .iog 35, .479 27, .381 1.00 33 .4δ E
ATOM 87ig C SER 539 151, ,8 6 38, .306 26, .562 1.00 33, .4δ E
ATOM 8720 0 SER 539 150. .718 3δ, .188 26, .244 1.00 33, .4δ E
ATOM 8721 N ASP 540 152. ,342 3g, ,296 27, ,334 1.00 33, .4δ E
ATOM 8722 CA ASP 540 151, .432 40, .325 27, ,δ26 1.00 33 .48 E
ATOM 8723 CB ASP 540 152, .167 41, .443 28, .570 1.00 33 .48 E
ATOM 8724 CG ASP 540 152, .708 41, .009 29, .927 1.00 33, .48 E
ATOM 8725 ODl ASP 540 153, ■ δlO 40, .418 29, ,96g 1.00 33 .48 E
ATOM 8726 OD2 ASP 540 152, .035 41, .266 30, .952 1.00 33 .48 E
ATOM 8727 C ASP 540 150, ,74g 40, .941 26, ,620 1.00 33 .48 E
ATOM 8728 0 ASP 540 149. ,533 40, .gis 26, ,501 1.00 33, .48 E
ATOM 872g N VAL 541 151. ,542 41, ,4 6 25, .716 1.00 33 .48 E
ATOM 8730 CA VAL 541 150, ,g87 42. .115 24, .531 1.00 33, .48 E
ATOM 8731 CB VAL 541 152. ,035 42, .234 23, .426 1.00 33, .48 E
ATOM 8732 CGl VAL 541 151, ,357 42, .567 22, ,09δ 1.00 33, .48 E
ATOM 8733 CG2 VAL 541 153, ,033 43, ,2gg 23, ,7g6 1.00 33, .48 E
ATOM 8734 C VAL 541 149. ,7go 41, .358 23. ,gδi 1.00 33, ,4δ E
ATOM 8735 0 VAL 541 148. ,762 41. ,g58 23. ,668 1.00 33, ,4δ E
ATOM 8736 N TRP 542 149. .gig 40. .040 23. ,865 1.00 33, .48 E
ATOM 8737 CA TRP 542 148. ,827 3g. .247 23. ,339 1.00 33, .48 E
ATOM 8738 CB TRP 542 149. ,164 37. ,743 23. ,369 1.00 33, .48 E
ATOM 873g CG TRP 542 147. ,ggo 36. ,86g 22. ,981 1.00 33, .48 E
ATOM 8740 CD2 TRP 542 147. ,7g7 36. ,174 21. ,748 1.00 33, .48 E
ATOM 8741 CE2 TRP 542 146. ,502 35. ,632 21. ,775 1.00 33, .48 E
ATOM 8742 CE3 TRP 542 148. ,58g 35. ,961 20. ,621 1.00 33, .48 E
ATOM 8743 CDl TRP 542 146. ,841 36. ,705 23. ,686 1.00 33, .48 E
ATOM 8744 NEl TRP 542 145. , 43 35, ,975 22. ,g72 1.00 33, .48 E
ATOM 8745 CZ2 TRP 542 145. ,g78 34. ,895 20. ,727 1.00 33, .48 E
ATOM 8746 CZ3 TRP 542 148. ,066 35. ,226 19. ,581 1.00 33, .48 E
ATOM 8747 CH2 TRP 542 146. ,772 34. ,703 19. ,642 1.00 33, .48 E
ATOM 8748 C TRP 542 147. ,sg2 3g. ,549 24. ,176 1.00 33, ,4δ E
ATOM 874g 0 TRP 542 146. ,544 39. ,923 23. ,642 1.00 33, ,4δ E
ATOM 8750 N SER 543 147. ,712 39. ,403 25. ,4g2 1.00 33, ,4δ E ATOM δ751 CA SER 543 146,.578 3g,.677 26,.370 1.00 33,.48 E
ATOM 8752 CB SER 543 146, .950 3g, .384 27. .819 1.00 33, .48 E
ATOM 8753 OG SER 543 147, .448 3δ, .065 27. .928 1.00 33, .48 E
ATOM 8754 C SER 543 146, .104 41, .122 26, .238 1.00 33 .48 E
ATOM 8755 0 SER 543 144, .934 41, .411 26. ,457 1.00 33, .48 E
ATOM δ756 N PHE 544 147, .017 42, .028 25, ,892 1.00 33 .48 E
ATOM 8757 CA PHE 544 146, ,653 43, .421 25, ,717 1.00 33 .48 E
ATOM 8758 CB PHE 544 147, .872 44, .251 25, .308 1.00 33 .48 E
ATOM 8759 CG PHE 544 147, .543 45, .685 24, .968 1.00 33 .48 E
ATOM 8760 CDl PHE 544 147, .254 46, .sgg 25, .960 1.00 33 .48 E
ATOM 8761 CD2 PHE 544 147, .464 46, ,099 23, .642 1.00 33 .48 E
ATOM 8762 CEl PHE 544 146, .890 47, .886 25, .636 1.00 33 .48 E
ATOM 8763 CE2 PHE 544 147, .ogδ 47, .389 23, .318 1.00 33, .48 E
ATOM 8764 CZ PHE 544 146, .δll 48, .279 24, .310 1.00 33 .48 E
ATOM 8765 C PHE 544 145, .607 43, ,455 24. ,610 1.00 33, .48 E
ATOM 8766 0 PHE 544 144, .600 44, .159 24. ,69g 1.00 33 .48 E
ATOM 8767 N GLY 545 145, .853 42, ,669 23. ,56g 1.00 33, .48 E
ATOM δ76δ CA GLY 545 144, .g34 42, .606 22, .450 1.00 33, .48 E
ATOM δ769 C GLY 545 143, .557 42, .116 22, .844 1.00 33 .48 E
ATOM δ770 0 GLY 545 142, .546 42, .589 22. ,331 1.00 33, .48 E
ATOM δ771 N VAL 546 143, ,4g3 41, .159 23. .756 1.00 33, .48 E
ATOM δ772 CA VAL 546 142, ,186 40, .681 24. ,147 1.00 33, .48 E
ATOM 8773 CB VAL 546 142, ,26g 3g, .352 24. ,g43 1.00 33 .48 E
ATOM 8774 CGl VAL 546 140, ,884 38, .853 25. ,278 1.00 33, .48 E
ATOM 8775 CG2 VAL 546 142, ,g72 38, .309 24. ,112 1.00 33 .48 E
ATOM 8776 C VAL 546 141, ,4g7 41, .772 24. ,g53 1.00 33, .48 E
ATOM 8777 0 VAL 546 140, .299 42, .003 24. .774 1.00 33 .48 E
ATOM 8778 N LEU 547 142, ,251 42, .461 25. ,812 1.00 33, .48 E
ATOM 8779 CA LEU 547 141, .689 43, .548 26. ,61δ 1.00 33, .48 E
ATOM 8780 CB LEU 547 142. .733 44. .117 27. ,5g2 1.00 33, .48 E
ATOM 8781 CG LEU 547 142. .280 45. .196 28. ,5gg 1.00 33, .48 E
ATOM 87δ2 CDl LEU 547 143. .198 45. .168 29. ,7g3 1.00 33, .48 E
ATOM δ7δ3 CD2 LEU 547 142. .271 46. .581 27. ,g67 1.00 33, .48 E
ATOM δ784 C LEU 547 141, .155 44, .673 25. ,730 1.00 33, .48 E
ATOM 87δ5 0 LEU 547 140. .126 45. ,261 26. ,028 1.00 33, .48 E
ATOM 8786 N MET 548 141, ,δ56 44. ,983 24. ,647 1.00 33, .48 E
ATOM 87δ7 CA MET 548 141. ,3δ2 46. ,025 23. ,750 1.00 33, .48 E
ATOM 8788 CB MET 548 142. ,32δ 46. ,212 22. ,576 1.00 33, .48 E
ATOM 8789 CG MET 548 143. ,610 46. ,924 22. ,go6 1.00 33, .48 E
ATOM 8790 SD MET 548 144. ,50δ 47. ,202 21. ,3go 1.00 33, .48 E
ATOM 8791 CE MET 548 143. ,421 48. ,397 20. ,583 1.00 33, .48 E
ATOM 8792 C MET 548 140. ,042 45. ,580 23. ,225 1.00 33, .48 E
ATOM 8793 0 MET 548 139. ,092 46. ,346 23. ,178 1.00 33, .48 E
ATOM 8794 N TRP 54g 139. ,97g 44. ,321 22. ,824 1.00 33, .48 E ATOM δ7g5 CA TRP 549 138.,754 43.,747 22.,305 1.0033,.48 E
ATOM δ7g6 CB TRP 549 139. ,003 42. ,2g2 21. .878 1.00 33 .48 E
ATOM δ7g7 CG TRP 549 137. ,821 41. ,6δ2 21. ,198 1.00 33, .48 E
ATOM δ7g CD2 TRP 549 136. ,70δ 41. .054 21. ,δ34 1.00 33 .48 E
ATOM δ7g9 CE2 TRP 549 135. ,774 40. .746 20. ,δ34 1.00 33, .48 E
ATOM δ800 CE3 TRP 549 136. ,411 40, ,732 23. ,154 1.00 33, .48 E
ATOM 8δ01 CDl TRP 549 137. ,532 41, ,7ig 19. .869 1.00 33, .48 E
ATOM δδ02 NEl TRP 549 136. ,29g 41, ,160 19. ,639 1.00 33, .48 E
ATOM 8803 CZ2 TRP 549 134. ,566 40. ,134 21. .113 1.00 33, .48 E
ATOM 8804 CZ3 TRP 54g 135. ,220 40. ,131 23. ,431 1.00 33, .48 E
ATOM 8805 CH2 TRP 54g 134. ,306 3g. ,836 22. ,419 1.00 33, .48 E
ATOM 8δ06 C TRP 549 137. .691 43. ,7g5 23. ,402 1.00 33, .48 E
ATOM δ807 0 TRP 549 136, .533 44. .120 23. ,169 1.00 33, .48 E
ATOM 8δ08 N GLU 550 138, .112 43. ,467 24. ,609 1.00 33, .48 E
ATOM 8809 CA GLU 550 137, .231 43. .448 25. .753 1.00 33 .48 E
ATOM 8810 CB GLU 550 138, .018 42. ,g26 26. .951 1.00 33, .48 E
ATOM 8811 CG GLU 550 137, .185 42, .261 28. ,004 1.00 33, .48 E
ATOM 8812 CD GLU 550 138, .030 41, .473 28. .985 1.00 33 .48 E
ATOM 8813 OEl GLU 550 137, ,46δ 40. ,goδ 29. .956 1.00 33, .48 E
ATOM 8814 OE2 GLU 550 139, .263 41, .421 28. . 777 1.00 33 .48 E
ATOM 8δl5 C GLU 550 136, .632 44, .828 26. .060 1.00 33, .48 E
ATOM δδlδ 0 GLU 550 135, .619 44, .933 26, .760 1.00 33 .48 E
ATOM δδl7 N VAL 551 137, ,23δ 45, .890 25, .537 1.00 33, .48 E
ATOM δδl8 CA VAL 551 136, ,737 47, ,228 25, ,808 1.00 33, .48 E
ATOM 8819 CB VAL 551 137, .gog 48, .225 26. ,032 1.00 33, .48 E
ATOM 8δ20 CGl VAL 551 137. .371 4g, ,633 26. ,228 1.00 33, .48 E
ATOM 8821 CG2 VAL 551 138. .713 47, ,828 27, ,241 1.00 33, .48 E
ATOM 8δ22 C VAL 551 135. .843 47, ,749 24. ,686 1.00 33, .48 E
ATOM 8823 0 VAL 551 134. .762 48, ,278 24. ,930 1.00 33, .48 E
ATOM 8824 N PHE 552 136. ,2gg 47. ,599 23. ,451 1.00 33, .48 E
ATOM 8δ25 CA PHE 552 135, .538 4δ. .062 22. ,304 1.00 33, .48 E
ATOM δ826 CB PHE 552 136, ,3 6 47. .970 21. ,051 1.00 33, .48 E
ATOM 8δ27 CG PHE 552 137, ,280 4g. ,163 20. ,84δ 1.00 33, .48 E
ATOM 8828 CDl PHE 552 136, ,78δ 50. ,310 20. ,256 1.00 33, .48 E
ATOM 8δ29 CD2 PHE 552 138, ,5g6 4g. ,151 21. ,270 1.00 33, .48 E
ATOM δδ30 CEl PHE 552 137, ,5g2 51, ,412 20. ,090 1.00 33 .48 E
ATOM 8831 CE2 PHE 552 139, ,402 50, ,253 21. ,107 1.00 33, .48 E
ATOM 8δ32 CZ PHE 552 138, ,go2 51, .378 20. ,51δ 1.00 33 .48 E
ATOM δδ33 C PHE 552 134, ,250 47. .280 22. ,142 1.00 33, .48 E
ATOM 8834 0 PHE 552 133, ,3og 47, .732 21. ,492 1.00 33, .48 E
ATOM 8835 N SER 553 134. ,220 46. .101 22. ,743 1.00 33, .48 E
ATOM 8δ36 CA SER 553 133. ,050 45. ,240 22. ,713 1.00 33, .48 E
ATOM 8837 CB SER 553 133. ,45δ 43. ,798 22. ,936 1.00 33, .48 E
ATOM 8838 OG SER 553 134. ,034 43. ,667 24. ,216 1.00 33, .48 E ATOM δδ39 C SER 553 132.,191 45.,703 23.,876 1.0033,,48 E
ATOM δδ40 0 SER 553 131. ,016 45. ,352 23. ,999 1.00 33, .48 E
ATOM δδ4i N GLU 554 132. ,806 46. ,504 24. ,731 1.00 33, .48 E
ATOM 8842 CA GLU 554 132. ,139 47. ,053 25. ,891 1.00 33, .48 E
ATOM 8δ43 CB GLU 554 130. ,922 47. ,867 25. ,469 1.00 33, .48 E
ATOM δ844 CG GLU 554 131. ,298 49. .064 24. ,636 1.00 33, .48 E
ATOM 8845 CD GLU 554 130. ,190 50. .093 24. ,556 1.00 33, .48 E
ATOM 8846 OEl GLU 554 130. ,340 51. .085 23. ,796 1.00 33, .48 E
ATOM 8δ47 OE2 GLU 554 129. ,169 49. .906 25. ,263 1.00 33, .48 E
ATOM δδ48 C GLU 554 131. ,728 46, .036 26. ,g28 1.00 33 .48 E
ATOM 8δ49 0 GLU 554 130. ,570 46, .021 27. ,348 1.00 33, .48 E
ATOM δδ50 N GLY 555 132. ,669 45, .189 27. ,343 1.00 33, .48 E
ATOM 8851 CA GLY 555 132. ,357 44, ,211 28. ,371 1.00 33, .48 E
ATOM 8852 C GLY 555 132. ,077 42, .778 27. ,g6i 1.00 33 .48 E
ATOM 8853 0 GLY 555 132, ,265 41, .872 2δ. ,771 1.00 33, .48 E
ATOM 8δ54 N LYS 556 131. ,627 42, .562 26, ,728 1.00 33, .48 E
ATOM δδ55 CA LYS 556 131. ,334 41, .217 26. ,247 1.00 33, .48 E
ATOM 8856 CB LYS 556 131. ,029 41, .260 24. ,753 1.00 33, .48 E
ATOM 8δ57 CG LYS 556 129. ,734 41, .986 24, ,460 1.00 33, .48 E
ATOM δδ58 CD LYS 556 129. ,415 42, .100 22. ,g78 1.00 33, .48 E
ATOM 8859 CE LYS 556 128. ,001 42, .668 22. ,7g5 1.00 33, .48 E
ATOM 8δ60 NZ LYS 556 127, .587 42, .859 21. .373 1.00 33, .48 E
ATOM 8861 C LYS 556 132. .459 40, .226 26, ,526 1.00 33, .48 E
ATOM 8δ62 0 LYS 556 133. .645 40, .569 26, ,440 1.00 33, .48 E
ATOM 8863 N ILE 557 132. ,076 38. .994 26, ,867 1.00 33, .48 E
ATOM 8864 CA ILE 557 133. .037 37, .936 27, .176 1.00 33 .48 E
ATOM 8865 CB ILE 557 132, ,353 36, .749 27, .822 1.00 33 .48 E
ATOM 8866 CG2 ILE 557 133, .376 35, .717 2δ, .227 1.00 33 .48 E
ATOM 8867 CGl ILE 557 131. ,584 37, .204 29. ,04g 1.00 33, .48 E
ATOM 8868 CDl ILE 557 130. .777 36, .087 29, .665 1.00 33 .48 E
ATOM 8δ69 C ILE 557 133. .754 37, ,419 25, .g3 1.00 33 .48 E
ATOM δδ70 0 ILE 557 133. ,136 37, .232 24, . δg 1.00 33, .48 E
ATOM 8871 N PRO 558 135. ,069 37, .177 26, .045 1.00 33, .48 E
ATOM 8872 CD PRO 558 135. ,g30 37, .564 27, .170 1.00 33 .48 E
ATOM 8873 CA PRO 558 135. ,8δ0 36, .678 24, ,g37 1.00 33, .48 E
ATOM 8δ74 CB PRO 558 137. ,2gg 36, .815 25. ,465 1.00 33, .48 E
ATOM δ875 CG PRO 558 137. ,196 37, .907 26. ,468 1.00 33, .48 E
ATOM 8876 C PRO 558 135, .538 35, .231 24, ,606 1.00 33 .48 E
ATOM 8δ77 0 PRO 558 135. .524 34, .376 25. ,481 1.00 33 .48 E
ATOM 8878 N TYR 559 135. ,268 34, .955 23. ,33g 1.00 33, .48 E
ATOM 8879 CA TYR 559 134. ,928 33, .603 22. ,930 1.00 33, .48 E
ATOM δ880 CB TYR 559 136, ,114 32, .676 23, ,171 1.00 33 .48 E
ATOM δδδl CG TYR 559 137, ,421 33, .259 22, ,696 1.00 33 .48 E
ATOM δδδ2 CDl TYR 559 138. ,366 33, .727 23, ,602 1.00 33, .48 E ATOM 8δδ3 CEl TYR 559 139,.548 34,.274 23,.175 1.00 33.48 E
ATOM δδ84 CD2 TYR 559 137, ,708 33, .359 21. .347 1.00 33 .48 E
ATOM 8δδ5 CE2 TYR 559 138, ,δ96 33, .906 20. .916 1.00 33 .4δ E
ATOM 88δ6 CZ TYR 559 139, ,δ05 34, .361 21. .834 1.00 33 .48 E
ATOM δ887 OH TYR 559 140, ,g7δ 34, .924 21. .405 1.00 33, .48 E
ATOM 88δδ C TYR 559 133, .714 33, .145 23. .732 1.00 33 .48 E
ATOM δ889 0 TYR 559 133, ,555 31, .978 24. .065 1.00 33, .48 E
ATOM δδ90 N GLU 560 132, ,δ57 34, .106 24. .025 1.00 33 .48 E
ATOM δδgi CA GLU 560 131, ,632 33, .893 24. .776 1.00 33, .48 E
ATOM 88 2 CB GLU 560 130, .567 34, .895 24. .287 1.00 33, .48 E
ATOM 8 g3 CG GLU 560 129, .134 34, .575 24. ,722 1.00 33, .48 E
ATOM 88g4 CD GLU 560 128, .g37 34, .715 26. .216 1.00 33, .48 E
ATOM δδ s OEl GLU 560 129, ,74g 34, .129 26. .973 1.00 33, .48 E
ATOM 8δg6 OE2 GLU 560 127, .971 35, .411 26. .631 1.00 33, .48 E
ATOM δδg7 C GLU 560 131, ,056 32. ,480 24. .734 1.00 33, .48 E
ATOM δδgδ 0 GLU 560 130, .753 31, .896 25. .768 1.00 33, .48 E
ATOM δδgg N ASN 561 130, ,g24 31. .917 23. .544 1.00 33, .48 E
ATOM δgoo CA ASN 561 130, .311 30, .610 23, .444 1.00 33, .48 E
ATOM δgoi CB ASN 561 129, .216 30, .674 22, .374 1.00 33 .48 E
ATOM δ o2 CG ASN 561 127, ,go6 31, .267 22, .901 1.00 33, .48 E
ATOM go3 ODl ASN 561 127, .835 32, .447 23, .282 1.00 33, .48 E
ATOM δ o4 ND2 ASN 561 126, .856 30, .441 22, .922 1.00 33, .48 E
ATOM sgos C ASN 561 131, .184 29, .366 23, .227 1.00 33, .48 E
ATOM δgoε 0 ASN 561 130, .668 28, .294 22. ,886 1.00 33, .48 E
ATOM go7 N ARG 562 132, .491 29, .472 23. ,413 1.00 33, .48 E
ATOM sgos CA ARG 562 133, .313 28. .290 23. ,241 1.00 33, .48 E
ATOM δgog CB ARG 562 134, .353 28, ,521 22, ,159 1.00 33, .48 E
ATOM δgio CG ARG 562 133. .757 28. ,915 20. ,818 1.00 33, .48 E
ATOM 8911 CD ARG 562 134. .527 28. ,273 19. ,669 1.00 33, .48 E
ATOM 8912 NE ARG 562 133. .831 27. ,092 19. ,174 1.00 33, .48 E
ATOM δ913 CZ ARG 562 134. .429 25. ,948 18. ,844 1.00 33, .48 E
ATOM gi4 NHl ARG 562 135. ,753 25. ,81δ 18. ,956 1.00 33, .48 E
ATOM δ915 NH2 ARG 562 133. ,697 24. ,930 18. ,398 1.00 33, .48 E
ATOM δ916 C ARG 562 133, ,976 27. .900 24, ,550 1.00 33, .48 E
ATOM δgi7 0 ARG 562 133, ,716 28. ,503 25, ,582 1.00 33, .48 E
ATOM 8gi8 N SER 563 134, .834 26. ,δ 4 24, ,518 1.00 33, .48 E
ATOM δgig CA SER 563 135, .492 26. ,440 25, ,734 1.00 33, .48 E
ATOM 8g20 CB SER 563 135, .176 24. .971 25. ,982 1.00 33, .48 E
ATOM 8g21 OG SER 563 135, ,934 24. .158 25. ,097 1.00 33, .48 E
ATOM δg22 C SER 563 136, ,g93 26. ,574 25. ,637 1.00 33, .48 E
ATOM δ923 0 SER 563 137. ,544 26. ,602 24. ,541 1.00 33, .48 E
ATOM δ924 N ASN 564 137. ,656 26. ,625 26. ,785 1.00 33, .48 E
ATOM 8g25 CA ASN 564 139. ,105 26. ,730 26. ,804 1.00 33, ,48 E
ATOM 8926 CB ASN 564 139. ,654 26. ,327 2δ. ,171 1.00 33, .48 E ATOM δg27 CG ASN 564 139.,316 27.327 29.257 1.0033.,4δ E
ATOM 2δ ODl ASN 564 138. ,621 28.317 29. ,013 1.00 33. ,4δ E
ATOM δg2g ND2 ASN 564 139. ,810 27.073 30. 466 1.00 33. ,48 E
ATOM δ930 c ASN 564 139. ,733 25.851 25. ,731 1.00 33, ,48 E
ATOM δ931 0 ASN 564 140. ,607 26.2g3 25. 005 1.00 33. ,48 E
ATOM 8g32 N SER 565 139. ,290 24.60δ 25. ,616 1.00 33. .48 E
ATOM 8933 CA SER 565 139. ,859 23.727 24. ,601 1.00 33. ,48 E
ATOM 8934 CB SER 565 139. ,421 22.27g 24. ,831 1.00 33, .48 E
ATOM 8935 OG SER 565 140. ,127 21.706 25. ,920 1.00 33, .48 E
ATOM 8936 C SER 565 139. ,467 24.164 23. ,206 1.00 33, .48 E
ATOM 8937 0 SER 565 140. ,263 24.075 22. ,280 1.00 33, .48 E
ATOM 8938 N GLU 566 138. ,235 24.636 23. ,058 1.00 33, .48 E
ATOM 893g CA GLU 566 137. ,743 25.0gδ 21, ,764 1.00 33, .48 E
ATOM δg40 CB GLU 566 136. ,246 25.426 21. ,849 1.00 33, .48 E
ATOM δ941 CG GLU 566 135. ,345 24.226 21. .635 1.00 33, .4δ E
ATOM δ942 CD GLU 566 133. ,8δ0 24.516 21. .912 1.00 33, .48 E
ATOM δ 43 OEl GLU 566 133. .538 24.776 23. .087 1.00 33, .48 E
ATOM g44 OE2 GLU 566 133. ,063 24.4δ0 20. ,958 1.00 33, ,4δ E
ATOM δg45 C GLU 566 138. .516 26.332 21. ,307 1.00 33, ,4δ E
ATOM 8g46 0 GLU 566 138. .866 26.471 20. ,129 1.00 33, .48 E
ATOM 8g47 N VAL 567 138. .778 27.232 22, ,250 1.00 33, .48 E
ATOM g4δ CA VAL 567 139. .508 28.445 21. ,932 1.00 33, .48 E
ATOM δg4g CB VAL 567 139, .571 2g.3g6 23. .139 1.00 33, .48 E
ATOM gso CGl VAL 567 140, .127 30.741 22. .708 1.00 33, .48 E
ATOM δgsi CG2 VAL 567 138, .18δ 2g.561 23, .735 1.00 33, .48 E
ATOM 8g52 C VAL 567 140, .909 28.035 21, .517 1.00 33 .48 E
ATOM 8g53 0 VAL 567 141, .428 28.4g2 20, .502 1.00 33, .48 E
ATOM 8g54 N VAL 56δ 141, .517 27.151 22, .291 1.00 33 .48 E
ATOM 8955 CA VAL 568 142, .852 26.703 21, ,g57 1.00 33, .48 E
ATOM 8956 CB VAL 568 143, .326 25.593 22, ,86δ 1.00 33, .48 E
ATOM 8957 CGl VAL 568 144, .677 25.100 22, ,3δ3 1.00 33, .48 E
ATOM 8958 CG2 VAL 568 143, .413 26.095 24, ,2gg 1.00 33, .48 E
ATOM sgs C VAL 568 142, .873 26.172 20. .544 1.00 33, .48 E
ATOM 8g60 0 VAL 568 143, .851 26.347 19, ,δ20 1.00 33, .48 E
ATOM 8 61 N GLU 569 141, .785 25.523 20, .152 1.00 33, ,4δ E
ATOM 62 CA GLU 569 141, ,709 24.972 18, .813 1.00 33, .48 E
ATOM 63 CB GLU 569 140, .611 23.907 18, .717 1.00 33, .48 E
ATOM δ 64 CG GLU 569 141, .078 22.619 18, ,02g 1.00 33, .48 E
ATOM g65 CD GLU 569 142, .270 21.930 18, ,743 1.00 33, ,4δ E
ATOM δg66 OEl GLU 569 142, .083 21.410 19, .876 1.00 33, .48 E
ATOM δ967 OE2 GLU 569 143, .395 21.90g 18, .174 1.00 33 .48 E
ATOM δ96δ C GLU 569 141, ,47g 26.064 17, ,78δ 1.00 33, .48 E
ATOM δ βg 0 GLU 569 142, .ιg3 26.112 16, ,7 4 1.00 33 .48 E
ATOM δg70 N ASP 570 140, .505 26.g46 18, ,02g 1.00 33, .48 E ATOM δg7i CA ASP 570 140.215 2δ.056 17, ,102 1.00 33, ,48 E
ATOM 8972 CB ASP 570 139.088 2δ.945 17. ,638 1.00 33, ,48 E
ATOM 8973 CG ASP 570 137.765 2δ.220 17, ,732 1.00 33, .48 E
ATOM 8974 ODl ASP 570 136.729 28.872 18. ,013 1.00 33, .48 E
ATOM δ975 OD2 ASP 570 137.766 26.g89 17. ,529 1.00 33, .48 E
ATOM 8976 C ASP 570 141.443 2δ.943 16. ,861 1.00 33, .48 E
ATOM 8977 O ASP 570 141.805 2g.224 15. ,716 1.00 33, .48 E
ATOM 8978 N ILE 571 142.073 2g.377 17. ,951 1.00 33, .48 E
ATOM 8979 CA ILE 571 143.242 30.244 17. ,876 1.00 33, .48 E
ATOM δ9δ0 CB ILE 571 143.783 30.621 19. ,2δ6 1.00 33, .48 E
ATOM δg i CG2 ILE 571 145.240 31.031 19. ,204 1.00 33, .48 E
ATOM δgδ2 CGl ILE 571 142.951 31.758 19. ,δ70 1.00 33, .48 E
ATOM δ9δ3 CDl ILE 571 142.613 32.803 18. ,δ68 1.00 33, .48 E
ATOM δ984 C ILE 571 144.377 2g.635 17. ,og5 1.00 33, .48 E
ATOM 8gδ5 O ILE 571 145.209 30.353 16. ,544 1.00 33 .48 E
ATOM δ986 N SER 572 144.404 28.312 17. ,042 1.00 33, .48 E
ATOM 89δ7 CA SER 572 145.470 27.612 16. .351 1.00 33 .48 E
ATOM δδ CB SER 572 145.733 26.278 17. .030 1.00 33, .48 E
ATOM 8gδg OG SER 572 146.687 25.553 16, .277 1.00 33 .48 E
ATOM δ990 C SER 572 145.197 27.3gθ 14, ,87δ 1.00 33, .48 E
ATOM δggi O SER 572 146.120 27.175 14, ,og2 1.00 33, .48 E
ATOM 8g 2 N THR 573 143.919 27.430 14, .521 1.00 33, .48 E
ATOM 8gg3 CA THR 573 143.484 27.262 13, .144 1.00 33, .48 E
ATOM δg 4 CB THR 573 141.979 26.g51 13, .077 1.00 33, .48 E
ATOM 8g 5 OGl THR 573 141.638 26. oog 14, ,og4 1.00 33, .48 E
ATOM δggε CG2 THR 573 141.609 26.363 11, .718 1.00 33, .48 E
ATOM δgg7 C THR 573 143.723 28.606 12, .455 1.00 33, .48 E
ATOM 8gg8 O THR 573 143.717 28.707 11, .228 1.00 33 .48 E
ATOM δggg N GLY 574 143.906 2g.645 13, .264 1.00 33, .48 E
ATOM gooo CA GLY 574 144.155 30.g65 12, ,723 1.00 33, .48 E
ATOM gooi C GLY 574 143.048 31.976 12, ,g20 1.00 33 .48 E
ATOM goo2 O GLY 574 143.185 33.118 12, ,512 1.00 33, .48 E
ATOM goo3 N PHE 575 141.952 31.569 13, ,541 1.00 33 .48 E
ATOM goo4 CA PHE 575 140.848 32.486 13, ,768 1.00 33 .48 E
ATOM goos CB PHE 575 13g.564 31.69g 13, .914 1.00 33 .48 E
ATOM gooδ CG PHE 575 139.217 30.g27 12, ,6g4 1.00 33 .48 E
ATOM goo7 CDl PHE 575 138.531 31.52g 11, .652 1.00 33 .48 E
ATOM goos CD2 PHE 575 139.618 2g.612 12, ,55g 1.00 33 .48 E
ATOM goog CEl PHE 575 138.250 30.833 10, .498 1.00 33 .48 E
ATOM goio CE2 PHE 575 139.341 28.g07 11, .411 1.00 33 .48 E
ATOM 9011 CZ PHE 575 138.656 2g.516 10, ,377 1.00 33 .48 E
ATOM 9012 C PHE 575 141. OδO 33.364 14, .981 1.00 33 .48 E
ATOM 9013 0 PHE 575 141.934 33.085 15, .815 1.00 33 .48 E
ATOM 9014 N ARG 576 140.315 34.434 15, .086 1.00 33 .48 E ATOM 9015 CA ARG 576 140.499 35.351 16.192 1.0033.48 E
ATOM 9016 CB ARG 576 141. 410 36. 497 15. 763 1.00 33. ,48 E
ATOM 9017 CG ARG 576 142. 69δ 36. 047 15. 120 1.00 33. ,48 E
ATOM 901δ CD ARG 576 143. 657 35. 529 16. 156 1.00 33. ,48 E
ATOM 90ig NE ARG 576 144. 4δδ 34. ,464 15. 627 1.00 33. ,48 E
ATOM 9020 CZ ARG 576 145. 744 34. ,277 15. 977 1.00 33. ,48 E
ATOM 9021 NHl ARG 576 146. 294 35. ,090 16. ,847 1.00 33, ,48 E
ATOM 9022 NH2 ARG 576 146. 441 33. ,278 15. ,469 1.00 33, ,48 E
ATOM 9023 C ARG 576 139. ,180 35. ,922 16. ,618 1.00 33. .48 E
ATOM 9024 0 ARG 576 138. ,135 35. ,509 16. ,145 1.00 33. .48 E
ATOM 9025 N LEU 577 139. ,235 36. ,883 17. ,523 1.00 33, .48 E
ATOM 9026 CA LEU 577 13δ. 026 37. ,524 17. ,977 1.00 33, .48 E
ATOM 9027 CB LEU 577 138. ,346 38. ,442 19. ,146 1.00 33, .48 E
ATOM 902δ CG LEU 577 138. ,821 37. ,69g 20. ,389 1.00 33, ,48 E
ATOM 902g CDl LEU 577 139. ,535 38. ,655 21. ,305 1.00 33, .48 E
ATOM 9030 CD2 LEU 577 137. ,635 37. ,06δ 21. ,0δ9 1.00 33. .48 E
ATOM 9031 C LEU 577 137. ,524 38, .315 16. ,7δ0 1.00 33. .48 E
ATOM 9032 0 LEU 577 138. ,305 38, ,63δ 15. ,δ8g 1.00 33, .48 E
ATOM 9033 N TYR 57δ 136. ,227 38, .sgg 16. ,73g 1.00 33, .48 E
ATOM 9034 CA TYR 57δ 135, ,662 39, .355 15, ,633 1.00 33, .48 E
ATOM 9035 CB TYR 57δ 134, ,17g 39, .050 15, .481 1.00 33, .48 E
ATOM 9036 CG TYR 578 133. ,34g 39, .2g3 16. .722 1.00 33, .48 E
ATOM 9037 CDl TYR 578 133. ,200 40, .563 17. .246 1.00 33, .48 E
ATOM 903δ CEl TYR 578 132, .419 40, ,7δ9 18. .358 1.00 33, .48 E
ATOM 903g CD2 TYR 578 132, ,693 38, .25δ 17, .351 1.00 33 .48 E
ATOM 9040 CE2 TYR 578 131. .912 38, .476 18, .460 1.00 33 .48 E
ATOM 9041 CZ TYR 578 131, .777 39, .743 lδ, ,g57 1.00 33 .48 E
ATOM 9042 OH TYR 578 130, .988 39, .973 20, .055 1.00 33 .48 E
ATOM 9043 C TYR 578 135, .862 40, .δ4g 15, .843 1.00 33 .48 E
ATOM 9044 0 TYR 578 136, .ogo 41, .315 16, .959 1.00 33 .48 E
ATOM 9045 N LYS 57g 135, .77g 41 .605 14, .764 1.00 33 .48 E
ATOM 9046 CA LYS 579 135, .g63 43 .026 14, .876 1.00 33 .48 E
ATOM 9047 CB LYS 579 136, .312 43, .625 13, .515 1.00 33 .48 E
ATOM 904δ CG LYS 579 136, .225 45, .143 13, .4g5 1.00 33 .48 E
ATOM 904g CD LYS 579 136, ,5g7 45 .7ig 12, .149 1.00 33 .48 E
ATOM 9050 CE LYS 579 136, .150 47 .165 12, .026 1.00 33 .48 E
ATOM 9051 NZ LYS 579 134, .704 47 .26g 11, .711 1.00 33 .48 E
ATOM 9052 C LYS 579 134, .716 43 .64 15, .435 1.00 33 .48 E
ATOM 9053 0 LYS 579 133, .674 43 .76g 14 .776 1.00 33 .48 E
ATOM 9054 N PRO 580 134 .δ07 44 .183 16 .677 1.00 33 .48 E
ATOM 9055 CD PRO 580 135 .gδ2 44 .124 17 .555 1.00 33 .48 E
ATOM 9056 CA PRO 580 133 .6g6 44 .860 17 .343 1.00 33 .48 E
ATOM 9057 CB PRO 580 134 .269 45 .177 lδ .716 1.00 33 .48 E
ATOM 905δ CG PRO 580 135 .725 45 .265 lδ .463 1.00 33 .48 E ATOM 905g c PRO 580 133.,301 46.103 16.564 1.0033,.48 E
ATOM 9060 0 PRO 580 134. ,133 46.744 15.g47 1.00 33, .48 E
ATOM 9061 N ARG 581 132. ,024 46.444 16.5δ4 1.00 33, .48 E
ATOM 9062 CA ARG 581 131. ,571 47.606 15.δ40 1.00 33, .48 E
ATOM 9063 CB ARG 581 130. ,072 47.δl3 16.062 1.00 33, .48 E
ATOM 9064 CG ARG 581 129. ,246 46.757 15.34δ 1.00 33, .48 E
ATOM 9065 CD ARG 581 127. ,732 47.040 15.381 1.00 33, .48 E
ATOM 9066 NE ARG 581 126. ,931 45.970 14.750 1.00 33, .48 E
ATOM 9067 CZ ARG 581 127. ,162 45.455 13.537 1.00 33, .48 E
ATOM 906δ NHl ARG 581 128. ,181 45.δ92 12.7g3 1.00 33, .48 E
ATOM 9069 NH2 ARG 581 126. ,361 44.510 13.056 1.00 33, .48 E
ATOM 9070 C ARG 581 132. ,358 4δ.δ7g 16.156 1.00 33, .48 E
ATOM 9071 0 ARG 581 133. .019 4g.437 15.283 1.00 33, .48 E
ATOM 9072 N LEU 5δ2 132, ,298 4g.320 17.406 1.00 33, .48 E
ATOM 9073 CA LEU 5δ2 133. ,004 50.521 17.836 1.00 33, .48 E
ATOM 9074 CB LEU 582 132. ,778 50.752 19.331 1.00 33, .48 E
ATOM 9075 CG LEU 582 131, ,365 51.211 ig.653 1.00 33, .48 E
ATOM 9076 CDl LEU 5δ2 131, .314 51.886 21.007 1.00 33, .48 E
ATOM 9077 CD2 LEU 582 130. .gso 52.ιgo 18.591 1.00 33, .48 E
ATOM 907δ C LEU 582 134. ,503 50.539 17.543 1.00 33, .48 E
ATOM 9079 0 LEU 5δ2 135. .157 51.558 17.742 1.00 33, .48 E
ATOM 90δ0 N ALA 583 135. .066 49.42g 17.084 1.00 33, .48 E
ATOM 90δl CA ALA 583 136. .488 4g.435 16.777 1.00 33, .48 E
ATOM 90δ2 CB ALA 583 137, .118 48.133 17.164 1.00 33, .48 E
ATOM 9083 C ALA 583 136, .675 4g.6δl 15.2g3 1.00 33, .48 E
ATOM 9084 0 ALA 583 135. .961 4g.ll2 14.475 1.00 33, .48 E
ATOM 90δ5 N SER 584 137. ,629 50.545 14.g54 1.00 33, .48 E
ATOM 90δ6 CA SER 584 137. .939 50. 77 13.563 1.00 33, .48 E
ATOM goδ7 CB SER 5δ4 138, ,635 52.232 13.480 1.00 33, .48 E
ATOM goδδ OG SER 5δ4 139. ,917 52.17g 14.070 1.00 33, .48 E
ATOM oδg C SER 5δ4 138. ,856 4g.δ0δ 12.g73 1.00 33, .48 E
ATOM 9090 0 SER 5δ4 139. ,567 4g .116 13.6g8 1.00 33, .48 E
ATOM 9ogι N THR 585 138. ,δ36 4g.676 11.654 1.00 33, .48 E
ATOM gog2 CA THR 585 139. ,656 4δ.6δl ιo.gg4 1.00 33, .48 E
ATOM 9093 CB THR 585 139. .578 48.837 g.4δ5 1.00 33 .48 E
ATOM 90g4 OGl THR 585 140. .593 4g.745 g.050 1.00 33 .48 E
ATOM gog5 CG2 THR 585 138. .237 4g.3g8 g.og3 1.00 33, .48 E
ATOM g096 C THR 585 141, .100 48.δ52 11.420 1.00 33, .48 E
ATOM 90g7 0 THR 585 141, .851 47.δδ7 11.525 1.00 33, .48 E
ATOM 9098 N HIS 586 141. ,4δ7 50.0g6 11.665 1.00 33, .48 E
ATOM 9ogg CA HIS 586 142. ,δ44 50.3gθ 12.0δ0 1.00 33, .48 E
ATOM 9100 CB HIS 586 143. ,095 5i.δg6 12.013 1.00 33, .48 E
ATOM 9101 CG HIS 5δ6 144. .465 52.307 12.45δ 1.00 33, .48 E
ATOM 9102 CD2 HIS 5δ6 144. .913 53.465 i2.gg7 1.00 33, .48 E ATOM gi03 NDl HIS 5δ6 145.566 51.485 12.352 1.0033.,48 E
ATOM gi04 CEl HIS 586 146. 632 52. 115 12.δog 1.00 33. ,48 E
ATOM gios NE2 HIS 586 146. 262 53. 318 13. 207 1.00 33. ■ 48 E
ATOM gi06 C HIS 5δ6 143. 044 49. 867 13. 4δ3 1.00 33. .48 E
ATOM 9107 O HIS 5δ6 144. ,042 49. ,237 13. ,7δg 1.00 33. ,48 E
ATOM 910δ N VAL 5δ7 142. ,070 50. ,120 14. ,337 1.00 33. ,48 E
ATOM giog CA VAL 5δ7 142. ,144 49. ,658 15. ,702 1.00 33, .48 E
ATOM 9110 CB VAL 5δ7 140. 995 50. 239 16. 506 1.00 33. .48 E
ATOM 9111 CGl VAL 5δ7 140. ,919 49. ,5δ6 17. ,δ72 1.00 33, ,48 E
ATOM 9112 CG2 VAL 587 141. ,199 51. ,716 16. ,64g 1.00 33. .48 E
ATOM 9113 C VAL 587 142, ,082 48. ,138 15. ,721 1.00 33, .48 E
ATOM 9114 O VAL 5δ7 142. ,552 47. ,495 16. ,656 1.00 33, .48 E
ATOM 9115 N TYR 5δδ 141. ,511 47. ,571 14. ,664 1.00 33, .48 E
ATOM 9116 CA TYR 5δδ 141. ,371 46. ,127 14. ,53δ 1.00 33, .48 E
ATOM 9117 CB TYR 5δδ 140, .204 45. ,788 13. .sgs 1.00 33, .48 E
ATOM 9118 CG TYR 5δδ 139, ,807 44. ,333 13. ,631 1.00 33. ,48 E
ATOM 9119 CDl TYR 5δδ 139. ,757 43. ,646 14. ,δ31 1.00 33. .48 E
ATOM 9120 CEl TYR 588 139, ,437 42. ,313 14. .878 1.00 33. .48 E
ATOM 9121 CD2 TYR 58δ 139, .516 43. .641 12. ,470 1.00 33, .48 E
ATOM 9122 CE2 TYR 5δδ 139, .194 42. .302 12. ,507 1.00 33, .48 E
ATOM 9123 CZ TYR 5δδ 139, .157 41, .645 13, .716 1.00 33, .48 E
ATOM 9124 OH TYR 5δδ 13δ, .843 40, .310 13, .766 1.00 33 .48 E
ATOM gi25 C TYR 5δ8 142, .665 45, .4gg 14, .044 1.00 33 .48 E
ATOM gi26 O TYR 58δ 142, .956 44, .354 14. .363 1.00 33, .48 E
ATOM gi27 N GLN 5δ9 143, .430 46, .260 13. ,265 1.00 33, .48 E
ATOM gi28 CA GLN 5δg 144, .720 45, ,811 12. .743 1.00 33 .48 E
ATOM gi29 CB GLN 5 g 145, .250 46, .770 11. ,6δ6 1.00 33 .48 E
ATOM 9130 CG GLN 5δg 144, .737 46, .521 10, ,2gg 1.00 33 .48 E
ATOM 9131 CD GLN 5δg 145, .648 45, .637 g, .481 1.00 33 .48 E
ATOM 9132 OEl GLN 5δg 145, .315 45, .262 8, .372 1.00 33 .48 E
ATOM 9133 NE2 GLN 5δg 146 .804 45 .311 10, ,023 1.00 33 .48 E
ATOM 9134 C GLN 58g 145, .720 45, .777 13, .874 1.00 33, .48 E
ATOM 9135 O GLN 58g 146, .638 44, .g65 13, ,86g 1.00 33, .48 E
ATOM gi36 N ILE sgo 145, .553 46, .676 14, .837 1.00 33 .48 E
ATOM gi37 CA ILE sgo 146, .461 46, .731 15, .971 1.00 33 .48 E
ATOM gi3δ CB ILE sgo 146 .335 48 .075 16, .762 1.00 33 .48 E
ATOM 9139 CG2 ILE sgo 147 .39g 48 .167 17, .839 1.00 33 .48 E
ATOM 9140 CGl ILE sgo 146 .563 49 .252 15, .809 1.00 33 .48 E
ATOM 9141 CDl ILE sgo 146 .7o 50 .603 16 .491 1.00 33 .48 E
ATOM 9142 C ILE sgo 146 .152 45 .550 16, .862 1.00 33 .48 E
ATOM 9143 O ILE sgo 147 .062 44 .8δ2 17, .334 1.00 33 .48 E
ATOM 9144 N MET 591 144 .664 45 .2δ7 17, .073 1.00 33 .48 E
ATOM 9145 CA MET 591 144 .431 44 .156 17 .895 1.00 33 .48 E
ATOM 9146 CB MET 591 142 .go4 44 .032 17 .873 1.00 33 .48 E ATOM 9147 CG MET s i 142.,205 44.,635 19.,071 1.0033.,48 E
ATOM 9148 SD MET 591 140. ,475 45. ,043 18. ,766 1.00 33, .48 E
ATOM 9149 CE MET 591 139. ,945 43. ,620 18. ,026 1.00 33. .48 E
ATOM 9150 c MET 591 145. ,056 42. ,909 17. ,300 1.00 33. .48 E
ATOM 9151 0 MET 591 145. ,702 42. ,128 17. ,97g 1.00 33, .48 E
ATOM 9152 N ASN 592 144. ,87δ 42. ,756 16. ,003 1.00 33, .48 E
ATOM 9153 CA ASN 592 145. ,406 41. ,620 15. ,2g4 1.00 33, .48 E
ATOM 9154 CB ASN 592 144. .853 41. ,607 13. ,87δ 1.00 33, .48 E
ATOM 9155 CG ASN 592 143. ,567 40. ,854 13. , 779 1.00 33, .48 E
ATOM 9156 ODl ASN 592 143, .526 39. ,683 14. .091 1.00 33, .48 E
ATOM 9157 ND2 ASN 592 142, .512 41. ,515 13. ,349 1.00 33, .48 E
ATOM 9158 C ASN 592 146. .917 41. ,511 15, ,256 1.00 33, .48 E
ATOM 915g O ASN 592 147. ,453 40. ,417 15, ,06g 1.00 33, .48 E
ATOM gi60 N HIS 593 147, ,626 42. ,621 15, .414 1.00 33, .48 E
ATOM 9161 CA HIS 593 149, .074 42. .514 15, .381 1.00 33, .48 E
ATOM 9162 CB HIS 593 149, .735 43. .831 14, .982 1.00 33, .48 E
ATOM 9163 CG HIS 593 151, .156 43. ,671 14, .524 1.00 33, .48 E
ATOM 9164 CD2 HIS 593 151, .866 42. .561 14, .198 1.00 33 .48 E
ATOM 9165 NDl HIS 593 152, . oog 44, .741 14, ,328 1.00 33 .48 E
ATOM gi66 CEl HIS 593 153, .180 44, ,295 13, .900 1.00 33 .48 E
ATOM gi67 NE2 HIS 593 153, .119 42. ,976 13, .812 1.00 33 .48 E
ATOM gi68 C HIS 593 149, .519 42. ,0δ6 16, .759 1.00 33, .48 E
ATOM giεg O HIS 593 150, .611 41. ,572 16, .938 1.00 33, .48 E
ATOM gi70 N CYS 594 148, .645 42. ,282 17, .733 1.00 33, .48 E
ATOM 9171 CA CYS 594 148, .935 41, ,889 19, .103 1.00 33, .48 E
ATOM 9172 CB CYS 594 147, .96g 42, .561 20, .090 1.00 33 .48 E
ATOM 9173 SG CYS 594 148, .336 44, .250 20, .602 1.00 33 .48 E
ATOM gi74 C CYS 594 148, .763 40, .382 19, .213 1.00 33 .48 E
ATOM 9175 O CYS 594 149, .355 39, .742 20, .081 1.00 33 .48 E
ATOM 9176 N TRP 595 147, .947 39, .821 18, .329 1.00 33 .48 E
ATOM 9177 CA TRP 595 147, .675 38, .389 18, .349 1.00 33 .48 E
ATOM 917δ CB TRP 595 146, .190 38. .119 18, .080 1.00 33 .48 E
ATOM 9179 CG TRP 595 145, .255 38, .733 19, .066 1.00 33 .48 E
ATOM 9180 CD2 TRP 595 143 .9g3 39, ,339 lδ .783 1.00 33 .48 E
ATOM 9181 CE2 TRP 595 143 .436 39, ,732 20, .007 1.00 33 .48 E
ATOM 9182 CE3 TRP 595 143 .282 39, ,586 17, .612 1.00 33 .48 E
ATOM 9183 CDl TRP 595 145, .407 38, .783 20, .414 1.00 33 .48 E
ATOM 9184 NEl TRP 595 144, .317 39. .382 20, .991 1.00 33 .48 E
ATOM 9185 CZ2 TRP 595 142, .211 40. .354 20, .093 1.00 33 .48 E
ATOM gi86 CZ3 TRP 595 142, .06g 40, .201 17, ,69g 1.00 33 .48 E
ATOM gi87 CH2 TRP 595 141 .542 40, .580 18, .929 1.00 33 .48 E
ATOM giδδ C TRP 595 148, .504 37, ,523 17, .407 1.00 33 .48 E
ATOM gisg O TRP 595 148, .130 36, .404 17, .126 1.00 33 .48 E
ATOM gigo N LYS 596 149, .623 38, .024 16, .912 1.00 33 .48 E
Figure imgf000245_0001
ATOM 9191 CA LYS 596 150.45δ 37. ,210 16. ,038 1.00 33, ,48 E
ATOM 9192 CB LYS 596 151.718 37. ,97δ 15. ,654 1.00 33, .48 E
ATOM 9W3 CG LYS 596 151.485 39. ,070 14. 643 1.00 33, .48 E
ATOM ιg4 CD LYS 596 151.265 38. ,461 13. ,292 1.00 33, .48 E
ATOM 9195 CE LYS 596 150.785 39. ,4δ2 12. 289 1.00 33, .48 E
ATOM 9196 NZ LYS 596 150.582 38. ,825 10. 960 1.00 33, .48 E
ATOM 9197 C LYS 596 150.841 35. ,926 16. ,766 1.00 33, .48 E
ATOM 919δ O LYS 596 151.025 35. ,92δ 17. ,981 1.00 33, .48 E
ATOM 919g N GLU 597 150.962 34. .831 16. ,028 1.00 33, .48 E
ATOM g200 CA GLU 597 151.323 33. ,555 16. ,640 1.00 33, .48 E
ATOM g2oi CB GLU 597 151.226 32. .419 15. ,622 1.00 33, .48 E
ATOM g202 CG GLU 597 151.872 31. ,130 16. ,120 1.00 33. .48 E
ATOM 9203 CD GLU 597 151.095 29. ,881 15. ,729 1.00 33. .48 E
ATOM 9204 OEl GLU 597 150. sgg 29. ,669 14. ,501 1.00 33. .48 E
ATOM 9205 OE2 GLU 597 150.687 29. ,118 16. ,652 1.00 33. .48 E
ATOM 9206 C GLU 597 152.704 33. ,527 17. ,286 1.00 33. .48 E
ATOM 9207 O GLU 597 152.863 33. ,020 18. ,384 1.00 33. .48 E
ATOM 9208 N ARG 598 153.712 34. ,037 16. ,593 1.00 33. .48 E
ATOM 9209 CA ARG 598 155.055 34. ,072 17. ,159 1.00 33. .48 E
ATOM 9210 CB ARG 598 156.133 34. ,153 16. ,075 1.00 33, .48 E
ATOM 9211 CG ARG 598 156.46g 32, ,δ66 15. ,355 1.00 33, .48 E
ATOM 9212 CD ARG 598 157.606 33, .124 14. ,379 1.00 33 .48 E
ATOM 9213 NE ARG 598 158.2g5 31, .δ89 14. ,018 1.00 33 .48 E
ATOM 9214 CZ ARG 598 15δ.δg3 31, .077 14. ,892 1.00 33 .48 E
ATOM 9215 NHl ARG 598 i5δ.δgo 31, .366 16. ,192 1.00 33 .48 E
ATOM 9216 NH2 ARG 598 i5g.4g9 29, .971 14, ,467 1.00 33 .48 E
ATOM 9217 C ARG 598 155.145 35, .323 17, ,998 1.00 33 .48 E
ATOM 9218 O ARG 598 154.620 36, .368 17, ,622 1.00 33 .48 E
ATOM 92ig N PRO 599 155.821 35, .238 19, ,143 1.00 33 .48 E
ATOM g220 CD PRO 599 156.341 34, .033 19, ,802 1.00 33, .48 E
ATOM 9221 CA PRO 599 155.959 36, .396 20, ,017 1.00 33, .48 E
ATOM 9222 CB PRO 599 156.682 35, .819 21, ,227 1.00 33, .48 E
ATOM 9223 CG PRO 599 156.215 34, .397 21. ,245 1.00 33, .48 E
ATOM 9224 C PRO 59 156.742 37, .509 19. ,347 1.00 33, .48 E
ATOM 9225 0 PRO 5g9 156.400 38, .683 19. ,47g 1.00 33, .48 E
ATOM 9226 N GLU 600 157.781 37, .131 18. ,608 1.00 33 .48 E
ATOM 9227 CA GLU 600 158.629 38, ,100 17. ,g32 1.00 33 .48 E
ATOM 9228 CB GLU 600 159.886 37, .439 17. ,404 1.00 33 .48 E
ATOM 9229 CG GLU 600 159.681 36, ,596 16. ,178 1.00 33 .48 E
ATOM 9230 CD GLU 600 159.6δ2 35, ,138 16. ,528 1.00 33 .48 E
ATOM 9231 OEl GLU 600 159.870 34, .297 15. ,613 1.00 33 .48 E
ATOM 9232 OE2 GLU 600 159.494 34, .840 17. ,732 1.00 33 .48 E
ATOM 9233 C GLU 600 158.001 38, .861 16. ,781 1.00 33 .48 E
ATOM 9234 0 GLU 600 158.709 39, .501 16, .oog 1.00 33 .48 E
Figure imgf000246_0001
ATOM 9235 N ASP 601 156.690 38. .802 16, .634 1.00 33, .48 E
ATOM 9236 CA ASP 601 156.086 39. .534 15. .549 1.00 33, .48 E
ATOM 9237 CB ASP 601 155.467 38, .575 14. .544 1.00 33, .48 E
ATOM 9238 CG ASP 601 156.502 37, .692 13. .866 1.00 33, .48 E
ATOM g239 ODl ASP 601 157.700 38, .056 13. ,δ88 1.00 33, .48 E
ATOM 9240 OD2 ASP 601 156.113 36, .641 13. ,300 1.00 33, .48 E
ATOM 9241 C ASP 601 155.043 40, .479 16, ,083 1.00 33. .48 E
ATOM g242 o ASP 601 154.350 41, .142 15, ,322 1.00 33, .48 E
ATOM g243 N ARG 602 154.938 40, .543 17, ,402 1.00 33, .48 E
ATOM g244 CA ARG 602 153.966 41, .412 18, .032 1.00 33, .48 E
ATOM g245 CB ARG 602 153.348 40, .724 19, .248 1.00 33, .48 E
ATOM g246 CG ARG 602 152.58δ 39, ,455 18, .933 1.00 33, .48 E
ATOM g247 CD ARG 602 152.318 38, .668 20, .196 1.00 33, .48 E
ATOM g248 NE ARG 602 152.298 37, ,231 19, .954 1.00 33, .48 E
ATOM g24g CZ ARG 602 152.305 36, .324 20, .919 1.00 33, .48 E
ATOM g250 NHl ARG 602 152.32g 36, .706 22, ,180 1.00 33, .48 E
ATOM g251 NH2 ARG 602 152.300 35, .039 20, .628 1.00 33, .48 E
ATOM g252 C ARG 602 154.676 42, .673 18, .465 1.00 33, .48 E
ATOM g253 0 ARG 602 155.867 42, .642 18, .755 1.00 33, .48 E
ATOM g254 N PRO 603 153.955 43, .808 18, .506 1.00 33, .48 E
ATOM 9255 CD PRO 603 152.558 44, .033 18, .098 1.00 33, .48 E
ATOM 9256 CA PRO 603 154.574 45, .065 18, .916 1.00 33, .48 E
ATOM g257 CB PRO 603 153.551 46, .098 18, ,4g3 1.00 33, .48 E
ATOM g258 CG PRO 603 152.282 45, .378 18, .686 1.00 33, .48 E
ATOM g25g C PRO 603 154.803 45, .071 20, .407 1.00 33, .48 E
ATOM 260 O PRO 603 154.091 44, .390 21, .138 1.00 33, .48 E
ATOM g261 N ALA 604 155.815 45, .819 20, .844 1.00 33, .48 E
ATOM g262 CA ALA 604 156.140 45, .950 22, .255 1.00 33, .48 E
ATOM g263 CB ALA 604 157.543 46, .392 22, .411 1.00 33, .48 E
ATOM g264 C ALA 604 155.195 47, .022 22, .750 1.00 33, .48 E
ATOM g265 O ALA 604 154.644 47, .771 21, .951 1.00 33, ,48 E
ATOM g266 N PHE 605 154.984 47, .105 24, .051 1.00 33, .48 E
ATOM g267 CA PHE 605 154.068 48, .107 24, .552 1.00 33, .48 E
ATOM g268 CB PHE 605 153.908 47, .952 26, .055 1.00 33, .48 E
ATOM 26g CG PHE 605 153.015 46, .816 26, .450 1.00 33, .48 E
ATOM 9270 CDl PHE 605 151.689 46, .800 26, .067 1.00 33, .48 E
ATOM 9271 CD2 PHE 605 153.4 δ 45, .768 27, ,203 1.00 33, .48 E
ATOM 9272 CEl PHE 605 150.868 45, ,76δ 26, ,423 1.00 33, .48 E
ATOM 9273 CE2 PHE 605 152.678 44, .735 27, ,562 1.00 33, .48 E
ATOM 9274 CZ PHE 605 151.361 44, .737 27, ,171 1.00 33, .48 E
ATOM 9275 C PHE 605 154.52g 49. ,511 24. ,206 1.00 33, .48 E
ATOM 9276 O PHE 605 153.744 50. ,453 24. ,22g 1.00 33, .48 E
ATOM 9277 N SER 606 155.805 49. ,645 23. ,870 1.00 33, .48 E
ATOM 9278 CA SER 606 156.375 50. ,935 23. ,52g 1.00 33, .48 E ATOM 9279 CB SER 606 157,.890 50,.869 23..604 1.00 33,.48 E
ATOM 92δ0 OG SER 606 158, .405 49. .932 22. .681 1.00 33, .48 E
ATOM g2δl c SER 606 155, .961 51. ,359 22. ,140 1.00 33, .48 E
ATOM 92δ2 0 SER 606 155, .901 52. ,547 21. .843 1.00 33, .48 E
ATOM 92δ3 N ARG 607 155. .690 50. ,389 21. .276 1.00 33, .48 E
ATOM 92δ4 CA ARG 607 155. .257 50. ,712 19. .933 1.00 33, .48 E
ATOM 92δ5 CB ARG 607 155. .651 49. ,630 18. ,955 1.00 33, .48 E
ATOM 92δ6 CG ARG 607 154. .957 49. ,873 17, ,660 1.00 33 .48 E
ATOM 9287 CD ARG 607 155. .514 49. ,073 16, ,531 1.00 33 .48 E
ATOM 928δ NE ARG 607 155. .127 49. ,740 15, ,295 1.00 33 .48 E
ATOM 92δ9 CZ ARG 607 155. .972 50. ,151 14, ,356 1.00 33, .48 E
ATOM 9290 NHl ARG 607 157. .294 49. ,961 14, ,468 1.00 33, .48 E
ATOM 9291 NH2 ARG 607 155. ,487 50. ,806 13. ,321 1.00 33, .48 E
ATOM 92g2 C ARG 607 153. .745 50. ,925 19. ,841 1.00 33, .48 E
ATOM 9293 O ARG 607 153. .276 51. ,810 19. ,124 1.00 33, .48 E
ATOM 9294 N LEU 60δ 152. ,993 50. ,100 20. ,561 1.00 33, .48 E
ATOM 9295 CA LEU 60δ 151. , 542 50. ,191 20. ,594 1.00 33, .48 E
ATOM 92g6 CB LEU 608 150. ,971 49, ,041 21. ,430 1.00 33, .48 E
ATOM g2g7 CG LEU 608 151. ,075 47, ,649 20. .806 1.00 33, .48 E
ATOM g2gδ CDl LEU 608 150. ,765 46. ,595 21. .835 1.00 33, .48 E
ATOM g2gg CD2 LEU 608 150. 127 47. ,555 19. ,627 1.00 33, .48 E
ATOM g3oo C LEU 608 151. 132 51. ,522 21. ,203 1.00 33, .48 E
ATOM 30i O LEU 608 150. ,120 52. ,120 20. ,831 1.00 33, .48 E
ATOM g302 N LEU 6og 151. ,939 51, .972 22. ,154 1.00 33 .48 E
ATOM g303 CA LEU 6og 151. ,717 53, .232 22. .848 1.00 33, .48 E
ATOM g304 CB LEU 6og 152. ,766 53, .378 23. .945 1.00 33, .48 E
ATOM g305 CG LEU 6og 152. ,562 54, .543 24, .901 1.00 33, .48 E
ATOM g306 CDl LEU 609 151. ,083 54, .702 25, ,203 1.00 33, .48 E
ATOM g307 CD2 LEU 609 153. ,381 54, .311 26, ,162 1.00 33, .48 E
ATOM g308 C LEU 609 151. 782 54, .398 21, ,849 1.00 33, .48 E
ATOM g3og O LEU 609 150. 885 55, .236 21, ,δ04 1.00 33, .48 E
ATOM 9310 N ARG 610 152. 855 54. .452 21. ,061 1.00 33, .48 E
ATOM 9311 CA ARG 610 152. 988 55. .477 20. ,029 1.00 33, .48 E
ATOM 9312 CB ARG 610 154. ,180 55. ,204 19. ,109 1.00 33, .48 E
ATOM 9313 CG ARG 610 155. ,554 55. ,434 19. ,705 1.00 33, .48 E
ATOM 9314 CD ARG 610 156. ,605 54. ,512 19. ,059 1.00 33, .48 E
ATOM 9315 NE ARG 610 157. ,954 54, ,694 19. ,605 1.00 33, .48 E
ATOM 9316 CZ ARG 610 158. ,251 54. .899 20. ,δ94 1.00 33, .48 E
ATOM 9317 NHl ARG 610 157. ,291 54, ,960 21. ,δ23 1.00 33, .48 E
ATOM 931δ NH2 ARG 610 159. ,527 55, .045 21. ,258 1.00 33, .48 E
ATOM g3ig C ARG 610 151. ,752 55, .305 19. ,185 1.00 33, .48 E
ATOM g320 O ARG 610 150. ,886 56, .163 19. ,136 1.00 33, .48 E
ATOM g321 N GLN 611 151. ,713 54, .163 18. ,511 1.00 33, .48 E
ATOM g322 CA GLN 611 150. ,631 53, .767 17. ,627 1.00 33, .48 E ATOM 9323 CB GLN 611 150.682 52.263 17,.453 1.0033,.48 E
ATOM 324 CG GLN 611 14g.777 51.781 16. .397 1.00 33, ,48 E
ATOM g325 CD GLN 611 150.533 51.332 15. .185 1.00 33, .48 E
ATOM g326 OEl GLN 611 151.500 50.568 15. ,295 1.00 33, .48 E
ATOM 327 NE2 GLN 611 150.091 51.775 14, .013 1.00 33, .48 E
ATOM g32 C GLN 611 149.232 54.180 18. .100 1.00 33, .48 E
ATOM g32g O GLN 611 148.48δ 54.840 17. .370 1.00 33, .48 E
ATOM g330 N LEU 612 148. δ68 53.787 19, .316 1.00 33, .48 E
ATOM 9331 CA LEU 612 147.554 54.129 19, ,849 1.00 33, .48 E
ATOM 9332 CB LEU 612 147.281 53.353 21, ,144 1.00 33, .48 E
ATOM 9333 CG LEU 612 146.908 51.876 20, ,978 1.00 33 .48 E
ATOM 9334 CDl LEU 612 147.290 51.074 22, .212 1.00 33 .48 E
ATOM 9335 CD2 LEU 612 145.419 51.775 20, .699 1.00 33 .48 E
ATOM 9336 C LEU 612 147.439 55.618 20, .113 1.00 33 .48 E
ATOM 9337 O LEU 612 146.351 56.190 20, .033 1.00 33 .48 E
ATOM 9338 N ALA 613 148.570 56.243 20, .434 1.00 33 .48 E
ATOM 9339 CA ALA 613 148.60δ 57.673 20, .707 1.00 33 .48 E
ATOM 9340 CB ALA 613 149.960 5δ.061 21, .234 1.00 33 .48 E
ATOM 9341 C ALA 613 148.2δ2 58.446 19, .435 1.00 33, .48 E
ATOM 9342 O ALA 613 147.616 59.475 19, .496 1.00 33 .48 E
ATOM 9343 N GLU 614 148.742 57.95g lδ, .286 1.00 33 .48 E
ATOM 9344 CA GLU 614 148.427 58.628 17, .032 1.00 33, .48 E
ATOM 9345 CB GLU 614 148. gg7 57.888 15, .826 1.00 33, .48 E
ATOM 9346 CG GLU 614 150.504 57.g24 15, .700 1.00 33 .48 E
ATOM 9347 CD GLU 614 150.968 57.533 14, ,29g 1.00 33, .48 E
ATOM 934δ OEl GLU 614 150.682 56.381 13, .86δ 1.00 33, .48 E
ATOM 9349 OE2 GLU 614 151.610 58.3δ7 13, .629 1.00 33 .48 E
ATOM 9350 C GLU 614 146.924 58.672 16, ,δ64 1.00 33 .48 E
ATOM 9351 O GLU 614 146.312 5g.743 16, .863 1.00 33, .48 E
ATOM 9352 N ILE 615 146.335 57.487 16, .715 1.00 33 .48 E
ATOM 9353 CA ILE 615 144. δ9δ 57.345 16, .521 1.00 33 .48 E
ATOM 9354 CB ILE 615 144.446 55.920 16, .850 1.00 33 .48 E
ATOM 9355 CG2 ILE 615 142. g48 55.822 16, .753 1.00 33 .48 E
ATOM 9356 CGl ILE 615 145.113 54.937 15, ,δ88 1.00 33 .48 E
ATOM 9357 CDl ILE 615 144.846 53.483 16, .193 1.00 33, .48 E
ATOM 9358 C ILE 615 144.117 58.334 17, .369 1.00 33 .48 E
ATOM 9359 O ILE 615 143.054 58.791 16, .965 1.00 33 .48 E
ATOM g360 N ALA 616 144.654 58.672 18, ,53δ 1.00 33, .48 E
ATOM g361 CA ALA 616 143. ggε 59.6ig 19, .435 1.00 33, .48 E
ATOM g362 CB ALA 616 144.571 59.490 20, ,852 1.00 33, .48 E
ATOM g363 C ALA 616 144.159 61.05δ 18. ,943 1.00 33, .48 E
ATOM g364 O ALA 616 143.273 61.907 19. ,112 1.00 33, .48 E
ATOM g365 N GLU 617 145.304 61.334 18. ,341 1.00 33, .48 E
ATOM g366 CA GLU 617 145.582 62.664 17. ,847 1.00 33, .48 E ATOM g367 CB GLU 617 147.083 62.861 17..776 1.0033.48 E
ATOM g368 CG GLU 617 147.531 64.244 lδ, .120 1.00 33 .48 E
ATOM g36 CD GLU 617 148.912 64.226 18, .757 1.00 33 .48 E
ATOM g370 OEl GLU 617 149.104 63.411 19, .695 1.00 33 .48 E
ATOM g371 OE2 GLU 617 149.792 65.025 18, .329 1.00 33 .48 E
ATOM g372 C GLU 617 144.975 62.891 16, ,472 1.00 33 .48 E
ATOM 9373 0 GLU 617 145.313 63.876 15, ,816 1.00 33 .48 E
ATOM 9374 N SER 618 144.089 61.984 16, .044 1.00 33 .48 E
ATOM 9375 CA SER 618 143.422 62.106 14, .735 1.00 33 .48 E
ATOM g376 CB SER 618 144.405 61.842 13, ,59g 1.00 33 .48 E
ATOM g377 OG SER 618 143.706 61.947 12. .354 1.00 33 .48 E
ATOM g37δ C SER 618 142.220 61.183 14, .522 1.00 33, .48 E
ATOM g37g 0 SER 618 141. Oδδ 61.653 14, .425 1.00 33, .48 E
ATOM g3 o N GLY 619 142.490 59.8δ0 14, .400 1.00 33 .48 E
ATOM g3δi CA GLY 619 141.446 5δ.δδ3 14, .208 1.00 33 .48 E
ATOM g3δ2 C GLY 619 140.081 5g.317 13, .691 1.00 33 .48 E
ATOM g3δ3 0 GLY 619 139.761 5δ.g73 12, ,524 1.00 33 .48 E
ATOM g3δ4 OXT GLY 619 139.299 5g.g7δ 14, ,42g 1.00 33 .48 E
TER g3 5 GLY 619 E
ATOM g3 6 c GLY 354 16.563 go.δ73 25. .754 1.00 33, .48 F
ATOM g3δ7 0 GLY 354 16.539 91.577 24. ,74δ 1.00 33, .48 F
ATOM g3δδ N GLY 354 18.215 89.370 26. ,86g 1.00 33, .48 F
ATOM g3δg CA GLY 354 17.201 89.4g5 25. ,753 1.00 33, .48 F
ATOM g3 o N LYS 355 16.035 91.257 26. .910 1.00 33, .48 F
ATOM g3 ι CA LYS 355 15.414 92.561 27. ,085 1.00 33, .48 F
ATOM g3g2 CB LYS 355 14.329 92.481 28. ,160 1.00 33, .48 F
ATOM g3g3 CG LYS 355 14.854 91.995 29. ,503 1.00 33, .48 F
ATOM g3g4 CD LYS 355 13.809 92.144 30. ,5 9 1.00 33, .48 F
ATOM g3g5 CE LYS 355 12.527 91.352 30. .308 1.00 33, .48 F
ATOM 3gε NZ LYS 355 12.716 89.868 30. ,393 1.00 33, .48 F
ATOM 3g7 C LYS 355 16.485 93.554 27. ,540 1.00 33, .48 F
ATOM 939δ 0 LYS 355 16.173 g4.684 27. ,942 1.00 33, .48 F
ATOM 9399 N TRP 356 17.743 g3.125 27. ,480 1.00 33, .48 F
ATOM 9400 CA TRP 356 18.843 g3. 6i 27. ,919 1.00 33, .48 F
ATOM 9401 CB TRP 356 19.557 g3.334 29. ,100 1.00 33, .48 F
ATOM 9402 CG TRP 356 18.711 g3.163 30. ,295 1.00 33, .48 F
ATOM 9403 CD2 TRP 356 18.465 g4.141 31. ,304 1.00 33, .48 F
ATOM 9404 CE2 TRP 356 17.664 g3.536 32. ,282 1.00 33, .48 F
ATOM 9405 CE3 TRP 356 18.850 g5.472 31. ,475 1.00 33, .48 F
ATOM 9406 CDl TRP 356 18.055 g2.033 30. ,685 1.00 33, .48 F
ATOM 9407 NEl TRP 356 17.426 g2.248 31. ,881 1.00 33, ,48 F
ATOM 940δ CZ2 TRP 356 17.244 g4.212 33. 414 1.00 33. ,48 F
ATOM g4og CZ3 TRP 356 18.432 g6.138 32. 595 1.00 33. ,48 F
ATOM g4io CH2 TRP 356 17.638 95.511 33. 553 1.00 33. ,48 F ATOM 9411 c TRP 356 19.85δ g4.213 26.,δ39 1.00 33..48 F
ATOM 9412 0 TRP 356 20.797 4.gg2 27. .040 1.00 33. .48 F
ATOM 9413 N VAL 357 19.703 g3.546 25. .702 1.00 33. .48 F
ATOM 9414 CA VAL 357 20.640 g3.767 24. .618 1.00 33, .48 F
ATOM 9415 CB VAL 357 20.334 g2.δδg 23, ,426 1.00 33, .48 F
ATOM 9416 CGl VAL 357 21.174 g3.323 22, ,253 1.00 33, .48 F
ATOM g417 CG2 VAL 357 20.601 gi.452 23, .769 1.00 33, .48 F
ATOM g418 C VAL 357 20.534 95.210 24, .163 1.00 33, .48 F
ATOM 9419 O VAL 357 19.430 95.72δ 23, ,974 1.00 33, .48 F
ATOM 9420 N ILE 358 21.679 g5.864 24, .007 1.00 33, .48 F
ATOM 9421 CA ILE 358 21.706 97.246 23, .551 1.00 33, .48 F
ATOM 9422 CB ILE 358 22.331 98.226 24, .570 1.00 33, .48 F
ATOM 9423 CG2 ILE 358 22.246 99.628 24, .026 1.00 33, .48 F
ATOM 9424 CGl ILE 358 21.588 98.ig2 25, .907 1.00 33 .48 F
ATOM 9425 CDl ILE 358 21.938 gg.366 26, .823 1.00 33, .48 F
ATOM 9426 C ILE 358 22.561 97.333 22. .315 1.00 33, .48 F
ATOM 9427 O ILE 358 23.746 97.022 22, .361 1.00 33, .48 F
ATOM g428 N ASP 35g 21.951 g7.759 21, .216 1.00 33, .48 F
ATOM g42g CA ASP 35g 22.639 97.g37 19, .944 1.00 33, .48 F
ATOM g430 CB ASP 35g 21.624 g8.447 18, .922 1.00 33, .48 F
ATOM g431 CG ASP 359 22.262 gg.170 17, .757 1.00 33, .48 F
ATOM g432 ODl ASP 359 22.δ73 100.232 17, .979 1.00 33, .48 F
ATOM g433 OD2 ASP 359 22.141 gδ.6δ4 16, .611 1.00 33, .48 F
ATOM g434 C ASP 359 23.79δ gδ.g36 20, .134 1.00 33, .48 F
ATOM g435 O ASP 359 23.5δl 100.145 20, .272 1.00 33, .48 F
ATOM g436 N PRO 360 25.04g gδ.432 20, .152 1.00 33, .48 F
ATOM 9437 CD PRO 360 25.446 97.055 19, .811 1.00 33, .48 F
ATOM 9438 CA PRO 360 26.234 9g.277 20, .331 1.00 33, .48 F
ATOM 943g CB PRO 360 27.3gg gδ.303 20, .111 1.00 33, .48 F
ATOM g440 CG PRO 360 26.δl7 97.26δ 19, .225 1.00 33, .48 F
ATOM g441 C PRO 360 26.242 100.456 19, .376 1.00 33, .48 F
ATOM g442 O PRO 360 26.δl5 101.510 19, .667 1.00 33, .48 F
ATOM g443 N SER 361 25.594 100.274 18, .235 1.00 33, .48 F
ATOM g444 CA SER 361 25.497 101.338 17, .259 1.00 33, .48 F
ATOM 9445 CB SER 361 24.754 100.843 16, .032 1.00 33, .48 F
ATOM 9446 OG SER 361 24.103 101.930 15, .414 1.00 33, .48 F
ATOM 9447 C SER 361 24.726 102.4gδ 17, ,8δ3 1.00 33, .48 F
ATOM 9448 O SER 361 24.782 103.634 17, .413 1.00 33, .48 F
ATOM 9449 N GLU 362 23.996 102.192 18, ,945 1.00 33, .48 F
ATOM 9450 CA GLU 362 23.201 103. Iδ3 19, .641 1.00 33, .48 F
ATOM 9451 CB GLU 362 21.997 102.500 20, .310 1.00 33, .48 F
ATOM 9452 CG GLU 362 20.δ35 102.147 19, .356 1.00 33, .48 F
ATOM 9453 CD GLU 362 19.g5δ loo. ggo 19. ,δ67 1.00 33, .48 F
ATOM 9454 OEl GLU 362 ig.744 loo. δgo 21, .09g 1.00 33, .48 F ATOM 455 OE2 GLU 362 ig.473 100.189 19.031 1.00 33.,48 F
ATOM g456 c GLU 362 24. ogo 103.860 20.675 1.00 33, ,48 F
ATOM 9457 0 GLU 362 23.δ24 104.986 21.107 1.00 33, .48 F
ATOM 945δ N LEU 363 25.156 103.169 21.063 1.00 33, .48 F
ATOM 945g CA LEU 363 26. ogg 103.698 22.049 1.00 33, .48 F
ATOM g460 CB LEU 363 26.δ60102. 549 22.715 1.00 33, .48 F
ATOM g461 CG LEU 363 26.253 101.927 23.974 1.00 33, .48 F
ATOM g462 CDl LEU 363 27.063 100.705 24.423 1.00 33, .48 F
ATOM g463 CD2 LEU 363 26.215 102.988 25.072 1.00 33, .48 F
ATOM g464 C LEU 363 27.103 104.659 21.413 1.00 33, .48 F
ATOM 9465 0 LEU 363 27.500104.480 20.268 1.00 33, .48 F
ATOM 9466 N THR 364 27.501105.689 22.147 1.00 33, .48 F
ATOM 9467 CA THR 364 2δ.47g 106.626 21.627 1.00 33, .48 F
ATOM 9468 CB THR 364 27.δl0107.792 20.867 1.00 33, .48 F
ATOM 9469 OGl THR 364 2δ.l22 109.034 21.512 1.00 33, .48 F
ATOM 9470 CG2 THR 364 26.307 107.594 20.805 1.00 33, .48 F
ATOM 9471 C THR 364 2g.34δ 107.171 22.755 1.00 33, .48 F
ATOM 9472 0 THR 364 28.917 10δ .027 23.534 1.00 33, .48 F
ATOM 9473 N PHE 365 30.577 106.652 22.82δ 1.00 33, .48 F
ATOM 9474 CA PHE 365 31.566 107.031 23.δ43 1.00 33, .48 F
ATOM 9475 CB PHE 365 32.794 106.167 23.684 1.00 33, .48 F
ATOM 9476 CG PHE 365 32.533 104.730 23.919 1.00 33, .48 F
ATOM 9477 CDl PHE 365 33.050104.100 25.026 1.00 33, .48 F
ATOM 9478 CD2 PHE 365 31.758 104.004 23.031 1.00 33 .48 F
ATOM 947g CEl PHE 365 32.805 102.769 25.247 1.00 33 .48 F
ATOM g480 CE2 PHE 365 31.502 102.659 23.243 1.00 33 .48 F
ATOM g4δi CZ PHE 365 32.026 102.039 24.351 1.00 33 .48 F
ATOM g4δ2 C PHE 365 31.984 10δ .488 23.804 1.00 33, .48 F
ATOM g4δ3 0 PHE 365 32.23410g.034 22.738 1.00 33, .48 F
ATOM g44 N VAL 366 32.069 iog.124 24.964 1.00 33, .48 F
ATOM g4 5 CA VAL 366 32.46g no.5ig 24.g85 1.00 33, .48 F
ATOM g486 CB VAL 366 31.484 111.357 25.7δg 1.00 33, .48 F
ATOM 9487 CGl VAL 366 31.633 112.815 25.432 1.00 33, .48 F
ATOM 948δ CG2 VAL 366 30.077 110.886 25.509 1.00 33, .48 F
ATOM 4δg C VAL 366 33.877 110.6 2 25.555 1.00 33, .48 F
ATOM g4go 0 VAL 366 34.6δ0 111.462 25.021 1.00 33, .48 F
ATOM g4gι N GLN 367 34.1δ5 10g.961 26.622 1.00 33, .48 F
ATOM g4g2 CA GLN 367 35.500 110.046 27.241 1.00 33 .48 F
ATOM g4g3 CB GLN 367 35.714 111.439 27.832 1.00 33 .48 F
ATOM g44 CG GLN 367 35.899 111.419 29.331 1.00 33 .48 F
ATOM g4 5 CD GLN 367 36.020112.805 29.g21 1.00 33 .48 F
ATOM g4gε OEl GLN 367 35.140113.651 2g.741 1.00 33 .48 F
ATOM 9497 NE2 GLN 367 37.113 113.048 30.638 1.00 33 .48 F
ATOM 949δ C GLN 367 35.659 iog. Oil 28.348 1.00 33 .48 F ATOM 949 O GLN 367 34.665 108.,548 28.,g2i 1.00 33.48 F
ATOM gsoo N GLU 368 36.914 108. ,658 28. ,644 1.00 33 .48 F
ATOM gsoi CA GLU 368 37.235 107. ,682 2g. ,6 8 1.00 33 .48 F
ATOM 9502 CB GLU 368 38.565 106. ,983 2g. ,4og 1.00 33 .48 F
ATOM 9503 CG GLU 368 38.502 105. ,827 28. ,426 1.00 33 .48 F
ATOM 9504 CD GLU 368 3g.84g 105. ,119 28. ,273 1.00 33 .48 F
ATOM 9505 OEl GLU 368 40.507 104, ,850 2g. ,317 1.00 33 .48 F
ATOM 9506 OE2 GLU 368 40.236 104, ,830 27. ,110 1.00 33 .48 F
ATOM 9507 C GLU 368 37.371 108, ,432 31. ,008 1.00 33 .48 F
ATOM 9508 O GLU 368 37.748 109, ,607 31. ,001 1.00 33 .48 F
ATOM 9509 N ILE 369 37.068 107, , 777 32. ,126 1.00 33 .48 F
ATOM 9510 CA ILE 369 37.201 108, ,452 33, ,415 1.00 33 .48 F
ATOM 9511 CB ILE 369 35.932 109, ,26g 33, , 777 1.00 33 .48 F
ATOM 9512 CG2 ILE 369 35.710 110, .361 32, ,757 1.00 33 .48 F
ATOM 9513 CGl ILE 369 34.697 108, .377 33. ,7g9 1.00 33 .48 F
ATOM 9514 CDl ILE 369 33.438 109, .144 34. ,093 1.00 33 .48 F
ATOM 9515 C ILE 369 37.519 107, .516 34. .569 1.00 33 .48 F
ATOM 9516 O ILE 369 37.588 107, ,g45 35. .719 1.00 33 .48 F
ATOM 9517 N GLY 370 37.718 106, .241 34. .258 1.00 33, .48 F
ATOM 9518 CA GLY 370 38.026 105, .268 35. .289 1.00 33. .48 F
ATOM 9519 C GLY 370 38.555 104, .001 34. .650 1.00 33. .48 F
ATOM 9520 O GLY 370 37.844 103, .324 33, .911 1.00 33. .48 F
ATOM 9521 N SER 371 3g.806 103, .663 34, ,g34 1.00 33. .48 F
ATOM 9522 CA SER 371 40.3g2 102, .476 34. .323 1.00 33. .48 F
ATOM 9523 CB SER 371 41.485 102, ,go4 33. .335 1.00 33. .48 F
ATOM g524 OG SER 371 40.g50 103, .78g 32. .350 1.00 33. .48 F
ATOM 9525 C SER 371 40.g43 101, .456 35. .320 1.00 33. .48 F
ATOM 9526 0 SER 371 40.735 101, .583 36. .544 1.00 33. , 48 F
ATOM g527 N GLY 372 41.618 100, .436 34. ,780 1.00 33. ,48 F
ATOM g528 CA GLY 372 42.188 gg, .387 35, ,613 1.00 33. , 48 F
ATOM g52 C GLY 372 41.858 7, .941 35, .241 1.00 33. ,48 F
ATOM g530 0 GLY 372 41.965 g7, .540 34, .072 1.00 33. 48 F
ATOM 531 N GLN 373 41.450 g7, .173 36, ,25g 1.00 33. 48 F
ATOM g532 CA GLN 373 41.117 gs, .738 36, .155 1.00 33. 48 F
ATOM 9533 CB GLN 373 40.084 95, .355 37, .226 1.00 33. 48 F
ATOM 9534 CG GLN 373 40.242 93, .940 37, .797 1.00 33. 48 F
ATOM 9535 CD GLN 373 39.819 92, .849 36. .825 1.00 33. 48 F
ATOM 9536 OEl GLN 373 40.386 92, .710 35. ,731 1.00 33. 48 F
ATOM 9537 NE2 GLN 373 38.812 92, .060 37. ,223 1.00 33. 48 F
ATOM 9538 C GLN 373 40.621 95, .263 34, ,79g 1.00 33. 48 F
ATOM 9539 0 GLN 373 41.305 95, .412 33, ,785 1.00 33. 48 F
ATOM 9540 N PHE 374 39.433 94, .669 34. ,7gι 1.00 33. 48 F
ATOM 9541 CA PHE 374 38.851 94, .175 33. ,548 1.00 33. 48 F
ATOM g542 CB PHE 374 37.617 93, .308 33. ,842 1.00 33. 48 F ATOM g543 CG PHE 374 36.606 93.972 34,,743 l.OO 33,.48 F
ATOM g544 CDl PHE 374 36.084 95.223 34. ,425 l.OO 33, .48 F
ATOM g545 CD2 PHE 374 36.179 93.340 35. ,903 l.OO 33, .48 F
ATOM g546 CEl PHE 374 35.150 95.83g 35. ,246 l.OO 33, .48 F
ATOM g547 CE2 PHE 374 35.247 3.g36 36. ,738 l.OO 33, .48 F
ATOM 954δ CZ PHE 374 34.724 95.196 36, ,413 1.00 33, .48 F
ATOM 954g C PHE 374 38.461 95.359 32. ,656 1.00 33, .48 F
ATOM gsso 0 PHE 374 37.361 95.414 32. ,104 1.00 33, .48 F
ATOM gssi N GLY 375 3g.360 96.324 32. ,53δ l.OO 33, .48 F
ATOM g552 CA GLY 375 3g.061 97.457 31. ,697 l.OO 33, .48 F
ATOM 9553 C GLY 375 38.g21 98.801 32. .382 l.OO 33, .48 F
ATOM 9554 0 GLY 375 39.715 9g.l87 33. ,252 l.OO 33 .48 F
ATOM 9555 N LEU 376 37.876 g9.513 31. ,985 l.OO 33 .48 F
ATOM 9556 CA LEU 376 37.638 100. 44 32. ,492 l.OO 33 .48 F
ATOM 9557 CB LEU 376 38.440 101.830 31, .638 l.OO 33 .48 F
ATOM 955δ CG LEU 376 39.135 101.171 30. .429 l.OO 33, .48 F
ATOM gssg CDl LEU 376 38.117 100.428 29. ,5δ2 l.OO 33, .48 F
ATOM g560 CD2 LEU 376 39.835 102.221 29, .581 1.00 33 .48 F
ATOM g561 C LEU 376 36.148 101.181 32. .447 l.OO 33 .48 F
ATOM g562 0 LEU 376 35.296 100.286 32. .332 l.OO 33, .48 F
ATOM g563 N VAL 377 35.δ48 102.476 32, .539 l.OO 33, .48 F
ATOM g564 CA VAL 377 34.476 102.961 32, ,523 1.00 33, .48 F
ATOM g565 CB VAL 377 33.876 103.034 33. ,968 l.OO 33, .48 F
ATOM g566 CGl VAL 377 33.95δ 101.668 34. ,643 l.OO 33, .48 F
ATOM g567 CG2 VAL 377 34.611 104.061 34. ,δ03 1.00 33, .48 F
ATOM g568 C VAL 377 34.441 104.349 31. .891 1.00 33, .48 F
ATOM 9569 0 VAL 377 35.157 105.265 32. ,331 1.00 33, .48 F
ATOM 9570 N HIS 378 33.622 104.503 30. ,δ47 l.OO 33, .48 F
ATOM g571 CA HIS 378 33.510 105.793 30. ,166 l.OO 33, .48 F
ATOM g572 CB HIS 378 33.517 105.63g 28. ,64g l.OO 33, .48 F
ATOM g573 CG HIS 378 34.651 104.837 28. .109 1.00 33, .48 F
ATOM 9574 CD2 HIS 378 35.6g6 105.196 27. ,325 1.00 33, .48 F
ATOM 9575 NDl HIS 378 34.736 103.468 28. ,267 1.00 33, .48 F
ATOM 9576 CEl HIS 378 35.7δ2 103.017 27. ,596 1.00 33, .48 F
ATOM 9577 NE2 HIS 378 36.3δl 104.045 27. ,016 1.00 33, .48 F
ATOM 9578 C HIS 378 32.223 106.536 30. ,506 l.OO 33, .48 F
ATOM 9579 0 HIS 378 31.329 106.006 31. ,154 1.00 33, .48 F
ATOM 9580 N LEU 379 32.155 107.775 30. ,036 1.00 33, .48 F
ATOM 9581 CA LEU 379 30.988 108.617 30. ,196 1.00 33, .48 F
ATOM 9582 CB LEU 379 31.372 109.981 30. ,756 l.OO 33, .48 F
ATOM 9583 CG LEU 379 30.463 111.092 30. ,224 1.00 33, .48 F
ATOM 9584 CDl LEU 379 29.019 110.698 30. 471 1.00 33, .48 F
ATOM 9585 CD2 LEU 379 30.787 112.422 30. ,881 1.00 33. .48 F
ATOM 9586 C LEU 379 30.459 10δ.7δ6 28. ,776 1.00 33. .48 F ATOM 5δ7 O LEU 379 30.945 109.635 2δ.031 1.00 33.48 F
ATOM 588 N GLY 380 29.476 107. g68 2δ.403 1.00 33.48 F
ATOM 95δ9 CA GLY 380 28.913 108.045 27.063 1.00 33.48 F
ATOM 9590 C GLY 380 27.43g 108.417 27.003 1.00 33.48 F
ATOM 95gi O GLY 380 26.87g 108. gso 27.g72 1.00 33.48 F
ATOM g5g2 N TYR 381 26.δ24 108.133 25.δ51 1.00 33.48 F
ATOM g5g3 CA TYR 381 25.411108.414 25.586 1.00 33.48 F
ATOM 5g4 CB TYR 381 25.243 109.599 24.631 1.00 33.48 F
ATOM gsgs CG TYR 381 25.δ6g 110.889 25.078 1.00 33.48 F
ATOM g5g6 CDl TYR 381 25.407 111.563 26.ig6 1.00 33.48 F
ATOM g5g7 CEl TYR 381 25.g64 112.786 26.583 1.00 33.48 F
ATOM 959δ CD2 TYR 381 26.g08 111.457 24.353 1.00 33.48 F
ATOM g5g9 CE2 TYR 381 27.475 112.670 24.726 1.00 33.48 F
ATOM 9600 CZ TYR 381 27.000 113.334 25.840 1.00 33.48 F
ATOM 9601 OH TYR 381 27.55g 114.546 26.ιgo 1.00 33.48 F
ATOM 9602 C TYR 381 24.744 107.216 24,g26 1.00 33.48 F
ATOM 9603 O TYR 381 25.37g 106.452 24.187 1.00 33.48 F
ATOM 9604 N TRP 382 23.445 107.0δ4 25.17g 1.00 33.48 F
ATOM 9605 CA TRP 382 22.642 106.018 24.611 1.00 33.48 F
ATOM 9606 CB TRP 382 22.405 104.943 25.661 1.00 33.48 F
ATOM 9607 CG TRP 382 21.612 103.810 25.166 1.00 33.48 F
ATOM 960δ CD2 TRP 382 20.634 103.066 25.8gg 1.00 33.4δ F
ATOM g609 CE2 TRP 382 20.143 102.069 25.040 1.00 33.4δ F
ATOM 9610 CE3 TRP 382 20.127 103.147 27.ιgg 1.00 33.4δ F
ATOM 9611 CDl TRP 382 21.677 103.250 23.g2g 1.00 33.4δ F
ATOM g612 NEl TRP 382 20.7g7 102.203 23.δ41 1.00 33.4δ F
ATOM g613 CZ2 TRP 382 19.171101.160 25.43δ 1.00 33.4δ F
ATOM g614 CZ3 TRP 382 19.171102.251 27.5δ9 1.00 33.4δ F
ATOM gei5 CH2 TRP 3δ2 18.69g 101.267 26.713 1.00 33.48 F
ATOM g616 C TRP 3δ2 21.326106.643 24.167 1.00 33.48 F
ATOM 9617 0 TRP 3δ2 20.758 107.447 24.904 1.00 33.48 F
ATOM 961δ N LEU 383 20.872 106.294 22.959 1.00 33.48 F
ATOM 96ig CA LEU 383 ιg.62g 106.805 22.355 1.00 33.48 F
ATOM g620 CB LEU 383 18.422 106.158 23.034 1.00 33.48 F
ATOM g621 CG LEU 383 lδ.4g2 104.631 22.903 1.00 33.48 F
ATOM g622 CDl LEU 383 17.225 103.956 23.398 1.00 33.48 F
ATOM g623 CD2 LEU 383 18.716 104.2 2 21.444 1.00 33.48 F
ATOM g624 C LEU 383 ιg.45g lθδ.333 22.311 1.00 33.48 F
ATOM 625 0 LEU 383 18.91410δ.δ79 21.361 1.00 33.48 F
ATOM g626 N ASN 384 ιg.g32 109.019 23.335 1.00 33.48 F
ATOM 627 CA ASN 384 19.843 110.468 23.406 1.00 33.48 F
ATOM 9628 CB ASN 384 18.637 110.886 24.242 1.00 33.48 F
ATOM 9629 CG ASN 384 18.422 109.974 25.422 1.00 33.48 F
ATOM 9630 ODl ASN 384 17.936108. δ49 25.268 1.00 33.48 F ATOM 9631 ND2 ASN 384 lδ.δio 110.433 26.610 1.0033,.48 F
ATOM 9632 C ASN 384 21.135 110.94g 24.061 1.00 33 .48 F
ATOM 9633 O ASN 384 22.143 110.243 24.009 1.00 33, .48 F
ATOM 9634 N LYS 385 21.110 112.119 24.6gg 1.00 33, .48 F
ATOM 9635 CA LYS 385 22.315 112.649 25.321 1.00 33, .48 F
ATOM g636 CB LYS 385 22.604 114.019 24.731 1.00 33, .48 F
ATOM g637 CG LYS 385 22.435 114.014 23.237 1.00 33, .48 F
ATOM g638 CD LYS 385 23.333 115.026 22.553 1.00 33, .48 F
ATOM 9639 CE LYS 385 24.776 114.569 22.568 1.00 33, .48 F
ATOM 9640 NZ LYS 385 25.317 114.527 23.g51 1.00 33, .48 F
ATOM 9641 C LYS 385 22.363 112.708 26.δ56 1.00 33, .48 F
ATOM 9642 O LYS 385 23.073 113.534 27.433 1.00 33, ,48 F
ATOM 9643 N ASP 3δ6 21.617 111.831 27.51δ 1.00 33, .48 F
ATOM 9644 CA ASP 3δ6 21.639 111.784 2δ.g75 1.00 33, .48 F
ATOM 9645 CB ASP 3δ6 20.462 110.976 2g.515 1.00 33, .48 F
ATOM 9646 CG ASP 3δ6 19.108 111.602 2g.216 1.00 33, .48 F
ATOM 9647 ODl ASP 3δ6 18.126 110.835 2g.251 1.00 33, .48 F
ATOM 9648 OD2 ASP 386 19.013 112.828 2δ.g69 1.00 33, .48 F
ATOM g64 C ASP 386 22.915 111.023 29.2δ7 1.00 33, .48 F
ATOM g650 O ASP 3δ6 23.099 iog. goδ 28.805 1.00 33, .48 F
ATOM 651 N LYS 3δ7 23.797 111.610 30.082 1.00 33, .48 F
ATOM g652 CA LYS 3δ7 25.058 110.951 30.418 1.00 33, .48 F
ATOM 9653 CB LYS 387 25.817 111.747 31.492 1.00 33, .48 F
ATOM 9654 CG LYS 387 26.465 113.043 30.985 1.00 33. .48 F
ATOM 9655 CD LYS 387 27.037 113.926 32.104 1.00 33. .48 F
ATOM 9656 CE LYS 3δ7 25.94δ 114.637 32.914 1.00 33. ,48 F
ATOM 9657 NZ LYS 3δ7 26.511115.569 33.g51 1.00 33. ,48 F
ATOM 9658 C LYS 387 24.7g6 109.556 30.g30 1.00 33. ,48 F
ATOM g65 0 LYS 387 23.7g6 109.30δ 31.590 1.00 33. ,48 F
ATOM 9660 N VAL 3δ8 25.685 108.636 30.5g7 1.00 33. .48 F
ATOM 9661 CA VAL 388 25.578 107.268 31.077 1.00 33. .48 F
ATOM 9662 CB VAL 3δ8 24.905 106.336 30.063 1.00 33, .48 F
ATOM 9663 CGl VAL 388 23.557 106.901 2g.66 1.00 33, .48 F
ATOM 9664 CG2 VAL 388 25.798 106.147 28.855 1.00 33, .48 F
ATOM 9665 C VAL 388 27.011 106. δ22 31.290 1.00 33, .48 F
ATOM g666 O VAL 388 27.94g 107.479 30.821 1.00 33, .48 F
ATOM g667 N ALA 389 27.17g 105.718 32.002 1.00 33, ,48 F
ATOM g668 CA ALA 389 28.4g8 105.201 32.2g2 1.00 33, ,48 F
ATOM gεεg CB ALA 389 2δ.666 105.073 33.785 1.00 33, ,48 F
ATOM g670 C ALA 389 2δ.6g5 103. δ4g 31.632 1.00 33, ,48 F
ATOM g671 O ALA 389 27.gδ5 102.898 31.938 1.00 33, ,48 F
ATOM g672 N ILE 390 29.657 103.753 30.724 1.00 33, ,48 F
ATOM 9673 CA ILE 390 29.907 102.474 30.065 1.00 33, ,48 F
ATOM 9674 CB ILE 390 30.021 102.662 28.566 1.00 33, ,48 F ATOM g675 CG2 ILE 3go 29.g30101.299 27,.875 1.00 33,.48 F
ATOM g676 CGl ILE 3 o 28.g07 103.614 28, .109 1.00 33, .48 F
ATOM g677 CDl ILE 3go 2g.l37 104.278 26, .777 1.00 33 .48 F
ATOM g678 C ILE 3go 31.172 101.812 30, .611 1.00 33 .48 F
ATOM 67g 0 ILE 3go 32.2g3 102.221 30 .331 1.00 33 .48 F
ATOM gεδo N LYS 391 30.g70 100.779 31, .406 1.00 33 .48 F
ATOM 96δl CA LYS 391 32.049 100.058 32 .038 1.00 33 .48 F
ATOM 96δ2 CB LYS 391 31.641 99.783 33, .490 1.00 33 .48 ■ F
ATOM g6δ3 CG LYS 391 32.26δ 98.627 34, .255 1.00 33, .48 F
ATOM g684 CD LYS 391 31.696 9δ.736 35, .683 1.00 33 .48 F
ATOM g685 CE LYS 391 31.600 97.410 36, .437 1.00 33, .48 F
ATOM g6δ6 NZ LYS 391 30.673 97.559 37, .634 1.00 33 .48 F
ATOM g687 C LYS 391 32.345 9δ.7δ3 31. .274 1.00 33, .48 F
ATOM g68δ 0 LYS 391 31.659 97.76g 31, .433 1.00 33 .48 F
ATOM g68g N THR 392 33.366 gδ.δ72 30, .422 1.00 33, .48 F
ATOM g690 CA THR 392 33.821 g7.741 29, .617 1.00 33 .48 F
ATOM 96gi CB THR 392 34.160 9δ.l76 28, .179 1.00 33, .48 F
ATOM g6g2 OGl THR 392 34.930 97.156 27, .540 1.00 33 .48 F
ATOM g6g3 CG2 THR 392 34.958 99.470 28, .187 1.00 33, .48 F
ATOM gβg4 C THR 392 35.075 97.14g 30, .270 1.00 33 .48 F
ATOM g6g5 0 THR 392 36.142 97.095 29, .668 1.00 33 .48 F
ATOM gβgε N GLU 405 27.689 85.276 33, .902 1.00 33 .48 F
ATOM g697 CA GLU 405 26.321 85.708 34, .166 1.00 33 .48 F
ATOM 96g8 CB GLU 405 25.506 84.566 34, .7g2 1.00 33, .48 F
ATOM 969g CG GLU 405 23.999 84.δl6 34, .821 1.00 33 .48 F
ATOM g θo CD GLU 405 23.220 δ3.743 35, ,5g3 1.00 33, .48 F
ATOM g70i OEl GLU 405 23.167 δ2.569 35, .130 1.00 33, .48 F
ATOM g702 OE2 GLU 405 22.664 84.0δ3 36, .671 1.00 33, .48 F
ATOM g703 C GLU 405 26.354 86.8gδ 35, .122 1.00 33, .48 F
ATOM g704 0 GLU 405 25.298 δ7.334 35. .627 1.00 33, .48 F
ATOM g705 N ALA 406 27.565 87.420 35. .351 1.00 33, .48 F
ATOM g706 CA ALA 406 27.797 8δ.56g 36. .238 1.00 33, .48 F
ATOM g707 CB ALA 406 2g.253 88.gg2 36. .158 1.00 33, .48 F
ATOM g708 C ALA 406 26.896 δg.756 35. ,8 4 1.00 33, .48 F
ATOM 7og 0 ALA 406 27.135 go.δgo 36, .325 1.00 33, .48 F
ATOM g7io N ALA 407 25.873 δg.4δδ 35. ,og2 1.00 33, .48 F
ATOM 9711 CA ALA 407 24.928 go.506 34. ,6g4 1.00 33, .48 F
ATOM 9712 CB ALA 407 24.δδ9 go.650 33. .179 1.00 33, .48 F
ATOM 9713 C ALA 407 23.5δ4 gθ.073 35. .202 1.00 33 .48 F
ATOM 9714 0 ALA 407 22.853 go.δ92 35. .758 1.00 33, .48 F
ATOM 9715 N GLU 40δ 23.26g δδ.783 35. ,040 1.00 33, ,48 F
ATOM g716 CA GLU 40δ 21.958 8δ.2δ4 35. .472 1.00 33, .48 F
ATOM g717 CB GLU 40δ 21.793 δ6.7δ0 35. ,242 1.00 33, .48 F
ATOM g718 CG GLU 408 20.337 86.298 35. ,418 1.00 33, .48 F ATOM g7ig CD GLU 408 20.220 84.776 35.,549 1.0033,.48 F
ATOM 9720 OEl GLU 408 20.4δ0 δ4.056 34. 556 1.00 33, .48 F
ATOM 9721 OE2 GLU 408 ig.877 δ4.297 36. ,658 1.00 33, .48 F
ATOM 9722 C GLU 408 21.767 δδ.581 36. ,933 1.00 33, .48 F
ATOM 9723 O GLU 408 20.667 88.443 37. 474 1.00 33, .48 F
ATOM 9724 N VAL 409 22.857 88.981 37. ,571 1.00 33, .48 F
ATOM 9725 CA VAL 4og 22.δl3 8g.331 38. ,973 1.00 33, .48 F
ATOM 9726 CB VAL 4og 24.216 δg.130 39. ,630 1.00 33, .48 F
ATOM 9727 CGl VAL 4og 25.305 δg.640 38. ,690 1.00 33, .48 F
ATOM 972δ CG2 VAL 4og 24.271 89.812 40. ,983 1.00 33, .48 F
ATOM g72g C VAL 4og 22.334 90.785 38. ,997 1.00 33, .48 F
ATOM g730 O VAL 4og 21.339 91.106 39. ,647 1.00 33 .48 F
ATOM g731 N MET 410 23.005 91.661 38. ,256 1.00 33 .48 F
ATOM g732 CA MET 410 22.563 93.048 38. ,221 1.00 33, .48 F
ATOM g733 CB MET 410 23.673 93.g7δ 37, ,699 1.00 33 .48 F
ATOM 9734 CG MET 410 24.600 g4.523 38. ,797 1.00 33, .48 F
ATOM 9735 SD MET 410 24.δ80 g6.331 38. ,634 1.00 33, .48 F
ATOM 9736 CE MET 410 26.736 g6.583 39. ,253 1.00 33 .48 F
ATOM 9737 C MET 410 21.302 g3.185 37. ,363 1.00 33, .48 F
ATOM g738 O MET 410 20.g02 g4.290 37. ,029 1.00 33, .48 F
ATOM g73g N MET 411 20.675 92.058 37. ,025 1.00 33 .48 F
ATOM 9740 CA MET 411 ig.455 92.051 36. ,202 1.00 33, .48 F
ATOM 9741 CB MET 411 ig.618 gi.125 34. ,9δ7 1.00 33, .48 F
ATOM 9742 CG MET 411 20.δ43 91.465 34, ,157 1.00 33, .48 F
ATOM 9743 SD MET 411 20.811 9θ.gδg 32. ,417 1.00 33, .48 F
ATOM 9744 CE MET 411 20.δ30 δg.iδo 32. .528 1.00 33, .48 F
ATOM g745 C MET 411 lδ.227 gi.622 37, .004 1.00 33 .48 F
ATOM 9746 O MET 411 17.104 g2.025 36, .696 1.00 33 .48 F
ATOM 9747 N LYS 412 18.445 go.797 38, .027 1.00 33 .48 F
ATOM 9748 CA LYS 412 17.360 90.348 38, .879 1.00 33 .48 F
ATOM 974g CB LYS 412 17.770 89.110 39, .674 1.00 33 .48 F
ATOM g750 CG LYS 412 17.635 δ7.7δ2 38, .930 1.00 33 .48 F
ATOM g751 CD LYS 412 17.506 δ6.632 39, .939 1.00 33 .48 F
ATOM g752 CE LYS 412 17.541 δ5.251 39, .282 1.00 33 .48 F
ATOM g753 NZ LYS 412 17.558 δ4.148 40, ,313 1.00 33 .48 F
ATOM 9754 C LYS 412 16.g53 91.455 39, .849 1.00 33 .48 F
ATOM 9755 O LYS 412 15.8g7 g2.056 39, .703 1.00 33 .48 F
ATOM 9756 N LEU 413 17.807 91.736 40, ,830 1.00 33 .48 F
ATOM 9757 CA LEU 413 17.521 92.745 41, .843 1.00 33 .48 F
ATOM 9758 CB LEU 413 18.505 92.605 42, ,996 1.00 33 .48 F
ATOM 9759 CG LEU 413 ιg.g45 92.407 42, .551 1.00 33 .48 F
ATOM 9760 CDl LEU 413 20.868 g3.032 43, .568 1.00 33 .48 F
ATOM 9761 CD2 LEU 413 20.246 go.g2i 42. .394 1.00 33 .48 F
ATOM 9762 C LEU 413 17.527 g4.177 41. .329 1.00 33 .48 F ATOM 9763 0 LEU 413 18.186 94.481 40.349 1.00 33.48 F
ATOM g764 N SER 414 16.779 95.048 42. 005 1.00 33 .48 F
ATOM g765 CA SER 414 16.664 96.456 41. 635 1.00 33 .48 F
ATOM g766 CB SER 414 15.611 96.6ig 40. ,540 1.00 33, .48 F
ATOM g767 OG SER 414 15.360 g7.ggι 40. ,269 1.00 33 .48 F
ATOM g76δ C SER 414 16.265 g7.2go 42. ,847 1.00 33 .48 F
ATOM g76 O SER 414 15.382 g6.905 43. ,600 1.00 33 .48 F
ATOM g770 N HIS 415 16.894 9δ.446 43, ,021 1.00 33, .48 F
ATOM g771 CA HIS 415 16.591 gg.276 44, ,174 1.00 33, .48 F
ATOM g772 CB HIS 415 17.005 9δ.506 45. ,420 1.00 33, .48 F
ATOM g773 CG HIS 415 16.713 99.208 46. ,706 1.00 33, .48 F
ATOM g774 CD2 HIS 415 16.139 98.765 47. .847 1.00 33 .48 F
ATOM 9775 NDl HIS 415 17.116 100.499 46, .956 1.00 33, .48 F
ATOM 9776 CEl HIS 415 16.80δ 100.821 48, .197 1.00 33, .48 F
ATOM 9777 NE2 HIS 415 16.215 9g.785 48, ,760 1.00 33, .48 F
ATOM 9778 C HIS 415 17.291 100.632 44, .113 1.00 33, .48 F
ATOM 9779 0 HIS 415 18.424 100.73g 43, ,677 1.00 33, .48 F
ATOM 9780 N PRO 416 16.614 101.6g2 44, .553 1.00 33 .48 F
ATOM 9781 CD PRO 416 15.246 101.674 45, .089 1.00 33 .48 F
ATOM 9782 CA PRO 416 17.135 103.063 44, .562 1.00 33 .48 F
ATOM 9783 CB PRO 416 16.109 103.801 45, .425 1.00 33 .48 F
ATOM 9784 CG PRO 416 14.869 103.140 45, .051 1.00 33 .48 F
ATOM 9785 C PRO 416 18.574 103.287 45, .054 1.00 33, .48 F
ATOM 9786 0 PRO 416 19.238 104.227 44, .615 1.00 33, .48 F
ATOM 9787 N LYS 417 19.042 102.440 45, .965 1.00 33, .48 F
ATOM 9788 CA LYS 417 20.383 102.587 46, .503 1.00 33, .48 F
ATOM 9789 CB LYS 417 20.370 102.452 48, .030 1.00 33, .48 F
ATOM 97go CG LYS 417 19.448 103.442 48. .721 1.00 33, .48 F
ATOM g7gι CD LYS 417 19.583 104.830 48. .099 1.00 33, .48 F
ATOM g7g2 CE LYS 417 18.477 105.772 48. .556 1.00 33, .48 F
ATOM g7 3 NZ LYS 417 18.527 106.046 50. .009 1.00 33, .48 F
ATOM g7 4 C LYS 417 21.366 101.595 45. .895 1.00 33, .48 F
ATOM 9795 0 LYS 417 22.350 101.220 46. ,518 1.00 33, .48 F
ATOM 97g6 N LEU 418 21.070 101.170 44. ,671 1.00 33, .48 F
ATOM 7g7 CA LEU 418 21.920 100.263 43. ,914 1.00 33, .48 F
ATOM g798 CB LEU 418 21.352 9δ.δ50 43. ,851 1.00 33, .48 F
ATOM 979g CG LEU 418 21.639 98.002 45. .077 1.00 33, .48 F
ATOM 9800 CDl LEU 418 20.803 98.4δδ 46. ,224 1.00 33, .48 F
ATOM 9801 CD2 LEU 418 21.333 96.572 44. ,787 1.00 33, .48 F
ATOM 9802 C LEU 418 22.020 100.799 42. ,512 1.00 33. .48 F
ATOM 9803 0 LEU 418 21.020 101.128 41. ,8g 1.00 33, .48 F
ATOM 9δ04 N VAL 419 23.244 100.903 42. ,024 1.00 33, .48 F
ATOM gsos CA VAL 419 23.497 101.383 40. ,685 1.00 33, .48 F
ATOM gδ06 CB VAL 419 24.988 101.280 40. ,377 1.00 33, .48 F ATOM g807 CGl VAL 419 25.247 101.612 38.g27 1.00 33,.48 F
ATOM 9808 CG2 VAL 419 25.754 102.204 41.301 1.00 33, .48 F
ATOM 9809 C VAL 419 22.702 100.510 3g.725 1.00 33, ,48 F
ATOM 9810 O VAL 419 22.842 99.28δ 3g.731 1.00 33, .48 F
ATOM 9811 N GLN 420 21.877 101.144 38.899 1.00 33, .48 F
ATOM 9812 CA GLN 420 21.029 100.433 37.956 1.00 33 .48 F
ATOM 9813 CB GLN 420 19.756 101.242 37.738 1.00 33 .48 F
ATOM g814 CG GLN 420 18.784 100.610 36.782 1.00 33 .48 F
ATOM gδis CD GLN 420 18.247 9g.300 37.295 1.00 33 .48 F
ATOM g816 OEl GLN 420 17.756 99-.223 38.421 1.00 33 .48 F
ATOM g817 NE2 GLN 420 18.327 9δ.257 36.471 1.00 33 .48 F
ATOM gδiδ C GLN 420 21.641 100. O 5 36.598 1.00 33 .48 F
ATOM g819 O GLN 420 22.215 100.933 35.928 1.00 33 .48 F
ATOM 9820 N LEU 421 21.502 9δ.δ26 36.196 1.00 33, .48 F
ATOM 9821 CA LEU 421 22.004 9δ.367 34.905 1.00 33, .48 F
ATOM 9822 CB LEU 421 22.173 96.δ46 34.90g 1.00 33, .48 F
ATOM 9823 CG LEU 421 22.248 g6.203 33.517 1.00 33, .48 F
ATOM 9824 CDl LEU 421 23.583 g6.4δ6 32.δ7δ 1.00 33, .48 F
ATOM 9825 CD2 LEU 421 22.033 g4.71δ 33.61δ 1.00 33, .48 F
ATOM 9826 C LEU 421 21.006 gδ.753 33.810 1.00 33 .48 F
ATOM g827 o' LEU 421 19.828 gδ.418 33.902 1.00 33, .48 F
ATOM g828 N TYR 422 21.475 g9.451 32.778 1.00 33, .48 F
ATOM 82 CA TYR 422 20.608 gg.866 31.679 1.00 33, .48 F
ATOM 9830 CB TYR 422 21.097 101.171 31.055 1.00 33, .48 F
ATOM 9831 CG TYR 422 20.830 102.427 31.857 1.00 33, .48 F
ATOM 9832 CDl TYR 422 21.526 103.5g6 31.590 1.00 33, .48 F
ATOM 9833 CEl TYR 422 21.287 104.735 32.307 1.00 33, .48 F
ATOM 9834 CD2 TYR 422 19.881 102.44δ 32.872 1.00 33, .48 F
ATOM 9835 CE2 TYR 422 19.640 103.591 33.592 1.00 33 .48 F
ATOM g836 CZ TYR 422 20.346 104.725 33.304 1.00 33 .48 F
ATOM g837 OH TYR 422 20.123 105.86g 34.021 1.00 33 .48 F
ATOM g838 C TYR 422 20.587 98.807 30.601 1.00 33, .48 F
ATOM g839 O TYR 422 19.534 98.463 30.069 1.00 33, .48 F
ATOM 9840 N GLY 423 21.765 98.300 30.268 1.00 33, .48 F
ATOM 9841 CA GLY 423 21.854 97.287 29.235 1.00 33, .48 F
ATOM 9842 C GLY 423 23.261 96.788 28.974 1.00 33 .48 F
ATOM 9843 O GLY 423 24.255 97.333 29.468 1.00 33, .48 F
ATOM 9844 N VAL 424 23.338 95.743 28.164 1.00 33, .48 F
ATOM 9845 CA VAL 424 24.603 95.127 27.827 1.00 33, .48 F
ATOM 9846 CB VAL 424 24.563 93.652 28.150 1.00 33, .48 F
ATOM 9847 CGl VAL 424 24.094 93.449 29.572 1.00 33 .48 F
ATOM 984δ CG2 VAL 424 23.639 92.961 27.185 1.00 33 .48 F
ATOM 49 C VAL 424 24.922 95.266 26.345 1.00 33, .48 F
ATOM 9850 O VAL 424 24.355 96.09g 25.63δ 1.00 33, .48 F ATOM 9851 N CYS 425 25.833 94.418 25.δ90 1.00 33.48 F
ATOM 9852 CA CYS 425 26.2g8 94.3δ7 24.513 1.00 33.48 F
ATOM 9853 CB CYS 425 27.307 g5.512 24.266 1.00 33.48 F
ATOM 9854 SG CYS 425 26.664 97.1δ7 24.119 1.00 33.48 F
ATOM 9855 c CYS 425 27.036 93.057 24.394 1.00 33.48 F
ATOM 9856 0 CYS 425 28.268 93.042 24.306 1.00 33.48 F
ATOM 9857 N LEU 426 26.307 91.944 24.39g 1.00 33.48 F
ATOM 9δ58 CA LEU 426 26.g63 90.641 24.333 1.00 33.48 F
ATOM g859 CB LEU 426 26.645 89.862 25.604 1.00 33.48 F
ATOM 9δ60 CG LEU 426 26.589 90.738 26.δ51 1.00 33.48 F
ATOM 9δ61 CDl LEU 426 26.543 89.827 28.069 1.00 33.48 F
ATOM g862 CD2 LEU 426 27.804 91.658 26.922 1.00 33.48 F
ATOM g863 C LEU 426 26.585 89.801 23.111 1.00 33.48 F
ATOM g864 O LEU 426 26.365 88.5δO 23.216 1.00 33.48 F
ATOM g865 N ILE 431 33.365 g3.563 24.591 1.00 33.48 F
ATOM gδ66 CA ILE 431 32.025 93.744 25.133 1.00 33.48 F
ATOM gδ67 CB ILE 431 31.531 92.465 25.823 1.00 33.48 F
ATOM g868 CG2 ILE 431 31.536 91.32δ 24.842 1.00 33.48 F
ATOM δ6 CGl ILE 431 32.434 92.112 26.9g5 1.00 33.48 F
ATOM δ70 CDl ILE 431 32.027 90.824 27.6g8 1.00 33.48 F
ATOM g871 C ILE 431 31.951 94.901 26.131 1.00 33.48 F
ATOM gδ72 O ILE 431 32.984 95.371 26.624 1.00 33.48 F
ATOM g873 N CYS 432 30.732 95.364 26.413 1.00 33.48 F
ATOM g874 CA CYS 432 30.541 96.461 27.355 1.00 33.48 F
ATOM g875 CB CYS 432 30.δl6 97.7g7 26.675 1.00 33.48 F
ATOM 9876 SG CYS 432 29.460 98.340 25.617 1.00 33.48 F
ATOM 9877 C CYS 432 29.135 96.485 27.g51 1.00 33.48 F
ATOM 9878 O CYS 432 28.160 96.094 27.300 1.00 33.48 F
ATOM 9879 N LEU 433 29.058 96.956 2g.ιg5 1.00 33.48 F
ATOM 9880 CA LEU 433 27.811 97.064 29.948 1.00 33.48 F
ATOM 9881 CB LEU 433 27.956 96.32g 31.279 1.00 33.48 F
ATOM 9882 CG LEU 433 27.750 g4.δl4 31.212 1.00 33.48 F
ATOM 9883 CDl LEU 433 27.981 94.353 29.800 1.00 33.48 F
ATOM 9884 CD2 LEU 433 28.661 94.100 32.194 1.00 33.48 F
ATOM 9885 C LEU 433 27.466 9δ.541 30.193 1.00 33.48 F
ATOM 9886 O LEU 433 28.361 9g.360 30.420 1.00 33.48 F
ATOM 9887 N VAL 434 26.176 gδ.8δ5 30.146 1.00 33.48 F
ATOM 9888 CA VAL 434 25.764 100.277 30.357 1.00 33.48 F
ATOM 9889 CB VAL 434 24.943 100.76δ 29.172 1.00 33.48 F
ATOM 9890 CGl VAL 434 24.933 102.2g3 29.144 1.00 33.48 F
ATOM 98gi CG2 VAL 434 25.518 100.205 27.893 1.00 33.48 F
ATOM gδg2 C VAL 434 24.966 loo.4gg 31.655 1.00 33.48 F
ATOM gβg3 O VAL 434 23.847 100.005 31.801 1.00 33.48 F
ATOM gδg4 N PHE 435 25.555 101.249 32.585 1.00 33.48 F ATOM 98 5 CA PHE 435 24.952 101.538 33..883 1.00 33,.48 F
ATOM 9896 CB PHE 435 25.953 101.294 35. ,024 1.00 33, .48 F
ATOM 9897 CG PHE 435 26.353 99.860 35. ,217 1.00 33, .48 F
ATOM 9 g8 CDl PHE 435 25.642 99.03δ 36. ,070 1.00 33, .48 F
ATOM gδ 9 CD2 PHE 435 27.461 gg.350 34. ,587 1.00 33, .48 F
ATOM 9900 CEl PHE 435 26.033 g7.746 36. ,289 1.00 33, .48 F
ATOM 9901 CE2 PHE 435 27.852 9δ.060 34, ,807 1.00 33, .48 F
ATOM 9go2 CZ PHE 435 27.138 97.257 35, ,659 1.00 33, .48 F
ATOM ggo3 C PHE 435 24.568 102.995 33, ,951 1.00 33, .48 F
ATOM 9904 0 PHE 435 25.013 103.7δ9 33, ,141 1.00 33, .48 F
ATOM 9905 N GLU 436 23.745 103.348 34, .931 1.00 33, .48 F
ATOM 9906 CA GLU 436 23.359 104.741 35, .117 1.00 33 .48 F
ATOM 9907 CB GLU 436 22.346 104.883 36, .266 1.00 33 .48 F
ATOM 9908 CG GLU 436 22.900 104.506 37, .639 1.00 33 .48 F
ATOM 9909 CD GLU 436 21.907 104.6go 38, .770 1.00 33 .48 F
ATOM 9910 OEl GLU 436 21.497 105.83g 39, .014 1.00 33 .48 F
ATOM 9911 OE2 GLU 436 21.543 103.6δ6 39, .419 1.00 33, .48 F
ATOM 9gi2 C GLU 436 24.67g 105.436 35. .471 1.00 33 .48 F
ATOM ggi3 0 GLU 436 25.620 104.7 4 35. .913 1.00 33 .48 F
ATOM g914 N PHE 437 24.753 106.742 35. .297 1.00 33, .48 F
ATOM 9gi5 CA PHE 437 25.gg2 107.444 35. .560 1.00 33, .48 F
ATOM 9916 CB PHE 437 26.271 108.358 34. .358 1.00 33, .48 F
ATOM 9 i7 CG PHE 437 27.307 109.394 34, .606 1.00 33, .48 F
ATOM 9918 CDl PHE 437 26.g47 110.717 34, .755 1.00 33, .48 F
ATOM 9919 CD2 PHE 437 28.643 109.046 34. .710 1.00 33, .48 F
ATOM 9 20 CEl PHE 437 27.8g4 111.675 35. ,002 1.00 33, .48 F
ATOM gg2i CE2 PHE 437 2g.607 110.002 34. .959 1.00 33, ,48 F
ATOM gg22 CZ PHE 437 29.230 111.316 35. ,104 1.00 33, .48 F
ATOM gg23 C PHE 437 26.022 lOδ.218 36. ,878 1.00 33, .48 F
ATOM gg24 0 PHE 437 25.225 109.126 37. .081 1.00 33 .48 F
ATOM g925 N MET 438 26.946 107.856 37. .770 1.00 33 .48 F
ATOM 9926 CA MET 438 27.076 108.521 39, .067 1.00 33, .48 F
ATOM 9 27 CB MET 438 27.595 107.538 40, ,113 1.00 33, .48 F
ATOM 9928 CG MET 438 26.780 106.238 40. ,228 1.00 33, .48 F
ATOM 9929 SD MET 438 24.997 106.37g 40. ,682 1.00 33, .48 F
ATOM 9930 CE MET 438 25.108 106.836 42. ,377 1.00 33, .48 F
ATOM 9931 C MET 438 28.023 10g.711 38. ,937 1.00 33, .48 F
ATOM 9932 0 MET 438 29.230 10g.546 38. ,855 1.00 33, .48 F
ATOM 9933 N GLU 43g 27.454 no. gi3 38. ,919 1.00 33, .48 F
ATOM 9g34 CA GLU 43 28.205 112.160 38. 753 1.00 33. .48 F
ATOM g 35 CB GLU 43g 27.237 113.338 38. 634 1.00 33, .48 F
ATOM g936 CG GLU 43g 26.723 113.813 39. ,9δ4 1.00 33, .48 F
ATOM 9937 CD GLU 43g 26.206 115.249 39. ,962 1.00 33, .48 F
ATOM 9g38 OEl GLU 439 25.068 115.449 39. ,474 1.00 33, .48 F ATOM 9g3 OE2 GLU 439 26.92g 116.182 40.425 1.00 33.48 F
ATOM 9940 C GLU 439 2g.261 112.534 3g.803 1.00 33.48 F
ATOM 9g41 O GLU 439 2g.618 113.700 3g.913 1.00 33.48 F
ATOM g942 N HIS 440 2g.751 111.582 40.584 1.00 33.48 F
ATOM 9943 CA HIS 440 30.7δO 111.895 41.576 1.00 33.48 F
ATOM 9g44 CB HIS 440 30.163 112.341 42.897 1.00 33.48 F
ATOM gg45 CG HIS 440 2g.4δ3 113.668 42.829 1.00 33.48 F
ATOM gg46 CD2 HIS 440 2δ.l76 114.004 42.927 1.00 33.48 F
ATOM 9947 NDl HIS 440 30.16g 114.850 42.649 1.00 33.48 F
ATOM 9g48 CEl HIS 440 2g.314 115.859 42.642 1.00 33.48 F
ATOM 4 NE2 HIS 440 2δ.097 115.372 42.809 1.00 33.48 F
ATOM g950 C HIS 440 31.668 110.689 41.825 1.00 33.48 F
ATOM 9 51 O HIS 440 32.301 110.581 42.875 1.00 33.4δ F
ATOM 9952 N GLY 441 31.706109.780 40.857 1.00 33.4δ F
ATOM 9953 CA GLY 441 32.531 108.602 40.995 1.00 33.4δ F
ATOM 9954 C GLY 441 32.374107.89δ 42.322 1.00 33.48 F
ATOM 9g55 O GLY 441 31.395 lOδ . lOδ 43.026 1.00 33.48 F
ATOM 9956 N CYS 442 33.367 107. OδO 42.662 1.00 33.4δ F
ATOM 9957 CA CYS 442 33.370 106.281 43.880 1.00 33.4δ F
ATOM 9 58 CB CYS 442 34.454 105.211 43.775 1.00 33.48 F
ATOM 995g SG CYS 442 36.115 105.878 43.563 1.00 33.48 F
ATOM 9960 C CYS 442 33.532 107.049 45.182 1.00 33.48 F
ATOM 9961 O CYS 442 34.220 108.062 45.240 1.00 33.48 F
ATOM 9 62 N LEU 443 32.900 106.526 46.231 1.00 33.48 F
ATOM 9963 CA LEU 443 32.911 107.138 47.548 1.00 33.4δ F
ATOM 9 64 CB LEU 443 32.021 106.323 48.503 1.00 33.48 F
ATOM 9965 CG LEU 443 31.921 106.745 49.g76 1.00 33.48 F
ATOM 9g66 CDl LEU 443 31.429 108.168 50.108 1.00 33.4δ F
ATOM 9967 CD2 LEU 443 30.g99 105.806 50.6g7 1.00 33.4δ F
ATOM 9g6δ C LEU 443 34.287 107.364 48.168 1.00 33.48 F
ATOM g969 O LEU 443 34.506 108.396 48.7gg 1.00 33.48 F
ATOM 7o N SER 444 35.217 106.429 47.992 1.00 33.48 F
ATOM g971 CA SER 444 36.553 106.585 48.580 1.00 33.48 F
ATOM 9972 CB SER 444 37.451105.412 48.226 1.00 33.48 F
ATOM 9973 OG SER 444 37.661105.352 46.835 1.00 33.48 F
ATOM 9974 C SER 444 37.221107.866 48.132 1.00 33.48 F
ATOM 975 O SER 444 37.725 108.617 48.955 1.00 33.48 F
ATOM g976 N ASP 445 37.226 108.122 46.829 1.00 33.48 F
ATOM 9977 CA ASP 445 37.82δ lo .353 46.328 1.00 33.4δ F
ATOM 997δ CB ASP 445 37.δl6 109.396 44.805 1.00 33.48 F
ATOM 9979 CG ASP 445 3δ.419 108.164 44.1δ4 1.00 33.48 F
ATOM 9980 ODl ASP 445 39.447 107.661 44.70δ 1.00 33.4δ F
ATOM 981 OD2 ASP 445 37.δ70 107.709 43.15g 1.00 33.48 F
ATOM 9982 C ASP 445 37.035 110.540 46.852 1.00 33.48 F ATOM 9g83 0 ASP 445 37.566111.401 47.564 1.00 33.48 F
ATOM gg84 N TYR 446 35.752 110.565 46.494 1.00 33 .48 F
ATOM ggδ5 CA TYR 446 34.δ47 111.625 46.903 1.00 33 .48 F
ATOM gg86 CB TYR 446 33.39δ 111.127 46.852 1.00 33 .48 F
ATOM ggδ7 CG TYR 446 32.3gg 112.241 47.031 1.00 33 .4δ F
ATOM ggδδ CDl TYR 446 31.991113.013 45.94g 1.00 33 .48 F
ATOM g 89 CEl TYR 446 31.171114.107 46.130 1.00 33 .48 F
ATOM 9g o CD2 TYR 446 31.948 112.594 48.2g7 1.00 33 .48 F
ATOM gg9i CE2 TYR 446 31.135 113.681 48.485 1.00 33 .48 F
ATOM 9992 CZ TYR 446 30.747 114.435 47.405 1.00 33 .48 F
ATOM 9 g3 OH TYR 446 29.924 115.516 47.600 1.00 33 .48 F
ATOM 9994 C TYR 446 35.191112.083 48.315 1.00 33 .48 F
ATOM 9995 0 TYR 446 35.565 113.233 48.533 1.00 33 .48 F
ATOM 9 g6 N LEU 447 35.070 111.167 4g.268 1.00 33 .48 F
ATOM ggg7 CA LEU 447 35.372 111.456 50.661 1.00 33 .48 F
ATOM gggδ CB LEU 447 35.438 110.163 51.453 1.00 33 .48 F
ATOM ggg9 CG LEU 447 34.105 109.488 51.6g6 1.00 33 .48 F
ATOM 10000 CDl LEU 447 34.320 108.05δ 52.14δ 1.00 33 .48 F
ATOM 10001 CD2 LEU 447 33.342 110.305 52.727 1.00 33 .48 F
ATOM 10002 C LEU 447 36.69g 112.169 50.78δ 1.00 33 .48 F
ATOM 10003 0 LEU 447 36.776 113.248 51.371 1.00 33 .48 F
ATOM 10004 N ARG 448 37.750 111.549 50.254 1.00 33 .48 F
ATOM 10005 CA ARG 448 3g.085 112.130 50.314 1.00 33 .48 F
ATOM 10006 CB ARG 448 40.075 111.235 4g.568 1.00 33 .48 F
ATOM 10007 CG ARG 448 40.257 109.858 50.189 1.00 33 .48 F
ATOM 10008 CD ARG 448 40.730 108. δ3δ 49.162 1.00 33.48 F
ATOM 10009 NE ARG 448 40.785 107.4δ4 49.714 1.00 33 .48 F
ATOM 10010 CZ ARG 448 40.80g 106.376 48.966 1.00 33 .48 F
ATOM 10011 NHl ARG 448 40.770 106.475 47.635 1.00 33 .48 F
ATOM 10012 NH2 ARG 448 40.8 9 105.171 49.536 1.00 33 .48 F
ATOM 10013 C ARG 44δ 39.104 113.544 49.719 1.00 33 .48 F
ATOM 10014 0 ARG 44δ 39.258 114.523 50.444 1.00 33 .48 F
ATOM 10015 N THR 449 38.931113.651 48.408 1.00 33.48 F
ATOM 10016 CA THR 449 38.943 114.940 47.734 1.00 33 .48 F
ATOM 10017 CB THR 449 38.698 114.782 46.234 1.00 33 .48 F
ATOM 10018 OGl THR 449 37.435 114.139 46.031 1.00 33 .48 F
ATOM 10019 CG2 THR 449 39.786 113.946 45.595 1.00 33 .48 F
ATOM 10020 C THR 449 37.873 115.888 48.230 1.00 33 .48 F
ATOM 10021 0 THR 449 37.424 116.741 47.475 1.00 33 .48 F
ATOM 10022 N GLN 450 37.453 115.751 49.480 1.00 33 .48 F
ATOM 10023 CA GLN 450 36.406 116.605 50.039 1.00 33 .48 F
ATOM 10024 CB GLN 450 35.024 116.029 49.697 1.00 33 .48 F
ATOM 10025 CG GLN 450 34.633 116.128 48.230 1.00 33 .48 F
ATOM 10026 CD GLN 450 34.156 117.519 47.874 1.00 33 .48 F ATOM 10027 OEl GLN 450 32.g82 117.842 48.051 1.00 33.48 F
ATOM 10028 NE2 GLN 450 35.074 118.366 47.39g 1.00 33.48 F
ATOM 1002g c GLN 450 36.571 116.643 51.545 1.00 33.4δ F
ATOM 10030 0 GLN 450 35.δl4 117.306 52.252 1.00 33.4δ F
ATOM 10031 N ARG 451 37.568 115.899 52.016 1.00 33.48 F
ATOM 10032 CA ARG 451 37.891 115.7δ6 53.433 1.00 33.48 F
ATOM 10033 CB ARG 451 39.321 115.230 53.588 1.00 33.48 F
ATOM 10034 CG ARG 451 39.684 114.762 54.gg6 1.00 33.48 F
ATOM 10035 CD ARG 451 40.δ56 113.773 55.024 1.00 33.48 F
ATOM 10036 NE ARG 451 40.62δ 112.617 54.155 1.00 33.48 F
ATOM 10037 CZ ARG 451 41.323 111.478 54.191 1.00 33.48 F
ATOM 10038 NHl ARG 451 42.307 111.306 55.060 1.00 33.48 F
ATOM 1003g NH2 ARG 451 41.038 110.504 53.33g 1.00 33.48 F
ATOM 10040 C ARG 451 37.771 117.160 54.067 1.00 33.48 F
ATOM 10041 O ARG 451 38.074 118.160 53.431 1.00 33.48 F
ATOM 10042 N GLY 452 37.302 117.217 55.306 1.00 33.48 F
ATOM 10043 CA GLY 452 37.17g 118.505 55.g65 1.00 33.4δ F
ATOM 10044 C GLY 452 35.8gg 119.292 55.722 1.00 33.48 F
ATOM 10045 0 GLY 452 35.538 120.144 56.53g 1.00 33.48 F
ATOM 10046 N LEU 453 35.202 119.018 54.620 1.00 33.4δ F
ATOM 10047 CA LEU 453 33.962 119.730 54.31δ 1.00 33.4δ F
ATOM 10048 CB LEU 453 33.876 120.02g 52.830 1.00 33.4δ F
ATOM 1004g CG LEU 453 34.762 121.197 52.417 1.00 33.4δ F
ATOM 10050 CDl LEU 453 36.155 120.701 52.078 1.00 33.4δ F
ATOM 10051 CD2 LEU 453 34.132 121.892 51.231 1.00 33.4δ F
ATOM 10052 C LEU 453 32.648 119.095 54.756 1.00 33.4δ F
ATOM 10053 O LEU 453 31.6δ0 119.799 54.975 1.00 33.4δ F
ATOM 10054 N PHE 454 32.607 117.778 54.887 1.00 33.4δ F
ATOM 10055 CA PHE 454 31.3δ7 117.093 55.281 1.00 33.4δ F
ATOM 10056 CB PHE 454 31.579 115.597 55.182 1.00 33.4δ F
ATOM 10057 CG PHE 454 31.935 115.137 53.834 1.00 33.4δ F
ATOM 10058 CDl PHE 454 31.052 115.297 52.787 1.00 33.48 F
ATOM loosg CD2 PHE 454 33.142 114.525 53.606 1.00 33.48 F
ATOM 10060 CEl PHE 454 31.36δ 114.850 51.527 1.00 33.4δ F
ATOM 10061 CE2 PHE 454 33.467 114.075 52.356 1.00 33.4δ F
ATOM 10062 CZ PHE 454 32.578 114.235 51.310 1.00 33.4δ F
ATOM 10063 C PHE 454 30.96g 117.396 56.696 1.00 33.4δ F
ATOM 10064 0 PHE 454 31.798 117.710 57.533 1.00 33.4δ F
ATOM 10065 N ALA 455 29.676 117.267 56.g61 1.00 33.4δ F
ATOM 10066 CA ALA 455 29.12g 117.478 58.2gi 1.00 33.48 F
ATOM 10067 CB ALA 455 27.g21118.381 5δ.220 1.00 33.48 F
ATOM 10068 C ALA 455 28.727 116.113 5δ.848 1.00 33.48 F
ATOM 1006g 0 ALA 455 28. ogg 115.311 58.162 1.00 33.48 F
ATOM 10070 N ALA 456 29.092 115.856 60.0g6 1.00 33.48 F ATOM 10071 CA ALA 456 28.782 114.586 60.732 1.00 33,,48 F
ATOM 10072 CB ALA 456 28.778 114.752 62.241 1.00 33, .48 F
ATOM 10073 c ALA 456 27.44g 114.025 60.256 1.00 33, .48 F
ATOM 10074 0 ALA 456 27.371 112.873 59.847 1.00 33, .48 F
ATOM 10075 N GLU 457 26.406 114.844 60.302 1.00 33, .48 F
ATOM 10076 CA GLU 457 25.083 114.406 59.868 1.00 33 .48 F
ATOM 10077 CB GLU 457 24.05g 115.554 59.987 1.00 33 .48 F
ATOM 10078 CG GLU 457 24.478 116.872 59.321 1.00 33 .48 F
ATOM 1007g CD GLU 457 23.500 118.014 59.601 1.00 33 .48 F
ATOM lOOδO OEl GLU 457 22.308 117.854 59.240 1.00 33 .48 F
ATOM 10081 OE2 GLU 457 23.g25 119.059 60.178 1.00 33 .48 F
ATOM 10082 c GLU 457 25.129 113.873 58.446 1.00 33 .48 F
ATOM 10083 0 GLU 457 24.501 112.869 58.137 1.00 33 .48 F
ATOM 10084 N THR 458 25.8δl 114.540 57.584 1.00 33 .48 F
ATOM 10085 CA THR 458 26.027 114.106 56.200 1.00 33 .48 F
ATOM 10086 CB THR 458 26.854 115.100 55.414 1.00 33, .48 F
ATOM 10087 OGl THR 458 26.104 116.299 55.260 1.00 33, .48 F
ATOM 10088 CG2 THR 45δ 27.195 114.553 54.054 1.00 33, .48 F
ATOM loosg c THR 45δ 26.729 112.750 56.123 1.00 33, .48 F
ATOM ιoogo 0 THR 45δ 26.393 111.892 55.304 1.00 33, .48 F
ATOM ιoogι N LEU 45 27.726112.586 56.984 1.00 33 .48 F
ATOM ιoog2 CA LEU 45 28.495 111.365 57.064 1.00 33 .48 F
ATOM ιoog3 CB LEU 45 29.542 111.510 58.163 1.00 33 .48 F
ATOM 10094 CG LEU 45 30.429 112.733 57.927 1.00 33, .48 F
ATOM 10095 CDl LEU 45 31.359 112.934 59.0g5 1.00 33, .48 F
ATOM 10096 CD2 LEU 45g 31.198 112.556 56.63g 1.00 33, .48 F
ATOM 10097 C LEU 45g 27.511 110.268 57.3g9 1.00 33, .48 F
ATOM 1009δ 0 LEU 45g 27.297 109.346 56.614 1.00 33 .48 F
ATOM loogg N LEU 460 26.900 110.385 58.56δ 1.00 33 .48 F
ATOM 10100 CA LEU 460 25.913 109.418 59.001 1.00 33 .48 F
ATOM 10101 CB LEU 460 25.166 109.950 60.218 1.00 33 .48 F
ATOM 10102 CG LEU 460 24.074 109.027 60.750 1.00 33 .48 F
ATOM 10103 CDl LEU 460 24.720107.974 61.626 1.00 33 .48 F
ATOM 10104 CD2 LEU 460 23.047 109.818 61.533 1.00 33, .48 F
ATOM 10105 C LEU 460 24.933 109.232 57.854 1.00 33 .48 F
ATOM 10106 0 LEU 460 24.338 108.175 57.67g 1.00 33, .48 F
ATOM 10107 N GLY 461 24.779 110.281 57.065 1.00 33, .48 F
ATOM lOlOδ CA GLY 461 23.85δ 110.231 55.953 1.00 33, .48 F
ATOM ιoιog C GLY 461 24.161109.151 54.951 1.00 33 .48 F
ATOM 10110 0 GLY 461 23.297 108.331 54.654 1.00 33, .48 F
ATOM 10111 N MET 462 25.385 10g.154 54.428 1.00 33, .48 F
ATOM 10112 CA MET 462 25.804 108.175 53.433 1.00 33 .48 F
ATOM 10113 CB MET 462 27.185 108.525 52.900 1.00 33 .48 F
ATOM 10114 CG MET 462 27.766 10g.758 53.505 1.00 33 .48 F ATOM 10115 SD MET 462 29.282 110.183 52.692 1.00 33.48 F
ATOM 10116 CE MET 462 28.747 111.456 51.625 1.00 33 .48 F
ATOM 10117 C MET 462 25.797 106.755 53.9δO 1.00 33 .48 F
ATOM 10118 O MET 462 25.563 105.813 53.235 1.00 33 .48 F
ATOM 10119 N CYS 463 26.054 106.5g7 55.274 1.00 33, .48 F
ATOM 10120 CA CYS 463 26.024 105.274 55.868 1.00 33, .48 F
ATOM 10121 CB CYS 463 26.447 105.331 57.326 1.00 33, .48 F
ATOM 10122 SG CYS 463 2δ.203 105.478 57.54g 1.00 33, .48 F
ATOM 10123 C CYS 463 24.623 104.6go 55.78δ 1.00 33, .48 F
ATOM 10124 0 CYS 463 24.454 103.488 55.636 1.00 33, .48 F
ATOM 10125 N LEU 464 23.619 105.552 55.g02 1.00 33, .48 F
ATOM 10126 CA LEU 464 22.232 105.136 55.843 1.00 33, .48 F
ATOM 10127 CB LEU 464 21.322 106.275 56.2gδ 1.00 33, .48 F
ATOM 10128 CG LEU 464 ig.δ55 105. g43 56.5gδ 1.00 33, .48 F
ATOM 10129 CDl LEU 464 19.711 105.121 57.860 1.00 33, .48 F
ATOM 10130 CD2 LEU 464 19.110 107.231 56.764 1.00 33, .48 F
ATOM 10131 C LEU 464 21.890 104.72δ 54.423 1.00 33, .48 F
ATOM 10132 0 LEU 464 21.150 103.776 54.20g 1.00 33 .48 F
ATOM 10133 N ASP 465 22.425 105.440 53.443 1.00 33 .48 F
ATOM 10134 CA ASP 465 22.140105.075 52.065 1.00 33 .48 F
ATOM 10135 CB ASP 465 22.806 106.041 51.070 1.00 33, .48 F
ATOM 10136 CG ASP 465 22.116 107.404 51.006 1.00 33, .48 F
ATOM 10137 ODl ASP 465 22.330 108.142 50.026 1.00 33, .48 F
ATOM 10138 OD2 ASP 465 21.369 107.750 51.939 1.00 33, .48 F
ATOM 10139 C ASP 465 22.640 103.656 51.814 1.00 33, .48 F
ATOM 10140 0 ASP 465 21.908 102.δOδ 51.319 1.00 33, .48 F
ATOM 10141 N VAL 466 23.885 103.3g2 52.173 1.00 33, .48 F
ATOM 10142 CA VAL 466 24.461102.076 51.960 1.00 33, .48 F
ATOM 10143 CB VAL 466 25.944102.030 52.451 1.00 33, .48 F
ATOM 10144 CGl VAL 466 26.480 100.620 52.346 1.00 33, .48 F
ATOM 10145 CG2 VAL 466 26.804 102.96δ 51.626 1.00 33, .48 F
ATOM 10146 C VAL 466 23.650 100.992 52.671 1.00 33, .48 F
ATOM 10147 0 VAL 466 23.409 99.914 52.122 1.00 33, .48 F
ATOM 10148 N CYS 467 23.215 101.290 53.889 1.00 33, .48 F
ATOM 10149 CA CYS 467 22.460 100.340 54.694 1.00 33, .48 F
ATOM 10150 CB CYS 467 22.276 100.904 56.093 1.00 33, .48 F
ATOM 10151 SG CYS 467 22.001 99.675 57.347 1.00 33, .48 F
ATOM 10152 C CYS 467 21.105 9g.9δ5 54.090 1.00 33, .48 F
ATOM 10153 0 CYS 467 20.582 9δ.902 54.327 1.00 33, .48 F
ATOM 10154 N GLU 468 20.53g 100.906 53.319 1.00 33, .48 F
ATOM 10155 CA GLU 468 ig.256 100.676 52.673 1.00 33, .48 F
ATOM 10156 CB GLU 468 18.742 101.950 52.009 1.00 33, .48 F
ATOM 10157 CG GLU 468 lδ .001102.910 52.926 1.00 33, .48 F
ATOM 10158 CD GLU 468 17.701104.242 52.244 1.00 33, .48 F ATOM 10159 OEl GLU 468 17.140104.,209 51.,119 1.0033,.48 F
ATOM 10160 OE2 GLU 468 lδ.026 105. ,310 52. ,831 1.00 33, .48 F
ATOM 10161 C GLU 468 19.42δ gg. ,623 51. ,605 1.00 33, .48 F
ATOM 10162 O GLU 46δ 18.638 98. ,687 51. ,503 1.00 33, .48 F
ATOM 10163 N GLY 469 20.455 gg. ,798 50. ,7δ6 1.00 33, .48 F
ATOM 10164 CA GLY 469 20.711 98. ,840 49. ,732 1.00 33, .48 F
ATOM 10165 C GLY 46g 21.133 97. ,528 50. ,349 1.00 33, .48 F
ATOM 10166 O GLY 46g 20.686 96. ,459 49. ,944 1.00 33, .48 F
ATOM 10167 N MET 470 22.002 97. ,59g 51, .341 1.00 33 .48 F
ATOM 10168 CA MET 470 22.430 96, .381 51, .974 1.00 33, .48 F
ATOM 10169 CB MET 470 23.378 96. .682 53, .128 1.00 33 .48 F
ATOM 10170 CG MET 470 24.780 97. .046 52, .683 1.00 33, .48 F
ATOM 10171 SD MET 470 25.460 95. , 3g 51, .530 1.00 33, .48 F
ATOM 10172 CE MET 470 25.730 96. .δsg 50, .138 1.00 33 .48 F
ATOM 10173 C MET 470 21.212 95. ,623 52, .470 1.00 33, .48 F
ATOM 10174 O MET 470 21.136 94. ,4og 52, ,324 1.00 33, .48 F
ATOM 10175 N ALA 471 20.251 96, ,33δ 53, .044 1.00 33, .48 F
ATOM 10176 CA ALA 471 19.037 95, ,705 53, ,545 1.00 33, ,48 F
ATOM 10177 CB ALA 471 18.153 96, .725 54, .183 1.00 33, .48 F
ATOM 10178 C ALA 471 18.307 95. .043 52. ,395 1.00 33, .48 F
ATOM 10179 O ALA 471 17.766 93. .941 52, .540 1.00 33, .48 F
ATOM 10180 N TYR 472 18.2δ9 95. .722 51, .249 1.00 33, .48 F
ATOM 10181 CA TYR 472 17.635 95, ,190 50, .062 1.00 33, .48 F
ATOM 10182 CB TYR 472 17.δ04 96, .128 48. .871 1.00 33, .48 F
ATOM 10183 CG TYR 472 17.244 95, .549 47, ,58δ 1.00 33 .48 F
ATOM 10184 CDl TYR 472 15.δ82 95, .548 47, .337 1.00 33, .48 F
ATOM 10185 CEl TYR 472 15.368 94, .972 46, .195 1.00 33, .48 F
ATOM 10186 CD2 TYR 472 18.074 94, ,g56 46, ,651 1.00 33, .48 F
ATOM 10187 CE2 TYR 472 17.566 94, ,378 45, .511 1.00 33, .48 F
ATOM 10188 CZ TYR 472 16.215 94, ,3δδ 45, ,2δ7 1.00 33 .48 F
ATOM 10189 OH TYR 472 15.706 93, .812 44, .147 1.00 33, .48 F
ATOM 10190 C TYR 472 18.242 93. ,83g 49, .715 1.00 33, .48 F
ATOM 10191 O TYR 472 17.53g 92, ,δ3g 49, .644 1.00 33, .48 F
ATOM 10192 N LEU 473 19.551 93, .δog 49, ,503 1.00 33, .48 F
ATOM 10193 CA LEU 473 20.224 92, .564 49, .165 1.00 33, .48 F
ATOM 10194 CB LEU 473 21.716 92, ,δ00 48. .977 1.00 33, .48 F
ATOM 10195 CG LEU 473 22.134 93, ,602 47. .756 1.00 33, .48 F
ATOM 10196 CDl LEU 473 23.595 94, ,003 47. ,δ75 1.00 33, .48 F
ATOM 10197 CD2 LEU 473 21.893 92. ,766 46. .519 1.00 33, .48 F
ATOM 10198 C LEU 473 20.030 91. ,524 50, ,252 1.00 33, .48 F
ATOM 10199 O LEU 473 19.800 90, ,347 49, .967 1.00 33, .48 F
ATOM 10200 N GLU 474 20.119 91. ,g60 51. .501 1.00 33, .48 F
ATOM 10201 CA GLU 474 i9.gδ4 91. ,034 52, .602 1.00 33, .48 F
ATOM 10202 CB GLU 474 20.02g 91. ,762 53, ,g27 1.00 33, .48 F ATOM 10203 CG GLU 474 lg.ssg gθ.828 55..095 1.0033,.48 F
ATOM 10204 CD GLU 474 ig.5δ2 91.574 56. .365 1.00 33, .48 F
ATOM 10205 OEl GLU 474 20.441 92.3g4 56. .763 1.00 33, .48 F
ATOM 10206 OE2 GLU 474 18.501 91.349 56, .958 1.00 33, .48 F
ATOM 10207 C GLU 474 18.715 90.200 52, .540 1.00 33, .48 F
ATOM 10208 0 GLU 474 18.72g 89.007 52, ,861 1.00 33, .48 F
ATOM 1020g N GLU 475 17.601 90.δ01 52. ,150 1.00 33, .48 F
ATOM 10210 CA GLU 475 16.40g δg.gδ7 52. .083 1.00 33, .48 F
ATOM 10211 CB GLU 475 15.172 go.7gg 52, .421 1.00 33, .48 F
ATOM 10212 CG GLU 475 14.714 91.766 51, ,3g4 1.00 33, .48 F
ATOM 10213 CD GLU 475 13.563 g2.550 51, ,g47 1.00 33, .48 F
ATOM 10214 OEl GLU 475 12.742 91.904 52, ,641 1.00 33, .48 F
ATOM 10215 OE2 GLU 475 13.476 g3.7δ3 51. .715 1.00 33, .48 F
ATOM 10216 C GLU 475 16.291 δ9.341 50, .716 1.00 33, .48 F
ATOM 10217 0 GLU 475 15.δδ9 δδ.lδ6 50, .604 1.00 33, .48 F
ATOM 10218 N ALA 476 16.656 90.067 49, ,66g 1.00 33, .48 F
ATOM 10219 CA ALA 476 16.606 δ9.4δ5 48, .341 1.00 33, .48 F
ATOM 10220 CB ALA 476 17.063 go.4δ2 47, .3og 1.00 33 .48 F
ATOM 10221 C ALA 476 17.54g δδ.2δδ 48, .371 1.00 33, .48 F
ATOM 10222 0 ALA 476 17.622 87.514 47, .426 1.00 33, .48 F
ATOM 10223 N CYS 477 lδ.2δ2 88.151 49, .467 1.00 33, .48 F
ATOM 10224 CA CYS 477 ig.202 87.040 49. .627 1.00 33, .48 F
ATOM 10225 CB CYS 477 lδ.465 δ5.7ig 49, ,4g6 1.00 33, .48 F
ATOM 10226 SG CYS 477 17.5g3 85.2g2 50, .991 1.00 33, .48 F
ATOM 10227 C CYS 477 20.416 87.007 48. .730 1.00 33, .48 F
ATOM 10228 0 CYS 477 20.96δ 85.g44 48, .486 1.00 33, .48 F
ATOM 10229 N VAL 478 20.δ25 88.157 48, .219 1.00 33, .48 F
ATOM 10230 CA VAL 478 22.034 88.191 47, .419 1.00 33, .48 F
ATOM 10231 CB VAL 47δ 22.059 89.344 46, .407 1.00 33, .48 F
ATOM 10232 CGl VAL 47δ 23.43δ 8g.406 45, .743 1.00 33, .48 F
ATOM 10233 CG2 VAL 47δ 20.96δ 89.159 45, .370 1.00 33, .48 F
ATOM 10234 C VAL 47δ 23.105 88.485 48. .445 1.00 33, .48 F
ATOM 10235 0 VAL 47δ 22.δ26 89.089 49, .476 1.00 33, .48 F
ATOM 10236 N ILE 479 24.326 88.053 48, .188 1.00 33, .48 F
ATOM 10237 CA ILE 479 25.3gg 88.341 49, .123 1.00 33 .48 F
ATOM 10238 CB ILE 479 26.118 87.070 49, .610 1.00 33, .48 F
ATOM 10239 CG2 ILE 479 27.323 87.458 50, .457 1.00 33 .48 F
ATOM 10240 CGl ILE 479 25.162 86.ig7 50, .417 1.00 33, .48 F
ATOM 10241 CDl ILE 479 25.850 85.035 51. ,071 1.00 33, .48 F
ATOM 10242 C ILE 47 26.421 8g.233 48. .458 1.00 33, .48 F
ATOM 10243 0 ILE 47g 27.066 8δ.δ47 47, .481 1.00 33, .48 F
ATOM 10244 N HIS 480 26.546 gθ.445 48, ,972 1.00 33, .48 F
ATOM 10245 CA HIS 480 27.522 91.372 48. ,434 1.00 33, .48 F
ATOM 10246 CB HIS 480 27.271 92.76δ 48. ,9g8 1.00 33, .48 F ATOM 10247 CG HIS 480 28.016 93.842 48.,282 1.0033,.48 F
ATOM 1024δ CD2 HIS 480 27.7gθ g5.170 48. ,183 1.00 33 .48 F
ATOM 1024g NDl HIS 480 2g.l20 g3.582 47. ,506 1.00 33, .48 F
ATOM 10250 CEl HIS 480 2g.540 g4.703 46, ,950 1.00 33, .48 F
ATOM 10251 NE2 HIS 480 28.74δ 95.682 47. ,343 1.00 33 .48 F
ATOM 10252 C HIS 4δ0 28.846 90.834 48. ,g66 1.00 33 .48 F
ATOM 10253 0 HIS 4δ0 28.972 go.584 50, ,166 1.00 33 .48 F
ATOM 10254 N ARG 481 29.δ42 go.625 48, ,126 1.00 33 .48 F
ATOM 10255 CA ARG 481 31.072 go.113 48, ,715 1.00 33 .48 F
ATOM 10256 CB ARG 481 31.533 8δ.δ54 47. ,g73 1.00 33 .48 F
ATOM 10257 CG ARG 481 30.50g δ7.738 47. ,g26 1.00 33 .48 F
ATOM 1025δ CD ARG 481 30.703 86. goo 46, ,670 1.00 33 .48 F
ATOM 1025g NE ARG 481 31.883 86.046 46, ,747 1.00 33 .48 F
ATOM 10260 CZ ARG 481 31.863 δ4.7δ6 47, .179 1.00 33 .48 F
ATOM 10261 NHl ARG 481 30.718 δ4.225 47, .569' 1.00 33 .48 F
ATOM 10262 NH2 ARG 481 32.992 δ4.0g2 47. .234 1.00 33, .48 F
ATOM 10263 C ARG 481 32.192 91.156 48. .737 1.00 33, .48 F
ATOM 10264 0 ARG 481 33.246 go.g44 49. ,325 1.00 33, .48 F
ATOM 10265 N ASP 482 31.941 92.297 48. .120 1.00 33, .48 F
ATOM 10266 CA ASP 482 32.938 93.343 48. .042 1.00 33, .48 F
ATOM 10267 CB ASP 482 33.358 g3.4g4 46. .576 1.00 33 .48 F
ATOM 1026δ CG ASP 482 34.774 g4.006 46, ,415 1.00 33, .48 F
ATOM 1026g ODl ASP 482 35.048 g5.159 46, ,794 1.00 33, .48 F
ATOM 10270 OD2 ASP 482 35.619 93.242 45. .902 1.00 33 .48 F
ATOM 10271 C ASP 482 32.38δ 94.667 48. .580 1.00 33 .48 F
ATOM 10272 0 ASP 482 32.456 95.6g8 47, .914 1.00 33 .48 F
ATOM 10273 N LEU 483 31.836 g4.658 49, .783 1.00 33 .48 F
ATOM 10274 CA LEU 483 31.305 gs.goi 50, .306 1.00 33 .48 F
ATOM 10275 CB LEU 483 30.277 95.635 51, ,39δ 1.00 33, .48 F
ATOM 10276 CG LEU 483 29.205 96.696 51, .670 1.00 33, .48 F
ATOM 10277 CDl LEU 483 29.000 96.789 53, .169 1.00 33, .48 F
ATOM 1027δ CD2 LEU 483 29.591 98.040 51. .110 1.00 33, .48 F
ATOM 1027g C LEU 483 32.413 96.772 50, .861 1.00 33 .48 F
ATOM 10280 0 LEU 483 32.804 96.632 52, .015 1.00 33 .48 F
ATOM 10281 N ALA 484 32.921 97.671 50, .032 1.00 33- .48 F
ATOM 10282 CA ALA 4δ4 33.965 98.5g2 50. .461 1.00 33, .48 F
ATOM 10283 CB ALA 484 35.310 gδ.i2g 49. .959 1.00 33, .48 F
ATOM 10284 C ALA 484 33.648 99.g76 49, .917 1.00 33, .48 F
ATOM 10285 0 ALA 484 33.032 100.109 48, .862 1.00 33 .48 F
ATOM 102δ6 N ALA 4δ5 34.078 loi. ooδ 50, .631 1.00 33 .48 F
ATOM 102δ7 CA ALA 4δ5 33.812 102.37δ 50, .207 1.00 33 .48 F
ATOM 102δδ CB ALA 4δ5 34.399 103.355 51. .189 1.00 33, .48 F
ATOM 1028g C ALA 485 34.339 102.674 48. ,824 1.00 33, .48 F
ATOM i02go 0 ALA 485 34.124 103.760 48. ,3og 1.00 33 .48 F ATOM 10291 N ARG 486 35.034 101.718 48,.219 1.0033.48 F
ATOM 10292 CA ARG 486 35.572 101. g22 46, .879 1.00 33 .48 F
ATOM 10293 CB ARG 486 36.897 101.177 46, .707 1.00 33 .48 F
ATOM 10294 CG ARG 486 36.797 gg.654 46, . 7δg 1.00 33 .48 F
ATOM 10295 CD ARG 486 38.178 99.048 46, .g72 1.00 33 .48 F
ATOM 10296 NE ARG 486 38.131 97.δ27 47, .757 1.00 33 .48 F
ATOM 10297 CZ ARG 486 37.656 g6.6δ3 47, ,29δ 1.00 33 .48 F
ATOM 1029δ NHl ARG 486 37.19δ 96.611 46, .054 1.00 33 .48 F
ATOM 10299 NH2 ARG 486 37.620 95.620 48, ,0δ5 1.00 33, .48 F
ATOM 10300 C ARG 486 34.57δ 101.444 45, ,δ35 1.00 33 .48 F
ATOM 10301 O ARG 486 34.630 101.877 44, ,6δδ 1.00 33 .48 F
ATOM 10302 N ASN 487 33.673 100.555 46, .243 1.00 33 .48 F
ATOM 10303 CA ASN 487 32.652 100.016 45, .349 1.00 33 .48 F
ATOM 10304 CB ASN 487 32.263 98.58δ 45, .745 1.00 33 .48 F
ATOM 10305 CG ASN 487 33.446 g7.640 45. ,771 1.00 33 .48 F
ATOM 10306 ODl ASN 487 34.039 97.335 44, .742 1.00 33 .48 F
ATOM 10307 ND2 ASN 487 33.796 97.173 46, ,95 1.00 33 .48 F
ATOM 1030δ C ASN 487 31.404 100.876 45, .3g6 1.00 33 .48 F
ATOM 10309 O ASN 487 30.51δ 100.702 44, .575 1.00 33 .48 F
ATOM 10310 N CYS 488 31.324 101.790 46, .359 1.00 33 .48 F
ATOM 10311 CA CYS 488 30.167 102.677 46, .4δ5 1.00 33 .48 F
ATOM 10312 CB CYS 488 30.017 103.141 47, .928 1.00 33, .48 F
ATOM 10313 SG CYS 48δ 29.546 101.822 49. ,044 1.00 33 .48 F
ATOM 10314 C CYS 488 30.290 103.890 45, ,573 1.00 33 .48 F
ATOM 10315 O CYS 488 31.359 104.474 45. ,448 1.00 33, .48 F
ATOM 10316 N LEU 489 29.ig3 104.276 44, ,934 1.00 33, .48 F
ATOM 10317 CA LEU 489 2g.225 105.433 44, ,040 1.00 33, .48 F
ATOM 10318 CB LEU 489 2δ.δ06 104.99δ 42. ,638 1.00 33, .48 F
ATOM 10319 CG LEU 489 29.δ04 103.996 42. ,046 1.00 33, .48 F
ATOM 10320 CDl LEU 489 29.ogι 102. g57 41. ,219 1.00 33, .48 F
ATOM 10321 CD2 LEU 489 30.819 104.740 41. ,209 1.00 33, .48 F
ATOM 10322 C LEU 489 28.365 106. sgs 44. .543 1.00 33, .48 F
ATOM 10323 O LEU 489 27.410 106.3g4 45. .282 1.00 33, .48 F
ATOM 10324 N VAL 490 28.736 107.813 44, ,162 1.00 33 .48 F
ATOM 10325 CA VAL 490 2δ.025 iog.020 44. ,587 1.00 33, .48 F
ATOM 10326 CB VAL 490 2δ.9δg 110.110 45, ,064 1.00 33, .48 F
ATOM 10327 CGl VAL 490 2δ.204 111.227 45, ,70δ 1.00 33 .48 F
ATOM 10328 CG2 VAL 490 30.01δ 10g.540 46. ,020 1.00 33, .48 F
ATOM 10329 C VAL 490 27.224 109.617 43. ,445 1.00 33, .48 F
ATOM 10330 O VAL 490 27.710 109.719 42, ,323 1.00 33, .48 F
ATOM 10331 N GLY 491 26.000 110.032 43. ,722 1.00 33, .48 F
ATOM 10332 CA GLY 491 25.ig5 110.593 42. ,659 1.00 33, ,48 F
ATOM 10333 C GLY 491 24.413 111.827 43, ,04δ 1.00 33, .48 F
ATOM 10334 O GLY 491 24.δig 112.582 43. ,93g 1.00 33, .48 F ATOM 10335 N GLU 492 23.283 112.020 42.375 1.00 33.4δ F
ATOM 10336 CA GLU 492 22.416 113.16δ 42.60δ 1.00 33.4δ F
ATOM 10337 CB GLU 492 21.007 112.867 42.101 1.00 33.48 F
ATOM 1033δ CG GLU 492 20.722 113.342 40.691 1.00 33.48 F
ATOM 10339 CD GLU 492 19.442 114.160 40.637 1.00 33.48 F
ATOM 10340 OEl GLU 492 19.508 115.367 40.264 1.00 33.48 F
ATOM 10341 OE2 GLU 492 18.375 113.588 40.9δ4 1.00 33.48 F
ATOM 10342 C GLU 492 22.33δ 113.598 44.063 1.00 33.48 F
ATOM 10343 O GLU 492 21.968 112.820 44.g37 1.00 33.48 F
ATOM 10344 N ASN 493 22.675 114.851 44.317 1.00 33.48 F
ATOM 10345 CA ASN 43 22.631 115.365 45.665 1.00 33.48 F
ATOM 10346 CB ASN 4g3 21.186 115.468 46.150 1.00 33.48 F
ATOM 10347 CG ASN 4g3 20.2g3 116.208 45.174 1.00 33.48 F
ATOM 1034δ ODl ASN 4g3 ig.774 115.612 44.226 1.00 33.48 F
ATOM 10349 ND2 ASN 4g3 20.113 117.516 45.3gθ 1.00 33.48 F
ATOM 10350 C ASN 4g3 23.408 114.497 46.645 1.00 33.48 F
ATOM 10351 O ASN 493 23.027 114.401 47.δl5 1.00 33.48 F
ATOM 10352 N GLN 494 24.475 113.854 46.173 1.00 33.48 F
ATOM 10353 CA GLN 494 25.303 113.013 47.030 1.00 33.48 F
ATOM 10354 CB GLN 4g4 25.781 113.785 48.242 1.00 33.48 F
ATOM 10355 CG GLN 4g4 26.403 115.104 47.964 1.00 33.4δ F
ATOM 10356 CD GLN 4g4 27.016 115.649 49.207 1.00 33.4δ F
ATOM 10357 OEl GLN 4g4 26.363 115.700 50.256 1.00 33.4δ F
ATOM 1035δ NE2 GLN 4g4 28.278 116.053 49.120 1.00 33.48 F
ATOM 10359 C GLN 4g4 24.654 111.756 47.569 1.00 33.48 F
ATOM 10360 O GLN 4g4 24.831 111.433 48.742 1.00 33.4δ F
ATOM 10361 N VAL 45 23.8g6 111.051 46.744 1.00 33.4δ F
ATOM 10362 CA VAL 45 23.268 109.822 47.197 1.00 33.4δ F
ATOM 10363 CB VAL 4g5 22.014 109.470 46.360 1.00 33.4δ F
ATOM 10364 CGl VAL 4g5 22.360 109.3g7 44.δ91 1.00 33.4δ F
ATOM 10365 CG2 VAL 4g5 21.458 108.145 46.δl2 1.00 33.4δ F
ATOM 10366 C VAL 4g5 24.311 108.731 47.021 1.00 33.4δ F
ATOM 10367 O VAL 4g5 25.021 108.721 46.02δ 1.00 33.4δ F
ATOM 1036δ N ILE 4g6 24.426 107.82δ 47.gδ3 1.00 33.48 F
ATOM 10369 CA ILE 4gε 25.3gi 106.75δ 47.δ50 1.00 33.48 F
ATOM 10370 CB ILE 4g6 26.053 106.416 4g.206 1.00 33.4δ F
ATOM 10371 CG2 ILE 46 27.12g 105.349 49.015 1.00 33.4δ F
ATOM 10372 CGl ILE 46 26.6gg 107.663 49.80g 1.00 33.4δ F
ATOM 10373 CDl ILE 4g6 27.773 10δ.274 48.953 1.00 33.48 F
ATOM 10374 C ILE 4gε 24.671 105.535 47.335 1.00 33.48 F
ATOM 10375 0 ILE 4gε 23.547 105.288 47.71δ 1.00 33.4δ F
ATOM 10376 N LYS 4g7 25.311 104.778 46.456 1.00 33.4δ F
ATOM 10377 CA LYS 497 24.714 103.557 45.920 1.00 33.4δ F
ATOM 10378 CB LYS 497 24.234 103.778 44.4δδ 1.00 33.4δ F ATOM 1037g CG LYS 4g7 23.101 104.752 44..381 1.00 33,.48 F
ATOM 10380 CD LYS 4g7 22.615 104.904 42. , 48 1.00 33, .48 F
ATOM 10381 CE LYS 4g7 21.330 105.721 42. ,899 1.00 33, .48 F
ATOM 103δ2 NZ LYS 4g7 20.g56 106.07δ 41. ,513 1.00 33, .48 F
ATOM 10383 C LYS 4g7 25.6g4 102.3δ4 45. .947 1.00 33, .48 F
ATOM 10384 O LYS 4g7 26.g04 102.559 45. ,8og 1.00 33, .48 F
ATOM 10385 N VAL 4gδ 25.161 101.184 46. .109 1.00 33, ,48 F
ATOM 10386 CA VAL 498 25.983 9g.ggι 46. ,156 1.00 33, ,48 F
ATOM 10387 CB VAL 498 25.245 g8.δ70 46. ,925 1.00 33, .48 F
ATOM 1038δ CGl VAL 498 26.102 g7.63g 47. ,009 1.00 33, .48 F
ATOM 103δ9 CG2 VAL 498 24.906 gg.344 48. ,309 1.00 33, .48 F
ATOM 10390 C VAL 498 26.351 gg.siδ 44. ,744 1.00 33, .48 F
ATOM 10391 O VAL 498 25.574 gg.εgi 43, .818 1.00 33 .48 F
ATOM 103g2 N SER 499 27.546 gδ.g30 44. ,59g 1.00 33, .48 F
ATOM 103g3 CA SER 49g 2δ.044 gδ.425 43. ,315 1.00 33, .48 F
ATOM 103g4 CB SER 4gg 29.077 gg.390 42. .730 1.00 33 .48 F
ATOM 103g5 OG SER 499 29.60δ 98.gθδ 41, .502 1.00 33 .48 F
ATOM 103g6 C SER 49g 2δ.646 g7.012 43, .342 1.00 33, .48 F
ATOM 103g7 O SER 4gg 2g.l56 g6.550 44, ,357 1.00 33, .48 F
ATOM i03g N ASP 500 28.56g g6.346 42, .194 1.00 33 .48 F
ATOM i03g CA ASP 500 29.074 g4.ggo 41, ,gg9 1.00 33, .48 F
ATOM 10400 CB ASP 500 30.478 g4.882 42, .550 1.00 33, .48 F
ATOM 10401 CG ASP 500 31.455 g5.6g2 41, .738 1.00 33, .48 F
ATOM 10402 ODl ASP 500 31.495 g6.929 41, .918 1.00 33 .48 F
ATOM 10403 OD2 ASP 500 32.161 gs.ogg 40. .890 1.00 33, .48 F
ATOM 10404 C ASP 500 28.1δ5 g3.8δ2 42. .549 1.00 33, .48 F
ATOM 10405 O ASP 500 27.451 93.232 41. .786 1.00 33, .48 F
ATOM 10406 N PHE 501 2δ.265 93.651 43. ,δ56 1.00 33, .48 F
ATOM 10407 CA PHE 501 27.425 92.650 44. .506 1.00 33, .48 F
ATOM 10408 CB PHE 501 26.294 93.363 45. .237 1.00 33, .48 F
ATOM 1040g CG PHE 501 25.461 94.230 44, .340 1.00 33 .48 F
ATOM 10410 CDl PHE 501 24.396 93.6g4 43, .627 1.00 33, .48 F
ATOM 10411 CD2 PHE 501 25.783 g5.566 44, .158 1.00 33 .48 F
ATOM 10412 CEl PHE 501 23.670 g4.476 42, ,745 1.00 33 .48 F
ATOM 10413 CE2 PHE 501 25.065 g6.351 43, ,282 1.00 33 .48 F
ATOM 10414 CZ PHE 501 24.006 gs.δog 42. ,571 1.00 33 .48 F
ATOM 10415 C PHE 501 26.δ26 91.649 43. ,526 1.00 33 .48 F
ATOM 10416 O PHE 501 27.505 90.74δ 43. ,04δ 1.00 33 .48 F
ATOM 10417 N PHE 520 43.599 91.984 47. ,240 1.00 33 .48 F
ATOM 10418 CA PHE 520 42.96δ 91.139 48. ,256 1.00 33 .48 F
ATOM 10419 CB PHE 520 43.9δ2 go.147 48. ,δ27 1.00 33 .48 F
ATOM 10420 CG PHE 520 44.444 8g.l27 47. ,δ32 1.00 33 .48 F
ATOM 10421 CDl PHE 520 43.5δ2 88.130 47. ,3g6 1.00 33, .48 F
ATOM 10422 CD2 PHE 520 45.725 8g.lδ6 47. ,301 1.00 33, .48 F ATOM 10423 CEl PHE 520 43.991 87.216 46.449 1.0033.,48 F
ATOM 10424 CE2 PHE 520 46.132 δδ.275 46. 357 1.00 33. ,48 F
ATOM 10425 CZ PHE 520 45.266 87.291 45. 931 1.00 33. ,48 F
ATOM 10426 C PHE 520 42.407 92.018 49. 365 1.00 33, .48 F
ATOM 10427 0 PHE 520 43.134 92.771 50. 010 1.00 33, .48 F
ATOM 1042δ N PRO 521 41.100 91.920 49. 610 1.00 33, .48 F
ATOM 1042g CD PRO 521 40.0δ7 91.295 48. 744 1.00 33, .48 F
ATOM 10430 CA PRO 521 40.46δ 92.733 50. ,640 1.00 33, .48 F
ATOM 10431 CB PRO 521 39.194 g3.165 49. ,957 1.00 33, .48 F
ATOM 10432 CG PRO 521 3δ.788 91.884 49. ,271 1.00 33, .48 F
ATOM 10433 C PRO 521 40.177 g2.042 51. ,963 1.00 33, .48 F
ATOM 10434 0 PRO 521 3g.019 91.991 52. ,385 1.00 33, .48 F
ATOM 10435 N VAL 522 41.197 91.517 52. ,632 1.00 33, .48 F
ATOM 10436 CA VAL 522 40.926 90.871 53. ,902 1.00 33, .48 F
ATOM 10437 CB VAL 522 42.121 90.005 54. ,404 1.00 33, .48 F
ATOM 1043δ CGl VAL 522 42.δ94 89.467 53. ,230 1.00 33, .48 F
ATOM 1043g CG2 VAL 522 42.gg7 go.7g4 55, ,338 1.00 33, .48 F
ATOM 10440 C VAL 522 40.631 gι.g84 54, ,8δ2 1.00 33, .48 F
ATOM 10441 0 VAL 522 40.045 gi.754 55, ,927 1.00 33, .48 F
ATOM 10442 N LYS 523 41.023 g3.201 54, ,525 1.00 33, ,48 F
ATOM 10443 CA LYS 523 40.7δ0 g4.355 55, ,393 1.00 33, .48 F
ATOM 10444 CB LYS 523 41.476 5.610 54, .837 1.00 33 .48 F
ATOM 10445 CG LYS 523 42.g60 g5.674 55, .165 1.00 33 .48 F
ATOM 10446 CD LYS 523 43.5g7 gε.gδδ 54, .744 1.00 33 .48 F
ATOM 10447 CE LYS 523 45.0g6 g6.945 55, .021 1.00 33 .48 F
ATOM 1044δ NZ LYS 523 45.δlδ 98.ιgg 54, .647 1.00 33 .48 F
ATOM 1044g C LYS 523 3g.2δδ g4.650 55, .622 1.00 33 .48 F
ATOM 10450 0 LYS 523 3δ.g07 g5.197 56, .651 1.00 33 .48 F
ATOM 10451 N TRP 524 38.45g 94.280 54, ,653 1.00 33 .48 F
ATOM 10452 CA TRP 524 37.020 94.470 54, ,738 1.00 33 .48 F
ATOM 10453 CB TRP 524 36.4g5 94.981 53, .401 1.00 33 .48 F
ATOM 10454 CG TRP 524 36.826 96.405 53, .161 1.00 33 .48 F
ATOM 10455 CD2 TRP 524 38.001 96.921 52, .533 1.00 33 .48 F
ATOM 10456 CE2 TRP 524 37.gi8 9δ.312 52, ,5δ2 1.00 33 .48 F
ATOM 10457 CE3 TRP 524 3g.H5 96.339 51, .g37 1.00 33 .48 F
ATOM 1045δ CDl TRP 524 36.101 97.476 53, .54g 1.00 33 .48 F
ATOM 1045g NEl TRP 524 36.743 98.628 53, .206 1.00 33 .48 F
ATOM 10460 CZ2 TRP 524 38.g05 9g.l31 52, .060 1.00 33 .48 F
ATOM 10461 CZ3 TRP 524 40.08g g7.155 51, .419 1.00 33 .48 F
ATOM 10462 CH2 TRP 524 39.981 9δ.529 51, .4δ3 1.00 33 .48 F
ATOM 10463 C TRP 524 36.357 3.144 55, .0δ6 1.00 33 .48 F
ATOM 10464 0 TRP 524 35.191 g3.ogo 55, .433 1.00 33 .48 F
ATOM 10465 N ALA 525 37.122 g2.072 54, .9g3 1.00 33 .48 F
ATOM 10466 CA ALA 525 36.615 gθ.747 55, .27g 1.00 33 .48 F ATOM 10467 CB ALA 525 37.407 89.,731 54.,491 1.00 33.48 F
ATOM 10468 c ALA 525 36.666 90. ,407 56. ,760 1.00 33.48 F
ATOM 1046g 0 ALA 525 37.601 90. ,775 57. 459 1.00 33.48 F
ATOM 10470 N SER 526 35.656 89. ,691 57. ,231 1.00 33.48 F
ATOM 10471 CA SER 526 35.594 89. ,291 58. ,622 1.00 33.4δ F
ATOM 10472 CB SER 526 34.149 89. ,083 59. ,046 1.00 33.48 F
ATOM 10473 OG SER 526 33.638 87. ,892 58. .481 1.00 33.48 F
ATOM 10474 C SER 526 36.349 87. ,977 58. ,793 1.00 33.48 F
ATOM 10475 O SER 526 36.δδ5 87. ,404 57. ,829 1.00 33.48 F
ATOM 10476 N PRO 527 36.396 87. .471 60. ,031 1.00 33.48 F
ATOM 10477 CD PRO 527 36.033 δδ. .130 61. ,293 1.00 33.48 F
ATOM 1047δ CA PRO 527 37.091 86. .222 60. ,297 1.00 33.48 F
ATOM 10479 CB PRO 527 36.853 86. .024 61. ,775 1.00 33.48 F
ATOM 10480 CG PRO 527 36.915 87. .415 62. ,274 1.00 33.48 F
ATOM 10481 C PRO 527 36.636 85, .046 59. ,454 1.00 33.48 F
ATOM 10482 O PRO 527 37.440 84, .500 58. .717 1.00 33.48 F
ATOM 10483 N GLU 528 35.367 84, .653 59. .528 1.00 33.48 F
ATOM 10484 CA GLU 528 34.935 83, .510 58. .728 1.00 33.48 F
ATOM 10485 CB GLU 52δ 33.420 83, .368 58. .669 1.00 33.48 F
ATOM 10486 CG GLU 528 32.685 83, .729 59. .906 1.00 33.4δ F
ATOM 10487 CD GLU 528 32.331 85, .181 59. ,92g 1.00 33.48 F
ATOM 10488 OEl GLU 528 33.048 85, ,935 60. ,610 1.00 33.48 F
ATOM 10489 OE2 GLU 528 31.348 85, ,566 59. ,254 1.00 33.48 F
ATOM 10490 C GLU 528 35.428 83, ,593 57. ,2g2 1.00 33.48 F
ATOM 10491 0 GLU 528 36.062 82, .663 56. ,7g3 1.00 33.48 F
ATOM 10492 N VAL 52g 35.159 84, .704 56, ,612 1.00 33.48 F
ATOM 10493 CA VAL 52g 35.588 84, .769 55, .228 1.00 33.48 F
ATOM 10494 CB VAL 52g 34.954 85, .944 54, ,43g 1.00 33.48 F
ATOM 104g5 CGl VAL 52 33.455 85, .888 54, .546 1.00 33.48 F
ATOM 104g6 CG2 VAL 529 35.48δ 87, .248 54, ,g25 1.00 33.48 F
ATOM 104g7 C VAL 529 37.0δ3 84, .803 55. ,022 1.00 33.48 F
ATOM 104g8 0 VAL 529 37.540 84. .380 53. ,g73 1.00 33.48 F
ATOM io4gg N PHE 530 37.δ71 85. .294 55, ,973 1.00 33.48 F
ATOM 10500 CA PHE 530 39.303 85, .274 55, ,698 1.00 33.48 F
ATOM 10501 CB PHE 530 40.025 86, .534 56, ,228 1.00 33.4δ F
ATOM 10502 CG PHE 530 40.161 86, ,615 57, ,728 1.00 33.4δ F
ATOM 10503 CDl PHE 530 39.g56 87, ,822 58. ,377 1.00 33.4δ F
ATOM 10504 CD2 PHE 530 40.57g 85, ,535 58. ,479 1.00 33.4δ F
ATOM 10505 CEl PHE 530 40.174 87, .948 59. ,740 1.00 33.48 F
ATOM 10506 CE2 PHE 530 40.7g5 85, .658 59. ,841 1.00 33.48 F
ATOM 10507 CZ PHE 530 40.595 86, .864 60. ,469 1.00 33.48 F
ATOM 10508 C PHE 530 39.925 83, ,99g 56. ,227 1.00 33.48 F
ATOM losog 0 PHE 530 40.942 83, .530 55. ,726 1.00 33.48 F
ATOM 10510 N SER 531 39.27δ 83, .405 57. ,213 1.00 33.48 F ATOM 10511 CA SER 531 39..790 82,■ lδl 57.795 1.00 33.4δ F
ATOM 10512 CB SER 531 39. .573 82, .199 59. .307 1.00 33 .4δ F
ATOM 10513 OG SER 531 38. ,192 82, .305 59. ,613 1.00 33 .4δ F
ATOM 10514 C SER 531 39. ,162 δO, .923 57. ,206 1.00 33 .4δ F
ATOM 10515 O SER 531 39, .793 79, ,δ71 57, ,208 1.00 33 .4δ F
ATOM 10516 N PHE 532 37, .928 δl, .030 56. ,709 1.00 33 .4δ F
ATOM 10517 CA PHE 532 37, .222 79, .880 56. ,125 1.00 33 .4δ F
ATOM 10518 CB PHE 532 36. .295 79, ,24g 57. ,159 1.00 33, .4δ F
ATOM 10519 CG PHE 532 36, ,g26 79, .osg 5δ. ,4go 1.00 33 .4δ F
ATOM 10520 CDl PHE 532 38, .011 78, .247 5δ. .652 1.00 3 .48 F
ATOM 10521 CD2 PHE 532 36, ,4g9 79, .846 59. .561 1.00 33, .48 F
ATOM 10522 CEl PHE 532 38, .671 78, .167 59. ,δ62 1.00 33 .48 F
ATOM 10523 CE2 PHE 532 37, ,152 79, .774 60. ,7δ0 1.00 33, .48 F
ATOM 10524 CZ PHE 532 38. ,243 78, ,g34 60. ,g3i 1.00 33, .4δ F
ATOM 10525 C PHE 532 36. .396 80, .235 54, ,go2 1.00 33 .4δ F
ATOM 10526 O PHE 532 35. .472 79, .507 54. ,54g 1.00 33, .4δ F
ATOM 10527 N SER 533 36. .706 81, .363 54. .274 1.00 33, .4δ F
ATOM 1052δ CA SER 533 35. .985 81, .787 53. ,0δ5 1.00 33, .48 F
ATOM 10529 CB SER 533 36. .sgg δl, .103 51. ,δ6g 1.00 33, .48 F
ATOM 10530 OG SER 533 36, .121 δl, .671 50, .670 1.00 33 .4δ F
ATOM 10531 C SER 533 34, ,4δg δl, .464 53. ,ιgι 1.00 33, .4δ F
ATOM 10532 O SER 533 33, ,δ72 80, , 7 52. .247 1.00 33 .4δ F
ATOM 10533 N ARG 534 33, ,g22 81. .765 54. .355 1.00 33, .48 F
ATOM 10534 CA ARG 534 32, .5ig 81, .510 54. ,64g 1.00 33 .48 F
ATOM 10535 CB ARG 534 32, .435 80, .g47 56, .064 1.00 33 .48 F
ATOM 10536 CG ARG 534 31, .202 δO, ,13δ 56. .376 1.00 33, .48 F
ATOM 10537 CD ARG 534 31, .463 79, .352 57. .641 1.00 33 .4δ F
ATOM 1053δ NE ARG 534 32. ,6δ2 78, ,548 57. ,504 1.00 33, .48 F
ATOM 10539 CZ ARG 534 33. ,3go 78, .048 58, ,5ig 1.00 33, .48 F
ATOM 10540 NHl ARG 534 33. .024 78, .250 59, ,7δl 1.00 33 .4δ F
ATOM 10541 NH2 ARG 534 34. ,4δ7 77 , .348 58. ,26δ 1.00 33, ,4δ F
ATOM 10542 C ARG 534 31. .605 82. .754 54. ,4gg 1.00 33, .48 F
ATOM 10543 O ARG 534 31. ,052 83. .278 55. ,472 1.00 33, .48 F
ATOM 10544 N TYR 535 31. ,442 83. .204 53. ,262 1.00 33, .4δ F
ATOM 10545 CA TYR 535 30. ,626 δ4. .364 52. ,g47 1.00 33, .4δ F
ATOM 10546 CB TYR 535 30. ,753 δ4, ,654 51. ,453 1.00 33, .4δ F
ATOM 10547 CG TYR 535 32. ,085 δ5, ,268 51. ,105 1.00 33, .4δ F
ATOM 1054δ CDl TYR 535 32. ,341 δ6, ,5g3 51. ,4og 1.00 33, ,4δ F
ATOM 1054g CEl TYR 535 33. ,572 87 , ,158 51. ,176 1.00 33, .48 F
ATOM 10550 CD2 TYR 535 33. ,111 δ4, ,514 50, ,544 1.00 33, .48 F
ATOM 10551 CE2 TYR 535 34. ,366 δ5. ,075 50. ,301 1.00 33, .48 F
ATOM 10552 CZ TYR 535 34. ,586 86. ,405 50. ,626 1.00 33, .48 F
ATOM 10553 OH TYR 535 35. ,807 87. ,018 50. ,425 1.00 33, .48 F
ATOM 10554 C TYR 535 29. ,162 δ4. ,23δ 53. ,350 1.00 33, .48 F ATOM 10555 O TYR 535 28. ,546 δ3.191 53. ,190 1.00 33.48 F
ATOM 10556 N SER 536 28. ,610 δ5.322 53. ,879 1.00 33.48 F
ATOM 10557 CA SER 536 27. ,216 85.346 54. ,310 1.00 33.48 F
ATOM 10558 CB SER 536 27. ,070 84.764 55. ,693 1.00 33.4δ F
ATOM 10559 OG SER 536 27. ,091 85.δ29 56. ,623 1.00 33.4δ F
ATOM 10560 C SER 536 26. ,744 δ6.7δ5 54. ,395 1.00 33.4δ F
ATOM 10561 O SER 536 27. ,492 δ7.70g 54. ,103 1.00 33.4δ F
ATOM 10562 N SER 537 25. ,502 δ6.gδ4 54. ,809 1.00 33.4δ F
ATOM 10563 CA SER 537 25, ,028 δδ.34g 54. ,931 1.00 33.48 F
ATOM 10564 CB SER 537 23. ,491 δδ.415 54. ,971 1.00 33.48 F
ATOM 10565 OG SER 537 22. ,g67 δδ.g70 53. ,75g 1.00 33.4δ F
ATOM 10566 C SER 537 25. .630 δδ.g66 56. .188 1.00 33.4δ F
ATOM 10567 O SER 537 25. .910 go.163 56. ,2og 1.00 33.48 F
ATOM 10568 N LYS 538 25. ,846 δδ.155 57. ,224 1.00 33.48 F
ATOM 10569 CA LYS 538 26. ,425 δ8.671 58. .455 1.00 33.48 F
ATOM 10570 CB LYS 538 26. ,29g 87.671 59. ,5g6 1.00 33.48 F
ATOM 10571 CG LYS 538 24. ,927 87.693 60. .248 1.00 33.48 F
ATOM 10572 CD LYS 538 24, ,517 89.107 60. .666 1.00 33.48 F
ATOM 10573 CE LYS 53δ 23, ,117 89.136 61. ,27g 1.00 33.48 F
ATOM 10574 NZ LYS 53δ 23, .004 88.202 62. .425 1.00 33.48 F
ATOM 10575 C LYS 538 27, .873 89.043 58. .233 1.00 33.4δ F
ATOM 10576 O LYS 538 28, .517 89.661 59. .087 1.00 33.4δ F
ATOM 10577 N SER 53 28, .395 88.654 57. ,07g 1.00 33.4δ F
ATOM 10578 CA SER 53g 29, .749 89.030 56. .744 1.00 33.4δ F
ATOM 10579 CB SER 53g 30, .264 88.232 55. ,557 1.00 33.4δ F
ATOM 10580 OG SER 53g 30, .613 86.923 55. .960 1.00 33.4δ F
ATOM 10581 C SER 53g 29, .554 90.470 56. .347 1.00 33.4δ F
ATOM 10582 O SER 539 30, .047 91.381 57. .005 1.00 33.4δ F
ATOM 10583 N ASP 540 28, ,790 90.661 55. .277 1.00 33.48 F
ATOM 10584 CA ASP 540 28, ,489 91.981 54, .775 1.00 33.48 F
ATOM 10585 CB ASP 540 27, ,204 91.942 53, .967 1.00 33.4δ F
ATOM 105δ6 CG ASP 540 27, .376 91.231 52, .642 1.00 33.48 F
ATOM 105δ7 ODl ASP 540 2δ, .162 90.261 52, ,606 1.00 33.48 F
ATOM 10588 OD2 ASP 540 26, .728 91.626 51, ,640 1.00 33.48 F
ATOM 10589 C ASP 540 28, .354 92.g5g 55, ,923 1.00 33.48 F
ATOM 10590 O ASP 540 28, .809 g4.087 55. ,829 1.00 33.48 F
ATOM 10591 N VAL 541 27, .727 g2.544 57. ,015 1.00 33.48 F
ATOM 10592 CA VAL 541 27, .597 g3.447 58. .143 1.00 33.48 F
ATOM 10593 CB VAL 541 27, .030 g2.742 59. .375 1.00 33.48 F
ATOM 10594 CGl VAL 541 27, .060 g3.672 60, .567 1.00 33.48 F
ATOM 10595 CG2 VAL 541 25, .625 g2.304 59, .104 1.00 33.48 F
ATOM 10596 C VAL 541 28, ,gδ4 93.967 58, ,470 1.00 33.48 F
ATOM 10597 O VAL 541 29, .212 g5.176 58. ,529 1.00 33.48 F
ATOM 1059δ N TRP 542 29, ,gi6 g3.040 58, .658 1.00 33.48 F ATOM 1059g CA TRP 542 31..290 g3,,404 58.,9δ0 1.0033,.48 F
ATOM 106OO CB TRP 542 32, .203 g2, .165 58. ,gδ7 1.00 33 .48 F
ATOM 106O1 CG TRP 542 33, ,602 g2, .441 59. .465 1.00 33 .48 F
ATOM 106O2 CD2 TRP 542 34. ,190 g2, .019 60. ,700 1.00 33, .48 F
ATOM 106O3 CE2 TRP 542 35. ,493 g2, .539 60. ,742 1.00 33 .48 F
ATOM 106O4 CE3 TRP 542 33, .741 91, .256 61. .771 1.00 33 .48 F
ATOM 106O5 CDl TRP 542 34, ,553 93, .175 58. ,δ27 1.00 33, .48 F
ATOM 106O6 NEl TRP 542 35, .693 g3, .243 59. ,5δ6 1.00 33 .48 F
ATOM 106O7 CZ2 TRP 542 36, .348 92. .319 61. ,812 1.00 33, .48 F
ATOM 106O8 CZ3 TRP 542 34, .597 91. .040 62. ,830 1.00 33 .48 F
ATOM 106θg CH2 TRP 542 35, .880 91. .568 62. ,δ43 1.00 33 .48 F
ATOM 10610 C TRP 542 31. .778 94, .418 57. ,g67 1.00 33, .48 F
ATOM 10611 O TRP 542 32, .175 95, .510 58. ,33g 1.00 33, .48 F
ATOM 10612 N SER 543 31, .735 94. .077 56, ,6δ7 1.00 33 .48 F
ATOM 10613 CA SER 543 32, ,183 95, .014 55. ,676 1.00 33, .48 F
ATOM 10614 CB SER 543 31, .936 94, .457 54. ,2 2 1.00 33 .48 F
ATOM 10615 OG SER 543 32, ,696 93, .286 54, ,113 1.00 33, .48 F
ATOM 10616 C SER 543 31, ,476 96, .341 55. ,822 1.00 33, .48 F
ATOM 10617 O SER 543 32, .054 97, .381 55, ,538 1.00 33 .48 F
ATOM 10618 N PHE 544 30, .224 96, .313 56. ,270 1.00 33, .48 F
ATOM 10619 CA PHE 544 29, .470 97, .545 56. ,446 1.00 33 .48 F
ATOM 10620 CB PHE 544 28, .013 97. .259 56. .843 1.00 33 .48 F
ATOM 10621 CG PHE 544 27, .214 98. .507 57. ,178 1.00 33 .48 F
ATOM 10622 CDl PHE 544 26, .951 99. .458 56. .213 1.00 33 .48 F
ATOM 10623 CD2 PHE 544 26, ,7δ0 98. .745 58. .473 1.00 33, .48 F
ATOM 10624 CEl PHE 544 26, ,2δ2 100. ,613 56. ,534 1.00 33 .48 F
ATOM 10625 CE2 PHE 544 26, .115 99. .896 58. ,7δg 1.00 33 .48 F
ATOM 10626 CZ PHE 544 25. ,δ67 100. ,830 57. ,δ23 1.00 33, .48 F
ATOM 10627 C PHE 544 30. .151 98. ,352 57. ,530 1.00 33, .48 F
ATOM 10628 0 PHE 544 30. ,444 99. ,530 57. ,344 1.00 33, .48 F
ATOM 10629 N GLY 545 30. ,401 97. ,717 58. ,665 1.00 33, .48 F
ATOM 10630 CA GLY 545 31. ,057 98. ,412 59. ,750 1.00 33, .48 F
ATOM 10631 C GLY 545 32. ,359 99. ,020 59. ,273 1.00 33, .48 F
ATOM 10632 0 GLY 545 32. ,753 100. ,100 59. ,699 1.00 33, .48 F
ATOM 10633 N VAL 546 33. ,049 98. ,324 58. .381 1.00 33, .48 F
ATOM 10634 CA VAL 546 34. ,2g7 98. ,854 57. ,886 1.00 33, .48 F
ATOM 10635 CB VAL 546 35. ,067 97. ,824 57. ,043 1.00 33, .48 F
ATOM 10636 CGl VAL 546 36. ,415 98. ,389 56. ,648 1.00 33 .48 F
ATOM 10637 CG2 VAL 546 35. ,247 96. ,55g 57. ,826 1.00 33, .48 F
ATOM 10638 C VAL 546 33. ,933 100. ,052 57. ,045 1.00 33, .48 F
ATOM 10639 0 VAL 546 34. ,510 101. ,114 57. ,217 1.00 33, .48 F
ATOM 1064O N LEU 547 32. ,963 99. ,884 56. ,148 1.00 33, .48 F
ATOM 10641 CA LEU 547 32. ,5og 100. ,986 55. ,305 1.00 33, .48 F
ATOM 10642 CB LEU 547 31. 246 100. 612 54. 524 1.00 33, .48 F ATOM 10643 CG LEU 547 30.,616101.,δ41 53.,855 1.0033,.48 F
ATOM 10644 CDl LEU 547 30. ,922 101. .868 52. ,387 1.00 33, .48 F
ATOM 10645 CD2 LEU 547 29. ,130 101. .823 54. ,075 1.00 33, .48 F
ATOM 10646 C LEU 547 32. ,213 102. .226 56. ,142 1.00 33, .48 F
ATOM 10647 O LEU 547 32. ,656 103, .312 55. ,δ05 1.00 33, .48 F
ATOM 1064δ N MET 548 31. ,453 102, ,06δ 57. ,220 1.00 33, .48 F
ATOM 1064g CA MET 548 31. ,145 103, .201 58. ,079 1.00 33, .48 F
ATOM 10650 CB MET 548 30. ,381 102, .754 sg. ,325 1.00 33, .48 F
ATOM 10651 CG MET 548 28. ,982 102, .224 59. ,0δ7 1.00 33, .48 F
ATOM 10652 SD MET 54δ 28. .203 101, .715 60. .626 1.00 33 .48 F
ATOM 10653 CE MET 54δ 27. .945 103, .246 61. .355 1.00 33, .48 F
ATOM 10654 C MET 548 32. .436 103, .δδ6 58. ,513 1.00 33, .48 F
ATOM 10655 O MET 548 32, ,49g 105, .108 58. ,5g6 1.00 33, .48 F
ATOM 10656 N TRP 549 33. .461 103, .082 58. ,7g2 1.00 33, .48 F
ATOM 10657 CA TRP 54g 34, .772 103, .568 59. ,221 1.00 33 .48 F
ATOM 1065δ CB TRP 54g 35. .687 102, .373 59. .558 1.00 33 .48 F
ATOM 10659 CG TRP 549 36. .913 102, .740 60. ,33δ 1.00 33, .48 F
ATOM 10660 CD2 TRP 549 38. .157 103, .194 59, .807 1.00 33, .48 F
ATOM 10661 CE2 TRP 549 38. .965 103, .562 60, .s s 1.00 33, .48 F
ATOM 10662 CE3 TRP 549 38. ,666 103, .332 58, ,512 1.00 33, .48 F
ATOM 10663 CDl TRP 549 37, .019 102, .831 61, .686 1.00 33, .48 F
ATOM 10664 NEl TRP 549 38, ,24δ 103, .329 62, .034 1.00 33, .48 F
ATOM 10665 CZ2 TRP 549 40, .245 104, .062 60, ,734 1.00 33, .48 F
ATOM 10666 CZ3 TRP 549 39, .939 103, .831 58. ,353 1.00 33, .48 F
ATOM 10667 CH2 TRP 549 40, .715 104, .192 59. ,458 1.00 33, .48 F
ATOM 1066δ C TRP 54g 35, .413 104, .414 58. .117 1.00 33 .48 F
ATOM 10669 0 TRP 54 35, .916 105, .509 58, ,36δ 1.00 33 .48 F
ATOM 10670 N GLU 550 35, .396 103, .903 56, ,8 3 1.00 33 .48 F
ATOM 10671 CA GLU 550 35, ,9δ0 104, .638 55, ,78δ 1.00 33 .48 F
ATOM 10672 CB GLU 550 35, .881 103, ,83δ 54, ,4g7 1.00 33, .48 F
ATOM 10673 CG GLU 550 36, .496 102, .46g 54, .568 1.00 33 .48 F
ATOM 10674 CD GLU 550 36, .696 101, .δ56 53, .201 1.00 33 .48 F
ATOM 10675 OEl GLU 550 37, .610 102, ,2g5 52, .477 1.00 33 .48 F
ATOM 10676 OE2 GLU 550 35, .936 100, ,g40 52, .835 1.00 33 .48 F
ATOM 10677 C GLU 550 35, .266 105, ,g70 55. ,617 1.00 33, .48 F
ATOM 10678 0 GLU 550 35, .843 106, ,g42 55. .139 1.00 33, .48 F
ATOM 10679 N VAL 551 34, .000 106, .008 56. .013 1.00 33 .48 F
ATOM 10680 CA VAL 551 33, .201 107, .215 55, .894 1.00 33 .48 F
ATOM 10681 CB VAL 551 31, .694 106, ,88δ 55. ,928 1.00 33, .48 F
ATOM 10682 CGl VAL 551 30, .922 108, .ogo 56. ,368 1.00 33, .48 F
ATOM 10683 CG2 VAL 551 31. ,215 106, .488 54. ,551 1.00 33, .48 F
ATOM 10684 C VAL 551 33, .540 lOδ, .223 56. ,990 1.00 33, .48 F
ATOM 10685 0 VAL 551 33, .ggs 109, .333 56. ,700 1.00 33, .48 F
ATOM 10686 N PHE 552 33, .342 107, .845 58. ,246 1.00 33, .48 F ATOM 10687 CA PHE 552 33.631 108.757 5g.340 1.00 33.48 F
ATOM 10688 CB PHE 552 33.061 lθδ.193 60.638 1.00 33.48 F
ATOM 10689 CG PHE 552 31.608 lOδ . sog 60.822 1.00 33.48 F
ATOM 10690 CDl PHE 552 31.207 ιog.7g3 61.133 1.00 33.48 F
ATOM 10691 CD2 PHE 552 30.642 107.551 60.617 1.00 33.48 F
ATOM 10692 CEl PHE 552 29.8gi 110.104 61.228 1.00 33.48 F
ATOM 10693 CE2 PHE 552 2g.321107. δ65 60.711 1.00 33.48 F
ATOM 10694 CZ PHE 552 28.949 10g.137 61.015 1.00 33.48 F
ATOM 10695 C PHE 552 35.097 10g.144 5 .4g7 1.00 33.48 F
ATOM 10696 0 PHE 552 35.423 110.066 60.235 1.00 33.48 F
ATOM 10697 N SER 553 35. 7g ιoδ.44g 58.7g2 1.00 33.48 F
ATOM 10698 CA SER 553 37.407 10δ.760 5δ.841 1.00 33.48 F
ATOM 10699 CB SER 553 3δ.237 107.4δ7 5δ.773 1.00 33.48 F
ATOM 10700 OG SER 553 3δ.l67 106. 26 57.4δO 1.00 33.48 F
ATOM 10701 C SER 553 37.67110g.5δ3 57.5g6 1.00 33.48 F
ATOM 10702 0 SER 553 3δ.771110.058 57.34g 1.00 33.48 F
ATOM 10703 N GLU 554 36.621 iog.722 56.804 1.00 33.48 F
ATOM 10704 CA GLU 554 36.667 110.465 55.568 1.00 33.48 F
ATOM 10705 CB GLU 554 36.δl7 111.950 55.866 1.00 33.48 F
ATOM 10706 CG GLU 554 35.467 112.596 56.082 1.00 33.48 F
ATOM 10707 CD GLU 554 35.552 113.995 56.643 1.00 33.48 F
ATOM 10708 OEl GLU 554 36.503 114.737 56.286 1.00 33.48 F
ATOM 1O709 0E2 GLU 554 34.650 114.360 57.434 1.00 33.48 F
ATOM 1O710 C GLU 554 37.705 110.002 54.568 1.00 33.48 F
ATOM 10711 0 GLU 554 3δ.546 110.774 54.127 1.00 33.48 F
ATOM 10712 N GLY 555 37.635 10δ.724 54.222 1.00 33.48 F
ATOM 10713 CA GLY 555 38.526108.180 53.2ig 1.00 33.4δ F
ATOM 10714 C GLY 555 3g.902 107.663 53.572 1.00 33.48 F
ATOM 10715 0 GLY 555 40.683 107.355 52.667 1.00 33.48 F
ATOM 10716 N LYS 556 40.221 107.560 54.δ55 1.00 33.48 F
ATOM 10717 CA LYS 556 41.536 107.052 55.217 1.00 33.48 F
ATOM 10718 CB LYS 556 41.869 107.386 56.677 1.00 33.48 F
ATOM 107ig CG LYS 556 42.435 108.800 56.δ46 1.00 33.48 F
ATOM 1O720 CD LYS 556 42.869 109.107 5δ.272 1.00 33.48 F
ATOM 10721 CE LYS 556 43.801110.341 5δ.311 1.00 33.48 F
ATOM 10722 NZ LYS 556 44.148 110.825 5g.712 1.00 33.48 F
ATOM 10723 C LYS 556 41.602 105.552 54.g65 1.00 33.48 F
ATOM 10724 0 LYS 556 40.591 104.925 54.634 1.00 33.48 F
ATOM 10725 N ILE 557 42.793 104.981 55.113 1.00 33.48 F
ATOM 10726 CA ILE 557 42.996 103.557 54.δ74 1.00 33.48 F
ATOM 10727 CB ILE 557 44.350 103.327 54.205 1.00 33.48 F
ATOM 10728 CG2 ILE 557 44.642 101.862 54.130 1.00 33.48 F
ATOM 10729 CGl ILE 557 44.348 103. 47 52.811 1.00 33.48 F
ATOM 10730 CDl ILE 557 45.655 103.773 52.062 1.00 33.48 F ATOM 10731 C ILE 557 42.,g20 102..683 56..124 1.0033.48 F
ATOM 10732 0 ILE 557 43, .620 102. ,919 57. .107 1.00 33, .48 F
ATOM 10733 N PRO 558 42. ,064 101. ,652 56. ,og6 1.00 33, .48 F
ATOM 10734 CD PRO 558 41, ,142 101. ,31δ 54. .gg9 1.00 33, .48 F
ATOM 10735 CA PRO 558 41. ,889 100. ,729 57. ,222 1.00 33, .48 F
ATOM 10736 CB PRO 558 40. ,875 9g. ,723 56. .688 1.00 33, .48 F
ATOM 10737 CG PRO 558 40. ,085 100. ,522 55. .716 1.00 33, .48 F
ATOM 10738 C PRO 558 43. ,220 100. ,0δ2 57. .548 1.00 33, .48 F
ATOM 1073g 0 PRO 558 43. ,849 gg. ,509 56. ,679 1.00 33, .48 F
ATOM 10740 N TYR 559 43. ,634 100. ,157 58. ,δ06 1.00 33 .48 F
ATOM 10741 CA TYR 559 44, ,923 gg. ,604 59. ,210 1.00 33, .48 F
ATOM 10742 CB TYR 559 44. ,851 gδ. ,086 sg. ,339 1.00 33 .48 F
ATOM 10743 CG TYR 559 43. ,504 g7. ,529 sg. ,708 1.00 33, .48 F
ATOM 10744 CDl TYR 559 42. .560 7. ,249 58. .731 1.00 33 .48 F
ATOM 10745 CEl TYR 559 41, .353 g6. ,661 sg. .050 1.00 33, .48 F
ATOM 10746 CD2 TYR 559 43, .194 g7. .211 61. .024 1.00 33 .48 F
ATOM 10747 CE2 TYR 55g 41, .988 g6, ,622 61, .352 1.00 33, .48 F
ATOM 10748 CZ TYR ss 41, .074 g6. .351 60, .358 1.00 33 .48 F
ATOM 1074g OH TYR 55g 39, .867 gs, ,780 60, .663 1.00 33, .48 F
ATOM 10750 C TYR 559 45. .905 g9. ,9δ4 5δ, .090 1.00 33, .48 F
ATOM 10751 O TYR 559 46. .510 9g. ,122 57. .446 1.00 33, .48 F
ATOM 10752 N GLU 560 46. .049 101. ,2δ8 57. .867 1.00 33, .48 F
ATOM 10753 CA GLU 560 46. .893 101. ,7g3 56. ,79g 1.00 33, .48 F
ATOM 10754 CB GLU 560 47. .192 103. ,278 56. ,g78 1.00 33, .48 F
ATOM 10755 CG GLU 560 47, ,δ97 103. ,878 55, ,761 1.00 33, .48 F
ATOM 10756 CD GLU 560 48, ,480 105. ,263 56. ,033 1.00 33, .48 F
ATOM 10757 OEl GLU 560 49, .186 105. ,403 57, ,071 1.00 33 .48 F
ATOM 10758 OE2 GLU 560 48, .245 106. ,200 55. ,214 1.00 33, .48 F
ATOM 1075g C GLU 560 4δ, .igo 101. ,047 56, ,641 1.00 33 .48 F
ATOM 10760 O GLU 560 48, .347 100. ,256 55. ,712 1.00 33, .48 F
ATOM 10761 N ASN 561 49, .129 101, ,28 57. ,53g 1.00 33 .48 F
ATOM 10762 CA ASN 561 50, .406 100. ,625 57. ,435 1.00 33, .48 F
ATOM 10763 CB ASN 561 51, .503 101. ,570 57, ,g2δ 1.00 33 .48 F
ATOM 10764 CG ASN 561 51, .755 102. ,750 56. ,g52 1.00 33, .48 F
ATOM 10765 ODl ASN 561 50, .864 103. ,569 56. ,6δ0 1.00 33 .48 F
ATOM 10766 ND2 ASN 561 52, .978 102. .825 56. ,422 1.00 33 .48 F
ATOM 10767 C ASN 561 50, ,391 gg. ,307 58. ,ιgε 1.00 33, .48 F
ATOM 10768 o ASN 561 51, ,005 gg. ,169 sg. ,250 1.00 33, .48 F
ATOM 1076g N ARG 562 4g. ,660 gs. ,340 57. ,640 1.00 33, .48 F
ATOM 10770 CA ARG 562 4g. ,514 g6. ,993 58. ,ιg6 1.00 33, .48 F
ATOM 10771 CB ARG 562 48. ,387 gε. ,948 sg. ,217 1.00 33, .48 F
ATOM 10772 CG ARG 562 48, ,775 g7. ,385 60. ,604 1.00 33, .48 F
ATOM 10773 CD ARG 562 48. ,770 96. ,205 61. ,555 1.00 33, .48 F
ATOM 10774 NE ARG 562 50. ,020 96. ,163 62. ,2δg 1.00 33, .48 F ATOM 10775 CZ ARG 562 50.452 95. ,123 62, ,984 1.00 33.48 F
ATOM 10776 NHl ARG 562 49.734 94, ,011 63, ,067 1.00 33 .48 F
ATOM 10777 NH2 ARG 562 51.639 95. ,188 63, ,562 1.00 33 .48 F
ATOM 10778 C ARG 562 4g.ιg3 96, ,033 57, .063 1.00 33 .48 F
ATOM 10779 O ARG 562 48.4g6 96, ,388 56, .119 1.00 33 .48 F
ATOM 10780 N SER 563 49.692 94, ,812 57, .160 1.00 33 .48 F
ATOM 10781 CA SER 563 49.473 93, ,819 56, .116 1.00 33 .48 F
ATOM 10782 CB SER 563 50.683 92, ,898 56, .008 1.00 33 .48 F
ATOM 10783 OG SER 563 50.683 91, ,968 57, .080 1.00 33 .48 F
ATOM 10784 C SER 563 48.264 92, .986 56, .455 1.00 33 .48 F
ATOM 10785 O SER 563 47.877 92, .906 57, .612 1.00 33, .48 F
ATOM 10786 N ASN 564 47.6δ2 92, .343 55, .452 1.00 33, .48 F
ATOM 10787 CA ASN 564 46.517 91, .521 55, ,68δ 1.00 33, .48 F
ATOM 1078δ CB ASN 564 45.9g8 90, .971 54, ,3δ0 1.00 33. .48 F
ATOM 10789 CG ASN 564 45.776 92, .046 53. .353 1.00 33, .48 F
ATOM 10790 ODl ASN 564 45.313 93, .143 53. ,66δ 1.00 33, .48 F
ATOM 10791 ND2 ASN 564 46.0g3 91. .735 52. .106 1.00 33, .48 F
ATOM 10792 C ASN 564 46.877 90. .385 56. .621 1.00 33, .48 F
ATOM 10793 O ASN 564 46.015 89. ,785 57. .254 1.00 33, .48 F
ATOM 10794 N SER 565 48.164 90. ,083 56. ,7og 1.00 33, .48 F
ATOM 10795 CA SER 565 48.615 89. ,016 57. .586 1.00 33, .48 F
ATOM 10796 CB SER 565 50.065 88. ,692 57. ,2gg 1.00 33, .48 F
ATOM 107g7 OG SER 565 50.284 88. ,682 55. ,go4 1.00 33, .48 F
ATOM 107g8 C SER 565 48.474 89, ,594 58. .970 1.00 33, .48 F
ATOM io7gg O SER 565 47.g48 88. ,955 59. ,87δ 1.00 33, .48 F
ATOM lOδOO N GLU 566 48.g30 90, ,831 59. .112 1.00 33, .48 F
ATOM loδoi CA GLU 566 4δ.δ46 91, ,531 60. .386 1.00 33, .48 F
ATOM 10δ02 CB GLU 566 4g.702 92. ,801 60. .321 1.00 33, .48 F
ATOM 10δ03 CG GLU 566 51.167 92. ,513 60. .570 1.00 33, .48 F
ATOM 10804 CD GLU 566 52.101 93. ,496 59. ,910 1.00 33, .48 F
ATOM 10805 OEl GLU 566 53.275 93. ,546 60. ,304 1.00 33, .48 F
ATOM 10806 OE2 GLU 566 51.6δ2 94. ,211 58. gδδ 1.00 33, .48 F
ATOM 10807 C GLU 566 47.3g7 91. ,846 60. ,815 1.00 33, .48 F
ATOM 1080δ O GLU 566 47.036 91. ,693 61. ,g86 1.00 33, .48 F
ATOM 10δ09 N VAL 567 46.561 92. ,266 59. ,875 1.00 33, .48 F
ATOM 10810 CA VAL 567 45.1δ6 92. ,568 60. ,222 1.00 33, .48 F
ATOM 10811 CB VAL 567 44.372 93. ,008 58. ggs 1.00 33, .48 F
ATOM 10812 CGl VAL 567 42. gog 92. ,919 59. ,2g5 1.00 33, .48 F
ATOM 10813 CG2 VAL 567 44.730 94. ,445 58. ,622 1.00 33, .48 F
ATOM 10814 C VAL 567 44.561 91. ,330 60. ,827 1.00 33, .48 F
ATOM 10815 O VAL 567 43.δδ6 91. ,405 61. ,84g 1.00 33, .48 F
ATOM 10816 N VAL 568 44.δ03 90. ,183 60. ,206 1.00 33, .48 F
ATOM 10817 CA VAL 568 44.246 88. ,936 60. ,711 1.00 33, .48 F
ATOM 10818 CB VAL 568 44.556 87. ,743 59. 792 1.00 33, ,48 F ATOM 10δl9 CGl VAL 568 43,,83δ δ6.530 60..296 1.00 33.48 F
ATOM 10δ20 CG2 VAL 568 44. .132 δ8.033 58. .375 1.00 33, .48 F
ATOM 10821 C VAL 568 44. ,δ42 8δ.649 62. .067 1.00 33, .48 F
ATOM 10822 O VAL 568 44. .174 δ8.122 62. .945 1.00 33, .48 F
ATOM 10823 N GLU 569 46, .112 89.005 62. .229 1.00 33, .48 F
ATOM 10824 CA GLU 569 46. ,811 88.787 63. .488 1.00 33, .48 F
ATOM 10825 CB GLU 56g 48. .305 89.070 63, .324 1.00 33 .48 F
ATOM 10826 CG GLU 56g 49. .155 88.575 64. .492 1.00 33, .48 F
ATOM 10827 CD GLU 56g 48. .601 87.2δ5 65. .112 1.00 33 .48 F
ATOM 10δ2δ OEl GLU 56 48, ,226 δ6.350 64. .347 1.00 33, .48 F
ATOM I0δ2g OE2 GLU 56g 48, ,543 δ7.207 66, .367 1.00 33 .48 F
ATOM 10δ30 C GLU 56g 46, ,217 δ9.67δ 64, .567 1.00 33 .48 F
ATOM 10831 O GLU 569 45, ,9go δg.227 65, .688 1.00 33 .48 F
ATOM 10832 N ASP 570 45, ,g57 go.g37 64, .210 1.00 33 .48 F
ATOM 10δ33 CA ASP 570 45, .362 91.920 65, .116 1.00 33 .48 F
ATOM 10δ34 CB ASP 570 45, .330 93.2δ6 64, .458 1.00 33, .48 F
ATOM 10δ35 CG ASP 570 46, ,6g5 93.7δg 64, .118 1.00 33 .48 F
ATOM 10δ36 ODl ASP 570 46, ,7g5 94.886 63, .513 1.00 33, .48 F
ATOM 10δ37 OD2 ASP 570 47, .668 93.0δ5 64, .462 1.00 33, .48 F
ATOM 10δ3δ C ASP 570 43, ,g33 91.552 65. ,47δ 1.00 33, .48 F
ATOM ιo 3g O ASP 570 43, .615 91.293 66. .639 1.00 33, .48 F
ATOM 10δ40 N ILE 571 43, .074 91.551 64. ,465 1.00 33, .48 F
ATOM 10841 CA ILE 571 41, ,66g 91.232 64. .633 1.00 33 .48 F
ATOM 10δ42 CB ILE 571 40, ,gδδ 91.099 63. .272 1.00 33, .48 F
ATOM 10δ43 CG2 ILE 571 39, .801 90.152 63. .362 1.00 33 .48 F
ATOM 10δ44 CGl ILE 571 40, ,57g 92.4δg 62. ,7δ2 1.00 33, .48 F
ATOM 10δ45 CDl ILE 571 39, .813 g2.47g 61. .492 1.00 33 .48 F
ATOM 10846 C ILE 571 41, .418 δg. 72 65. .433 1.00 33 .48 F
ATOM 10847 O ILE 571 40, .402 δg.δ56 66. .112 1.00 33 .48 F
ATOM 10848 N SER 572 42, ,351 δg.030 65. .363 1.00 33 .48 F
ATOM 1084g CA SER 572 42, .210 87.777 66, ,0δ4 1.00 33 .48 F
ATOM 10850 CB SER 572 43, .138 86. 723 65. .491 1.00 33 .48 F
ATOM 10851 OG SER 572 42, .608 86. 217 64, .272 1.00 33 .48 F
ATOM 10852 C SER 572 42, ,478 δ7.g30 67, .567 1.00 33, .48 F
ATOM 10δ53 O SER 572 42, .027 87.123 68, ,36δ 1.00 33 .48 F
ATOM 10δ54 N THR 573 43. .214 88.g71 67. .931 1.00 33, .48 F
ATOM 10δ55 CA THR 573 43, .518 8g.224 69. ,329 1.00 33 .48 F
ATOM 10856 CB THR 573 44. .914 δg.7δ7 69. ,499 1.00 33, .48 F
ATOM 10857 OGl THR 573 45, ,704 δg.445 68. ,359 1.00 33 .48 F
ATOM 10858 CG2 THR 573 45. ,555 δg.206 70. ,750 1.00 33, .48 F
ATOM 10859 C THR 573 42. ,526 go.230 69. ,903 1.00 33, .48 F
ATOM 10δ60 O THR 573 42. ,774 gθ.δ43 70. ,941 1.00 33, .48 F
ATOM 10861 N GLY 574 41. ,416 o.423 69. ,202 1.00 33, .48 F
ATOM 10862 CA GLY 574 40. ,3δδ 91.322 69. ,688 1.00 33, .48 F ATOM 10863 c GLY 574 40.455 92.794 69..357 1.00 33.48 F
ATOM 10 64 0 GLY 574 39.461 93 .487 69, ,550 1.00 33 .4δ F
ATOM 10δ65 N PHE 575 41.596 93 .277 68, ,δ76 1.00 33 .48 F
ATOM 10δ66 CA PHE 575 41.729 94 .691 68, .546 1.00 33 .48 F
ATOM 10δ67 CB PHE 575 43.2O1 95 .073 68, .413 1.00 33 .48 F
ATOM 1086δ CG PHE 575 44.0O3 94, .841 69, .670 1.00 33 .48 F
ATOM 10869 CDl PHE 575 44.724 93 .673 69, .δ46 1.00 33 .48 F
ATOM 10870 CD2 PHE 575 44.024 95 .789 70, ,6δ2 1.00 33 .48 F
ATOM 10871 CEl PHE 575 45.448 93 .45δ 71, .003 1.00 33 .48 F
ATOM 10δ72 CE2 PHE 575 44.746 95, .576 71, ,δ37 1.00 33, .48 F
ATOM 10δ73 CZ PHE 575 45.458 94, .410 71, ,9g 1.00 33, .48 F
ATOM 10874 C PHE 575 40.962 95, .052 67, .276 1.00 33, .48 F
ATOM 10875 0 PHE 575 40.714 94, .197 66, .426 1.00 33, .48 F
ATOM 10δ76 N ARG 576 40.586 96 .324 67, .160 1.00 33, .48 F
ATOM 10δ77 CA ARG 576 39.801 96, .7g5 66, .031 1.00 33, .48 F
ATOM 10δ7δ CB ARG 576 38.347 96, .g36 66, .464 1.00 33, .48 F
ATOM 10879 CG ARG 576 37.783 95 .720 67, .102 1.00 33, .48 F
ATOM 108δ0 CD ARG 576 37.592 94 .62δ 66, ,0δ9 1.00 33 .48 F
ATOM 10881 NE ARG 576 38.128 93, .373 66, .581 1.00 33, .48 F
ATOM 108δ2 CZ ARG 576 37.474 92, .222 66, .538 1.00 33, .48 F
ATOM 10δδ3 NHl ARG 576 36.257 92, .168 66, .025 1.00 33, .48 F
ATOM 10δδ4 NH2 ARG 576 38.042 91, .123 67, .005 1.00 33, .48 F
ATOM 10δδ5 C ARG 576 40.269 98, .146 65, .539 1.00 33, .48 F
ATOM 10886 0 ARG 576 41.133 98, .768 66, .152 1.00 33, .48 F
ATOM 10887 N LEU 577 39.675 98, .604 64, .437 1.00 33, .48 F
ATOM 1088 δ CA LEU 577 40.000 99, .913 63, .888 1.00 33, .48 F
ATOM 10889 CB LEU 577 39.184 100, .187 62, .627 1.00 33, .48 F
ATOM losgo CG LEU 577 39.539 99. .442 61, .343 1.00 33, .48 F
ATOM 10891 CDl LEU 577 38.382 99. .516 60, .402 1.00 33. .48 F
ATOM 108g2 CD2 LEU 577 40.765 100. .023 60. ,692 1.00 33. ,48 F
ATOM i0 g3 C LEU 577 39.666 100, ,946 64. ,965 1.00 33, ,48 F
ATOM ιo g4 0 LEU 577 38.723 100, .774 65. ,730 1.00 33, .48 F
ATOM 108 g 5 N TYR 57δ 40.452 102, ,013 65. ,035 1.00 33, .48 F
ATOM 108g6 CA TYR 57δ 40.232 103. ,040 66. ,034 1.00 33, .48 F
ATOM 108 7 CB TYR 57δ 41.422 104. ,004 66. ,110 1.00 33, ,48 F
ATOM loδgδ CG TYR 57δ 41.701 104. ,855 64. ,872 1.00 33, .48 F
ATOM loδgg CDl TYR 578 42.813 104. ,622 64. ,0δ6 1.00 33, .48 F
ATOM logoo CEl TYR 578 43.106 105. ,417 63. ,011 1.00 33, .48 F
ATOM 10901 CD2 TYR 578 40.883 105. ,920 64. ,530 1.00 33, .48 F
ATOM ιogo2 CE2 TYR 57δ 41.172 106. ,720 63. ,447 1.00 33, .48 F
ATOM ιogo3 CZ TYR 57δ 42.286 106. ,464 62. ,692 1.00 33, .48 F
ATOM ιogo4 OH TYR 57δ 42.582 107. ,255 61. ,608 1.00 33, ,48 F
ATOM logos C TYR 57δ 38.977 103. ,804 65. 716 1.00 33. ,48 F
ATOM ιogo6 0 TYR 57δ 38.458 103. ,721 64. 612 1.00 33. ,48 F ATOM ιogo7 N LYS 57 38.49g 104.547 66.,703 1.00 33,.48 F
ATOM ιogoδ CA LYS 57 37.303 105.360 66. ,583 1.00 33, .48 F
ATOM logog CB LYS 579 36.68δ 105.550 67. ,964 1.00 33, .48 F
ATOM 10910 CG LYS 579 35 .6g5 106.685 68. ,044 1.00 33, .48 F
ATOM 10911 CD LYS 579 35 .349107.018 69. ,481 1.00 33, .48 F
ATOM 10912 CE LYS 579 34.449108.227 69. ,537 1.00 33, .48 F
ATOM 10913 NZ LYS 579 35 .00610g.305 68. ,682 1.00 33, .48 F
ATOM 10914 C LYS 579 37.62δ 106.728 66. ,002 1.00 33, .48 F
ATOM 10915 0 LYS 579 38 .324 107.518 66. ,637 1.00 33, .48 F
ATOM 10916 N PRO 580 37.143 107.021 64. ,7δ3 1.00 33, .48 F
ATOM 10917 CD PRO 580 36. 549 106.088 63. .818 1.00 33 .48 F
ATOM 10918 CA PRO 580 37.3gg 108.321 64. .155 1.00 33, .48 F
ATOM 10919 CB PRO 580 36.741108.187 62, ,7δ3 1.00 33 .48 F
ATOM 10920 CG PRO 5δ0 35 . δ53 107.012 62, .901 1.00 33, .48 F
ATOM 10921 C PRO 5δ0 36. δ3g 109.475 64, ,gδ3 1.00 33, .48 F
ATOM 10g22 0 PRO 5δ0 35 . δ51109.324 65, ,688 1.00 33 .48 F
ATOM 10g23 N ARG 581 37.483 110.628 64. ,921 1.00 33, .48 F
ATOM ιog24 CA ARG 581 37.017 111.747 65. ,710 1.00 33, .48 F
ATOM ιog25 CB ARG 5δl 37. g42 112.942 65. ,543 1.00 33, .48 F
ATOM 10g26 CG ARG 581 39.342 112.717 66. ,061 1.00 33, .48 F
ATOM 10g27 CD ARG 581 39.356112.113 67, .466 1.00 33, .48 F
ATOM ιog28 NE ARG 581 40.72g 111.962 67. .944 1.00 33, .48 F
ATOM ιog2g CZ ARG 581 41.499112.977 68. .335 1.00 33, .48 F
ATOM ιog3θ NHl ARG 581 41.019 114.221 68. .321 1.00 33, .48 F
ATOM 10931 NH2 ARG 581 42 .763 112.760 68. ,69g 1.00 33, .48 F
ATOM 10932 C ARG 581 35 .625 112.115 65. ,266 1.00 33, .48 F
ATOM 10933 0 ARG 581 34.731112.328 66, ,075 1.00 33, .48 F
ATOM 10934 N LEU 582 35 .438 112.178 63. ,g62 1.00 33, .48 F
ATOM iog35 CA LEU 582 34.147 112.520 63, ,407 1.00 33 .48 F
ATOM ιog36 CB LEU 582 34 .281112.655 61. .sgg 1.00 33, .48 F
ATOM 10g37 CG LEU 582 34.033 114.075 61. ,420 1.00 33, .48 F
ATOM ιog38 CDl LEU 582 34 . 3g3 115.061 62. ,506 1.00 33, .48 F
ATOM ιog3g CD2 LEU 5δ2 34.81δ 114.302 60. ,161 1.00 33, .48 F
ATOM 10940 C LEU 5δ2 33 .074 111.497 63. ,736 1.00 33, .48 F
ATOM 10941 0 LEU 582 31.951111.608 63. ,267 1.00 33, .48 F
ATOM 10942 N ALA 583 33 .416110.504 64. ,544 1.00 33, .48 F
ATOM 10943 CA ALA 583 32 .466109.458 64. ,go3 1.00 33, .48 F
ATOM 10944 CB ALA 583 32 . g 2 108.096 64. ,455 1.00 33, .48 F
ATOM 10945 C ALA 583 32 .167 109.427 66. ,389 1.00 33, .48 F
ATOM 10946 0 ALA 583 33 .066109.250 67. .198 1.00 33, .48 F
ATOM 10947 N SER 584 30 . δg5 109.57g 66. ,733 1.00 33, .48 F
ATOM 10948 CA SER 5δ4 30.456109.574 68. ,116 1.00 33, .48 F
ATOM 1094g CB SER 5δ4 28 . gδδ 109. g83 68. .195 1.00 33, .48 F
ATOM ιog5θ OG SER 584 28 . 1δ0109.22δ 67. ,301 1.00 33, .48 F ATOM 10951 c SER 5δ4 30.636 108.22g 68.7δ6 1.00 33.48 F
ATOM 10952 0 SER 5δ4 30.886 107.232 6δ.l30 1.00 33 .48 F
ATOM 10953 N THR 585 30.488 108.205 70.103 1.00 33 .48 F
ATOM 10954 CA THR 585 30.64g 106. g72 70.δ49 1.00 33 .48 F
ATOM 10955 CB THR 585 30.616 107.214 72.367 1.00 33 .48 F
ATOM 10956 OGl THR 585 29.287 107.533 72.7δ0 1.00 33 .48 F
ATOM 10957 CG2 THR 585 31.519 108.355 72.732 1.00 33 .48 F
ATOM 10958 C THR 585 29.561 105. gδi 70.4g5 1.00 33 .48 F
ATOM 1095g 0 THR 585 29.772 104.780 70.553 1.00 33 .48 F
ATOM ιog6θ N HIS 586 28.395 106.4δg 70.123 1.00 33 .48 F
ATOM 10961 CA HIS 586 27.282 105.625 6g.763 1.00 33 .48 F
ATOM ιog62 CB HIS 586 25.971 106.407 6g.807 1.00 33 .48 F
ATOM ιog63 CG HIS 586 24.768 105.589 6g.45g 1.00 33, .48 F
ATOM 10g64 CD2 HIS 586 23.503 105.954 69.149 1.00 33, .48 F
ATOM ιog65 NDl HIS 586 24.791 104.214 69.414 1.00 33 .48 F
ATOM 10966 CEl HIS 586 23.592 103.766 69.08δ 1.00 33 .48 F
ATOM 10967 NE2 HIS 586 22.794 104.802 6δ.g22 1.00 33 .48 F
ATOM 10968 C HIS 586 27.495 105.047 6δ.3δ0 1.00 33 .48 F
ATOM logεg 0 HIS 586 27.068 103.935 6δ.0g4 1.00 33 .48 F
ATOM iog7o N VAL 587 28.157 105.806 67.516 1.00 33 .48 F
ATOM 10971 CA VAL 587 28.422 105.333 66.164 1.00 33 .48 F
ATOM 10g72 CB VAL 587 2δ.810 106.497 65.215 1.00 33, .48 F
ATOM log73 CGl VAL 587 29.215 105.965 63.865 1.00 33, .48 F
ATOM 10g74 CG2 VAL 587 27.637 107.422 65.041 1.00 33, .48 F
ATOM ιog75 C VAL 587 29.544 104.307 66.215 1.00 33, .48 F
ATOM 10g76 0 VAL 587 29.621103.422 65.377 1.00 33, .48 F
ATOM ιog77 N TYR 588 30.396 104.414 67.22δ 1.00 33, .48 F
ATOM ιog78 CA TYR 588 31.510 103.493 67.380 1.00 33, .48 F
ATOM ιo7g CB TYR 588 32.606 104.144 68.231 1.00 33, .48 F
ATOM logso CG TYR 58δ 33.937 103.433 68.172 1.00 33, .48 F
ATOM 10981 CDl TYR 588 34.520 103.114 66.g57 1.00 33, .48 F
ATOM 10g82 CEl TYR 58δ 35.726 102.456 66.8g8 1.00 33, .48 F
ATOM ιogδ3 CD2 TYR 5δδ 34.610 103.072 6g.332 1.00 33, .48 F
ATOM ιogδ4 CE2 TYR 5δδ 35.811 102.418 εg.27g 1.00 33, .48 F
ATOM ιog 5 CZ TYR 5δδ 36.365 102.112 6δ.060 1.00 33, .48 F
ATOM ιogδ6 OH TYR 5δ8 37.570 101.451 67.g97 1.00 33 .48 F
ATOM ιog87 C TYR 588 31.034 102.171 67.988 1.00 33 .48 F
ATOM lo δ 0 TYR 588 31.555 101.110 67.659 1.00 33, .48 F
ATOM ιogδ9 N GLN 58g 30.040 102.228 68.866 1.00 33, .48 F
ATOM io9go CA GLN 589 29.4g2 101.010 69.464 1.00 33, .48 F
ATOM ιoggι CB GLN 5δ9 28.4g4 101.339 70.566 1.00 33, .48 F
ATOM ιogg2 CG GLN 58g 2g.og2 101.539 71.921 1.00 33, ,48 F
ATOM ιogg3 CD GLN 58g 2δ.g55 100.323 72.762 1.00 33, .48 F
ATOM ιogg4 OEl GLN 58g 2g.280 100.340 73.934 1.00 33, .48 F ATOM 10995 NE2 GLN 589 2δ.469 9g.246 72. ,169 1.00 33..48 F
ATOM 10996 C GLN ssg 2δ.75g 100.207 68. ,401 1.00 33. .48 F
ATOM 10997 O GLN 58g 28.720 98.977 68. ,452 1.00 33. .48 F
ATOM 109gδ N ILE sgo 28.162 100.922 67. ,451 1.00 33, .48 F
ATOM ιoggg CA ILE sgo 27.415 100.310 66. ,367 1.00 33, ,48 F
ATOM 11000 CB ILE sgo 26.640 101.371 65. ,575 1.00 33, .48 F
ATOM 11001 CG2 ILE sgo 26.056 100.755 64, ,324 1.00 33, .48 F
ATOM 11002 CGl ILE sgo 25.554 101.977 66. ,473 1.00 33, ,48 F
ATOM 11003 CDl ILE sgo 24.684 103.052 65. ,δ20 1.00 33, .48 F
ATOM 11004 C ILE sgo 28.352 99.573 65. ,436 1.00 33, .48 F
ATOM 11005 O ILE sgo 28.067 98.453 65. ,016 1.00 33, .48 F
ATOM 11006 N MET 591 2g.473 100.219 65. ,124 1.00 33, .48 F
ATOM 11007 CA MET 591 30.501 99.663 64. ,256 1.00 33, .48 F
ATOM 11008 CB MET 591 31.660 100.645 64. .105 1.00 33, .48 F
ATOM 11009 CG MET 591 31.422 101.826 63. .185 1.00 33 .48 F
ATOM 11010 SD MET 591 32.g03 102.857 63. .127 1.00 33, .48 F
ATOM 11011 CE MET 591 32.233 104.422 62. .895 1.00 33, .48 F
ATOM 11012 C MET 591 31.037 98.409 64. ,892 1.00 33, .48 F
ATOM 11013 O MET 591 31.085 97.352 64. ,286 1.00 33, .48 F
ATOM 11014 N ASN 592 31.445 9δ.548 66, .138 1.00 33, .48 F
ATOM 11015 CA ASN 592 32.008 g7.434 66, ,δ57 1.00 33, .48 F
ATOM 11016 CB ASN 5 2 32.447 g7.881 68, .255 1.00 33, .48 F
ATOM 11017 CG ASN 5g2 33.795 g8.594 68, .239 1.00 33 .48 F
ATOM 11018 ODl ASN 5g2 34.822 97.982 67, .972 1.00 33, .48 F
ATOM 11019 ND2 ASN 5g2 33.790 9g.891 68, .509 1.00 33, .48 F
ATOM 11020 C ASN 5g2 31.046 g6.278 66, ,92δ 1.00 33, .48 F
ATOM 11021 O ASN 5g2 31.450 g5.134 67, .105 1.00 33, .48 F
ATOM 11022 N HIS 5g3 29.765 g6.571 66, ,76δ 1.00 33 .48 F
ATOM 11023 CA HIS 5g3 28.751 g5.534 66, .813 1.00 33 .48 F
ATOM 11024 CB HIS 5g3 27.389 g6.154 67, ,08δ 1.00 33 .48 F
ATOM 11025 CG HIS 593 26.342 95.159 67, .476 1.00 33 .48 F
ATOM 11026 CD2 HIS 593 26.404 93.815 67, ,62δ 1.00 33, .48 F
ATOM 11027 NDl HIS 593 25.030 gs.sio 67, .714 1.00 33, .48 F
ATOM 11028 CEl HIS 593 24.329 g4.425 67, ,991 1.00 33, .48 F
ATOM 11029 NE2 HIS 593 25.139 g3.383 67, .944 1.00 33, .48 F
ATOM 11030 C HIS 593 28.751 g4.793 65, ,4δ3 1.00 33 .48 F
ATOM 11031 O HIS 593 28.339 g3.645 65, .404 1.00 33 .48 F
ATOM 11032 N CYS 594 29.225 g5.457 64, .436 1.00 33 .48 F
ATOM 11033 CA CYS 5g4 29.2g6 94.839 63, .120 1.00 33 .48 F
ATOM 11034 CB CYS 5g4 29.428 95.898 62, .027 1.00 33, .48 F
ATOM 11035 SG CYS 5g4 2δ.063 97.046 61. ,δ22 1.00 33, .48 F
ATOM 11036 C CYS 5g4 30.536 g3.959 63. .089 1.00 33 .48 F
ATOM 11037 0 CYS 5g4 30.651 93.039 62. .289 1.00 33 .48 F
ATOM 11038 N TRP 595 31.476 94.248 63, .972 1.00 33 .48 F ATOM ιi03g CA TRP 595 32.,702 93,,4δ6 63..998 1.00 33,.48 F
ATOM 11040 CB TRP 595 33. ,88 94, ,418 64. ,195 1.00 33, .48 F
ATOM 11041 CG TRP 595 34. .011 95. ,418 63. .116 1.00 33 .48 F
ATOM 11042 CD2 TRP 595 34. .461 96. ,760 63. .248 1.00 33, .48 F
ATOM 11043 CE2 TRP 595 34. .463 97, .327 61. .963 1.00 33 .48 F
ATOM 11044 CE3 TRP 595 34. ,864 97, .543 64. .330 1.00 33, .48 F
ATOM 11045 CDl TRP 595 33. ,763 95, .227 61. .792 1.00 33, .48 F
ATOM 11046 NEl TRP 595 34. ,032 96, .367 61, ,089 1.00 33, .48 F
ATOM 11047 CZ2 TRP 595 34. .851 98, .637 61, .732 1.00 33, .48 F
ATOM 1104δ CZ3 TRP 595 35. ,245 98, .836 64, ,09g 1.00 33, .48 F
ATOM 11049 CH2 TRP 595 35. ,237 99, .375 62, ,811 1.00 33, .48 F
ATOM 11050 C TRP 595 32. ,735 92, ,3δ3 65, .032 1.00 33, .48 F
ATOM 11051 0 TRP 595 33. ,781 91, .806 65, .274 1.00 33, .48 F
ATOM 11052 N LYS 596 31. ,601 92, .087 65, .651 1.00 33, .48 F
ATOM 11053 CA LYS 596 31. ,565 91. .012 66, .627 1.00 33, .48 F
ATOM 11054 CB LYS 5g6 30. ,137 90, .745 67, ,090 1.00 33, .48 F
ATOM 11055 CG LYS 5g6 29. ,651 91, .712 68, ,148 1.00 33, .48 F
ATOM 11056 CD LYS 5gε 30. ,454 91, .560 69, .414 1.00 33, .48 F
ATOM 11057 CE LYS 5g6 30. .072 92, .597 70, .444 1.00 33, .48 F
ATOM 11058 NZ LYS 5g6 30. .508 93, .976 70, .056 1.00 33, .48 F
ATOM 11059 C LYS 5g6 32. .130 89, .796 65, .921 1.00 33, .48 F
ATOM 11060 0 LYS 5g6 31. .915 89, .615 64, .732 1.00 33, .48 F
ATOM 11061 N GLU 5 7 32, .860 88, .967 66, .654 1.00 33, .48 F
ATOM 11062 CA GLU 597 33. ,487 87. .800 66, .061 1.00 33, .48 F
ATOM 11063 CB GLU 597 34. .405 87. .150 67, .064 1.00 33, .48 F
ATOM 11064 CG GLU 597 35. .357 86, .192 66, .441 1.00 33, .48 F
ATOM 11065 CD GLU 597 35. .953 85, .294 67, .482 1.00 33, .48 F
ATOM 11066 OEl GLU 597 36. .331 85, ,837 68, .557 1.00 33, .48 F
ATOM 11067 OE2 GLU 597 36. ,032 84, .060 67. ,230 1.00 33, .48 F
ATOM 11068 C GLU 597 32. ,502 86, .778 65, .543 1.00 33, .48 F
ATOM 11069 0 GLU 597 32. ,554 86, .389 64, .385 1.00 33, .48 F
ATOM 11070 N ARG 598 31. ,608 86, .318 66, .402 1.00 33, .48 F
ATOM 11071 CA ARG 598 30. ,605 85, .355 65, ,95g 1.00 33, .48 F
ATOM 11072 CB ARG 59δ 29. ,852 84, ,727 67, ,155 1.00 33, .48 F
ATOM 11073 CG ARG 59δ 30. .718 83, ,9g7 68. .184 1.00 33, .48 F
ATOM 11074 CD ARG sgs 29. ,925 82, .gog 68, .sgg 1.00 33, .48 F
ATOM 11075 NE ARG 598 30, ,634 82, .331 70, .045 1.00 33 .48 F
ATOM 11076 CZ ARG 59δ 30. ,274 81. .195 70. .651 1.00 33, .48 F
ATOM 11077 NHl ARG sgδ 29. ,220 80. ,506 70. .213 1.00 33, .48 F
ATOM 11078 NH2 ARG sgδ 30. ,941 80. ,753 71. ,714 1.00 33, .48 F
ATOM 11079 C ARG sgδ 29. ,602 86. .ogs 65, .060 1.00 33, .48 F
ATOM 11080 0 ARG sgδ 29, ,006 87. ,og5 65, .462 1.00 33, .48 F
ATOM 11081 N PRO sgg 29. ,423 85. ,621 63. .824 1.00 33, .48 F
ATOM 11082 CD PRO 599 30. ,154 84. ,531 63. ,158 1.00 33, .48 F ATOM 11083 CA PRO 599 2δ.4δ7 86.253 62.901 1.00 33, .48 F
ATOM 11084 CB PRO 599 2δ.491 85.293 61.723 1.00 33, .48 F
ATOM 11085 CG PRO 599 29.894 84.808 61.713 1.00 33, .48 F
ATOM 11086 C PRO 599 27.100 86.405 63.526 1.00 33, .48 F
ATOM 11087 0 PRO 599 26.373 87.344 63.218 1.00 33, .48 F
ATOM 11088 N GLU 600 26.749 85.479 64.415 1.00 33, .48 F
ATOM 11089 CA GLU 600 25.450 85.485 65.089 1.00 33, .48 F
ATOM 11090 CB GLU 600 25.271 84.19g 65.δ96 1.00 33, .48 F
ATOM 11091 CG GLU 600 25.694 82.960 65.144 1.00 33, .48 F
ATOM 11092 CD GLU 600 27.200 82.796 65.093 1.00 33 .48 F
ATOM 11093 OEl GLU 600 27.71δ 82.346 64.048 1.00 33 .48 F
ATOM 11094 OE2 GLU 600 27.860 83.105 66.1O4 1.00 33, .48 F
ATOM 11095 C GLU 600 25.266 86.671 66.029 1.00 33, .48 F
ATOM 11096 0 GLU 600 24.145 86.994 66.420 1.00 33, .48 F
ATOM 11097 N ASP 601 26.363 87.311 66.403 1.00 33, .48 F
ATOM 11098 CA ASP 601 26.274 8δ.429 67.307 1.00 33, .48 F
ATOM 11099 CB ASP 601 27.442 δδ.415 68.267 1.00 33, .48 F
ATOM 11100 CG ASP 601 27.404 87.238 69.184 1.00 33, ,48 F
ATOM 11101 ODl ASP 601 26.2δ9 86.g34 69.677 1.00 33, .48 F
ATOM 11102 OD2 ASP 601 2δ.4δl 86.631 69.417 1.00 33, .48 F
ATOM 11103 C ASP 601 26.244 8g.747 66.588 1.00 33, .48 F
ATOM 11104 0 ASP 601 26.140 go.δθ3 67.213 1.00 33, .48 F
ATOM 11105 N ARG 602 26.344 δg.70δ 65.272 1.00 33, .48 F
ATOM 11106 CA ARG 602 26.325 90.955 64.539 1.00 33, .48 F
ATOM 11107 CB ARG 602 27.165 90.856 63.268 1.00 33, .48 F
ATOM 11108 CG ARG 602 2δ.627 90.559 63.533 1.00 33, .48 F
ATOM 11109 CD ARG 602 29.244 89.886 62.332 1.00 33, .48 F
ATOM 11110 NE ARG 602 30.532 89.294 62.656 1.00 33, .48 F
ATOM lllll CZ ARG 602 31.212 88.512 61.834 1.00 33, .48 F
ATOM 11112 NHl ARG 602 30.725 88.229 60.641 1.00 33, .48 F
ATOM 11113 NH2 ARG 602 32.376 88.011 62.204 1.00 33, .48 F
ATOM 11114 C ARG 602 24.δ91 91.215 64.201 1.00 33, .48 F
ATOM 11115 0 ARG 602 24.099 90.285 64.093 1.00 33, .48 F
ATOM 11116 N PRO 603 24.523 92.4δ9 64.076 1.00 33, .48 F
ATOM 11117 CD PRO 603 25.265 g3.676 64.533 1.00 33, .48 F
ATOM 11118 CA PRO 603 23.141 g2.δl9 63.743 1.00 33, ,48 F
ATOM 11119 CB PRO 603 23.041 94.2δδ 64.141 1.00 33, .48 F
ATOM 11120 CG PRO 603 24.457 4.7 5 63.960 1.00 33, .48 F
ATOM 11121 C PRO 603 22.δ27 g2.572 62.272 1.00 33, .48 F
ATOM 11122 0 PRO 603 23.695 92.211 61.489 1.00 33, .48 F
ATOM 11123 N ALA 604 21.567 92.750 61.913 1.00 33, .48 F
ATOM 11124 CA ALA 604 21.115 92.572 60.541 1.00 33, .48 F
ATOM 11125 CB ALA 604 19.δ26 91.794 60.510 1.00 33, .48 F
ATOM 11126 C ALA 604 20.882 g3.g48 59.969 1.00 33, ,48 F ATOM 11127 0 ALA 604 20.551 94, .877 60,.696 1.0033.48 F
ATOM 11128 N PHE 605 21.049 94, .094 58, .665 1.00 33 .48 F
ATOM 11129 CA PHE 605 20.827 95, .395 58, .061 1.00 33 .48 F
ATOM 11130 CB PHE 605 21.036 95, .312 56, .549 1.00 33 .48 F
ATOM 11131 CG PHE 605 22.467 95, .132 56, .160 1.00 33 .48 F
ATOM 11132 CDl PHE 605 23.400 96, .094 56, .475 1.00 33 .48 F
ATOM 11133 CD2 PHE 605 22.886 93, .992 55, .501 1.00 33 .48 F
ATOM 11134 CEl PHE 605 24.715 gs, .931 56, ,145 1.00 33 .48 F
ATOM 11135 CE2 PHE 605 24.203 g3, .δ22 55. ,168 1.00 33, .48 F
ATOM 11136 CZ PHE 605 25.119 94, .δ02 55. ,494 1.00 33, .48 F
ATOM 11137 C PHE 605 19.424 95, .δ96 58. ,414 1.00 33, .48 F
ATOM 11138 O PHE 605 19.145 97, .088 58. ,344 1.00 33, .48 F
ATOM 11139 N SER 606 18.552 94, .97g 58. ,810 1.00 33, .48 F
ATOM 11140 CA SER 606 17.202 95, .337 59. .196 1.00 33, .48 F
ATOM 11141 CB SER 606 16.418 94, .083 59. ,522 1.00 33 .48 F
ATOM 11142 OG SER 606 16.943 92, .992 58. ,788 1.00 33, .48 F
ATOM 11143 C SER 606 17.331 96, .178 60. ,448 1.00 33, .48 F
ATOM 11144 O SER 606 16.809 97, .285 60. ,531 1.00 33, .48 F
ATOM 11145 N ARG 607 18.041 95, ,641 61. ,432 1.00 33, .48 F
ATOM 11146 CA ARG 607 18.242 96, ,352 62. ,679 1.00 33, .48 F
ATOM 11147 CB ARG 607 18.854 95, .432 63. ,730 1.00 33, .48 F
ATOM 11148 CG ARG 607 19.410 96, .194 64, ,915 1.00 33, .48 F
ATOM 11149 CD ARG 607 19.853 95, .273 66, ,046 1.00 33, .48 F
ATOM 11150 NE ARG 607 18.780 95, .043 67. ,011 1.00 33, .48 F
ATOM 11151 CZ ARG 607 18.622 95, .748 68. ,127 1.00 33, .48 F
ATOM 11152 NHl ARG 607 19.470 96, .726 68. ,421 1.00 33, .48 F
ATOM 11153 NH2 ARG 607 17.621 95, .478 68. ,954 1.00 33, .48 F
ATOM 11154 C ARG 607 19.123 97, .573 62, ,478 1.00 33, .48 F
ATOM 11155 O ARG 607 18.δ05 98, .639 62. ,973 1.00 33, .48 F
ATOM 11156 N LEU 608 20.221 97, .423 61. ,745 1.00 33, .48 F
ATOM 11157 CA LEU 608 21.12δ 98, .537 61. ,501 1.00 33, .48 F
ATOM 11158 CB LEU 608 22.276 98, .100 60. ,580 1.00 33, .48 F
ATOM 11159 CG LEU 608 23.502 97, .526 61. ,299 1.00 33, .48 F
ATOM 11160 CDl LEU 608 24.46δ 96, .880 60. ,320 1.00 33, .48 F
ATOM 11161 CD2 LEU 608 24.165 98. .638 62. ,075 1.00 33, .48 F
ATOM 11162 C LEU 608 20.412 99. .737 60. ,892 1.00 33, .48 F
ATOM 11163 0 LEU 608 20.602 100. ,8δ9 61. ,313 1.00 33, .48 F
ATOM 11164 N LEU 6og 19.590 99. ,461 59. 890 1.00 33, .48 F
ATOM 11165 CA LEU 6og lδ.δ47 100. ,509 59. 211 1.00 33. .48 F
ATOM 11166 CB LEU 6og 17.985 99. ,879 58. 118 1.00 33. .48 F
ATOM 11167 CG LEU 6og 17.458 100. ,802 57. 032 1.00 33. ,48 F
ATOM 11168 CDl LEU 6og 18.518 101. ,791 56. 609 1.00 33. ,48 F
ATOM 1116g CD2 LEU 6og 17.015 99. ,968 55. 870 1.00 33. ,48 F
ATOM 11170 C LEU 6og i7.gg3 101. 235 60. 251 1.00 33. ,48 F ATOM 11171 0 LEU 609 17.961102.463 60,.307 1.00 33.48 F
ATOM 11172 N ARG 610 17.322 100.44 61, .086 1.00 33, .4δ F
ATOM 11173 CA ARG 610 16.469 loo. g4g 62, .155 1.00 33, .4δ F
ATOM 11174 CB ARG 610 15.970 gg.75δ 62, ,g7i 1.00 33, .4δ F
ATOM 11175 CG ARG 610 14.474 gg.56i 63, .038 1.00 33, .4δ F
ATOM 11176 CD ARG 610 13.920 100.210 64, ,2g5 1.00 33, .48 F
ATOM 11177 NE ARG 610 13.940 101.670 64, .220 1.00 33, .48 F
ATOM 1117δ CZ ARG 610 13.65δ 102.47δ 65, .23g 1.00 33, .48 F
ATOM 11179 NHl ARG 610 13.340 loi. 7i 66, .428 1.00 33, .48 F
ATOM lllδO NH2 ARG 610 13.676 103.7 4 65, .060 1.00 33, .4δ F
ATOM lllδl C ARG 610 17.26δ loi. gi 63, .053 1.00 33, .48 F
ATOM ιιiδ2 0 ARG 610 16.868 103.016 63, .315 1.00 33 .48 F
ATOM lllδ3 N GLN 611 18.409 101.413 63, .517 1.00 33 .48 F
ATOM lllδ4 CA GLN 611 19.278 102.185 64, .387 1.00 33 .48 F
ATOM ui 5 CB GLN 611 20.431 101.32g 64, .δ62 1.00 33, .48 F
ATOM 11186 CG GLN 611 20.047 100.363 65, . 887 1.00 33, .4δ F
ATOM 11187 CD GLN 611 21.230 gg.go4 66, .631 1.00 33, .4δ F
ATOM niδδ OEl GLN 611 21.932 gδ.gg2 66, ,ιg4 1.00 33, .48 F
ATOM lllδ9 NE2 GLN 611 21.495 100.545 67, .765 1.00 33, .48 F
ATOM 11190 C GLN 611 19.δ70 103.43g 63, ,7g7 1.00 33, .48 F
ATOM 11191 0 GLN 611 ιg.g26 104.463 64, ,45g 1.00 33, .48 F
ATOM 11192 N LEU 612 20.35g 103.349 62, ,56δ 1.00 33, .48 F
ATOM 11193 CA LEU 612 20.g65 104.509 61, ,g42 1.00 33, .48 F
ATOM 11194 CB LEU 612 21.54g 104.133 60. ,57δ 1.00 33, .48 F
ATOM 11195 CG LEU 612 22.73δ 103.15δ 60. .582 1.00 33, .48 F
ATOM 11196 CDl LEU 612 23.251 102.993 59. .164 1.00 33, .48 F
ATOM 11197 CD2 LEU 612 23.848 103.664 61. .481 1.00 33, .48 F
ATOM 11198 C LEU 612 ιg.g73 105.659 61. .812 1.00 33, .48 F
ATOM 11199 0 LEU 612 20.30δ 106.79δ 62. ,115 1.00 33, ,4δ F
ATOM 11200 N ALA 613 lδ.747 105.365 61. ,3gι 1.00 33, ,4δ F
ATOM 11201 CA ALA 613 17.730 106.401 61. ,23g 1.00 33, .48 F
ATOM 11202 CB ALA 613 16.523 105. δ46 60. ,530 1.00 33, .48 F
ATOM 11203 C ALA 613 17.315 107.011 62. ,570 1.00 33, .48 F
ATOM 11204 0 ALA 613 16.741 10δ.0g4 62. ,605 1.00 33, .48 F
ATOM 11205 N GLU 614 17.5gθ 106.316 63. ,664 1.00 33. ,48 F
ATOM 11206 CA GLU 614 17.25g 106.841 64. ,g85 1.00 33. ,48 F
ATOM 11207 CB GLU 614 17.2gθ 105.724 66. ,038 1.00 33. ,4δ F
ATOM 11208 CG GLU 614 16.254 104.633 65. ,778 1.00 33. ,4δ F
ATOM 11209 CD GLU 614 16.551 103.2gδ 66. ,470 1.00 33. ,4δ F
ATOM 11210 OEl GLU 614 16.585 103.255 67. ,725 1.00 33. ,4δ F
ATOM 11211 OE2 GLU 614 16.741 102.286 65. 743 1.00 33. ,4δ F
ATOM 11212 C GLU 614 lδ.2δ6 107. gii 65. 318 1.00 33. .48 F
ATOM 11213 0 GLU 614 17. g40 108. g77 65. 826 1.00 33. .48 F
ATOM 11214 N ILE 615 ig.554 107.62g 65. ,031 1.00 33, .48 F ATOM 11215 CA ILE 615 20.596108.602 65. 298 1.00 33..48 F
ATOM 11216 CB ILE 615 21. 994 108. 098 64. 900 1.00 33, .48 F
ATOM 11217 CG2 ILE 615 23. 009 iog. 189 65. 110 1.00 33, .48 F
ATOM 11218 CGl ILE 615 22. 396 106. 907 65.753 1.00 33, .48 F
ATOM 11219 CDl ILE 615 23. 735 106. 299 65. 349 1.00 33, .48 F
ATOM 11220 C ILE 615 20. ,258 iog. ,797 64.425 1.00 33, .48 F
ATOM 11221 O ILE 615 20. ,370 110. ,943 64.848 1.00 33, .48 F
ATOM 11222 N ALA 616 19. ,835 iog. ,521 63 . 19g 1.00 33, .48 F
ATOM 11223 CA ALA 616 19. ,483 no. ,592 62. 283 1.00 33, .48 F
ATOM 11224 CB ALA 616 19. ,149 110. ,022 60.905 1.00 33, .48 F
ATOM 11225 C ALA 616 18. ,285 111. ,330 62 .856 1.00 33, .48 F
ATOM 11226 O ALA 616 18. ,349 112. ,539 63 . 106 1.00 33, .48 F
ATOM 11227 N GLU 617 17. ,201 110. ,577 63 .059 1.00 33, .48 F
ATOM 11228 CA GLU 617 15. ,947 111. ,089 63. 611 1.00 33, .48 F
ATOM 11229 CB GLU 617 15. ,215 iog. ,974 64. 372 1.00 33, .48 F
ATOM 11230 CG GLU 617 13. ,751 iog. ,733 63 .996 1.00 33, .48 F
ATOM 11231 CD GLU 617 13. ,586 108. .943 62. 696 1.00 33, .48 F
ATOM 11232 OEl GLU 617 13. ,745 iog. .552 61.612 1.00 33, .48 F
ATOM 11233 OE2 GLU 617 13. ,310 107. .712 62.753 1.00 33, .48 F
ATOM 11234 C GLU 617 16. ,251 112. .245 64. 570 1.00 33, .48 F
ATOM 11235 O GLU 617 16, .188 113. .412 64.179 1.00 33, .48 F
ATOM 11236 N SER 618 16. .597 Ill, ,907 65.813 1.00 33, .48 F
ATOM 11237 CA SER 618 16. .902 112. ,902 66.837 1.00 33, .48 F
ATOM 11238 CB SER 618 18. ,080 112. ,436 67. 69g 1.00 33. .48 F
ATOM 11239 OG SER 618 17. .692 111. ,379 68. 563 1.00 33, .48 F
ATOM 11240 C SER 618 17. .205 114. ,285 66. 26g 1.00 33, .48 F
ATOM 11241 O SER 618 16. .394 115. ,211 66. 531 1.00 33, .48 F
ATOM 11242 OXT SER 618 lδ. ,239 114. ,424 65. 566 1.00 33, .48 F
TER 11243 SER 618 F
ATOM 11244 Cl BIR 1 16. ,444 187, ,209 8.477 1.00 33, .48 C
ATOM 11245 C2 BIR 1 16, ,300 187, ,773 9. 797 1.00 33, .48 C
ATOM 11246 C3 BIR 1 15, .117 187, ,639 10. 501 1.00 33 .48 C
ATOM 11247 C4 BIR 1 14. .010 186. ,935 9. 936 1.00 33, .48 C
ATOM 11248 C5 BIR 1 14. ,137 186. ,389 8.657 1.00 33, .48 C
ATOM 11249 C6 BIR 1 15, ,335 186. ,518 7.922 1.00 33, .48 C
ATOM 11250 Nl BIR 1 14, ,73g 188. ,075 11. 744 1.00 33 .48 C
ATOM 11251 C7 BIR 1 13, ,482 187. .661 11.940 1.00 33 .48 C
ATOM 11252 N2 BIR 1 13, .002 186. .971 10.887 1.00 33 .48 C
ATOM 11253 Cδ BIR 1 13, .141 188, .651 14. 343 1.00 33 .48 C
ATOM 11254 N3 BIR 1 12, .803 187, .975 13 .213 1.00 33 .48 C
ATOM 11255 Ol BIR 1 14. .182 189. .242 14. 565 1.00 33 .48 C
ATOM 11256 C9 BIR 1 11, .169 lδδ, .δδ2 17.421 1.00 33 .48 C
ATOM 11257 CIO BIR 1 10, .267 188. .048 16. 768 1.00 33 .48 C
ATOM 1125δ Si BIR 1 10, ,8og 187. .664 15 .218 1.00 33, .48 C ATOM 11259 Cll BIR 1 12.223 188.572 15.355 1.00 33.48 C
ATOM 11260 C12 BIR 1 12.284 189.182 16.622 1.00 33.48 C
ATOM 11261 C13 BIR 1 11.652 186.377 10.783 1.00 33.48 C
ATOM 11262 C14 BIR 1 ιo.go7 185.783 11.992 1.00 33.48 C
ATOM 11263 C15 BIR 1 10.743 184.249 11.908 1.00 33.48 C
ATOM 11264 N4 BIR 1 11.346 183.547 12.881 1.00 33.48 C
ATOM 11265 02 BIR 1 10.084 183.723 11.004 1.00 33.48 C
ATOM 11266 C16 BIR 1 18.251 188.577 7.535 1.00 33.48 C
ATOM 11267 N5 BIR 1 17.643 187.340 7.771 1.00 33.48 C
ATOM 11268 03 BIR 1 ig.462 188.666 7.506 1.00 33.48 C
ATOM 11269 C17 BIR 1 17.474 189.931 7.294 1.00 33.48 C
ATOM 11270 C18 BIR 1 18.481 191.066 6.902 1.00 33.48 C
ATOM 11271 C19 BIR 1 17.736 192.402 6.713 1.00 33.48 C
ATOM 11272 C20 BIR 1 16.665 192.258 5.608 1.00 33.48 C
ATOM 11273 C21 BIR 1 15.650 191.145 5.990 1.00 33.48 C
ATOM 11274 C22 BIR 1 16.389 189.804 6.165 1.00 33.48 C
ATOM 11275 C23 BIR 1 lδ.2δ0 186.071 7.407 1.00 33.48 C
TER 11276 BIR 1 C
ATOM 11277 Cl BIR 1 35.761 144.216 73.495 1.00 33.48 D
ATOM 11278 C2 BIR 1 36.116 143.816 72.185 1.00 33.48 D
ATOM 11279 C3 BIR 1 35.262 143.043 71.434 1.00 33.48 D
ATOM 11280 C4 BIR 1 34.000 142.629 71.953 1.00 33.48 D
ATOM 11281 C5 BIR 1 33.647 143.004 73.234 1.00 33.48 D
ATOM 11282 C6 BIR 1 34.512 143.794 74.013 1.00 33.48 D
ATOM 11283 Nl BIR 1 35.366 142.543 70.168 1.00 33.48 D
ATOM 11284 C7 BIR 1 34.245 141.877 69.919 1.00 33.48 D
ATOM 11285 N2 BIR 1 33.397 141.900 70.954 1.00 33.48 D
ATOM 11286 C8 BIR 1 34.δ73 141.157 67.524 1.00 33.48 D
ATOM 11287 N3 BIR 1 34.0δ3 141.244 68.613 1.00 33.48 D
ATOM 1128δ 01 BIR 1 36.001 141.595 67.425 1.00 33.48 D
ATOM 11289 eg BIR 1 33.932 139.820 64.211 1.00 33.48 D
ATOM 11290 cio BIR 1 32.692 139.577 64.788 1.00 33.48 D
ATOM 11291 si BIR 1 32.671 140.064 66.403 1.00 33.48 D
ATOM 11292 cii BIR 1 34.271 140.601 66.400 1.00 33.4δ D
ATOM 11293 C12 BIR 1 34.δ33 140.404 65.126 1.00 33.48 D
ATOM 11294 C13 BIR 1 32. Oδl 141.267 70.994 1.00 33.48 D
ATOM 11295 C14 BIR 1 31.185 141.203 69.770 1.00 33.4δ D
ATOM 11296 C15 BIR 1 30.066 142.238 69.823 1.00 33.4δ D
ATOM 11297 N4 BIR 1 29.δl4 142.874 68.680 1.00 33.4δ D
ATOM 11298 02 BIR 1 2g.448 142.440 70.856 1.00 33.4δ D
ATOM 11299 C16 BIR 1 37.70δ 144.576 74.915 1.00 33.48 D
ATOM 11300 N5 BIR 1 36.60g 145.023 74.217 1.00 33.48 D
ATOM 11301 03 BIR 1 38.3g6 145.359 75.553 1.00 33.48 D
ATOM 11302 C17 BIR 1 38.166 143.103 74.979 1.00 33.48 D ATOM 11303 C18 BIR 1 39.70δ 143.,032 75..197 1.00 33.48 D
ATOM 11304 C19 BIR 1 40.165 141. ,568 75. .234 1.00 33 .48 D
ATOM 11305 C20 BIR 1 3g.440 140. ,829 76. ,377 1.00 33, .48 D
ATOM 11306 C21 BIR 1 37.912 140. .883 76. .150 1.00 33 .48 D
ATOM 11307 C22 BIR 1 37.446 142. .350 76, ,117 1.00 33, .48 D
ATOM 11308 C23 BIR 1 36.1δ4 146. .436 74, .237 1.00 33, .48 D
TER 11309 BIR 1 D
ATOM 11310 C01 007 1 131.059 53. .265 45, .626 1.00 33 .48 E
ATOM 11311 C02 007 1 12g.δδ2 54. .278 45, .857 1.00 33, .48 E
ATOM 11312 C03 007 1 130.310 55. .374 46, .883 1.00 33, .48 E
ATOM 11313 C04 007 1 130.6δ6 54. ,709 48, .230 1.00 33, .48 E
ATOM 11314 CO5 007 1 131.853 53. ,701 48, .oog 1.00 33, .48 E
ATOM 11315 C06 007 1 131.426 52. .601 46, ,g87 1.00 33 .48 E
ATOM 11316 C07 007 1 130.617 52. .179 44, .sgo 1.00 33 .48 E
ATOM 11317 N08 007 1 131.457 51. .797 43, .567 1.00 33 .48 E
ATOM 11318 O09 007 1 129.510 51. .668 44, .712 1.00 33 .48 E
ATOM 11319 CIO 007 1 131.179 52, .383 42. .256 1.00 33 .48 E
ATOM 11320 Cll 007 1 132.471 50, .880 43, .681 1.00 33 .48 E
ATOM 11321 C12 007 1 133.813 51. ,271 43, .gδo 1.00 33, .48 E
ATOM 11322 C13 007 1 134.821 50. .304 44, .076 1.00 33 .48 E
ATOM 11323 C14 007 1 134.514 48. ,922 43, ,δ73 1.00 33, .48 E
ATOM 11324 C15 007 1 133.197 48. .563 43, ,5δδ 1.00 33 .48 E
ATOM 11325 C16 007 1 132.179 49. .523 43, .491 1.00 33, .48 E
ATOM 11326 N17 007 1 136.160 50. .400 44, .335 1.00 33 .48 E
ATOM 11327 C18 007 1 136.659 49. .168 44, .294 1.00 33, .48 E
ATOM 11328 N19 007 1 135.741 48. .228 44. .021 1.00 33, .48 E
ATOM 11329 C20 007 1 135.164 44. .354 43. .337 1.00 33, .48 E
ATOM 11330 C21 007 1 134.896 45. .849 43. .527 1.00 33, .48 E
ATOM 11331 C22 007 1 136.060 46. .758 43. .895 1.00 33 .48 E
ATOM 11332 C23 007 1 132.299 43. .289 41. .045 1.00 33, .48 E
ATOM 11333 N24 007 1 132.118 41. .891 41, .513 1.00 33 .48 E
ATOM 11334 C25 007 1 132.308 41. .770 42, ,9go 1.00 33 .48 E
ATOM 11335 C26 007 1 133.701 42. ,321 43, .417 1.00 33 .48 E
ATOM 11336 N27 007 1 133. δ70 43. .740 42, ,g67 1.00 33 .48 E
ATOM 11337 C2δ 007 1 133.669 43. ,δ69 41. .484 1.00 33, .48 E
ATOM 1133δ C29 007 1 130.796 41. .385 41, .090 1.00 33 .48 E
ATOM 11339 C30 007 1 139.152 49. ,564 44. ,657 1.00 33, .48 E
ATOM 11340 N31 007 1 13δ.056 48. ,794 44, ,4δ5 1.00 33 .48 E
ATOM 11341 032 007 1 139.149 50. ,770 44, ,δ48 1.00 33, .48 E
ATOM 11342 C33 007 1 142.791 47. ,368 44, .297 1.00 33 .48 E
ATOM 11343 C34 007 1 142. 36 48. ,751 44. .487 1.00 33, .48 E
ATOM 11344 C35 007 1 141.635 49. ,477 44. ,608 1.00 33, .48 E
ATOM 11345 C36 007 1 140.392 48. ,795 44. ,539 1.00 33, .48 E
ATOM 11346 C37 007 1 140.375 47. ,38O 44. ,346 1.00 33, .48 E ATOM 11347 C38 007 1 141.581 46.680 44.226 1.00 33.48 E
ATOM 11348 139 007 1 144.519 46.325 44.108 1.00 33.48 E
TER 11349 007 1 E
ATOM 11350 C01 007 1 33.492 113.814 35.444 1.00 33.48 F
ATOM 11351 C02 007 1 33.292 115.357 35.387 1.00 33.48 F
ATOM 11352 C03 007 1 32.334 115.709 34.222 1.00 33.48 F
ATOM 11353 C04 007 1 32.934 115.206 32.883 1.00 33.48 F
ATOM 11354 C05 007 1 33.143 113.664 32.943 1.00 33.48 F
ATOM 11355 C06 007 1 34.100 113.312 34.103 1.00 33.48 F
ATOM 11356 C07 007 1 34.430 113.463 36.625 1.00 33.48 F
ATOM 11357 N08 007 1 33.931 112.768 37.696 1.00 33.48 F
ATOM 11358 009007 1 35.625 113.788 36.561 1.00 33.48 F
ATOM 11359 CIO 007 1 33.455 113.571 38.δ30 1.00 33.48 F
ATOM 11360 Cll 007 1 33.869 111.400 37.738 1.00 33.48 F
ATOM 11361 C12 007 1 32.650 110.747 37.488 1.00 33.48 F
ATOM 11362 C13 007 1 32.579 109.371 37.527 1.00 33.48 F
ATOM 11363 C14 007 1 33.758 lθδ.574 37.818 1.00 33.48 F
ATOM 11364 C15 007 1 34.966 109.214 38.064 1.00 33.48 F
ATOM 11365 C16 007 1 35.030 110.638 38.021 1.00 33.48 F
ATOM 11366 N17 007 1 31.529 108.525 37.326 1.00 33.48 F
ATOM 11367 C18 007 1 31.993 107.308 37.486 1.00 33.48 F
ATOM 11368 N19 007 1 33.295 107.253 37.787 1.00 33.48 F
ATOM 11369 C20 007 1 34.997 103.995 38.473 1.00 33.48 F
ATOM 11370 C21007 1 35.287 105.506 38.3δ6 1.00 33.48 F
ATOM 11371 C22 007 1 33.895 105.934 3δ.008 1.00 33.4δ F
ATOM 11372 C23 007 1 36.177 100.490 39.338 1.00 33.4δ F
ATOM 11373 N24007 1 37.384 100.435 38.456 1.00 33.4δ F
ATOM 11374 C25 007 1 38.121 101.749 38.432 1.00 33.48 F
ATOM 11375 C26 007 1 37.169 102.888 37.969 1.00 33.48 F
ATOM 11376 N27 007 1 35.978 102.976 38.857 1.00 33.48 F
ATOM 11377 C28 007 1 35.247 101.655 38.934 1.00 33.48 F
ATOM 11378 C29007 1 38.271 99.323 38.879 1.00 33.48 F
ATOM 11379 C30007 1 29.970105.773 37.116 1.00 33.48 F
ATOM 11380 N31007 1 31.248 106.052 37.391 1.00 33.48 F
ATOM 11381 032 007 1 29.131 106.581 36.761 1.00 33.48 F
ATOM 11382 C33 007 1 29.078 101.638 37.778 1.00 33.48 F
ATOM 11383 C34007 1 28.046 102.572 37.740 1.00 33.48 F
ATOM 11384 C35 007 1 28.331 103.927 37.519 1.00 33.4δ F
ATOM 11385 C36 007 1 29.675 104.342 37.332 1.00 33.48 F
ATOM 11386 C37 007 1 30.713 103.370 37.371 1.00 33.48 F
ATOM 113δ7 C38 007 1 30.402 102.024 37.595 1.00 33.48 F
ATOM 1138δ 139 007 1 28.654 99.660 38.108 1.00 33.48 F END Table 10 Partial Sequence Alignments of Kinase Domain Motifs to Define Compound Binding-Site Regions Residue numbering is according to that for full-length human ITK kinase
Human Kinases 367 369 379 387 370 371 406 410 499 500 501 377 389 391 419 433 435 436 437 438 439 440 441 442 486 48<
Figure imgf000295_0001
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BF510751Jjm: K I E M G H E M s D F V A K I I L E L A Q G G D E L BIKE: E L L C A E E D F V L R V I M E Y C R A G Q E L BLK: R L M K G S E M A D F V A K V I T E Y M A R G C A L BMPR1A: R V M K G K E D L V A K L L T D Y H E N G S K L BMPR1B: K I M K G K E D L V A K L L T D Y H E N G S K L BMPR2: E I K P G R N D F V A K A L M E Y Y P N G S R L
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BMX: K L L D G S E M s D F V A K V I T E Y I S N G C R L BRAF: Q I K A G S E L G D F V K L L I T Q w C E G s S N F BTK: K L Y D G T E M S D F V A K V I T E Y M A N G C R L BUB1 : H L E K G E G M I D L V V K M L G E L Y S Y G T D I BUB1B: K E V Y L N K V D F F E T H I W H Q Y I N T R I C20orf64: E V R A K Q E L S T H V V K P L M E E I E G S T S L C20orf97: V L Q E P L A L E N A T K A Y F F T R T H G D C V C8FW: . , . I L E S R K T Y F F E K S F G D R V CAD38729: E P K S G S A S L S P I P V T R E V P H Q T E L CAMK1: D L L L G T L S D F V A K V L M Q L V S G G E E L CAMK1G: E L L L G s L T D F V A K V L M Q L V s G G E E L CAMK2A: E L R E G K C A D F V A K V L F D L V T G G E E L CAMK2B: E I R E G K C A D F V A K V L F D L V T G G E E L CAMK2D: E L R G G K C A D F V A K V L F D L V T G G E E L CAMK2G: E L R E G K C A D F V A K V L F D L V T G G E E L CAMK4: S L R P G R L A D F V A K I L L E L V T G G E E L CAMKK1: S L G K E L D F V A K V L F D L L R K G P s L CAMKK2: D L G K E L . D F V A K V M F E L V N Q G P s L CASK: E R Q G K C G G F V A K V M F E F M D G A D H L CCRK: G K I G E E L A D F V A K V L F E F M L s D E A L CDC2: E K V G E E L A D F V A K V Y I F E F L s M D Q L CDC2L1: N R I E E E I G D F V A K V Y V M N Y V E H D s L CDC2L2: N R I E E E I G D F V A K V Y V M N Y V E H D S L CDC2L5: G K M G E E L A D F V A K I Y V F E Y M D H D S L CDC42BPB: K V I G R V A D F V A K T L M D Y Y V G G D D L CDC7L1: D L K G E L T V D F V A K M I M P Y L E H E S S L CDC7L1 X: D L K G E L T V D F V A K M I M P Y L E H E S S L CDK10: N R I G E E L A D F V A K V F V M G Y C E Q D S L CDK2: E K V G E E L A D F V A K V Y V F E F L H Q D Q L CDK3: E K L G E E A D F V A K V Y V F E F L S Q D Q L CDK4: A K F G V E L A D F V A K V T V F E H V D Q D E L
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KIAA1297 1 Q I R E G R L C D F L A K L I T E L C T E E E L
KIAA1297 2 E K A T A R E L V D F V V K M L A E S C G N R E D L KIAA1361 R I F V G H L A D F V A K I L M E Y C L G , δ G L KIAA1639 T I Q A Q R E L V D L V A K A L L E L C S G P E E I
KIAA1765 R I E A G D I A D F V A K V L L E Y V Q G G D E L KIAA1804: E I R E G A E F T D F V A K I L L E F A R G G A S L KIAA1811: K L L G K E L D F V A K L L L E H V s G G E E L KIAA1855 E K L D F V L C V M Q L Q G R S A KIAA1883 Q I L Q G S E Y G D Y V V K L L M E F C Q L G D R L KIS S L R P G S E L I D F V A K V L L E L L D V S E R L KIT K L E T G A E L C D F V A K V V T E Y C C Y G D R L KPI2 Q I L R G N N Y G D Y V I K L L F E F C D L G D R F KSR E I R A G Q E Y G L F V R L V I T S F C K G R T K F LATS1 K L L L G I I T D F V A K V F M D Y I P G G D D L LATS2 K L L L G I I T D F V A K V F M D Y I P G G D D L LCK E L M K G A E M A D F V A K V I T E Y M E N G S A L LIMK1 E L K E G K E M A D F A M M L F T E Y I K G G T H L LIMK2 E L K K G K E M A D F A M M L L T E Y I E G G T H L LOC119794 V G H . I I L L T F N T G E S L L0C120392 R V Q E A S E M S D F V A K V I M E F M A N G S G L LOC120892 A D Y H L LOC121064 K I L Q S Q V A N LOC122134 K I L Q G R E M L G H V V K I L M E Y A L E G V Q L LOC125806 E I H A G K E Y G L F V R I V I T S L C K G R T K F
LOC126030 1 R L L A G S E G G D L V A K L F Q E Y A P C G D D L
LOC126030 2 R L L P G Q E G T D F V A K V F T E P V L H G D E L LOC130736 A T K V G E E L C D F V A K V L F E Y C D H T L E L LOC132187 C D F I V V E Y C K Y G N R L LOC137298 E N E P A E D A C D I S A S D F E D I Q M S Q S K L LOC 37839 . E I K I G E E L A D F V A K V T V F K F C H Q H Q L LOC139728 E L L L G S . L S D F V A K V L M E L V T G G E E L LOC149420 R V E R G R V E A D F V A K V Q V E T s L K G E D L LOC152110 LOC154813 E I K V G V E H G D L V A K V I N E Y C N G G S S F LOC166614 K I E E G D L G D F V A K I L M E L V K G G D E L LOC167359 G I L G S E M D F V A K I L M E Y A G G G E E F LOC168921 R L E V G K H . C A K V V L E P C R R R S G F LOC169727 R P A I E S S H R S F L M L S T T W G R s G G R R L LOC197259 L K R E E M A G F L A K L I M E Y C E L G T S L LOC219756 LOC220231 . H L K Y D R K R T E L V A K I T L E Y C E G N D G L
LOC220435 K I L H G Q G D F A V K I M E Y C D G G D Q F LOC253939 K E K P I N I H V C M V L G Q L LOC254078 R L L K G K E T A D F V A K I F Q E Y A P A G D E L LOC256669 E L D F K L L L E H V S G G E E L LOC51086 E I K I G S E L A D F V A K I I τ Q Y I S G G s H L LOC91461XP038576: V R K L V R A M A Q L A A K G F L V D G E L K D L L LOC91807 E L R P G G M I D F V A K I L M E Y V D G G E E L LOC92335 T I L Y G K S S G L V T R V V T S F M A Y G S S L LTK R L E Q G H E I • G D F V A K V I L E L M S G G D R L LYN K L M K G A E M A D F V A K V I T E Y M A K G S A L MAK R L M L G D E L A D F V A K I F F E Y M K E N L E L MAP2K1 S L K V G A L C D F V A K V I M E H M D G S S L MAP2K2 S L K G A L C D F V A K V I M E H M D G » S S L MAP2K3 S L K G R N C D F V A K V I M E L M D T S K s L MAP2K4 G I K G R V C D F V A K V I M E L M S T S K s L MAP2K5 D L K G H L C D F V A K I I T E F M D G s s L MAP2K6 M L K G R S C D F V A K V I M E L M D T s K s L o MAP2K7 G M K V G S V C D F V A K V I M E L M G T C K s L o MAP3K1 Q I Q L G L E M A D F C A K I L I E W M A G G s A L MAP3K10 E I R E G V E F T D F V A K I L M E Y A R G G A I L MAP3K11 E I R L G I E F T D F V A K I L M E Y A A G G P N L MAP3K12 Q V L E G s D L s D F V A K I I M E F C A Q G Q P L MAP3K13 Q L L E G s D L s D F V A K I I M E Y C A H G Q P L MAP3K14 L L R Q G R A L C D F V A K V I M E L L E G G s D L MAP3K2 K L L E G Q L G D F V A K V I M E Y M P G G s A L MAP3K3 K L L E G Q L G D F V A K V I M E Y M P G G S A L MAP3K4 N I T L G E E F G D F V A K V I M E Y C D E G E A F MAP3K5 V L A R G K H S D F V A K V I M E Q V P G G S D L MAP3K6 L L A R G K H S D F V A K V I M E E V P G G S D L MAP3K7 E V K G R E L C D F V A K V L M E Y A E G G S P L MAP3K8 D I L R P R F V D F V A K A L M E A G E G G s s V MAP3K9 E I R E G I E F T D F V A K I L M E F A R G G P S L MAP4K1 Q L K L G G L A D F V A K V I M E F C G A G s A L MAP4K2 Q V K L G A L A D F V A K V I M E F C G G G s A L MAP4K3 Q I K L G S M A D F V A K V I M E F C G G G s A L MAP4K4 E V K L G N L V D F V A K A L M E F C G A G s Q L MAP4K5 Q V K L G S V A D F V A K V I M E Y C G G G s A L
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NJ NTRK1 W L L L G E E L G D F V A K V M F E Y M R H G D R L NTRK2 R L L L G E E L G D F V A K V M F E Y M K H G D R L NTRK3 R L L L G E E L G D F V A K V M F E Y M K H G D R L OSR1 E 1 A K G S M A D F V A K V L M K L L S G G S G L PACE1 Y A V N V L S C C R P V A K V K S Q A T P E F S D S PAK1 E T E G Q M T D F V A K V V M E Y L A G G S D L PAK2 E T E G Q M T D F V A K V V M E Y L A G G S D L PAK3 E T E G Q M T D F V A K V V M E Y L A G G S D L PAK4 1 1 L G E M s D F V A K V V M E F L E G G A D L PAK6 V L Q G E M s D F V A K V V M E F L Q G G A D L PAK7 1 1 Q G E M s D F V A K V V M E F L E G G A D L PASK S L T E G S E L 1 D F V V K 1 L M E K H G S G D E V PCTK1 D L K L G E E L A D F V A K V T V F E Y L D K D Q L PCTK2 E L K L G E E L A D F V A K V T V F E Y L D K D Q L PCTK3 D L K L G E E L A D F V A K V T V F E Y L D S D Q L PDGFRA R L E K G S E M C D F V A K V 1 T E Y C F Y G D R L PDGFRB R L E K G S E M C D F V A K V 1 T E Y C R Y G D R L PDPK1 K L L E G E E M T D F V A K V F L s Y A K N G E E L
PFTK1 E L K L G E E L A D F V A K V T V F E Y V H T D Q L PHKG1 E L R G R E L D F V A K I L F D L M K R G E E L PHKG2 D I R G R E L D F V A K I L F D L M R K G E E L PIK3R4 K L R L G S E R T D F V V K Q L R Q Y V R D N E M PIM1 P L S G S E L I D F V A K I I E R P E P V Q D E L PIM2 P L A G K E L I D F V A K I V E R P L P A Q D E L PIM3 A L A . G S E L I D F V A K I V E R P E P A Q D E L PINK1 Q I E P G K E A A D F V A K I T F L V M K N Y T D L PK428 K I V V G R V A D F V A K T L M D Y Y V G G D D L PKD2 E L G D G S L C D F V A K V V M E K L H G . D E L PKMYT1 S L K L G H E H G D F V A K V L T E L C G P S A F PKNBETA A L L Y G R L A D F V A K L F T E F V P G G D D L PLK R L E V G K . H . D F C A K V V L E L C R R R S G F PRKAA1 D L V . G V E L , D F V A K I M M E Y V s G G E E L PRKAA2 D L I G V E L D F V A K I M M E Y V s G G E E L PRKACA K L L H G T I T D F V A K V M M E Y V P G G E E L
LO PRKACB K L L Y G T I T D F V A K V M M E Y V P G G E E L O LO PRKACG R L L H G M I T D F V A K V L M E Y V P G G E E L PRKCA M L L L G K L A D F V A K T F M E Y V N G G D D M PRKCB1 M L L L G K L A D F V A K T F M E Y V N G G D D M PRKCD K L L Y G K L A D F V A K T F M E F L N G G D D L PRKCE K L L V G K L A D F V A K T F M E Y V N G G D D L PRKCG M L L L G K L T D F V A K T F M E Y V T G G D D M PRKCH R L L L G K L A D F V A K T F M E F V N G G D D L PRKCI R I L I G R F T D Y V A K V F I E Y V N G G D D L PRKCL1 : A L L L G R L A D F V A K V F M E Y s A G G D D L PRKCL2 A L L M G R F A D F V A K V F M E Y A A G G D D L PRKCM : E L G D G S L C D F V A K V V M E K L H G D E L PRKCN E L G D G S L C D F V A K V V M E K L H G D E L PRKCQ K L L F G K L A D F V A K T F M E Y L N G G D D L PRKCZ R I L I G R F T D Y V A K V L I E Y V N G G D D L PRKG1 D L L T G V I V D F V A K V M M E A C L G G E E I PRKG2 A L L A G V I V D F V A K V M L E A C L G G E E I PRKR ■ E I K T G S K V G D F V V K D I M E F C D K G T S F PRKWNK1 I I K E G R E D L V A C V L T E L M T S G T D F PRKWNK2 : I L K E G R E D L V A C V L T E L M T S G T D F PRKWNK3 I L K E G R E D L V A C V L T E L M T S G T D F
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VRK3 T K T D Q W A G Y K R WEE1 E I K I G S H G D L V A K V I N E Y C N G G S S F XP_016922_jjm S L K I D A L C D F V A K V I M E H M D G S s L XP_065057 V Q L L P K L D R W V L M L L C G D M P T T D Y L XP_167231 P F K K G R M D F V A K I L M E Y V D G G E E L YES1 V L M K G Q E M A D F V A K V I T E F M S K G S A L ZAK: E C R G G E L C D F V I T E Y A S L G S R V ZAP70 Q D M D V A K V M M A G G G R L ITK identical residues: 33 183 129 50 445 75 240 119 72 469 413 432 420 455 245 177 38 338 83 111 75 33 365 10 96 399 % Identity 6.3 35 25 9.6 86 14 46 23 14 90 79 83 81 88 47 34 7.3 65 16 21 14 6.3 70 1.9 18 77
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-4

Claims

What is Claimed is:
1. A crystalline composition comprising an ITK kinase domain-ligand complex.
2. The crystalline composition according to claim 1 wherein the ITK kinase domain is human.
3. The crystalline composition according to claim 2, wherein said composition effectively diffracts X-rays such that the atomic coordinates of the ITK kinase domain-ligand complex can be determined to a resolution of better than 5.0 Angstroms.
4. The crystalline composition according to claim 2, wherein said composition effectively diffracts X-rays such that the atomic coordinates of the ITK kinase domain-ligand complex can be determined to a resolution of 3.0 Angstroms or better.
5. The crystalline composition according to claims 2, 3 or 4 wherein the ITK kinase domain is chosen from ITK/KD/Q343 (SEQ ID NO. 9), ITK/KD/G354 (SEQ ID NO. 1) and ITK/KD/S361 (SEQ ID NO. 12).
6. The crystalline composition according to claims 2, 3 or 4 wherein the ITK kinase domain is ITK/KD/G354 (SEQ ID NO. 1).
7. The crystalline composition according to claim 1 wherein the crystals have a hexagonal unit cell whereby unit cell parameters are limited to a=b≠c and alpha=beta=90° and gamma=120°, and the crystal space group symmetry is P64 and has unit cell dimensions α=b=239.68A, c=97.12A wherein the unit cell parameters can vary by 1 to 2%.
8. The crystalline composition according to any of claims 1-7, wherein said ITK kinase domain- ligand complex has a three-dimensional structure comprising the atomic coordinates as defined in Table 9.
9. The crystalline composition according to any of claims 1-7, wherein the ligand is one chosen from Table 2.
10. An isolated polypeptide binding pocket comprising the homologous amino acid residues, based on the kinase-domain residue alignments presented in Table 10, to Q367, 1369, L379, K387, and F437 of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 0.42 Angstroms from the coordinates given in Table 9.
11. An isolated polypeptide binding pocket wherein the isolated polypeptide binding pocket comprises amino acid residues Q367, 1369, L379, K387, and F437 of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9.
12. An isolated polypeptide binding pocket comprising the homologous amino acid residues, based on the kinase-domain residue alignments presented in Table 10, to N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501, Q367, 1369, L379, K387 (RES-SETl) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 0.79 Angstroms from the coordinates given in Table 9.
13. An isolated polypeptide binding pocket wherein the isolated polypeptide binding pocket comprises amino acid residues N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501, Q367, 1369, L379, K387 (RES-SETl) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9.
14. An isolated polypeptide binding pocket comprising the homologous amino acid residues, based on the kinase-domain residue alignments presented in Table 10, to N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501 (RES-SET2) of SEQ ID NO. 1, numbered based on the position in the full-length, wild- type human ITK kinase wherein the backbone-atom R.m.s.d is less than 0.74 Angstroms from the coordinates given in Table 9.
15. An isolated polypeptide binding pocket wherein the isolated polypeptide binding pocket comprises amino acid residues N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489, G370, S371, E406, M410, S499, D500, F501 (RES-SET2) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9,
16. An isolated polypeptide binding pocket comprising the homologous amino acid residues, based on the kinase-domain residue alignments presented in Table 10, to N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489 (RES-SET3) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 0.60 Angstroms from the coordinates given in Table 9.
17. An isolated polypeptide binding pocket wherein the isolated polypeptide binding pocket comprises amino acid residues N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489 (RES-SET3) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9.
18. An isolated polypeptide binding pocket comprising the homologous amino acid residues, based on the kinase-domain residue alignments presented in Table 10, to N377, A389, K391, N419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489,Q367, 1369, L379, K387 (RES- SET4) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 0.47 Angstroms from the coordinates given in Table 9.
19. An isolated polypeptide binding pocket wherein the isolated polypeptide binding pocket comprises amino acid residues V377, A389, K391, V419, L433, F435, E436, F437, M438, E439, H440, G441, C442, R486, L489,Q367, 1369, L379, K387 (RES-SET4) of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9.
20. The isolated polypeptide binding pocket according to any one of claims 10-19 wherein the ligand is one chosen from Table 2.
21. The binding pocket according to claim 10, wherein F437 of said binding pocket interacts with a ligand, said interaction resulting in a distance of about 3.8 Angstroms between F437 and the ligand.
22. A method of obtaining crystals of the ITK kinase domain protein of SEQ ID NO. 1 in a complex with a ligand, said process comprising:
(a) obtaining a crystallizable composition, with said crystallizable composition comprising an ITK kinase domain protein, cations and a ligand; and
(b) subjecting the composition of step (a) to conditions which promote crystallization.
23. The process according to claim 22, wherein the ligand is one chosen from Table 2.
24. A method of identifying an ITK inhibitor, said method comprising : identifying a compound as a potential inhibitor by performing rational drug design with a three- dimensional structure determined for the crystalline composition according to claim 1 ; synthesizing the compound; determining whether the compound inhibits the activity of ITK.
25. The method according to claim 24, wherein the rational drug design is performed in conjunction with computer modeling.
26. A method of identifying an ITK inhibitor, said method comprising: contacting a compound with a binding pocket according to claim 10; determining whether the compound inhibits the activity of ITK.
27. A computer assisted method for identifying an inhibitor of ITK activity comprising: supplying a computer modeling application with a set of coordinates of the binding pocket according to any one of claims 10-19; supplying a computer modeling application with a set of coordinates of one or more chemical entities; scoring the binding modes for said one or more chemical entities; and selecting an inhibitor based on the assigned binding mode scores.
28. The method according to claim 27 wherein the computer modeling application is further supplied with a set of coordinates in Table 9.
29. A method of growing crystals comprising providing a solution of SEQ ID NO. 1 polypeptide complexed with a ligand; providing a precipitant solution; and combining the precipitant and solution of SEQ ID NO. 1 polypeptide complexed with a ligand; and allowing crystals of SEQ ID NO. 1 polypeptide complexed with a ligand to form.
30. The method according to claim 29 wherein the precipitant is 5 to 15% polyethylene glycol 1500 (PEG 1500) and is provided by vapor diffusion.
31. The method according to claim 29 wherein the precipitant is 8 to 12% polyethylene glycol 1500 (PEG 1500).
32. An isolated polypeptide chosen from SEQ ID NO. 1, SEQ ID NO. 9, SEQ ID NO. 10 and SEQ ID NO. 12.
33. A method of determining the three-dimensional structure of a complex comprising one or more ligands and an ITK kinase domain, comprising:
a) crystallizing the ITK kinase domain-ligand complex;
b) obtaining X-ray diffraction data for the crystals of said ITK kinase domain-ligand complex;
c) using the atomic coordinates of Table 9 to determine the three dimensional structure of the ITK kinase domain-ligand complex.
34. An isolated polypeptide chosen from SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15 and SEQ ID NO. 16. . .,
35. An isolated polypeptide binding pocket comprising amino acid residues F435, M438, and C442 of SEQ ID NO. 1, numbered based on the position in the full-length, wild-type human ITK kinase wherein the backbone-atom R.m.s.d is less than 3 Angstroms from the coordinates given in Table 9.
36. The binding pocket according to claim 35, wherein F435, M438, and C442 of said binding pocket interacts with a ligand, said interaction resulting in a distance of about 4 Angstroms between the ligand and the aromatic side chain of F435, of about 2.7 Angstroms between the ligand and the backbone nitrogen atom of M438, of about 3.1 Angstroms between the ligand and the backbone carbonyl oxygen of M438, and of about 2.7 Angstroms between the ligand and the side chain sulfur atom ofC442.
37. An isolated polypeptide binding pocket comprising amino acid residues F435 and M438 of SEQ ED NO. 1, numbered based on the position in the full length, wild type human ITK kinase, wherein F435 and M438 of said binding pocket interacts with a ligand, said interaction resulting in a distance of about 4 Angstroms between the ligand and the aromatic side chain of F435, of about 2.7 Angstroms between the ligand and the backbone nitrogen atom of M438, and of about 3.1 Angstroms between the ligand and the backbone carbonyl oxygen of M438.
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US11180496B2 (en) 2017-07-12 2021-11-23 Daewoong Pharmaceutical Co., Ltd. 1H-pyrazolopyridine derivative and pharmaceutical composition comprising the same
WO2019074275A1 (en) 2017-10-11 2019-04-18 주식회사 대웅제약 Novel phenylpyridine derivative and pharmaceutical composition containing same
US11149019B2 (en) 2017-10-11 2021-10-19 Daewoong Pharmaceutical Co., Ltd. Phenylpyridine derivative and pharmaceutical composition comprising the same
WO2020045941A1 (en) 2018-08-27 2020-03-05 주식회사 대웅제약 Novel heterocyclic amine derivative and pharmaceutical composition comprising same
WO2021172922A1 (en) 2020-02-26 2021-09-02 주식회사 대웅제약 Method for preparation of heterocyclicamine derivatives

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