WO2005065647A3 - Drug granule coatings that impart smear resistance during mechanical compression - Google Patents

Drug granule coatings that impart smear resistance during mechanical compression Download PDF

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Publication number
WO2005065647A3
WO2005065647A3 PCT/US2004/043931 US2004043931W WO2005065647A3 WO 2005065647 A3 WO2005065647 A3 WO 2005065647A3 US 2004043931 W US2004043931 W US 2004043931W WO 2005065647 A3 WO2005065647 A3 WO 2005065647A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
disclosed
substrate
coating
granule
mechanical compression
Prior art date
Application number
PCT/US2004/043931
Other languages
French (fr)
Other versions
WO2005065647A2 (en )
Inventor
David Edgren
Alya Khan
Abdul Majid Qureshi
James Ergun
Satishkumar Ramachandran
Noymi Yam
Original Assignee
Alza Corp Inc
David Edgren
Alya Khan
Abdul Majid Qureshi
James Ergun
Satishkumar Ramachandran
Noymi Yam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

A drug formulation is disclosed comprising granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a drug formulation consisting of a tablet core made by mechanical compression, wherein said tablet core comprises granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a dosage form for oral administration of topiramate, comprising a tablet core and an osmotic delivery system. Methods for controlling topiramate release patterns by altering the composition of the topiramate dosage form are also disclosed.
PCT/US2004/043931 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression WO2005065647A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US53311203 true 2003-12-29 2003-12-29
US53347003 true 2003-12-29 2003-12-29
US60/533,470 2003-12-29
US60/533,112 2003-12-29

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2004312083A AU2004312083A1 (en) 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression
JP2006547568A JP2007517062A (en) 2003-12-29 2004-12-28 Coated drug granules impart adhesion resistance during mechanical compression
CA 2551825 CA2551825A1 (en) 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression
EP20040815921 EP1701707A2 (en) 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression
MXPA06007511A MXPA06007511A (en) 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression.

Publications (2)

Publication Number Publication Date
WO2005065647A2 true WO2005065647A2 (en) 2005-07-21
WO2005065647A3 true true WO2005065647A3 (en) 2005-12-08

Family

ID=34752987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043931 WO2005065647A3 (en) 2003-12-29 2004-12-28 Drug granule coatings that impart smear resistance during mechanical compression

Country Status (4)

Country Link
EP (1) EP1701707A2 (en)
JP (1) JP2007517062A (en)
CA (1) CA2551825A1 (en)
WO (1) WO2005065647A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007169273A (en) * 2005-11-28 2007-07-05 Takeda Chem Ind Ltd Medicinal preparation of which attachment to pestle is improved
JP5527921B2 (en) * 2006-12-22 2014-06-25 エスエス製薬株式会社 Oral solid composition concealed bitterness
DE102012014848A1 (en) * 2012-07-27 2012-10-31 Heilerde-Gesellschaft Luvos Just GmbH & Co. KG Healing clay-composition present as non-coated or as coated granules, comprises healing clay and binding agent containing at least one water soluble polymer e.g. starch, tragacanth or cellulose acetate, cellulose ether
CA2906172A1 (en) * 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of topiramate

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044581A2 (en) * 1998-03-04 1999-09-10 Ortho-Mcneil Pharmaceutical, Inc. Pharmaceutical composition of topiramate
WO2003090723A1 (en) * 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Modified-release vasopeptidase inhibitor formulation, combinations and method
WO2004002447A2 (en) * 2002-06-26 2004-01-08 Alza Corporation Dosage forms for increasing the solubility and extending the release of drugs such as e.g. topiramate and phenyton
WO2004010970A1 (en) * 2002-07-29 2004-02-05 Alza Corporation Formulations and dosage forms for controlled delivery of topiramate
WO2005016306A2 (en) * 2003-08-06 2005-02-24 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
WO2005020959A2 (en) * 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
WO2005063206A1 (en) * 2003-12-23 2005-07-14 Alza Corporation Methods and dosage forms for increasing solubility of drug compositions for controlled delivery

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044581A2 (en) * 1998-03-04 1999-09-10 Ortho-Mcneil Pharmaceutical, Inc. Pharmaceutical composition of topiramate
WO2003090723A1 (en) * 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Modified-release vasopeptidase inhibitor formulation, combinations and method
WO2004002447A2 (en) * 2002-06-26 2004-01-08 Alza Corporation Dosage forms for increasing the solubility and extending the release of drugs such as e.g. topiramate and phenyton
WO2004010970A1 (en) * 2002-07-29 2004-02-05 Alza Corporation Formulations and dosage forms for controlled delivery of topiramate
WO2005016306A2 (en) * 2003-08-06 2005-02-24 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
WO2005020959A2 (en) * 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
WO2005063206A1 (en) * 2003-12-23 2005-07-14 Alza Corporation Methods and dosage forms for increasing solubility of drug compositions for controlled delivery

Also Published As

Publication number Publication date Type
WO2005065647A2 (en) 2005-07-21 application
JP2007517062A (en) 2007-06-28 application
CA2551825A1 (en) 2005-07-21 application
EP1701707A2 (en) 2006-09-20 application

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