WO2005063211A3 - Method of producing lipid complexed camptothecin-carboxylate - Google Patents

Method of producing lipid complexed camptothecin-carboxylate Download PDF

Info

Publication number
WO2005063211A3
WO2005063211A3 PCT/EP2004/014686 EP2004014686W WO2005063211A3 WO 2005063211 A3 WO2005063211 A3 WO 2005063211A3 EP 2004014686 W EP2004014686 W EP 2004014686W WO 2005063211 A3 WO2005063211 A3 WO 2005063211A3
Authority
WO
WIPO (PCT)
Prior art keywords
camptothecin
carboxylate
producing lipid
lipid complexed
producing
Prior art date
Application number
PCT/EP2004/014686
Other languages
French (fr)
Other versions
WO2005063211A2 (en
Inventor
Heinrich Haas
Christian Welz
Thomas Fichert
Ralf Mehrwald
Toralf Peymann
Original Assignee
Medigene Ag
Heinrich Haas
Christian Welz
Thomas Fichert
Ralf Mehrwald
Toralf Peymann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ag, Heinrich Haas, Christian Welz, Thomas Fichert, Ralf Mehrwald, Toralf Peymann filed Critical Medigene Ag
Priority to EP04804277A priority Critical patent/EP1696885A2/en
Priority to US10/584,349 priority patent/US20070148221A1/en
Publication of WO2005063211A2 publication Critical patent/WO2005063211A2/en
Publication of WO2005063211A3 publication Critical patent/WO2005063211A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A method for producing a cationic liposomal preparation comprising a camptothecin drug with enhanced physical and chemical stability, a cationic liposomal preparation obtainable by this method and a pharmaceutical compositions thereof are disclosed.
PCT/EP2004/014686 2003-12-23 2004-12-23 Method of producing lipid complexed camptothecin-carboxylate WO2005063211A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04804277A EP1696885A2 (en) 2003-12-23 2004-12-23 Method of producing lipid complexed camptothecin-carboxylate
US10/584,349 US20070148221A1 (en) 2003-12-23 2004-12-23 Method of producing lipid complexed camptothecin-carboxylate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03029813.7 2003-12-23
EP03029813A EP1547582A1 (en) 2003-12-23 2003-12-23 Method of producing lipid complexed camptothecin-carboxylate

Publications (2)

Publication Number Publication Date
WO2005063211A2 WO2005063211A2 (en) 2005-07-14
WO2005063211A3 true WO2005063211A3 (en) 2006-06-15

Family

ID=34530730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/014686 WO2005063211A2 (en) 2003-12-23 2004-12-23 Method of producing lipid complexed camptothecin-carboxylate

Country Status (3)

Country Link
US (1) US20070148221A1 (en)
EP (2) EP1547582A1 (en)
WO (1) WO2005063211A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111088A2 (en) * 2008-01-02 2009-09-11 The Johns Hopkins University Antitumor immunization by liposomal delivery of vaccine to the spleen
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CA2781529C (en) * 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
CN109414408B (en) * 2016-05-16 2022-03-29 得克萨斯州大学系统董事会 Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010166A1 (en) * 1990-12-11 1992-06-25 Sintetica S.A. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
EP0538534A1 (en) * 1987-04-14 1993-04-28 Research Triangle Institute Improved process for chemical reactions on camptothecin or analogs thereof
US5834012A (en) * 1995-05-03 1998-11-10 Roman Perez-Soler Lipid complexed topoisomerase I inhibitors
WO2001005372A2 (en) * 1999-07-16 2001-01-25 Alza Corporation A liposome composition having resistance to freeze/thaw damage
US20030133973A1 (en) * 1998-09-16 2003-07-17 Slater James L. Liposome-entrapped topoisomerase inhibitors
WO2004002454A1 (en) * 2002-06-26 2004-01-08 Medigene Oncology Gmbh Camptothecin-carboxylate formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
WO1997030696A1 (en) * 1996-02-26 1997-08-28 Daiichi Pharmaceutical Co., Ltd. Liposome and liposome dispersion
WO2004092378A2 (en) * 2003-04-18 2004-10-28 The University Of British Columbia Method for treatment of cancerous angiogenic disorders

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538534A1 (en) * 1987-04-14 1993-04-28 Research Triangle Institute Improved process for chemical reactions on camptothecin or analogs thereof
WO1992010166A1 (en) * 1990-12-11 1992-06-25 Sintetica S.A. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
US5834012A (en) * 1995-05-03 1998-11-10 Roman Perez-Soler Lipid complexed topoisomerase I inhibitors
US20030133973A1 (en) * 1998-09-16 2003-07-17 Slater James L. Liposome-entrapped topoisomerase inhibitors
WO2001005372A2 (en) * 1999-07-16 2001-01-25 Alza Corporation A liposome composition having resistance to freeze/thaw damage
WO2004002454A1 (en) * 2002-06-26 2004-01-08 Medigene Oncology Gmbh Camptothecin-carboxylate formulations
EP1393719A1 (en) * 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations

Also Published As

Publication number Publication date
EP1547582A1 (en) 2005-06-29
EP1696885A2 (en) 2006-09-06
WO2005063211A2 (en) 2005-07-14
US20070148221A1 (en) 2007-06-28

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