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WO2005059929A3 - Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes - Google Patents

Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes

Info

Publication number
WO2005059929A3
WO2005059929A3 PCT/US2004/042022 US2004042022W WO2005059929A3 WO 2005059929 A3 WO2005059929 A3 WO 2005059929A3 US 2004042022 W US2004042022 W US 2004042022W WO 2005059929 A3 WO2005059929 A3 WO 2005059929A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
magnetic
particles
electromagnetic
rod
tip
Prior art date
Application number
PCT/US2004/042022
Other languages
French (fr)
Other versions
WO2005059929A2 (en )
Inventor
Xing-Xiang Li
Tianxin Wang
Original Assignee
Xing-Xiang Li
Tianxin Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00Magnets
    • H01F7/06Electromagnets; Actuators including electromagnets
    • H01F7/20Electromagnets; Actuators including electromagnets without armatures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use

Abstract

Disclosed herein are electromagnetic rod devices, systems and methods using the same, for manipulating magnetic particles within a fluid sample well to facilitate processing the magnetic particles for detection of analytes bound thereto. The electromagnetic rods are used to transfer magnetic particles between different sample wells in a multi-step analyte detection procedure and /or to facilitate washing of the magnetic particles within a sample well. The electromagnetic rod devices include an upper portion, and a lower portion configured as a tip or configured to engage a disposable tip sheath. Magnetic particles are alternatively engaged and disengaged with the surface of the tip or the tip sheath by turning the electromagnet on and off at selected times. The electromagnetic rod devices may optionally be configured with an actuator assembly to move the electromagnetic rod devices vertically and/or horizontally in an instrument system configured for performing biological assays.
PCT/US2004/042022 2003-12-12 2004-12-13 Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes WO2005059929A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US52926103 true 2003-12-12 2003-12-12
US60/529,261 2003-12-12

Publications (2)

Publication Number Publication Date
WO2005059929A2 true WO2005059929A2 (en) 2005-06-30
WO2005059929A3 true true WO2005059929A3 (en) 2005-08-04

Family

ID=34699957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/042022 WO2005059929A3 (en) 2003-12-12 2004-12-13 Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes

Country Status (1)

Country Link
WO (1) WO2005059929A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9329194B2 (en) 2007-11-05 2016-05-03 Abbott Laboratories Automated analyzer for clinical laboratory

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
US8691149B2 (en) * 2007-11-06 2014-04-08 Abbott Laboratories System for automatically loading immunoassay analyzer
JP2011510631A (en) * 2008-01-25 2011-04-07 ルミネックス コーポレーション Assay adjustment plate, a method of adjusting and analyzing adjustment and analysis system, as well as the assay of the fluid assay
KR20120032255A (en) * 2010-09-28 2012-04-05 삼성전자주식회사 Cell separation device and cell separation method using magnetic force
WO2012122536A3 (en) 2011-03-09 2012-11-22 Magarray, Inc. Systems and methods for high-throughput detection of an analyte in a sample
WO2014116813A1 (en) * 2013-01-25 2014-07-31 Douglas Scientific Silica-based biological material isolation
CN104087508B (en) * 2014-07-18 2016-04-13 东南大学 An electromagnetic biological sample processing apparatus
CN104263633B (en) * 2014-09-24 2015-12-09 东南大学 High throughput biological sample processing apparatus based on magnetic separation

Citations (12)

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US3569877A (en) * 1969-07-23 1971-03-09 Sperry Rand Corp High frequency switch
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4152210A (en) * 1971-08-27 1979-05-01 Beecham Group Limited Biologically active materials attached to a ferromagnetic support
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US5046468A (en) * 1989-07-27 1991-09-10 Prufrex-Elektro-Apparatebau Inh. Helga Muller, geb./Dutschke Method and system with inductive rotary emitter for the control especially of the ignition timing of internal combustion engines
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
US5647994A (en) * 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
US5921244A (en) * 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3569877A (en) * 1969-07-23 1971-03-09 Sperry Rand Corp High frequency switch
US4152210A (en) * 1971-08-27 1979-05-01 Beecham Group Limited Biologically active materials attached to a ferromagnetic support
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US5046468A (en) * 1989-07-27 1991-09-10 Prufrex-Elektro-Apparatebau Inh. Helga Muller, geb./Dutschke Method and system with inductive rotary emitter for the control especially of the ignition timing of internal combustion engines
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
US5647994A (en) * 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US5921244A (en) * 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALENGHAT F.J. ET AL.: 'Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer.' BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 277, 2000, pages 93 - 99, XP002988676 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9329194B2 (en) 2007-11-05 2016-05-03 Abbott Laboratories Automated analyzer for clinical laboratory

Also Published As

Publication number Publication date Type
WO2005059929A2 (en) 2005-06-30 application

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