WO2005054259A1 - Phosphinic acid derivatives - Google Patents
Phosphinic acid derivatives Download PDFInfo
- Publication number
- WO2005054259A1 WO2005054259A1 PCT/EP2004/013177 EP2004013177W WO2005054259A1 WO 2005054259 A1 WO2005054259 A1 WO 2005054259A1 EP 2004013177 W EP2004013177 W EP 2004013177W WO 2005054259 A1 WO2005054259 A1 WO 2005054259A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- hydroxy
- formula
- free base
- amino
- Prior art date
Links
- 0 C*1=CCCC1 Chemical compound C*1=CCCC1 0.000 description 4
- GKRJGWQQWVKCOC-UHFFFAOYSA-N CC1C2C(C)CCCC12 Chemical compound CC1C2C(C)CCCC12 GKRJGWQQWVKCOC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2004800343307A CN1882598B (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
DE602004025965T DE602004025965D1 (en) | 2003-11-21 | 2004-11-19 | Phosphinsäurederivate |
PL04819605T PL1687319T3 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
BRPI0416226-9A BRPI0416226A (en) | 2003-11-21 | 2004-11-19 | phosphonic acid derivatives |
US10/576,972 US7498319B2 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
AU2004295060A AU2004295060B2 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
JP2006540346A JP4478156B2 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
EP04819605A EP1687319B1 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
AT04819605T ATE460421T1 (en) | 2003-11-21 | 2004-11-19 | PHOSPHINIC ACID DERIVATIVES |
CA2545589A CA2545589C (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
MXPA06005704A MXPA06005704A (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0327186.3 | 2003-11-21 | ||
GBGB0327186.3A GB0327186D0 (en) | 2003-11-21 | 2003-11-21 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005054259A1 true WO2005054259A1 (en) | 2005-06-16 |
Family
ID=29764265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/013177 WO2005054259A1 (en) | 2003-11-21 | 2004-11-19 | Phosphinic acid derivatives |
Country Status (17)
Country | Link |
---|---|
US (1) | US7498319B2 (en) |
EP (1) | EP1687319B1 (en) |
JP (1) | JP4478156B2 (en) |
KR (1) | KR100807894B1 (en) |
CN (1) | CN1882598B (en) |
AT (1) | ATE460421T1 (en) |
AU (1) | AU2004295060B2 (en) |
BR (1) | BRPI0416226A (en) |
CA (1) | CA2545589C (en) |
DE (1) | DE602004025965D1 (en) |
ES (1) | ES2341254T3 (en) |
GB (1) | GB0327186D0 (en) |
MX (1) | MXPA06005704A (en) |
PL (1) | PL1687319T3 (en) |
PT (1) | PT1687319E (en) |
RU (1) | RU2368616C2 (en) |
WO (1) | WO2005054259A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109125331A (en) * | 2018-09-13 | 2019-01-04 | 大连医科大学附属第二医院 | GABABApplication of the receptor antagonist in terms of blocking the channel TREK-1 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0463560A1 (en) * | 1990-06-22 | 1992-01-02 | Ciba-Geigy Ag | New antiepileptic agents |
EP0543780A2 (en) * | 1991-11-21 | 1993-05-26 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU662404B2 (en) | 1992-05-08 | 1995-08-31 | Novartis Ag | Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids |
-
2003
- 2003-11-21 GB GBGB0327186.3A patent/GB0327186D0/en not_active Ceased
-
2004
- 2004-11-19 CA CA2545589A patent/CA2545589C/en not_active Expired - Fee Related
- 2004-11-19 KR KR1020067009807A patent/KR100807894B1/en not_active IP Right Cessation
- 2004-11-19 BR BRPI0416226-9A patent/BRPI0416226A/en not_active IP Right Cessation
- 2004-11-19 AU AU2004295060A patent/AU2004295060B2/en not_active Ceased
- 2004-11-19 ES ES04819605T patent/ES2341254T3/en active Active
- 2004-11-19 WO PCT/EP2004/013177 patent/WO2005054259A1/en active Application Filing
- 2004-11-19 JP JP2006540346A patent/JP4478156B2/en not_active Expired - Fee Related
- 2004-11-19 US US10/576,972 patent/US7498319B2/en not_active Expired - Fee Related
- 2004-11-19 EP EP04819605A patent/EP1687319B1/en not_active Not-in-force
- 2004-11-19 PT PT04819605T patent/PT1687319E/en unknown
- 2004-11-19 CN CN2004800343307A patent/CN1882598B/en not_active Expired - Fee Related
- 2004-11-19 AT AT04819605T patent/ATE460421T1/en active
- 2004-11-19 MX MXPA06005704A patent/MXPA06005704A/en active IP Right Grant
- 2004-11-19 RU RU2006121648/04A patent/RU2368616C2/en not_active IP Right Cessation
- 2004-11-19 PL PL04819605T patent/PL1687319T3/en unknown
- 2004-11-19 DE DE602004025965T patent/DE602004025965D1/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0463560A1 (en) * | 1990-06-22 | 1992-01-02 | Ciba-Geigy Ag | New antiepileptic agents |
EP0543780A2 (en) * | 1991-11-21 | 1993-05-26 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
Non-Patent Citations (1)
Title |
---|
ZANGER, M; GENNARO, A. R.: "Remington's Pharmaceutical Sciences", REMINGTON'S PHARMACEUTICAL SCIENCES, MACK PUBLISHING CO, US, 1975, pages 454 - 469, XP002320658 * |
Also Published As
Publication number | Publication date |
---|---|
BRPI0416226A (en) | 2007-01-02 |
CA2545589A1 (en) | 2005-06-16 |
DE602004025965D1 (en) | 2010-04-22 |
EP1687319A1 (en) | 2006-08-09 |
KR100807894B1 (en) | 2008-02-27 |
US20070259835A1 (en) | 2007-11-08 |
KR20060097037A (en) | 2006-09-13 |
US7498319B2 (en) | 2009-03-03 |
CN1882598B (en) | 2010-06-16 |
PL1687319T3 (en) | 2010-08-31 |
AU2004295060A1 (en) | 2005-06-16 |
RU2006121648A (en) | 2008-01-10 |
CN1882598A (en) | 2006-12-20 |
RU2368616C2 (en) | 2009-09-27 |
CA2545589C (en) | 2013-03-12 |
JP4478156B2 (en) | 2010-06-09 |
GB0327186D0 (en) | 2003-12-24 |
AU2004295060B2 (en) | 2007-08-30 |
JP2007513088A (en) | 2007-05-24 |
MXPA06005704A (en) | 2006-08-17 |
ES2341254T3 (en) | 2010-06-17 |
EP1687319B1 (en) | 2010-03-10 |
PT1687319E (en) | 2010-06-04 |
ATE460421T1 (en) | 2010-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101937496B1 (en) | Phosphorous derivatives as chemokine receptor modulators | |
EP0934326B1 (en) | Substituted aminoalkane phosphonic acids | |
DD255163A5 (en) | PROCESS FOR THE PREPARATION OF DIPHESPHENATES | |
KR20000067904A (en) | Phosphinate Based Inhibitors of Matrix Metalloproteases | |
EP0539057B1 (en) | Benzimidazole phosphono-amino acids | |
US5376684A (en) | Aminoalkanephosphinic acids and salts thereof | |
MXPA01006586A (en) | 1,1- and 1,2-disubstituted cyclopropane compounds. | |
CA2545589C (en) | Phosphinic acid derivatives | |
JPH08503229A (en) | 2-Substituted morpholine and thiomorpholine derivatives as GABA-B antagonists | |
US5710139A (en) | Heterocyclic compounds | |
CA2419279C (en) | Prodrugs to nmda receptor ligands | |
DE19754490A1 (en) | By an aminocarbonyl substituted bicyclic, their preparation and their use as medicaments | |
FI86849B (en) | FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA AZEPINONDERIVAT OCH VID FOERFARANDET ANVAENDBARA MELLANPRODUKTER. | |
AU2001285894A1 (en) | Prodrugs to NMDA receptor ligands | |
KR100636515B1 (en) | Novel type condensed pyridazinone compounds | |
US6518258B1 (en) | 6-sulphamoyl -3-quinolyphosphonic acid compounds | |
DE19545251A1 (en) | New quinoxalinedione derivatives, their production and use in pharmaceuticals | |
EP0279458A1 (en) | 2-Propyl amine derivatives, processes for their preparation and their use | |
FR2543553A1 (en) | Phosphonamide-LACTAMES | |
MXPA00006078A (en) | 1,4-diazacycloheptane derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200480034330.7 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004819605 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10576972 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004295060 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2545589 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020067009807 Country of ref document: KR Ref document number: PA/a/2006/005704 Country of ref document: MX Ref document number: 1778/CHENP/2006 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006540346 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: DE |
|
ENP | Entry into the national phase |
Ref document number: 2004295060 Country of ref document: AU Date of ref document: 20041119 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2004295060 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006121648 Country of ref document: RU |
|
WWP | Wipo information: published in national office |
Ref document number: 2004819605 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020067009807 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: PI0416226 Country of ref document: BR |
|
WWP | Wipo information: published in national office |
Ref document number: 10576972 Country of ref document: US |