WO2005052984A1 - Improvements in or relating to sift-ms instruments - Google Patents

Improvements in or relating to sift-ms instruments Download PDF

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Publication number
WO2005052984A1
WO2005052984A1 PCT/NZ2004/000297 NZ2004000297W WO2005052984A1 WO 2005052984 A1 WO2005052984 A1 WO 2005052984A1 NZ 2004000297 W NZ2004000297 W NZ 2004000297W WO 2005052984 A1 WO2005052984 A1 WO 2005052984A1
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WO
WIPO (PCT)
Prior art keywords
flow tube
instrument
quadrupole mass
mass filter
chamber
Prior art date
Application number
PCT/NZ2004/000297
Other languages
French (fr)
Inventor
Geoffrey Charles Peck
Original Assignee
Syft Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NZ52861703A external-priority patent/NZ528617A/en
Application filed by Syft Technologies Limited filed Critical Syft Technologies Limited
Priority to CA002546645A priority Critical patent/CA2546645A1/en
Priority to AU2004294054A priority patent/AU2004294054A1/en
Priority to EP04800216A priority patent/EP1695374A4/en
Priority to US10/580,355 priority patent/US7429730B2/en
Publication of WO2005052984A1 publication Critical patent/WO2005052984A1/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions

Definitions

  • the invention relates to an instrument that utilises selected ion flow tube (SIFT), or selected ion flow drift tube (SIFDT) technique which is a fast flow tube/ion swarm method for the study of positive or negative ions with atoms and molecules.
  • SIFT selected ion flow tube
  • SIFDT selected ion flow drift tube
  • a selected ion flow tube can either be a drift tube which has a potential gradient applied to it or a flow tube which has no gradient applied to it.
  • the general term flow tube is therefore intended to encompass both forms of technique, that is SIFT- MS and SIFDT-MS.
  • the ions are created in an ion source which is external to the flow tube.
  • the ions are then extracted from the ion source by a quadrupole mass filter which acts on the incident ion beam to create a pure species of ion beam (precursor).
  • An electrostatic lens is then used to focus the ion beam which is injected into one end of a flow tube or drift tube which has a flowing carrier gas, usually helium or a mixture of helium and argon or nitrogen.
  • the carrier gas is prevented from entering the quadrupole mass filter by being injected into the flow tube through a venturi orifice in a direction away from the orifice.
  • the flow tube or drift tube communicates via a downstream orifice with a downstream chamber housing a quadrupole mass spectrometer system where the ions are mass analysed and counted.
  • This form of instrument requires a chamber for the upstream quadrupole mass filter which is connected by the flow tube to a separate generally substantially identical chamber in which the downstream quadrupole mass spectrometer is housed.
  • the interiors of both the upstream and the downstream chambers are pressurised at a pressure generally of about 10 "6 Torr which is created by individual pumps.
  • the pressure in the flow tube is generally much greater than the pressure in the chambers and generally is in the order of 0.5 to 1.0 Torr. Because of the requirement of having separate chambers and because of the comparatively substantial size and capacity of the two pumps, a SIFT-MS or a SIFDT-MS instrument is of a substantial size.
  • the invention comprises an instrument for the analysis of volatile organic compounds including a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, and a curved flow tube connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
  • the instrument includes means associated with the chamber and connectable to an ion source to direct ions from the source to the upstream quadrupole mass filter to extract ions to create a precursor ion beam a lens to focus the ion beam and to inject the beam into a first end of the curved flow tube, means to enable a stream of non-reactive carrier gas to pass through the flow tube injection means through which the sample of the volatile organic compounds may be injected into the flow tube to react with the extracted ions, means to connect the second end of the flow tube to the downstream quadrupole mass filter through which the sample of charged ions are directed to a detector device.
  • an electrostatic shield is located in the chamber to shield the downstream quadrupole mass filter and detector from the upstream quadrupole mass filter and source introduction.
  • the non-reactive carrier gas is helium.
  • the non-reactive gas comprises a mixture of helium and other non- reactive gases.
  • the flow tube is pressurised at a higher pressure than that of the interior of the chamber.
  • the flow tube acts as a drift tube and has a potential gradient applied to it.
  • the flow tube acts as a flow tube and has no potential gradient applied to it.
  • a vacuum pump is utilised to ensure the non-reactive carrier gas will pass through the flow tube.
  • the injection of the non reactive gas into the flow tube is effected through a venturi orifice.
  • the curved flow tube and venturi orifice are constructed to provide a laminar flow of the gas-ion mixture through the flow tube.
  • the instrument for the analysis of volatile organic compounds includes a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, the interior of said chamber being divided into sections by an electrostatic screen to shield the downstream quadrupole mass filter and the detector from the upstream quadrupole mass filter and source introduction, and a flow tube comprising a straight tube and two bends connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
  • the interior of the chamber is evacuated by a pumping system that will maintain the internal elements within appropriate operating margins.
  • Figure 1 is a schematic diagram of a known form of SIFT-MS or SIFDT-MS instrument.
  • Figure 2 is a schematic diagram of the improved form of SIFT-MS or SIFDT-MS instrument according to the present invention.
  • a known form of SIFT-MS or SIFDT-MS instrument may comprise an upstream chamber 1 to which an ion source 2 is connected.
  • the upstream chamber houses a quadrupole mass filter 3 through which the ion stream is passed.
  • the upstream chamber is held at a pressure, generally 10 "6 Torr to enable correct operation of the quadrupole 3.
  • the ion stream is focused by the lens 4 before it passes through an ion injection orifice located as part of the venturi plate 8, to enter the flow tube 6.
  • the flow tube or flow drift tube 6 is generally held at a pressure of approximately 0.5 to 1.0 Torr and a stream of a non-reactive carrier gas or gas mixture, typically helium is injected at 8 into the flow tube in a manner that a venturi effect is obtained to prevent the ion stream from the chamber 1 and the non-reactive gas from escaping back into the upstream chamber. Additional non-reactive carrier gas or mixture of non-reactive gases, can be injected at additional points along tube 6.
  • the sample of the volatile organic compound (VOC) is injected at 7 into the flow tube and reacts with the incident beam of ions, the result of which is a transfer of ions to the VOC.
  • the charged VOCs then enter the downstream chamber through a small injection orifice 11 with the downstream chamber 10 generally held at a similar pressure (10 "6 Torr) to the upstream chamber 1.
  • the downstream chamber 10 is normally evacuated by means of a turbo pump 12 or similar.
  • the downstream chamber includes a set of lenses 13 and a quadrupole mass filter 14 with a detector device 15 by which the masses of the incident VOCs and precursor ions are measured.
  • Backing pumps are shown at 16 and these allow the chambers 1 and 10 to be evacuated sufficiently to allow turbo pumps 12 to maintain the desired chamber pressure.
  • flow tube is intended to include both a flow tube and a flow drift tube.
  • SIFT-MS or SIFDT-MS instrument is illustrated diagrammatically in
  • the upstream chamber 1 and the downstream chamber 10 of Figure 1 are dispensed with and a single combined chamber 20 is provided which is evacuated by a pumping system 21 preferably maintaining a pressure of 10 "5 Torr or lower.
  • the chamber 20 includes an upstream quadrupole 22 and lens 23 to extract the ions from the ion source 2 with the extracted ions being focused through the lens and injected into a flow tube or flow drift tube 24 through which a stream of non-reactive carrier gas is passed.
  • the flow tube or flow drift tube 24 is maintained at an appropriate pressure, typically 0.5 Torr by a pump 26.
  • the flow tube or flow drift tube 24 instead of being an essentially straight tube which connected an upstream chamber to a downstream chamber as in the case of the prior art instrument illustrated in Figure 1 , in the improvement provided by this invention, the flow tube or flow drift tube is curved as illustrated.
  • the sample VOCs are injected into the flow tube or flow drift tube 24 to react with the beam of ions which then enters the chamber 20 through an ion sampling orifice 25 where it is focused by the lens 28 into the quadrupole mass filter 29 which acts as a mass selector prior to analysis by the detector 15.
  • an electrostatic shield 27 may be located within the chamber 20 to electrostatically separate the quadrupole mass filter 22 and lens 23 from the lens 28 and quadrupole mass filter 29.
  • the purpose of the shield is to prevent both charged and uncharged particles from creating interferences between the ion source 2 and the quadrupole mass filters 29, 22 and the detector 15.
  • shield purpose of the shield is to act as a barrier which is impermeable to ions or energetic particles and the term electrostatic shield is therefore intended to encompass all forms of shields or barriers capable of preventing interference between the ion source and the quadrupole filters and detector.
  • the pump 21 must be chosen to ensure both sides of the shielded chamber are adequately pumped to allow the quadrupole mass filters 22 and 29 and also the detector to operate within their required ranges. It will be understood that if the shield is constructed from a metal grid or gauze, then the pumping will be arranged to take into account the possible permeability of the shields. Backing pumps are shown at 26 and these allow the chamber 20 to be evacuated sufficiently to allow the pumping system 21 to maintain the desired chamber pressure. As in the case of the instrument illustrated in Figure 1 , a non-reactive gas such as helium and the precursor ions are injected into one end of the flow tube and flow along the tube, the flow being created by the action of the vacuum pump. It is therefore possible to maintain laminar flow after injection of the sample VOCs.
  • the non-reactive gas may also be a mixture of helium and argon or nitrogen or a mixture of helium and other suitable non- reactive gas or gases.

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A SIFT or SIFDT apparatus in which the upstream quadrupole and the downstream quadrupole are housed within a single evacuated chamber (20) with the upstream quadrupole (22) being connected to the downstream quadrupole (29) by a curved flow tube (24). In a preferred form the interior of the chamber is divided into sections by an electrostatic shield (27) which shields the upstream quadrupole and source connection from the downstream quadrupole and detector.

Description

Improvements in or relating to SIFT-MS instruments
Background to the invention In particular the invention relates to an instrument that utilises selected ion flow tube (SIFT), or selected ion flow drift tube (SIFDT) technique which is a fast flow tube/ion swarm method for the study of positive or negative ions with atoms and molecules. A selected ion flow tube can either be a drift tube which has a potential gradient applied to it or a flow tube which has no gradient applied to it. In the following description, the general term flow tube is therefore intended to encompass both forms of technique, that is SIFT- MS and SIFDT-MS.
In SIFT and SIFDT apparatus, the ions are created in an ion source which is external to the flow tube. The ions are then extracted from the ion source by a quadrupole mass filter which acts on the incident ion beam to create a pure species of ion beam (precursor). An electrostatic lens is then used to focus the ion beam which is injected into one end of a flow tube or drift tube which has a flowing carrier gas, usually helium or a mixture of helium and argon or nitrogen. The carrier gas is prevented from entering the quadrupole mass filter by being injected into the flow tube through a venturi orifice in a direction away from the orifice. This enables the swarm of single ion species to be thermalised in a flow tube at the same temperature as the carrier gas flows along the flow tube and quickly establishes a laminar flow of gases through the flow tube. The flow tube or drift tube communicates via a downstream orifice with a downstream chamber housing a quadrupole mass spectrometer system where the ions are mass analysed and counted.
This form of instrument requires a chamber for the upstream quadrupole mass filter which is connected by the flow tube to a separate generally substantially identical chamber in which the downstream quadrupole mass spectrometer is housed. To allow the quadrupole mass filters to operate effectively, the interiors of both the upstream and the downstream chambers are pressurised at a pressure generally of about 10"6 Torr which is created by individual pumps. The pressure in the flow tube is generally much greater than the pressure in the chambers and generally is in the order of 0.5 to 1.0 Torr. Because of the requirement of having separate chambers and because of the comparatively substantial size and capacity of the two pumps, a SIFT-MS or a SIFDT-MS instrument is of a substantial size. In addition because of the type of the pumps needed, considerable noise can be created when the instrument is operating. If the instrument is to be made at all portable, it is highly desirable that the instrument including the pumps be housed within a suitably small structure and because of the size and capacity of the pumps it is necessary that considerable attention also be given to adequate sound deadening.
Object of the invention It is therefore an object of this invention to provide an improved instrument for analysis of volatile organic chemicals and which has a flow tube which utilises SIFT-MS or SIFDT-MS technique.
It is a further object of this invention to provide a SIFT-MS or SIFDT-MS instrument which can be more transportable than previously known instruments and in which the size and combined weight of the various components of the instrument, particularly the high pressure pumps can be downsized from that previously known.
Disclosure of the invention Accordingly in one form the invention comprises an instrument for the analysis of volatile organic compounds including a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, and a curved flow tube connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
Preferably the instrument includes means associated with the chamber and connectable to an ion source to direct ions from the source to the upstream quadrupole mass filter to extract ions to create a precursor ion beam a lens to focus the ion beam and to inject the beam into a first end of the curved flow tube, means to enable a stream of non-reactive carrier gas to pass through the flow tube injection means through which the sample of the volatile organic compounds may be injected into the flow tube to react with the extracted ions, means to connect the second end of the flow tube to the downstream quadrupole mass filter through which the sample of charged ions are directed to a detector device.
Preferably an electrostatic shield is located in the chamber to shield the downstream quadrupole mass filter and detector from the upstream quadrupole mass filter and source introduction.
Preferably the non-reactive carrier gas is helium. Preferably the non-reactive gas comprises a mixture of helium and other non- reactive gases.
Preferably the flow tube is pressurised at a higher pressure than that of the interior of the chamber.
Preferably the flow tube acts as a drift tube and has a potential gradient applied to it.
Preferably the flow tube acts as a flow tube and has no potential gradient applied to it.
Preferably a vacuum pump is utilised to ensure the non-reactive carrier gas will pass through the flow tube. Preferably the injection of the non reactive gas into the flow tube is effected through a venturi orifice. Preferably the curved flow tube and venturi orifice are constructed to provide a laminar flow of the gas-ion mixture through the flow tube.
In another aspect the instrument for the analysis of volatile organic compounds includes a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, the interior of said chamber being divided into sections by an electrostatic screen to shield the downstream quadrupole mass filter and the detector from the upstream quadrupole mass filter and source introduction, and a flow tube comprising a straight tube and two bends connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
Preferably the interior of the chamber is evacuated by a pumping system that will maintain the internal elements within appropriate operating margins.
Brief description of the drawings Figure 1 is a schematic diagram of a known form of SIFT-MS or SIFDT-MS instrument.
Figure 2 is a schematic diagram of the improved form of SIFT-MS or SIFDT-MS instrument according to the present invention.
Description of the preferred embodiments of the invention. As illustrated in Figure 1 , a known form of SIFT-MS or SIFDT-MS instrument may comprise an upstream chamber 1 to which an ion source 2 is connected. The upstream chamber houses a quadrupole mass filter 3 through which the ion stream is passed. The upstream chamber is held at a pressure, generally 10"6 Torr to enable correct operation of the quadrupole 3. The ion stream is focused by the lens 4 before it passes through an ion injection orifice located as part of the venturi plate 8, to enter the flow tube 6.
The flow tube or flow drift tube 6 is generally held at a pressure of approximately 0.5 to 1.0 Torr and a stream of a non-reactive carrier gas or gas mixture, typically helium is injected at 8 into the flow tube in a manner that a venturi effect is obtained to prevent the ion stream from the chamber 1 and the non-reactive gas from escaping back into the upstream chamber. Additional non-reactive carrier gas or mixture of non-reactive gases, can be injected at additional points along tube 6.
The sample of the volatile organic compound (VOC) is injected at 7 into the flow tube and reacts with the incident beam of ions, the result of which is a transfer of ions to the VOC. The charged VOCs then enter the downstream chamber through a small injection orifice 11 with the downstream chamber 10 generally held at a similar pressure (10"6 Torr) to the upstream chamber 1. As in the case of the upstream chamber, the downstream chamber 10 is normally evacuated by means of a turbo pump 12 or similar. The downstream chamber includes a set of lenses 13 and a quadrupole mass filter 14 with a detector device 15 by which the masses of the incident VOCs and precursor ions are measured. Backing pumps are shown at 16 and these allow the chambers 1 and 10 to be evacuated sufficiently to allow turbo pumps 12 to maintain the desired chamber pressure.
In the following description and claims the term "flow tube' is intended to include both a flow tube and a flow drift tube. The improved SIFT-MS or SIFDT-MS instrument is illustrated diagrammatically in
Figure 2. As illustrated, the upstream chamber 1 and the downstream chamber 10 of Figure 1 are dispensed with and a single combined chamber 20 is provided which is evacuated by a pumping system 21 preferably maintaining a pressure of 10"5 Torr or lower. The chamber 20 includes an upstream quadrupole 22 and lens 23 to extract the ions from the ion source 2 with the extracted ions being focused through the lens and injected into a flow tube or flow drift tube 24 through which a stream of non-reactive carrier gas is passed. The flow tube or flow drift tube 24 is maintained at an appropriate pressure, typically 0.5 Torr by a pump 26. The flow tube or flow drift tube 24 instead of being an essentially straight tube which connected an upstream chamber to a downstream chamber as in the case of the prior art instrument illustrated in Figure 1 , in the improvement provided by this invention, the flow tube or flow drift tube is curved as illustrated. The sample VOCs are injected into the flow tube or flow drift tube 24 to react with the beam of ions which then enters the chamber 20 through an ion sampling orifice 25 where it is focused by the lens 28 into the quadrupole mass filter 29 which acts as a mass selector prior to analysis by the detector 15.
Depending on the source of ions and the construction of the chamber various undesired particles may enter the chamber and depending upon the type of particles it can be necessary to insert an electrostatic shield in the chamber to block these particles from reaching the detector. As illustrated in Figure 2, an electrostatic shield 27 may be located within the chamber 20 to electrostatically separate the quadrupole mass filter 22 and lens 23 from the lens 28 and quadrupole mass filter 29. The purpose of the shield is to prevent both charged and uncharged particles from creating interferences between the ion source 2 and the quadrupole mass filters 29, 22 and the detector 15. It is to be understood that purpose of the shield is to act as a barrier which is impermeable to ions or energetic particles and the term electrostatic shield is therefore intended to encompass all forms of shields or barriers capable of preventing interference between the ion source and the quadrupole filters and detector.
The pump 21 must be chosen to ensure both sides of the shielded chamber are adequately pumped to allow the quadrupole mass filters 22 and 29 and also the detector to operate within their required ranges. It will be understood that if the shield is constructed from a metal grid or gauze, then the pumping will be arranged to take into account the possible permeability of the shields. Backing pumps are shown at 26 and these allow the chamber 20 to be evacuated sufficiently to allow the pumping system 21 to maintain the desired chamber pressure. As in the case of the instrument illustrated in Figure 1 , a non-reactive gas such as helium and the precursor ions are injected into one end of the flow tube and flow along the tube, the flow being created by the action of the vacuum pump. It is therefore possible to maintain laminar flow after injection of the sample VOCs. The non-reactive gas may also be a mixture of helium and argon or nitrogen or a mixture of helium and other suitable non- reactive gas or gases.
Because of the improvements in the instrument brought about by the present invention, it is possible to make the whole instrument considerably physically smaller with less componentry that that previously required. This provides significant savings in the cost in the manufacture of the instrument. In addition, because only a single pump is used, less electrical power is required and less noise is generated. This reduces the considerable amount of sound insulation that was previously required. It is to be understood this is a major advantage when constructing the instrument as a portable instrument because this will result in a reduction of the number of component parts and consequently in the size of the machine and in the weight of the machine
Having described the preferred embodiments of the invention it will be apparent to those skilled in the art that various changes and alterations can be made to the embodiments and yet still come within the general concept of the invention. All such changes and alterations are intended to be included in the scope of this specification

Claims

1. An instrument for the analysis of volatile organic compounds including a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, and a curved flow tube connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
2. The instrument as claimed in claim 1 , including means associated with the chamber and connectable to an ion source to direct ions from the source to the upstream quadrupole mass filter to extract ions to create a precursor ion beam a lens to focus the ion beam and to inject the beam into a first end of the curved flow tube, means to enable a stream of non-reactive carrier gas to pass through the flow tube injection means through which the sample of the volatile organic compounds may be injected into the flow tube to react with the extracted ions, means to connect the second end of the flow tube to the downstream quadrupole mass filter through which the sample of charged ions are directed to a detector device.
3. The instrument as claimed in claim 1 , including an electrostatic shield located in the chamber to shield the downstream quadrupole mass filter and detector from the upstream quadrupole mass filter and source introduction.
4. The instrument as claimed in claim 1, wherein the non-reactive carrier gas is helium.
5. The instrument as claimed in claim 1 , wherein the non-reactive gas comprises a mixture of helium and other non-reactive gases.
6. The instrument as claimed in claim 1 , wherein the flow tube is pressurised at a higher pressure than that of the interior of the chamber.
7. The instrument as claimed in claim 1 , wherein the flow tube acts as a drift tube and has a potential gradient applied to it.
8. The instrument as claimed in claim 1 , wherein the flow tube acts as a flow tube and has no potential gradient applied to it.
9. The instrument as claimed in claim 1 , wherein a vacuum pump is utilised to ensure the non-reactive carrier gas will pass through the flow tube.
10. The instrument as claimed in claim 1 , wherein the injection of the non reactive gas into the flow tube is effected through a venturi orifice.
11. The instrument as claimed in claim 10, wherein the curved flow tube and venturi orifice are constructed to provide a laminar flow of the gas-ion mixture through the flow tube.
12. An instrument for the analysis of volatile organic compounds, said instrument including a downstream quadrupole mass filter and an upstream quadrupole mass filter housed within an evacuated chamber, the interior of said chamber being divided into sections by an electrostatic screen to shield the downstream quadrupole mass filter and the detector from the upstream quadrupole mass filter and source introduction, and a flow tube comprising a straight tube and two bends connecting the upstream quadrupole mass filter to the downstream quadrupole mass filter.
13. The instrument as claimed in claim 1 wherein the interior of the chamber is evacuated by a pumping system that will maintain the internal elements within appropriate operating margins.
PCT/NZ2004/000297 2003-11-25 2004-11-24 Improvements in or relating to sift-ms instruments WO2005052984A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002546645A CA2546645A1 (en) 2003-11-25 2004-11-24 Improvements in or relating to sift-ms instruments
AU2004294054A AU2004294054A1 (en) 2003-11-25 2004-11-24 Improvements in or relating to SIFT-MS instruments
EP04800216A EP1695374A4 (en) 2003-11-25 2004-11-24 Improvements in or relating to sift-ms instruments
US10/580,355 US7429730B2 (en) 2003-11-25 2004-11-24 SIFT-MS instruments

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ528617 2003-11-25
NZ52861703A NZ528617A (en) 2003-11-25 2003-11-25 A compact SIFT-MS instruments using a downstream and an upstream mass filters housed in an evacuated chamber
NZ531103 2004-02-12
NZ53110304 2004-02-12

Publications (1)

Publication Number Publication Date
WO2005052984A1 true WO2005052984A1 (en) 2005-06-09

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US (1) US7429730B2 (en)
EP (1) EP1695374A4 (en)
AU (1) AU2004294054A1 (en)
CA (1) CA2546645A1 (en)
WO (1) WO2005052984A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110024614A1 (en) * 2006-10-19 2011-02-03 Syft Technologies Limited Sift-ms instrument
CN105719941A (en) * 2014-12-05 2016-06-29 中国科学院大连化学物理研究所 Flight time mass spectrum detector for high dynamic measurement scope

Citations (3)

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EP0237259A2 (en) * 1986-03-07 1987-09-16 Finnigan Corporation Mass spectrometer
US5202563A (en) * 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument

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US5559317A (en) * 1995-03-27 1996-09-24 International Verifact Inc. Card reader with carriage powered by movement of inserted card

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Publication number Priority date Publication date Assignee Title
EP0237259A2 (en) * 1986-03-07 1987-09-16 Finnigan Corporation Mass spectrometer
US5202563A (en) * 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1695374A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110024614A1 (en) * 2006-10-19 2011-02-03 Syft Technologies Limited Sift-ms instrument
CN105719941A (en) * 2014-12-05 2016-06-29 中国科学院大连化学物理研究所 Flight time mass spectrum detector for high dynamic measurement scope
CN105719941B (en) * 2014-12-05 2019-07-19 中国科学院大连化学物理研究所 A kind of flight time mass spectrum detector of high dynamic measurement range

Also Published As

Publication number Publication date
US7429730B2 (en) 2008-09-30
CA2546645A1 (en) 2005-06-09
US20080078929A1 (en) 2008-04-03
AU2004294054A1 (en) 2005-06-09
EP1695374A1 (en) 2006-08-30
EP1695374A4 (en) 2008-04-16

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