WO2005046575A3 - Amino acid prodrugs - Google Patents

Amino acid prodrugs Download PDF

Info

Publication number
WO2005046575A3
WO2005046575A3 PCT/US2004/024901 US2004024901W WO2005046575A3 WO 2005046575 A3 WO2005046575 A3 WO 2005046575A3 US 2004024901 W US2004024901 W US 2004024901W WO 2005046575 A3 WO2005046575 A3 WO 2005046575A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
present invention
drug
directed
prodrug
Prior art date
Application number
PCT/US2004/024901
Other languages
French (fr)
Other versions
WO2005046575A2 (en
Inventor
V Ravi Chandran
Original Assignee
Signature R & D Holdings Lcc
V Ravi Chandran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US49133103P priority Critical
Priority to US60/491,331 priority
Application filed by Signature R & D Holdings Lcc, V Ravi Chandran filed Critical Signature R & D Holdings Lcc
Publication of WO2005046575A2 publication Critical patent/WO2005046575A2/en
Priority claimed from US11/343,557 external-priority patent/US8173840B2/en
Priority claimed from US11/442,027 external-priority patent/US7589233B2/en
Publication of WO2005046575A3 publication Critical patent/WO2005046575A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • C07K7/645Cyclosporins; Related peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/38Medical treatment of vector-borne diseases characterised by the agent
    • Y02A50/408Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa
    • Y02A50/411Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a protozoa of the genus Plasmodium, i.e. Malaria

Abstract

The present invention is directed to a prodrug comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. The prodrug has the same utility as the drug from which it is made, but it has enhanced therapeutic properties. In fact, the prodrugs of the present invention enhance at least two therapeutic qualities, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.
PCT/US2004/024901 2003-07-29 2004-07-29 Amino acid prodrugs WO2005046575A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US49133103P true 2003-07-29 2003-07-29
US60/491,331 2003-07-29

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP2006522125A JP2007510621A (en) 2003-07-29 2004-07-29 Amino acid prodrugs
NZ545570A NZ545570A (en) 2003-07-29 2004-07-29 Amino acid prodrugs
CA2534342A CA2534342C (en) 2003-07-29 2004-07-29 Amino acid prodrugs
EP04816791A EP1660017A4 (en) 2003-07-29 2004-07-29 Amino acid prodrugs
AU2004289174A AU2004289174B2 (en) 2003-07-29 2004-07-29 Amino acid prodrugs
KR1020137015399A KR20130081319A (en) 2003-07-29 2004-07-29 Amino acid prodrugs
IL173382A IL173382D0 (en) 2003-07-29 2006-01-26 Amino acid prodrugs
US11/343,557 US8173840B2 (en) 2003-07-29 2006-01-30 Compounds with high therapeutic index
US11/442,027 US7589233B2 (en) 2003-07-29 2006-05-26 L-Threonine derivatives of high therapeutic index
US12/557,030 US8188311B2 (en) 2003-07-29 2009-09-10 L-threonine derivatives of high therapeutic index
US12/557,080 US20100069489A1 (en) 2003-07-29 2009-09-10 L-threonine derivatives of high therapeutic index
US12/556,968 US8563776B2 (en) 2003-07-29 2009-09-10 L-Threonine derivatives of high therapeutic index
US13/449,791 US20120289471A1 (en) 2003-07-29 2012-04-18 Novel compounds with high therapeutic index

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/343,557 Continuation-In-Part US8173840B2 (en) 2003-07-29 2006-01-30 Compounds with high therapeutic index

Publications (2)

Publication Number Publication Date
WO2005046575A2 WO2005046575A2 (en) 2005-05-26
WO2005046575A3 true WO2005046575A3 (en) 2007-10-04

Family

ID=34590076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/024901 WO2005046575A2 (en) 2003-07-29 2004-07-29 Amino acid prodrugs

Country Status (11)

Country Link
EP (1) EP1660017A4 (en)
JP (2) JP2007510621A (en)
KR (3) KR20060073584A (en)
CN (1) CN101123878A (en)
AU (1) AU2004289174B2 (en)
CA (1) CA2534342C (en)
IL (1) IL173382D0 (en)
NZ (3) NZ545570A (en)
SG (2) SG178721A1 (en)
WO (1) WO2005046575A2 (en)
ZA (1) ZA200600660B (en)

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Also Published As

Publication number Publication date
EP1660017A4 (en) 2011-03-09
CA2534342A1 (en) 2005-05-26
KR20060073584A (en) 2006-06-28
NZ601772A (en) 2012-10-26
SG145693A1 (en) 2008-09-29
JP2013035863A (en) 2013-02-21
NZ545570A (en) 2012-07-27
EP1660017A2 (en) 2006-05-31
KR20130081319A (en) 2013-07-16
AU2004289174B2 (en) 2011-05-19
AU2004289174A2 (en) 2005-05-26
NZ601780A (en) 2012-10-26
CN101123878A (en) 2008-02-13
CA2534342C (en) 2016-05-10
AU2004289174A1 (en) 2005-05-26
IL173382D0 (en) 2006-06-11
KR20120116991A (en) 2012-10-23
SG178721A1 (en) 2012-03-29
ZA200600660B (en) 2007-04-25
WO2005046575A2 (en) 2005-05-26
JP2007510621A (en) 2007-04-26

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