WO2005045038A3 - RNA interference mediated inhibition of GPRA and AAA1 gene expression using short nucleic acid (siNA) - Google Patents

RNA interference mediated inhibition of GPRA and AAA1 gene expression using short nucleic acid (siNA) Download PDF

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Publication number
WO2005045038A3
WO2005045038A3 PCT/US2004/027231 US2004027231W WO2005045038A3 WO 2005045038 A3 WO2005045038 A3 WO 2005045038A3 US 2004027231 W US2004027231 W US 2004027231W WO 2005045038 A3 WO2005045038 A3 WO 2005045038A3
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WIPO (PCT)
Prior art keywords
nucleic acid
gpra
sina
rna
aaa1
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PCT/US2004/027231
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French (fr)
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WO2005045038A8 (en
WO2005045038A2 (en
Inventor
Ivan Richards
Barry Polisky
James Mcswiggen
Original Assignee
Ivan Richards
Barry Polisky
James Mcswiggen
Sirna Therapeutics Inc
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Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/en
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/en
Priority to EP04781836A priority Critical patent/EP1694838A2/en
Application filed by Ivan Richards, Barry Polisky, James Mcswiggen, Sirna Therapeutics Inc filed Critical Ivan Richards
Priority to CA002543029A priority patent/CA2543029A1/en
Priority to JP2006536611A priority patent/JP2007527709A/en
Publication of WO2005045038A2 publication Critical patent/WO2005045038A2/en
Publication of WO2005045038A8 publication Critical patent/WO2005045038A8/en
Publication of WO2005045038A3 publication Critical patent/WO2005045038A3/en

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Abstract

This invention relates to compounds, compositions, and methods useful for modulating G protein-coupled receptor for asthma susceptibility (GPRA) and asthma-associated alternatively spliced gene 1 (AAA1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GPRA and/or AAA1 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GPRA and/or AAA1 genes.
PCT/US2004/027231 2003-10-23 2004-08-20 RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA) WO2005045038A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006536611A JP2007527709A (en) 2003-10-23 2004-08-20 Inhibition of GPRA and / or AAA1 gene expression via RNA interference using short interfering nucleic acids (siNA)
CA002543029A CA2543029A1 (en) 2003-10-23 2004-08-20 Rna interference mediated inhibition of gpra and aaa1 gene expression using short nucleic acid (sina)
EP04781836A EP1694838A2 (en) 2003-10-23 2004-08-20 RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/693,059 2003-10-23
US10/720,448 2003-11-24
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/727,780 2003-12-03
US10/757,803 2004-01-14
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/780,447 2004-02-13
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US10/826,966 2004-04-16
USPCT/US04/13456 2004-04-30
PCT/US2004/013456 WO2005041859A2 (en) 2003-04-30 2004-04-30 Conjugates and compositions for cellular delivery.
US57008604P 2004-05-11 2004-05-11
US60/570,086 2004-05-11
PCT/US2004/016390 WO2005019453A2 (en) 2001-05-18 2004-05-24 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
USPCT/US04/16390 2004-05-24

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