WO2005044250A1 - Use of sulfonamide compounds for the treatment of diabetes and/or obesity - Google Patents
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- WO2005044250A1 WO2005044250A1 PCT/GB2004/004582 GB2004004582W WO2005044250A1 WO 2005044250 A1 WO2005044250 A1 WO 2005044250A1 GB 2004004582 W GB2004004582 W GB 2004004582W WO 2005044250 A1 WO2005044250 A1 WO 2005044250A1
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- methylethyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to a novel use of sulphonamide compounds of Formula (I) as inhibitors of both acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransf erase and acetyl Co A: cholesterol acyl transferase and to their use in the treatment of type II diabetes, insulin resistance, impaired glucose tolerance and obesity.
- a key enzyme in triglyceride synthesis is acyl CoA:diacylglycerol acyltransferase (DGAT), which is found in the microsomal fraction of cells. DGAT catalyzes the final reaction in the glycerol phosphate pathway, considered to be the main pathway of triglyceride synthesis in cells.
- the enzyme is also believed to catalyze the final step of the monoacylglycerol pathway, found predominantly in enterocytes of the small intestine.
- DGAT facilitates the joining of a diacylglycerol with a fatty acyl Co A, resulting in the formation of triglyceride.
- DGAT is rate-limiting for triglyceride synthesis, it catalyzes the only step in the pathway that is committed to producing this type of molecule [Lehner & Kuksis (1996) Biosynthesis of triacylglycerols. Prog. Lipid Res. 35: 169-201].
- DGAT gene was identified from sequence database searches because of its similarity to acyl CoA: cholesterol acyltransferase (ACAT) genes.
- ACAT cholesterol acyltransferase
- DGAT is active in both skeletal and heart muscle, where triglycerides serve as stores of fatty acids for oxidative metabolism. Because of the previous lack of molecular probes, little is known about the regulation of DGAT. DGAT is known to be significantly up-regulated during adipocyte differentiation. As DGAT acts at an important branch point in the glycerolipid synthetic pathway, its activity may also be regulated in accordance with the metabolic state of the cell. Several studies have reported that hormones influence DGAT activity and the enzyme may be post-translationally regulated by a tyrosine kinase. Studies in gene knockout mice has indicated that modulators of the activity of DGAT would be of value in the treatment of type II diabetes and obesity.
- DGAT knockout mice are viable and capable of synthesizing triglycerides, as evidenced by normal fasting serum triglyceride levels and normal adipose tissue composition.
- Dgaf 1' mice have less adipose tissue than wild-type mice at baseline and are resistant to diet-induced obesity. This is not due to decreased caloric intake in these animals.
- metabolic rate is -20% higher in Dgaf 1' mice than in wild-type mice on both regular and high-fat diets [Smith et al (2000) Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT. Nature Genetics 25: 87-90].
- Dgaf 1' mice Increased physical activity in Dgaf 1' mice partially accounts for their increased energy expenditure.
- the Dgaf ' mice also exhibit increased insulin sensitivity and a 20% increase in glucose disposal rate.
- Leptin levels are 50% decreased in the Dgaf 1' mice in line with the 50% decrease in fat mass.
- ob/ob mice When Dgaf 1' mice are crossed with ob/ob mice, these mice exhibit the ob/ob phenotype [Chen et al (2002) Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase J. Clin. Invest. 109:1049-1055].
- DGAT2 One member of this family, DGAT2, has been cloned and characterised [Cases et al (2001) Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 276:38870- 38876.]. DGAT2 has no sequence homology with DGAT1 but shares some homology with the monoacylglycerol acyltransferase (MGAT) family [Yen et al (2002) Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc. Natl. Acad. Sci. USA 99:8512-8517].
- MGAT monoacylglycerol acyltransferase
- the two DGATs exhibit different sensitivities to MgCl 2 .
- Over-expression of DGAT2 in insect cells results in large increases in triglyceride synthesis from oleoyl CoA and diacylglycerol.
- DGAT1 and 2 have similar maximal capacities for triglyceride synthesis and have similar fatty acyl CoA specificities.
- the relative contribution of the various DGATs to triglyceride synthesis in adipose and other tissues remains to be determined although the residual activity in Dgaf 1' tissues (DGAT17 ) is relatively low even when low MgCl 2 concentrations are used. Recent evidence suggests that the overt DGAT activity found in hepatocytes is associated with DGAT2.
- Acyl-CoA cholesterol acyltransferase (ACAT) enzymes catalyze the synthesis of cholesterol esters from free cholesterol and fatty acyl-CoAs thereby participating in regulating the concentration of cellular free sterols.
- ACAT cholesterol acyltransferase
- the cholesterol ester products of ACAT reactions can be stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of these droplets results in the formation of ⁇ foam cells', a hallmark of early atherosclerotic lesions [Brown & Goldstein (1983) Annu. Rev. Biochem. 52:223-261.].
- ACAT2 The cloning of ACATl led to the identification of a second ACAT gene, ACAT2 [Anderson et ⁇ .(1998) Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273: 26747-26754; Cases et ⁇ /.(1998) ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterisation. J. Biol. Chem.
- ACATl has many hydrophobic regions, consistent with it being an integral membrane protein. Most of the seven transmembrane domains have sequences that are highly conserved among other ACAT enzymes. As these regions are not conserved in DGAT enzymes, it has been hypothesized that these regions bind cholesterol in the membrane. ACATl mRNA is expressed ubiquitously in mammalian tissues.
- ACATl expression levels of ACATl are highest in the adrenal glands, macrophages, and sebaceous glands; and in humans is also detectable in liver and intestinal epithelial cells. ACATl expression has also been detected in human atherosclerotic lesions. ACATl appears to be regulated primarily by posttranslational mechanisms and is allosterically activated by the binding of cholesterol or oxysterols. The ACAT2 cDNA encodes a protein with greater than 40% identity to human ACATl. ACAT2 is also a hydrophobic protein with multiple transmembrane domains. ACAT activity is found primarily in the endoplasmic reticulum.
- ACAT2 The active site for ACAT2 is located on the luminal side of the endoplasmic reticulum membrane, whereas the active site for ACATl is oriented toward the cytosol.
- the ACAT2 sequence contains many of the same motifs found in ACATl.
- ACAT2 is expressed primarily in the liver and small intestine. In humans, nonhuman primates and mice, ACAT2 appears to be the major ACAT in the small intestine. ACAT2 also appears to be the predominant ACAT expressed in the liver of adult nonhuman primates and mice.
- International patent application, publication number, WO 94/26702 describes a group of sulphonamide compounds, as ACAT inhibitors, with utility in the treatment of hypercholesterolemia and atherosclerosis. We have surprisingly found that these compounds are also inhibitors of DGAT and thus of utility in the treatment of type II diabetes and obesity.
- X and Y are independently selected from: oxygen, sulphur and (-CR a R b -) n ; wherein: n is an integer of from 1 to 4 and R a and R b are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo, hydroxy, C 1- alkanoyloxy, C 3-12 cycloalkyl and optionally substituted phenyl or R a and R b together form a C 5-12 spirocycIoalkyI or a carbonyl; with the proviso that at least one of X and Y is (-CR a R -) n and with the further proviso that when X and Y are both (-CR a R b -) n and R a and R b are hydrogen and n is 1, then R 1 and R 3 are both aryl;
- R 1 and R 3 are independently selected from (a) phenyl or phenoxy wherein the phenyl or phenoxy group is optionally substituted with 1 to 5 substituents independently selected from phenyl, C 1-6 alkyl, C 1-6 alkoxy, phenoxy, hydroxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, carboxy, C 1- a ⁇ koxycarbony and -(CH 2 ) P NR 4 R 5 wherein p is 0 or 1, and R 4 and R 5 are independently selected from hydrogen or C 1- alkyl;
- R is hydrogen, a C 1-8 alkyl or benzyl; or pharmaceutically acceptable salt, pro-drug or solvate thereof in the manufacture of a medicament for the treatment of type II diabetes and/or obesity.
- R 1 be optionally substituted phenoxy
- Y is (-CR a R b -) n
- R 3 be optionally substituted phenoxy.
- a method of treatment, in a warm-blooded animal, of type II diabetes and/or obesity comprising the administration of a therapeutically (including prophylactically) effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, pro-drug or solvate thereof.
- a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically effective salt, pro-drug or solvate thereof , in admixture with a pharmaceutically acceptable diluent or carrier for the treatment of type LI diabetes and/or obesity.
- a compound of Formula (I) in the manufacture of a medicament for the inhibition of both acetyl CoA(acetyl coenzyme A): diacylglycerol acyltransferase and acetyl CoA:cholesterol acyl transferase.
- a method of treatment in a warm-blooded animal, by the inhibition of both acetyl CoA(acetyl coenzyme A): diacylglycerol acyltransferase and acetyl CoA:cholesterol acyl transferase comprising the administration of a therapeutically (including prophylactically) effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt, pro-drug or solvate thereof.
- a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically effective salt, pro-drug or solvate thereof , in admixture with a pharmaceutically acceptable diluent or carrier for the inhibition of both acetyl CoA(acetyl coenzyme A): diacylglycerol acyltransferase and acetyl CoA:cholesterol acyl transferase.
- acetyl CoA acetyl coenzyme A
- diacylglycerol acyltransferase acetyl CoA:cholesterol acyl transferase.
- an alkyl group is a saturated chain having 1 to 20 carbon atoms which may be linear or branched.
- alkyl groups include: methyl, ethyl, n-propyl, isopropyl, n-butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl, n-hexyl, n-heptyl, n-octyl, n-undecyl, n-dodecyl, n-hexadecyl, 2,2- dimethyldodecyl, 2-tetradecyl, and n-octadecyl groups.
- alkenyl refers to a carbon chain having 1 to 20 carbon atoms having from 1 to 3 double bonds.
- alkenyl examples include: ethenyl, 2-propenyl, 2-butenyl, 3-pentenyl, 2-octenyl, 5-nonenyl, 4-undecenyl, 5-heptadecenyl, 3-octadecenyl, 9-octadecenyl, 2,2- dimethyl-11-eicosenyl, 9,12-octadecadienyl, and hexadecenyl.
- aryl refers to phenyl or naphthyl.
- halo refers to fluoro, chloro, bromo or iodo.
- cycloalkyl refers to a saturated carbocyclic ring containing between 3 and
- cycloalkyl examples include: cyclopentyl, cyclohexyl, cyclooctyl, tetrahydronaphthyl, adamant-1-yl and adamant-2-yl.
- spirocycloalkyl refers to bicyclic saturated carbon rings containing between 5 and 12 carbon atoms wherein one carbon atom is common to both rings, Examples of spirocycloalkyl include: spirocyclopropyl, spirocyclobutyl, spirocyclopentyl and spirocyclohexyl.
- treatment refers to both treatment and prevention.
- Ci-salkoxy examples include methoxy, ethoxy, n-propoxy, t-butoxy, and pentyloxy; examples of C ⁇ . 6 alkanoyl incude formyl, ethanoyl, propanoyl or pentanoyl, examples of arylCi. 6 alkyl include benzyl, phenethyl, 3-phenylpropyl, 2-phenylpropyl, 4-phenylbutyl, 2- ⁇ henylbutyl, 3-phenylbutyl, benzhydryl, 2,2-diphenylethyl and 3,3-diphenylbutyl.
- the invention includes in its definition any such optically active or racemic form which possesses the property of treating type II diabetes and/ or obesity.
- the synthesis of optically active forms may be carried out by standard techniques of organic chemistry well known in the art, for example by synthesis from optically active starting materials or by resolution of a racemic form. Similarly, activity of these compounds may be evaluated using the standard laboratory techniques referred to hereinafter.
- the invention also relates to any and all tautomeric forms of the compounds of the different features of the invention that possess the property of treating type II diabetes and/ or obesity.
- R 1 and R 3 are selected from either of the following: (a) R is phenyl or phenyl disubstituted in the 2,6-positions and R is phenyl or is phenyl disubstituted in the 2,6-positions; (b) each of R 1 and R 3 is phenyl disubstituted in the 2,6-position, (c) R is phenyl disubstituted in the 2,6-positions and R is phenyl trisubstituted in the 2,4,6-positions; (d) R 1 is 2,6-bis(l-methylethyl)phenyl and R 3 is 2,6-bis(l-methylethyl)phenyl or 2,4,6- tris( 1 -methylelthyl) ⁇ henyl, (e) one of R 1 and R 3 is the group
- R 6 and R 7 are independently selected from hydrogen and C 1-6 alkyl, or when R 6 is hydrogen, R 7 can be selected from the groups defined for R 8 ; and R 8 is phenyl optionally substituted with from 1 to 3 substituents selected C 1-6 alkyl C 1-6 alkoxy , phenoxy, hydroxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, carboxy, C 1- alkoxycarbonyl, and -(CH 2 )pNR 4 R 5 wherein p, R 4 and R 5 are as defined above, (ii) one of R 1 and R 3 is phenyl, and more preferably wherein one of R 1 and R 3 is substituted phenyl, and still more preferably wherein one of R and R is phenyl disubstituted in the 2,6-positions.
- R 1 and R 3 are phenyl disubstituted in the 2,6-positions.
- R 1 is phenyl disubstituted in the 2,6-position and R 3 is trisubstituted in the 2,4,6 - positions
- R 1 is 2,6-bis(l-methylethyl)phenyl
- R 3 is 2,6-bis(l-methylethyl)phenyl or 2,4,6-tris(l- methylethyl)phenyl.
- X is selected from oxygen, sulfur and (-CR a R b -) n ; Y is selected from oxygen, sulfur and (-CR a R -) n , with the proviso that at least one of X or Y is (-CR a R b -) n wherein n is an integer of from 1 to 4 and R a and R b are independently selected from hydrogen, C 1-6 alkyl, optionally substituted phenyl, halo, hydroxy, C 1-6 alkoxy, C 1-6 alkanoyloxy and C 3-12 cycloalkyl, or R a and R b taken together form a carbonyl or C 3-10 spirocycloalkyl; R 1 is selected from optionally substituted phenyl, Ci.ioalkyl and C 3-1 ocycloalkyl; R 2 is hydrogen; R 3 is selected from optionally substituted phenyl, Ci.ioalkyl, C 3-8 cycloalkyl, optional
- X is oxygen; Y is (-CR a R b -) n wherein n is an integer of from 1 to 2; R 1 is optionally substituted phenyl; R 2 is hydrogen; R 3 is selected from optionally substituted phenyl, optionally substituted phenoxy, C 1-10 alkyl and C 3-1 ocycloalkyl; and R a and R b are independently selected from hydrogen, C 1-6 alkyl, optionally substituted phenyl, halo, hydroxy, C 1-6 alkoxy, C 1-6 alkanoyloxy, C 3-12 cycloalkyl, or R a and R b taken together form a carbonyl or a C5 -12 spirocycloalkyl.
- X is oxygen
- Y is (-CR a R b -)n wherein n is an integer of from 1 to 4 and R' and R" are each independently hydrogen, alkyl, alkoxy, halogen, hydroxy, acyloxy, cycloalkyl, phenyl optionally substituted or R' and R" together form a spirocycloalkyl or a carbonyl;
- R and R are independently selected from (a) phenyl or phenoxy wherein the phenyl or phenoxy group is optionally substituted with 1 to 5 substituents independently selected from phenyl, C 1-6 alkyl, C 1-6 alkoxy, phenoxy, hydroxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, carboxy, C 1- alkoxycarbony and -(CF p N iRs wherein p is 0 or 1, and R and R s are independently selected from hydrogen or C 1- alkyl; (b) naphth-1-y
- Particularly preferred compounds for use in the method according to the present invention are wherein the compound is selected from: Sulfamic acid ( ⁇ henylacetyl)-2,6-bis(l-methylethyl)phenyl ester, Sulfamic acid [[2,4,6-tris(l-methylethyl)phenyl]acetyl-2,6-bis(l-methylethyl)phenyl ester, Sulfamic acid[[2,6-bis(l-methylethyl)phenyl]acetyl]-2,6-bis(l-methylethyl)phenyl ester, Sulfamic acid [[2,4,6-tris(l-methylethyl)phenyl]acetyl-2,4,6-tris(l-methylethyl)phenyl ester, Sulfamic acid [[2,6-bis(l-methylethyl)phenyl]acetyl]-2,4,6-tris(l-methyle
- the compounds of Formulas (I) or pharmaceutically acceptable salts, pro-drugs or solvates thereof are administered to the patient at dosage levels of from 20 to 700 mg per day. For a normal human adult of approximately 70 kg of body weight, this translates into a dosage of from 0.3 to 10 mg kg of body weight per day.
- the specific dosages employed, however, may be varied depending upon the requirements of the patient, the severity of the condition being treated, and the activity of the compound being employed. The determination of optimum dosages for a particular situation is within the skill of the art.
- the compounds of Formula (I) may be administered in the form of a pro-drug which is broken down in the human or animal body to give a compound of the Formula (I).
- pro-drugs include in-vivo hydrolysable esters of a compound of the Formula (I).
- Various forms of pro-drugs are known in the art.
- pro-drug derivatives see: a) Design of Prodrugs, edited by H. Bundgaard, (Elsevier, 1985) and Methods in Enzymology, Vol. 42, p. 309-396, edited by K. Widder, et al. (Academic Press, 1985); b) A Textbook of Drug Design and Development, edited by Krogsgaard-Larsen and H. Bundgaard, Chapter 5 "Design and Application of Prodrugs", by H. Bundgaard p. 113- 191 (1991); c) H.
- An in-vivo hydrolysable ester of a compound of the Formula (I) containing a carboxy or a hydroxy group is, for example, a pharmaceutically-acceptable ester which is hydrolysed in the human or animal body to produce the parent acid or alcohol.
- Suitable pharmaceutically-acceptable esters for carboxy include C 1-6 alkoxymethyl esters for example methoxymethyl, C 1-6 alkanoyloxymethyl esters for example pivaloyloxymethyl, phthalidyl esters, C ⁇ scycloalkoxycarbonyloxyCi. 6 alkyl esters for example
- An in-vivo hydrolysable ester of a compound of the Formula (I) containing a hydroxy group includes inorganic esters such as phosphate esters (including phosphoramidic cyclic esters) and -acyloxyalkyl ethers and related compounds which as a result of the in- vivo hydrolysis of the ester breakdown to give the parent hydroxy group/s.
- Examples of -acyloxyalkyl ethers include acetoxymethoxy and 2,2-dimethylpropionyloxy-methoxy.
- a selection of in-vivo hydrolysable ester forming groups for hydroxy include alkanoyl, benzoyl, phenylacetyl and substituted benzoyl and phenylacetyl, alkoxycarbonyl (to give alkyl carbonate esters), dialkylcarbamoyl and N-(dialkylaminoethyl)-N-alkylcarbamoyl (to give carbamates), dialkylaminoacetyl and carboxy acetyl.
- a suitable pharmaceutically-acceptable salt of a compound of the invention is, for example, an acid-addition salt of a compound of the invention which is sufficiently basic, for example, an acid-addition salt with, for example, an inorganic or organic acid, for example hydrochloric, hydrobromic, sulphuric, phosphoric, trifluoroacetic, citric or maleic acid.
- a suitable pharmaceutically-acceptable salt of a compound of the invention which is sufficiently acidic is an alkali metal salt, for example a sodium or potassium salt, an alkaline earth metal salt, for example a calcium or magnesium salt, an ammonium salt or a salt with an organic base which affords a physiologically-acceptable cation, for example a salt with methylamine, dimethylamine, trimethylamine, piperidine, morpholine or tris-(2-hydroxyethyl)amine.
- an alkali metal salt for example a sodium or potassium salt
- an alkaline earth metal salt for example a calcium or magnesium salt
- an ammonium salt or a salt with an organic base which affords a physiologically-acceptable cation
- a salt with methylamine, dimethylamine, trimethylamine, piperidine, morpholine or tris-(2-hydroxyethyl)amine for example a salt with methylamine, dimethylamine, trimethylamine, piperidine, morpholine or tris-(2-
- a compound of Formula (I) can be provided as part of a pharmaceutical formulation which also includes a pharmaceutically acceptable diluent or carrier (eg, water).
- a pharmaceutical formulation which also includes a pharmaceutically acceptable diluent or carrier (eg, water).
- the formulation may be in the form of tablets, capsules, granules, powders, syrups, emulsions (eg, lipid emulsions), suppositories, ointments, creams, drops, suspensions (eg, aqueous or oily suspensions) or solutions (eg, aqueous or oily solutions).
- the formulation may include one or more additional substances independently selected from stabilising agents, wetting agents, emulsifying agents, buffers, lactose, sialic acid, magnesium stearate, terra alba, sucrose, corn starch, talc, gelatin, agar, pectin, peanut oil, olive oil, cacao butter and ethylene glycol.
- stabilising agents wetting agents, emulsifying agents, buffers, lactose, sialic acid, magnesium stearate, terra alba, sucrose, corn starch, talc, gelatin, agar, pectin, peanut oil, olive oil, cacao butter and ethylene glycol.
- the patient may receive a daily dose of O.lmgkg "1 to 30mgkg _1 (preferably, 5mgkg _1 to 20mgkg "1 ) of the compound, the compound being administered 1 to 4 times per day.
- the intravenous, subcutaneous and intramuscular dose may be given by means of a bolus injection.
- the intravenous dose may be given by continuous infusion over a period of time.
- the patient may receive a daily oral dose which is approximately equivalent to the daily parenteral dose, the composition being administered 1 to 4 times per day.
- a suitable pharmaceutical formulation is one suitable for oral administration in unit dosage form, for example as a tablet or capsule, which contains between lOmg and lg (preferably, 100 mg and lg) of the compound of the invention.
- Buffers, pharmaceutically acceptable co-solvents eg, polyethylene glycol, propylene glycol, glycerol or EtOH
- complexing agents such as hydroxy-propyl ⁇ cyclodextrin
- the compounds described herein may be applied as a sole therapy or may involve, in addition to the subject of the present invention, one or more other substances and/or treatments. Such conjoint treatment may be achieved by way of the simultaneous, sequential or separate administration of the individual components of the treatment. Simultaneous treatment may be in a single tablet or in separate tablets.
- pharmacotherapy may include the following main categories of treatment: 1) Insulin and insulin analogues;
- Insulin secretagogues including sulphonylureas (for example glibenclamide, glipizide) and prandial glucose regulators (for example repaglinide, nateglinide);
- sulphonylureas for example glibenclamide, glipizide
- prandial glucose regulators for example repaglinide, nateglinide
- Insulin sensitising agents including PPARg agonists (for example pioglitazone and rosiglitazone); 4) Agents that suppress hepatic glucose output (for example metfor in).
- Anti-obesity agents for example sibutramine and orlistat
- Anti- dyslipidaemia agents such as, HMG-CoA reductase inhibitors (statins, eg pravastatin); PPAR agonists (fibrates, eg gemfibrozil); bile acid sequestrants (cholestyramine); cholesterol absorption inhibitors (plant stanols, synthetic inhibitors); bile acid absorption inhibitors (L ATi) and nicotinic acid and analogues (niacin and slow release formulations); 9) Antihypertensive agents such as, ⁇ blockers (eg atenolol, inderal); ACE inhibitors (eg lisinopril); Calcium antagonists (eg. nifedipine); Angiotensin receptor antagonists (eg candesartan), antagonists and diuretic agents (eg. furosemide, benzthiazide);
- Haemostasis modulators such as, antithrombotics, activators of fibrinolysis and antiplatelet agents; thrombin antagonists; factor Xa inhibitors; factor VLTa inhibitors); antiplatelet agents (eg. aspirin, clopidogrel); anticoagulants (heparin and Low molecular weight analogues, hirudin) and warfarin; and
- Anti-inflammatory agents such as non-steroidal anti-infammatory drugs (eg. aspirin) and steroidal anti-inflammatory agents (eg. cortisone).
- non-steroidal anti-infammatory drugs eg. aspirin
- steroidal anti-inflammatory agents eg. cortisone
- the ability of compounds to inhibit ACAT can be measured using an in-vitro test described in Field & Salone (1982) Biochemica et Biophysica, 712, 557-570.
- the test assesses the ability of a test compound to inhibit the acylation of cholesterol by oleic acid by measuring the amount of radiolabeled cholesterol oleate formed from radiolabeled oleic acid in a tissue preparation containing rat liver microsomes.
- DGAT The ability of compounds to inhibit DGAT can be measured as described in Coleman (1992) Methods in Enzymology 209, 98-102.
- sulfamic acid [[2,4,6-tris(l-methylethyl)phenyl]acetyl-2,6-bis(l- methylethyl)phenyl ester against DGAT1, DGAT2 and ACAT was measured in rat and human liver microsomes.
- DGAT1 and DGAT2 can be distinguished since DGAT2 is not active at high magnesium concentrations (concentrations of 50mM or higher) whilst DGAT1 retains its activity at high magnesium concentrations.
Abstract
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EP04791619A EP1682112A1 (en) | 2003-10-29 | 2004-10-28 | Use of sulfonamide compounds for the treatment of diabetes and/or obesity |
JP2006537427A JP2007509919A (en) | 2003-10-29 | 2004-10-28 | Use of sulfonamide compounds for the treatment of diabetes and / or obesity |
US10/577,357 US20070155832A1 (en) | 2003-10-29 | 2004-10-28 | Use of sulfonamide compounds for the treatment of diabetes and/or obesity |
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WO2007126957A2 (en) | 2006-03-31 | 2007-11-08 | Novartis Ag | New compounds |
WO2008017381A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
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JP2008540485A (en) * | 2005-05-10 | 2008-11-20 | エフ.ホフマン−ラ ロシュ アーゲー | Diacylglycerol acyltransferase inhibitor |
ES2359653T3 (en) * | 2006-06-08 | 2011-05-25 | Astrazeneca Ab | BENCIMIDAZOLES AND ITS USE FOR THE TREATMENT OF DIABETES. |
BRPI0815490A2 (en) * | 2007-08-17 | 2017-03-21 | Astrazeneca Ab | compound, pharmaceutical composition, method for treating diabetes mellitus and / or obesity in a warm-blooded animal, and process for preparing a compound |
EP2341924A4 (en) | 2008-10-02 | 2013-01-23 | David Gladstone Inst | Methods of treating hepatitis c virus infection |
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Also Published As
Publication number | Publication date |
---|---|
GB0325192D0 (en) | 2003-12-03 |
JP2007509919A (en) | 2007-04-19 |
US20070155832A1 (en) | 2007-07-05 |
EP1682112A1 (en) | 2006-07-26 |
CN1901893A (en) | 2007-01-24 |
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