WO2005014777A3 - Methods and compositions for increasing the efficacy of biologically-active ingredients - Google Patents

Methods and compositions for increasing the efficacy of biologically-active ingredients Download PDF

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Publication number
WO2005014777A3
WO2005014777A3 PCT/US2003/032667 US0332667W WO2005014777A3 WO 2005014777 A3 WO2005014777 A3 WO 2005014777A3 US 0332667 W US0332667 W US 0332667W WO 2005014777 A3 WO2005014777 A3 WO 2005014777A3
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WO
WIPO (PCT)
Prior art keywords
compositions
efficacy
increasing
active agents
active ingredients
Prior art date
Application number
PCT/US2003/032667
Other languages
French (fr)
Other versions
WO2005014777A2 (en
Inventor
J Brian Windsor
Stan J Roux
Alan M Lloyd
Collin E Thomas
Original Assignee
Univ Texas
J Brian Windsor
Stan J Roux
Alan M Lloyd
Collin E Thomas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, J Brian Windsor, Stan J Roux, Alan M Lloyd, Collin E Thomas filed Critical Univ Texas
Priority to CA002502148A priority Critical patent/CA2502148A1/en
Priority to AU2003304398A priority patent/AU2003304398A1/en
Priority to US10/531,744 priority patent/US20060276339A1/en
Priority to EP03816736A priority patent/EP1576150A4/en
Publication of WO2005014777A2 publication Critical patent/WO2005014777A2/en
Publication of WO2005014777A3 publication Critical patent/WO2005014777A3/en

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    • A—HUMAN NECESSITIES
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    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
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    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
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    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
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    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.
PCT/US2003/032667 2002-10-16 2003-10-16 Methods and compositions for increasing the efficacy of biologically-active ingredients WO2005014777A2 (en)

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US10/531,744 US20060276339A1 (en) 2002-10-16 2003-10-16 Methods and compositions for increasing the efficacy of biologically-active ingredients
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US11564968B2 (en) 2016-09-27 2023-01-31 Camurus Ab Formulations containing a somatostatin receptor agonist

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AU2003304398A1 (en) 2005-02-25
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CA2502148A1 (en) 2005-02-17
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