WO2005014479A3 - Process for preparing radiolabeled compounds - Google Patents

Process for preparing radiolabeled compounds Download PDF

Info

Publication number
WO2005014479A3
WO2005014479A3 PCT/EP2004/008830 EP2004008830W WO2005014479A3 WO 2005014479 A3 WO2005014479 A3 WO 2005014479A3 EP 2004008830 W EP2004008830 W EP 2004008830W WO 2005014479 A3 WO2005014479 A3 WO 2005014479A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiolabeled compounds
radiolabelled compounds
preparing radiolabeled
preparing
compounds
Prior art date
Application number
PCT/EP2004/008830
Other languages
French (fr)
Other versions
WO2005014479A2 (en
Inventor
Dirk Bender
Helene Audrain
Christophe Plisson
Original Assignee
Glaxo Group Ltd
Dirk Bender
Helene Audrain
Christophe Plisson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0318728A external-priority patent/GB0318728D0/en
Priority claimed from GB0416141A external-priority patent/GB0416141D0/en
Application filed by Glaxo Group Ltd, Dirk Bender, Helene Audrain, Christophe Plisson filed Critical Glaxo Group Ltd
Priority to CA002536659A priority Critical patent/CA2536659A1/en
Priority to US10/567,524 priority patent/US20070059230A1/en
Priority to EP04763865A priority patent/EP1663868A2/en
Priority to JP2006522964A priority patent/JP2007501764A/en
Publication of WO2005014479A2 publication Critical patent/WO2005014479A2/en
Publication of WO2005014479A3 publication Critical patent/WO2005014479A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B35/00—Boron; Compounds thereof
    • C01B35/08—Compounds containing boron and nitrogen, phosphorus, oxygen, sulfur, selenium or tellurium
    • C01B35/10—Compounds containing boron and oxygen
    • C01B35/1018—Carbonyl compounds derived from boron hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A novel process for preparing radiolabelled compounds by incorporation of radioactive carbonyl groups into precursors, which are then used to make the radiolabelled compounds. These radiolabelled compounds have a number of uses including in vivo imaging techniques such as positron emission tomography.
PCT/EP2004/008830 2003-08-08 2004-08-05 Process for preparing radiolabeled compounds WO2005014479A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002536659A CA2536659A1 (en) 2003-08-08 2004-08-05 Process
US10/567,524 US20070059230A1 (en) 2003-08-08 2004-08-05 Process
EP04763865A EP1663868A2 (en) 2003-08-08 2004-08-05 Process for preparing radiolabelled compounds
JP2006522964A JP2007501764A (en) 2003-08-08 2004-08-05 Method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0318728A GB0318728D0 (en) 2003-08-08 2003-08-08 Process
GB0318728.3 2003-08-08
GB0416141.0 2004-07-19
GB0416141A GB0416141D0 (en) 2004-07-19 2004-07-19 Novel process

Publications (2)

Publication Number Publication Date
WO2005014479A2 WO2005014479A2 (en) 2005-02-17
WO2005014479A3 true WO2005014479A3 (en) 2006-06-01

Family

ID=34137756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/008830 WO2005014479A2 (en) 2003-08-08 2004-08-05 Process for preparing radiolabeled compounds

Country Status (5)

Country Link
US (1) US20070059230A1 (en)
EP (1) EP1663868A2 (en)
JP (1) JP2007501764A (en)
CA (1) CA2536659A1 (en)
WO (1) WO2005014479A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2401216T3 (en) 2002-12-20 2013-04-17 Glaxo Group Limited New benzazepine derivatives
GB0408083D0 (en) * 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
US20060039521A1 (en) * 2004-06-22 2006-02-23 Schaefer Daniel R Direct production of thermal antineutrons and antiprotons
CA2594383A1 (en) 2005-01-07 2006-07-13 Glaxo Group Limited 6- (2 , 3 , 4 , 5-tetrahydro-lh-benzo [d] azepin-7-yloxy) -nicotamide derivatives as radiolabelled ligands
GB2441014A (en) * 2006-09-14 2008-02-20 Glaxo Group Ltd Polymorphic form of 6-(3-cyclobuty1-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methyl-nicotinamide hydrochloride for use in therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025243A1 (en) * 1999-10-05 2001-04-12 Mallinckrodt Inc. Carbon monoxide source for preparation of transition-metal-carbonyl-complexes
WO2002048072A2 (en) * 2000-12-14 2002-06-20 Personal Chemistry I Uppsala Ab Organic reactions with co generating materials
WO2002102711A1 (en) * 2001-06-19 2002-12-27 Amersham Plc Method and apparatus for production and use of [11c] carbon monoxide in labeling synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025243A1 (en) * 1999-10-05 2001-04-12 Mallinckrodt Inc. Carbon monoxide source for preparation of transition-metal-carbonyl-complexes
WO2002048072A2 (en) * 2000-12-14 2002-06-20 Personal Chemistry I Uppsala Ab Organic reactions with co generating materials
WO2002102711A1 (en) * 2001-06-19 2002-12-27 Amersham Plc Method and apparatus for production and use of [11c] carbon monoxide in labeling synthesis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALBERTO R ET AL: "SYNTHESIS AND PROPERTIES OF BORANOCARBONATE: A CONVENIENT IN SITU CO SOURCE FOR THE AQUEOUS PREPARATION OF [99MTC(OH2)3(CO)3]+", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, 13 March 2001 (2001-03-13), pages 3135 - 3136, XP001120003, ISSN: 0002-7863 *
AUDRAIN, HELENE ET AL: "Utilization of [11C]-labelled boron carbonyl complexes in palladium carbonylation reaction", CHEMICAL COMMUNICATIONS (CAMBRIDGE, UNITED KINGDOM) , (5), 558-559 CODEN: CHCOFS; ISSN: 1359-7345, 2004, XP002372602 *
JONES L H ET AL: "Potential constants of borane carbonyl", JOURNAL OF CHEMICAL PHYSICS USA, vol. 70, no. 2, 1979, pages 749 - 757, XP008041698, ISSN: 0021-9606 *
VENKATACHAR, A. C. ET AL: "Microwave spectrum , structure, quadrupole coupling constants and dipole moment of carbon monoxide- borane", JOURNAL OF MOLECULAR STRUCTURE, vol. 38, 1977, pages 17 - 23, XP002314162 *
ZEISLER S K ET AL: "Conversion of No-carrier-added [<11>C]carbon Dioxide to [<11>C]carbon Monoxide on Molybdenum for the Synthesis of <11>C-labelled Aromatic Ketones", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, vol. 48, no. 8, August 1997 (1997-08-01), pages 1091 - 1095, XP004094769, ISSN: 0969-8043 *

Also Published As

Publication number Publication date
CA2536659A1 (en) 2005-02-17
WO2005014479A2 (en) 2005-02-17
EP1663868A2 (en) 2006-06-07
US20070059230A1 (en) 2007-03-15
JP2007501764A (en) 2007-02-01

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