WO2005010482A3 - Detection of biomarkers - Google Patents

Detection of biomarkers Download PDF

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Publication number
WO2005010482A3
WO2005010482A3 PCT/US2004/017609 US2004017609W WO2005010482A3 WO 2005010482 A3 WO2005010482 A3 WO 2005010482A3 US 2004017609 W US2004017609 W US 2004017609W WO 2005010482 A3 WO2005010482 A3 WO 2005010482A3
Authority
WO
WIPO (PCT)
Prior art keywords
constituent
biochip
desorbed
breath
exhaled breath
Prior art date
Application number
PCT/US2004/017609
Other languages
French (fr)
Other versions
WO2005010482A9 (en
WO2005010482A2 (en
Inventor
Benjamin Reed
Nathan Harris
Original Assignee
Ciphergen Biosystems Inc
Benjamin Reed
Nathan Harris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0313058A priority Critical patent/GB0313058D0/en
Priority to GB0313058.0 priority
Application filed by Ciphergen Biosystems Inc, Benjamin Reed, Nathan Harris filed Critical Ciphergen Biosystems Inc
Publication of WO2005010482A2 publication Critical patent/WO2005010482A2/en
Publication of WO2005010482A3 publication Critical patent/WO2005010482A3/en
Publication of WO2005010482A9 publication Critical patent/WO2005010482A9/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/497Physical analysis of biological material of gaseous biological material, e.g. breath
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

The present invention provides a method for analyzing one or more constituent of exhaled breath. The method includes contacting a biochip with the exhaled breath such that the constituent interacts with the biochip and becomes reversibly immobilized thereon. The breath constituent is desorbed from the biochip in a mass spectrometer and the desorbed constituent is subjected to mass spectrometric analysis. The spectrum that results includes peak(s) that are representative of the constituent, allowing its characterization and, optionally, its quantification.
PCT/US2004/017609 2003-06-06 2004-06-04 Detection of biomarkers WO2005010482A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0313058A GB0313058D0 (en) 2003-06-06 2003-06-06 Detection of biomarkers
GB0313058.0 2003-06-06

Publications (3)

Publication Number Publication Date
WO2005010482A2 WO2005010482A2 (en) 2005-02-03
WO2005010482A3 true WO2005010482A3 (en) 2005-06-30
WO2005010482A9 WO2005010482A9 (en) 2005-09-15

Family

ID=9959474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/017609 WO2005010482A2 (en) 2003-06-06 2004-06-04 Detection of biomarkers

Country Status (2)

Country Link
GB (1) GB0313058D0 (en)
WO (1) WO2005010482A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138272A1 (en) * 2005-06-13 2006-12-28 Northwestern University Metal ion-based immobilization

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101105A (en) * 1990-11-02 1992-03-31 Univeristy Of Maryland, Baltimore County Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor
US6248078B1 (en) * 1998-08-31 2001-06-19 Johns Hopkins University Volatile biomarkers for analysis of hepatic disorders
US20030004426A1 (en) * 2001-05-24 2003-01-02 Melker Richard J. Method and apparatus for detecting environmental smoke exposure
US20030060726A1 (en) * 2001-05-23 2003-03-27 Yuh-Jiuan Lin Breath-based diagnostic device including a array of multiple sensors
US6557416B2 (en) * 2000-03-31 2003-05-06 Ant Technology Co., Ltd. High resolution biosensor system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101105A (en) * 1990-11-02 1992-03-31 Univeristy Of Maryland, Baltimore County Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor
US6248078B1 (en) * 1998-08-31 2001-06-19 Johns Hopkins University Volatile biomarkers for analysis of hepatic disorders
US6557416B2 (en) * 2000-03-31 2003-05-06 Ant Technology Co., Ltd. High resolution biosensor system
US20030060726A1 (en) * 2001-05-23 2003-03-27 Yuh-Jiuan Lin Breath-based diagnostic device including a array of multiple sensors
US20030004426A1 (en) * 2001-05-24 2003-01-02 Melker Richard J. Method and apparatus for detecting environmental smoke exposure

Also Published As

Publication number Publication date
WO2005010482A9 (en) 2005-09-15
GB0313058D0 (en) 2003-07-09
WO2005010482A2 (en) 2005-02-03

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