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WO2005000235A3 - NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME - Google Patents

NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME

Info

Publication number
WO2005000235A3
WO2005000235A3 PCT/US2004/018962 US2004018962W WO2005000235A3 WO 2005000235 A3 WO2005000235 A3 WO 2005000235A3 US 2004018962 W US2004018962 W US 2004018962W WO 2005000235 A3 WO2005000235 A3 WO 2005000235A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
proteins
fusion
disclosed
acid
il
Prior art date
Application number
PCT/US2004/018962
Other languages
French (fr)
Other versions
WO2005000235A2 (en )
Inventor
David B Weiner
Michele Kutzler
Andrew K Choo
Joo-Sung Yang
Jean D Boyer
Original Assignee
Univ Pennsylvania
David B Weiner
Michele Kutzler
Andrew K Choo
Joo-Sung Yang
Jean D Boyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.
PCT/US2004/018962 2003-06-13 2004-06-14 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME WO2005000235A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US47820503 true 2003-06-13 2003-06-13
US47821003 true 2003-06-13 2003-06-13
US60/478,210 2003-06-13
US60/478,205 2003-06-13

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR20057023994A KR101269548B1 (en) 2003-06-13 2004-06-14 Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
KR20117023822A KR101225473B1 (en) 2003-06-13 2004-06-14 Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
EP20040776577 EP1638987B1 (en) 2003-06-13 2004-06-14 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME
JP2006533791A JP2007516696A (en) 2003-06-13 2004-06-14 Compositions and methods of use thereof comprising a nucleic acid sequence and their encoding IgE signal peptide and / or IL-15
CA 2529145 CA2529145C (en) 2003-06-13 2004-06-14 Nucleic acid sequences encoding and compositions comprising ige signal peptide and/or il-15 and methods for using the same
CN 200480022891 CN1832956B (en) 2003-06-13 2004-06-14 Nucleic acid sequences encoding and compositions comprising ige signal peptide and/or il-15 and methods for using the same
US10560650 US8173786B2 (en) 2003-06-13 2004-06-14 Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US13466015 US20120276142A1 (en) 2003-06-13 2012-05-07 Nucleic acid sequences encoding and compositions comprising ige signal peptide and/or il-15 and methods for using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13466015 Division US20120276142A1 (en) 2003-06-13 2012-05-07 Nucleic acid sequences encoding and compositions comprising ige signal peptide and/or il-15 and methods for using the same

Publications (2)

Publication Number Publication Date
WO2005000235A2 true WO2005000235A2 (en) 2005-01-06
WO2005000235A3 true true WO2005000235A3 (en) 2005-06-16

Family

ID=33555491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/018962 WO2005000235A3 (en) 2003-06-13 2004-06-14 NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME

Country Status (7)

Country Link
US (2) US8173786B2 (en)
EP (2) EP2292634A3 (en)
JP (2) JP2007516696A (en)
KR (2) KR101225473B1 (en)
CN (1) CN1832956B (en)
CA (1) CA2529145C (en)
WO (1) WO2005000235A3 (en)

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US8173786B2 (en) * 2003-06-13 2012-05-08 The Trustees Of The University Of Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
KR101421745B1 (en) * 2006-01-13 2014-07-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Vaccines and immunotherapeutics using codon optimized il-15 and methods for using the same
KR20170024131A (en) * 2006-07-28 2017-03-06 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Improved vaccines and methods for using the same
JP5788676B2 (en) * 2008-01-11 2015-10-07 イノビオ ファーマシューティカルズ,インコーポレイティド A new vaccine against multiple subtypes of dengue virus
CA2720168A1 (en) * 2008-04-04 2009-10-08 David B. Weiner Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
JP5744719B2 (en) * 2008-04-04 2015-07-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Consensus sequence of Chikungunya virus protein, nucleic acid molecule encoding the same, and compositions employing this and methods
CA2771334A1 (en) 2009-09-14 2011-03-17 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
CN102781952B (en) * 2010-02-08 2015-09-02 宾夕法尼亚大学托管会 A nucleic acid molecule encoding rantes comprising compositions thereof and methods of use thereof
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
KR20140048853A (en) 2011-02-11 2014-04-24 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same
KR20140116095A (en) 2011-12-12 2014-10-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Proteins comprising mrsa pbp2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat mrsa infections
CN104619719A (en) * 2012-04-10 2015-05-13 宾夕法尼亚大学理事会 Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
EP2836230A4 (en) * 2012-04-12 2016-03-02 Univ Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same

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Also Published As

Publication number Publication date Type
US8173786B2 (en) 2012-05-08 grant
JP2012110345A (en) 2012-06-14 application
EP1638987A2 (en) 2006-03-29 application
EP1638987B1 (en) 2014-11-19 grant
WO2005000235A2 (en) 2005-01-06 application
KR101269548B1 (en) 2013-06-21 grant
US20120276142A1 (en) 2012-11-01 application
CN1832956B (en) 2013-11-20 grant
EP2292634A2 (en) 2011-03-09 application
KR101225473B1 (en) 2013-01-24 grant
EP1638987A4 (en) 2007-12-26 application
US20070041941A1 (en) 2007-02-22 application
CN1832956A (en) 2006-09-13 application
KR20060030041A (en) 2006-04-07 application
JP2007516696A (en) 2007-06-28 application
JP5623444B2 (en) 2014-11-12 grant
EP2292634A3 (en) 2012-08-08 application
KR20110129945A (en) 2011-12-02 application
CA2529145C (en) 2017-07-11 grant
CA2529145A1 (en) 2005-01-06 application

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