WO2004112768A1 - Memantine oral dosage forms - Google Patents

Memantine oral dosage forms Download PDF

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Publication number
WO2004112768A1
WO2004112768A1 PCT/US2004/018506 US2004018506W WO2004112768A1 WO 2004112768 A1 WO2004112768 A1 WO 2004112768A1 US 2004018506 W US2004018506 W US 2004018506W WO 2004112768 A1 WO2004112768 A1 WO 2004112768A1
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WO
WIPO (PCT)
Prior art keywords
memantine
dosage form
patient
dose
oral dosage
Prior art date
Application number
PCT/US2004/018506
Other languages
French (fr)
Inventor
Bruce A. Firestone
John J. Vander Zanden
Janet K. Cheetham
Richard Kurjan
Teresa H. Kuan
Chin-Ming Chang
J. Abraham M. Espiritu
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Priority to BRPI0411451-5A priority Critical patent/BRPI0411451A/en
Priority to CA002529535A priority patent/CA2529535A1/en
Priority to EP04754939A priority patent/EP1631273A1/en
Priority to MXPA05012810A priority patent/MXPA05012810A/en
Priority to JP2006517215A priority patent/JP2006527774A/en
Priority to AU2004249151A priority patent/AU2004249151A1/en
Publication of WO2004112768A1 publication Critical patent/WO2004112768A1/en
Priority to IL172233A priority patent/IL172233A0/en
Priority to NO20055880A priority patent/NO20055880L/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Definitions

  • This invention relates to the pharmaceutical dosage forms. More specifically, this invention relates to oral dosage forms of memantine.
  • Mentamine is a drug that is believed to be useful to prevent nerve cell loss in glaucoma patients. It is also useful in the treatment of Alzheimer's Dementia. To avoid adverse effects associated with the drug, memantine is initially administered to the patient at a dose of 5 mg per day, which is gradually increased to a maintenance dose of either 10 mg or 20 mg per day. The dosage is increased by 5 mg biweekly until the maintenance dose is reached.
  • dosage forms of memantine that contain doses of memantine that are not 10 mg or 20 mg are useful in helping to overcome the difficulties described above. These dosage forms contain between 1 mg and 100 mg of memantine. Unlike other dosage forms of memantine containing a dose that is not 10 mg or 20 mg, these dosage forms are not prepared by the patient or the person administering the medication to the patient who divides a larger dose. In other words, the patient or the person administering the medication does not have to divide the dosage form to obtain the appropriate dose.
  • this invention provides for 5 mg and 15 mg tablets of memantine that are available to the patient or the person administering the drug to the patient in those forms, meaning that the patient does not have to divide a 10 mg tablet to obtain a 5 mg dose or take 1 Vz 10 mg tablets to obtain a 15 mg dose.
  • Another significant contribution this invention makes to the art is that it allows a maintenance dose to be administered that is not 10 or 20 mg. For example, if a person needs more than 10 mg daily of memantine, but a 20 mg daily dose is undesirable, the person could receive a 15 mg maintenance dose without having difficulties with misdosing.
  • Figure 1 shows the manufacturing process diagram for the 175 Kg process for Memantine HC1 tablets.
  • Figure 2 shows the manufacturing process flow chart for the 175 Kg process for Memantine HC1 tablets.
  • One aspect of this invention relates to an oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine.
  • said oral dosage form contains 5 mg,15 mg or 20 mg of memantine, where the particular dose of memantine used in relation to this invention is determined by the required dose of the patient according to the dosage schedule described above.
  • the oral dosage form is a solid dosage form, preferably a tablet.
  • Another embodiment of this invention relates to a method of administering memantine to a patient in amount that is not 10 mg, comprising administering to the patient an oral dosage form of memantine, wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine.
  • Another aspect of this invention relates to a packaged pharmaceutical product comprising individual oral dosage forms of memantine which contain 5 mg,15 mg, or 20 mg of memantine.
  • the packaged pharmaceutical product comprises individual oral dosage forms containing 5 mg of memantine, 10 mg of memantine, 15 mg of memantine, and 20 mg of memantine.
  • the packaged pharmaceutical product comprises individual oral dosage forms containing 5 mg of memantine and 10 mg of memantine.
  • the initial administration of 5 mg of memantine, or the increase in the dosage by 5 mg increments may be more than can be tolerated by the patient.
  • Another aspect of this invention relates to a method of treating a patient with memantine, comprising a. administering a gradually increasing dose of memantine to said patient until the maintenance dose is reached, and b. continuing to administer said maintenance dose on a regular basis as long as memantine is needed, wherein the maintenance dose is reached in a sufficiently long period of time to significantly reduce adverse events, wherein the increment in which the dose of memantine is increased in successive dosages is less than 5 mg of memantine.
  • adverse event refers to any undesirable side effect or toxic effect associated with memantine.
  • it is preferable that the dose of memantine is increase by an increment of about 0.25 to about 0.5 mg each day until the maintenance dose is reached.
  • the milled memantine HCl microcrystalline cellulose mixture is combined with the Lactose, microcrystalline cellulose (Avicel PH302, FMC Corporation, Philadelphia, PA), Crosscarmeilose sodium (FMC Biopolymer, Philadelphia, PA), and colloidal silicon dioxide (Cab-O-Sil, Cabot Corporation, Tuscola, IL).
  • the mixture is mixed for 95 revolutions and then passed through the 0.039-inch (1- mm) screen using the Quadro Comil with round impeller.
  • the mixture is placed back into the V-blender and mixed for 228 revolutions.
  • the Magnesium Stearate is manually passed through a 30-mesh (0.6-mm) screen and added into the V-blender.
  • blend samples are taken at 10 different locations (See Figure 5.2.1) using stainless steel side sample thief with 0.5-cc insert.
  • the blend samples are tested for blend uniformity prior to the compression of tablets.
  • the blend is charged into polyethylene lined drums.
  • the tablet press equipment is set up with appropriate punch tooling to produce each of the four dose strengths.
  • the upper punches are embossed with the appropriate logo, and the lower punches are bisected (tablet scoring).
  • the Memantine HC1 blend is manually scooped from the polyethylene lined drum into the press hopper.
  • the press is then set to the appropriate compression parameters to produce the required in-process tablet specifications.
  • the blend is compressed at the appropriate compression rate to produce the required tablets lot size per dose strength.
  • the tablet weight and hardness are monitored periodically as the tablets are collected in a polyethylene-lined drum.
  • tablet samples are collected at minimum frequency of beginning, middle and end of the compression run. These samples are tested for content uniformity prior to the film-coating step.
  • the coating procedure is carried out with the ingredients shown in the amounts listed in Table 2.
  • the coating equipment is set up with a 36-inch pan and three spray guns.
  • the first coating suspension is prepared with Colorcon's (West Point, PA) Opadry Purple 03B 10434 at 12% (w/w). This material contains titanium dioxide, FD&C Blue #2 and Red #40 (purple colorant), hydroxypropyl methylcellulose (HPMC; polymer carrier) and polyethylene glycol (PEG) 400 (plasticizer).
  • the second suspension is prepared with Opadry Clear YS-1-19025-A material at 5% (w/w). This clear coating material contains HPMC and PEG.
  • the coating equipment is set up with the appropriate parameters detailed in the coating batch records.
  • the purple coating solution is applied onto the tablets at the appropriate spray rate until the required amount is achieved.
  • the film-coat is applied at 4% of core weight for 5 mg dose and at 3% for the 10-20 mg dose tablets.
  • a final coat with the clear coating solution at 0.5% of each core weight is applied.
  • the tablets are allowed to dry in the coating pan for a short period prior to transfer into a polyethylene- lined drum.
  • a tablet comprising 5 mg of memantine, prepared according to example 1, daily for two weeks. No misdosing occurs. After two weeks, a tablet comprising 10 mg of memantine is administered daily for as long as the drug is needed.
  • a tablet comprising 10 mg of memantine is administered daily for two weeks.
  • a tablet comprising 15 mg of memantine, prepared according to Example 1 is administered daily for two weeks. No misdosing occurs.
  • a tablet comprising 20 mg of memantine is administered daily for as long as the drug is needed.
  • a tablet comprising 2 mg of memantine is administered for one week.
  • the patient receives a tablet comprising a 4 mg dose for one week.
  • the dose is increased by 2 mg each week until a 10 mg dose is reached at the beginning of the fifth week.
  • the tablet comprising 10 mg of memantine is administered daily for as long as the drug is needed.
  • a tablet comprising 2 mg of memantine is administered for one week.
  • the patient receives a tablet comprising a 4 mg dose for one week.
  • the dose is increased by 2 mg each week until a 20 mg dose is reached at the beginning of the tenth week.
  • the tablet comprising 20 mg of memantine is administered daily for as long as the drug is needed.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

This invention relates to an oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine or 20 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a lager dose of memantine. Other aspects of this invention relate to pharmaceutical products comprising said dosage forms and methods of administering memantine and treating disease with said dosage form.

Description

MEMANTINE ORAL DOSAGE FORMS
Field of the Invention This invention relates to the pharmaceutical dosage forms. More specifically, this invention relates to oral dosage forms of memantine.
Description of the Related Art
Mentamine is a drug that is believed to be useful to prevent nerve cell loss in glaucoma patients. It is also useful in the treatment of Alzheimer's Dementia. To avoid adverse effects associated with the drug, memantine is initially administered to the patient at a dose of 5 mg per day, which is gradually increased to a maintenance dose of either 10 mg or 20 mg per day. The dosage is increased by 5 mg biweekly until the maintenance dose is reached.
Currently two memantine products are marketed in Europe for the treatment of Alzheimer's Dementia. Both products, Axura® (Merz) and Ebixa® (Lundbeck) are marketed in packages of 10 mg tablets. The currently available products require the patient to track the dose that they are required to take according to how long they have been taking the drug, and to take Vz tablet, 1 tablet, l z tablets, or 2 tablets accordingly. Because the typical patient requiring this medication is using it to slow the progression of blindness or dementia, patients taking memantine are particularly susceptible to incorrect dosing with this type of graduated dose schedule. In particular, it is likely that the 5 mg and 15 mg doses will be especially problematic for patients because they are required to both choose the correct tablets and divide the 10 mg tablet in half. Furthermore, the patients must keep track of the half tablet left over after dividing the tablet for use in the next day. Finally, dividing a tablet introduces the possibility that the dose will not be consistent. SUMMARY OF THE INVENTION
Brief Description of the Invention
We have found that dosage forms of memantine that contain doses of memantine that are not 10 mg or 20 mg are useful in helping to overcome the difficulties described above. These dosage forms contain between 1 mg and 100 mg of memantine. Unlike other dosage forms of memantine containing a dose that is not 10 mg or 20 mg, these dosage forms are not prepared by the patient or the person administering the medication to the patient who divides a larger dose. In other words, the patient or the person administering the medication does not have to divide the dosage form to obtain the appropriate dose. While not intending to be limiting in any way, this invention for example, provides for 5 mg and 15 mg tablets of memantine that are available to the patient or the person administering the drug to the patient in those forms, meaning that the patient does not have to divide a 10 mg tablet to obtain a 5 mg dose or take 1 Vz 10 mg tablets to obtain a 15 mg dose. Another significant contribution this invention makes to the art is that it allows a maintenance dose to be administered that is not 10 or 20 mg. For example, if a person needs more than 10 mg daily of memantine, but a 20 mg daily dose is undesirable, the person could receive a 15 mg maintenance dose without having difficulties with misdosing.
Brief Description of the Drawing Figures
Figure 1 shows the manufacturing process diagram for the 175 Kg process for Memantine HC1 tablets.
Figure 2 shows the manufacturing process flow chart for the 175 Kg process for Memantine HC1 tablets.
Detailed Description of the Invention
One aspect of this invention relates to an oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine. Preferably, said oral dosage form contains 5 mg,15 mg or 20 mg of memantine, where the particular dose of memantine used in relation to this invention is determined by the required dose of the patient according to the dosage schedule described above.
In another aspect of this invention the oral dosage form is a solid dosage form, preferably a tablet.
Another embodiment of this invention relates to a method of administering memantine to a patient in amount that is not 10 mg, comprising administering to the patient an oral dosage form of memantine, wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine.
Another aspect of this invention relates to a packaged pharmaceutical product comprising individual oral dosage forms of memantine which contain 5 mg,15 mg, or 20 mg of memantine.
Preferably the packaged pharmaceutical product comprises individual oral dosage forms containing 5 mg of memantine, 10 mg of memantine, 15 mg of memantine, and 20 mg of memantine. In another preferred embodiment of this invention the packaged pharmaceutical product comprises individual oral dosage forms containing 5 mg of memantine and 10 mg of memantine.
In certain cases, the initial administration of 5 mg of memantine, or the increase in the dosage by 5 mg increments, may be more than can be tolerated by the patient. Another aspect of this invention relates to a method of treating a patient with memantine, comprising a. administering a gradually increasing dose of memantine to said patient until the maintenance dose is reached, and b. continuing to administer said maintenance dose on a regular basis as long as memantine is needed, wherein the maintenance dose is reached in a sufficiently long period of time to significantly reduce adverse events, wherein the increment in which the dose of memantine is increased in successive dosages is less than 5 mg of memantine. The term adverse event refers to any undesirable side effect or toxic effect associated with memantine. In relation to embodiments of this type, it is preferable that the dose of memantine is increase by an increment of about 0.25 to about 0.5 mg each day until the maintenance dose is reached.
The best mode of making and using the present invention are described in the following examples. These examples are given only to provide direction and guidance in how to make and use the invention, and are not intended to limit the scope of the invention in any way.
Example 1
Unless otherwise indicated, all steps in this procedure are carried out at room temperature. Table 1, below, shows the amounts of each ingredient used in this procedure. In a 2 cubic foot PK V-Blender, memantine HC1 (Conti BPC N.V., Landen, Belgium) and microcrystalline Cellulose
(Avicel PH101, FMC Corporation, Philadelphia, PA) are combined and mixed for 105 revolutions. The mixture is then milled with a Quadro Comil using a 0.024-inch (0.6-mm) screen and a square impeller. The milling step is repeated for a second time. The milled mixture is then filled into polyethylene lined drum.
In a 10 cubic foot PK V-blender, the milled memantine HCl microcrystalline cellulose mixture is combined with the Lactose, microcrystalline cellulose (Avicel PH302, FMC Corporation, Philadelphia, PA), Crosscarmeilose sodium (FMC Biopolymer, Philadelphia, PA), and colloidal silicon dioxide (Cab-O-Sil, Cabot Corporation, Tuscola, IL). The mixture is mixed for 95 revolutions and then passed through the 0.039-inch (1- mm) screen using the Quadro Comil with round impeller. The mixture is placed back into the V-blender and mixed for 228 revolutions. The Magnesium Stearate is manually passed through a 30-mesh (0.6-mm) screen and added into the V-blender. The mixture is mixed for final 57 revolutions. For the validation batches, blend samples are taken at 10 different locations (See Figure 5.2.1) using stainless steel side sample thief with 0.5-cc insert. The blend samples are tested for blend uniformity prior to the compression of tablets. The blend is charged into polyethylene lined drums.
The tablet press equipment is set up with appropriate punch tooling to produce each of the four dose strengths. The upper punches are embossed with the appropriate logo, and the lower punches are bisected (tablet scoring).
The Memantine HC1 blend is manually scooped from the polyethylene lined drum into the press hopper. The press is then set to the appropriate compression parameters to produce the required in-process tablet specifications. The blend is compressed at the appropriate compression rate to produce the required tablets lot size per dose strength. During the compression, the tablet weight and hardness are monitored periodically as the tablets are collected in a polyethylene-lined drum. For the validation batches, tablet samples are collected at minimum frequency of beginning, middle and end of the compression run. These samples are tested for content uniformity prior to the film-coating step.
The coating procedure is carried out with the ingredients shown in the amounts listed in Table 2. The coating equipment is set up with a 36-inch pan and three spray guns. The first coating suspension is prepared with Colorcon's (West Point, PA) Opadry Purple 03B 10434 at 12% (w/w). This material contains titanium dioxide, FD&C Blue #2 and Red #40 (purple colorant), hydroxypropyl methylcellulose (HPMC; polymer carrier) and polyethylene glycol (PEG) 400 (plasticizer). The second suspension is prepared with Opadry Clear YS-1-19025-A material at 5% (w/w). This clear coating material contains HPMC and PEG.
After the coating pan is charged with 50 kg of appropriate tablet dose strength, the coating equipment is set up with the appropriate parameters detailed in the coating batch records. The purple coating solution is applied onto the tablets at the appropriate spray rate until the required amount is achieved. The film-coat is applied at 4% of core weight for 5 mg dose and at 3% for the 10-20 mg dose tablets. Using the same coating parameters, a final coat with the clear coating solution at 0.5% of each core weight is applied. The tablets are allowed to dry in the coating pan for a short period prior to transfer into a polyethylene- lined drum.
Table 1 Ingredient Quantities for 175 Kg Lots of Memantine HC1 Blend
Figure imgf000008_0001
Table 2 Ingredient Quantities for Film Coating of 50 Kg of Memantine HC1 Tablets
Figure imgf000008_0002
Example 2
To a patient suffering from glaucoma, is administered a tablet comprising 5 mg of memantine, prepared according to example 1, daily for two weeks. No misdosing occurs. After two weeks, a tablet comprising 10 mg of memantine is administered daily for as long as the drug is needed.
Example 3
To a patient suffering from glaucoma, is administered a tablet comprising 5 mg of memantine, prepared according to example 1, daily for two weeks. No misdosing occurs. After two weeks, a tablet comprising 10 mg of memantine is administered daily for two weeks. At the beginning of the fourth week of the treatment, a tablet comprising 15 mg of memantine, prepared according to Example 1 , is administered daily for two weeks. No misdosing occurs. At the beginning of the sixth week of treatment, a tablet comprising 20 mg of memantine is administered daily for as long as the drug is needed.
Example 4
To a patient suffering from glaucoma, is administered a tablet comprising 2 mg of memantine is administered for one week. The patient then receives a tablet comprising a 4 mg dose for one week. The dose is increased by 2 mg each week until a 10 mg dose is reached at the beginning of the fifth week. During the first four weeks of administration of the drug, improved tolerance of the drug is observed. The tablet comprising 10 mg of memantine is administered daily for as long as the drug is needed.
Example 5
To a patient suffering from glaucoma, is administered a tablet comprising 2 mg of memantine is administered for one week. The patient then receives a tablet comprising a 4 mg dose for one week. The dose is increased by 2 mg each week until a 20 mg dose is reached at the beginning of the tenth week. During the first nine weeks of administration of the drug, improved tolerance of the drug is observed. The tablet comprising 20 mg of memantine is administered daily for as long as the drug is needed. Example 6
To a patient suffering from glaucoma, is administered a tablet comprising 5 mg of memantine, prepared according to example 1, daily for two weeks. No misdosing occurs. After two weeks, a tablet comprising 10 mg of memantine is administered daily for two weeks. At the beginning of the fourth week of the treatment, a tablet comprising 15 mg of memantine, prepared according to Example 1, is administered daily for as long as the drug is needed. No misdosing occurs.

Claims

What is claimed is:
I . An oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine.
2 The oral dosage form of claim 1 which contains 5 mg or 15 mg of memantine. 3 The oral dosage form of claim 2 which is a solid dosage form. 4 The oral dosage form of claim 3 which is a tablet. 5 The oral dosage form of claim 3 which contains 5 mg of memantine. 6 The oral dosage form of claim 3 which contains 15 mg of memantine. 7 The oral dosage form of claim 3 which contains 20 mg of memantine. 8 A method of administering memantine to a patient in amount that is not about 10 mg, comprising administering to the patient an oral dosage form of memantine, wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine. 9. The method of claim 8 wherein said dosage form contains 5 mg or 15 mg of memantine. 10. The method of claim 9 wherein said dosage form is a solid dosage form,
I I . The method of claim 10 wherein said dosage form is a tablet.
12. The method of claim 10 wherein said tablet contains 5 mg of memantine.
13. The method of claim 10 wherein said tablet contains 15 mg of memantine.
14. A packaged pharmaceutical product comprising individual oral dosage forms of memantine which contain 5 mg, 15 mg, or 20 mg of memantine.
15. The packaged pharmaceutical product of claim 14 which comprises individual oral dosage forms containing 5 mg of memantine, 10 mg of memantine, 15 mg of memantine, and 20 mg of memantine.
16. The packaged pharmaceutical product of claim 14 which comprises individual oral dosage forms containing 5 mg of memantine and 10 mg of memantine.
17. A method of treating a patient with memantine, comprising a. administering a gradually increasing dose of memantine to said patient until the maintenance dose is reached, and b. continuing to administer said maintenance dose on a regular basis as long as memantine is needed, wherein the maintenance dose is reached in a sufficiently long period of time to significantly reduce adverse events, wherein the increment in which the dose of memantine is increased in successive dosages is less than 5 mg of memantine. 18. The method of claim 17 wherein the dose of memantine is increased by an increment of about 0.25 to about 0.5 mg each day until the maintenance dose is reached.
PCT/US2004/018506 2003-06-16 2004-06-10 Memantine oral dosage forms WO2004112768A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0411451-5A BRPI0411451A (en) 2003-06-16 2004-06-10 oral dosage forms of memantine
CA002529535A CA2529535A1 (en) 2003-06-16 2004-06-10 Memantine oral dosage forms
EP04754939A EP1631273A1 (en) 2003-06-16 2004-06-10 Memantine oral dosage forms
MXPA05012810A MXPA05012810A (en) 2003-06-16 2004-06-10 Memantine oral dosage forms.
JP2006517215A JP2006527774A (en) 2003-06-16 2004-06-10 Memantine oral formulation
AU2004249151A AU2004249151A1 (en) 2003-06-16 2004-06-10 Memantine oral dosage forms
IL172233A IL172233A0 (en) 2003-06-16 2005-11-28 Memantine oral dosage forms
NO20055880A NO20055880L (en) 2003-06-16 2005-12-12 Memantine oral dosage forms

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US47897903P 2003-06-16 2003-06-16
US60/478,979 2003-06-16

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JP (1) JP2006527774A (en)
KR (1) KR20060033727A (en)
CN (1) CN1805737A (en)
AU (1) AU2004249151A1 (en)
BR (1) BRPI0411451A (en)
CA (1) CA2529535A1 (en)
IL (1) IL172233A0 (en)
MX (1) MXPA05012810A (en)
NO (1) NO20055880L (en)
PL (1) PL378902A1 (en)
RU (1) RU2006101225A (en)
TW (1) TW200524639A (en)
WO (1) WO2004112768A1 (en)
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WO2006058059A3 (en) * 2004-11-23 2006-07-06 Neuromolecular Pharmaceuticals Composition comprising a sustained release coating or matrix and an nmda receptor antagonist, method for administration such nmda antagonist to a subject
WO2006096194A3 (en) * 2004-06-17 2007-11-22 Merz Pharma Gmbh & Co Kgaa Drinkable immediate release tablet made with direct compression of memantine or neramexane
EP1908748A1 (en) * 2006-10-05 2008-04-09 Krka Process for the preparation of memantine and its hydrochloric acid salt form
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
US8058291B2 (en) 2005-04-06 2011-11-15 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of CNS-related conditions
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US9827200B2 (en) 2012-04-24 2017-11-28 Daiichi Sankyo Company, Limited Orally disintegrating tablet and production process therefor
KR20190076711A (en) 2017-12-22 2019-07-02 한미약품 주식회사 A hard capsule formulation comprising memantine with immediate and sustained release properties and a process for the preparation thereof

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US7086532B2 (en) * 2003-07-16 2006-08-08 Allergan, Inc. Titration/compliance pack with increasing doses
FR2855344A1 (en) * 2003-05-22 2004-11-26 France Telecom Context management system for use in network e.g. LAN, has computer server including transformation module to send application to master terminal permitting user to recover most appropriate context on master terminal
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
US20060159753A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Matrix type sustained-release preparation containing basic drug or salt thereof
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
US20090023778A1 (en) * 2005-04-28 2009-01-22 Eisai R&D Management Co., Ltd. Composition Containing Anti-Dementia Drug
PL1994012T3 (en) * 2006-02-10 2010-05-31 Janssen Pharmaceutica Nv Novel tricyclic dihydropyrazines as potassium channel openers
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