WO2004108694A1 - N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides - Google Patents
N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides Download PDFInfo
- Publication number
- WO2004108694A1 WO2004108694A1 PCT/GB2004/002308 GB2004002308W WO2004108694A1 WO 2004108694 A1 WO2004108694 A1 WO 2004108694A1 GB 2004002308 W GB2004002308 W GB 2004002308W WO 2004108694 A1 WO2004108694 A1 WO 2004108694A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- halo
- alkoxy
- compounds
- compound
- Prior art date
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- 239000000417 fungicide Substances 0.000 title abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 417
- -1 Z is CR Inorganic materials 0.000 claims description 387
- 125000005843 halogen group Chemical group 0.000 claims description 161
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 89
- 239000000203 mixture Substances 0.000 claims description 85
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 229910052739 hydrogen Inorganic materials 0.000 claims description 70
- 239000001257 hydrogen Substances 0.000 claims description 68
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 67
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 59
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 54
- 125000001424 substituent group Chemical group 0.000 claims description 49
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 125000004414 alkyl thio group Chemical group 0.000 claims description 40
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 39
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 35
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 31
- 229910052760 oxygen Inorganic materials 0.000 claims description 28
- 229910052717 sulfur Inorganic materials 0.000 claims description 25
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 23
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 230000000855 fungicidal effect Effects 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 20
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
- 241000233866 Fungi Species 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 17
- 238000005304 joining Methods 0.000 claims description 16
- 125000003282 alkyl amino group Chemical group 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 12
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 12
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 claims description 12
- 125000000304 alkynyl group Chemical group 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
- 125000006606 n-butoxy group Chemical group 0.000 claims description 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 125000001544 thienyl group Chemical group 0.000 claims description 10
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- 229910052727 yttrium Inorganic materials 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 239000002689 soil Substances 0.000 claims description 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- JQCSUVJDBHJKNG-UHFFFAOYSA-N 1-methoxy-ethyl Chemical group C[CH]OC JQCSUVJDBHJKNG-UHFFFAOYSA-N 0.000 claims description 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 5
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 claims description 5
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 4
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims description 4
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims description 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims description 4
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 125000005297 thienyloxy group Chemical group S1C(=CC=C1)O* 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 230000008635 plant growth Effects 0.000 claims description 3
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims description 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 2
- 125000002883 imidazolyl group Chemical group 0.000 claims description 2
- 230000003032 phytopathogenic effect Effects 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims description 2
- 125000006593 (C2-C3) alkynyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 description 183
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 41
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 39
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 35
- 239000000243 solution Substances 0.000 description 31
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 30
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- 239000007787 solid Substances 0.000 description 27
- 238000002360 preparation method Methods 0.000 description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
- 239000002904 solvent Substances 0.000 description 21
- 239000000725 suspension Substances 0.000 description 21
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 20
- 235000021307 Triticum Nutrition 0.000 description 18
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- 230000000694 effects Effects 0.000 description 16
- 241000196324 Embryophyta Species 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 15
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
- 150000001412 amines Chemical class 0.000 description 15
- 239000007788 liquid Substances 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 14
- 239000000047 product Substances 0.000 description 14
- 239000002585 base Substances 0.000 description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 240000005979 Hordeum vulgare Species 0.000 description 11
- 235000007340 Hordeum vulgare Nutrition 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 11
- 239000003921 oil Substances 0.000 description 11
- 239000004480 active ingredient Substances 0.000 description 10
- 239000008187 granular material Substances 0.000 description 10
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 10
- 235000019341 magnesium sulphate Nutrition 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 229920001817 Agar Polymers 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 9
- 240000003768 Solanum lycopersicum Species 0.000 description 9
- 239000008272 agar Substances 0.000 description 9
- 238000011534 incubation Methods 0.000 description 9
- 238000011081 inoculation Methods 0.000 description 9
- 230000003449 preventive effect Effects 0.000 description 9
- 238000005160 1H NMR spectroscopy Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 235000021391 short chain fatty acids Nutrition 0.000 description 8
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 7
- VKNVIMFQGNSLFW-UHFFFAOYSA-N 2-bromo-n-(2-methylpent-3-yn-2-yl)butanamide Chemical compound CCC(Br)C(=O)NC(C)(C)C#CC VKNVIMFQGNSLFW-UHFFFAOYSA-N 0.000 description 7
- 241000220225 Malus Species 0.000 description 7
- 240000007594 Oryza sativa Species 0.000 description 7
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- 244000105624 Arachis hypogaea Species 0.000 description 6
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 6
- 230000003213 activating effect Effects 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 6
- 235000021016 apples Nutrition 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 6
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 6
- 239000000741 silica gel Substances 0.000 description 6
- 229910002027 silica gel Inorganic materials 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 235000013311 vegetables Nutrition 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- ORIIXCOYEOIFSN-UHFFFAOYSA-N 1,3-benzothiazol-6-ol Chemical compound OC1=CC=C2N=CSC2=C1 ORIIXCOYEOIFSN-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 5
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- 125000003506 n-propoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 5
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- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 4
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 4
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- SAHAKBXWZLDNAA-UHFFFAOYSA-N 1,3-benzoxazol-6-ol Chemical compound OC1=CC=C2N=COC2=C1 SAHAKBXWZLDNAA-UHFFFAOYSA-N 0.000 description 3
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- 230000014759 maintenance of location Effects 0.000 description 1
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- YKSNLCVSTHTHJA-UHFFFAOYSA-L maneb Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S YKSNLCVSTHTHJA-UHFFFAOYSA-L 0.000 description 1
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- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 description 1
- BCTQJXQXJVLSIG-UHFFFAOYSA-N mepronil Chemical compound CC(C)OC1=CC=CC(NC(=O)C=2C(=CC=CC=2)C)=C1 BCTQJXQXJVLSIG-UHFFFAOYSA-N 0.000 description 1
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 description 1
- AFCCDDWKHLHPDF-UHFFFAOYSA-M metam-sodium Chemical compound [Na+].CNC([S-])=S AFCCDDWKHLHPDF-UHFFFAOYSA-M 0.000 description 1
- XWPZUHJBOLQNMN-UHFFFAOYSA-N metconazole Chemical compound C1=NC=NN1CC1(O)C(C)(C)CCC1CC1=CC=C(Cl)C=C1 XWPZUHJBOLQNMN-UHFFFAOYSA-N 0.000 description 1
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- CJPQIRJHIZUAQP-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(phenylacetyl)alaninate Chemical compound CC=1C=CC=C(C)C=1N(C(C)C(=O)OC)C(=O)CC1=CC=CC=C1 CJPQIRJHIZUAQP-UHFFFAOYSA-N 0.000 description 1
- CIEXPHRYOLIQQD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-2-furoylalaninate Chemical compound CC=1C=CC=C(C)C=1N(C(C)C(=O)OC)C(=O)C1=CC=CO1 CIEXPHRYOLIQQD-UHFFFAOYSA-N 0.000 description 1
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- AMSPWOYQQAWRRM-UHFFFAOYSA-N metrafenone Chemical compound COC1=CC=C(Br)C(C)=C1C(=O)C1=C(C)C=C(OC)C(OC)=C1OC AMSPWOYQQAWRRM-UHFFFAOYSA-N 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
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- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- BLCKKNLGFULNRC-UHFFFAOYSA-L n,n-dimethylcarbamodithioate;nickel(2+) Chemical compound [Ni+2].CN(C)C([S-])=S.CN(C)C([S-])=S BLCKKNLGFULNRC-UHFFFAOYSA-L 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 230000001069 nematicidal effect Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- JHIPUJPTQJYEQK-ZLHHXESBSA-N orysastrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1CO\N=C(/C)\C(=N\OC)\C(\C)=N\OC JHIPUJPTQJYEQK-ZLHHXESBSA-N 0.000 description 1
- UWVQIROCRJWDKL-UHFFFAOYSA-N oxadixyl Chemical compound CC=1C=CC=C(C)C=1N(C(=O)COC)N1CCOC1=O UWVQIROCRJWDKL-UHFFFAOYSA-N 0.000 description 1
- IOXAXYHXMLCCJJ-UHFFFAOYSA-N oxetan-3-yl 2-[(4,6-dimethylpyrimidin-2-yl)carbamoylsulfamoyl]benzoate Chemical compound CC1=CC(C)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC2COC2)=N1 IOXAXYHXMLCCJJ-UHFFFAOYSA-N 0.000 description 1
- 229960000321 oxolinic acid Drugs 0.000 description 1
- AMEKQAFGQBKLKX-UHFFFAOYSA-N oxycarboxin Chemical compound O=S1(=O)CCOC(C)=C1C(=O)NC1=CC=CC=C1 AMEKQAFGQBKLKX-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical group [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000003415 peat Substances 0.000 description 1
- OGYFATSSENRIKG-UHFFFAOYSA-N pencycuron Chemical compound C1=CC(Cl)=CC=C1CN(C(=O)NC=1C=CC=CC=1)C1CCCC1 OGYFATSSENRIKG-UHFFFAOYSA-N 0.000 description 1
- WBTYBAGIHOISOQ-UHFFFAOYSA-N pent-4-en-1-yl 2-[(2-furylmethyl)(imidazol-1-ylcarbonyl)amino]butanoate Chemical compound C1=CN=CN1C(=O)N(C(CC)C(=O)OCCCC=C)CC1=CC=CO1 WBTYBAGIHOISOQ-UHFFFAOYSA-N 0.000 description 1
- LKPLKUMXSAEKID-UHFFFAOYSA-N pentachloronitrobenzene Chemical compound [O-][N+](=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl LKPLKUMXSAEKID-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 150000003017 phosphorus Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- IBSNKSODLGJUMQ-SDNWHVSQSA-N picoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC(C(F)(F)F)=N1 IBSNKSODLGJUMQ-SDNWHVSQSA-N 0.000 description 1
- 235000002651 pink gum Nutrition 0.000 description 1
- 244000087877 pink gum Species 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- JPFWJDMDPLEUBD-ITJAGOAWSA-N polyoxorim Polymers O[C@@H]1[C@H](O)[C@@H]([C@H](NC(=O)[C@H]([C@H](O)[C@@H](O)COC(N)=O)N)C(O)=O)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 JPFWJDMDPLEUBD-ITJAGOAWSA-N 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001965 potato dextrose agar Substances 0.000 description 1
- 239000004493 powder for dry seed treatment Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 description 1
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical compound C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 description 1
- QXJKBPAVAHBARF-BETUJISGSA-N procymidone Chemical compound O=C([C@]1(C)C[C@@]1(C1=O)C)N1C1=CC(Cl)=CC(Cl)=C1 QXJKBPAVAHBARF-BETUJISGSA-N 0.000 description 1
- WZZLDXDUQPOXNW-UHFFFAOYSA-N propamocarb Chemical compound CCCOC(=O)NCCCN(C)C WZZLDXDUQPOXNW-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 description 1
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- FLVBXVXXXMLMOX-UHFFFAOYSA-N proquinazid Chemical compound C1=C(I)C=C2C(=O)N(CCC)C(OCCC)=NC2=C1 FLVBXVXXXMLMOX-UHFFFAOYSA-N 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 description 1
- JOOMJVFZQRQWKR-UHFFFAOYSA-N pyrazophos Chemical compound N1=C(C)C(C(=O)OCC)=CN2N=C(OP(=S)(OCC)OCC)C=C21 JOOMJVFZQRQWKR-UHFFFAOYSA-N 0.000 description 1
- ZLIBICFPKPWGIZ-UHFFFAOYSA-N pyrimethanil Chemical compound CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 ZLIBICFPKPWGIZ-UHFFFAOYSA-N 0.000 description 1
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- WRPIRSINYZBGPK-UHFFFAOYSA-N quinoxyfen Chemical compound C1=CC(F)=CC=C1OC1=CC=NC2=CC(Cl)=CC(Cl)=C12 WRPIRSINYZBGPK-UHFFFAOYSA-N 0.000 description 1
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- 239000013557 residual solvent Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- HCJLVWUMMKIQIM-UHFFFAOYSA-M sodium;2,3,4,5,6-pentachlorophenolate Chemical compound [Na+].[O-]C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl HCJLVWUMMKIQIM-UHFFFAOYSA-M 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- HFQQZARZPUDIFP-UHFFFAOYSA-M sodium;2-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O HFQQZARZPUDIFP-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- PUYXTUJWRLOUCW-UHFFFAOYSA-N spiroxamine Chemical compound O1C(CN(CC)CCC)COC11CCC(C(C)(C)C)CC1 PUYXTUJWRLOUCW-UHFFFAOYSA-N 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 235000021012 strawberries Nutrition 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- ROZUQUDEWZIBHV-UHFFFAOYSA-N tecloftalam Chemical compound OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C(=O)NC1=CC=CC(Cl)=C1Cl ROZUQUDEWZIBHV-UHFFFAOYSA-N 0.000 description 1
- XQTLDIFVVHJORV-UHFFFAOYSA-N tecnazene Chemical compound [O-][N+](=O)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl XQTLDIFVVHJORV-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- IOGXOCVLYRDXLW-UHFFFAOYSA-N tert-butyl nitrite Chemical compound CC(C)(C)ON=O IOGXOCVLYRDXLW-UHFFFAOYSA-N 0.000 description 1
- 239000012414 tert-butyl nitrite Substances 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 description 1
- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 description 1
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 1
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 1
- 229960002447 thiram Drugs 0.000 description 1
- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical compound N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 description 1
- HYVWIQDYBVKITD-UHFFFAOYSA-N tolylfluanid Chemical compound CN(C)S(=O)(=O)N(SC(F)(Cl)Cl)C1=CC=C(C)C=C1 HYVWIQDYBVKITD-UHFFFAOYSA-N 0.000 description 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- BAZVSMNPJJMILC-UHFFFAOYSA-N triadimenol Chemical compound C1=NC=NN1C(C(O)C(C)(C)C)OC1=CC=C(Cl)C=C1 BAZVSMNPJJMILC-UHFFFAOYSA-N 0.000 description 1
- IQGKIPDJXCAMSM-UHFFFAOYSA-N triazoxide Chemical compound N=1C2=CC=C(Cl)C=C2[N+]([O-])=NC=1N1C=CN=C1 IQGKIPDJXCAMSM-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- DQJCHOQLCLEDLL-UHFFFAOYSA-N tricyclazole Chemical compound CC1=CC=CC2=C1N1C=NN=C1S2 DQJCHOQLCLEDLL-UHFFFAOYSA-N 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 150000008648 triflates Chemical class 0.000 description 1
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 description 1
- HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 description 1
- RROQIUMZODEXOR-UHFFFAOYSA-N triforine Chemical compound O=CNC(C(Cl)(Cl)Cl)N1CCN(C(NC=O)C(Cl)(Cl)Cl)CC1 RROQIUMZODEXOR-UHFFFAOYSA-N 0.000 description 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 description 1
- JARYYMUOCXVXNK-CSLFJTBJSA-N validamycin A Chemical compound N([C@H]1C[C@@H]([C@H]([C@H](O)[C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)CO)[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O JARYYMUOCXVXNK-CSLFJTBJSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000004564 water dispersible powder for slurry treatment Substances 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 description 1
- DUBNHZYBDBBJHD-UHFFFAOYSA-L ziram Chemical compound [Zn+2].CN(C)C([S-])=S.CN(C)C([S-])=S DUBNHZYBDBBJHD-UHFFFAOYSA-L 0.000 description 1
- FJBGIXKIXPUXBY-UHFFFAOYSA-N {2-[3-(4-chlorophenyl)propyl]-2,4,4-trimethyl-1,3-oxazolidin-3-yl}(imidazol-1-yl)methanone Chemical compound C1=CN=CN1C(=O)N1C(C)(C)COC1(C)CCCC1=CC=C(Cl)C=C1 FJBGIXKIXPUXBY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- This invention relates to novel N-alkynyl-2-heteroaryloxyalkylamides, to processes for preparing them, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants.
- Various quinolin-8-oxyalkanecarboxylic acid derivatives are described as being useful as antidotes for herbicides or as herbicide safeners (see, for example, US 4,881,966, US 4,902,340 and US 5,380,852).
- Certain pyridyl- and pyrimidinyloxy- ' (thio)alkanoic acid amide derivatives are described in, for example, WO 99/33810 and US 6090815, together with their use as agricultural and horticultural fungicides.
- certain phenoxyalkanoic acid amide derivatives are described in, for example, US 4116677 and US 4168319, together with their use as herbicides and mildewicides.
- Het is a 5- or 6- linked group of the formula (a) or (b):
- X is ⁇ , ⁇ H or ⁇ -C 1-4 alkyl
- Y is CR, N, NH, N-C M alkyl, O or S
- Z is CR, N, NH, N-C ⁇ - 4 alkyl, O or S
- R is H, halo, C 1-4 alkyl, C 1- alkoxy, C 1-4 alkylthio, C 1-4 alkylsulphinyl, .
- alkylsulphonyl halo(C ⁇ - 4 )alkyl or halo(C 1-4 )alkoxy, halo(C 1-4 )alkylthio, halo(C 1-4 )alkyl- sulphinyl, halo(C ⁇ -4 )alkylsulphonyl or mono- or di-(C 1- ) alkyla ino
- bonds joining X, Y, Z and the fused benzene ring are double or single bonds appropriate to the valencies of X, Y and Z, provided that only one of Y and Z may be O or S, that only one of Y and Z may be CR and that only one of X, Y and Z may be NH or N-C ⁇ -4 alkyl;
- Ri is C 1-4 alkyl, C -4 alkenyl or C 2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms (e.g. 2,2,2-trifluoroethyl), with a cyano group (e.g. cyanomethyl), with a C ⁇ - alkylcarbonyl group (e.g. acetylmethyl), with a C 1-4 alkoxycarbonyl group (e.g. methoxycarbonylmethyl and methoxycarbonylethyl) or with a hydroxy group (e.g.
- R t is alkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl in which the ' total number of carbon atoms is 2 or 3 (e.g. methoxymethyl, methylthiomethyl, ethoxy- methyl, 2-methoxyethyl and 2-methylthioethyl), or
- Ri is a straight-chain Cj -4 alkoxy group (i.e. methoxy, ethoxy, n-propoxy and /z-butoxy);
- R 2 is H, C 1- alkyl, C alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C 1-4 alkoxy;
- R 3 and R 4 are independently H, C 1-3 alkyl, C 2-3 alkenyl or C M alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or
- R 3 and ⁇ join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one O, S or N atom and optionally substituted with halo or C 1-4 alkyl;
- R 5 is H, C alkyl or C 3 . 6 cycloalkyl in which the alkyl or cycloalkyl group is optionally substituted with halo, hydroxy, C 1-6 alkoxy, cyano, C 1- alkylcarbonyloxy, aminocarbonyloxy or mono- or di(C 1-4 )alkylaminocarbonyloxy, -S(O) n (C 1-6 )alkyl where n is 0, 1 or 2, triazolyl (e.g.
- R 5 is optionally substituted phenyl, optionally substituted thienyl or optionally substituted benzyl, in which the optionally substituted phenyl and thienyl rings or moieties of the R 5 values are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto, C 1-4 alkyl, C 2-4 , alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 2- alkenyloxy, C 2-4 alkynyloxy, halo (C 1- )alkyl, halo(C 1-4 )alkoxy, -S(O) m (C
- the invention includes compounds as defined above where R 5 is other than H.
- the compounds of the invention contain at least one asymmetric carbon atom (and at least two when R 3 and ⁇ are different) and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. However, these mixtures may be separated into individual isomers or isomer pairs, and this invention embraces such isomers and mixtures thereof in all proportions. It is to be expected that for any given compound, one isomer may be more fungicidally active than another.
- alkyl groups and alkyl moieties of alkoxy, alkylthio, etc. suitably contain from 1 to 4 carbon atoms in the form of straight or branched chains. Examples are methyl, ethyl, n-and z ' so-propyl and n-, sec-, iso- and tert- butyl. Where alkyl moieties contain 5 or 6 carbon atoms, examples are «-pentyl and n- hexyl.
- Alkenyl and alkynyl moieties also suitably contain from 2 to 4 carbon atoms in the form of straight or branched chains. Examples are allyl, ethynyl and propargyl.
- Halo includes fluoro, chloro, bromo and iodo. Most commonly it is fluoro, chloro or bromo and usually fluoro or chloro.
- this invention provides a compound of the general formula (1) wherein Het is a 5- or 6- linked group of the formula:
- W is H, halo, C 1-4 alkyl, C M alkoxy, halo(C ⁇ - )alkyl or halo(Ci -4 )alkoxy,
- X is N, NH or N-C 1-4 alkyl
- Y is CH, N, NH, O or S
- Z is CH, N, NH, N-C M alkyl, O or S, and the bonds joining X, Y, Z and the fused benzene ring are double or single bonds appropriate to the valencies of X, Y and Z, provided that only one of Y and Z may be O or S, that only one of Y and Z may be CH and that only one of X, Y and Z may be NH or
- Ri is C ⁇ -4 alkyl, C 2-4 alkenyl or C -4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms (e.g. 2,2,2-trifluoroethyl), with a cyano group (e.g. cyanomethyl), with a
- C ⁇ - alkylcarbonyl group e.g. acetylmethyl
- a C ⁇ -4 alkoxycarbonyl group e.g. methoxycarbonylmethyl and methoxycarbonylethyl
- a hydroxy group e.g. hydroxymethyl
- Ri is alkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl in which the total number of carbon atoms is 2 or 3 (e.g. methoxymethyl, methylthiomethyl, ethoxymethyl, 2-methoxyethyl and 2-methylthioethyl), or
- Ri is a straight-chain C 1-4 alkoxy group (i.e. methoxy, ethoxy, n-propoxy and n-butoxy);
- R 2 is H, C 1- alkyl, C alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C ⁇ -4 alkoxy;
- R 3 and R 4 are independently H, C 1-3 alkyl, C 2- alkenyl or C 2 . 3 alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or R 3 and R 4 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one O, S or N atom and optionally substituted with halo or C 1-4 alkyl;
- R 5 is H, C ⁇ -4 alkyl or C 3-6 cycloalkyl in which the alkyl or cycloalkyl group is optionally substituted with halo, hydroxy, C ⁇ _ 6 alkoxy, cyano, C ⁇ -4 alkylcarbonyloxy, amino- carbonyloxy or mono- or di(C 1-4 )alkylaminocarbonyloxy, tri(C 1-4 )alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy, or
- R 5 is optionally substituted phenyl, optionally substituted thienyl or optionally substituted benzyl, in which the optionally substituted phenyl and thienyl rings or moieties of the R 5 values are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto, C 1-4 alkyl, C 2 . 4 , alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 2-4 alkenyloxy, C 2 .
- the invention includes compounds as defined above where R 5 is other than H.
- Typical of Het are groups, linked in the position shown, of the formula:
- W is H, halo, C 1- alkyl, C ⁇ - alkoxy, C 1-4 alkylthio, . 4 alkylsulphinyl, C 1-4 alkylsulphonyl, halo(C ⁇ -4 )alkyl, halo(C 1- )alkoxy, halo(C 1-4 )alkylthio, halo(C ⁇ - )alkyl- sulphinyl, halo(C ⁇ - )alkylsulphonyl, cyano or nitro, and
- X is N
- Y is CR
- Z is O, S, NH or N-C alkyl
- R is H, halo, C ⁇ -4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, halo(C 1-4 )alkyl or halo- (C 1-4 )alkoxy, halo(C 1-4 )alkylthio, halo(C ⁇ -4 )alkylsulphinyl, halo(C ⁇ - )alkylsulphonyl or mono- or di-(C 1-4 ) alkylamino, the X-Y bond being a double bond while the Y-Z bond and the bonds joining X and Z to the benzene ring are single bonds; or
- X and Y are N and Z is O, S, NH or N- -4 alkyl, the X-Y bond being a double bond while the Y-Z bond and the bonds joining X and Z to the benzene ring are single bonds; or
- X is N
- Y is O, S, NH or N-C 1-4 alkyl
- Z is CR
- R is H, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1- alkylthio, C 1- alkylsulphinyl, C ⁇ -4 alkylsulphonyl, halo(C 1-4 )alkyl or halo- (C ⁇ _ )alkoxy, halo(C ⁇ -4 )alkylthio, halo(C 1-4 )alkylsulphinyl, halo(C 1- )alkylsulphonyl or mono- or di-(C 1- ) alkylamino, the X-Y and Y-Z bonds being single bonds while the bonds joining X and Z to the benzene ring are double bonds; or
- X is NH or N-C ⁇ _ 4 -alkyl
- Y is N
- Z is CR
- R is H, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, halo(C 1- )alkyl or halo(C 1-4 )- alkoxy, halo(C 1 .
- W is H, halo, C 1- alkyl, C 1-4 alkoxy, halo(C 1- )alkyl or halo(C 1-4 )alkoxy, and
- X is N
- Y is CH
- Z is O
- S NH or N-C alkyl
- the X-Y bond being a double bond while the Y-Z bond and the bonds joining X and Z to the benzene ring are single bonds
- X and Y are N and Z is O, S, NH or N-C 1-4 alkyl, the X-Y bond being a double bond while the Y-Z bond and the bonds joining X and Z to the benzene ring are single bonds; or (3) X is N, Y is O, S or NH and Z is CH, the X-Y and Y-Z bonds being single bonds while the bonds joining X and Z to the benzene ring are double bonds; or (4) X is NH or N-Q -4 alkyl, Y is N and Z is CH, the Y-Z bond being a double bond while the Y-Z bond and the bonds joining X and Z to the benzene ring are single bonds.
- Het are 5- and 6-benzothiazolyl optionally bearing a 2-C substituent, 5- and 6-(2,l-benzisothiazolyl) optionally bearing a 3-C substituent, 5- and 6-benzoxazolyl optionally bearing a 2-C substituent, 5- and 6-(2,l-benzisoxazolyl) optionally bearing a 3-C substituent, 5- and 6-(lH-benzimidazolyl) optionally bearing a 2-C substituent and optionally bearing a N-C ⁇ _ 4 alkyl substituent, 5- and 6-(lH-indazolyl) optionally bearing a 3-C substituent and optionally bearing a N-C 1-4 alkyl substituent, 5- and 6-(2H-indazolyl) optionally bearing a 3-C substituent and optionally bearing a N-C 1- alkyl substituent, 5- and 6-(l,2,3-benzothiadiazolyl), 5- and 6-(l,2,3-benzoxadiazolyl), 5- and 6-(lH-benzotrime
- ⁇ et is selected from the group consisting of 5- and 6-benzothiazolyl, 5- and 6-(2,l-benzisothiazolyl), 5- and 6-benzoxazolyl, 5- and 6-(2,l-benzisoxazolyl), 5- and 6-(lH-benzimidazolyl) optionally bearing a N-C 1-4 alkyl substituent, 5- and 6-(lH-indazolyl) optionally bearing a N-C ⁇ -4 alkyl substituent, 5- and 6-(2H-indazolyl), 5- and 6-(l,2,3-benzothiadiazolyl), 5- and 6-(l,2,3- benzoxadiazolyl), 5- and 6-(lH-benzotriazolyl) optionally bearing a N-C 1-4 alkyl substituent, 5-(2H-benzotriazolyl), 5-(2,l,3-benzothiadiazolyl) and 5-(2,l,3-benzoxa- diazolyl).
- Het is 5- or 6-benzothiazolyl, 5- (2,1-benzisothiazolyl), 6-benzoxazolyl, 5-(2,l-benzisoxazolyl), 6-(lH-benzimidazolyl) optionally bearing a N-C 1-4 alkyl substituent, 5-(lH-indazolyl) optionally bearing a N-C 1-4 alkyl substituent, 6-(l,2,3-benzothiadiazolyl) or 6-(l,2,3-benzoxadiazolyl).
- ⁇ et is 6-benzoxazolyl optionally bearing a 2-C substituent or 6-benzothiazolyl optionally bearing a 2-C substituent, particularly the latter, wherein any of the foregoing optional substitutents is selected from halo, C ⁇ -4 alkyl, C M alkoxy, C 1-4 alkylthio, C 1-4 alkylsulphinyl, C 1- alkylsulphonyl, halo- (C 1-4 )alkyl or halo(C ⁇ - )alkoxy, halo(C ⁇ -4 )alkylthio, halo(C ⁇ -4 )alkylsulphinyl, halo(C 1-4 )- alkylsulphonyl or mono- or di-(C ⁇ -4 ) alkylamino.
- ⁇ et is 6-benzoxazolyl or 6- benzothiazolyl, particularly the latter.
- ⁇ -C 1-4 alkyl value of X, Y and Z is N-methyl.
- Ri is methyl, ethyl, n-propyl, 2,2,2-trifluoromethyl, cyanomethyl, acetylmethyl, methoxycarbonylmethyl, methoxycarbonylethyl, hydroxymethyl, hydroxy- ethyl, methoxymethyl, methylthiomethyl, ethoxymethyl, 2-methoxyethyl, 2-methylthio- ethyl, methoxy, ethoxy, n-propoxy or n-butoxy.
- Ethyl is a prefe ⁇ ed value of Ri but also of particular interest are methoxy, ethoxy and methoxymethyl.
- R 2 is ⁇ and at least one, but preferably both of R 3 and R 4 are methyl.
- R 3 and R When one of R 3 and R is ⁇ , the other may be methyl, ethyl or n- or zs ⁇ -propyl.
- R 3 and R 4 When one of R 3 and R 4 is methyl, the other may be ⁇ or ethyl but is preferably also methyl.
- R also includes C 1- alkoxymethyl and benzyloxymethyl in which the phenyl ring of the benzyl group optionally carries an alkoxy substituent, e.g. a methoxy substituent.
- Such values of R provide compounds of formula (1) that are believed to be pro-pesticidal compounds.
- R 5 is ⁇ or methyl, preferably methyl.
- R 5 is hydroxymethyl, methoxymethyl, 1-methoxyethyl, 3- cyano-rc-propyl and tert-butyldimethylsiloxymethyl.
- the invention provides a compound of the general formula (1) wherein Het is 5- or 6-benzothiazolyl optionally bearing a 2-C substituent, 5-(2,l- benzisothiazolyl) optionally bearing a 3-C substituent, 6-benzoxazolyl optionally bearing a 2-C substituent, 5-(2,l-benzisoxazolyl) optionally bearing a 3-C substituent, 6-(lH- benzimidazolyl) optionally bearing a 2-C substituent and optibnally bearing a N-C 1-4 alkyl substituent, 5-(lH-indazolyl) optionally bearing a 3-C substitutent and optionally bearing a N-C ⁇ _ 4 alkyl substituent, 6-(l,2,3-benzothiadiazolyl) or 6-(l,2,3-benzoxa- diazolyl), wherein any of the foregoing optional substituents are selected from halo, C 1-4 alkyl, C ⁇ _ 4 alkoxy, - alky
- the invention includes compounds as defined above where R 5 is other than ⁇ .
- the invention provides a compound of the general formula (1) wherein ⁇ et is 5- or 6-benzothiazolyl, 5-(2,l-benzisothiazolyl), 6-benzoxazolyl, 5- (2,1-benzisoxazolyl), 6-(lH-benzimidazolyl) optionally bearing a N-C 1- alkyl substituent, 5-(lH-indazolyl) optionally bearing a N-C 1- alkyl substituent, 6-(l,2,3- benzothiadiazolyl) or 6-(l,2,3-benzoxadiazolyl);
- Ri is methyl, ethyl, n-propyl, 2,2,2-tri- fluoromethyl, cyanomethyl, acetylmethyl, methoxycarbonylmethyl, methoxycarbonyl- ethyl, hydroxymethyl, hydroxyethyl, methoxymethyl, methylthiomethyl, ethoxymethyl
- Tables 1 to 62 Compounds that form part of the invention are illustrated in Tables 1 to 62 below.
- the compounds in Table 1 are of the general formula (1) where Het is 6-benzothiazolyl, Ri is ethyl, R 2 is H, R and R 4 are both methyl and R 5 has the values given in the table.
- Table 1
- Table 2 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methyl, R 2 is hydrogen, R and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 2 is the same as compound 1 of Table 1 except that in compound 1 of Table 2 Ri is methyl instead of ethyl.
- compounds 2 to 92 of Table 2 are the same as compounds 2 to 92 of Table 1 , respectively, except that ⁇ in the compounds of Table 2 Ri is methyl instead of ethyl.
- Table 3 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is n-propyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3 Ri is n-propyl instead of ethyl.
- compounds 2 to 92 of Table 3 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 3 Ri is n-propyl instead of ethyl.
- Table 4 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is n-propyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3 Ri is n-propyl instead of ethyl.
- Table 4 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is 2,2,2-trifluoroethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4 Ri is 2,2,2-trifluoroethyl instead of ethyl.
- compounds 2 to 92 of Table 4 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 4 Ri is 2,2,2-trifluoroethyl instead of ethyl.
- Table 5 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is 2,2,2-trifluoroethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4 Ri is 2,2,
- Table 5 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, R ⁇ is cyanomethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 Ri is cyanomethyl instead of ethyl.
- compounds 2 to 92 of Table 5 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 5 Ri is cyanomethyl instead of ethyl.
- Table.6 Table 6 consists of 92 compounds of the general formula (1), where Het is 6-benzothia- zolyl, Ri is acetylmethyl, R is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 6 is the same as compound 1 of Table 1 except that in compound 1 of Table 6 Ri is acetylmethyl instead of ethyl.
- compounds 2 to 92 of Table 6 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 2 Ri is acetylmethyl instead of ethyl.
- Table 7
- Table 7 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methoxycarbonylmethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 7 is the same as compound 1 of Table 1 except that in compound 1 of Table 7 Ri is methoxycarbonylmethyl instead of ethyl.
- compounds 2 to 92 of Table 7 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 7 Ri is methoxycarbonylmethyl instead of ethyl.
- Table 8 consists of 92 compounds of the general formula (1), where Het is 6-benzothia- zolyl, Ri is methoxycarbonylethyl, R 2 is hydrogen, R 3 and * are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 8 is the same as compound 1 of Table 1 except that in compound 1 of Table 8 Rj is methoxycarbonylethyl instead of ethyl.
- compounds 2 to 92 of Table 8 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 8 Ri is methoxycarbonylethyl instead of ethyl.
- Table 9
- Table 9 consists of -92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is hydroxymethyl, R 2 is hydrogen, R 3 and R A are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 9 is the same as compound 1 of Table 1 except that in compound 1 of Table 9 Ri is hydroxymethyl instead of ethyl.
- compounds 2 to 92 of Table 9 are the same as compounds 2 to 92 of Table 1 , respectively, except that in the compounds of Table 9 Ri is hydroxymethyl instead of ethyl.
- Table 10 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is hydroxethyl, R is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 10 is the same as compound 1 of Table 1 except that in compound 1 of Table 10 Ri is hydroxyethyl instead of ethyl.
- compounds 2 to 92 of Table 10 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 10 Ri is hydroxyethyl instead of ethyl.
- Table 11
- Table 11 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methoxymethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 11 is the same as compound 1 of Table 1 except that in compound 1 of Table 11 Ri is methoxymethyl instead of ethyl.
- compounds 2 to 92 of Table 11 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 11 Ri is methoxymethyl instead of ethyl.
- Table 12
- Table 12 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methylthiomethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 12 is the same as compound 1 of Table 1 except that in compound 1 of Table 12 Ri is methylthiomethyl instead of ethyl.
- compounds 2 to 92 of Table 12 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 12 Ri is methylthiomethyl instead of ethyl.
- Table 13
- Table 13 consists of 92 compounds of the general formula (1), where Het is 6-benzothia- zolyl, Ri is ethoxymethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 13 is the same as compound 1 of Table 1 except that in compound 1 of Table 13 Ri is ethoxymethyl instead of ethyl.
- compounds 2 to 92 of Table 13 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 13 Ri is ethoxymethyl instead of ethyl.
- Table 14
- Table 14 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is 2-methoxyethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 14 is the same as compound 1 of Table 1 except that in compound 1 of Table 14 Ri is 2-methoxyethyl instead of ethyl.
- compounds 2 to 92 of Table 14 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 14 Ri is 2-methoxyethyl instead of ethyl.
- Table 15 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is 2-methythioethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 15 is the same as compound 1 of Table 1 except that in compound 1 of Table 15 Ri is 2-methythioethyl instead of ethyl.
- compounds 2 to 92 of Table 15 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 15 Ri is 2-methythioethyl instead of ethyl.
- Table 16
- Table 16 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 16 is the same as compound 1 of Table 1 except that in compound 1 of Table 16 Ri is methoxy instead of ethyl.
- compounds 2 to 92 of Table 16 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 16 Ri is methoxy instead of ethyl.
- Table 17 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is methoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- Table 17 consists of 92 compounds of the general formula (1), where Het is 6-benzothia- zolyl, Ri is ethoxy, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 17 is the same as compound 1 of Table 1 except that in compound 1 of Table 17 Ri is ethoxy instead of ethyl.
- compounds 2 to 92 of Table 17 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 17 Ri is ethoxy instead of ethyl.
- Table 18
- Table 18 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is n-propoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 18 is the same as compound 1 of Table 1 except that in compound 1 of Table 18 Ri is n-propoxy instead of ethyl.
- compounds 2 to 92 of Table 18 are the same as compounds 2 to 92 of Table 1 , respectively, except that in the compounds of Table 18 Ri is n-propoxy instead of ethyl.
- Table 19 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is n-propoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 18 is the same as compound 1 of Table 1 except that in compound 1 of Table 18 Ri is n-propoxy instead of ethyl.
- Table 19 consists of 92 compounds of the general formula (1), where Het is 6-benzothiazolyl, Ri is n-butoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 19 is the same as compound 1 of Table 1 except that in compound 1 of Table 19 Ri is n-butoxy instead of ethyl.
- compounds 2 to 92 of Table 19 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 19 Ri is n-butoxy instead of ethyl.
- Table 20 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 20 is the same as compound 1 of Table 1 except that in compound 1 of Table 20 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 20 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 20 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 21
- Table 21 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is methyl, R 2 is hydrogen, R 3 and R ⁇ t are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 21 is the same as compound 1 of Table 2 except that in compound 1 of Table 21 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 21 are the same as compounds 2 to 92 of Table 2, respectively, except that in the compounds of Table 21 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 22 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is n-propyl, R 2 is hydrogen, R 3 and 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 22 is the same as compound 1 of Table 3 except that in compound 1 of Table 22 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 22 are the same as compounds 2 to 92 of Table 3, respectively, except that in the compounds of Table 22 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 23
- Table 23 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is 2,2,2-trifluoroethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 23 is the same as compound 1 of Table 4 except that in compound 1 of Table 23 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 23 are the same as compounds 2 to 92 of Table 4, respectively, except that in the compounds of Table 23 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 24 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is 2,2,2-trifluoroethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 23 is the same as compound 1 of Table 4 except that in compound 1 of Table 23 Het is 5-benzo
- Table 24 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is cyanomethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 24 is the same as compound 1 of Table 5 except that in compound 1 of Table 24 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 24 are the same as compounds 2 to 92 of Table 5, respectively, except that in the compounds of Table 24 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 25 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is cyanomethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 24 is the same as compound 1 of Table 5 except that in compound 1 of Table 24 Het is 5-benzothiazolyl instead of 6- benzothiazoly
- Table 25 consists of 92 compounds of the general formula (1), where Het is 5-benzothia- zolyl, Ri is acetylmethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 25 is the same as compound 1 of Table 6 except that in compound 1 of Table 25 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 25 are the same as compounds 2 to 92 of Table 6, respectively, except that in the compounds of Table 25 Het is 5-benzo- thiazolyl instead of 6-benzothiazolyl.
- Table 26
- Table 26 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, R ⁇ is methoxycarbonylmethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 26 is the same as compound 1 of Table 7 except that in compound 1 of Table 26 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 26 are the same as compounds 2 to 92 of Table 7, respectively, except that in the compounds of Table 26 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 27 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is methoxycarbonylethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 27 is the same as compound 1 of Table 8 except that in compound 1 of Table 27 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 27 are the same as compounds 2 to 92 of Table 8, respectively, except that in the compounds of Table 27 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 28
- Table 28 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is hydroxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 28 is the same as compound 1 of Table 9 except that in compound 1 of Table 28 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 28 are the same as compounds 2 to 92 of Table 9, respectively, except that in the compounds of Table 28 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 29 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is hydroxethyl, R 2 is hydrogen, R 3 and R 4 arp both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 29 is the same as compound 1 of Table 10 except that in compound 1 of Table 29 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 29 are the same as compounds 2 to 92 of Table 10, respectively, except that in the compounds of Table 29 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 30
- Table 30 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is methoxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 30 is the same as compound 1 of Table 11 except that in compound 1 of Table 30 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 30 are the same as compounds 2 to 92 of Table 11, respectively, except that in the compounds of Table 30 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 31 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is methoxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 30 is the same as compound 1 of Table 11 except that in compound 1 of Table 30 Het is 5-benzothiazolyl instead of 6- benzothiazoly
- Table 31 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, R] is methylthiomethyl, R 2 is hydrogen, R 3 and ⁇ are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 31 is the same as compound 1 of Table 12 except that in compound 1 of Table 31 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 31 are the same as compounds 2 to 92 of Table 12, respectively, except that in the compounds of Table 31 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 32 consists of 92 compounds of the general formula (1), where Het is 5-benzothia- zolyl, Ri is ethoxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 32 is the same as compound 1 of Table 13 except that in compound 1 of Table 32 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 32 are the same as compounds 2 to 92 of Table 13, respectively, except that in the compounds of Table 32 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 33 consists of 92 compounds of the general formula (1), where Het is 5-benzothia- zolyl, Ri is ethoxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 32 is the same as compound 1 of Table 13 except that in compound 1 of Table 32 Het is 5-benzothiazolyl
- Table 33 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is 2-methoxyethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 33 is the same as compound 1 of Table 14 except that in compound 1 of Table 33 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 33 are the same as compounds 2 to 92 of Table 14, respectively, except that in the compounds of Table 33 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 34 consists of 92 compounds of the general formula (1), where Het is 5-benzothia- zolyl, Ri is 2-methylthioethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 34 is the same as compound 1 of Table 15 except that in compound 1 of Table 34 Het is 5-benzothiazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 34 are the same as compounds 2 to 92 of Table 15, respectively, except that in the compounds of Table 34 Het is 5-benzo- thiazolyl instead of 6-benzothiazolyl.
- Table 35
- Table 35 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is methoxy, R 2 is hydrogen, R 3 and ⁇ are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 35 is the same as compound 1 of Table 16 except that in compound 1 of Table 35 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 35 are the same as compounds 2 to 92 of Table 16, respectively, except that in the compounds of Table 35 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 36 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is ethoxy, R 2 is hydrogen, R 3 and R ⁇ are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 36 is the same as compound 1 of Table 17 except that in compound 1 of Table 36 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 36 are the same as compounds 2 to 92 of Table 17, respectively, except that in the compounds of Table 36 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 37
- Table 37 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is n-propoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 37 is the same as compound 1 of Table 18 except that in compound 1 of Table 37 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 37 are the same as compounds 2 to 92 of Table 18, respectively, except that in the compounds of Table 37 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 38 consists of 92 compounds of the general formula (1), where Het is 5-benzothiazolyl, Ri is n-butoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 38 is the same as compound 1 of Table 19 except that in compound 1 of Table 38 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 38 are the same as compounds 2 to 92 of Table 19, respectively, except that in the compounds of Table 38 Het is 5-benzothiazolyl instead of 6-benzothiazolyl.
- Table 39 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 39 is the same as compound 1 of Table 1 except that in compound 1 of Table 39 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 39 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 39 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 40 Table 40 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 40 is the same as compound 1 of Table 2 except that in compound 1 of Table 40 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 40 are the same as compounds 2 to 92 of Table 2, respectively, except that in the compounds of Table 40 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 41
- Table 41 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is n-propyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 41 is the same as compound 1 of Table 3 except that in compound 1 of Table 41 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 41 are the same as compounds 2 to 92 of Table 3, respectively, except that in the compounds of Table 41 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 42
- Table 42 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is 2,2,2-trifluoroethyl, R is hydrogen, R and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 42 is the same as compound 1 of Table 4 except that in compound 1 of Table 42 Het is 6-benzoxazolyl instead of 6-benzo- thiazolyl.
- compounds 2 to 92 of Table 42 are the same as compounds 2 to 92 of Table 4, respectively, except that in the compounds of Table 42 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 43
- Table 43 consists of 92 compounds of the general formula (1), where Het is 6-benzoxa- zolyl, Ri is cyanomethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 43 is the same as compound 1 of Table 5 except that in compound 1 of Table 43 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 43 are the same as compounds 2 to 92 of Table 5, respectively, except that in the compounds of Table 43 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 44
- Table 44 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Rj is acetylmethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 44 is the same as compound 1 of Table 6 except that in compound 1 of Table 44 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 44 are the same as compounds 2 to 92 of Table 6, respectively, except that in the compounds of Table 44 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 45 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methoxycarbonylmethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 45 is the same as compound 1 of Table 7 except that in compound 1 of Table 45 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 45 are the same as compounds 2 to 92 of Table 7, respectively, except that in the compounds of Table 45 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 46
- Table 46 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methoxycarbonylethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 46 is the same as compound 1 of Table 8 except that in compound 1 of Table 46 Het is 6-benzoxazolyl instead of 6-benzo- thiazolyl.
- compounds 2 to 92 of Table 46 are the same as compounds 2 to 92 of Table 8, respectively, except that in the compounds of Table 46 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 47 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is hydroxymethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 47 is the same as compound 1 of Table 9 except that in compound 1 of Table 47 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 47 are the same as compounds 2 to 92 of Table 9, respectively, except that in the compounds of Table 47 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 48
- Table 48 consists of 92 compounds of the general formula (1), where X is Het is 6-benzoxazolyl, Ri is hydroxethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 48 is the same as compound 1 of Table 10 except that in compound 1 of Table 48 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 48 are the same as compounds 2 to 92 of Table 10, respectively, except that in the compounds of Table 48 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 49 consists of 92 compounds of the general formula (1), where X is Het is 6-benzoxazolyl, Ri is hydroxethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 48 is the same as compound 1 of Table 10 except that in compound 1 of Table 48 Het is 6-benzoxazolyl
- Table 49 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methoxymethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 49 is the same as compound 1 of Table 11 except that in compound 1 of Table 49 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 49 are the same as compounds 2 to 92 of Table 11, respectively, except that in the compounds of Table 49 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 50 consists of 92 compounds of the general formula (1), where Het is 6-benzoxa- zolyl, Ri is methylthiomethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 50 is the same as compound 1 of Table 12 except that in compound 1 of Table 50 Het is 6-benzoxazolyl instead of 6- benzofhiazolyl.
- compounds 2 to 92 of Table 50 are the same as compounds 2 to 92 of Table 12, respectively, except that in the compounds of Table 50 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 51
- Table 51 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is ethoxymethyl, R 2 is hydrogen, R 3 and R are both methyl and R5 has the values listed in Table 1.
- compound 1 of Table 51 is the same as compound 1 of Table 13 except that in compound 1 of Table 51 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 51 are the same as compounds 2 to 92 of Table 13, respectively, except that in the compounds of Table 51 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 52 consists of 92 compounds of the general formula (1), where Het is 6-benzoxa- zolyl, Ri is 2-methoxyethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R5 has the values listed in Table 1.
- compound 1 of Table 52 is the same as compound 1 of Table 14 except that in compound 1 of Table 52 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 52 are the same as compounds 2 to 92 of Table 14, respectively, except that in the compounds of Table 52 Het is 6-benzo- xazolyl instead of 6-benzothiazolyl.
- Table 53
- Table 53 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is 2-methylthioethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 53 is the same as compound 1 of Table 15 except that in compound 1 of Table 53 Het is 6-benzoxazolyl instead of 6- benzothiazolyl.
- compounds 2 to 92 of Table 53 are the same as compounds 2 to 92 of Table 15, respectively, except that in the compounds of Table 53 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 54 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 54 is the same as compound 1 of Table 16 except that in compound 1 of Table 54 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 54 are the same as compounds 2 to 92 of Table 1 , respectively, except that in the compounds of Table 16 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 55 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is methoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 54 is the same as compound 1 of Table 16 except that in compound 1 of Table 54 Het is 6-benzoxazolyl instead of 6-benzothiazoly
- Table 55 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is ethoxy, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 55 is the same as compound 1 of Table 17 except that in compound 1 of Table 55 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 55 are the same as compounds 2 to 92 of Table 17, respectively, except that in the compounds of Table, 55 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 56 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is n-propoxy, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 56 is the same as compound 1 of Table 18 except that in compound 1 of Table 56 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 56 are the same as compounds 2 to 92 of Table 18, respectively, except that in the compounds of Table 56 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 57 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, Ri is n-propoxy, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 56 is the same as compound 1 of Table 18 except that in compound 1 of Table 56 Het is 6-benzoxazolyl instead of 6-benzothiazo
- Table 57 consists of 92 compounds of the general formula (1), where Het is 6-benzoxazolyl, R ⁇ >is n-butoxy, R 2 is hydrogen, R 3 and ⁇ are both methyl and R 5 has the values listed in.Table 1.
- compound 1 of Table 57 is the same as compound 1 of Table 19 except that in compound 1 of Table 57 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 57 are the same as compounds 2 to 92 of Table 19, respectively, except that in the compounds of Table 57 Het is 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 58 consists of 92 compounds of the general formula (1), where Het is 2-mefhyl-6- benzothiazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 58 is the same as compound 1 of Table 1 except that in compound 1 of Table 58 Het is 2-methyl-6-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 58 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 58
- Het is 2-methyl-6-benzothiazolyl instead of 6-benzothiazolyl.
- Table 59 consists of 92 compounds of the general formula (1), where Het is 2-methyl- amino-6-benzothiazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 59 is the same as compound 1 of Table 1 except that in compound 1 of Table 59 Het is 2-methylamino-6-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 59 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 59 Het is 2-methylamino-6-benzothiazolyl instead of 6-benzothiazolyl.
- Table 60
- Table 60 consists of 92 compounds of the general formula (1), where Het is 2-chloro-6- benzothiazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 60 is the same as compound 1 of Table 1 except that in compound 1 of Table 60 Het is 2-chloro-6-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to .92 of Table 60 are the same as compounds 2 to 92 of Table 1, respectively, except that in the compounds of Table 60 Het is 2-chloro-6-benzothiazolyl instead of 6-benzothiazolyl.
- Table 61 consists of 92 compounds of the general formula (1), where Het is 2-methyl-6- benzoxazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 61 is the same as compound 1 of Table 1 except that in compound 1 of Table 61 Het is 2-methyl-6-benzoxazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 61 are the same as compounds 2 to 92 of Table 1 classroom respectively, except that in the compounds of Table 61 Het is 2-methyl- 6-benzoxazolyl instead of 6-benzothiazolyl.
- Table 62 is the general formula (1), where Het is 2-methyl-6- benzoxazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 61 is the same as compound 1 of Table 1 except that in compound 1 of Table 61 He
- Table 62 consists of 92 compounds of the general formula (1), where Het is 2-methyl-5- benzothiazolyl, Ri is ethyl, R 2 is hydrogen, R 3 and R 4 are both methyl and R 5 has the values listed in Table 1.
- compound 1 of Table 62 is the same as compound 1 of Table 1 except that in compound 1 of Table 62 Het is 2-methyl-5-benzothiazolyl instead of 6-benzothiazolyl.
- compounds 2 to 92 of Table 62 are the same as compounds 2 to 92 of Table 1, -respectively, except that in the compounds of Table 62 Het is 2-methyl-5-benzothiazolyl instead of 6-benzothiazolyl.
- the compounds of formula (1) may be prepared as outlined in Schemes 1 to 9 below in which Het, W, X, Y, Z, Ri, R 2 , R 3 , R 4 and R 5 have the meanings given above, R 6 is straight-chain C 1- alkyl, R 7 , R 8 and R 9 are independently H or C 1-4 alkyl, L is a leaving group such as a halide, for example iodide, an alkyl- or arylsulphonyloxy group, for example methylsulphonyloxy and tosyloxy or a triflate, Hal is halogen, R a is hydrogen or C 1-3 alkyl, R b is hydrogen or C 1-3 alkyl, provided that the total number of carbon atoms in R a and R do not exceed three, R c is C 1-6 alkyl, optionally substituted benzyl or optionally substituted thienylmethyl and R has the meaning ascribed to it in the text.
- R 6 is straight-chain
- the compounds of general formula (1) may be prepared by reacting a compound of the general formula (2), in which the OH group is in the 5- or 6- position of the Het ring system, with a compound of the general formula (3) in the presence of a base in a suitable solvent.
- Typical solvents include NN-dimethyl- formamide, tert-butanol and N-methylpyrrolidin-2-one.
- Suitable bases include potassium carbonate, potassium tert-butoxide, sodium hydride or diwopropylethylamine.
- compounds of the general formula (3) may be prepared by reacting an amine of the general formula (5) with an acid halide of the general formula (4), or the corresponding acid anhydride, in the presence of a suitable inorganic or organic base, such as potassium carbonate or diw ⁇ propylethylamine, in a solvent such as dichloromethane or tetrahydrofuran.
- a suitable inorganic or organic base such as potassium carbonate or diw ⁇ propylethylamine
- amines of the general formula (5) co ⁇ espond to amines of the general formula (9) and may be prepared by alkylation of a silyl-protected aminoalkyne of the general formula (7) using a suitable base, such as n- butyl lithium, followed by reaction with a suitable alkylating reagent R 5 L, such as an alkyl iodide, for example, methyl iodide or 3-chloro-l-iodo-propane, to form an alkylated compound of the general formula (8).
- a suitable base such as n- butyl lithium
- R 5 L such as an alkyl iodide, for example, methyl iodide or 3-chloro-l-iodo-propane
- a silyl-protected aminoalkyne of the general formula (7) may be reacted with a carbonyl derivative R a COR b , for example formaldehyde, using a suitable base, such as n-butyl lithium, to provide an aminoalkyne (8) containing a hydroxyalkyl moiety.
- the silyl protecting group may then be removed from a compound of the general formula (8) with, for example, an aqueous acid to form an aminoalkyne of the general formula (9).
- Aminoalkynes of the general formula (9) may be further derivatised, for instance when R 5 is a hydroxyalkyl group, for example, by reacting a compound of the general formula (9) with a silylating agent, for example t-butyldimethylsilyl chloride, to give a derivative silylated on oxygen of the general formula (9a).
- a compound of the general formula (9) may be treated with a base, such as sodium hydride or potassium b ⁇ (trimethylsilyl)amide followed by a compound R C L to give a compound of the general formula (9b).
- a compound of general formula (8) may be treated with a base, such as sodium or potassium bw(trimethylsilyl)amide, followed by a compound R C L, where L represents a halogen or sulphonate ester such as OSO 2 Me, or OSO 2 -4-tolyl, for example ethyl iodide, to give, after removal of the silyl protecting group, compounds of general formula (9b).
- a base such as sodium or potassium bw(trimethylsilyl)amide
- R C L where L represents a halogen or sulphonate ester such as OSO 2 Me, or OSO 2 -4-tolyl, for example ethyl iodide
- Silyl-protected aminoalkynes of the general formula (7) may be obtained by reacting amines of general formula (6) with l,2-bw-(chlorodimethylsilyl)ethane in the presence of a suitable base, such as a tertiary organic amine base, for example, triethylamine.
- a suitable base such as a tertiary organic amine base, for example, triethylamine.
- Amines of the general formula (6) are either commercially available or may be prepared by standard literature methods (see, for example, EP-A-0834498).
- compounds of the general formula (1) may be prepared by condensing a compound of the general formula (11), wherein Ra is H with an amine of the general formula (5) using suitable activating reagents such as 1-hydroxy- benzotriazole and N-(3-dimethylaminopropyl)-N-ethyl-carbodiimide hydrochloride.
- suitable activating reagents such as 1-hydroxy- benzotriazole and N-(3-dimethylaminopropyl)-N-ethyl-carbodiimide hydrochloride.
- R 2 is other than hydrogen
- the R 2 group may be introduced into an aminoalkyne of the general formula (9) by known techniques to form an amine of the general formula (5).
- esters of the general formula (12) may be prepared by the hydrolysis of the co ⁇ esponding esters of general formula (11), wherein Ra is Cj -4 alkyl, using known techniques.
- the esters of the general formula (11), wherein Ra is C ⁇ _ 4 alkyl and also acids of the general formula (11), wherein Ra is H, may be prepared by reacting a compound of the general formula (2) with an ester or acid of the general formula (10a) in the presence of a suitable base, such as potassium carbonate or sodium hydride, in a suitable solvent, such as NN-dimethylformamide.
- a suitable base such as potassium carbonate or sodium hydride
- suitable solvent such as NN-dimethylformamide.
- the esters or acids of the general formula (10a) are either commercially available or may be prepared by standard literature methods from commercially available materials.
- compounds of the general formula (11) may be prepared under Mitsunobu conditions by reacting a compound of the general formula (2) with a compound of the general formula (10b), wherein Ra is C 1- alkyl, using a phosphine, such as triphenyl phosphine, and an azoester, such as diethyl azodi- carboxylate.
- a phosphine such as triphenyl phosphine
- an azoester such as diethyl azodi- carboxylate.
- compounds of the general formula (1) may be prepared by reacting a compound of general formula (lOd) with a compound of the general formula (2) under Mitsunobu conditions using a phosphine, such as triphenyl phosphine, and an azoester, such as diethyl azodicarboxylate.
- a phosphine such as triphenyl phosphine
- an azoester such as diethyl azodicarboxylate.
- Compounds of general formula (lOd) may be prepared from a compound of general formula (10c) and an amine of general formula (5) using suitable activating reagents such as 1-hydroxybenzotriazole and N-(3-dimethylamino- propyl)-N-ethyl-carbodiimide hydrochloride.
- suitable activating reagents such as 1-hydroxybenzotriazole and N-(3-dimethylamino- propyl)-N-ethyl-carbod
- the compounds of the general formula (1) may be prepared by reacting an acid halide of the general formula (13) with an amine of the general formula (5) in a suitable solvent, such as dichloromethane, in the presence of a tertiary amine, such as triethylamine, and an activating agent, such as 4-dimethylaminopyridine.
- a suitable solvent such as dichloromethane
- an activating agent such as 4-dimethylaminopyridine.
- an acid chloride of the general formula (13) where Hal is Cl may be prepared by chlorinating a compound of the general formula (12) with a suitable chlorinating agent, such as oxalyl chloride, in a suitable solvent, such as dichloromethane, and in the presence of, for example, NN-dimethylformamide.
- a suitable chlorinating agent such as oxalyl chloride
- a suitable solvent such as dichloromethane
- compounds of the general formula (1), wherein R 5 is H may be reacted under Sonogashira conditions with, for example, optionally substituted phenyl or thienyl chlorides, bromides, iodides or triflates to form substituted phenyl or thienyl compounds of general formula (1), wherein R 5 is an optionally substituted phenyl or thienyl group.
- a suitable palladium catalyst is tetrakis(triphenylphosphine)- palladium(O).
- esters of the formula (15) may be halogenated to give haloesters of the general formula (16), by treatment with a suitable halogenating agent, such as N-bromosuccinimide, in a suitable solvent such as carbon tetrachloride or acetonitrile, at between ambient temperature and the reflux temperature of the solvent.
- a suitable halogenating agent such as N-bromosuccinimide
- haloesters of the general formula (16) can be reacted with an alkali metal compound M + OR 6 , where M is suitably sodium or potassium in, for example, an alcohol R 6 OH as solvent, at between 0°C and 40°C, preferably at ambient temperature, to give compounds of the general formula (17).
- haloethers of general formula (18) can be reacted with a compound of the general formula (2), in which the OH group is in the 5- or 6-position of the Het ring system, in the presence of a base such as sodium hydride or potassium t-butoxide, in a suitable solvent, for example THF or DMF, at between 0°C and 60°C, preferably at ambient temperature, to give compounds of the general formula (17).
- the esters (17) can be hydrolysed to acids of the general formula (19), by treatment with an alkali metal hydroxide, such as sodium hydroxide, in an aqueous alcohol R 6 OH, at between ambient temperature and reflux temperature of the solvent.
- a carboxylic acid of the general formula (19) can be condensed with an amine of the general formula (5) to give a compound of the general formula (14), where R 6 is as defined above, using suitable activating reagents such as 1-hydroxybenzotriazole and N-
- esters of the general formula (1) where Ri is a C 3-4 alkenyl group, may be prepared from esters of the general formula (22), wherein R 7 and R 8 are as defined above.
- Esters of the general formula (22) are treated with a strong base, such as lithium bw(trimethylsilyl)amide, at between -78°C and ambient temperature, preferably at -78°C, and then reacted with a trialkylsilyl chloride R 3 SiCl, such as trimethylsilyl chloride, or trialkylsilyl triflate R 3 SiOSO 2 CF 3 , and allowed to warm to ambient temperature.
- a strong base such as lithium bw(trimethylsilyl)amide
- Heterocyclic Chemistry (Eds. in chief A. R. Katritzky, C. W. Rees, E. F. V. Schriven) Elsevier Science Ltd. (1999).
- Het-OH are commercially available, known in the literature or may be made by transformation of known heterocycles.
- the compounds of formula (1) are active fungicides and may be used to control one or more of the following pathogens: Pyriculana oryzae ⁇ Magnaporthe grisea) on rice and wheat and other Pyriculana spp. on other hosts; Puccinia triticina (or recondita), Puccinia st ⁇ iformis and other rusts on wheat, Puccinia hordei, Puccinia striiformis and other rusts on barley, and rusts on other hosts (for example turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants); Erysiphe cichoracearum on cucurbits (for example melon); Blumeria (or Erysiphe) graminis (powdery mildew) on barley, wheat, rye and turf and other powdery mildews on various hosts, such as Sphaerotheca macularis on hops, Spha
- the compounds of formula (I) show particularly good activity against the Oomycete class of pathogens such as Phytophthora infestans, Plasmopara species, e.g. Plasmopara viticola and Pythium species e.g. Pythium ultimum.
- a compound of formula (1) may move acropetally, basipetally or locally in plant tissue to be active against one or more fungi.
- a compound of formula (1) may be volatile enough to be active in the vapour phase against one or more fungi on the plant.
- the invention therefore provides a method of combating or controlling phyto- pathogenic fungi which comprises applying a fungicidally effective amount of a compound of formula (1), or a composition containing a compound of formula (1), to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium, e.g. nutrient solution.
- plant as used herein includes seedlings, bushes and trees. Furthermore, the fungicidal method of the invention includes protectant, curative, systemic, eradicant and antisporulant treatments.
- the compounds of formula (1) are preferably used for agricultural, horticultural and turfgrass purposes in the form of a composition.
- a compound of formula (1) is usually formulated into a composition which includes, in addition to the compound of formula (1), a suitable inert diluent or ca ⁇ ier and, optionally, a surface active agent (SFA).
- SFAs are chemicals which are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting).
- compositions both solid and liquid formulations
- the composition is generally used for the control of fungi such that a compound of formula (1) is applied at a rate of from 0. lg to 10kg per hectare, preferably from lg to 6kg per hectare, more preferably from lg to 1kg per hectare.
- a compound of formula (1) When used in a seed dressing, a compound of formula (1) is used at a rate of O.OOOlg to lOg (for example O.OOlg or 0.05g), preferably 0.005g to lOg, more preferably 0.005g to 4g, per kilogram of seed.
- the present invention provides a fungicidal composition
- a fungicidal composition comprising a fungicidally effective amount of a compound of formula (1) and a suitable carrier or diluent therefor.
- the invention provides a method of combating and controlling fungi at a locus, which comprises treating the fungi, or the locus of the fungi with a fungicidally effective amount of a composition comprising a compound of formula (1).
- compositions can be chosen from a number of formulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations.
- the formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of formula (1).
- Dustable powders may be prepared by mixing a compound of formula (1) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid ca ⁇ iers) and mechanically grinding the mixture to a fine powder.
- solid diluents for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid ca ⁇ iers
- Soluble powders may be prepared by mixing a compound of formula (1) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water soluble granules (SG).
- water-soluble inorganic salts such as sodium bicarbonate, sodium carbonate or magnesium sulphate
- water-soluble organic solids such as a polysaccharide
- wetting agents such as sodium bicarbonate, sodium carbonate or magnesium sulphate
- dispersing agents such as sodium bicarbonate, sodium carbonate or magnesium sulphate
- SG water soluble granules
- WP Wettable powders
- WG Water dispersible granules
- Granules may be formed either by granulating a mixture of a compound of formula (1) and one or more powdered solid diluents or carriers, or from pre-formed blank granules by absorbing a compound of formula (1) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of formula (1) (or a solution thereof, in a suitable agent) on to a hard core material, (such as sands, silicates, mineral carbonates, sulphates or phosphates) and drying if necessary.
- a hard core material such as sands, silicates, mineral carbonates, sulphates or phosphates
- Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils).
- solvents such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters
- sticking agents such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils.
- One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent).
- DC Dispersible Concentrates
- DC may be prepared by dissolving a compound of formula (1) in water or an organic solvent, such as a ketone, alcohol or glycol ether. These solutions may contain a surface active agent (for example to improve water dilution or prevent crystallisation in a spray tank).
- Emulsifiable concentrates or oil-in-water emulsions (EW) may be prepared by dissolving a compound of formula (1) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents).
- Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclohexanone), alcohols (such as benzyl alcohol, furfuryl alcohol or butanol), N-alkylpy ⁇ olidones (such as N-methylpy ⁇ olidone or N- octylpyrrolidone), dimethyl amides of fatty acids (such as C 8 -Cio fatty acid dimethylamide) and chlorinated hydrocarbons.
- aromatic hydrocarbons such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark
- ketones such
- An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment.
- Preparation of an EW involves obtaining a compound of formula (1) either as a liquid (if it is not a liquid at room temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion.
- Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents which have a low solubility in water.
- Microemulsions may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a thermodynamically stable isotropic liquid formulation.
- a compound of formula (1) is present initially in either the water or the solvent/SFA blend.
- Suitable solvents for use in MEs include those hereinbefore described for use in in ECs or in EWs.
- An ME may be either an oil-in-water or a water-in-oil system (which system is present may be determined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same formulation.
- An ME is suitable for dilution into water, either remaining as a microemulsion or forming a conventional oil-in-water emulsion.
- SC Suspension concentrates
- SCs may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of formula (1).
- SCs may be prepared by ball or bead milling the solid compound of formula (1) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound.
- One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle.
- a compound of formula (1) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product.
- Aerosol formulations comprise a compound of formula (1) and a suitable propellant (for example n-butane).
- a compound of formula (1) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as n- propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps.
- a suitable medium for example water or a water miscible liquid, such as n- propanol
- a compound of formula (1) may be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating, in an enclosed space, a smoke containing the compound.
- Capsule suspensions may be prepared in a manner similar to the preparation of EW formulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of formula (1) and, optionally, a carrier or diluent therefor.
- the polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure.
- the compositions may provide for controlled release of the compound of formula (1) and they may be used for seed treatment.
- a compound of formula (1) may also be formulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound.
- a composition may include one or more additives to improve the biological performance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of formula (1)).
- additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of formula (1)).
- a compound of formula (1) may also be formulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS).
- DS powder for dry seed treatment
- SS water soluble powder
- WS water dispersible powder for slurry treatment
- CS capsule suspension
- the preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectively, DP, SP, WP, SC and DC compositions described above.
- Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-forming barrier).
- Wetting agents, dispersing agents and emulsifying agents may be SFAs of the cationic, anionic, amphoteric or non-ionic type.
- Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts.
- Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecyl- benzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di-z ' scpropyl- and tri-w ⁇ propyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3- carboxylate), phosphate esters (products from the reaction between one or more fatty alcohols
- Suitable SFAs of the amphoteric type include betaines, propionates and glycinates.
- Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins.
- Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite).
- a compound of formula (1) may be applied by any of the known means of applying fungicidal compounds. For example, it may be applied, formulated or unformulated, to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil su ⁇ ounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste formulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water-soluble bag) in soil or an aqueous environment.
- a composition such as a granular composition or a composition packed in a water-soluble bag
- a compound of formula (1) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems.
- Compositions for use as aqueous preparations are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use.
- These concentrates which may include DCs, SCs, ECs, EWs, MEs SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment.
- Such aqueous preparations may contain varying amounts of a compound of formula (1) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used.
- a compound of formula (1) may be used in mixtures with fertilisers (for example nitrogen-, potassium- or phosphorus-containing fertilisers).
- fertilisers for example nitrogen-, potassium- or phosphorus-containing fertilisers.
- Suitable formulation types include granules of fertiliser.
- the mixtures suitably contain up to 25% by weight of the compound of formula (1).
- the invention therefore also provides a fertiliser composition
- a fertiliser composition comprising a fertiliser and a compound of formula (1).
- the compositions of this invention may contain other compounds having biological activity, for example micronutrients or compounds having similar or complementary fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.
- the resulting composition may have a broader spectrum of activity or a greater level of intrinsic activity than the compound of formula (1) alone. Further the other fungicide may have a synergistic effect on the fungicidal activity of the compound of formula (1).
- the compound of formula (1) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator where appropriate.
- An additional active ingredient may: provide a composition having a broader spectrum of activity or increased persistence at a locus; synergise the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of formula (1); or help to overcome or prevent the development of resistance to individual components.
- the particular additional active ingredient will depend upon the intended utility of the composition.
- fungicidal compounds which may be included in the composition of the invention are AC 382042 (N-(l -cyano- l,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) propionamide), acibenzolar-S-methyl, alanycarb, aldimorph, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, benthiavalicarb, biloxazol, bitertanol, blasticidin S, boscalid (new name for nicobifen), bromuconazole, bupirimate, captafol, captan; carbendazim, carbendazim chlorhydrate, carboxin, carpropamid, carvone, CGA 41396, CGA 41397, chinomethionate, chlorbenzthiazone, chlorothalonil, chlorozolinate, clozylacon, copper containing compounds such
- the compounds of formula (1) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases.
- Some mixtures may comprise active ingredients which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional formulation type.
- other formulation types may be prepared.
- one active ingredient is a water insoluble solid and the other a water insoluble liquid
- SE suspoemulsion
- bs broad singlet
- Step 2 The product from Step 1 (13.0g) in dry tetrahydrofuran (140ml) was cooled to -
- Step 4 The preparation of 2-bromo-N-(4-methylpent-2-yn-4-yl) butyramide
- the product from Step 3 (5.0g) was dissolved in dry dichloromethane (200ml), cooled to 3°C with sti ⁇ ing then 2-bromobutyryl bromide (6.25g) was added followed by dropwise addition of dry triethylamine (10.93ml), maintaining the reaction at 5°C.
- 2-Amino-6-methoxybenzothiazole (9.0g, commercially available) in dry NN-dimethyl- formamide (10ml) was added dropwise over 35tninutes to a stirred solution of tert-butyl nitrite (9.9ml) in N,N-dimethylformamide (40ml) at 65°C. The temperature of the mixture was kept higher than 73°C during the addition. On complete addition of the solution of the benzothiazole, the dark red solution was stirred for an additional 15 minutes, cooled to ambient temperature then poured into dilute hydrochloric acid (200ml) and diluted with brine.
- 6-Methoxybenzothiazole (1.2g) in hydrobromic acid (10ml, 48%) was heated at 120°C with stirring for 6 hours then stored at ambient temperature for 2 days. The hot, pale yellow solution produced a suspension on cooling. The suspension was dissolved by the addition of water then the solution was adjusted to pH 6 by addition of sodium hydrogen carbonate and the solid which precipitated was filtered from solution, washed with water and sucked to dryness. The solid was dissolved in ethyl acetate, dried over magnesium sulphate and evaporated under reduced pressure to give 6-hydroxybenzothiazole, 1.05g, as a colourless solid.
- 6-methoxy-2-methylbenzothiazole (commercially available) was converted to 6-hydroxy-2-methylbenzothiazole, colourless solid.
- Stage 3 6-Hydroxybenzothiazole (0.151g) and 2-bromo-N-(4-methylpent-2-yn-4-yl) butyramide (0.246g) were stirred in dry NN-dimethylformamide (2ml) containing anhydrous potassium carbonate (0.207g) and heated to 90°C for 6 hours.
- the mixture was cooled to ambient temperature, stored for 18 hours then taken to pH 7 with dilute hydrochloric acid.
- the suspension was diluted with water, extracted with diethyl ether and the extract was washed with water, aqueous sodium hydroxide then water and dried over magnesium sulphate.
- the dried extract was absorbed onto silica gel and this added to a column of silica gel and then fractionated by chromatography (silica; hexane / ethyl acetate, 1 : 1 by volume) to give the required product, 0.306g, as a colourless gum.
- Stage 1 The preparation of 2-bromo-3-methoxy-N-(4-methylpent-2-yn-4-yl)- propionamide Step 1: Preparation of methyl 2-bromo-3-methoxypropionate
- Methyl 2,3-dibromopropionate (21.9g) and trimethylamine N-oxide (O.lg) in methanol (8ml) were cooled to -5°C with stirring under an atmosphere of nitrogen.
- a methanolic solution of sodium methoxide, freshly prepared from sodium (2.25g) and methanol (24ml) was added dropwise over 15 minutes to the mixture, which was maintained below 0°C by cooling. On completion of addition, the mixture was stirred for a further 30 minutes and acetic acid (1ml) was added followed by diethyl ether (100ml).
- Step 2 Preparation of 2-bromo-3-methoxypropionic acid.
- Methyl 2-bromo-3-methoxypropionate (l.OOg) in tetrahydrofuran (8ml) was sti ⁇ ed at 10°C and lithium hydroxide monohydrate (0.21g) in water (1.5ml) was added dropwise. On complete addition, the mixture was sti ⁇ ed for 1.5 hours.
- the colourless solution was evaporated under reduced pressure to a small volume and the aqueous solution was taken to pH 3 with dilute sulphuric acid.
- the mixture was extracted with diethyl ether (50ml) and the organic phase separated, washed with brine, dried over magnesium sulphate then evaporated under reduced pressure to give the required product (0.6g) as a colourless liquid.
- Step 3 Preparation of 2-bromo-N-(4-methylpent-2-yn-4-yl 3-methoxypropionamide.
- 2-Bromo-3-methoxypropionic acid (0.366g) was dissolved in dry dichloro- methane (4ml) containing dry NN-dimethylformamide (0.05ml) with sti ⁇ ing and oxalyl chloride (0.254g) ' was added.
- 6-Hydroxybenzothiazole (0.151g) and 2-bromo-3-methoxy-N-(4-methylpent-2-yn-4-yl) propionamide (0.262g) were stirred in dry NN-dimethylformamide (2ml) containing anhydrous potassium carbonate (0.207 g) and heated to 90°C for 5 hours. The mixture was cooled to ambient temperature, stored for 18 hours then taken to pH 7 with dilute hydrochloric acid. The suspension was diluted with water, extracted with diethyl ether and the extract was washed with water, aqueous sodium hydroxide then water and dried over magnesium sulphate.
- 6-Hydroxybenzoxazole (0.29g) and 2-bromo-N-(4-methylpent-2-yn-4-yl) butyramide (0.517g) were sti ⁇ ed in dry NN-dimethylformamide (5ml) containing anhydrous potassium carbonate (0.414g) and heated to 80°C for 6 hours. The mixture was cooled to ambient temperature, stored for 18 hours then diluted with aqueous sodium hydroxide (2M). The emulsion produced was extracted with diethyl ether and the organic extract was washed with water, dried over magnesium sulphate then evaporated under reduced pressure to give a pale brown gum.
- the gum was absorbed onto silica gel, added to a column of silica gel and fractionated by chromatography (silica; hexane / ethyl acetate) to give a pink gum that solidified on triturating with a small volume of hexane/ diethyl ether to give the required product as a solid, 0.416g, m.p. 95-97 °C.
- EXAMPLE 4 This Example illustrates the fungicidal properties of compounds of formula (1).
- the compounds were tested in a leaf disk assay, with methods described below.
- the test compounds were dissolved in DMSO and diluted into water to 200 ppm, 60 ppm and 20 ppm.
- Erysiphe graminis f.sp. hordei barley powdery mildew: Barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus.
- Erysiphe graminis f.sp. tritici wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
- tritici wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity.
- Septo ⁇ a nodorum wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus.
- Pyrenophora teres barley net blotch: Barley leaf segments were placed on agar in a 24- well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
- Pyriculana oryzae rice blast
- the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
- Botrytis cinerea grey mould: Bean leaf disks were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
- Phytophthora infestans (late blight of potato on tomato): Tomato leaf disks were placed on water agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity.
- Plasmopara viticola downy mildew of grapevine: Grapevine leaf disks were placed on agar in a 24-well plate and sprayed a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed seven days after inoculation as preventive fungicidal activity.
- Pythium ultimum (Damping off): Mycelial fragments of the fungus, prepared from a fresh liquid culture, were mixed into potato dextrose broth. A solution of the test compound in dimethyl sulphoxide was diluted with water to 20 ppm then placed into a 96-well microtiter plate and the nutrient broth containing the fungal spores was added. The test plate was incubated at 24°C and the inhibition of growth was determined photometrically after 48 hours.
- Plasmopara viticola 2(1), 2(11), 2(61).
- the following Compounds gave at least 60% control of the following fungal infection at 20ppm: Pythium ultimum: 2(1), 2(39).
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- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
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CA002525093A CA2525093A1 (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides |
DE602004025236T DE602004025236D1 (en) | 2003-06-04 | 2004-05-28 | N-ALKYNYL-2-HETEROARYLOXYALKYLAMIDE FOR USE AS FUNGICIDES |
PL04735275T PL1633730T3 (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides |
BRPI0411040-4A BRPI0411040A (en) | 2003-06-04 | 2004-05-28 | n-alkynyl-2-heteroaryloxyalkylamides for use as fungicides |
MXPA05013034A MXPA05013034A (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides. |
JP2006508379A JP2006526601A (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides as fungicides |
US10/558,331 US20070197472A1 (en) | 2003-06-04 | 2004-05-28 | N-Alkynyl-2-Heteroaryloxyalkylamides For Use As Fungicides |
EP04735275A EP1633730B1 (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides |
AT04735275T ATE455770T1 (en) | 2003-06-04 | 2004-05-28 | N-ALKYNYL-2-HETEROARYLOXYALKYLAMIDE FOR USE AS FUNGICIDES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB0312864.2A GB0312864D0 (en) | 2003-06-04 | 2003-06-04 | Fungicides |
GB0312864.2 | 2003-06-04 |
Publications (1)
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WO2004108694A1 true WO2004108694A1 (en) | 2004-12-16 |
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ID=9959328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/GB2004/002308 WO2004108694A1 (en) | 2003-06-04 | 2004-05-28 | N-alkynyl-2-heteroaryloxyalkylamides for use as fungicides |
Country Status (15)
Country | Link |
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US (1) | US20070197472A1 (en) |
EP (1) | EP1633730B1 (en) |
JP (1) | JP2006526601A (en) |
KR (1) | KR20060006977A (en) |
CN (1) | CN100396672C (en) |
AR (1) | AR044545A1 (en) |
AT (1) | ATE455770T1 (en) |
BR (1) | BRPI0411040A (en) |
CA (1) | CA2525093A1 (en) |
DE (1) | DE602004025236D1 (en) |
ES (1) | ES2338423T3 (en) |
GB (1) | GB0312864D0 (en) |
MX (1) | MXPA05013034A (en) |
PL (1) | PL1633730T3 (en) |
WO (1) | WO2004108694A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7271130B2 (en) | 2002-11-26 | 2007-09-18 | Syngenta Limited | N-alkynyl-2-(substituted phenoxy) alkylamides and their use as fungicides |
US7371764B2 (en) | 2002-11-26 | 2008-05-13 | Syngenta Limited | Quinolin-isoquinolin-and quinazolin-oxyalkylamides and their use as fungicides |
US7420090B2 (en) | 2002-11-26 | 2008-09-02 | Syngenta Limited | Fungicides |
US7511151B2 (en) | 2002-11-26 | 2009-03-31 | Syngenta Limited | Substituted pyridyloxyalkylamides and their use as fungicides |
US8067592B2 (en) | 2003-06-04 | 2011-11-29 | Syngenta Limited | N-alkyny-2-(substituted aryloxy) alkylthioamine derivatives as fungicides |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0426372D0 (en) * | 2004-12-01 | 2005-01-05 | Syngenta Ltd | Fungicides |
GB0426373D0 (en) * | 2004-12-01 | 2005-01-05 | Syngenta Ltd | Fungicides |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784682A (en) * | 1984-05-16 | 1988-11-15 | Bayer Aktiengesellschaft | 6-chlorobenzazolyloxyacetamides |
JP2001089453A (en) * | 1999-09-21 | 2001-04-03 | Kumiai Chem Ind Co Ltd | Heteroaryloxy(thio)alkanoic acid amide derivative and germicide for agriculture and horticulture |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272844A (en) * | 1965-06-03 | 1966-09-13 | Lilly Co Eli | Novel acetylenic amides |
CS189773B2 (en) * | 1975-06-30 | 1979-04-30 | Stauffer Chemical Co | Acaricide means |
US4062977A (en) * | 1975-06-30 | 1977-12-13 | Stauffer Chemical Company | Substituted-N-(1,1-disubstituted ethyl)-α-(substituted phenoxy)-α-alkoxyacetamides and their use as miticides |
US4049423A (en) * | 1975-06-30 | 1977-09-20 | Stauffer Chemical Company | N-dimethylpropynyl-α-methoxy-α-(3,5-dimethylphenoxy)acetamide herbicide |
IN146297B (en) * | 1976-07-30 | 1979-04-14 | Stauffer Chemical Co | |
US4154849A (en) * | 1977-10-26 | 1979-05-15 | Stauffer Chemical Company | N-Cyano-2-(substituted phenoxy) butyramides and their use as mildewicides |
US4168319A (en) * | 1977-10-26 | 1979-09-18 | Stauffer Chemical Company | N-alkynyl-2-(substituted phenoxy) butyramides and their use as mildewicides |
US4146387A (en) * | 1977-11-25 | 1979-03-27 | Stauffer Chemical Company | Synergistic herbicidal compositions |
EP0005501B1 (en) * | 1978-05-20 | 1981-11-25 | Bayer Ag | Heteroaryloxy-acetamides, process for their preparation and their use as herbicides |
BR9712471A (en) * | 1996-10-31 | 1999-10-26 | Kumiai Chemical Industry Co | Pyrimidinyloxycancanamide and fungicide derivatives and agricultural and horticultural fungicides |
NZ500438A (en) * | 1997-07-14 | 2001-11-30 | Adolor Corp | Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness) |
JPH11263776A (en) * | 1997-12-24 | 1999-09-28 | Kumiai Chem Ind Co Ltd | Pyridyloxy(thio)alkanoic acid amide derivative and agricultural/horticultural germicide |
GB0129267D0 (en) * | 2001-12-06 | 2002-01-23 | Syngenta Ltd | Fungicides |
GB0227556D0 (en) * | 2002-11-26 | 2002-12-31 | Syngenta Ltd | Fungicides |
GB0227555D0 (en) * | 2002-11-26 | 2002-12-31 | Syngenta Ltd | Fungicides |
GB0227554D0 (en) * | 2002-11-26 | 2002-12-31 | Syngenta Ltd | Fungicides |
GB0227558D0 (en) * | 2002-11-26 | 2002-12-31 | Syngenta Ltd | Fungicides |
GB0302308D0 (en) * | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
-
2003
- 2003-06-04 GB GBGB0312864.2A patent/GB0312864D0/en not_active Ceased
-
2004
- 2004-05-20 AR ARP040101752A patent/AR044545A1/en unknown
- 2004-05-28 AT AT04735275T patent/ATE455770T1/en not_active IP Right Cessation
- 2004-05-28 JP JP2006508379A patent/JP2006526601A/en active Pending
- 2004-05-28 ES ES04735275T patent/ES2338423T3/en not_active Expired - Lifetime
- 2004-05-28 WO PCT/GB2004/002308 patent/WO2004108694A1/en active Application Filing
- 2004-05-28 DE DE602004025236T patent/DE602004025236D1/en not_active Expired - Lifetime
- 2004-05-28 BR BRPI0411040-4A patent/BRPI0411040A/en not_active IP Right Cessation
- 2004-05-28 EP EP04735275A patent/EP1633730B1/en not_active Expired - Lifetime
- 2004-05-28 CA CA002525093A patent/CA2525093A1/en not_active Abandoned
- 2004-05-28 KR KR1020057023189A patent/KR20060006977A/en not_active Application Discontinuation
- 2004-05-28 PL PL04735275T patent/PL1633730T3/en unknown
- 2004-05-28 CN CNB2004800152827A patent/CN100396672C/en not_active Expired - Fee Related
- 2004-05-28 US US10/558,331 patent/US20070197472A1/en not_active Abandoned
- 2004-05-28 MX MXPA05013034A patent/MXPA05013034A/en active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784682A (en) * | 1984-05-16 | 1988-11-15 | Bayer Aktiengesellschaft | 6-chlorobenzazolyloxyacetamides |
JP2001089453A (en) * | 1999-09-21 | 2001-04-03 | Kumiai Chem Ind Co Ltd | Heteroaryloxy(thio)alkanoic acid amide derivative and germicide for agriculture and horticulture |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 21 3 August 2001 (2001-08-03) * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7271130B2 (en) | 2002-11-26 | 2007-09-18 | Syngenta Limited | N-alkynyl-2-(substituted phenoxy) alkylamides and their use as fungicides |
US7371764B2 (en) | 2002-11-26 | 2008-05-13 | Syngenta Limited | Quinolin-isoquinolin-and quinazolin-oxyalkylamides and their use as fungicides |
US7420090B2 (en) | 2002-11-26 | 2008-09-02 | Syngenta Limited | Fungicides |
US7511151B2 (en) | 2002-11-26 | 2009-03-31 | Syngenta Limited | Substituted pyridyloxyalkylamides and their use as fungicides |
US8067592B2 (en) | 2003-06-04 | 2011-11-29 | Syngenta Limited | N-alkyny-2-(substituted aryloxy) alkylthioamine derivatives as fungicides |
Also Published As
Publication number | Publication date |
---|---|
CA2525093A1 (en) | 2004-12-16 |
GB0312864D0 (en) | 2003-07-09 |
EP1633730A1 (en) | 2006-03-15 |
BRPI0411040A (en) | 2006-07-11 |
DE602004025236D1 (en) | 2010-03-11 |
AR044545A1 (en) | 2005-09-21 |
MXPA05013034A (en) | 2006-03-02 |
KR20060006977A (en) | 2006-01-20 |
ATE455770T1 (en) | 2010-02-15 |
ES2338423T3 (en) | 2010-05-07 |
US20070197472A1 (en) | 2007-08-23 |
CN1798743A (en) | 2006-07-05 |
CN100396672C (en) | 2008-06-25 |
PL1633730T3 (en) | 2010-06-30 |
JP2006526601A (en) | 2006-11-24 |
EP1633730B1 (en) | 2010-01-20 |
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