WO2004106322A2 - Polymorphs of aripiprazole - Google Patents
Polymorphs of aripiprazole Download PDFInfo
- Publication number
- WO2004106322A2 WO2004106322A2 PCT/IN2004/000113 IN2004000113W WO2004106322A2 WO 2004106322 A2 WO2004106322 A2 WO 2004106322A2 IN 2004000113 W IN2004000113 W IN 2004000113W WO 2004106322 A2 WO2004106322 A2 WO 2004106322A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aripiprazole
- polymorph
- novel
- ray diffraction
- dsc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04770647A EP1618103A2 (en) | 2003-04-25 | 2004-04-22 | Polymorphs of aripiprazole |
US10/554,366 US20060270683A1 (en) | 2003-04-25 | 2004-04-22 | Polymorphs of aripiprazole |
NO20054762A NO20054762L (en) | 2003-04-25 | 2005-10-17 | Polymorphs of aripiprazole |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN412MU2003 | 2003-04-25 | ||
IN412/MUM/2003 | 2003-04-25 | ||
IN583/MUM/2003 | 2003-06-06 | ||
IN583MU2003 | 2003-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004106322A2 true WO2004106322A2 (en) | 2004-12-09 |
WO2004106322A3 WO2004106322A3 (en) | 2005-04-21 |
Family
ID=33492303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2004/000113 WO2004106322A2 (en) | 2003-04-25 | 2004-04-22 | Polymorphs of aripiprazole |
Country Status (4)
Country | Link |
---|---|
US (1) | US20060270683A1 (en) |
EP (1) | EP1618103A2 (en) |
NO (1) | NO20054762L (en) |
WO (1) | WO2004106322A2 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005058835A3 (en) * | 2003-12-16 | 2005-08-11 | Teva Pharma | Methods of preparing aripiprazole crystalline forms |
WO2006053781A1 (en) * | 2004-11-18 | 2006-05-26 | Synthon B.V. | Process of making crystalline aripiprazole |
EP1686126A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Salts of aripiprazole |
WO2006079549A1 (en) | 2005-01-27 | 2006-08-03 | Sandoz Ag | Salts of aripiprazole |
WO2006097343A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Process of making crystalline type ii aripiprazole |
WO2006097344A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
WO2007004061A1 (en) * | 2005-04-15 | 2007-01-11 | Medichem, S.A. | Syntheses and preparations of polymorphs of crystalline aripiprazole |
WO2007007132A1 (en) * | 2005-07-14 | 2007-01-18 | EGIS GYOGYSZERGYAR Nyilvánosan Működő Részvénytársaság | Aripiprazole salts |
WO2007075871A2 (en) * | 2005-12-22 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Processes for reducing particle size of aripiprazole |
WO2008020453A2 (en) * | 2006-08-17 | 2008-02-21 | Unichem Laboratories Limited | A process for the preparation of a novel crystalline polymorph of aripiprazole |
US7361756B2 (en) | 2004-02-05 | 2008-04-22 | Teva Pharmaceutical Industries Ltd. | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
EP2082735A1 (en) | 2008-01-23 | 2009-07-29 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
US7714129B2 (en) | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
US7825125B2 (en) | 2006-07-20 | 2010-11-02 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE429906T1 (en) * | 2006-01-05 | 2009-05-15 | Teva Pharma | DRY ARIPIPRAZOLE FORMULATIONS |
ES2318693T5 (en) * | 2006-01-05 | 2018-10-04 | Teva Pharmaceutical Industries Ltd | Wet granulation process for the preparation of pharmaceutical compositions of aripiprazole |
EP2238976B1 (en) | 2009-04-03 | 2012-06-27 | Hexal AG | Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof |
WO2012003418A2 (en) * | 2010-07-02 | 2012-01-05 | The University Of North Carolina At Chapel Hill | Functionally selective ligands of dopamine d2 receptors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003026659A1 (en) * | 2001-09-25 | 2003-04-03 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
-
2004
- 2004-04-22 WO PCT/IN2004/000113 patent/WO2004106322A2/en active Application Filing
- 2004-04-22 EP EP04770647A patent/EP1618103A2/en not_active Withdrawn
- 2004-04-22 US US10/554,366 patent/US20060270683A1/en not_active Abandoned
-
2005
- 2005-10-17 NO NO20054762A patent/NO20054762L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003026659A1 (en) * | 2001-09-25 | 2003-04-03 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005058835A3 (en) * | 2003-12-16 | 2005-08-11 | Teva Pharma | Methods of preparing aripiprazole crystalline forms |
US7504504B2 (en) | 2003-12-16 | 2009-03-17 | Teva Pharmaceutical Industries Ltd. | Methods of preparing aripiprazole crystalline forms |
US7714129B2 (en) | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
JP2007517783A (en) * | 2003-12-16 | 2007-07-05 | テバ ファーマシューティカル インダストリーズ リミティド | Method for preparing aripiprazole crystalline form |
US7361756B2 (en) | 2004-02-05 | 2008-04-22 | Teva Pharmaceutical Industries Ltd. | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
WO2006053781A1 (en) * | 2004-11-18 | 2006-05-26 | Synthon B.V. | Process of making crystalline aripiprazole |
WO2006079549A1 (en) | 2005-01-27 | 2006-08-03 | Sandoz Ag | Salts of aripiprazole |
AU2010241386B9 (en) * | 2005-01-27 | 2013-07-25 | Sandoz Ag | Salts of aripiprazole |
AU2010241386B2 (en) * | 2005-01-27 | 2013-07-11 | Sandoz Ag | Salts of aripiprazole |
CN101107242B (en) * | 2005-01-27 | 2011-08-10 | 桑多斯股份公司 | Salts of aripiprazole |
EP1686126A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Salts of aripiprazole |
JP2008536798A (en) * | 2005-01-27 | 2008-09-11 | サンド・アクチエンゲゼルシヤフト | Salt of aripiprazole |
US7884205B2 (en) | 2005-01-27 | 2011-02-08 | Sandoz Ag | Salts of aripiprazole |
WO2006097344A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
WO2006097343A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Process of making crystalline type ii aripiprazole |
EP2783688A1 (en) * | 2005-03-17 | 2014-10-01 | Synhton B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
WO2007004061A1 (en) * | 2005-04-15 | 2007-01-11 | Medichem, S.A. | Syntheses and preparations of polymorphs of crystalline aripiprazole |
JP2009501204A (en) * | 2005-07-14 | 2009-01-15 | エギシュ ヂョヂセルヂャール ニルヴァーノサン ミケデ レースヴェーニタールササーグ | Aripiprazole salt |
WO2007007132A1 (en) * | 2005-07-14 | 2007-01-18 | EGIS GYOGYSZERGYAR Nyilvánosan Működő Részvénytársaság | Aripiprazole salts |
WO2007075871A3 (en) * | 2005-12-22 | 2008-04-03 | Teva Pharma | Processes for reducing particle size of aripiprazole |
WO2007075871A2 (en) * | 2005-12-22 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Processes for reducing particle size of aripiprazole |
US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
US7825125B2 (en) | 2006-07-20 | 2010-11-02 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
WO2008020453A3 (en) * | 2006-08-17 | 2009-05-28 | Unichem Lab Ltd | A process for the preparation of a novel crystalline polymorph of aripiprazole |
WO2008020453A2 (en) * | 2006-08-17 | 2008-02-21 | Unichem Laboratories Limited | A process for the preparation of a novel crystalline polymorph of aripiprazole |
EP2082735A1 (en) | 2008-01-23 | 2009-07-29 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
Also Published As
Publication number | Publication date |
---|---|
NO20054762L (en) | 2006-01-24 |
NO20054762D0 (en) | 2005-10-17 |
US20060270683A1 (en) | 2006-11-30 |
EP1618103A2 (en) | 2006-01-25 |
WO2004106322A3 (en) | 2005-04-21 |
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