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WO2004096176A3 - Solid drug formulation and device for storage and controlled delivery thereof - Google Patents

Solid drug formulation and device for storage and controlled delivery thereof

Info

Publication number
WO2004096176A3
WO2004096176A3 PCT/US2004/012757 US2004012757W WO2004096176A3 WO 2004096176 A3 WO2004096176 A3 WO 2004096176A3 US 2004012757 W US2004012757 W US 2004012757W WO 2004096176 A3 WO2004096176 A3 WO 2004096176A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
drug
solid
reservoirs
controlled
matrix
Prior art date
Application number
PCT/US2004/012757
Other languages
French (fr)
Other versions
WO2004096176A2 (en )
Inventor
James H Prescott
John T Santini Jr
Mark A Staples
Scott A Uhland
Original Assignee
Microchips Inc
James H Prescott
John T Santini Jr
Mark A Staples
Scott A Uhland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

Devices and methods are provided for the storage and controlled release of a solid form of a drug. The device comprises a body portion; one or more reservoirs located in and defined by the body portion; a solid matrix which comprises a drug and which is contained in each of the one or more reservoirs; and one or more excipient materials dispersed throughout pores or interstices within the solid matrix and substantially filling any space not otherwise occupied by the solid matrix within each of the one or more reservoirs, wherein the excipient material enhances stability of the drug while stored in the one or more reservoirs or enhances release of the drug from each reservoir. In an alternative embodiment, the device provides for the storage and controlled exposure of a chemical sensor material.
PCT/US2004/012757 2003-04-25 2004-04-26 Solid drug formulation and device for storage and controlled delivery thereof WO2004096176A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US46546603 true 2003-04-25 2003-04-25
US60/465,466 2003-04-25

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA 2523432 CA2523432C (en) 2003-04-25 2004-04-26 Solid drug formulation and device for storage and controlled delivery thereof
EP20040750642 EP1638522B1 (en) 2003-04-25 2004-04-26 Solid drug formulation and device for storage and controlled delivery thereof
DE200460031011 DE602004031011D1 (en) 2003-04-25 2004-04-26 Solid pharmaceutical formulation and device for its retention and controlled delivery
JP2006513311A JP4734236B2 (en) 2003-04-25 2004-04-26 Device and a manufacturing method thereof for storage of the solid form of the drug and controlled release

Publications (2)

Publication Number Publication Date
WO2004096176A2 true WO2004096176A2 (en) 2004-11-11
WO2004096176A3 true true WO2004096176A3 (en) 2005-03-24

Family

ID=33418242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012757 WO2004096176A3 (en) 2003-04-25 2004-04-26 Solid drug formulation and device for storage and controlled delivery thereof

Country Status (7)

Country Link
US (2) US20040247671A1 (en)
EP (1) EP1638522B1 (en)
JP (1) JP4734236B2 (en)
CA (1) CA2523432C (en)
DE (1) DE602004031011D1 (en)
ES (1) ES2359243T3 (en)
WO (1) WO2004096176A3 (en)

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US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface

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DE602004031011D1 (en) * 2003-04-25 2011-02-24 Boston Scient Scimed Inc Solid pharmaceutical formulation and device for its retention and controlled delivery
US8095197B2 (en) 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
US7577470B2 (en) 2003-11-13 2009-08-18 Medtronic Minimed, Inc. Long term analyte sensor array
US8414489B2 (en) * 2003-11-13 2013-04-09 Medtronic Minimed, Inc. Fabrication of multi-sensor arrays
EP1765455A2 (en) * 2004-06-01 2007-03-28 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20060067972A1 (en) * 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
JP5107041B2 (en) 2004-09-01 2012-12-26 マイクロチップス・インコーポレーテッド For the controlled release or exposure of reservoir contents, the multi-cap reservoir bus device
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US7413846B2 (en) 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
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US20070112421A1 (en) * 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
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US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
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EP2959925A1 (en) 2006-09-15 2015-12-30 Boston Scientific Limited Medical devices and methods of making the same
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US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
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US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
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US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
JP5599393B2 (en) 2008-07-07 2014-10-01 コーニンクレッカ フィリップス エヌ ヴェ Electronic pill having a drug reservoir
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8236238B2 (en) * 2009-01-21 2012-08-07 Palo Alto Research Center Incorporated Drug deactivation system
US9480795B2 (en) * 2009-01-21 2016-11-01 Palo Alto Research Center Incorporated Sensor system for drug delivery device, drug delivery device having the same and method of using the same
US7838715B2 (en) * 2009-01-21 2010-11-23 Palo Alto Research Center Incorporated Drug deactivation system and method of deactivating a drug using the same
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
CN103906466B (en) * 2011-08-25 2017-02-22 微芯片生物科技公司 Closure apparatus and method for manufacturing a space-saving
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers

Also Published As

Publication number Publication date Type
EP1638522A2 (en) 2006-03-29 application
US20040247671A1 (en) 2004-12-09 application
JP2006524705A (en) 2006-11-02 application
WO2004096176A2 (en) 2004-11-11 application
EP1638522B1 (en) 2011-01-12 grant
US20100119604A1 (en) 2010-05-13 application
ES2359243T3 (en) 2011-05-19 grant
JP4734236B2 (en) 2011-07-27 grant
DE602004031011D1 (en) 2011-02-24 grant
CA2523432C (en) 2014-10-28 grant
CA2523432A1 (en) 2004-11-11 application

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