WO2004089353A3 - Methods for treatment of parkinson's disease - Google Patents

Methods for treatment of parkinson's disease Download PDF

Info

Publication number
WO2004089353A3
WO2004089353A3 PCT/IB2004/001408 IB2004001408W WO2004089353A3 WO 2004089353 A3 WO2004089353 A3 WO 2004089353A3 IB 2004001408 W IB2004001408 W IB 2004001408W WO 2004089353 A3 WO2004089353 A3 WO 2004089353A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
parkinson
safinamide
treatment
methods
Prior art date
Application number
PCT/IB2004/001408
Other languages
French (fr)
Other versions
WO2004089353A2 (en
WO2004089353A8 (en
Inventor
Fariello Ruggero
Carlo Cattaneo
Patricia Salvati
Luca Benatti
Original Assignee
Newron Pharmaceuticals Inc
Fariello Ruggero
Carlo Cattaneo
Patricia Salvati
Luca Benatti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33159845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004089353(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK04726590T priority Critical patent/DK1613296T3/en
Priority to SI200431192T priority patent/SI1613296T1/en
Priority to AT04726590T priority patent/ATE435012T1/en
Priority to KR1020057019264A priority patent/KR101129015B1/en
Priority to JP2006506582A priority patent/JP2006522800A/en
Priority to MXPA05010873A priority patent/MXPA05010873A/en
Priority to AU2004228782A priority patent/AU2004228782B2/en
Priority to NZ542910A priority patent/NZ542910A/en
Priority to EP04726590A priority patent/EP1613296B1/en
Priority to PL04726590T priority patent/PL1613296T3/en
Priority to BRPI0409364-0A priority patent/BRPI0409364A/en
Priority to DE602004021790T priority patent/DE602004021790D1/en
Priority to CA2523188A priority patent/CA2523188C/en
Priority to US10/559,982 priority patent/US8283380B2/en
Application filed by Newron Pharmaceuticals Inc, Fariello Ruggero, Carlo Cattaneo, Patricia Salvati, Luca Benatti filed Critical Newron Pharmaceuticals Inc
Publication of WO2004089353A2 publication Critical patent/WO2004089353A2/en
Publication of WO2004089353A3 publication Critical patent/WO2004089353A3/en
Publication of WO2004089353A8 publication Critical patent/WO2004089353A8/en
Priority to NO20054640A priority patent/NO334316B1/en
Priority to IL171331A priority patent/IL171331A/en
Priority to IL216403A priority patent/IL216403A/en
Priority to US13/594,621 priority patent/US8901176B2/en
Priority to NO20131417A priority patent/NO335537B1/en
Priority to US14/532,925 priority patent/US9492410B2/en
Priority to CY2015025C priority patent/CY2015025I1/en
Priority to FR15C0054C priority patent/FR15C0054I2/en
Priority to NO2015018C priority patent/NO2015018I1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

New uses of safinamide, safinamide derivatives and MAO-B inhibitors in novel types of treatment for Parkinson's Disease are described. More specifically, the invention relates to methods for treating Parkinson's Disease through the administration of safinamide, a safinamide derivative, or a MAO-B inhibitor, in combination with other Parkinson's Disease agents or treatments, such as levodopa/PDI or dopamine agonists.
PCT/IB2004/001408 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease WO2004089353A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
SI200431192T SI1613296T1 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
US10/559,982 US8283380B2 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
CA2523188A CA2523188C (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
KR1020057019264A KR101129015B1 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
JP2006506582A JP2006522800A (en) 2003-04-11 2004-04-08 Methods for treating Parkinson's disease
MXPA05010873A MXPA05010873A (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease.
AU2004228782A AU2004228782B2 (en) 2003-04-11 2004-04-08 Methods for treatment of Parkinson's Disease
NZ542910A NZ542910A (en) 2003-04-11 2004-04-08 Use of safinamide and levodopa for making a medicament for treatment of Parkinson's disease
EP04726590A EP1613296B1 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
PL04726590T PL1613296T3 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
BRPI0409364-0A BRPI0409364A (en) 2003-04-11 2004-04-08 Parkinson's disease treatment process
DE602004021790T DE602004021790D1 (en) 2003-04-11 2004-04-08 METHOD FOR TREATING PARKINSON DISEASE
AT04726590T ATE435012T1 (en) 2003-04-11 2004-04-08 METHOD FOR TREATING PARKINSON'S DISEASE
DK04726590T DK1613296T3 (en) 2003-04-11 2004-04-08 Methods for treating Parkinson's disease
IL171331A IL171331A (en) 2003-04-11 2005-10-10 Use of a combination comprising safinamide and levodopa/pdi in the manufacture of a medicament for treating parkinson's disease and compositions and a kit comprising said combination for such a treatment
NO20054640A NO334316B1 (en) 2003-04-11 2005-10-10 Use of safinamide in combination with levodopa / PDI for the manufacture of medications for the treatment of Parkinson's disease
IL216403A IL216403A (en) 2003-04-11 2011-11-17 Pharmaceutical composition in combined form comprising salfinamide and a dopamine agonist and uses thereof
US13/594,621 US8901176B2 (en) 2003-04-11 2012-08-24 Methods for treatment of Parkinson's disease
NO20131417A NO335537B1 (en) 2003-04-11 2013-10-28 Use of safinamide for the manufacture of medications for the treatment of Parkinson's disease
US14/532,925 US9492410B2 (en) 2003-04-11 2014-11-04 Methods for treatment of Parkinson's disease
CY2015025C CY2015025I1 (en) 2003-04-11 2015-07-01 METHODS FOR THE TREATMENT OF PARKINSON'S DISEASE
FR15C0054C FR15C0054I2 (en) 2003-04-11 2015-07-22 METHODS OF TREATMENT OF PARKINSON’S DISEASE
NO2015018C NO2015018I1 (en) 2003-04-11 2015-07-23 Safinamide for use in combination with levodopa / DPI and possibly with other PD medical products for the treatment of Parkinson's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46220503P 2003-04-11 2003-04-11
US60/462,205 2003-04-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/559,982 A-371-Of-International US8283380B2 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease
US13/594,621 Division US8901176B2 (en) 2003-04-11 2012-08-24 Methods for treatment of Parkinson's disease

Publications (3)

Publication Number Publication Date
WO2004089353A2 WO2004089353A2 (en) 2004-10-21
WO2004089353A3 true WO2004089353A3 (en) 2004-12-16
WO2004089353A8 WO2004089353A8 (en) 2005-09-01

Family

ID=33159845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/001408 WO2004089353A2 (en) 2003-04-11 2004-04-08 Methods for treatment of parkinson's disease

Country Status (28)

Country Link
US (3) US8283380B2 (en)
EP (2) EP1613296B1 (en)
JP (2) JP2006522800A (en)
KR (2) KR20110070929A (en)
CN (2) CN1771030A (en)
AR (1) AR044007A1 (en)
AT (1) ATE435012T1 (en)
AU (1) AU2004228782B2 (en)
BR (1) BRPI0409364A (en)
CA (1) CA2523188C (en)
CY (3) CY1109295T1 (en)
DE (1) DE602004021790D1 (en)
DK (2) DK1613296T3 (en)
ES (2) ES2454272T3 (en)
FR (1) FR15C0054I2 (en)
HU (1) HUS1500043I1 (en)
IL (2) IL171331A (en)
LU (1) LU92782I2 (en)
MX (1) MXPA05010873A (en)
NL (1) NL300752I2 (en)
NO (3) NO334316B1 (en)
NZ (1) NZ542910A (en)
PL (2) PL2070526T3 (en)
PT (2) PT2070526E (en)
RU (1) RU2342929C2 (en)
SI (2) SI1613296T1 (en)
TW (1) TWI340640B (en)
WO (1) WO2004089353A2 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
DE602004025586D1 (en) * 2003-08-25 2010-04-01 Newron Pharm Spa ALPHA-AMINOAMIDE DERIVATIVES FOR USE AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (en) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. Pharmaceutical composition useful as sodium and/or calcium channel selective modulators comprising (halobenzyloxy) benzylamino-propanamides
US20070004639A1 (en) * 2005-07-01 2007-01-04 Bodybio, Inc. Methods and compositions for treating Parkinson's disease
WO2007069274A2 (en) * 2005-11-09 2007-06-21 Torrent Pharmaceuticals Limited Pharmaceutical composition comprising a compound having a catechol moiety and an alkalising agent
RU2397160C9 (en) * 2005-12-22 2012-10-27 НЬЮРОН ФАРМАСЬЮТИКАЛЗ С.п.А. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
CN101032474B (en) * 2006-03-06 2011-02-16 重庆医药工业研究院有限责任公司 Rasagiline transparent patch for curing and preventing neurological diseases and the preparing method thereof
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
US8106056B2 (en) * 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
PL2029524T3 (en) 2006-06-19 2015-04-30 Newron Pharm Spa Process for the production of 2- [4 - ( 3- and 2-fluorobenzyloxy) benzylamino] propan amides
DE102007014947B4 (en) * 2007-03-23 2010-05-27 Axxonis Pharma Ag Stabilized aqueous solutions of ergoline compounds
EP2150239A1 (en) * 2007-04-24 2010-02-10 Boehringer Ingelheim International GmbH Combination with an extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof
HUE038113T2 (en) 2007-06-15 2018-09-28 Newron Pharm Spa Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives and their use as sodium and/or calcium channel modulators
GB2453770A (en) * 2007-10-19 2009-04-22 Reckitt Benckiser Healthcare Oral composition comprising a cooling agent
WO2009054964A1 (en) * 2007-10-22 2009-04-30 Concert Pharmaceuticals, Inc. Alpha-aminoamide derivatives
CN101896456B (en) 2007-12-11 2014-10-22 纽朗制药有限公司 Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
EA019529B1 (en) * 2007-12-19 2014-04-30 Ньюрон Фармасьютикалс С.П.А. Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders
US20110027354A1 (en) * 2008-04-01 2011-02-03 Kim Hyoung-Chun Anti-parkinsonian compounds
EP2285769B1 (en) 2008-06-02 2014-08-13 Generics [UK] Limited A process for the preparation of enantiomerically pure amines
AU2009254929B2 (en) * 2008-06-02 2014-03-13 Generics [Uk] Limited An improved process for the preparation of amines
AU2009254730B2 (en) * 2008-06-06 2014-06-26 Pharma Two B Ltd. Pharmaceutical compositions for treatment of Parkinson's disease
EA201170018A1 (en) * 2008-06-13 2011-08-30 Тева Фармасьютикал Индастриз, Лтд. Razagilin to change the flow of Parkinson's disease
WO2010010138A1 (en) * 2008-07-24 2010-01-28 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising pramipexole and a calcium channel blocker for the treatment of parkinson's disease
US20100189791A1 (en) * 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline malate formulation
EP2218444A3 (en) * 2009-01-23 2010-08-25 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline formulation
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
CN102048717B (en) 2009-10-29 2014-02-19 重庆医药工业研究院有限责任公司 Stable rasagiline composition
WO2011098456A1 (en) 2010-02-09 2011-08-18 Merck Serono S.A. Safinamide in the treatment of dyskinesia
DK2563355T3 (en) 2010-04-27 2016-09-12 Newron Pharm Spa A process for the preparation of ralfinamide-methanesulphonate or R-enantiomers thereof.
JP5820469B2 (en) 2010-04-30 2015-11-24 テイコク ファーマ ユーエスエー インコーポレーテッド Transdermal composition of propynylaminoindane
CN103476404B (en) 2011-03-24 2017-09-29 帝国制药美国公司 Transdermal composition comprising active agent layer and activating agent conversion coating
WO2013081685A1 (en) 2011-08-19 2013-06-06 The Trustees Of Princeton University C-halogen bond formation
US20150031768A1 (en) * 2011-08-19 2015-01-29 The Trustees Of Princeton University C-halogen bond formation
US9913812B2 (en) 2011-11-09 2018-03-13 Teikoku Pharma Usa, Inc. Methods for the treatment of skin neoplasms
CA2887705C (en) 2012-11-02 2018-07-24 Teikoku Pharma Usa, Inc. Propynylaminoindan transdermal compositions
US9155695B2 (en) 2013-03-14 2015-10-13 Medtronic, Inc. Injectable ropinirole compositions and methods for making and using same
KR20160026897A (en) 2013-06-27 2016-03-09 세다르스-신나이 메디칼 센터 Adrenoceptors antagonists
CA2946165C (en) * 2014-04-21 2022-10-18 Civitas Therapeutics, Inc. Rapid relief of motor fluctuations in parkinson's disease
EP3202759B1 (en) * 2014-10-02 2019-12-18 Megabiowood Co., Ltd. Alpha-aminoamide derivative compound and pharmaceutical composition containing the same
ES2764490T3 (en) * 2015-08-27 2020-06-03 Prexton Therapeutics Sa Derived from chromone oxime that penetrates the brain for therapy of levodopa-induced dyskinesia
EP3429569A4 (en) * 2016-03-17 2020-02-26 The Johns Hopkins University Methods for preventing or treating parkinson's disease by the farnesylation of paris
ITUA20163981A1 (en) 2016-05-31 2017-12-01 Zambon Spa PHARMACEUTICAL COMPOSITIONS INCLUDING SAFINAMID
WO2018132746A1 (en) * 2017-01-14 2018-07-19 Mischley Laurie Kathern Method of using human excrement and secretions for early detection of parkinson's disease
CN109251155A (en) * 2017-07-14 2019-01-22 广东东阳光药业有限公司 Alpha-aminoamide derivatives and application thereof
WO2019036624A1 (en) * 2017-08-17 2019-02-21 Gu Zi Qiang Pamoate salt of monoamine anti-parkinson's agents, method of preparation and use thereof
CA3080975A1 (en) 2017-11-02 2019-05-09 Zambon S.P.A. Pharmaceutical compositions comprising safinamide
KR102005019B1 (en) * 2018-04-04 2019-07-31 한국과학기술연구원 A composition for preventing and treating stroke
CN114727647A (en) * 2019-09-12 2022-07-08 阿奇维生命科学公司 Compositions comprising cytisine for treating and/or preventing addiction in a subject in need thereof
CN110938014A (en) * 2019-11-28 2020-03-31 岳千奥 Substituted phenoxyamide derivative, application and medicine for treating Parkinson's disease
WO2021109880A1 (en) * 2019-12-06 2021-06-10 上海医药集团股份有限公司 Pharmaceutical composition, complementary kit and application thereof
CN110999980A (en) * 2019-12-19 2020-04-14 新疆石河子职业技术学院（石河子市技工学校） Wine wash-dipped cheese processing method
EP4203939A4 (en) * 2020-08-31 2024-11-06 Purdue Pharma Lp Compositions and methods for levodopa delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400495A1 (en) * 1989-05-25 1990-12-05 FARMITALIA CARLO ERBA S.r.l. N-phenylalkyl substituted alfa-amino carboxamide derivatives and process for their preparation
US5945454A (en) * 1995-07-27 1999-08-31 Pharmacia & Upjohn, S.P.A. 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US3795739A (en) * 1972-02-14 1974-03-05 Hoffmann La Roche Treatment of parkinson disease
US4049663A (en) 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
FR2480747A1 (en) 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
US4935429A (en) 1985-10-25 1990-06-19 Dackis Charles A Method of treating psychostimulant addiction
EP0252290B1 (en) * 1986-06-10 1992-06-03 CHIESI FARMACEUTICI S.p.A. Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof
CA1336169C (en) 1988-03-01 1995-07-04 Walther Birkmayer Agent for treatment of parkinson's disease
US5221536A (en) * 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
US5502658A (en) 1990-12-27 1996-03-26 Relin; Arkadi Sampled-continuous probability method of velocity measurement of the object having informatively-structural inhomogeneity
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
IL111240A (en) * 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
MX9709112A (en) * 1995-05-26 1998-02-28 Pfizer Combinations for the treatment of parkinsonism containing selective nmda antagonists.
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
FI109453B (en) 1999-06-30 2002-08-15 Orion Yhtymae Oyj Pharmaceutical composition
US20020019421A1 (en) * 2000-07-05 2002-02-14 Roni Biberman Compositions and therapy for substance addiction
DE10041479A1 (en) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh New pharmaceutical composition for the administration of N-0923
FR2829027A1 (en) * 2001-08-29 2003-03-07 Aventis Pharma Sa ASSOCIATION WITH A CB1 RECEPTOR ANTAGONIST, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE TREATMENT OF PARKINSON'S DISEASE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400495A1 (en) * 1989-05-25 1990-12-05 FARMITALIA CARLO ERBA S.r.l. N-phenylalkyl substituted alfa-amino carboxamide derivatives and process for their preparation
US5391577A (en) * 1989-05-25 1995-02-21 Farmitalia Carlo Erba S R L N-phenylalkyl substituted α-amino carboxamide derivatives and process for their preparation
US5945454A (en) * 1995-07-27 1999-08-31 Pharmacia & Upjohn, S.P.A. 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Newron Releases Positive Preliminary Phase II Data for Salfinamide in Parkinson's Disease", PRESS RELEASE OF 03.01.03, XP002290820, Retrieved from the Internet <URL:http://www.newron.com/press.asp?Action=news&intNewsID=1> [retrieved on 20040801] *

Also Published As

Publication number Publication date
MXPA05010873A (en) 2006-03-21
PT1613296E (en) 2009-07-30
TW200505423A (en) 2005-02-16
LU92782I2 (en) 2015-09-22
NO20054640D0 (en) 2005-10-10
KR101129015B1 (en) 2012-04-20
US20150150833A1 (en) 2015-06-04
SI2070526T1 (en) 2014-05-30
CA2523188C (en) 2012-09-25
EP1613296A2 (en) 2006-01-11
NO2015018I2 (en) 2015-07-23
AU2004228782B2 (en) 2010-05-20
CN102274517A (en) 2011-12-14
PT2070526E (en) 2014-03-31
US9492410B2 (en) 2016-11-15
IL216403A (en) 2015-01-29
EP2070526B1 (en) 2014-02-26
WO2004089353A2 (en) 2004-10-21
NO20131417L (en) 2005-12-09
NO335537B1 (en) 2014-12-22
PL2070526T3 (en) 2014-08-29
CY2015025I2 (en) 2016-04-13
CA2523188A1 (en) 2004-10-21
CY1109295T1 (en) 2014-07-02
RU2005131422A (en) 2006-04-27
ES2326373T3 (en) 2009-10-08
CN102274517B (en) 2018-08-31
JP2013067647A (en) 2013-04-18
AU2004228782A1 (en) 2004-10-21
WO2004089353A8 (en) 2005-09-01
ATE435012T1 (en) 2009-07-15
SI1613296T1 (en) 2009-10-31
NZ542910A (en) 2007-10-26
CY2015025I1 (en) 2016-04-13
US8283380B2 (en) 2012-10-09
PL1613296T3 (en) 2009-12-31
EP2070526A1 (en) 2009-06-17
AR044007A1 (en) 2005-08-24
IL216403A0 (en) 2011-12-29
EP1613296B1 (en) 2009-07-01
ES2454272T3 (en) 2014-04-10
TWI340640B (en) 2011-04-21
NL300752I2 (en) 2016-07-05
NO2015018I1 (en) 2015-08-03
HUS1500043I1 (en) 2018-11-28
KR20060010745A (en) 2006-02-02
FR15C0054I2 (en) 2018-01-26
NO334316B1 (en) 2014-02-03
NO20054640L (en) 2005-12-09
US20070093495A1 (en) 2007-04-26
RU2342929C2 (en) 2009-01-10
KR20110070929A (en) 2011-06-24
CN1771030A (en) 2006-05-10
US8901176B2 (en) 2014-12-02
DK2070526T3 (en) 2014-03-24
IL171331A (en) 2012-03-29
DK1613296T3 (en) 2009-10-05
BRPI0409364A (en) 2006-04-25
US20130053368A1 (en) 2013-02-28
JP2006522800A (en) 2006-10-05
CY1115286T1 (en) 2017-01-04
DE602004021790D1 (en) 2009-08-13
FR15C0054I1 (en) 2015-11-09

Similar Documents

Publication Publication Date Title
WO2004089353A3 (en) Methods for treatment of parkinson&#39;s disease
BRPI0408902A (en) selective cyclooxygenase-2 inhibitor compositions and 5-ht 1b / 1d agonists for the treatment and prevention of migraine
WO2005089502A3 (en) Methods for the treatment of synucleinopathies
IL173712A (en) Transdermal pharmaceutical preparation containing active substance combinations for treating parkinson&#39;s disease
WO2005089504A3 (en) Methods for the treatment of synucleinopathies
AU2002302587A1 (en) Acne treatment with lipooxigenase inhibitors
EA200601746A1 (en) APPLICATION OF ROTIGOTINE FOR THE TREATMENT AND PREVENTION OF THE PARKINSONISM-PLUS SYNDROME
BRPI0508254A (en) methods and compositions for treating or preventing psychiatric disorders with cox-2 inhibitors alone and in combination with antidepressant agents
WO2007093450A3 (en) Deuterated catecholamine derivatives and medicaments comprising said compounds
TW200420549A (en) Thiazole derivatives
WO2005089515A3 (en) Methods for the treatment of synucleinopathies
WO2004047838A3 (en) Pharmaceutical composition comprising beta-3-adrenoceptor agonists and antimuscarinic agents
WO2003059294A3 (en) Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
WO2007005737A3 (en) Amine oxidase inhibitors
WO2003094909A3 (en) Methods and compositions for the treatment and prevention of intermittent claudication or alzheimer&#39;s disease
WO2008070010A3 (en) Hydroxylamine derivatives for the treatment of stroke
HK1086548A1 (en) Deuterated catecholamine derivatives and medicaments comprising said compounds
WO2004052858A3 (en) Inhibitors of monoamine uptake
WO2009047505A3 (en) Dexanabinol with inhibitors of braf or mek for the treatment of melanoma
WO2007095611A3 (en) Use of benzo-fused heteroaryl sulfamide derivatives for the treatment of migraine
WO2005042718A3 (en) Compositions and methods for treating, preventing, reversing and inhibiting pain
WO2007117272A3 (en) Methods for treatment of hemorrhagic shock and related disorders
WO2007084383A3 (en) Method and composition for the treatment of parkinson&#39;s disease
EP1260221A3 (en) Combination treatment for depression and anxiety
TW200509918A (en) Treatment of depression and other affective disorders

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 43/2004 UNDER (81) ADD "US"

WWE Wipo information: entry into national phase

Ref document number: 2004726590

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2523188

Country of ref document: CA

Ref document number: 2006506582

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2005131422

Country of ref document: RU

Ref document number: 2004228782

Country of ref document: AU

Ref document number: 542910

Country of ref document: NZ

Ref document number: 1020057019264

Country of ref document: KR

Ref document number: 2004809655X

Country of ref document: CN

Ref document number: 171331

Country of ref document: IL

Ref document number: PA/a/2005/010873

Country of ref document: MX

Ref document number: 4581/DELNP/2005

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2004228782

Country of ref document: AU

Date of ref document: 20040408

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004228782

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2004726590

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007093495

Country of ref document: US

Ref document number: 10559982

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1020057019264

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0409364

Country of ref document: BR

WWP Wipo information: published in national office

Ref document number: 10559982

Country of ref document: US