WO2004084735A1 - Deriving parameter information from blood flow signal - Google Patents

Deriving parameter information from blood flow signal Download PDF

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Publication number
WO2004084735A1
WO2004084735A1 PCT/AU2004/000343 AU2004000343W WO2004084735A1 WO 2004084735 A1 WO2004084735 A1 WO 2004084735A1 AU 2004000343 W AU2004000343 W AU 2004000343W WO 2004084735 A1 WO2004084735 A1 WO 2004084735A1
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WO
WIPO (PCT)
Prior art keywords
flow
parameters
triangular shape
background image
points
Prior art date
Application number
PCT/AU2004/000343
Other languages
French (fr)
Inventor
Paul Butler
Robert Allan Phillips
Gary Davey
Original Assignee
Uscom Limited
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Publication date
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Publication of WO2004084735A1 publication Critical patent/WO2004084735A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/02Measuring pulse or heart rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06Measuring blood flow
    • A61B8/065Measuring blood flow to determine blood output from the heart
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • G01S7/52017Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
    • G01S7/52053Display arrangements
    • G01S7/52057Cathode ray tube displays
    • G01S7/52073Production of cursor lines, markers or indicia by electronic means

Definitions

  • the present invention relates to the field of signal monitoring and, in particular, discloses a method and apparatus for deriving parameter information from a signal.
  • Blood flow within the human body is cyclic and is responsive to the changing pressures generated by contraction and relaxation of the heart muscles. This cyclic contraction and relaxation produces pulsating blood flow.
  • Known Doppler ultrasound techniques can measure the phase shift associated with this flow and display the signal on a screen.
  • An example of such a system is provided in Patent Cooperation Treaty Publication Number WO 99/66835 entitled “Ultrasonic Cardiac Output Monitor", the publication of which is incorporated herein by cross-reference.
  • the Doppler Ultrasound flow profiles provide important clinical information.
  • An example of a time v. velocity flow profile is shown in Fig. 1 for a measurement taken utilising the technique of the aforementioned PCT Publication.
  • any derived parameters are currently measured using a manual trace method so as to provide multiple haemodynamic parameters reflecting the underlying flow characteristics.
  • This measurement can be time consuming and depends for accuracy upon the mechanical co-ordination of the operator. Cardiac contraction and relaxation varies both in rate and force from beat to beat, so a comprehensive understanding of the function may require multiple sequential or serial measurements.
  • a method for measuring parameters in a Doppler Flow Profile utilising a computer display device, the method comprising the steps of: (a) displaying a background image of the Doppler flow profile on the display device; (b) displaying a series of interactive graphical objects over the background image, the elements having adjustable position parameters; (c) providing an interactive capability for a user to adjust the position of portions of the graphical elements; (d) calculating the parameters from the relative position of the portions of the graphical elements.
  • the interactive graphical objects can include a first object substantially intersecting the apex of a series of adjacent Doppler flow profiles.
  • At least one of the interactive graphical objects preferably can include a substantially triangular shape sized substantially to fit around an initial portion of a flow cycle.
  • the apex of the triangular shape can be located substantially at the peak flow velocity of the background image.
  • At least one of the interactive graphical objects further preferably can include a segment from a base of the triangular shape to an adjacent initial portion of a flow cycle.
  • the triangular shape preferably can include a series of manipulation points along at least one side thereof.
  • Fig. 1 illustrates an example Doppler Flow Profile
  • Fig. 2 illustrates the utilisation of template structures in conjunction with a Doppler flow profile
  • Fig. 3 illustrates one example computer architecture on which the preferred embodiment can be carried out.
  • the preferred embodiment provides a semi-automated digital method for measuring Doppler flow profiles which is quicker and often more accurate than the current manual methods.
  • Fig. 2 the preferred embodiment provides for the overlay of various template structures on a standard received flow profile e.g. 1.
  • the profile 1 can be a screen snapshot taken from a Doppler flow measurement unit.
  • a simple flow template is presented having interconnected structural elements 2,3.
  • the elements 2,3 being shown for the characterising of a normal flow profile, being a simple systolic ejection cycle for transpulmonary and transaortic flow.
  • templates can be provided. For example, a biphasic pattern is selected for transmitral flow and a monophasic pattern for transmitral flow in atrial fibrillation.
  • a user interface and template can be provided for selecting the appropriate profile.
  • the template components 3 are initially interconnected at an intersection 4 representing the peak flow velocity. The point 4 is adjustable by the user in the vertical direction.
  • the component 2 forms an adjustable base line and is constrained to be always horizontal.
  • the template also includes adjustable points 5,6,7,8, 9.
  • the points 5,6,7 are movable along the base line 2.
  • the points 8,9 are moveable in a horizontal manner and control attached line segments.
  • each point 4-9 there is a digital handle which can be moved by mouse in the instance of conventional digital display, or by stylus if the application is for touch screen display, to allow for exact superimposition of the template point over the underlying flow profile.
  • velocity, mean pressure gradient, velocity time integral, ejection time and heart rate can be calculated.
  • the input of other clinical variables by a user allows for derivation of other clinically useful haemodynamic variables such as stroke volume and cardiac output.
  • the template can remain on the screen as the Doppler flow signal is re-activated, allowing for a simple visual comparison of the real time signal with the prior measurements.
  • the streaming Doppler signal can be frozen, and the entire template moved in a single action to superimpose the new flow profile for measurement. Minor adjustments using the digital handles ensures accurate superimposition of the new flow profile and a new set of variables can be derived. The minor adjustments can thereby result in a recalculation of the template points.
  • This touchpoint method of tracing simple geometric screen elements allows for rapid, and reproducible measurement of important cardiac haemodynamic Doppler flow profiles.
  • the method can also be utilised in any screen measurement of a simple geometric
  • This method is able to improve the currently practiced direct trace of these profiles which is both time consuming and dependent on the co-ordination skills of the operator.
  • the application of this method has significant time and cost effectiveness consequences in a variety of applications where rapid and accurate tracing of displayed signals is required.
  • the preferred embodiment can be implemented by suitable programming of an interactive graphics package by the skilled graphics programmer.
  • the implementation can be formulated, for example, in Visual C++, TCL/TK etc.
  • the preferred embodiment is preferably implemented on a standard workstation type computer arrangement utilising standard computer graphics programming languages.
  • a suitable hardware arrangement for programming can be as shown in Fig. 3 with central processing unit 41, memory 42, Disk store 43 and IO Device Controller 44 arranged around a central bus 45.
  • the arrangement 40 can be suitably programmed in the usual manner to carry out the operations of the preferred embodiment.
  • each point can be fully moveable, preferably when first used, various defaults are provided.
  • the points 8 and 9 shall always have their Y coordinate halfway between the points 5 and 4.
  • the points 5, 6, 7 shall always have their Y coordinate equal to the 0 level on the scale.
  • the default sizes can be as set out in the following table:
  • the user moves the 6 points of the template to encompass the flow pattern on the flow display. All points shall be able to be dragged to a valid location.
  • the valid locations for points are
  • Point 5 must be to the left or equal to 8
  • Point 8 must be between points 5 and 4
  • Point 4 must be between points 8 and 9
  • Point 9 must be between points 4 and 6 •
  • Point 6 must be between points 9 and 7
  • Point 7 must be to the left of point 5 This shall be achieved by moving the 6 points as follows

Abstract

A method for measuring parameters in a Doppler Flow Profile utilising a computer display device, the method comprising the steps of: (a) displaying a background image of the Doppler flow profile on the display device; (b) displaying a series of interactive graphical objects over the background image, the elements having adjustable position parameters; (c) providing an interactive capability for a user to adjust the position of portions of the graphical elements; (d) calculating the parameters from the relative position of the portions of the graphical elements.

Description

DERIVING PARAMETER INFORMATION FROM BLOOD FLOW SIGNAL
Field of the Invention The present invention relates to the field of signal monitoring and, in particular, discloses a method and apparatus for deriving parameter information from a signal. Background of the Invention
Blood flow within the human body is cyclic and is responsive to the changing pressures generated by contraction and relaxation of the heart muscles. This cyclic contraction and relaxation produces pulsating blood flow. Known Doppler ultrasound techniques can measure the phase shift associated with this flow and display the signal on a screen. An example of such a system is provided in Patent Cooperation Treaty Publication Number WO 99/66835 entitled "Ultrasonic Cardiac Output Monitor", the publication of which is incorporated herein by cross-reference.
The Doppler Ultrasound flow profiles provide important clinical information. An example of a time v. velocity flow profile is shown in Fig. 1 for a measurement taken utilising the technique of the aforementioned PCT Publication. Unfortunately, it is often the case that any derived parameters are currently measured using a manual trace method so as to provide multiple haemodynamic parameters reflecting the underlying flow characteristics. This measurement can be time consuming and depends for accuracy upon the mechanical co-ordination of the operator. Cardiac contraction and relaxation varies both in rate and force from beat to beat, so a comprehensive understanding of the function may require multiple sequential or serial measurements.
Fully automated edge detection methods have been used with limited success in peripheral vessel and simple flow applications, however intracardiac flow is characterised by artefacts which are random and cannot be easily described using fully automated methods. Automated methods are generally not positively accepted in clinical practice because of the inherent error and insensitivity.
Summary of the Invention It is an object of the present invention to provide an alternative form of deriving
parameters from a signal output device.
In accordance with a first aspect of the present invention, there is provided a method for measuring parameters in a Doppler Flow Profile utilising a computer display device, the method comprising the steps of: (a) displaying a background image of the Doppler flow profile on the display device; (b) displaying a series of interactive graphical objects over the background image, the elements having adjustable position parameters; (c) providing an interactive capability for a user to adjust the position of portions of the graphical elements; (d) calculating the parameters from the relative position of the portions of the graphical elements. The interactive graphical objects can include a first object substantially intersecting the apex of a series of adjacent Doppler flow profiles. At least one of the interactive graphical objects preferably can include a substantially triangular shape sized substantially to fit around an initial portion of a flow cycle. The apex of the triangular shape can be located substantially at the peak flow velocity of the background image. At least one of the interactive graphical objects further preferably can include a segment from a base of the triangular shape to an adjacent initial portion of a flow cycle. The triangular shape preferably can include a series of manipulation points along at least one side thereof.
Brief Description of the Drawings Preferred embodiments of the present invention will now be described by way of example only with reference to the accompanying drawings in which: Fig. 1 illustrates an example Doppler Flow Profile; Fig. 2 illustrates the utilisation of template structures in conjunction with a Doppler flow profile; and
Fig. 3 illustrates one example computer architecture on which the preferred embodiment can be carried out.
Description of the Preferred and Other Embodiments The preferred embodiment provides a semi-automated digital method for measuring Doppler flow profiles which is quicker and often more accurate than the current manual methods.
Turning to Fig. 2, the preferred embodiment provides for the overlay of various template structures on a standard received flow profile e.g. 1. The profile 1 can be a screen snapshot taken from a Doppler flow measurement unit. As shown in Fig. 2, on top of the profile 1, a simple flow template is presented having interconnected structural elements 2,3. The elements 2,3 being shown for the characterising of a normal flow profile, being a simple systolic ejection cycle for transpulmonary and transaortic flow.
When alternative flows are visualised, other templates can be provided. For example, a biphasic pattern is selected for transmitral flow and a monophasic pattern for transmitral flow in atrial fibrillation. A user interface and template can be provided for selecting the appropriate profile. The template components 3 are initially interconnected at an intersection 4 representing the peak flow velocity. The point 4 is adjustable by the user in the vertical direction.
The component 2 forms an adjustable base line and is constrained to be always horizontal. The template also includes adjustable points 5,6,7,8, 9. The points 5,6,7 are movable along the base line 2. The points 8,9 are moveable in a horizontal manner and control attached line segments.
At each point 4-9 there is a digital handle which can be moved by mouse in the instance of conventional digital display, or by stylus if the application is for touch screen display, to allow for exact superimposition of the template point over the underlying flow profile.
From the positioning of the template points, a number of conventional haemodynamic parameters such as peak flow velocity, mean flow velocity, peak flow
velocity, mean pressure gradient, velocity time integral, ejection time and heart rate can be calculated. The input of other clinical variables by a user allows for derivation of other clinically useful haemodynamic variables such as stroke volume and cardiac output.
Once the template is adjusted to superimpose the underlying flow profile, the template can remain on the screen as the Doppler flow signal is re-activated, allowing for a simple visual comparison of the real time signal with the prior measurements. When further measurements are required the streaming Doppler signal can be frozen, and the entire template moved in a single action to superimpose the new flow profile for measurement. Minor adjustments using the digital handles ensures accurate superimposition of the new flow profile and a new set of variables can be derived. The minor adjustments can thereby result in a recalculation of the template points.
This touchpoint method of tracing simple geometric screen elements, allows for rapid, and reproducible measurement of important cardiac haemodynamic Doppler flow profiles.
The method can also be utilised in any screen measurement of a simple geometric
signal, which will include Doppler flow profiles from other vessels in the body. This method is able to improve the currently practiced direct trace of these profiles which is both time consuming and dependent on the co-ordination skills of the operator. The application of this method has significant time and cost effectiveness consequences in a variety of applications where rapid and accurate tracing of displayed signals is required.
The preferred embodiment can be implemented by suitable programming of an interactive graphics package by the skilled graphics programmer. The implementation can be formulated, for example, in Visual C++, TCL/TK etc. The preferred embodiment is preferably implemented on a standard workstation type computer arrangement utilising standard computer graphics programming languages. A suitable hardware arrangement for programming can be as shown in Fig. 3 with central processing unit 41, memory 42, Disk store 43 and IO Device Controller 44 arranged around a central bus 45. The arrangement 40 can be suitably programmed in the usual manner to carry out the operations of the preferred embodiment.
Whilst each point can be fully moveable, preferably when first used, various defaults are provided. For example, the points 8 and 9 shall always have their Y coordinate halfway between the points 5 and 4. The points 5, 6, 7 shall always have their Y coordinate equal to the 0 level on the scale. The default sizes can be as set out in the following table:
Figure imgf000008_0001
Table 2 Default Touchpoint
Where • 5 to 6 distance = 0.4 seconds
• 5 to 4 distance - 220/256 of the 0 to lower scale distance
• 6 to 7 distance = 0.9 seconds - 5 to 6 distance
The user moves the 6 points of the template to encompass the flow pattern on the flow display. All points shall be able to be dragged to a valid location. The valid locations for points are
Point 5 must be to the left or equal to 8 Point 8 must be between points 5 and 4 Point 4 must be between points 8 and 9 Point 9 must be between points 4 and 6 • Point 6 must be between points 9 and 7
Point 7 must be to the left of point 5 This shall be achieved by moving the 6 points as follows
• Touching to the right of midway between points 5 and 7 shall move the 7 point in a Y direction to the position of the touch • Touching to the left of midway between points 6 and 7 or to the right of midway between points 6 and 9 shall move the 6 point in a Y direction to the position of the touch.
• Touching to the left of midway between points 9 and 6 or to the right if midway between points 9 and 4 shall move the 9 point in a Y direction to the position of the touch.
• Touching below the midway between point 8/9 and 4 will move point 4 to the position of the touch. The 4 point can be moved in an X and Y direction. When the Y location of the 4 point is moved the Y position of the 8 and 9 points shall be re-located to be halfway in the Y plane between points 5 and 4
• Touching to the left of midway between points 8 and 5 or to the right of midway between points 8 and 4 shall move the 8 point in a Y direction to the position of the touch.
• Touching to the right of midway between points 5 and 8 shall move the 5 point in a Y direction to the position of the touch.
The following measures shall be calculated from the Touchpoint
Figure imgf000009_0001
Table 3 Measures The forgoing describes only one embodiment of the present invention. Modifications, obvious to those skilled in the art, can be made thereto without departing from the scope of the invention.

Claims

We claim:
1. A method for measuring parameters in a Doppler Flow Profile utilising a computer display device, the method comprising the steps of:
(a) displaying a background image of the Doppler flow profile on the display device;
(b) displaying a series of interactive graphical objects over the background image, said elements having adjustable position parameters;
(c) providing an interactive capability for a user to adjust the position of portions
of said graphical elements; (d) calculating the parameters from the relative position of said portions of said graphical elements.
2. A method as claimed in claim 1 wherein said interactive graphical objects include a first object substantially intersecting the apex of a series of adjacent Doppler flow profiles.
3. A method as claimed in any previous claim wherein at least one of said interactive graphical objects includes a substantially triangular shape sized substantially to fit around an initial portion of a flow cycle.
4. A method as claimed in claim 3 wherein the apex of said triangular shape is
located substantially at the peak flow velocity of the background image.
5. A method as claimed in claim 3 wherein said at least one of said interactive graphical objects further includes a segment from a base of said triangular shape to an adjacent initial portion of a flow cycle.
6. A method as claimed in claim 3 wherein said triangular shape includes a series of manipulation points along at least one side thereof.
7. A method substantially as hereinbefore described with reference to the accompanying drawings.
8. A computer system when implementing the method of any of claims 1 to 7.
PCT/AU2004/000343 2003-03-25 2004-03-19 Deriving parameter information from blood flow signal WO2004084735A1 (en)

Applications Claiming Priority (2)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017154008A1 (en) * 2016-03-10 2017-09-14 Bar-Ilan University Method and system of automatic analysis of doppler echocardiography images
US10405805B2 (en) 2013-01-14 2019-09-10 Uscom Limited Combined blood flow and pressure monitoring system and method
US11020093B2 (en) 2016-03-23 2021-06-01 Koninklijke Philips N.V. Method and apparatus for improving the measurement of flow velocity of blood

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20030114756A1 (en) * 2001-12-18 2003-06-19 Xiang-Ning Li Method and system for ultrasound blood flow imaging and volume flow calculations
WO2003060553A2 (en) * 2001-12-28 2003-07-24 Koninklijke Philips Electronics N.V. Viewing system having means for processing a sequence of ultrasound images for performing a quantitative estimation of a flow in a body organ

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114756A1 (en) * 2001-12-18 2003-06-19 Xiang-Ning Li Method and system for ultrasound blood flow imaging and volume flow calculations
WO2003060553A2 (en) * 2001-12-28 2003-07-24 Koninklijke Philips Electronics N.V. Viewing system having means for processing a sequence of ultrasound images for performing a quantitative estimation of a flow in a body organ

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10405805B2 (en) 2013-01-14 2019-09-10 Uscom Limited Combined blood flow and pressure monitoring system and method
WO2017154008A1 (en) * 2016-03-10 2017-09-14 Bar-Ilan University Method and system of automatic analysis of doppler echocardiography images
US11020093B2 (en) 2016-03-23 2021-06-01 Koninklijke Philips N.V. Method and apparatus for improving the measurement of flow velocity of blood

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