WO2004078928A3 - T cell regulation - Google Patents

T cell regulation Download PDF

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Publication number
WO2004078928A3
WO2004078928A3 PCT/US2004/006133 US2004006133W WO2004078928A3 WO 2004078928 A3 WO2004078928 A3 WO 2004078928A3 US 2004006133 W US2004006133 W US 2004006133W WO 2004078928 A3 WO2004078928 A3 WO 2004078928A3
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WO
WIPO (PCT)
Prior art keywords
cells
lag
treg
expression
regulatory
Prior art date
Application number
PCT/US2004/006133
Other languages
French (fr)
Other versions
WO2004078928A2 (en
Inventor
Drew M Pardoll
Ching-Tai Huang
Dario A Vignali
Greg J Workman
Jonathan Powell
Charles C Drake
Original Assignee
Drew M Pardoll
Ching-Tai Huang
Dario A Vignali
Greg J Workman
Jonathan Powell
Charles C Drake
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32966451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004078928(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP07021595.9A priority Critical patent/EP1897548B2/en
Priority to AU2004217526A priority patent/AU2004217526B2/en
Priority to EP04716126A priority patent/EP1596871A4/en
Priority to JP2006508934A priority patent/JP2006523226A/en
Priority to CA2517287A priority patent/CA2517287C/en
Priority to EP18177034.8A priority patent/EP3427741A3/en
Priority to US10/547,371 priority patent/US20060240024A1/en
Application filed by Drew M Pardoll, Ching-Tai Huang, Dario A Vignali, Greg J Workman, Jonathan Powell, Charles C Drake filed Critical Drew M Pardoll
Publication of WO2004078928A2 publication Critical patent/WO2004078928A2/en
Publication of WO2004078928A3 publication Critical patent/WO2004078928A3/en
Priority to US12/578,887 priority patent/US8551481B2/en
Priority to US13/679,485 priority patent/US9005629B2/en
Priority to US14/105,293 priority patent/US20140127226A1/en
Priority to US14/973,806 priority patent/US10787513B2/en
Priority to US15/942,168 priority patent/US10934354B2/en
Priority to US17/155,228 priority patent/US20210230275A1/en
Priority to US18/206,552 priority patent/US20240174747A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
PCT/US2004/006133 2003-02-28 2004-03-01 T cell regulation WO2004078928A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP07021595.9A EP1897548B2 (en) 2003-02-28 2004-03-01 T cell regulation
AU2004217526A AU2004217526B2 (en) 2003-02-28 2004-03-01 T cell regulation
EP04716126A EP1596871A4 (en) 2003-02-28 2004-03-01 T cell regulation
JP2006508934A JP2006523226A (en) 2003-02-28 2004-03-01 T cell regulation method
CA2517287A CA2517287C (en) 2003-02-28 2004-03-01 Regulation of t cells by lag-3 (cd223)
EP18177034.8A EP3427741A3 (en) 2003-02-28 2004-03-01 T cell regulation
US10/547,371 US20060240024A1 (en) 2003-02-28 2004-03-01 T cell regulation
US12/578,887 US8551481B2 (en) 2003-02-28 2009-10-22 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody
US13/679,485 US9005629B2 (en) 2003-02-28 2012-11-16 Method for treating cancer with an antibody to CD223 protein
US14/105,293 US20140127226A1 (en) 2003-02-28 2013-12-13 T Cell Regulation
US14/973,806 US10787513B2 (en) 2003-02-28 2015-12-18 Methods for treatment comprising an antibody that binds CD223 protein
US15/942,168 US10934354B2 (en) 2003-02-28 2018-03-30 Methods of increasing T cell immune response in the treatment of cancer
US17/155,228 US20210230275A1 (en) 2003-02-28 2021-01-22 T cell regulation
US18/206,552 US20240174747A1 (en) 2003-02-28 2023-06-06 T cell regulation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45103903P 2003-02-28 2003-02-28
US60/451,039 2003-02-28
US48214303P 2003-06-24 2003-06-24
US60/482,143 2003-06-24
US53170403P 2003-12-22 2003-12-22
US60/531,704 2003-12-22

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10547371 A-371-Of-International 2004-03-01
US10/547,371 A-371-Of-International US20060240024A1 (en) 2003-02-28 2004-03-01 T cell regulation
US12/578,887 Continuation US8551481B2 (en) 2003-02-28 2009-10-22 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody

Publications (2)

Publication Number Publication Date
WO2004078928A2 WO2004078928A2 (en) 2004-09-16
WO2004078928A3 true WO2004078928A3 (en) 2005-06-23

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PCT/US2004/006133 WO2004078928A2 (en) 2003-02-28 2004-03-01 T cell regulation

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