WO2004077014A2 - Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores - Google Patents
Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores Download PDFInfo
- Publication number
- WO2004077014A2 WO2004077014A2 PCT/US2004/004286 US2004004286W WO2004077014A2 WO 2004077014 A2 WO2004077014 A2 WO 2004077014A2 US 2004004286 W US2004004286 W US 2004004286W WO 2004077014 A2 WO2004077014 A2 WO 2004077014A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- target polynucleotide
- multichromophore
- sensor
- sample
- pbp
- Prior art date
Links
- 0 CC(C)(C)c(cc1)ccc1-c1ccc2-c3ccc(C(C)(C)C)cc3C(*)(*)c2c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1ccc2-c3ccc(C(C)(C)C)cc3C(*)(*)c2c1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT04737272T ATE448327T1 (en) | 2003-02-13 | 2004-02-13 | METHODS AND COMPOSITIONS FOR DETECTING AND ANALYZING POLYNUCLEOTIDE BINDING-PROTEIN INTERACTIONS USING LIGHT-COLLECTING MULTICHROMOPHORES |
DE602004024038T DE602004024038D1 (en) | 2003-02-13 | 2004-02-13 | METHOD AND COMPOSITIONS FOR DETECTING AND ANALYZING POLYNUCLEOTIDE BINDING PROTEIN INTERACTIONS USING LIGHT-COLLECTING MULTICHROMOPHORES |
EP04737272A EP1599609B1 (en) | 2003-02-13 | 2004-02-13 | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
CA2515155A CA2515155C (en) | 2003-02-13 | 2004-02-13 | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
JP2006503558A JP4740111B2 (en) | 2003-02-13 | 2004-02-13 | Methods and compositions for detecting and analyzing polynucleotide binding protein interactions using light collecting multichromophores |
DK04737272.7T DK1599609T3 (en) | 2003-02-13 | 2004-02-13 | Methods and Compositions for Detecting and Analyzing Interactions of Polynucleotide-Binding Proteins Using Light-Collecting Multichromophores |
AU2004215006A AU2004215006A1 (en) | 2003-02-13 | 2004-02-13 | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44786003P | 2003-02-13 | 2003-02-13 | |
US60/447,860 | 2003-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004077014A2 true WO2004077014A2 (en) | 2004-09-10 |
WO2004077014A3 WO2004077014A3 (en) | 2005-07-14 |
Family
ID=32927466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/004286 WO2004077014A2 (en) | 2003-02-13 | 2004-02-13 | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
Country Status (11)
Country | Link |
---|---|
US (1) | US8993335B2 (en) |
EP (3) | EP1599609B1 (en) |
JP (1) | JP4740111B2 (en) |
CN (1) | CN1771335A (en) |
AT (1) | ATE448327T1 (en) |
AU (1) | AU2004215006A1 (en) |
CA (1) | CA2515155C (en) |
DE (1) | DE602004024038D1 (en) |
DK (1) | DK1599609T3 (en) |
ES (1) | ES2440920T3 (en) |
WO (1) | WO2004077014A2 (en) |
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WO2005086617A2 (en) | 2003-09-17 | 2005-09-22 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
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US7629448B2 (en) | 2002-08-26 | 2009-12-08 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
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US8993335B2 (en) | 2003-02-13 | 2015-03-31 | The Regents Of The University Of California | Methods for detection and analysis of polynucleotide-binding protein interactions |
US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
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US10001473B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
US10107818B2 (en) | 2006-10-06 | 2018-10-23 | Sirigen Ii Limited | Fluorescent methods and materials for directed biomarker signal amplification |
US10265696B2 (en) | 2012-12-27 | 2019-04-23 | Research Business Foundation Sungkyunkwan University | Nucleic acid amplification disk apparatus using temperature sensitive polymer synthesis and the analysis method using the same |
US10288620B2 (en) | 2010-01-19 | 2019-05-14 | Sirigen Ii Limited | Reagents for directed biomarker signal amplification |
US10408759B2 (en) | 2015-05-26 | 2019-09-10 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
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---|---|---|---|---|
US7297494B2 (en) * | 2001-06-25 | 2007-11-20 | Georgia Tech Research Corporation | Activatable probes and methods for in vivo gene detection |
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Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950587A (en) | 1988-09-02 | 1990-08-21 | Eastman Kodak Company | J-aggregating dye polymers as spectral sensitizers for silver halide photographic compositions |
US5998135A (en) | 1989-02-24 | 1999-12-07 | Enzo Diagnostics, Inc. | Energy transfer hybridization assay using intercalators and lanthanide metals |
US4948843A (en) | 1989-05-30 | 1990-08-14 | Eastman Kodak Company | Dye polymer/sol-gel composites |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5763162A (en) | 1990-03-14 | 1998-06-09 | The Regents Of University Of California | Multichromophore fluorescent DNA intercalation complexes |
DE69132531T2 (en) | 1990-12-06 | 2001-09-13 | Affymetrix Inc | Compounds and their use in a binary synthesis strategy |
US5408109A (en) | 1991-02-27 | 1995-04-18 | The Regents Of The University Of California | Visible light emitting diodes fabricated from soluble semiconducting polymers |
WO1993009668A1 (en) | 1991-11-22 | 1993-05-27 | Affymax Technology N.V. | Combinatorial strategies for polymer synthesis |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5536820A (en) | 1993-02-26 | 1996-07-16 | E. I. Du Pont De Nemours And Company | Avidin-binding azo reagents |
ES2259791T3 (en) | 1993-07-13 | 2006-10-16 | Abbott Laboratories | VERY FLUORESCENT CONJUGATES OF POLYMERS AND INTERMEDIATES. |
EP0684239B1 (en) | 1994-05-26 | 2003-12-10 | Canon Kabushiki Kaisha | A method for detecting a target substance in a sample, utilizing pyrylium compound |
US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
ES2213899T3 (en) | 1997-04-29 | 2004-09-01 | Amersham Health As | CONTRAST AGENTS USED IN IMAGE FORMATION TECHNIQUES BASED ON LIGHT. |
US5881083A (en) | 1997-07-03 | 1999-03-09 | The Regents Of The University Of California | Conjugated polymers as materials for solid state laser |
US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
JP2002508935A (en) | 1998-01-09 | 2002-03-26 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Enzyme-specific cleavable polynucleotide substrates and assay methods |
ATE239801T1 (en) * | 1998-01-22 | 2003-05-15 | Luminex Corp | MICROPARTICLES WITH MULTIPLE FLUORESCENCE SIGNALS |
US5968762A (en) | 1998-03-19 | 1999-10-19 | The University Of Connecticut | Method for detecting bacteria in a sample |
JP2000019171A (en) * | 1998-04-28 | 2000-01-21 | Kazuko Matsumoto | Analysis method by labeled probe |
EP1281744B1 (en) | 1998-05-05 | 2008-09-24 | Massachusetts Institute Of Technology | Emissive polymers and devices incorporating these polymers |
ATE409215T1 (en) | 1998-05-05 | 2008-10-15 | Massachusetts Inst Technology | EMITTING POLYMERS AND DEVICES CONTAINING THESE POLYMERS |
US6263286B1 (en) | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
GB9819417D0 (en) | 1998-09-07 | 1998-10-28 | Secr Defence | Reaction method |
DE69905832T2 (en) | 1998-09-18 | 2004-02-05 | Massachusetts Institute Of Technology, Cambridge | Biological uses of semiconducting nanocrystals |
US6951682B1 (en) | 1998-12-01 | 2005-10-04 | Syntrix Biochip, Inc. | Porous coatings bearing ligand arrays and use thereof |
US6541671B1 (en) | 2002-02-13 | 2003-04-01 | The Regents Of The University Of California | Synthesis of 2H- and 13C-substituted dithanes |
US6589731B1 (en) | 1999-05-05 | 2003-07-08 | The Regents Of The University Of California | Method for detecting biological agents |
WO2001001144A2 (en) | 1999-06-30 | 2001-01-04 | Iris Bio Technologies | Hybridization of target dna with immobilized nucleic acid analogs |
US6579726B1 (en) | 1999-07-30 | 2003-06-17 | Surromed, Inc. | Instruments, methods and reagents for surface plasmon resonance |
WO2003074738A1 (en) | 2000-01-18 | 2003-09-12 | Quantom Dot Corporation | Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization |
US6984528B2 (en) | 2000-03-20 | 2006-01-10 | Analytical Biological Services Inc. | Method for detecting an analyte by fluorescence |
JP2004500109A (en) | 2000-03-22 | 2004-01-08 | クァンタム・ドット・コーポレイション | Use of semiconductor nanocrystals in bead-based nucleic acid assays |
EP1301626A4 (en) | 2000-05-08 | 2004-06-02 | Qtl Biosystems Llc | Improvements to the fluorescent polymer-qtl approach to biosensing |
AU2001275213A1 (en) | 2000-06-06 | 2001-12-17 | Dna Sciences, Inc. | A method and system for populating a database |
US20020177136A1 (en) | 2000-08-23 | 2002-11-28 | Mcbranch Duncan W. | Peptide nucleic acid based molecular sensors for nucleic acids |
JP2005507489A (en) * | 2001-02-23 | 2005-03-17 | ジェニコン サイエンスィズ コーポレーション | How to provide extended dynamic range in sample analysis |
JP2004527746A (en) | 2001-03-16 | 2004-09-09 | キューティエル・バイオシステムズ・リミテッド・ライアビリティ・カンパニー | Bioassay based on fluorescent polymer superquenching |
CA2442860C (en) | 2001-04-05 | 2011-02-01 | Mario Leclerc | Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives |
WO2002084271A2 (en) | 2001-04-16 | 2002-10-24 | The Regents Of The University Of California | Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides |
KR20040083411A (en) | 2001-08-23 | 2004-10-01 | 큐티엘 바이오시스템즈 엘엘씨 | Bio-sensing platforms for detection and quantitation of biological molecules |
DE10153829A1 (en) | 2001-11-05 | 2003-05-28 | Bayer Ag | Assay based on doped nanoparticles |
CA2462617A1 (en) | 2001-11-07 | 2003-05-15 | Sensor Technologies Llc | Method of identifying energy transfer sensors for analytes |
US20040023248A1 (en) | 2001-12-07 | 2004-02-05 | Whitehead Institiute For Biomedical Research | Methods and reagents for improving nucleic acid detection |
US6808542B2 (en) | 2001-12-26 | 2004-10-26 | American Dye Source, Inc. | Photoluminescent markers and methods for detection of such markers |
WO2003091701A2 (en) | 2002-03-29 | 2003-11-06 | Board Of Regents Of The University Of Texas System | Implantable biosensor from stratified nanostructured membranes |
EP1495139A4 (en) | 2002-03-29 | 2006-06-28 | Genentech Inc | Methods and compositions for detection and quantitation of nucleic acid analytes |
JP4457001B2 (en) | 2002-05-31 | 2010-04-28 | セクレタリー・デパートメント・オブ・アトミック・エナジー | MET / FRET based method for target nucleic acid detection in which donor / acceptor moieties are on complementary strands |
EP1534857B1 (en) * | 2002-06-20 | 2010-08-04 | The Regents of The University of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
CA2497152C (en) | 2002-08-26 | 2016-06-07 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
SG111090A1 (en) | 2002-10-25 | 2005-05-30 | Agency Science Tech & Res | Cationic water-soluble conjugated polymers and their precursors |
CA2510180C (en) * | 2002-12-17 | 2012-09-11 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
US20040121337A1 (en) | 2002-12-19 | 2004-06-24 | Nomadics, Inc. | Luminescent polymers and methods of use thereof |
CA2515155C (en) | 2003-02-13 | 2013-11-19 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
JP3912393B2 (en) | 2003-08-08 | 2007-05-09 | セイコーエプソン株式会社 | Method for manufacturing organic electroluminescence device |
WO2005056628A2 (en) | 2003-09-17 | 2005-06-23 | The Regents Of The University Of California | Methods and devices comprising soluble conjugated polymers |
US7141437B2 (en) | 2003-11-13 | 2006-11-28 | Michigan Molecular Institute | Solid-state colorimetric biosensors comprised of dendritic polymer networks |
WO2005073338A2 (en) | 2003-12-04 | 2005-08-11 | Massachusetts Institute Of Technology | Fluorescent, semi-conductive polymers, and devices comprising them |
US7759127B2 (en) | 2003-12-05 | 2010-07-20 | Massachusetts Institute Of Technology | Organic materials able to detect analytes |
EP1692309A4 (en) | 2003-12-12 | 2007-10-24 | Infectio Recherche Inc | System for charge-based detection of nucleic acids |
SE0401219D0 (en) | 2004-05-10 | 2004-05-10 | Biochromix Ab | Methods for detecting conformational changes or aggregation of proteins by conjugated polyelectrolytes |
US8617819B2 (en) | 2004-09-17 | 2013-12-31 | Massachusetts Institute Of Technology | Polymers for analyte detection |
WO2007001438A2 (en) | 2004-10-29 | 2007-01-04 | Molecular Probes, Inc. | Functionalized fluorescent nanocrystals, and methods for their preparation and use |
CA2594458C (en) | 2005-01-10 | 2016-08-23 | The Regents Of The University Of California | Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
US7811755B2 (en) | 2005-01-10 | 2010-10-12 | The Regents Of The University Of California | Methods and articles for strand-specific polynucleotide detection with cationic multichromophores |
ATE458835T1 (en) | 2005-03-03 | 2010-03-15 | Ca Nat Research Council | METHODS AND COMPOSITIONS FOR DETECTING AND ANALYZING NUCLEIC ACIDS USING SIGNAL AMPLIFICATION |
JP2016031772A (en) | 2014-07-30 | 2016-03-07 | 株式会社日立ハイテクファインシステムズ | Inspection method and apparatus of heat-assisted magnetic head element |
-
2004
- 2004-02-13 CA CA2515155A patent/CA2515155C/en not_active Expired - Lifetime
- 2004-02-13 DE DE602004024038T patent/DE602004024038D1/en not_active Expired - Lifetime
- 2004-02-13 EP EP04737272A patent/EP1599609B1/en not_active Expired - Lifetime
- 2004-02-13 DK DK04737272.7T patent/DK1599609T3/en active
- 2004-02-13 ES ES09175515.7T patent/ES2440920T3/en not_active Expired - Lifetime
- 2004-02-13 AT AT04737272T patent/ATE448327T1/en not_active IP Right Cessation
- 2004-02-13 WO PCT/US2004/004286 patent/WO2004077014A2/en active Application Filing
- 2004-02-13 EP EP09175515.7A patent/EP2161343B1/en not_active Expired - Lifetime
- 2004-02-13 JP JP2006503558A patent/JP4740111B2/en not_active Expired - Lifetime
- 2004-02-13 CN CNA2004800096314A patent/CN1771335A/en active Pending
- 2004-02-13 AU AU2004215006A patent/AU2004215006A1/en not_active Abandoned
- 2004-02-13 US US10/779,412 patent/US8993335B2/en active Active
- 2004-02-13 EP EP10185501A patent/EP2351856A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of EP1599609A4 * |
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US11732138B2 (en) | 2017-12-26 | 2023-08-22 | Becton, Dickinson And Company | Deep ultraviolet-excitable water-solvated polymeric dyes |
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US8993335B2 (en) | 2015-03-31 |
EP1599609B1 (en) | 2009-11-11 |
US20050003386A1 (en) | 2005-01-06 |
EP2161343A1 (en) | 2010-03-10 |
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CA2515155A1 (en) | 2004-09-10 |
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