WO2004066876A1 - Improved packaging for stent delivery systems - Google Patents
Improved packaging for stent delivery systems Download PDFInfo
- Publication number
- WO2004066876A1 WO2004066876A1 PCT/IE2003/000013 IE0300013W WO2004066876A1 WO 2004066876 A1 WO2004066876 A1 WO 2004066876A1 IE 0300013 W IE0300013 W IE 0300013W WO 2004066876 A1 WO2004066876 A1 WO 2004066876A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- package
- stent
- compartments
- compartment
- breathable membrane
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/081—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/002—Packages specially adapted therefor ; catheter kit packages
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
- A61B2050/314—Flexible bags or pouches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
Definitions
- the present invention relates to a method of packaging and a packaging system for stent delivery systems which minimise the level of exposure of the stents to oxygen, moisture and light.
- Cardiovascular disease including atherosclerosis, is the leading cause of death in the U.S.
- a number of methods and devices for treating coronary heart disease have been developed, some of which are specifically designed to treat the complications resulting from atherosclerosis and other forms of coronary arterial narrowing.
- angioplasty percutaneous transluminal coronary angioplasty
- the objective in angioplasty is to enlarge the lumen of the affected coronary artery by radial expansion. This is generally accomplished by inflating a balloon within the narrowed lumen of the affected artery. The wall of the artery itself may also be stretched as the balloon is inflated. With simple angioplasty, the balloon is threaded through the artery with a catheter and inflated at the place where the blood vessel is blocked. After the procedure, the balloon is then removed. With simply angioplasty alone, arteries may close up again or re-narrow. This narrowing is known as restenosis.
- a stent may also be inserted during angioplasty.
- a stent is a tube, often made of metals or occasionally plastic materials that is inserted into a vessel or a passage in the body to keep the lumen of the vessel open and to prevent closure due to a stricture or external compression.
- the use of a stent may reduce the risk of restenosis.
- stent insertion can cause undesirable reactions such as inflammation, infection, thrombosis, or proliferation of cell growth that occludes the passageway.
- Restenosis occurs because the blood vessel wall is injured when the stent is implanted. The area then becomes inflated and new cells form scar tissue. The arterial walls may become so thick in some instances that they sometimes protrude into the mesh of the stent. In such cases, a further angioplasty may be undergone, and a new stent may be placed inside the existing one. If restenosis continues, the eventual alternative may be bypass surgery.
- a treated stent maybe inserted during the angioplasty.
- a treated stent may eliminate the need for repeat angioplasties and could spare some patients the trauma, risk and prolonged recovery associated with heart bypass surgery.
- the treated stent contains a therapeutic agent to assist in preventing restenosis.
- the stent is bioengineered to release doses of the therapeutic agent which may or may not be contained in a coating on the stent.
- Agents contemplated act to stop new cells from forming without impairing the healing of the vessel. Agents may also dampen inflammation and have antibiotic properties.
- treated stents may contain a therapeutic drug
- treated stents present problems associated with drug administration. For example, for a drug to be administered effectively, the integrity of the drug's effective dosage should be maintained. Certain drugs require regulated conditions for efficacy, such as regulated air circulation or lack thereof, regulated exposure to light and oxygen.
- thermoform tray inserts in a foil pouch, or a thermoform tray having a Tyvek ® lid in a foil pouch, into which the stent is vacuum packed.
- thermoform tray inserts do not provide for regulation of ambient conditions such as circulation of air or exposure to light and oxygen. Without such appropriate regulation, the efficacy of the drug and/or drug coating maybe reduced.
- these packages tend to be heavier than those of the present invention, they utilise more material and they require more operator handling time to pack and so are more labour intensive to produce.
- EtO ethylene oxide
- the package comprises at least one outer wall and an inner wall, the inner wall being formed from the breathable membrane.
- the breathable membrane suitably provides a barrier to microbes but allows the passage of air and other gases and moisture.
- One suitable material is TyvekTM, and another is paper.
- the package comprises two outer walls and one internal wall.
- the outer walls may be made of a plastics-coated foil and the internal wall may be made of the breathable membrane.
- the outer walls may further comprise an outer layer of a peelable material.
- the internal wall may be attached to one outer wall adjacent its outer edge, to form a pocket open at one end.
- the internal wall is smaller than the outer wall so that one compartment is smaller than the other. This has the advantage that the package uses as little breathable membrane as possible.
- both compartments may be sealed in a single operation.
- the sealed package may then be sterilised by gamma radiation in a conventional manner.
- one outer wall may comprise foil over only a portion of its surface such that an area of the breathable membrane is exposed.
- This embodiment is suitable for sterilisation of the contents by ethylene oxide gas since the exposed membrane provides an entry and exit for the sterilant gas.
- the stent is sealed in the compartment and then the package is sterilised with ethylene oxide.
- at least one moisture or oxygen scavenger pack is placed in the second of the two compartments.
- the package is then flushed with an inert gas and a vacuum is applied to the package. Following vacuum draw down the package is sealed across all three layers of the pouch to seal the second compartment closed. Excess pouch material, between the first and second seals may then be cut away.
- One compartment of the package is thus adapted to hold an oxygen absorber pack or a moisture absorber pack or both.
- the scavenger packs are not placed in the package until after ethylene oxide sterilisation to prevent the absorber packs being saturated by the sterilisation process.
- One corner of the package, remote from the sealed end is provided with a peel seal which allows the package to be opened. By providing the peel seal at a position remote from the edge which seals the package closed, the package can be torn open to remove the stent without breaching the absorber pack compartment.
- edges of the package which are to be sealed together may be coated with an easy peel adhesive, which would show a mark on opening if the seal had not been intact in any given area.
- the inert gas used to flush the package is preferably nitrogen.
- the package may be sealed by clamping the edges of the package between upper and lower jaws of a sealing device.
- the package is particularly adapted to house a stent and its associated delivery systems, but would also be suitable for use in any application where moisture, oxygen and/or light exposure must be minimised.
- the provision of two compartments allows interaction of the scavenger packs with the treated stent, but without any physical contact.
- Figure 1 shows a first package configuration in accordance with the invention, suitable for sterilisation with gamma radiation, with the treated stent and absorber packs in place,
- Figure 2 shows an alternative package configuration in accordance with the invention, suitable for sterilisation with ethylene oxide, with the treated stent sealed in one compartment,
- Figure 3 shows the embodiment of Figure 2 with the treated stent and absorber packs in place
- FIG. 4 shows a package being torn open to remove the treated stent.
- the packaging for a treated stent delivery system takes the form of a pouch or bag (1), as shown in Figure 1.
- the pouch (1) is provided with two compartments (2,3).
- the compartments are formed by sealing a sheet of impermeable membrane (4) such as Tyvek ® material, to a layer of laminated foil (5) and then sealing the two layers of laminated foil (5) together.
- the sheet (4) is shorter than layers (5) but of the same width, so that the sheet (4) is sealed along the line (6) and its side edges to layer (5). This means that the two compartments are of different sizes and is less wasteful of materials.
- Tyvek® material is commercially available from DuPont and consists of multiple spun woven extruded polyethylene strands, compressed under high pressure to form a complex system of microscopic porous channels which provides a tortuous porous path within a thin flexible opaque sheet.
- Other breathable membranes, such as paper, that suitably provide a barrier to microbes but allow the passage of air and other gases and moisture could also be used.
- Tyvek® material has the advantage of having greater tear strength than paper and so is less likely to tear on application of the vacuum.
- One compartment (2) is adapted to contain oxygen and moisture absorber packs (7,8). Suitable oxygen and moisture absorber packs are commercially available from Mitsubishi Gas chemical company, Inc./(Pharmakeep KD-20TM), and Silgel Ltd./(4g Molecular Sieve sachets), respectively.
- the other compartment (3) is adapted to contain the treated stent (9). This compartment is larger than compartment (2). Forming the compartments with one wall made of Tyvek allows the absorber packs (7,8) to interact with the coated stent delivery system (9) but at the same time prevents direct contact between the absorber packs and the delivery system. The advantage of not putting the moisture absorber packs into direct contact with the delivery system is that there is a possibility that tiny amounts of content residue would be present on the outside of each pack, and this residue would adversely interact with the drug coating.
- Example 1 The process for packaging a stent which is sterilised by gamma radiation comprises placing a coated stent , mounted on a delivery system and loaded into a coiled dispenser, into the larger of the two compartments of the pouch.
- the compartment is 280 mm long and 250 mm wide.
- the layer of Tyvek is located between two layers of foil, which are both of equal length, so that no portion of the Tyvek is exposed.
- the moisture and oxygen absorber packs are placed in the second compartment which is 120mm long.
- the Tyvek layer thus separates the scavenger packs from the stent but allows interaction between the two compartments.
- the open end of the pouch is flushed with nitrogen and vacuum-sealed, so that the two compartments are sealed together. Any excess material above the seal area is trimmed away, which eliminates the possibility of opening the pouch at this end.
- the inert gas used to flush the package is preferably nitrogen.
- the nitrogen is flushed for between 1 and 10 seconds at a pressure of 10 to 30psi..
- the vacuum draw down time is suitably 1 second, up to 10 seconds.
- the package may be sealed by clamping the edges of the package between upper an l lower jaws of a sealing device.
- the seal time may be from 1 to 10 seconds, with an upper jaw seal temperature of 110 to 200 °C and a lower jaw seal temperature of 60 to 100 ° C and the seal pressure may be
- the sealed pouch is then sterilised by gamma radiation in a conventional manner.
- the process for packaging a stent which is sterilised by ethylene oxide is slightly different.
- the coated stent (9) mounted on a delivery system and loaded onto a coiled dispenser, is placed in the larger of the two compartments (3).
- the compartment (3) is 365mm long.
- One of the two foil sheets (5) is shorter than the Tyvek layer (4) and the other foil sheet (5), so that a section of the Tyvek is exposed on the surface of the package (1).
- This exposed area (10) provides an entry and exit point for the ethylene oxide gas in the sterilisation process.
- the compartment (3) is then sealed at its open end, along the line (11) shown in Figure 3, with a heated bar sealer as described in Example 1. Because one foil sheet (5) is shorter than the other it is not sealed in this operation and so one compartment (2) is left open at one end.
- the package is then sterilised using ethylene oxide in a conventional manner.
- oxygen and moisture absorber (7,8) packs are placed in the smaller, unsealed compartment (2) of the pouch or package (1).
- This compartment is 145mm long.
- the package (1) is then flushed with nitrogen and vacuum-sealed, as described above, across the opening of the scavenger pack compartment (2) along the line (12). Excess pouch material between the two seal lines (10) and (12) is then trimmed away, which eliminates the possibility of opening the pouch (1) at this end which could result in the scavenger packs being released and contaminating the stent.
- Figure 4 shows the package (1) being opened at one end to remove the stent, and the absorber packs (7,8) being retained in compartment (2).
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Mechanical Engineering (AREA)
- Pulmonology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Packages (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IE2003/000013 WO2004066876A1 (en) | 2003-01-27 | 2003-01-27 | Improved packaging for stent delivery systems |
EP03700986A EP1589902A1 (en) | 2003-01-27 | 2003-01-27 | Improved packaging for stent delivery systems |
US10/543,477 US7762044B2 (en) | 2003-01-27 | 2003-01-27 | Packaging for stent delivery systems |
US12/796,285 US8297439B2 (en) | 2003-01-27 | 2010-06-08 | Packaging for a stent delivery system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IE2003/000013 WO2004066876A1 (en) | 2003-01-27 | 2003-01-27 | Improved packaging for stent delivery systems |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/543,477 A-371-Of-International US7762044B2 (en) | 2003-01-27 | 2003-01-27 | Packaging for stent delivery systems |
US12/796,285 Division US8297439B2 (en) | 2003-01-27 | 2010-06-08 | Packaging for a stent delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004066876A1 true WO2004066876A1 (en) | 2004-08-12 |
Family
ID=32800547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IE2003/000013 WO2004066876A1 (en) | 2003-01-27 | 2003-01-27 | Improved packaging for stent delivery systems |
Country Status (3)
Country | Link |
---|---|
US (2) | US7762044B2 (en) |
EP (1) | EP1589902A1 (en) |
WO (1) | WO2004066876A1 (en) |
Cited By (93)
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WO2006008651A1 (en) * | 2004-07-16 | 2006-01-26 | Pfizer Products Inc. | Pharmaceutical package for simultaneously maintaining low moisture and low oxygen levels |
EP1867298A1 (en) * | 2005-04-07 | 2007-12-19 | Terumo Kabushiki Kaisha | Drug-eluting stent system and method of producing drug-eluting stent system |
WO2009009635A1 (en) * | 2007-07-10 | 2009-01-15 | Boston Scientific Limited | Stent protector |
US7631760B2 (en) | 2008-02-07 | 2009-12-15 | Amcor Flexibles Healthcare, Inc. | Dual compartment pouch |
US7824443B2 (en) | 2003-12-23 | 2010-11-02 | Sadra Medical, Inc. | Medical implant delivery and deployment tool |
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EP2322230A1 (en) * | 2009-11-16 | 2011-05-18 | Cordis Corporation | Electron beam sterilization of medical devices |
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US20060260967A1 (en) | 2006-11-23 |
US7762044B2 (en) | 2010-07-27 |
US8297439B2 (en) | 2012-10-30 |
EP1589902A1 (en) | 2005-11-02 |
US20100264050A1 (en) | 2010-10-21 |
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