WO2004064824A1 - Utilisation de derives d'acide hydroxamique pour la preparation de medicaments antitumoraux - Google Patents

Utilisation de derives d'acide hydroxamique pour la preparation de medicaments antitumoraux Download PDF

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Publication number
WO2004064824A1
WO2004064824A1 PCT/EP2003/014171 EP0314171W WO2004064824A1 WO 2004064824 A1 WO2004064824 A1 WO 2004064824A1 EP 0314171 W EP0314171 W EP 0314171W WO 2004064824 A1 WO2004064824 A1 WO 2004064824A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
group
phenyl
hydrogen
amino
Prior art date
Application number
PCT/EP2003/014171
Other languages
English (en)
Inventor
Flavio Leoni
Paolo Mascagni
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to AU2003290034A priority Critical patent/AU2003290034A1/en
Priority to JP2004566776A priority patent/JP4495599B2/ja
Priority to EP03782390A priority patent/EP1583523B1/fr
Priority to US10/542,244 priority patent/US8227515B2/en
Priority to DE60311888T priority patent/DE60311888T2/de
Publication of WO2004064824A1 publication Critical patent/WO2004064824A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne l'utilisation de dérivés d'acide hydroxamique contenant une fraction amidobenzoïque pour la préparation de médicaments antitumoraux.
PCT/EP2003/014171 2003-01-17 2003-12-10 Utilisation de derives d'acide hydroxamique pour la preparation de medicaments antitumoraux WO2004064824A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003290034A AU2003290034A1 (en) 2003-01-17 2003-12-10 Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments
JP2004566776A JP4495599B2 (ja) 2003-01-17 2003-12-10 抗腫瘍薬の調製のためにヒドロキサム酸誘導体を使用する方法
EP03782390A EP1583523B1 (fr) 2003-01-17 2003-12-10 Utilisation de derives d'acide hydroxamique pour la preparation de medicaments antitumoraux
US10/542,244 US8227515B2 (en) 2003-01-17 2003-12-10 Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments
DE60311888T DE60311888T2 (de) 2003-01-17 2003-12-10 Verwendung von hydroxamsäurederivaten zur herstellung von antitumorarzneimitteln

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2003A000064 2003-01-17
IT000064A ITMI20030064A1 (it) 2003-01-17 2003-01-17 Uso dei derivati dell'acido idrossamico per la preparazione

Publications (1)

Publication Number Publication Date
WO2004064824A1 true WO2004064824A1 (fr) 2004-08-05

Family

ID=32750476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/014171 WO2004064824A1 (fr) 2003-01-17 2003-12-10 Utilisation de derives d'acide hydroxamique pour la preparation de medicaments antitumoraux

Country Status (8)

Country Link
US (1) US8227515B2 (fr)
EP (1) EP1583523B1 (fr)
JP (1) JP4495599B2 (fr)
AU (1) AU2003290034A1 (fr)
DE (1) DE60311888T2 (fr)
ES (1) ES2282705T3 (fr)
IT (1) ITMI20030064A1 (fr)
WO (1) WO2004064824A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2344253A1 (fr) * 2008-09-29 2011-07-20 Italfarmaco SpA Utilisation d'inhibiteurs d'histone désacétylases pour soigner des syndromes myéloprolifératifs philadelphie-négatifs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901465A1 (fr) * 1996-05-14 1999-03-17 ITALFARMACO S.p.A. Composes a activites anti-inflammatoire et immunosuppressive
WO2001038322A1 (fr) * 1999-11-23 2001-05-31 Methylgene, Inc. Inhibiteurs de l'histone deacetylase
WO2002074298A1 (fr) * 2001-03-21 2002-09-26 Ono Pharmaceutical Co., Ltd. Inhibiteurs de production d'il-6
WO2003013493A1 (fr) * 2001-08-07 2003-02-20 Italfarmaco S.P.A. Derives de l'acide hydroxamique inhibiteurs de l'enzyme histone deacetylase utilises comme nouveaux medicaments anti-inflammatoires inhibiteurs de la synthese de la cytokine
WO2003070691A1 (fr) * 2002-02-21 2003-08-28 Osaka Industrial Promotion Organization Derive de n-hydroxycarboxamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101257D0 (sv) * 2001-04-06 2001-04-06 A & Science Invest Ab Treatment of whiplash associated disorder

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901465A1 (fr) * 1996-05-14 1999-03-17 ITALFARMACO S.p.A. Composes a activites anti-inflammatoire et immunosuppressive
WO2001038322A1 (fr) * 1999-11-23 2001-05-31 Methylgene, Inc. Inhibiteurs de l'histone deacetylase
WO2002074298A1 (fr) * 2001-03-21 2002-09-26 Ono Pharmaceutical Co., Ltd. Inhibiteurs de production d'il-6
WO2003013493A1 (fr) * 2001-08-07 2003-02-20 Italfarmaco S.P.A. Derives de l'acide hydroxamique inhibiteurs de l'enzyme histone deacetylase utilises comme nouveaux medicaments anti-inflammatoires inhibiteurs de la synthese de la cytokine
WO2003070691A1 (fr) * 2002-02-21 2003-08-28 Osaka Industrial Promotion Organization Derive de n-hydroxycarboxamide

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NAKA, MASAO ET AL: "Preparation of N-acylaminoalkanehydroxamic acids as IL-6 production inhibitors", XP002276409, retrieved from STN Database accession no. 137:247516 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; UESATO, SHINICHI ET AL: "Preparation of N-hydroxycarboxamide derivatives as anticancer agents", XP002276410, retrieved from STN Database accession no. 139:214215 *
JUNG, MANFRED ET AL: "Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase an Inducers of Terminal Cell Differentiation", JOURNAL OF MEDICINAL CHEMISTRY (1999), 42(22), 4669-4679, XP002144226 *
NICOLAUS B J R: "Symbiotic Approach to Drug Design", DECISION MAKING IN DRUG RESEARCH, XX, XX, 1983, pages 173 - 186, XP002197412 *
UESATO, SHINICHI ET AL: "Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002), 12(10), 1347-1349, XP002276408 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2344253A1 (fr) * 2008-09-29 2011-07-20 Italfarmaco SpA Utilisation d'inhibiteurs d'histone désacétylases pour soigner des syndromes myéloprolifératifs philadelphie-négatifs
EP2344253B1 (fr) * 2008-09-29 2014-04-23 Italfarmaco SpA Utilisation d'inhibiteurs d'histone désacétylases pour soigner des syndromes myéloprolifératifs philadelphie-négatifs

Also Published As

Publication number Publication date
AU2003290034A1 (en) 2004-08-13
EP1583523B1 (fr) 2007-02-14
US20060063800A1 (en) 2006-03-23
EP1583523A1 (fr) 2005-10-12
ES2282705T3 (es) 2007-10-16
ITMI20030064A1 (it) 2004-07-18
DE60311888D1 (de) 2007-03-29
DE60311888T2 (de) 2007-12-06
US8227515B2 (en) 2012-07-24
JP2006514659A (ja) 2006-05-11
JP4495599B2 (ja) 2010-07-07

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