WO2004047769A3 - Benzimidazoles and analogs thereof as antibacterials - Google Patents

Benzimidazoles and analogs thereof as antibacterials Download PDF

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Publication number
WO2004047769A3
WO2004047769A3 PCT/US2003/038093 US0338093W WO2004047769A3 WO 2004047769 A3 WO2004047769 A3 WO 2004047769A3 US 0338093 W US0338093 W US 0338093W WO 2004047769 A3 WO2004047769 A3 WO 2004047769A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzimidazoles
antibacterials
analogs
piperidines
benzimidazolyl
Prior art date
Application number
PCT/US2003/038093
Other languages
French (fr)
Other versions
WO2004047769A2 (en
Inventor
Yun He
Eric E Swayze
Punit P Seth
Elizabeth Anne Jefferson
Original Assignee
Isis Pharmaceuticals Inc
Yun He
Eric E Swayze
Punit P Seth
Elizabeth Anne Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Yun He, Eric E Swayze, Punit P Seth, Elizabeth Anne Jefferson filed Critical Isis Pharmaceuticals Inc
Priority to AU2003297597A priority Critical patent/AU2003297597A1/en
Publication of WO2004047769A2 publication Critical patent/WO2004047769A2/en
Publication of WO2004047769A3 publication Critical patent/WO2004047769A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Abstract

The invention is drawn to indolyl piperidines, benzimidazolyl piperidines, benzimidazolyl dimer and pyridylindolyl piperidines which have antibacterial actibities.
PCT/US2003/038093 2002-11-26 2003-11-26 Benzimidazoles and analogs thereof as antibacterials WO2004047769A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003297597A AU2003297597A1 (en) 2002-11-26 2003-11-26 Benzimidazoles and analogs thereof as antibacterials

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42959502P 2002-11-26 2002-11-26
US60/429,595 2002-11-26
US43049502P 2002-12-03 2002-12-03
US60/430,495 2002-12-03

Publications (2)

Publication Number Publication Date
WO2004047769A2 WO2004047769A2 (en) 2004-06-10
WO2004047769A3 true WO2004047769A3 (en) 2004-09-10

Family

ID=32397209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038093 WO2004047769A2 (en) 2002-11-26 2003-11-26 Benzimidazoles and analogs thereof as antibacterials

Country Status (2)

Country Link
AU (1) AU2003297597A1 (en)
WO (1) WO2004047769A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
CN101397276B (en) * 2007-09-29 2012-10-03 西南大学 Dibenzimidazole and onium compound thereof, preparation method and medical use thereof
WO2010144686A1 (en) * 2009-06-10 2010-12-16 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
US10292390B2 (en) 2011-11-04 2019-05-21 Wisconsin Alumni Research Foundation Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives
CN104610150A (en) * 2015-02-13 2015-05-13 佛山市赛维斯医药科技有限公司 Compound containing hydrazide and cyanobenzene structures as well as preparation method and application thereof
GB201700587D0 (en) 2017-01-13 2017-03-01 Redag Crop Prot Ltd Agricultural chemicals
WO2022266711A1 (en) * 2021-06-23 2022-12-29 Aculeus Therapeutics Pty Ltd Substituted amidobenzimidazole dimers as sting modulators
CN114560813B (en) * 2022-03-07 2023-09-12 南京中医药大学 Benzimidazole MK2 allosteric inhibitor and preparation method and application thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3017415A (en) * 1960-01-18 1962-01-16 Merck & Co Inc Certain benzimidazoles carrying thiazolyl, thiadiazolyl and isothiazolyl substituents in the 2 position
GB966796A (en) * 1960-05-04 1964-08-19 Merck & Co Inc Compositions containing substituted benzimidazoles
DE2259345A1 (en) * 1972-12-04 1974-06-06 Siemens Ag METHODS FOR CLEANING NUCLEAR POWER PLANTS
US3864350A (en) * 1974-03-18 1975-02-04 Squibb & Sons Inc Pridyl-1H-benzimidazole N-oxides
EP0058975A1 (en) * 1981-02-25 1982-09-01 Boehringer Ingelheim Pharmaceuticals Inc. Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
WO2000001676A1 (en) * 1998-07-02 2000-01-13 Neurosearch A/S Potassium channel blocking agents
WO2001081310A1 (en) * 2000-04-27 2001-11-01 Aventis Pharmaceuticals Inc. 1-aroyl-piperidinyl benzamidines
WO2002036589A1 (en) * 2000-10-31 2002-05-10 Almirall Prodesfarma S.A. Indolylpiperidine derivatives as antihistaminic and antiallergic agents

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3017415A (en) * 1960-01-18 1962-01-16 Merck & Co Inc Certain benzimidazoles carrying thiazolyl, thiadiazolyl and isothiazolyl substituents in the 2 position
GB966796A (en) * 1960-05-04 1964-08-19 Merck & Co Inc Compositions containing substituted benzimidazoles
DE2259345A1 (en) * 1972-12-04 1974-06-06 Siemens Ag METHODS FOR CLEANING NUCLEAR POWER PLANTS
US3864350A (en) * 1974-03-18 1975-02-04 Squibb & Sons Inc Pridyl-1H-benzimidazole N-oxides
EP0058975A1 (en) * 1981-02-25 1982-09-01 Boehringer Ingelheim Pharmaceuticals Inc. Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
WO2000001676A1 (en) * 1998-07-02 2000-01-13 Neurosearch A/S Potassium channel blocking agents
WO2001081310A1 (en) * 2000-04-27 2001-11-01 Aventis Pharmaceuticals Inc. 1-aroyl-piperidinyl benzamidines
WO2002036589A1 (en) * 2000-10-31 2002-05-10 Almirall Prodesfarma S.A. Indolylpiperidine derivatives as antihistaminic and antiallergic agents

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] 1 November 2001 (2001-11-01), AVENTIS PHARMACEUTICALS PRODUCTS INC., USA: "Preparation of 1-aroyl-piperidinyl benzamines as inhibitors of Factor Xa or tryptase", XP002978638, accession no. STN Database accession no. 2001:798195 *
DATABASE CAPLUS [online] 1962, SARETT ET AL: "Benzimidazoles carrying thiazolyl, thiadiazolyl, and isothiazolyl substituents in the 2-position", XP002978634, accession no. STN Database accession no. 1962:79451 *
DATABASE CAPLUS [online] 1964, MERCK & CO., INC.: "Substituted benzimidazoles", XP002978635, accession no. STN Database accession no. 1965:15351 *
DATABASE CAPLUS [online] 1972, OGURA ET AL: "Heterocyclic compounds. 10. Synthesis of some imidazo[1,2-a]benzimidazoles with potent analgetic activities", XP002978633, accession no. STN Database accession no. 1972:560002 *
DATABASE CAPLUS [online] 1973, EDWARDS P.N.: "Imidazole derivatives", XP002978630, accession no. STN Database accession no. 1973:418714 *
DATABASE CAPLUS [online] 1975, E.R. SQUIBB AND SONS, INC.: "Pridyl-1H-benzimidazole N-oxide", XP002978636, accession no. STN Database accession no. 1975:156304 *
DATABASE CAPLUS [online] 1976, AGAI ET AL: "Condensed 1,3,5-triazepines. III. Derivatives of 4,5-dihydro-[1,3,5]triazepino[1,2-a]benzimidazole", XP002978632, accession no. STN Database accession no. 1976:478096 *
DATABASE CAPLUS [online] 1983, FRETER ET AL: "Substituted N-(4-indolylpiperidinoalkyl)benzimidazolones and their use as pharmaceutical preparations", XP002978628, accession no. STN Database accession no. 1983:160710 *
DATABASE CAPLUS [online] 2000, TEUBER ET AL: "Preparation of aminobenzimidazoles and guanidines as novel potassium channel blocking agents", XP002978631, accession no. STN Database accession no. 2000:34861 *
DATABASE CAPLUS [online] October 2002 (2002-10-01), FONQUERNA ET AL: "Preparation of indolylpiperidines as antihistaminic and antiallergic agents", XP002978629, accession no. STN Database accession no. 2002:353452 *
DATABASE CAPLUS [online] WARNER-LAMBERT CO: "Preparation and testing of antiarteriosclerotic substituted benzimidazol-2-yl- and 3H-imidazo[4,5-b]pyridin-2-ylphenoxyalkanoic acids and their salts and esters", XP002978637, accession no. STN Database accession no. 1988:131822 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 15, no. 9, 1972, pages 923 - 926 *
TETRAHEDRON, vol. 32, no. 7, 1976, pages 839 - 842 *

Also Published As

Publication number Publication date
AU2003297597A1 (en) 2004-06-18
WO2004047769A2 (en) 2004-06-10
AU2003297597A8 (en) 2004-06-18

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