WO2004020662A3 - Method and nucleic acids for the analysis of breast cell proliferative disorders - Google Patents

Method and nucleic acids for the analysis of breast cell proliferative disorders Download PDF

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Publication number
WO2004020662A3
WO2004020662A3 PCT/EP2003/007827 EP0307827W WO2004020662A3 WO 2004020662 A3 WO2004020662 A3 WO 2004020662A3 EP 0307827 W EP0307827 W EP 0307827W WO 2004020662 A3 WO2004020662 A3 WO 2004020662A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferative
proliferative disorders
breast cell
analysis
nucleic acids
Prior art date
Application number
PCT/EP2003/007827
Other languages
French (fr)
Other versions
WO2004020662A2 (en
Inventor
Sabine Maier
Original Assignee
Epigenomics Ag
Sabine Maier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10255104A external-priority patent/DE10255104A1/en
Application filed by Epigenomics Ag, Sabine Maier filed Critical Epigenomics Ag
Priority to US10/526,108 priority Critical patent/US20060292564A1/en
Priority to AU2003250989A priority patent/AU2003250989A1/en
Priority to EP03790802A priority patent/EP1540014A2/en
Publication of WO2004020662A2 publication Critical patent/WO2004020662A2/en
Publication of WO2004020662A3 publication Critical patent/WO2004020662A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of breast cell proliferative disorders, or the predisposition to breast cell proliferative disorders.
PCT/EP2003/007827 2002-08-27 2003-07-18 Method and nucleic acids for the analysis of breast cell proliferative disorders WO2004020662A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/526,108 US20060292564A1 (en) 2002-08-27 2003-07-18 Method and nucleic acids for the analysis of breast cell proliferative disorders
AU2003250989A AU2003250989A1 (en) 2002-08-27 2003-07-18 Method and nucleic acids for the analysis of breast cell proliferative disorders
EP03790802A EP1540014A2 (en) 2002-08-27 2003-07-18 Method and nucleic acids for the analysis of breast cell proliferative disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10239313 2002-08-27
DE10239313.3 2002-08-27
DE10255104A DE10255104A1 (en) 2002-08-27 2002-11-26 Methods and nucleic acids for the analysis of proliferative diseases of breast cells
DE10255104.9 2002-11-26

Publications (2)

Publication Number Publication Date
WO2004020662A2 WO2004020662A2 (en) 2004-03-11
WO2004020662A3 true WO2004020662A3 (en) 2004-08-26

Family

ID=31979456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/007827 WO2004020662A2 (en) 2002-08-27 2003-07-18 Method and nucleic acids for the analysis of breast cell proliferative disorders

Country Status (4)

Country Link
US (1) US20060292564A1 (en)
EP (1) EP1540014A2 (en)
AU (1) AU2003250989A1 (en)
WO (1) WO2004020662A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
EP1778865A1 (en) 2004-06-23 2007-05-02 Epigenomics AG Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
EP2302073A1 (en) * 2004-07-18 2011-03-30 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
WO2007019670A1 (en) * 2005-07-01 2007-02-22 Graham, Robert Method and nucleic acids for the improved treatment of breast cancers
WO2007033834A2 (en) * 2005-09-23 2007-03-29 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the analysis of nucleic acid methylation
US20090317810A1 (en) * 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
WO2007121988A1 (en) * 2006-04-24 2007-11-01 Epiontis Gmbh Personalizing cancer chemotherapy based on methylation and germ-line mutational analysis of brca-1
US20100297067A1 (en) * 2007-05-14 2010-11-25 The Johns Hopkins University Methylation markers for prostate cancer and methods of use
EP2193210B1 (en) * 2007-09-17 2014-11-12 Koninklijke Philips N.V. Method for the analysis of ovarian cancer disorders
JP5604300B2 (en) 2007-09-17 2014-10-08 コーニンクレッカ フィリップス エヌ ヴェ Breast cancer disease analysis method
US8609333B2 (en) * 2007-10-01 2013-12-17 University Of Southern California Detection of methylated DNA and DNA mutations
CN102099485A (en) * 2007-10-23 2011-06-15 临床基因组学有限公司 A method of diagnosing neoplasms - II
US20100204062A1 (en) * 2008-11-07 2010-08-12 University Of Southern California Calibration methods for multiplexed sensor arrays
US20120053071A1 (en) 2008-12-18 2012-03-01 Koninklijke Philips Electronics N.V. Method for the detection of dna methylation patterns
WO2010115143A1 (en) * 2009-04-03 2010-10-07 University Of Southern California Surface modification of nanosensor platforms to increase sensitivity and reproducibility
JP5757572B2 (en) * 2009-07-03 2015-07-29 国立大学法人 東京大学 Method for determining the presence or absence of cancer cells and method for determining the prognosis of cancer patients
WO2011128820A2 (en) 2010-04-16 2011-10-20 Koninklijke Philips Electronics N.V. Methods for the analysis of breast cancer disorders

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US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO2001029262A2 (en) * 1999-10-15 2001-04-26 Orchid Biosciences, Inc. Genotyping reagents, kits and methods of use thereof
WO2001040521A2 (en) * 1999-11-30 2001-06-07 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001077373A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Detection of variations in the dna methylation profile
WO2002038801A1 (en) * 2000-11-13 2002-05-16 Human Genetic Signatures Pty Ltd Detection of methylated dna molecules
WO2002059347A2 (en) * 2001-01-26 2002-08-01 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

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US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
WO2001059064A2 (en) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
CN1355305A (en) * 2000-11-24 2002-06-26 复旦大学 Polypeptide-Ser/Thr protein kinase 9.79 and polynucleotide for coding it

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO2001029262A2 (en) * 1999-10-15 2001-04-26 Orchid Biosciences, Inc. Genotyping reagents, kits and methods of use thereof
WO2001040521A2 (en) * 1999-11-30 2001-06-07 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001077373A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Detection of variations in the dna methylation profile
WO2002038801A1 (en) * 2000-11-13 2002-05-16 Human Genetic Signatures Pty Ltd Detection of methylated dna molecules
WO2002059347A2 (en) * 2001-01-26 2002-08-01 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DE IORIO P ET AL: "Implication of laminin and collagen type IV expression in the progression of breast carcinoma.", ANTICANCER RESEARCH. GREECE 2001 MAR-APR, vol. 21, no. 2B, March 2001 (2001-03-01), pages 1395 - 1399, XP008027518, ISSN: 0250-7005 *
GITAN RAAD S ET AL: "Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 12, no. 1, January 2002 (2002-01-01), pages 158 - 164, XP002208051, ISSN: 1088-9051 *
HUANG TIM HUI-MING ET AL: "Methylation profiling of CpG islands in human breast cancer cells", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 3, March 1999 (1999-03-01), pages 459 - 470, XP002175857, ISSN: 0964-6906 *
See also references of EP1540014A2 *
YAN P S ET AL: "Dissecting complex epigenetic alterations in breast cancer using CpG Island microarrays", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, no. 23, 1 December 2001 (2001-12-01), pages 8375 - 8380, XP002243660, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
AU2003250989A1 (en) 2004-03-19
US20060292564A1 (en) 2006-12-28
WO2004020662A2 (en) 2004-03-11
EP1540014A2 (en) 2005-06-15

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