WO2004012719A1 - Improved transdermal delivery system - Google Patents
Improved transdermal delivery system Download PDFInfo
- Publication number
- WO2004012719A1 WO2004012719A1 PCT/EP2003/008319 EP0308319W WO2004012719A1 WO 2004012719 A1 WO2004012719 A1 WO 2004012719A1 EP 0308319 W EP0308319 W EP 0308319W WO 2004012719 A1 WO2004012719 A1 WO 2004012719A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- tds
- matrix
- amine functional
- functional drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA05000349A MXPA05000349A (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system. |
SI200330559T SI1524971T1 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
NZ537476A NZ537476A (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
BR0313092-4A BR0313092A (en) | 2002-07-30 | 2003-07-28 | Enhanced Transdermal Release System |
CA2490573A CA2490573C (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
JP2004525348A JP4837915B2 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
AU2003266252A AU2003266252B2 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
EP03766330A EP1524971B1 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
DK03766330T DK1524971T3 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
DE60309329T DE60309329T2 (en) | 2002-07-30 | 2003-07-28 | IMPROVED TRANSDERMAL DELIVERY SYSTEM |
IL165917A IL165917A (en) | 2002-07-30 | 2004-12-22 | Transdermal delivery system |
ZA2005/00255A ZA200500255B (en) | 2002-07-30 | 2005-01-11 | Improved transdermal delivery system |
NO20050770A NO334187B1 (en) | 2002-07-30 | 2005-02-11 | Improved transdermal delivery system |
HK06103512.7A HK1083458A1 (en) | 2002-07-30 | 2006-03-20 | Improved transdermal delivery system |
CY20061101845T CY1105878T1 (en) | 2002-07-30 | 2006-12-21 | IMPROVED INTER DEPARTMENT GRANTING SYSTEM |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02016864.7 | 2002-07-30 | ||
EP02016864A EP1386604A1 (en) | 2002-07-30 | 2002-07-30 | Improved transdermal delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004012719A1 true WO2004012719A1 (en) | 2004-02-12 |
Family
ID=30011092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008319 WO2004012719A1 (en) | 2002-07-30 | 2003-07-28 | Improved transdermal delivery system |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP1386604A1 (en) |
JP (1) | JP4837915B2 (en) |
KR (1) | KR101016914B1 (en) |
CN (1) | CN100558350C (en) |
AT (1) | ATE343380T1 (en) |
AU (1) | AU2003266252B2 (en) |
BR (1) | BR0313092A (en) |
CA (1) | CA2490573C (en) |
CY (1) | CY1105878T1 (en) |
DE (1) | DE60309329T2 (en) |
DK (1) | DK1524971T3 (en) |
ES (1) | ES2273042T3 (en) |
HK (1) | HK1083458A1 (en) |
IL (1) | IL165917A (en) |
MX (1) | MXPA05000349A (en) |
NO (1) | NO334187B1 (en) |
NZ (1) | NZ537476A (en) |
PL (1) | PL376999A1 (en) |
PT (1) | PT1524971E (en) |
SI (1) | SI1524971T1 (en) |
WO (1) | WO2004012719A1 (en) |
ZA (1) | ZA200500255B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7872041B2 (en) | 2004-03-24 | 2011-01-18 | Ucb Pharma Gmbh | Use of rotigotine for treating and preventing Parkinson's plus syndrome |
US8283376B2 (en) | 2003-12-24 | 2012-10-09 | Ucb Pharma Gmbh | Use of substituted 2-aminotetralins for preventive treatment of parkinson's disease |
DE102011090178A1 (en) | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with low tendency to spontaneous crystallization |
EP3854388A1 (en) | 2020-01-24 | 2021-07-28 | Luye Pharma Switzerland AG | Transdermal therapeutic system comprising rotigotine and at least one non-amine-resistant silicone adhesive |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
US9155725B2 (en) | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
JP6054013B2 (en) * | 2008-02-27 | 2016-12-27 | 久光製薬株式会社 | Patch preparation |
ME03053B (en) * | 2009-12-22 | 2018-10-20 | Ucb Biopharma Sprl | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
TW201431570A (en) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | Multi-day patch for the transdermal administration of rotigotine |
BR112015032929B1 (en) | 2013-07-03 | 2022-08-23 | Lts Lohmann Therapie-Systeme Ag | TRANSDERMAL THERAPEUTIC SYSTEM WITH ELECTRONIC COMPONENT AND PRODUCTION METHODS OF A TRANSDERMAL THERAPEUTIC SYSTEM |
US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
CN106456567A (en) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗系统股份公司 | Method for adjusting the release of active agent in a transdermal delivery system |
CN106456566B (en) | 2014-05-20 | 2020-06-16 | Lts勒曼治疗系统股份公司 | Transdermal delivery system containing rotigotine |
EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994007468A1 (en) * | 1992-10-05 | 1994-04-14 | Cygnus Therapeutic Systems | Two-phase matrix for sustained release drug delivery device |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
WO1998000126A1 (en) * | 1996-06-28 | 1998-01-08 | Sepracor, Inc. | Treating urinary incontinence using (s)-oxybutynin and (s)-desethyloxybutynin |
WO1999049852A1 (en) * | 1998-03-30 | 1999-10-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof |
DE19814083A1 (en) * | 1998-03-30 | 1999-10-14 | Lohmann Therapie Syst Lts | Process for the production of transdermal therapeutic systems using basic alkali metal salts for converting active substance salts into the free bases |
FR2792529A1 (en) * | 1999-04-26 | 2000-10-27 | Sod Conseils Rech Applic | Patches containing 1,2,3,4-tetrahydro-8-(5-isoxazolyl)-N,N-diisopropyl-2-naphthalenamine for transdermal treatment of irritable bowel syndrome |
WO2002026217A2 (en) * | 2000-09-29 | 2002-04-04 | 3M Innovative Properties Company | Composition for the transdermal delivery of fentanyl |
DE10060550C1 (en) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermal therapeutic system for administration of oxybutynin, especially for treatment of bladder dysfunction, having two-phase matrix layer of active agent-containing droplets dispersed in adhesive |
WO2002074286A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Transdermal patch for administering fentanyl |
EP1256340A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1311696B1 (en) * | 1999-06-22 | 2002-03-19 | Zanussi Elettromecc | REFRIGERANT FLUID COMPRESSOR OPERATED BY AN ELECTRIC MOTOR WITH VARIABLE POWER FREQUENCY |
JP2002045699A (en) * | 2000-08-08 | 2002-02-12 | Mitsubishi Electric Corp | Layer-structured electrochemical catalyst for exhaust gas cleaning |
EP1372614A4 (en) * | 2001-03-16 | 2007-10-31 | Andrx Pharmaceuticals Llc | Controlled release sulfonylurea formulation |
EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
-
2002
- 2002-07-30 EP EP02016864A patent/EP1386604A1/en not_active Withdrawn
-
2003
- 2003-07-28 KR KR1020057001101A patent/KR101016914B1/en active IP Right Grant
- 2003-07-28 BR BR0313092-4A patent/BR0313092A/en not_active Application Discontinuation
- 2003-07-28 AT AT03766330T patent/ATE343380T1/en active
- 2003-07-28 CA CA2490573A patent/CA2490573C/en not_active Expired - Lifetime
- 2003-07-28 PL PL376999A patent/PL376999A1/en not_active Application Discontinuation
- 2003-07-28 SI SI200330559T patent/SI1524971T1/en unknown
- 2003-07-28 AU AU2003266252A patent/AU2003266252B2/en not_active Expired
- 2003-07-28 WO PCT/EP2003/008319 patent/WO2004012719A1/en active IP Right Grant
- 2003-07-28 NZ NZ537476A patent/NZ537476A/en not_active IP Right Cessation
- 2003-07-28 PT PT03766330T patent/PT1524971E/en unknown
- 2003-07-28 DK DK03766330T patent/DK1524971T3/en active
- 2003-07-28 CN CNB038184397A patent/CN100558350C/en not_active Expired - Lifetime
- 2003-07-28 MX MXPA05000349A patent/MXPA05000349A/en active IP Right Grant
- 2003-07-28 ES ES03766330T patent/ES2273042T3/en not_active Expired - Lifetime
- 2003-07-28 JP JP2004525348A patent/JP4837915B2/en not_active Expired - Lifetime
- 2003-07-28 EP EP03766330A patent/EP1524971B1/en not_active Expired - Lifetime
- 2003-07-28 DE DE60309329T patent/DE60309329T2/en not_active Expired - Lifetime
-
2004
- 2004-12-22 IL IL165917A patent/IL165917A/en active IP Right Grant
-
2005
- 2005-01-11 ZA ZA2005/00255A patent/ZA200500255B/en unknown
- 2005-02-11 NO NO20050770A patent/NO334187B1/en not_active IP Right Cessation
-
2006
- 2006-03-20 HK HK06103512.7A patent/HK1083458A1/en not_active IP Right Cessation
- 2006-12-21 CY CY20061101845T patent/CY1105878T1/en unknown
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994007468A1 (en) * | 1992-10-05 | 1994-04-14 | Cygnus Therapeutic Systems | Two-phase matrix for sustained release drug delivery device |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US5834010A (en) * | 1995-04-26 | 1998-11-10 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
WO1998000126A1 (en) * | 1996-06-28 | 1998-01-08 | Sepracor, Inc. | Treating urinary incontinence using (s)-oxybutynin and (s)-desethyloxybutynin |
WO1999049852A1 (en) * | 1998-03-30 | 1999-10-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof |
DE19814083A1 (en) * | 1998-03-30 | 1999-10-14 | Lohmann Therapie Syst Lts | Process for the production of transdermal therapeutic systems using basic alkali metal salts for converting active substance salts into the free bases |
FR2792529A1 (en) * | 1999-04-26 | 2000-10-27 | Sod Conseils Rech Applic | Patches containing 1,2,3,4-tetrahydro-8-(5-isoxazolyl)-N,N-diisopropyl-2-naphthalenamine for transdermal treatment of irritable bowel syndrome |
WO2002026217A2 (en) * | 2000-09-29 | 2002-04-04 | 3M Innovative Properties Company | Composition for the transdermal delivery of fentanyl |
DE10060550C1 (en) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermal therapeutic system for administration of oxybutynin, especially for treatment of bladder dysfunction, having two-phase matrix layer of active agent-containing droplets dispersed in adhesive |
WO2002074286A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Transdermal patch for administering fentanyl |
EP1256340A1 (en) * | 2001-05-08 | 2002-11-13 | Schwarz Pharma Ag | Improved transdermal therapeutic system for the treatment of Parkinson's disease |
Non-Patent Citations (2)
Title |
---|
ROY S D ET AL: "CONTROLLED TRANSDERMAL DELIVERY OF FENTANYL: CHARACTERIZATIONS OF PRESSURE-SENSITIVE ADHESIVES FOR MATRIX PATCH DESIGN", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 85, no. 5, 1 May 1996 (1996-05-01), pages 491 - 495, XP000583527, ISSN: 0022-3549 * |
ROY S D ET AL: "TRANSDERMAL DELIVERY OF NARCOTIC ANALGESICS: PH, ANATOMICAL, AND SUBJECT INFLUENCES ON CUTANEOUS PERMEABILITY OF FENTANYL AND SUFENTANIL", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 7, no. 8, 1990, pages 842 - 847, XP002923066, ISSN: 0724-8741 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8283376B2 (en) | 2003-12-24 | 2012-10-09 | Ucb Pharma Gmbh | Use of substituted 2-aminotetralins for preventive treatment of parkinson's disease |
US7872041B2 (en) | 2004-03-24 | 2011-01-18 | Ucb Pharma Gmbh | Use of rotigotine for treating and preventing Parkinson's plus syndrome |
DE102011090178A1 (en) | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with low tendency to spontaneous crystallization |
WO2013098390A1 (en) | 2011-12-30 | 2013-07-04 | Ucb Pharma Gmbh | Transdermal therapeutic system with a low tendency to spontaneously crystallize |
EP3854388A1 (en) | 2020-01-24 | 2021-07-28 | Luye Pharma Switzerland AG | Transdermal therapeutic system comprising rotigotine and at least one non-amine-resistant silicone adhesive |
WO2021148634A1 (en) | 2020-01-24 | 2021-07-29 | Luye Pharma Switzerland Ag | Transdermal therapeutic system comprising the ingredient rotigotine and at least one non-amine-resistant silicone adhesive |
Also Published As
Publication number | Publication date |
---|---|
KR20050025638A (en) | 2005-03-14 |
EP1524971B1 (en) | 2006-10-25 |
CY1105878T1 (en) | 2011-02-02 |
ATE343380T1 (en) | 2006-11-15 |
ES2273042T3 (en) | 2007-05-01 |
PT1524971E (en) | 2007-01-31 |
NO20050770L (en) | 2005-02-11 |
CA2490573C (en) | 2011-06-07 |
SI1524971T1 (en) | 2007-02-28 |
PL376999A1 (en) | 2006-01-23 |
DK1524971T3 (en) | 2007-02-19 |
CA2490573A1 (en) | 2004-02-12 |
BR0313092A (en) | 2005-06-21 |
CN1671365A (en) | 2005-09-21 |
NZ537476A (en) | 2007-08-31 |
NO334187B1 (en) | 2014-01-13 |
MXPA05000349A (en) | 2005-03-31 |
EP1524971A1 (en) | 2005-04-27 |
IL165917A0 (en) | 2006-01-15 |
AU2003266252B2 (en) | 2008-11-20 |
ZA200500255B (en) | 2006-01-25 |
KR101016914B1 (en) | 2011-02-22 |
JP2005535686A (en) | 2005-11-24 |
HK1083458A1 (en) | 2006-07-07 |
CN100558350C (en) | 2009-11-11 |
IL165917A (en) | 2007-07-24 |
JP4837915B2 (en) | 2011-12-14 |
DE60309329D1 (en) | 2006-12-07 |
DE60309329T2 (en) | 2008-04-17 |
AU2003266252A1 (en) | 2004-02-23 |
EP1386604A1 (en) | 2004-02-04 |
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