WO2004010923A3 - Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation - Google Patents

Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation Download PDF

Info

Publication number
WO2004010923A3
WO2004010923A3 PCT/IL2003/000631 IL0300631W WO2004010923A3 WO 2004010923 A3 WO2004010923 A3 WO 2004010923A3 IL 0300631 W IL0300631 W IL 0300631W WO 2004010923 A3 WO2004010923 A3 WO 2004010923A3
Authority
WO
WIPO (PCT)
Prior art keywords
bbb
subject
chemical agent
brain
cerebral circulation
Prior art date
Application number
PCT/IL2003/000631
Other languages
French (fr)
Other versions
WO2004010923A2 (en
Inventor
Yossi Gross
Alon Shalev
Benny Shalita
Original Assignee
Brainsgate Ltd
Yossi Gross
Alon Shalev
Benny Shalita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US40016702P priority Critical
Priority to US60/400,167 priority
Application filed by Brainsgate Ltd, Yossi Gross, Alon Shalev, Benny Shalita filed Critical Brainsgate Ltd
Publication of WO2004010923A2 publication Critical patent/WO2004010923A2/en
Publication of WO2004010923A3 publication Critical patent/WO2004010923A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0618Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0693Brain, cerebrum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0546Nasal electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0548Oral electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • A61N1/306Arrangements where at least part of the apparatus is introduced into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36189Control systems using modulation techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators

Abstract

A chemical agent delivery system is provided, including a chemical agent supplied to a body of a subject for delivery to a site in a central nervous system of said subject via blood of said subject; and a stimulator (4) for stimulating parasympathetic fibers associated with the sphenopalatine ganglion (6), thereby to render a blood brain barrier (BBB) of said subject permeable to said chemical agent during at least a portion of the time that said chemical agent is present in said blood.
PCT/IL2003/000631 2002-07-31 2003-07-31 Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation WO2004010923A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US40016702P true 2002-07-31 2002-07-31
US60/400,167 2002-07-31

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003247140A AU2003247140A1 (en) 2002-07-31 2003-07-31 Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation
EP20030771242 EP1538973A2 (en) 2002-07-31 2003-07-31 Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation

Publications (2)

Publication Number Publication Date
WO2004010923A2 WO2004010923A2 (en) 2004-02-05
WO2004010923A3 true WO2004010923A3 (en) 2004-08-19

Family

ID=31188663

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000631 WO2004010923A2 (en) 2002-07-31 2003-07-31 Delivering compounds to the brain by modifying properties of the bbb and cerebral circulation

Country Status (3)

Country Link
EP (1) EP1538973A2 (en)
AU (1) AU2003247140A1 (en)
WO (1) WO2004010923A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US7684859B2 (en) 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10039736B1 (en) 2015-10-19 2018-08-07 Tian Xia Method for transnasal delivery of blood-brain barrier permeation agent and therapeutic agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040015068A1 (en) * 2000-05-08 2004-01-22 Alon Shalev Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040015068A1 (en) * 2000-05-08 2004-01-22 Alon Shalev Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US9161912B2 (en) 2008-12-23 2015-10-20 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds

Also Published As

Publication number Publication date
WO2004010923A2 (en) 2004-02-05
EP1538973A2 (en) 2005-06-15
AU2003247140A1 (en) 2004-02-16
AU2003247140A8 (en) 2004-02-16

Similar Documents

Publication Publication Date Title
Breckenridge et al. Theophylline, epinephrine, and neostigmine facilitation of neuromuscular transmission.
Dahlöf et al. Neuropeptide Y (NPY): enhancement of blood pressure increase upon α-adrenoceptor activation and direct pressor effects in pithed rats
Sugar et al. Anoxia and brain potentials
Nathan et al. Treatment of post-herpetic neuralgia by prolonged electric stimulation
Long et al. Inhibition of the sympathetic nervous system by 5, 6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine.
Blier et al. Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain.
Armitage et al. Effects of nicotine and some nicotine‐like compounds injected into the cerebral ventricles of the cat
Ashton et al. Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction.
US7962219B2 (en) Methods and systems for stimulating a motor cortex of the brain to treat a medical condition
Petty et al. Cardiovascular effects of β-endorphin after microinjection into the nucleus tractus solitarii of the anaesthetised rat
Balon et al. Sexual dysfunction during antidepressant treatment.
Babar et al. Vasopressin versus epinephrine during cardiopulmonary resuscitation: a randomized swine outcome study
TWI253349B (en) Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
Mabry et al. Serotonergic inhibition of catecholamine-induced behavioral arousal
Milby et al. Vagus nerve stimulation for epilepsy and depression
WO2002024214A3 (en) Use of glp -2 in combination with another therapeutic agent in bone-related and nutrition-related disorders
WO2004105702A3 (en) Foamable pharmaceutical compositions and methods for treating a disorder
AT97809T (en) Use of 5-methyltetrahydrofolsaeure, 5formyltetrahydrofolsaeure as well as their pharmaceutically acceptable salts for the production of medicaments having controlled release and effective organic mental disorders in therapy as well as the corresponding drug.
MY129512A (en) Novel medicament compositions, based on tiotropium bromide and salmeterol
BR0108977A (en) azacyclic compounds for use in treating diseases with serotonin relaciondas
NZ518736A (en) N6 heterocyclic 8-modified adenosine derivatives
WO2009055740A3 (en) Method of preventing adverse effects by glp-1
BR9911161A (en) Process for the treatment of a particular volume of plant or animal tissue, to produce at least one photoactivated agent in a particular volume of material for the medical treatment of a particular volume of tissue and apparatus for treating a volume particular plant or animal tissue, for administering a photodynamic medical treatment.
SG157961A1 (en) Modulators of pharmacological agents
NO20062319A (en) Controlled frigivelsessterile injectable aripiprazolpreparater and progress feed

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003771242

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2004524047

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 158/MUMNP/2005

Country of ref document: IN

WWP Wipo information: published in national office

Ref document number: 2003771242

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2003771242

Country of ref document: EP