WO2004009618A2 - Recombinant production of mixtures of antibodies - Google Patents
Recombinant production of mixtures of antibodies Download PDFInfo
- Publication number
- WO2004009618A2 WO2004009618A2 PCT/EP2003/007690 EP0307690W WO2004009618A2 WO 2004009618 A2 WO2004009618 A2 WO 2004009618A2 EP 0307690 W EP0307690 W EP 0307690W WO 2004009618 A2 WO2004009618 A2 WO 2004009618A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- mixture
- nucleic acid
- light chain
- host cell
- Prior art date
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Abstract
Description
Claims
Priority Applications (24)
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AT03764997T ATE514717T1 (en) | 2002-07-18 | 2003-07-15 | RECOMBINANT PRODUCTION OF ANTIBODIES MIXTURES |
CA2492377A CA2492377C (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
EP10186063.3A EP2314629B2 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
AU2003250074A AU2003250074B2 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
EP03764997A EP1523496B1 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
DK03764997.7T DK1523496T3 (en) | 2002-07-18 | 2003-07-15 | Recombinant preparation of mixture of antibodies |
NZ537277A NZ537277A (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
SI200332045T SI1523496T1 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
CNB038170779A CN100480260C (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
ES03764997T ES2368733T3 (en) | 2002-07-18 | 2003-07-15 | RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES. |
JP2004522465A JP4836451B2 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of antibody mixtures |
US10/644,256 US8236561B2 (en) | 1999-04-15 | 2003-08-20 | Efficient production of IgA in recombinant mammalian cells |
US11/039,767 US7262028B2 (en) | 2002-07-18 | 2005-01-18 | Recombinant production of mixtures of antibodies |
HK05103474.4A HK1070902A1 (en) | 2002-07-18 | 2005-04-22 | Recombinant production of mixtures of antibodies |
US11/593,280 US7932360B2 (en) | 2002-07-18 | 2006-11-06 | Recombinant production of mixtures of antibodies |
US11/593,279 US7429486B2 (en) | 2002-07-18 | 2006-11-06 | Recombinant production of mixtures of antibodies |
US12/221,021 US7927834B2 (en) | 2002-07-18 | 2008-07-29 | Recombinant production of mixtures of antibodies |
AU2010249150A AU2010249150B9 (en) | 2002-07-18 | 2010-12-02 | Recombinant production of mixtures of antibodies |
US12/932,719 US9303081B2 (en) | 2002-07-18 | 2011-03-04 | Recombinant production of mixtures of antibodies |
US13/795,637 US20130243773A1 (en) | 2002-07-18 | 2013-03-12 | Recombinant production of mixtures of antibodies |
US15/090,505 US10934571B2 (en) | 2002-07-18 | 2016-04-04 | Recombinant production of mixtures of antibodies |
US15/158,543 USRE47770E1 (en) | 2002-07-18 | 2016-05-18 | Recombinant production of mixtures of antibodies |
US15/842,303 US20180094289A1 (en) | 2002-07-18 | 2017-12-14 | Recombinant production of mixtures of antibodies |
US15/855,258 US20180112247A1 (en) | 2002-07-18 | 2017-12-27 | Recombinant production of mixtures of antibodies |
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US39706602P | 2002-07-18 | 2002-07-18 | |
EP02077953.4 | 2002-07-18 | ||
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US60/397,066 | 2002-07-18 | ||
EPPCT/EP03/50201 | 2003-05-27 | ||
EPPCT/EP03/50201 | 2003-05-27 |
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EPPCT/EP03/50201 Continuation | 1999-04-15 | 2003-05-27 |
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US09/549,463 Continuation-In-Part US6855544B1 (en) | 1999-04-15 | 2000-04-14 | Recombinant protein production in a human cell |
EP10186063.3A Previously-Filed-Application EP2314629B2 (en) | 2002-07-18 | 2003-07-15 | Recombinant production of mixtures of antibodies |
US11/039,767 Continuation US7262028B2 (en) | 2002-07-18 | 2005-01-18 | Recombinant production of mixtures of antibodies |
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WO2004009618A2 true WO2004009618A2 (en) | 2004-01-29 |
WO2004009618A3 WO2004009618A3 (en) | 2004-11-04 |
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PCT/EP2003/007690 WO2004009618A2 (en) | 1999-04-15 | 2003-07-15 | Recombinant production of mixtures of antibodies |
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US (9) | US7262028B2 (en) |
EP (2) | EP2314629B2 (en) |
JP (4) | JP4836451B2 (en) |
CN (3) | CN101537180B (en) |
AT (1) | ATE514717T1 (en) |
AU (2) | AU2003250074B2 (en) |
CA (3) | CA2965865C (en) |
CY (1) | CY1111886T1 (en) |
DK (2) | DK1523496T3 (en) |
ES (2) | ES2442615T5 (en) |
HK (1) | HK1070902A1 (en) |
NZ (1) | NZ537277A (en) |
PT (2) | PT2314629E (en) |
SI (1) | SI1523496T1 (en) |
WO (1) | WO2004009618A2 (en) |
Cited By (141)
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WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
EP1508576A1 (en) * | 2003-08-20 | 2005-02-23 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
WO2005118644A3 (en) * | 2004-05-27 | 2006-03-09 | Crucell Holland Bv | Binding molecules capable of neutralizing rabies virus and uses thereof |
US20060159673A1 (en) * | 2003-01-21 | 2006-07-20 | Tetsuo Kojima | Methods of screening light chain of antibody |
US20070111312A1 (en) * | 2005-11-16 | 2007-05-17 | Cevec Pharmaceuticals Gmbh | Method for the production of permanent human cell lines |
WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
WO2007048077A3 (en) * | 2005-10-21 | 2007-07-05 | Gtc Biotherapeutics Inc | Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
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EP1975184A2 (en) | 2007-03-26 | 2008-10-01 | Albrecht Moritz | Serine or threonine phosphorylation sites |
EP1983003A2 (en) | 2007-04-19 | 2008-10-22 | Peter Hornbeck | Tyrosine phosphorylation sites and antibodies specific for them |
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EP2123679A2 (en) | 2007-05-01 | 2009-11-25 | Peter Hornbeck | Tyrosine phosphorylation sites |
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US7807789B2 (en) | 2004-12-21 | 2010-10-05 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in EGFR-signaling pathways |
US7888480B2 (en) | 2005-08-31 | 2011-02-15 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in leukemia signaling pathways |
US7887805B2 (en) | 2007-03-01 | 2011-02-15 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
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