WO2004007704A3 - Neuronally expressed tryptophane hydroxylase and its use - Google Patents

Neuronally expressed tryptophane hydroxylase and its use Download PDF

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Publication number
WO2004007704A3
WO2004007704A3 PCT/EP2003/007744 EP0307744W WO2004007704A3 WO 2004007704 A3 WO2004007704 A3 WO 2004007704A3 EP 0307744 W EP0307744 W EP 0307744W WO 2004007704 A3 WO2004007704 A3 WO 2004007704A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid sequences
relates
neuronal
proteins
Prior art date
Application number
PCT/EP2003/007744
Other languages
French (fr)
Other versions
WO2004007704A2 (en
Inventor
Diego Walther
Michael Bader
Original Assignee
Max Delbrueck Ct Fue Molekular
Diego Walther
Michael Bader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Ct Fue Molekular, Diego Walther, Michael Bader filed Critical Max Delbrueck Ct Fue Molekular
Priority to EP03763879A priority Critical patent/EP1521823B1/en
Priority to US10/519,826 priority patent/US20060275759A1/en
Priority to AU2003250975A priority patent/AU2003250975A1/en
Publication of WO2004007704A2 publication Critical patent/WO2004007704A2/en
Publication of WO2004007704A3 publication Critical patent/WO2004007704A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to novel, specifically neuronal expressed proteins with tryptophane hydroxylase activity, nucleic acid sequences, recombinant nucleic acid molecules containing these nucleic acid sequences or vectors containing these nucleic acid sequences or the recombinant nucleic acid molecules encoding for a neuronal tryptophane hydroxylase. The invention also relates to transgenic organisms containing these nucleic acid sequences, the recombinant nucleic acid molecules or the above cited vectors. The invention moreover refers to mono- or polyclonal antibodies directed against the isolated proteins. Furthermore, the invention relates to the use of these nucleic acid sequences and proteins for diagnosis, predisposition, therapy and monitoring of neuronal diseases. Possible fields of application among others are medicine and the pharmaceutical industry.
PCT/EP2003/007744 2002-07-16 2003-07-16 Neuronally expressed tryptophane hydroxylase and its use WO2004007704A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03763879A EP1521823B1 (en) 2002-07-16 2003-07-16 Neuronally expressed tryptophane hydroxylase and its use
US10/519,826 US20060275759A1 (en) 2002-07-16 2003-07-16 Neuronally expressed tryptophane hydroxylase and its use
AU2003250975A AU2003250975A1 (en) 2002-07-16 2003-07-16 Neuronally expressed tryptophane hydroxylase and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10232151.5 2002-07-16
DE10232151A DE10232151A1 (en) 2002-07-16 2002-07-16 Neuronically expressed tryptophan hydroxylase and its use

Publications (2)

Publication Number Publication Date
WO2004007704A2 WO2004007704A2 (en) 2004-01-22
WO2004007704A3 true WO2004007704A3 (en) 2004-04-08

Family

ID=30010038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/007744 WO2004007704A2 (en) 2002-07-16 2003-07-16 Neuronally expressed tryptophane hydroxylase and its use

Country Status (5)

Country Link
US (1) US20060275759A1 (en)
EP (1) EP1521823B1 (en)
AU (1) AU2003250975A1 (en)
DE (1) DE10232151A1 (en)
WO (1) WO2004007704A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005112906A2 (en) 2004-05-21 2005-12-01 Duke University Method for augmenting the effects of serotonin reuptake inhibitors
US8124831B2 (en) 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
KR20150038726A (en) * 2007-06-26 2015-04-08 렉시컨 파마슈티컬스 인코퍼레이티드 Compositions comprising tryptophan hydroxylase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002017891A2 (en) * 2000-08-31 2002-03-07 Max-Delbrück-Centrum für Molekulare Medizin Method for diagnosing neuronal diseases and for treating primary hemostasis deficiency
WO2002097039A2 (en) * 2001-05-29 2002-12-05 Lexicon Genetics Incorporated Novel human hydroxylases and polynucleotides encoding the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002017891A2 (en) * 2000-08-31 2002-03-07 Max-Delbrück-Centrum für Molekulare Medizin Method for diagnosing neuronal diseases and for treating primary hemostasis deficiency
WO2002097039A2 (en) * 2001-05-29 2002-12-05 Lexicon Genetics Incorporated Novel human hydroxylases and polynucleotides encoding the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CASH C D: "Why tryptophan hydroxylase is difficult to purify: A reactive oxygen-derived species-mediated phenomenon that may be implicated in human pathology", GENERAL PHARMACOLOGY, vol. 30, no. 4, April 1998 (1998-04-01), pages 569 - 574, XP002259157, ISSN: 0306-3623 *
CHUNG Y I ET AL: "Immunochemical characterization of brain and pineal tryptophan hydroxylase", JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 16, no. 4, August 2001 (2001-08-01), pages 489 - 497, XP009019879, ISSN: 1011-8934 *
WALTHER D J ET AL: "A unique central tryptophan hydroxylase isoform", BIOCHEMICAL PHARMACOLOGY, vol. 66, no. 9, 1 November 2003 (2003-11-01), pages 1673 - 1680, XP002259158 *
WALTHER D J ET AL: "Synthesis of serotonin by a second tryptophan hydroxylase isoform.", SCIENCE (WASHINGTON D C), vol. 299, no. 5603, 3 January 2003 (2003-01-03), pages 76, XP002259156, ISSN: 0036-8075 (ISSN print) *

Also Published As

Publication number Publication date
US20060275759A1 (en) 2006-12-07
EP1521823B1 (en) 2012-05-23
WO2004007704A2 (en) 2004-01-22
AU2003250975A1 (en) 2004-02-02
DE10232151A1 (en) 2004-02-05
AU2003250975A8 (en) 2004-02-02
EP1521823A2 (en) 2005-04-13

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