WO2004006882A1

WO2004006882A1 - Vesicle-forming cleansing preparation having a high proportion of active substances, method for the production thereof and its use

Info

Publication number: WO2004006882A1
Application number: PCT/EP2003/006504
Authority: WO
Inventors: Rolf D. Beutler; Simone Schatschneider; Valentina Paspaleeva-Kühn
Original assignee: Merz Pharma Gmbh & Co. Kgaa
Priority date: 2002-07-13
Filing date: 2003-06-20
Publication date: 2004-01-22
Also published as: WO2004006882A8; DE10231736A9; AU2003281143A1; DE10231736A1

Abstract

The invention relates to cleansing preparations, particularly bath product compositions, shower products or shampoos, containing surfactants and customary additives, optionally a content of water. These preparations are characterized by having a high proportion of one or more active substances together with one or more non-ethoxylated sterols or a mixture consisting of ethoxylated sterol(s) and ethoxylated sterol(s), whereby the proportion of non-ethoxylated sterols is greater. These surfactant-containing preparations spontaneously form, particularly during use, liposomal structures despite the very high content of active substances such as ethereal oils/extracts, vitamins or the like. The invention also relates to a method for producing surfactant-containing preparations and to the use of these compounds as cleansers and balneotherapeutic products.

Description

Vesicle-forming preparations with high

Proportion of active substance, process for their preparation and their use

description

Subject of the invention

The present invention relates to cleaning preparations, in particular bath compositions, shower baths or shampoos, containing surfactants and conventional additives, possibly containing water, and which are characterized by a high proportion of one or more active ingredients together with one or more (non-ethoxylated) sterols or a mixture of one or more (non-ethoxylated) sterols and one or more ethoxylated sterols, the proportion of non-ethoxylated sterol (s) being higher. These surfactant-containing preparations spontaneously form liposomal structures, especially when used, despite the very high content of active ingredients such as essential oils, vitamins or the like. The invention further relates to a process for the preparation of such surfactant-containing preparations and the use of these preparations as cleaning agents and balneologics.

State of the art

So far, water-based surfactant cleaning products and oil and cream preparations for showering or bathing with a more or less pronounced cleaning effect or regreasing are known.

Vesicular systems have found widespread use in cosmetics and pharmaceuticals as active ingredient carriers and skin care components. Cosmetic gels and emulsions containing liposomes or vesicles are already known. Dispersions containing liposomes or vesicles are already being produced in the pharmaceutical sector. Cleaning products based on liposomes are also available have been described. For example, "Mederma Regulativ- Waschlotion Plus" is a commercially available cleaning product based on emulsions with liposomes. This preparation contains O / W emulsifiers and a fat phase, but no washing-active substances. Liposome formation in bath water from oil bath or oleogel preparations DE-OS 42 05 548 describes bath and shower additives with vesicle-forming properties, which contain fatty oils and / or non-polar substances and also contain one or more oil-soluble surfactants together with one or The oil-soluble surfactants have an HLB value of 6 to 13 and the vesicle-forming lipids have an HLB value between 2 and 6.

DE 196 02 346.7 describes shower oleogels with vesicle-forming properties, which contain more than 30% of one or more lipid components, 0.1 to 20% vesicle-forming substances and customary auxiliaries and additives, and furthermore an emulsifier system composed of one or more W / O and one or more O / W emulsifiers, in a ratio of 1: 2 to 1: 0.2. Lipid-containing cleaning agents of this type, which are intended to compensate for the loss of skin lipids which occurs during the removal of dirt, are produced by incorporating prefabricated vesicle dispersions into the preparation or the liposomes, in particular when used as a bath additive, when used by contact with water from the preparation contained lipids arise. In the case of the products mentioned above, there are either no surfactants or, if they are present, special systems with these are required in conjunction with fatty oils, which are intended to prevent the interactions of the liposomal structures with surface-active substances in aqueous solutions in such a way that they are not dissolved. Furthermore, vesicle-forming lipids, such as phospholipids, sphingolipids or ceramides, have been used to produce liposomal structures in such cleaning products. Sterols are known per se and are available from natural substances. For example, RA Wächter et al. in Perfumery and Cosmetics, Volume 75, No. 11/94, pages 755 to 759, the use of naturally occurring phytosterols as herbal active ingredients in cosmetics. Phytosterols can be obtained from different oils and fats, such as corn oil, rapeseed oil, soybean oil, olive oil etc. and essentially include β-sitosterol, campesterol and stigmasterol. Under the product name Generol ^® 122, a mixed product of the three phytosterol components with a predominant proportion of ß-sitosterol (58.1%), 29.8% campesterol and 4.5% stigmasterol obtained from soybean oil is known. Generol ^® R is obtained from rapeseed oil and essentially comprises 40-60% sitosterol, 30-45% campesterol and 8-18% brassicasterol. In addition, there are also ethoxylated product variants of the phytosterols mentioned, in particular Generol ^® 122 or Generol ^® R. Depending on the degree of ethoxylation, a number of products with different properties are obtained, such as Generol ^® 122 E5 or Generol ^® RE5 (5 mol EO), which is predominantly hydrophobic, as well as such products with a degree of ethoxylation of 10, 16 or 25. The latter products have the properties of a typical O / W emulsifier. Accordingly, the latter can be used as corresponding emulsifiers in O / W emulsions and as solubilizers, while the nonethoxylated product is suitable as a W / O emulsifier or coemulsifier. In addition to their emulsifying properties, phytosterols can also be used positively on damaged or damaged skin, such as constitutional neurodermatitis or sunburn symptoms. In addition to the above-mentioned indication as emulsions, such products can also be used as hair rinses. The use of generol-containing shampoos can improve wet combability and hair shine. The cited literature accordingly describes W / O skin creams for dry skin, which, in addition to a conventional W / O emulsifier and various oil components, and consistency enhancers and stabilizers, contain 1% of Generol ^® 122 as a co-emulsifier. Furthermore, a hair conditioner is described there, which in addition to the cationic emulsion base and Consistency agents and additives have an oil component content, an O / W emulsifier and Generol ^® 122 in an amount of 1.0%. It is also found here that Generol ^® 122, in combination with longer-chain fatty acids, fatty alcohols or phospholipids, is able to build up multilamellar vesicles or layers. It is assumed that the phytosterols are deposited in the lamellar lipid layers. In contrast to Generol ^® 122, the ethoxylated Generol products are in a layer arrangement. If the water content is below 70%, lamellar phases are developed, but if the water content is increased to over 70%, a transition to multilamellar vesicles, i.e. liposomes, takes place. However, no surfactants may be present.

However, body cleansers contain a proportion of surfactants which are known (cf. DE-PS 42 05 548 and WO 92/04010) that they can have negative effects on the stability of liposomes, since liposomal structures are known to interact with surface-active substances aqueous solutions are solubilized.

US Pat. No. 5,688,752 describes cleaning and care compositions which, in addition to surfactants, have a combination of three components A, B and C in very specific molar ratios, where component A can be ceramides, phospholipids, pseudoceramides, glycolipids or polyethylene glycol esters, component B long-chain hydrocarbons with polar head groups such as fatty acids and component C are an auxiliary component for stabilizing any Bilayers that may have formed. Component C can be, for example, a 3-ß-sterol such as cholesterol, sitosterol, stigmasterol or ergosterol. Such products are intended to reduce the loss of lipids on the skin and thus dehydration. Active ingredients are not specified here as a mandatory component.

DE-198 54 827.3 describes vesicle-forming cleaning preparations on an aqueous basis for the first time, the liposomal structures forming spontaneously, ie without prior elaborate preparation or the presence of special vesicle formers and without a lipid phase. Sterols are used in addition to surfactants. In particular, it concerns the under the Generol® known products, which can also be ethoxylated. Either one or the other derivative or mixtures of ethoxylated and non-ethoxylated sterol are used. In the latter case, the share is in. ethoxylated product at least equal to, preferably higher than the proportion of non-ethoxylated sterol. However, if active substances are used, their proportion is limited and is at most 20%, preferably less. The preparation is made by preparing a solution of water and surfactants, heating it to the melting temperature of the sterols, melting them therein, then stirring the mixture cold and then, if necessary, other additives, auxiliaries and active ingredients at temperatures of 60 ° C incorporated up to 25 ° C.

Object of the present invention

The object of the present invention is therefore to formulate a surfactant-containing cleaning preparation which does not contain any fats, and yet has liposomal structures, in particular when used, whereby all the advantages of cleaning or skin care, as are known for surfactant-containing and lipid-containing products, are achieved and in which the active ingredient content is particularly high, so that a pronounced balneological effect can also be achieved.

Solution of the task

This object is achieved according to the invention by cleaning preparations containing 1 to 60% of one or more surfactants, which are selected in particular from anionic and / or nonionic and / or amphoteric and / or cationic surfactants, furthermore 0 to 25% additives, in particular 0.1 to 25%, especially 0.1 to 15% additives, 0 to 78%, preferably up to <78% water and which are characterized by a content of 21 to 50% of one or more active substances and a content of 0.001 to 15%, in particular 0.01 to 15%, especially 0.1 to 12%, very particularly preferably 0.2 to 10%, and in particular 0.2 to 5% of one or more non-ethoxylated sterol (s) or one or more non-ethoxylated sterols in a mixture with one or more ethoxylated sterols, the proportion of non-ethoxylated sterol (s) is higher than the proportion of ethoxylated (n)

Sterol (s).

The preparation can contain 0 to 78%, especially 0 to <78% water, in particular a content (or remainder) of water, preferably 0.1 to <78%, especially 1 to 60%, preferably 2 to 50%, in particular Have 3 to 40% and very particularly 5 to 30%.

Surprisingly, it could be shown that with such aqueous surfactant-containing preparations of the specified composition when used, liposomal structures arise spontaneously from the individual constituents and remain as such during the cleaning process, although contrary to the teaching of DE 198 54 827.3, the sterol / ethoxylated sterol ratio different and moreover the active ingredient percentage is higher. This is in stark contrast to known cleaning compositions, from which, as described above, when used in water, liposomes either form only from previously prepared particles or together with a fat phase and with a low active ingredient content.

With the new cleaning preparation, the loss of skin lipids caused by tensides during dirt removal as well as disturbance of the skin barrier function can be compensated for by the positive effect of sterols described above, especially in vesicular form. As a result, in addition to the excellent cleaning effect, drying out or irritation of the skin can be prevented. Surprisingly, it was not necessary to use fats or oil components for this purpose. In addition to the cleaning, an additional effect can be achieved through the use of active ingredients, e.g. Refreshment, revitalization, anti-stress, muscle relaxation, blood circulation promotion or balneological effects, e.g.

Relief of the common cold, calming, relieving rheumatic or circulatory complaints or skin irritation. A mixture of non-ethoxylated and ethoxylated sterol is preferably present.

In a preferred embodiment, the preparation according to the invention has 20 to 50% surfactant (s), 25 to 40% active ingredient (s), 0.5 to 5% sterol (not ethoxylated) or sterol mixture as described and 0.1 to 10% additives. Possibly. can also be water in suitable amounts as indicated or as

Rest be present.

The surfactant or surfactants are present in an amount of 1 to 60%. Particularly suitable amounts of surfactant are 5 to 55%, in particular 10 to 50% and very particularly preferably 20 to 50%, especially 30 to 50%.

The surfactant or surfactants are selected from one or more anionic, nonionic, amphoteric or cationic surfactants, with nonionic, anionic and amphoteric surfactants being particularly preferred. Also preferred is a mixture of one or more anionic, nonionic and amphoteric, in particular one or more nonionic (N) and amphoteric (AT) or one or more anionic

(A) and nonionic (N) surfactant (s).

Particular preference is given to one or more nonionic surfactant (s) (N) or a mixture thereof with anionic (A), amphoteric (AT) surfactants, an excess of nonionic surfactant (s) (N) being present in the mixture is.

It is also preferred, especially when only non-ethoxylated sterols are used, if the amount of nonionic surfactant is higher than that of the other surfactant (s) in these mixtures (A, AT, N or A, N; AT, N), a ratio of 10: 5: 5 to 100: 1: 1, in particular 5: 1: 1 to 30: 1: 1

Three mixtures (N, AT, A) or 10: 5 to 100: 1, in particular 5: 1 to 30: 1 at

Two mixtures (N, A; N, AT) are particularly preferred.

The sole use of nonionic surfactants in the stated amounts is particularly preferred, especially when using nonethoxylated sterols.

Anionic surfactants are known for the purpose described and can preferably be selected from alkyl sulfates (for example C10-C18) and / or the corresponding alkyl ether sulfates, in particular with 1-6 ethylene oxide groups in the molecule, sulfosuccinates, sulfosuccinamates, sarcosinates, isethionates, taurides, ether carboxylic acids , Protein-fatty acid condensates, alkyl sulfonates as well as alkylbenzenesulfonates, monoalkylphosphates, monoglyceride sulfates, amide ether sulfates, alkylsulfoacetates, α-olefin sulfonates. The alkyl chains in the surfactants mentioned can each comprise eight to eighteen carbon atoms. Are particularly preferred alkyl ether sulfates derived from fatty alcohols containing 12 to 18 carbon atoms and a degree of ethoxylation of 2 to 6, such as lauryl / myristyl, Na salt (example Texapon ^® K 14 S Special IS, Hansanol ^® NS 243), ammonium lauryl ether sulfate ( Zetesol ^® LA-2) or monoisopropanolammonium lauryl ether sulfate (Zetesol ^® 2056) or their mixtures such as Zetesol ^® 100 (MIPA-Laureth sulfate, Laureth-4, Cocamide DEA) or alkyl sulfates, e.g. sodium lauryl sulfate (Texapon ^® Z), ammonium lauryl sulfate (Texapon ^® ALS ) or monoisopropanolammonium lauryl sulfate (Sulfetal ^® CJOT 60). Also suitable are, in particular succinic acid derivatives, such as sulfosuccinates and sulfosuccinamates with an alkyl radical of 8 to 22 carbon atoms, for example WALLASOL ^® -L 29 (Disodium Laureth-3 Sulfosuccinate).

The amphoteric surfactant can in particular be selected from alkylaminopropionates, alkyl-, alkylamido- and sulfobetaines and alkylglycinates with a carbon chain length of C8 to C22. Particularly preferred is that known under the trade name Tego betaine ^® F50 or Dehyton ^® K cocamidopropyl.

The nonionic surfactant is especially selected from alkanolamides, e.g. Comperlan ^® 100 (Cocamide ^® MEA), Comperlan ^® KD (Cocamide DEA), fatty acid ethoxylates, e.g. Cremophor ^® RH 40 (PEG-40 Hydrogenated Castor Oil), fatty alcohol ethoxylates, e.g. Laureth-3 ( Volpo ^® L3), alkyl polyglucosides in particular with an alkyl radical of 8 to 16 carbon atoms, e.g. Plantacare ^® 2000 UP (decyl glucoside), sorbitan esters, e.g. Tween ^® 20 or 80 (Polysorbate 20 or 80), amine oxides, especially fatty amine oxides with a C7 to C26 Alkyl chain, e.g. Incromine Oxide ^® C30 (Cocamidopropylamine Oxide). Also suitable are alkylphenol oxyethylates (C8 - C22; possibly 4 to 20 ethylene oxide groups) or mixed condensates made of ethylene oxide and propylene oxide (eg Pluronics® types).

Suitable cationic surfactants are quaternary ammonium compounds with carbon chain lengths usually between 12 and 22, e.g. Steartrimonium chloride or pyridinium salts, e.g. Cetylpyridinium.

Particularly preferred surfactants from the group of anionic, amphoteric and nonionic surfactants are alkyl sulfate, alkyl ether sulfate, sulfosuccinate, sulfosuccinamate, sarcosinate, isethionate, tauride, ether carboxylic acid, protein fatty acid condensate, alkyl sulfonate as well as alkylbenzenesulfonate, monoalkyl sulfate sulfate, monoglyid sulfate, monoglyid sulfate, monoglyid sulfate, monoglycerophosphate, α-olefin sulfonate; Alkylaminopropionates, alkyl-, alkylamido-, sulfobetaines, alkylglycinates, alkanolamides; Fatty acid ethoxylates, fatty alcohol ethoxylates, alkyl polyglucosides, amine oxides, sorbitan esters, alkylphenol oxethylates, mixed condensates of ethylene oxide and propylene oxide.

Such surfactants suitable for cleaning agents are also described, for example, in SÖFW-Journal, 120th year, 2-3 / 94, pages 115 to 116, in issue 7/94, page 387 and in Cosmetics and Toiletries, vol. 108, 1993, p 83 - 89, as well as in SÖFW, 117 volume, No. 1 from 1991, pages 3 - 7 or in the monograph by K. Schrader, Basics and Recipes of Cosmetics, 2nd edition (1989, Hüthig Buchverlag), p. 683-691).

Particularly suitable sterols are phytosterols such as those obtained from corn oil, rapeseed oil, soybean oil, olive oil etc. and mainly, in addition to traces of other components, ß-sitosterol, campesterol, stigmasterol and / or brassicasterol in various known proportions by weight or mixtures thereof include, as described above and by RA Wächter (see p. 3.4 of this application). But it can also be the respective Individual components or two-component mixtures can be used in different proportions.

In particular, products made from soybean and rapeseed oil are preferred, a product obtained from soybean oil having in particular a mixture of sitosterol, campesterol and stigmasterol as main components and a product obtained from rapeseed oil preferably containing sitosterol, campesterol and brassikasterol as main components. Especially preferred are a phytosterol obtained from soybean or rapeseed oil, such as a product with the trade name Generol ^® 122 N (refined soyasterol) or Generol ^® R (rapeseed sterol).

Other suitable sterols include dihydrocholesterol or cholesterol esters such as cholesteryl acetate, or also - especially in a mixture with ethoxylated sterols - ergosterol and cholesterol. Dihydrocholesterol or cholesterol esters such as cholesteryl acetate are particularly preferred here.

Suitable ethoxylated sterols are ethoxylated derivatives of the sterols described above, especially the phytosterols mentioned (as mixtures as stated above or as individual components) of different origins, especially from olive oil, corn oil, rapeseed oil and soybean oil. These preferably have a degree of ethoxylation of 5 to 30, in particular 5 to 25. Preferred here are the ethoxylated phytosterols or said mixtures thereof, such as sold under the name Generol N 122 ^® E5D, E10, E16, E25D, and known from soy or analogously from rapeseed oil products obtained. Generol ^® RE5 with 5 EO units obtained from rapeseed oil is particularly preferred.

Also suitable are ethoxylated cholesterols of the type described with said degree of ethoxylation as especially ethoxylated dihydrocholesterol, in particular with 15 to 30 EO units, such as Nikkol ^® DHC-15 and -30 suitable. Particularly preferred are phytosterols, individually or as a mixture as described, namely 1) sitosterol, 2) campesterol, 3) stigmasterol, especially also 4) brassicasterol or mixtures thereof such as 1 + 2, 1 + 3, 1 + 4, 2 + 3 , 2 + 4, 1 + 2 + 3, 1 + 2 + 4, 1 + 3 + 4, 2 + 3 + 4, in the desired or known ratios given above, alone or together with the ethoxylated

Derivatives of the type specified, in particular with ethoxylated phytosterols or ethoxylated dihydrocholesterols or mixtures thereof as described, products obtained from rapeseed oil being particularly preferred.

As explained, according to the invention, either a sterol, in particular in combination with nonionic surfactants or high-proportion mixtures thereof with anionic and / or amphoteric surfactants, or else a sterol mixture, in combination with very high amounts of active ingredients from 21% to 50%, in particular 25 to 50%, especially 25 to 35% or 30 to 50%.

Particularly preferred sterols are phytosterols, e.g. from rapeseed oil or dihydrohholesterol, cholesterol acetate or mixtures thereof with the corresponding ethoxylated products.

Particularly preferred ethoxylated sterols are ethoxylated phytosterols and ethoxylated dihydrocholesterol or ethoxylated cholosterol acetate.

In addition, amounts of 0.2 to 8%, in particular 0.2 to 5% and preferably 0.5 to 4%, of sterol or the sterol mixture mentioned are particularly preferred.

A mixture of non-ethoxylated phytosterol, for example Generol ^® R and a 5-unit ethoxylated phytosterol, such as, for example, is very particularly preferred. B. Generol ^® RE5 or Generol ^® R alone, especially in an amount of 0.2 to 5%.

As mentioned, the proportion of non-ethoxylated sterol (s) in mixtures is higher than the proportion of ethoxylated (n) sterol (s), in particular the ratio of non-ethoxylated (s) to ethoxylated (s) sterol (s) ) 1, 5: 1 to 10: 1, preferably 2: 1 to 6: 1. A ratio of 3: 1 is particularly preferred.

All percentages relate to the weight of the mixture. As mentioned, the composition according to the invention contains a high level

Proportion of active ingredients, namely 21 to 50%, preferably 23 to 40%, in particular 25 to 35%. These active ingredients are selected in particular from

Extracts from plants, synthetically produced substances corresponding to these extracts and analog derivatives thereof, vitamins, and

Active ingredients and mixtures thereof influencing skin and hair.

Extracts from plants are, for example, those from ylang ylang, pine needles,

Cypress, thyme, mint, limes, oranges, grapefruit, tangerine,

Juniper, valerian, lemon balm, eucalyptus, thyme, palmarosa, rosemary, lavender, rosewood, spruce needle, pine needle, ginger,

Linden blossom, marigold, algae, aloe vera, echinacea, ivy leaf extracts or mixtures thereof.

These extracts can be made e.g. by steam distillation.

This will e.g. Obtain essential oils from the plants mentioned, which are particularly preferred.

The extracts can also be prepared in other known ways e.g.

Solvent extraction (with alcohols or hydrocarbons, water,

Mixtures thereof) obtained and then used as such.

Analog synthetically produced substances are, for example, terpenes and terpenoids such as camphor, menthol, cineol or mixtures thereof.

Vitamins A, E, C or suitable derivatives thereof are suitable as vitamins

Esters e.g. Palmitate, acetate or phosphate.

Skin or hair condition influencing and circulation-promoting as well as balneologically effective substances are for example panthenol, hydroxyethyl salicylate, nicotinic acid esters such as methyl nicotinate or also the above-mentioned terpenes and terpenoids, in particular cineol, menthol and

Camphor.

Depending on the intended effect, e.g. a balneological

Effect (eg cold relief, calming), improvement of the hair or skin structure, increased blood circulation, relaxation, aromatherapy, among other things, a suitable combination of active ingredients are added. Particularly preferred active ingredients are essential oils from ylang ylang, pine and spruce needles, eucalyptus, mint, oranges, grapefruit, lime, mandarin, cypress, thyme, lavender, rosemary, ginger, or mixtures thereof. These can also be combined with menthol, camphor, cineol, turpentine oil, ^• hydroxyethyl salicylate and methyl nicotinate.

Furthermore, above all the vitamins and / or panthenol mentioned are used, in particular in combination with the plant extracts or essential oils.

The composition according to the invention can also contain additives. These include dyes, conditioning agents, care agents, preservatives, odor correctors, stabilizers, consistency regulators, opacifiers or pearlescent agents, humectants. These can be present in particular in the following quantities: conditioning agent (s), e.g. 0.1 to 5%; Stabilizer (s), e.g. 0.1 to 5%, especially 0.5 to 3%, preservative (s), e.g. 0.01 to 5%, especially 0.1 to 2%; Consistency regulator (s), e.g. 0.01 to 5%; Care substances, e.g. 0.01 to 10%; Dyes, e.g. 0.0005 to 3% and opacifying agent (s), e.g. 0.01 to 5%; Olfactory corrections, e.g. 0.01 to 5%.

As care substances (for example, preferably 0.1 to 5%) of fatty acid glycerides such as Glyceryl Oleate (part of Lamesoft ^® PO 65, Lamesoft ^® TM Benz) are used and their ethoxylates, such as PEG-6 Caprylic / Capric Glycerides (Softigen ^® 767), PEG-7 glyceryl cocoate (Cetiol ^® HE). Also included are especially one or more lecithins or derivatives thereof such as in particular lecithin, phospholipids, such as phosphatidylcholine, and ceramides such as ceramide 2, -3, -6 and sphingolipids, such as Proceramide ^® L, Ceraderm ^® S, Ceraveg ^®. Lecithin (eg soy lecithin), phosphatidylcholine, phosphatidylserine or diethanolamine or mixtures thereof are particularly preferred. May further silicone oils such as dimethicones, or silicone .. - (co) polymers such as Dow Corning ^® 2220 HMW (Divinyldimethicone / dimethicone copolymer, C12-13 Pareth-3 C12-13 Pareth-23 /) are used.

As conditioning agents (for example preferably 0.1 to 3%) are cationic polymers such as polyquaternium-7, 10, 11, 22, 43 (e.g. Merquat ^® 280) or (hydroxypropyl) guar hydroxypropyl trimonium chloride (e.g. Cosmedia Guar ^® C261) , quaternized protein derivatives such as lauryldimonium hydroxypropyl hydrolyzed soy protein (part of Prota Flor ^® HSQ), silicone derivatives, e.g. Abil ^® B 8863, 8843 (dimethicone copolyol), protein hydrolysates or water-soluble proteins suitable, e.g. Promois ^® EFLS (Lauroyl hydrolyzed silk ( and) sodium salt), Promois ^® WK (Hydrolyzed Keratin), Promois ^® Milk (Hydrolyzed Casein), Wheat-Tein ^® AA (Hydrolyzed Wheat Protein), Lactolan ^® LS-5879 (Hydrolyzed milk protein).

As stabilizers (for example, preferably 0.1 to 5%) may, for example, complexing agents such as Trilon ^® BD (EDTA, sodium salt), means for adjusting the pH, eg citric acid, solvents such as propylene glycol or alcohols, inorganic salts such as sodium chloride or mixtures thereof be included. Glycerin, propylene glycol, sorbitol or polyethylene glycols are suitable as humectants.

In addition, one or more preservatives and consistency regulators (preferably for example 0.1 to 5% each) may also be present. Suitable preservatives are, for example, iodopropynyl butyl carbamate, phenoxyethanol and other customary preservatives, such as, for example, p-hydroxybenzoic acid ester, formaldehyde and releasers, sorbic and dehydroacetic acid and their salts, isothiazolinones, 5-bromo-5-nitro-1, 3-dioxane, methyldibromoglutanitrile , As consistency regulators (for example, preferably 0.1 to 5%) to Fettaikoholethoxylate are suitable, for example, Volpo ^® L 3 (Laureth-3), ethoxylated fatty acid or Glucoseester such as PEG-150 distearate, Glucamate DOE 120 ^® (PEG-120 Methyl Glucose Dioleates), fatty acid ethanolamides such as Comperlan ^® 100 (Cocamide MEA) or gelling agents such as acrylates, e.g. Carbopol ^® ETD 2020 (Acrylates / C 10-30 Alkyl Acrylate Crosspolymer) or Antil ^® 208 (Laureth-3, propylene glycol, acrylates / Steareth-50 copolymer ) or acrylamides, e.g. Sepigel ^® 305 (polyacrylamide C13-14 isoparaffin, Laureth-7) or polysaccharides such as Keltrol ^® (xanthan gum), cellulose derivatives such as hydroxypropyl methyl cellulose (Methocel ^® J12-MS) or silicates such as magnesium aluminum silicate ( Veegum ^® HV).

Suitable odor correctives (e.g. preferably 0.01 to 5%) are e.g. the essential oils mentioned under active ingredients or commercially available perfume mixtures.

The dyes (e.g. preferably 0.01 to 2%) are preferably the components known for generic products, such as Patent blue, amido blue, orange RGL, cochineal red, quinoline yellow.

The main pearlescent and opacifying agents are stearate dispersions such as Euperlan ^® PK 4000 (Glycol Distearate, Laureth-4, Cocamidopropyl Betaine), Euperlan ^® PK 1200 (Coco-Glucoside, Glycol Distearate, Glycerin, Aqua) or Euperlan ^® PK 3000 AM (Aqua, Glycol Distearate, Laureth-4, Cocamidopropyl Betaine, Formic Acid) as well as polymers such as Acusol ^® OP 301 (styrene / acrylates copolymer).

The type and amount of the additives depend on the desired form of use and the desired purpose. It is preferred if at most 25%, preferably 0.1 to 15%, especially also 0.1 to 10 or 1 to 10%, in particular 5 to 15%, of additives are present. Stabilizers, dyes, odor correctives, consistency regulators, care substances, optionally preservatives or mixtures are particularly preferred Of these, care substances and stabilizers are particularly preferred.

Cleaning preparations of the type described are very particularly preferred, in which care substances, in particular the glyceride derivatives described above or lecithins and derivatives thereof, are present as additives. Depending on requirements, other additives can then be added, especially dyes, stabilizers, consistency regulators. The selection of additives can be adapted to the desired application.

The cleaning compositions according to the invention are produced by preparing a mixture of the non-ethoxylated sterol and non-water-containing ingredients, such as such surfactants and additives and lipid-type active ingredients at room temperature up to 30 ° C, and if available, optionally with additives approx. 50 to 80 ° C first heated and cooled to approx. 30 ° C (s) ethoxylated sterol (s) at this temperature until room temperature (20 ° C) and then water and other water-containing ingredients such as surfactants, such Additives and active ingredients, if available, incorporated. In particular, it is preferred if a solution is first prepared from the non-ethoxylated sterol in non-water-containing active ingredients, such as, in particular, essential oils, the anhydrous surfactant (s) and lipophilic additives are added with stirring, then if ethoxylated sterols are present, at about 50 to 80 ° C the or the ethoxylated sterols in an additive, preferably selected from solvents, in particular propylene glycol or care substances such as Softigen® 767 (PEG-6 Caprylic / Capric Glycerides) dissolves and this solution is cooled to approx. 30 ° C , then stir this solution into the sterol solution (non-ethoxylated sterol) at this temperature up to room temperature (20 ° C) and then, if available, incorporate water and possibly other water-containing surfactants as well as additives and active ingredients. ^• The products obtained with the compositions according to the invention spontaneously form liposomal structures, in particular when used, in spite of the high active ingredient content. This can be done using.

Transmission electron microscopy (TEM) after freeze fracture can be detected.

With cleaning preparations of this type, it is thus possible to use products with existing or spontaneously forming liposomes and active ingredients as cleaning and care agents. These preparations are very easy to distribute. They have good cleaning properties, a pleasant feeling on the skin and favorable odor properties. So they meet the requirements for cosmetics. In addition, balneologically effective products can be manufactured.

The preparations can be used in particular as a foam bath, balneological, shower bath, washing gel or shampoo. Depending on the intended application, the individual components can be combined differently.

The products described also have very good stability and can be produced without the use of special and expensive equipment and production processes, as are usually required for the provision of liposomal preparations. The consistency of the products can be adjusted as desired using small amounts of additives and auxiliaries that do not change the feeling on the skin. Due to the special properties of sterols, especially phytosterols, namely that they have a positive effect on hair and skin properties as plant-based raw materials, a further care effect can be achieved in addition to the liposomal effect.

Surprisingly, it was found that in particular the presence of surfactants and high amounts of active ingredient (s) had no negative effect on the presence or formation of the liposomes. This could not be expected in view of the prior art already described, in which it was found that conventional liposomal structures are solubilized by such highly surface-active O / W emulsifiers or surfactants or, the active ingredient content is limited and, especially with sterol combinations, completely different conditions must be present.

By incorporating one or more of the above active ingredients e.g. Indicative bath and shower compositions can be produced according to the desired purpose. For example, a hardening bath with eucalyptus oil, mint oil and echinacea extract; a stimulating shower with rosemary oil and lime oil or a muscle relaxation bath with ginger extract, methyl nicotinate, hydroxyethyl salicylate and juniper oil or a cold bath with eucalyptus, pine needle and thyme oil and camphor.

Examples

The invention is illustrated by the following examples. Examples 1-5 represent the invention. Example 6 is a comparative composition according to the prior art. Following the examples, the transmission electron micrographs of the manufactured products are attached. Here you can clearly see the liposomal structures (spherical structures) in products produced according to the invention (Examples 1-5, Fig. 1-5) after dilution with water in a ratio of 1: 100 at 37 ° C, while in the comparison product (Fig. 6) no such structures are recognizable.

I. Production of cleaning preparations

The products according to the following examples were prepared by preparing a solution from the non-ethoxylated sterol in the specified essential oils, then adding the anhydrous surfactant (s) and lipophilic additives and active ingredients with stirring, and then, if appropriate, the separately prepared at approx. 80 ° C and cooled to approx. 30 ° C from the ethoxylated sterol in an additive (propylene glycol, Softigen ^® 767) and then, if available, water and possibly other water-containing surfactants as well as additives, auxiliaries and Active ingredients were incorporated. example 1

Example 2

Example 3

Example 4

Example 5

Example 6 (comparison)

Detection of the liposomal structures in the preparations according to the invention

In the following FIGS. 1-5, the liposomal structures (spherical structures) of the preparations according to Examples 1-5 are shown by transmission electron microscopy after freeze fracture. Furthermore, a picture according to comparative example 6 is attached (FIG. 6). As can clearly be seen here, with reverse sterol / ethoxylated sterol ratio according to DE 198 54 827.3 after dilution analogous to Examples 1 to 5, no liposomes are recognizable in the surfactant-containing composition.

List of TEM recordings

Example 1 No. 1 (ex.) Example 2 No. 2 (ex.) Example 3 No. 3 (ex.) Example 4 No. 4 (ex.) Example 5 No. 5 (ex.) Example 6 No. 6 (See.)

Claims

claims

1. Cleaning preparation containing 1 to 60% of one or more surfactants selected from anionic and / or nonionic and / or amphoteric and / or cationic surfactants, 0 to 25% additives, 0 to 78% .. water, characterized in that the Cleaning preparation 21 to 50% of one or more active ingredients and 0.001 to 15% of one or more non-ethoxylated sterol (s) or a mixture of one or more non-ethoxylated sterol (s) and one or more ethoxylated (n) Contains sterol (s), the

The proportion of non-ethoxylated sterol (s) is higher than the proportion of ethoxylated (n) sterol (s).

2. Cleaning preparation according to claim 1, characterized in that a mixture of one or more non-ethoxylated sterol (s) and one or more ethoxylated (n) sterol (s), the proportion of non-ethoxylated (n) sterol (s) is higher than the proportion of ethoxylated (n) sterol (s).

3. Cleaning preparation according to claim 2, characterized in that 0.1 to 25% additives are included.

4. Cleaning preparation according to one of claims 1 to 3, characterized in that the sterol or ethoxylated sterol is selected from phytosterols, selected from sitosterol, campesterol, stigmasterol,

Brassicasterol, dihydrocholesterol, cholesterol esters or cholesterol, ergosterol or derivatives or ethoxylated derivatives or mixtures thereof.

5. Cleaning preparation according to one of claims 1 to 4, characterized in that the ethoxylated sterol is one with a degree of ethoxylation of 5 to 30 (EO).

6. Cleaning preparation according to one of claims 1 to 5, characterized in that the weight ratio of non-ethoxylated (en) sterol (s) to ethoxylated (n) sterol (s) is 1.5: 1 to 10: 1.

7. Cleaning preparation according to one of claims 1 to 6, characterized in that the sterol contains ß-sitosterol, stigmasterol, campesterol, brassicasterol or mixtures thereof or their ethoxylated derivatives.

8. Cleaning preparation according to one of claims 1 to 7, characterized in that the surfactant contains one or more anionic, amphoteric or nonionic surfactants or mixtures thereof.

9. Cleaning preparation according to claim 8, characterized in that the surfactant is a nonionic surfactant, alone or in a mixture with anionic surfactant (s), amphoteric (s) surfactants, an excess of nonionic (s) surfactant ( en) is present.

10. Cleaning preparation according to one of claims 1 to 9, characterized in that it contains 5 to 55% of one or more surfactants.

11. Cleaning preparation according to one of claims 1 to 10, characterized in that it has a total of 0.2 to 5% of non-ethoxylated sterol and ethoxylated sterol.

12. Cleaning composition according to one of claims 1 to 11, characterized in that 0.1 to 15% additives are included.

13. Cleaning composition according to one of claims 1 to 12, characterized in that the additive (s) are selected from odor correctives, conditioning agents, preservatives, Stabilizers, consistency regulators, dyes, opacifiers or pearlescent agents, care agents, moisture retention agents or mixtures thereof.

14. Cleaning preparation according to one of claims 1 to 13, characterized in that one or more care substances selected from lecithin, phosphatidylcholine, sphingolipid and / or ceramide are contained in an amount of 0.01 to 5%.

15. Cleaning composition according to one of claims 1 to 14, characterized in that it contains 25 to 35% active ingredient (s).

16. Cleaning composition according to one of claims 1 to 15, characterized in that the active ingredient or ingredients are selected from extracts from plants, these extracts corresponding synthetically produced substances and analog derivatives thereof, vitamins, and skin and hair-influencing active ingredients and mixtures thereof.

17. Cleaning preparation according to claim 14, characterized in that extracts in the form of essential oils are contained as active ingredient (s). _,

18. A process for the preparation of a cleaning preparation according to one of claims 1 to 17, characterized in that a mixture of the non-ethoxylated sterol and non-water-containing ingredients, if present, is prepared at room temperature to 30 ° C, and then optionally the (the ) optionally with additive (s) while the ethoxylated sterol (s) is initially heated to 50 to 80 ° C and then cooled to approx. 30 ° C and then water and other water-containing ingredients, if present, are incorporated.

9. Use of cleaning preparations according to one of claims 1 to 17 as or for the production of bubble baths, balneologics, washing gels, shower baths or shampoos.