WO2004003010A3 - Nuclear hormone receptor ligano-binding domain containing protein - Google Patents

Nuclear hormone receptor ligano-binding domain containing protein Download PDF

Info

Publication number
WO2004003010A3
WO2004003010A3 PCT/GB2003/002807 GB0302807W WO2004003010A3 WO 2004003010 A3 WO2004003010 A3 WO 2004003010A3 GB 0302807 W GB0302807 W GB 0302807W WO 2004003010 A3 WO2004003010 A3 WO 2004003010A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding domain
hormone receptor
ligano
nuclear hormone
containing protein
Prior art date
Application number
PCT/GB2003/002807
Other languages
French (fr)
Other versions
WO2004003010A2 (en
Inventor
Christopher Benjamin Phelps
Richard Joseph Fagan
Janet Marjorie Allen
Kathryn Elizabeth Allen
Ilana Stancovski
Caroline Ann Hunt
Valerie Nathalie Pierron
Tom Phillips
Zinat Ellaheh Enayat
Original Assignee
Inpharmatica Ltd
Christopher Benjamin Phelps
Richard Joseph Fagan
Janet Marjorie Allen
Kathryn Elizabeth Allen
Ilana Stancovski
Caroline Ann Hunt
Valerie Nathalie Pierron
Tom Phillips
Zinat Ellaheh Enayat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharmatica Ltd, Christopher Benjamin Phelps, Richard Joseph Fagan, Janet Marjorie Allen, Kathryn Elizabeth Allen, Ilana Stancovski, Caroline Ann Hunt, Valerie Nathalie Pierron, Tom Phillips, Zinat Ellaheh Enayat filed Critical Inpharmatica Ltd
Priority to EP03761712A priority Critical patent/EP1530591A2/en
Priority to AU2003242848A priority patent/AU2003242848A1/en
Publication of WO2004003010A2 publication Critical patent/WO2004003010A2/en
Publication of WO2004003010A3 publication Critical patent/WO2004003010A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to a protein, termed hCP41042.2 (or LBDG7), herein identified as containing a novel Nuclear Hormone Receptor Ligand Binding Domain and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment.
PCT/GB2003/002807 2002-07-01 2003-07-01 Nuclear hormone receptor ligano-binding domain containing protein WO2004003010A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03761712A EP1530591A2 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor ligand-binding domain containing protein
AU2003242848A AU2003242848A1 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor ligano-binding domain containing protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0215228A GB0215228D0 (en) 2002-07-01 2002-07-01 Protein
GB0215228.8 2002-07-01

Publications (2)

Publication Number Publication Date
WO2004003010A2 WO2004003010A2 (en) 2004-01-08
WO2004003010A3 true WO2004003010A3 (en) 2004-02-26

Family

ID=9939657

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/002807 WO2004003010A2 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor ligano-binding domain containing protein

Country Status (4)

Country Link
EP (1) EP1530591A2 (en)
AU (1) AU2003242848A1 (en)
GB (1) GB0215228D0 (en)
WO (1) WO2004003010A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4848358B2 (en) * 2004-03-05 2011-12-28 ジルス−ラプ ゲーエムベーハー A method of performing at least one of enrichment or separation of prokaryotic DNA using a protein that specifically binds to DNA containing an unmethylated CpG motif

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOURGUET W ET AL: "Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 10, October 2000 (2000-10-01), pages 381 - 388, XP002255271, ISSN: 0165-6147 *
FAGAN R ET AL: "BIOINFORMATICS, TARGET DISCOVERY ANDTHE PHARMACEUTICAL/BIOTECHNOLOGY INDUSTRY", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON,, GB, vol. 2, no. 6, December 2000 (2000-12-01), pages 655 - 661, XP001007614, ISSN: 1464-8431 *
FUJINO TADAHIRO ET AL: "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 271, no. 2, 10 May 2000 (2000-05-10), pages 305 - 310, XP002262526, ISSN: 0006-291X *
JAN C ET AL: "Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 13, no. 6, 2000, pages 391 - 394, XP002959343, ISSN: 0269-2139 *
LEE JEONG-HEON ET AL: "Identification and characterization of the DNA binding domain of CpG-binding protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 48, 30 November 2001 (2001-11-30), pages 44669 - 44676, XP002262528, ISSN: 0021-9258 *
ROBINSON-RECHAVI M ET AL: "How many nuclear hormone receptors are there in the human genome?", TRENDS IN GENETICS, ELSEVIER, AMSTERDAM, NL, vol. 17, no. 10, 1 October 2001 (2001-10-01), pages 554 - 556, XP004328436, ISSN: 0168-9525 *
VOO KUI SHIN ET AL: "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 6, March 2000 (2000-03-01), pages 2108 - 2121, XP002262527, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
GB0215228D0 (en) 2002-08-14
EP1530591A2 (en) 2005-05-18
AU2003242848A8 (en) 2004-01-19
WO2004003010A2 (en) 2004-01-08
AU2003242848A1 (en) 2004-01-19

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