WO2003104481A3 - Method for designing pdk1 modulators - Google Patents

Method for designing pdk1 modulators Download PDF

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Publication number
WO2003104481A3
WO2003104481A3 PCT/GB2003/002509 GB0302509W WO03104481A3 WO 2003104481 A3 WO2003104481 A3 WO 2003104481A3 GB 0302509 W GB0302509 W GB 0302509W WO 03104481 A3 WO03104481 A3 WO 03104481A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
compound
dimensional structure
catalytic domain
pdk1
Prior art date
Application number
PCT/GB2003/002509
Other languages
French (fr)
Other versions
WO2003104481A2 (en
Inventor
Dario Alessi
Ricardo Biondi
David Komander
Aalten Daan Van
Original Assignee
Univ Dundee
Dario Alessi
Ricardo Biondi
David Komander
Aalten Daan Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee, Dario Alessi, Ricardo Biondi, David Komander, Aalten Daan Van filed Critical Univ Dundee
Priority to AU2003241038A priority Critical patent/AU2003241038A1/en
Priority to US10/517,225 priority patent/US7792665B2/en
Priority to EP03730356A priority patent/EP1513947B1/en
Priority to DE60313967T priority patent/DE60313967T2/en
Publication of WO2003104481A2 publication Critical patent/WO2003104481A2/en
Publication of WO2003104481A3 publication Critical patent/WO2003104481A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C43/00—Alloys containing radioactive materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Metallurgy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Materials For Photolithography (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method for selecting or designing a compound for modulating the activity of phosphoinositide dependent protein kinase 1 (PDKI), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the protein kinase catalytic domain of PDKI, wherein a three-dimensional structure or at least a part of the protein kinase catalytic domain of PDK1 is compared with a three-dimensional structure of a compound, and a compound that is predicted to interact with the said protein kinase catalytic domain is selected, wherein the three-dimensional structure of at least a part of the protein kinase catalytic domain of PDKI is a three-dimensional structure (or part thereof) determined for a polypeptide consisting of residues equivalent to residues 51 to 359 of full length human PKD1, or fragment or fusion thereof.
PCT/GB2003/002509 2002-06-08 2003-06-09 Methods WO2003104481A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003241038A AU2003241038A1 (en) 2002-06-08 2003-06-09 Method for designing pdk1 modulators
US10/517,225 US7792665B2 (en) 2002-06-08 2003-06-09 Method for designing a compound based on the three dimensional structure of phosphoinositide dependent protein kinase 1 (PDK1)
EP03730356A EP1513947B1 (en) 2002-06-08 2003-06-09 Method for designing pdk1 modulators
DE60313967T DE60313967T2 (en) 2002-06-08 2003-06-09 PROCESS FOR DEVELOPING PDK1 MODULATORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0213186.0A GB0213186D0 (en) 2002-06-08 2002-06-08 Methods
GB0213186.0 2002-06-08

Publications (2)

Publication Number Publication Date
WO2003104481A2 WO2003104481A2 (en) 2003-12-18
WO2003104481A3 true WO2003104481A3 (en) 2004-09-23

Family

ID=9938208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/002509 WO2003104481A2 (en) 2002-06-08 2003-06-09 Methods

Country Status (7)

Country Link
US (1) US7792665B2 (en)
EP (1) EP1513947B1 (en)
AT (1) ATE362993T1 (en)
AU (1) AU2003241038A1 (en)
DE (1) DE60313967T2 (en)
GB (1) GB0213186D0 (en)
WO (1) WO2003104481A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006020755A2 (en) * 2004-08-10 2006-02-23 Beth Israel Deaconess Medical Center, Inc. Methods for identifying inhibitors of the mtor pathway as diabetes therapeutics
US20110152166A1 (en) * 2006-08-18 2011-06-23 Ricardo M. Biondi Method of modulation of protein phosphorylation-dependent conformational transitions with low molecular weight compounds
EP2182058A1 (en) * 2008-10-17 2010-05-05 Universität des Saarlandes High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase PDK1
NZ620174A (en) 2009-09-16 2016-08-26 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
WO2011082285A1 (en) * 2009-12-30 2011-07-07 Avila Therapeutics, Inc. Ligand-directed covalent modification of protein
WO2011149874A2 (en) * 2010-05-26 2011-12-01 Schering Corporation N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
EP2865757A1 (en) 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA and their use in methods and compositions for inhibiting the expression of the PDK1 gene.
JP6709273B2 (en) * 2018-03-28 2020-06-10 公益財団法人福岡県産業・科学技術振興財団 Vapor deposition equipment

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041638A1 (en) * 1997-03-17 1998-09-24 Medical Research Council Phosphatidyl-3,4.5-triphosphate-dependent protein kinase
US5854992A (en) * 1996-09-26 1998-12-29 President And Fellows Of Harvard College System and method for structure-based drug design that includes accurate prediction of binding free energy
WO2000056864A2 (en) * 1999-03-19 2000-09-28 University Of Dundee Methods for altering substrate specificity of phosphoinositide-dependent-protein kinase 1 (pdk1)
WO2000070030A1 (en) * 1999-05-19 2000-11-23 Amgen Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
EP1096014A2 (en) * 1999-11-01 2001-05-02 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof
WO2001035316A2 (en) * 1999-11-10 2001-05-17 Structural Bioinformatics, Inc. Computationally derived protein structures in pharmacogenomics
WO2001044497A2 (en) * 1999-12-02 2001-06-21 University Of Dundee Protein kinase regulation
WO2001071347A1 (en) * 2000-03-23 2001-09-27 California Institute Of Technology Method and apparatus for predicting ligand binding interactions
WO2002022793A1 (en) * 2000-09-11 2002-03-21 Astex Technology Limited Crystal structure of pantothenate synthetase
US6387641B1 (en) * 1998-12-16 2002-05-14 Vertex Pharmaceuticals Incorporated Crystallized P38 complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE373676T1 (en) 1998-12-14 2007-10-15 Univ Dundee METHOD FOR ACTIVATING SGK BY PHOSPHORYLATION.
JP2002532100A (en) 1998-12-14 2002-10-02 メディカル リサーチ カウンシル Screening method
US20040137518A1 (en) * 2002-01-31 2004-07-15 Lambert Millard Hurst CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854992A (en) * 1996-09-26 1998-12-29 President And Fellows Of Harvard College System and method for structure-based drug design that includes accurate prediction of binding free energy
WO1998041638A1 (en) * 1997-03-17 1998-09-24 Medical Research Council Phosphatidyl-3,4.5-triphosphate-dependent protein kinase
US6387641B1 (en) * 1998-12-16 2002-05-14 Vertex Pharmaceuticals Incorporated Crystallized P38 complexes
WO2000056864A2 (en) * 1999-03-19 2000-09-28 University Of Dundee Methods for altering substrate specificity of phosphoinositide-dependent-protein kinase 1 (pdk1)
WO2000070030A1 (en) * 1999-05-19 2000-11-23 Amgen Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
EP1096014A2 (en) * 1999-11-01 2001-05-02 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof
WO2001035316A2 (en) * 1999-11-10 2001-05-17 Structural Bioinformatics, Inc. Computationally derived protein structures in pharmacogenomics
WO2001044497A2 (en) * 1999-12-02 2001-06-21 University Of Dundee Protein kinase regulation
WO2001071347A1 (en) * 2000-03-23 2001-09-27 California Institute Of Technology Method and apparatus for predicting ligand binding interactions
WO2002022793A1 (en) * 2000-09-11 2002-03-21 Astex Technology Limited Crystal structure of pantothenate synthetase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIONDI RICARDO M ET AL: "High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 21, no. 16, 15 August 2002 (2002-08-15), pages 4219 - 4228, XP002266843, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
GB0213186D0 (en) 2002-07-17
DE60313967T2 (en) 2008-01-17
AU2003241038A8 (en) 2003-12-22
US20050232804A1 (en) 2005-10-20
EP1513947A2 (en) 2005-03-16
DE60313967D1 (en) 2007-07-05
US7792665B2 (en) 2010-09-07
EP1513947B1 (en) 2007-05-23
AU2003241038A1 (en) 2003-12-22
WO2003104481A2 (en) 2003-12-18
ATE362993T1 (en) 2007-06-15

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