WO2003094831A2 - Novel diazabicyclic biaryl derivatives - Google Patents
Novel diazabicyclic biaryl derivatives Download PDFInfo
- Publication number
- WO2003094831A2 WO2003094831A2 PCT/DK2003/000295 DK0300295W WO03094831A2 WO 2003094831 A2 WO2003094831 A2 WO 2003094831A2 DK 0300295 W DK0300295 W DK 0300295W WO 03094831 A2 WO03094831 A2 WO 03094831A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- alkyl
- heterocyclic group
- disease
- monocyclic heterocyclic
- Prior art date
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- 0 CC1=CC(C)=N*1 Chemical compound CC1=CC(C)=N*1 0.000 description 13
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK03720288T DK1506200T3 (en) | 2002-05-07 | 2003-05-06 | Diazabicyclic biaryl derivatives |
DE60310548T DE60310548T2 (en) | 2002-05-07 | 2003-05-06 | DIAZABICYCLIC BIARYL DERIVATIVES |
JP2004502920A JP2005524713A (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclobiaryl derivatives |
MXPA04010966A MXPA04010966A (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclic biaryl derivatives. |
NZ535642A NZ535642A (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclic biaryl derivatives |
CA002480488A CA2480488A1 (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclic biaryl derivatives |
AU2003223927A AU2003223927B2 (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclic biaryl derivatives |
EP03720288A EP1506200B1 (en) | 2002-05-07 | 2003-05-06 | Diazabicyclic biaryl derivatives |
US10/513,398 US7300933B2 (en) | 2002-05-07 | 2003-05-06 | Diazabicyclic biaryl derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200200692 | 2002-05-07 | ||
DKPA200200692 | 2002-05-07 | ||
DKPA200201739 | 2002-11-11 | ||
DKPA200201739 | 2002-11-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003094831A2 true WO2003094831A2 (en) | 2003-11-20 |
WO2003094831A3 WO2003094831A3 (en) | 2004-01-15 |
Family
ID=29421783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2003/000295 WO2003094831A2 (en) | 2002-05-07 | 2003-05-06 | Novel diazabicyclic biaryl derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US7300933B2 (en) |
EP (1) | EP1506200B1 (en) |
JP (1) | JP2005524713A (en) |
CN (1) | CN1653068A (en) |
AT (1) | ATE348831T1 (en) |
AU (1) | AU2003223927B2 (en) |
CA (1) | CA2480488A1 (en) |
DE (1) | DE60310548T2 (en) |
DK (1) | DK1506200T3 (en) |
MX (1) | MXPA04010966A (en) |
NZ (1) | NZ535642A (en) |
WO (1) | WO2003094831A2 (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005028477A1 (en) * | 2003-09-19 | 2005-03-31 | Abbott Laboratories | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acety lcholine receptors |
WO2005070934A1 (en) * | 2004-01-14 | 2005-08-04 | Amgen Inc. | Substituted diazabicycloheptanes and their use as protein kinase inhibitors |
WO2006087305A1 (en) | 2005-02-16 | 2006-08-24 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
WO2006087306A3 (en) * | 2005-02-16 | 2006-11-23 | Neurosearch As | Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors |
WO2007038058A2 (en) * | 2005-09-23 | 2007-04-05 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
WO2007065892A1 (en) * | 2005-12-06 | 2007-06-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
US7354944B2 (en) | 2004-10-18 | 2008-04-08 | Amgen Inc. | Thiadiazole compounds and methods of use |
US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
WO2009050186A1 (en) * | 2007-10-18 | 2009-04-23 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
US7662812B2 (en) | 2005-02-16 | 2010-02-16 | Neurosearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors |
JP2011500624A (en) * | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 1,3,5-trisubstituted triazole derivatives |
US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
US7919504B2 (en) | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
US8143419B2 (en) | 2006-04-19 | 2012-03-27 | Janssen Pharmaceutica N. V. | Trisubstituted 1,2,4-triazoles |
US8779158B2 (en) | 2008-05-09 | 2014-07-15 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
US8778974B2 (en) | 2008-03-19 | 2014-07-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 triazoles |
WO2014116845A1 (en) * | 2013-01-23 | 2014-07-31 | Novartis Ag | Thiadiazole analogs thereof and methods for treating smn-deficiency-related-conditions |
US8884017B2 (en) | 2001-12-27 | 2014-11-11 | Bayer Intellectual Property Gmbh | 2-heteroarylcarboxylic acid amides |
US8987453B2 (en) | 2006-11-06 | 2015-03-24 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200534855A (en) * | 2004-01-13 | 2005-11-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
WO2005087236A1 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
WO2005094251A2 (en) * | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3muscarinic acetylcholine receptor antagonists |
EP2509982A1 (en) * | 2009-12-07 | 2012-10-17 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
ES2746850T3 (en) | 2010-05-17 | 2020-03-09 | Forum Pharmaceuticals Inc | Pharmaceutical formulations comprising crystalline forms of (R) -7-chloro-N- (quinuclidin-3-yl) benzo (b) thiophene-2-carboxamide monohydrate hydrochloride |
SG188307A1 (en) | 2010-09-23 | 2013-04-30 | Abbvie Inc | Monohydrate of an azaadamantane derivative |
MX358512B (en) | 2012-05-08 | 2018-08-24 | Forum Pharmaceuticals Inc | Methods of maintaining, treating or improving cognitive function. |
US11121404B2 (en) * | 2013-10-29 | 2021-09-14 | Lg Chem, Ltd. | Gel polymer electrolyte and lithium secondary battery comprising the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
WO2000034284A1 (en) * | 1998-12-04 | 2000-06-15 | Sanofi-Synthelabo | 2,5-diazabicyclo[2.2.1]heptane derivatives, their preparation and therapeutic uses |
WO2000044755A1 (en) * | 1999-01-29 | 2000-08-03 | Abbott Laboratories | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
WO2001090109A1 (en) * | 2000-05-25 | 2001-11-29 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
-
2003
- 2003-05-06 JP JP2004502920A patent/JP2005524713A/en active Pending
- 2003-05-06 AU AU2003223927A patent/AU2003223927B2/en not_active Ceased
- 2003-05-06 WO PCT/DK2003/000295 patent/WO2003094831A2/en active IP Right Grant
- 2003-05-06 CA CA002480488A patent/CA2480488A1/en not_active Abandoned
- 2003-05-06 DE DE60310548T patent/DE60310548T2/en not_active Expired - Lifetime
- 2003-05-06 CN CNA03810198XA patent/CN1653068A/en active Pending
- 2003-05-06 AT AT03720288T patent/ATE348831T1/en not_active IP Right Cessation
- 2003-05-06 NZ NZ535642A patent/NZ535642A/en not_active IP Right Cessation
- 2003-05-06 US US10/513,398 patent/US7300933B2/en not_active Expired - Fee Related
- 2003-05-06 DK DK03720288T patent/DK1506200T3/en active
- 2003-05-06 EP EP03720288A patent/EP1506200B1/en not_active Expired - Lifetime
- 2003-05-06 MX MXPA04010966A patent/MXPA04010966A/en active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
WO2000034284A1 (en) * | 1998-12-04 | 2000-06-15 | Sanofi-Synthelabo | 2,5-diazabicyclo[2.2.1]heptane derivatives, their preparation and therapeutic uses |
WO2000044755A1 (en) * | 1999-01-29 | 2000-08-03 | Abbott Laboratories | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
WO2001090109A1 (en) * | 2000-05-25 | 2001-11-29 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8884017B2 (en) | 2001-12-27 | 2014-11-11 | Bayer Intellectual Property Gmbh | 2-heteroarylcarboxylic acid amides |
US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
EP2316836A1 (en) * | 2003-09-19 | 2011-05-04 | Abbott Laboratories | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors |
WO2005028477A1 (en) * | 2003-09-19 | 2005-03-31 | Abbott Laboratories | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acety lcholine receptors |
US7872010B2 (en) | 2003-09-19 | 2011-01-18 | Abbott Laboratories | Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors |
WO2005070934A1 (en) * | 2004-01-14 | 2005-08-04 | Amgen Inc. | Substituted diazabicycloheptanes and their use as protein kinase inhibitors |
US7582631B2 (en) | 2004-01-14 | 2009-09-01 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
US7919514B2 (en) | 2004-10-18 | 2011-04-05 | Amgen Inc. | Thiadiazole compounds and methods of use |
US7354944B2 (en) | 2004-10-18 | 2008-04-08 | Amgen Inc. | Thiadiazole compounds and methods of use |
US7700636B2 (en) | 2004-10-18 | 2010-04-20 | Amgen Inc. | Thiadiazole compounds and methods of use |
US7750011B2 (en) | 2005-02-15 | 2010-07-06 | Neurosearch A/S | Diazabicyclic aryl derivatives and their medical use |
US7662812B2 (en) | 2005-02-16 | 2010-02-16 | Neurosearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors |
WO2006087306A3 (en) * | 2005-02-16 | 2006-11-23 | Neurosearch As | Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors |
WO2006087305A1 (en) | 2005-02-16 | 2006-08-24 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
WO2007038058A3 (en) * | 2005-09-23 | 2007-07-05 | Abbott Lab | Amino-aza-adamantane derivatives and methods of use |
US8586746B2 (en) | 2005-09-23 | 2013-11-19 | Abbvie Inc. | Amino-aza-adamantane derivatives and methods of use |
WO2007038058A2 (en) * | 2005-09-23 | 2007-04-05 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
EP2246352A1 (en) * | 2005-12-06 | 2010-11-03 | NeuroSearch AS | Novel diazabicyclic aryl derivatives and their medical use |
WO2007065892A1 (en) * | 2005-12-06 | 2007-06-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
CN101305004B (en) * | 2005-12-06 | 2011-11-16 | 神经研究公司 | Novel diazabicyclic aryl derivatives and their medical use |
US8173658B2 (en) | 2005-12-06 | 2012-05-08 | Neurosearch A/S | Diazabicycylic aryl derivatives and their medical use |
US8143419B2 (en) | 2006-04-19 | 2012-03-27 | Janssen Pharmaceutica N. V. | Trisubstituted 1,2,4-triazoles |
US8987453B2 (en) | 2006-11-06 | 2015-03-24 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
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Also Published As
Publication number | Publication date |
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DK1506200T3 (en) | 2007-04-10 |
EP1506200A2 (en) | 2005-02-16 |
AU2003223927A1 (en) | 2003-11-11 |
EP1506200B1 (en) | 2006-12-20 |
ATE348831T1 (en) | 2007-01-15 |
US7300933B2 (en) | 2007-11-27 |
US20050131236A1 (en) | 2005-06-16 |
DE60310548T2 (en) | 2007-05-10 |
DE60310548D1 (en) | 2007-02-01 |
JP2005524713A (en) | 2005-08-18 |
CA2480488A1 (en) | 2003-11-20 |
CN1653068A (en) | 2005-08-10 |
NZ535642A (en) | 2006-10-27 |
WO2003094831A3 (en) | 2004-01-15 |
AU2003223927B2 (en) | 2009-12-17 |
MXPA04010966A (en) | 2005-01-25 |
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