WO2003092499A1 - Contact pour la detection d'informations biologiques - Google Patents
Contact pour la detection d'informations biologiques Download PDFInfo
- Publication number
- WO2003092499A1 WO2003092499A1 PCT/JP2003/005297 JP0305297W WO03092499A1 WO 2003092499 A1 WO2003092499 A1 WO 2003092499A1 JP 0305297 W JP0305297 W JP 0305297W WO 03092499 A1 WO03092499 A1 WO 03092499A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- contact
- biological information
- lip
- light
- measurement
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6843—Monitoring or controlling sensor contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
Definitions
- the present invention relates to a biological information measuring device and the like for non-invasively measuring biological information such as blood glucose level and cholesterol of a living body by transmitted light, reflected light, scattered light or transmitted reflected light.
- Diabetes is often free of subjective symptoms, and 45% of highly suspected individuals are currently being treated for diabetes. Diabetes is a scary disease with many deaths due to complications, but it is not widely understood that it is a serious illness because blood sugar levels are high only at the beginning and there are no subjective symptoms. For this reason, it is said that the biggest problem of diabetes is that if you review your lifestyle, you will miss the stage where you can survive.
- Severely ill patients with diabetes have their own blood sampling type blood glucose meter that is easy to operate and use their own method to collect blood and measure blood glucose, but they are aware that the possibility of diabetes cannot be ruled out People who have no symptoms or healthy people who are not likely to have diabetes are less interested in blood sugar levels, and even if they are interested in blood sugar levels, they have a painful self-collecting blood glucose meter and have a habitual practice. They do not try to measure. Therefore, in recent years, a device for non-invasively measuring the blood glucose level of a subject has been proposed. For example, an ATR (Attenuated Total Reflection) prism is used.
- the ATR prism is used as a method of analyzing the light that is repeatedly attenuated and totally reflected at the boundary between the prism reflection surface and the living body, and then emitted outside the prism.
- There has been proposed a method of measuring by sandwiching them for example, see Japanese Patent Application Laid-Open No. 9-113439.
- This method applies evanescent waves (so-called leaching light) to quantitative analysis.
- evanescent waves so-called leaching light
- FIG. 13 shows that light 53 propagating through the optical fiber 54 and traveling through the ATR prism 51 slightly enters the lip 52 and then is reflected. Therefore, the light 53 penetrates into the lip 52 and is affected by each component in the body fluid present therein.Therefore, by measuring the amount of reflected light, it is possible to detect changes in the reflectance, absorptivity, etc. of the body fluid. It will be possible to obtain information on each component in it.
- the entire disclosure of the above-mentioned Japanese Patent Application Laid-Open No. 9-113439 is incorporated herein by reference in its entirety.
- the conventional measuring device as described above has the following problems.
- the incident angle is 45 degrees
- the surrounding medium is water (refractive index).
- Figure 14 shows an example of a spectrum of a measured lip.
- the shape of the spectrum varies greatly depending on the measurement site, such as the tip of the lip, approximately the center of the lip, and the back of the lip, and the information included is analyzed as the same. Is too big.
- Fig. 15 (a) shows an example of a spectrum obtained by measuring water
- Fig. 16 shows an enlarged view of a part of this spectrum.
- the spectral shape changes as shown in Fig. 15 (d). I have.
- the intervening air layer is also a factor of variation.
- FIG. 17 shows a partially enlarged example of the spectrum of the lip 52, which is measured by using a clip-shaped pressing member incorporating an elastic body such as a panel in order to make the lip 52 adhere to the lip.
- the measurement was performed three times continuously with the ATR prism 51 and the ATR prism 51 adhered to each other. It can be said that the spectrum fluctuates from the first time to the third time, and it can be said that the thickness of the saliva layer changes.
- This change in the saliva layer is caused by the j-pressure applied to the soft lip 52 only by the elastic force. This is a phenomenon that occurs because the pressing force is gradually changing, and this is a factor that causes variation.
- the ATR prism 51 is sandwiched between the lips 52 and When applying, the degree of adhesion changes depending on the force of closing the lips 52, the adhesion between the surface of the ATR prism 51 and the lips 52 is not stable, and it is difficult to control the thickness of the saliva layer, and the air layer Variations are likely to occur in the measurement data due to the influence of the presence of intervening elements.
- the mucous membrane of the lip has minute irregularities, and if the adhesion is insufficient, the air layer will intervene.
- an object of the present invention is to provide a biological information measuring method and an apparatus that can easily perform close contact between a prism and an object to be measured and position reproducibility and perform highly accurate measurement. I do.
- a first aspect of the present invention provides a first contacting means having a contacting surface that contacts a measurement site of a subject
- Fixing means for fixing the contact surface so as not to move on the measurement site
- the contact surface an emission region for emitting light to the measurement region, and all or a part of transmitted light, reflected light, scattered light, or transmitted reflected light from the measurement region based on light emitted from the emission region.
- This is a biological information detecting contact device having an incident area for incident light.
- the biological information detecting contact device according to the first aspect of the present invention, further comprising a deforming unit configured to deform at least a part of the subject so that the measurement site can contact the contact surface. It is.
- the subject is a lip of a living body, and the measurement site is a lip mucosa of the lip,
- the deforming means is a contact device for detecting biological information according to a second aspect of the present invention, which deforms the lip so as to expose the lip mucosa to the outside.
- a fourth aspect of the present invention is the biological information detecting contact device according to the third aspect of the present invention, wherein the deforming means is held in the oral cavity of the living body, and has a push-opening means for moving outside the teeth from the gingiva to the lower lip girdle. It is. ⁇
- the fixing means includes a mounting portion which is bitten by upper and lower teeth in an oral cavity of the living body,
- the first contacting means is disposed outside the dentition, and the contact surface is brought into close contact with the labial mucosa by occluding the mounting portion by the upper and lower teeth. It is a contact device for detection.
- a sixth aspect of the present invention is the biological information detecting contact device according to the third aspect of the present invention, wherein the deforming means has a holding means for holding the lip at at least one place.
- a seventh aspect of the present invention is the biological information detecting contact device according to the sixth aspect of the present invention, wherein the holding means is configured to rotate around a labial groove or a lower part of the labial groove.
- the fixing means holds the first abutting means, moves in conjunction with the rotation of the holding means, and abuts the abutting surface on the lip.
- a seventh aspect of the present invention is a contact device for detecting biological information, the contact device having a holding means for making contact.
- the subject is a living body
- the biological information measuring apparatus wherein the fixing means performs the fixing by being supported by at least one of a dentition, a jaw, or a head of the living body.
- the tenth aspect of the present invention further includes a second contacting means facing the first contacting means with the measurement part interposed therebetween and contacting a part of the subject different from the measurement part, .
- the fixing means is the biological information detecting contact device according to the first aspect of the present invention, which fixes the first contact means and the second contact means so as to maintain a constant distance between the first contact means and the second contact means.
- An eleventh aspect of the present invention is the contact device for detecting biological information according to the tenth aspect of the present invention, wherein the distance fixing means is capable of setting the fixed distance to a plurality of different sizes.
- the biological information detecting contact device according to the tenth aspect of the present invention, wherein the area of the contact surface is smaller than the area of a portion contacted by the second contact means.
- a thirteenth aspect of the present invention is the biological information detecting contact device according to the tenth aspect of the present invention, wherein said second contact means has a substantially convex shape.
- a fifteenth aspect of the present invention is the contact device for detecting biological information according to the thirteenth aspect of the present invention, wherein the convex shape has a rounded shape.
- a fifteenth aspect of the present invention is the tenth aspect of the present invention, further comprising a printing pressure measuring means for measuring a printing pressure on the measurement site by the first contacting means and Z or the second contacting means. It is a contact device for detecting biological information.
- a sixteenth aspect of the present invention is the biological information detecting contact device according to the fifteenth aspect of the present invention, wherein the distance fixing means changes the predetermined distance based on the measured printing pressure.
- a seventeenth aspect of the present invention provides the biological information detecting contact device according to any one of the first to sixteenth aspects,
- a biological information measuring device comprising: a calculating unit that calculates a light receiving result of the light receiving unit and obtains information on the measurement site.
- An eighteenth aspect of the present invention is the biological information measuring device according to the seventeenth aspect of the present invention, further comprising a confirmation means for confirming a portion deformed by the deformation means.
- a nineteenth aspect of the present invention is the biological information measuring apparatus according to the eighteenth aspect of the present invention, wherein the confirmation means is a contact confirmation by a contact sensor.
- a twenty-fifth aspect of the present invention is the body information measuring apparatus according to the eighteenth aspect of the present invention, wherein the contact confirmation uses an end of the push-opening means.
- a twenty-first aspect of the present invention is a dispersing unit that disperses light from the light source, a light guiding unit that guides light from the dispersing unit to the emission region,
- a biological information measuring apparatus comprising: a holder that integrally holds the light source, the spectral unit, the light guide unit, the light receiving unit, and the biological information detecting contact device. .
- a twenty-second invention is the biological information measuring apparatus according to the twenty-first invention, wherein the light guide means is a means using a mirror.
- a position regulating member is attached to the holder, and the position of the information detecting contact device is regulated by using the position regulating member. It is a biological information measuring device of the present invention.
- an emission region for emitting light to a measurement site of a subject, and transmitted light, reflected light, scattered light, or transmitted reflected light from the measurement site based on the light emitted from the emission region.
- the twenty-fifth aspect of the present invention is the biological information detecting method according to the twenty-fourth aspect of the present invention, further comprising a step of deforming at least a part of the subject so that the measurement site can abut on the abutment surface. is there.
- light is radiated by an information detection contact contacting a measurement site, and transmitted light, reflected light, scattered light, or transmitted reflected light from the measurement site is detected.
- a biological information measuring method for non-invasively measuring a specific component
- a twenty-seventh aspect of the present invention is the biological information measuring method according to the twenty-sixth aspect of the present invention, wherein the exposure of the lip mucosa is performed by moving a contact member in contact with the front surface of the lip in a chin direction.
- the method invention related to the present invention includes irradiating light with an information detection contact contacting the measurement site, and detecting transmitted light, reflected light, scattered light, or transmitted reflected light from the measurement site, and performing measurement.
- a biological information measuring method for non-invasively measuring a specific component in a site includes irradiating light with an information detection contact contacting the measurement site, and detecting transmitted light, reflected light, scattered light, or transmitted reflected light from the measurement site, and performing measurement.
- Disperse the light from the light source guide the dispersed light to the information detection contact, detect the transmitted light, reflected light, scattered light or transmitted / reflected light from the measurement site, and calculate the detected signal.
- There is a biological information measuring method for adjusting at least the position of the information detecting contact when obtaining biological information by performing the method.
- FIG. 2 (b) is a cross-sectional view of a usage image of the biological information measuring device according to the first embodiment of the present invention.
- (a) is a partial front sectional view of the biological information measuring device according to Embodiments 1 and 2 of the present invention.
- FIG. 4 is a partial external view of the biological information measuring device according to the second embodiment of the present invention.
- FIG. 6 is a use image diagram of the biological information measuring device according to the third embodiment of the present invention.
- Figure 7 shows (a) A partial detailed view of the biological information measuring device according to the third embodiment of the present invention.
- FIG. 8 is a diagram showing a partially enlarged biological information measuring device according to the third embodiment of the present invention.
- FIG. 9 is a diagram showing a partially enlarged spectrum obtained by measuring a living lip.
- Figure 10 shows
- FIG. 11 is a partial detailed view of the biological information measuring device according to the fourth embodiment of the present invention.
- FIG. 12 is an image of use of the biological information measuring device according to the fourth embodiment of the present invention.
- FIG. 13 is a schematic diagram showing an example of a conventional biological information measuring device.
- FIG. 14 is a graph showing a measurement spectrum of a conventional example.
- (b) is a diagram showing a state of water corresponding to a spectrum in a conventional example.
- (c) is a diagram showing a state of water corresponding to a spectrum in a conventional example.
- FIG. 16 is a diagram showing a partially enlarged spectrum of a conventional example in which water was measured.
- FIG. 17 is a view showing a partial enlargement of a spectrum of a conventional example in which a living lip is measured.
- FIG. 1 (a) and 1 (b) are sectional views of a use image of the biological information measuring device according to the first embodiment of the present invention
- FIG. 1 (c) is a front view of the use image
- FIG. 1 (d) is a use image
- Fig. 3 (a) is a partial sectional front view
- Fig. 3 (b) is an enlarged view.
- reference numeral 1 denotes a mouthpiece type biological information measuring device, which has a mounting portion 3 having a positioning recess 2 which is mounted along a lower incisor 10 and a lower lip 11 It consists of a measuring part 4 in contact.
- a prism 5 is built in the measuring section 4 so as to contact the lower lip 11 at the contact surface 5a, and light emitted from the light emitting element 6 passes through the prism 5 as shown by an arrow. The light advances and penetrates into the lower lip 11, which is the test object, through the emission area 500 a on the contact surface 5 a.
- the transmitted light, reflected light, scattered light or transmitted reflected light that has leached further travels through the prism 5 via the incident area 500 b on the contact surface 5 a and is detected by the light receiving element 7. Things.
- the light to be measured may include all of transmitted light, reflected light, scattered light, or transmitted and reflected light, or may be a part of the light.
- the electrical driving means of the measuring unit 4 such as the transmission to the light emitting element 6 and the transmission from the light receiving element 7 are not shown. Further, a configuration using a fiber as the information detection contact may be used. On the side where the lower lip 11 of the measuring section 4 comes into contact, a push-opening projection 8a for pushing and opening the lower lip 11 1 is formed.
- the operation of the mouthpiece-type biological information measuring device 1 according to the present embodiment having the above-described configuration is as follows.
- the positioning recess 2 provided in the mounting portion 3 of the mouthpiece type biological information measuring device 1 is mounted on the lower incisor 10.
- the positioning concave portion 2 of the mouthpiece type biological information measuring device 1 is still floating from the lower incisor 10 due to the elasticity of the lower lip 11. Then, when the mounting portion 3 is pressed by the upper incisor 13 as it is, the positioning recess 2 provided in the mounting portion 3 abuts on the lower incisor 10, and the push-opening projection 8 a is attached to the lower lip band 9 (lower side). Lowering the lower lip 1 1 1 by pushing it down to the lip and tendon that connects the gingiva) and lower lip 1 1 1 Transform 1 At that time, the mounting portion 3 is pressed and held by the upper incisors 13, so that the measuring portion 4 comes into close contact with the lower lip 11.
- the prism 5 built in the measuring section 4 is securely adhered to the lip mucosa 11 a of the lower lip 11.
- the mouthpiece type restricts the position of the prism 5 by the occlusion of the upper and lower teeth so that it does not move on the lip mucosa 1 1a. The position can be easily and reliably reproduced.
- a contact sensor is provided on the pushing-opening projection 8a on the gingival 12 side, and it is confirmed that the lip mucosa 11a on the gingival 12 side is correctly exposed by contacting the lower lip zone 9. If this is the case, the position can be reproduced more reliably.
- the contact confirmation by these contact sensors may be image confirmation by a micro CCD camera or the like.
- the mouthpiece is configured to be attached to the lower incisor 10, but may be configured to be attached to the entire lower dentition.
- the dentition is used as the positioning means, and the lip is pushed open by occlusion, It is only necessary to expose the measuring portion 4 and make the measuring portion 4 adhere closely.
- FIG. 2 (a) and 2 (b) are cross-sectional views of a usage image of the biological information measuring device according to the second embodiment of the present invention.
- 3 is a partial front sectional view
- (a) is a partial front sectional view
- 3 (b) is an enlarged view
- FIG. 4 is a partial external view of the biological information measuring device according to the second embodiment.
- reference numeral 21 denotes a biological information measuring device, which is a clip portion 22 for holding the lower lip 11 1, a measuring portion 23 for contacting the lower lip 11 1, and a jaw. It consists of a positioning table 24 on which 38 is placed, and a grip 25 that is held with one hand.
- the clip portion 22 includes an elastic member 26, a finger grip side 27, and a lip pinch side 28.
- An L-shaped member 39 is attached to the lower side of the clip portion 22, and the tip of the L-shaped member 39 is attached to a reference shaft 29 provided on the positioning table 24.
- the movable pin 31 is fixed to the reference pin 30 so as to be freely rotatable, and is fixed to the bent portion of the L-shaped member 39.
- the reference pin 30 is located near or below the labial sulcus 32.
- a guide plate 33 is rotatably suspended from the movable pin 31. Further, an elongated slide hole 34 formed in the center of the slide plate 33 is fitted to a guide pin 35 of the positioning table 24.
- the clip portion 22 having the L-shaped member 39 and the slide plate 33 are also arranged on the other side of the force measuring portion 23 (a part is drawn in FIG. 4). ing.
- the L-shaped members 39 are connected by the moving pins 31 as shown in FIG. Further, a holding part 23 a is fixed to the moving pin 31, and the measuring part 23 is held at an upper end of the holding part 23 a c
- the measuring section 23 incorporates a prism 5, a light emitting element 6, and a light receiving element 7 having a contact surface 5a.
- the light emitted from the light emitting element 6 travels through the prism 5 as shown by the arrow to the lower lip 11 which is the subject, and emits the emission area 5OOa on the contact surface 5a. Soak through.
- the transmitted light, reflected light, scattered light or transmitted reflected light after leaching further travels through the prism 5 through the incident area 500 b on the contact surface 5 a and is detected by the light receiving element 7. Things.
- the light to be measured may include all or some of transmitted light, reflected light, scattered light, or transmitted reflected light.
- the electric drive means of the measuring unit 4 such as the transmission to the light emitting element 6 and the transmission from the light receiving element 7 are not shown. Further, a configuration using a fiber as the information detection contact may be employed.
- the operation of the biological information measuring device 21 according to the present embodiment having the above-described configuration is as follows.
- the clip portion 22 fixed to the slide plate 33 turns around the reference pin 30 of the positioning table 24. It moves and goes down. Then, the lower lip 11 sandwiched by the clip portion 22 is deformed so as to be pulled downward together with the clip portion 22, and the lip mucosa 11 a, which is normally in contact with the gingiva 12, is moved out of the oral cavity. To be exposed.
- the measuring section 23 connected to the clip section 27 by the L-shaped member 39 is lowered downward in conjunction with the rotation of the clip section 27. This As a result, the contact surface 5a of the prism 5 is securely brought into close contact with the lip mucosa 11a of the lower lip 11.
- the method of moving the slide plate 33 may be manual or automatic using a combination of a motor and the like.
- the slide plate 33 is fixed and held in this state by a stopper (not shown), and is automatically or manually released from the stopper when the measurement is completed.
- the jaw position is regulated by the positioning table 24 and the reference axis 29, the three parts of the measuring unit 23, the clip unit 22, and the lower lip 11 are used. Are always the same if the user is the same person, and the reproducibility of the measurement position of the lower lip 11 measured by the measuring unit 23 can be performed very easily and reliably. is there.
- the prism 5 corresponds to the first contact means of the present invention
- the contact surface 5a corresponds to the contact surface of the present invention
- the emission area 500a corresponds to the present invention.
- the incident region 500b corresponds to the incident region of the present invention.
- the mounting part 3 and the measuring part 4, or the measuring part 23, the positioning stand 24, the slide plate 33, the moving pin 31, the reference pin 30 and the guide pin 35 correspond to the fixing means of the present invention.
- the part 22 corresponds to the holding means of the present invention.
- the lip mucosa 11a corresponds to the measurement site of the subject of the present invention.
- the push-opening projection 8a corresponds to the push-opening means of the present invention.
- the measuring section 4 of the mouthpiece-type biological information measuring device 1 has been described as including the light emitting element 6 and the light receiving element 7, but the light emitting element 6 and the light receiving element 7 are externally provided. It may be arranged so that light is transmitted by an optical fiber or the like.
- the mouthpiece-type biological information measuring device 1 corresponds to the biological information detecting contact device of the present invention, and the biological information detecting contact device can have a disposable configuration, which is safe for hygiene. It is.
- a pressing means for pressing the lower portion of the lower lip 11 so as to sandwich the measuring portion 23 will further increase the degree of adhesion. It is.
- the pressure of the measuring section 23 which is in close contact with the lower lip 11 can be confirmed, and the pressure can be automatically kept constant. .
- the clip portion 22 has a structure in which the center of the lip is opened, and has a structure sandwiching two places on both sides, but the clip portion 22 has a structure near the center of the lower lip 11.
- a structure in which only one place is sandwiched may be used.
- a structure sandwiching three or more places may be adopted. In short, any structure that can expose the lip mucous membrane by pulling the lip ⁇ ⁇ in between is sufficient.
- the grip 25 incorporates a drive circuit for measurement and a data storage circuit, etc., and switches 36 for starting measurement, driving a stopper, etc. and a display panel 37 on the surface of the grip 25 Is provided to display the measured data.
- the drive circuit for measurement, the data storage circuit, and the display panel may be provided outside the grip portion 25 instead of being built in, and the grip portion 25 may be used as a simple gripping device.
- the biological information measuring device 21 corresponds to the biological information detecting contact device of the present invention.
- the measuring section 23 is linearly moved downward from above.
- the measuring section 23 may be configured so as to make a fan-like rotation from an oblique direction and come into contact therewith. After the lip 11 is pulled, the measuring section 23 may be brought into contact with and pressed against the lip mucosa 11 a.
- positioning may be head regulation such as a headphone in addition to jaw regulation, or dentition regulation as in the first embodiment.
- head regulation such as a headphone in addition to jaw regulation, or dentition regulation as in the first embodiment.
- FIGS. 5 (a) and 5 (b) show another embodiment of the present invention, in which a lip cannot be pinched and a lower lip 11 which is slightly protruded from an upper lip is provided as a contact member, for example.
- the thin plate 41 is pressed against the lips so that it does not slip, and the thin plate is moved in the chin direction as shown by the arrow, so that the lower lip 11 that is in close contact with the thin plate 41 is similarly moved in the chin direction. It is pulled and exposes the lip mucosa 11a from the gums.
- the lower lip was described as the measurement site, but the lip mucous membrane of the upper lip may be measured as the measurement site.
- the device may be handled upside down, and the deforming means of the present invention exposes the upper lip to the outside and to the outside.
- the gist of the present invention is to reliably expose the body tissue such as the labial mucous membrane on the gingival side, which is normally hidden, and to make contact with and contact the contact means therewith, and to reliably perform the measurement position reproducibility. It is in.
- FIG. 6 is a use image diagram of the biological information measuring device according to the third embodiment of the present invention
- FIGS. 7A and 7B are partial detailed views of the biological information measuring device
- FIG. This is a vector example.
- reference numeral 61 denotes a desktop biological information measuring device, which has a measuring unit 5 having a prism 64 at its tip for contacting the lip mucosa 63 of the lower lip 62.
- a light source, and light guiding means for causing light from the light source to enter the prism 64 and permeate the labial mucosa 3, which is the subject to be brought into contact with, and then proceed further through the prism 64, Built-in detector for receiving light.
- FIG. 8 is an enlarged front view of the vicinity of the prism 64.
- the prism 64 has an incident end 81 on which light from a light source guided by the light guiding means is incident, and An emission end 82 from which transmitted light, reflected light, scattered light or transmitted reflected light is emitted after exuding into the lip mucosa 63, and an abutting surface 64a that directly contacts the lip mucosa 3 are formed.
- the optical fibers 81a and 82a are connected to the input end 81 and the output end 82, respectively.
- the other end of the optical fiber 81a is connected to a light source (not shown) and the optical fiber 82a.
- the other end of a is connected to a detector not shown.
- the light guide means may be a light guide by an optical system using a plurality of mirror surfaces instead of the optical fiber.
- the abutting portion 6a where the prism 64 abuts and senses the labial mucosa 63, which is a subject, has a small sensing area of less than half of the lip surface and protrudes from the surface of the measuring portion 65.
- the light exiting from the entrance end 8 1 and passing through the prism 64 exits to the lip mucosa 3 .
- the exit area 8 3 and the light exiting from the exit area 8 3 stain the lip mucous membrane.
- An incident area 84 into which transmitted light, reflected light, scattered light, or transmitted reflected light after being emitted is incident is included.
- the light to be measured may include all or some of transmitted light, reflected light, scattered light, or transmitted reflected light.
- An arithmetic circuit (not shown) is built in the desktop biological information measuring device 61, and receives and processes data from the measuring unit 65 to display it on a display unit 66 provided on the front or rear side. It is configured to display.
- the measuring part 65 has a lip support part 67 supporting the lips from below at one end.
- An auxiliary arm 69 having a moving gear rack 68 at the other end is slidably mounted. I have.
- a positioning lever 6 10 having a gear surface which meshes with the gear rack 68 of the auxiliary arm 6 9 is attached to the measuring section 6 ′ 5, and a stopper 6 is attached to the positioning lever 6 10.
- Lever fixing means by 11 and notch 6 10 a is provided.
- the positioning lever 610 may be manually operated by, for example, rotating manually, or may be automatically operated by an existing technology such as a motor or a gear mechanism. 297
- the lever fixing means may be an existing technique other than the stopper 611 and the notch 10a.
- the configuration may be such that the measurement start button can be operated when the positioning lever 610 is fixed, or the measurement is automatically started upon detecting that the positioning lever 610 is fixed. You may.
- the moving distance of the assisting arm 69 due to the rotation of the positioning lever differs from person to person as a subject, and differs for each subject, and is determined as follows. First, measure the thickness of the human lips to be measured. Next, the distance between the abutting portion 64a of the prism 64 and the lip supporting portion 67 is determined so as to be even smaller than the obtained thickness. For example, it is set to be 2 mm smaller than the measured thickness of the lips. Set the stopper 611 at the set position so that the positioning lever 610 does not rotate any further.
- the lip support part 67 has a size that is equal to or greater than the area of the contact part 64a, and has a slightly rounded convex surface.
- the height difference between the center and the end of the convex surface at this time shall be 0.5 mm or less.
- the lip 6 2 is inserted between the measuring section 65 and the auxiliary arm 69, the lip mucosa 63 is brought into contact with the prism 64, and the positioning lever 61 is rotated. Abut. By further rotating the positioning lever 6 10 until the stopper 6 11 restricts the lip support 6 7, the lip 6 2 is pressed against the prism and the lip mucosa 6 3 is on the sensing surface. Adhere to a certain contact part 6 4 a. At this time, the contact part between the lip support part 6 7 and the prism 4 Since the distance from the lip is set to be 2 mm narrower than the thickness of the lip, the lip is pressed and pressed, and comes into close contact with the contact portion 64 a by the elasticity of the lip itself. In addition, since the area of the contact portion 64a is smaller than that of the lip surface, the force applied to the pressing surface is concentrated, and the degree of adhesion increases.
- the lip support portion 67 is larger than or equal to the area of the contact portion 64a, so that the lip mucosa 63 in contact with the contact portion 64a is surely applied to the entire contact portion 64a. Can be pressed.
- the lip 62 eliminates the fine irregularities of the lips 62 by being pressed, thereby suppressing the air layer from intervening.
- the area of the pressure contact is small and slightly rounded, so that saliva on the lip mucosa 3 is located at the center of the contact portion 6 4a. This makes it easier for the abutment part 6 4 a and the lip support part 67 to escape to the area that is not pressed, and the variation of the salivary layer in the closely adhered lip mucosa 6 part is extremely small.
- the moving distance of the auxiliary arm 69 should be smaller than the lip thickness, but the dimension should be within the range of 0.5 mm or more and less than 5 mm. The appropriate amount is initially set according to the subject's lip elasticity and lip thickness Is what you do.
- the configuration may be such that the positioning lever position is temporarily stored as the lip position at the lip thickness position, and then, for example, is automatically slid by 2 mm after setting to zero.
- the lip support 67 is moved.
- a configuration in which the prism 64 is moved and pressed may be used.
- the movement of the lip support 67 or the prism 64 may be performed.
- the contact portion 64a of the lip support portion 67 and the prism 64 is pressed until it digs into the lip 62, and the lip mucous membrane 63 and the contact portion 64a come into close contact.
- the lip support portion 67 does not have to cut into the lip 62.
- the printing pressure may be such that the contact portion 64 a bites into the lip 62.
- the light From the light source through the light guide means and the prism 64, the light enters the lip mucosa 63 from the emission area 83 of the contact portion 64a, and is transmitted through the lip mucous membrane 63.
- Reflected light, scattered light or transmitted / reflected light enters from the incident area 84, is further received by the detector via the exit end 82, and the blood glucose level data obtained by the arithmetic circuit is displayed on the display unit of the device 61. 6 It is displayed on 6.
- this data is stored in a storage circuit so that past data can be arbitrarily extracted at any time.
- the positioning lever 6 10 is fixedly held by the stopper 6 11 and measurement is performed only in the fixed state.Therefore, there is no measurement due to unstable close contact during pressing, and stable pressing repeatability can be obtained. It is.
- the biological information measuring device is a desktop type, but may be a portable type.
- a pressure sensor corresponding to the printing pressure measuring means of the present invention may be incorporated in the inside of the lip support portion 67 to read the printing pressure at the time of pressing. This eliminates the need to measure the thickness of the subject's lips in advance, and quantitatively determines the distance between the lip support part 67 and the prism 64, so that the subject's close contact with the lip mucosa 63 is depressed. It is possible to perform a proper printing pressure.
- a power mechanism that operates based on the pressure of the pressure sensor may be provided to appropriately control the magnitude of the rotation of the positioning lever 610.
- FIG. 9 shows an example of a partially enlarged spectrum of the lips measured by the present embodiment. As in FIG. 7 shown in the conventional example, three consecutive measurements are performed while keeping the lips and the prism in close contact. It was done. A spectrum of almost the same shape was obtained from the first time to the third time. P Employee 97
- the prism 64 corresponds to the first contact means of the present invention
- the contact portion 64 a corresponds to the contact surface of the present invention
- the emission area 83 corresponds to the present invention.
- the incident area 84 corresponds to the incident area of the present invention.
- the lip support portion 67 corresponds to the second contact means of the present invention
- the auxiliary arm 69, the positioning lever 610, and the stopper 611 correspond to the distance fixing means of the present invention.
- the lip mucosa 63 corresponds to the measurement site of the subject of the present invention.
- the arithmetic circuit corresponds to the arithmetic means of the present invention, and the contact device for detecting biological information of the present invention comprises a prism 64, a lip support 67, a stopper 611, and a positioning lever 610. Correspond to what is done.
- the lip support portion 67 has a roundness 67 a, but this is for the purpose of preventing the lips from being damaged. It is also possible to provide a convex portion without corners.
- the contact device for detecting biological information according to the present invention can be implemented only with the prism 64, the lip support portion 67, the stopper 611, and the positioning lever 6110. May be implemented as a separate configuration.
- the contact device for detecting biological information can be configured in a disposable manner, so that sanitary safety can be improved.
- the description is made assuming that blood glucose level data is measured.
- the specific component of the present invention may be other data such as lipids and proteins. It can also be used to measure mucous membrane secretions, such as the lips and the mouth. These are the same in the first and second embodiments. (Embodiment 4)
- Fig. 10 (a) is a side sectional view of the biological information measuring device according to the fourth embodiment of the present invention
- Fig. 10 (b) is a front view of the biological information measuring device
- Fig. 11 is the biological information measuring device
- Fig. 12 is a schematic view of the information measuring device.
- reference numeral 101 denotes a tabletop biological information measuring device, and a measuring unit having a prism 104 at its tip which comes into contact with the lip mucosa 101 of the lower lip 104. 2 is built into the cradle 3. Note that the detailed configuration of the prism 104 is the same as in Embodiments 1 to 3, and a description thereof will be omitted.
- a light source 105 Inside the measuring section 102, a light source 105, an interferometer 106 that introduces and splits light from the light source 105, a light guide mirror 107, a detection mirror 108, and detection The container 109 is arranged.
- the inside of the interferometer 106 is composed of a beam splitter, a fixed mirror, and a movable mirror.
- Light enters the beam splitter and is split into two light beams, which are reflected by the fixed mirror and moving mirror, respectively, and returned to the beam splitter, where they are strengthened when they are in phase and weaker when they are out of phase.
- a strong and weak light having a phase difference due to the optical path difference is emitted, guided by the light guide mirror 107 to the prism 104 at the tip, and is brought into contact with the subject's lip After seeping into the mucous membrane 115, the light further advances in the prism 4 and is received by the detector 109 by the detecting mirror 108.
- the interferometer 6 is an example of the spectroscopic means of the present invention, other examples may include a grading type spectrometer that splits light by diffraction and an interference filter type spectrometer that limits a specific wavelength. .
- the measuring section 102 forms the holding body of the present invention, in which The optical system consisting of the light source 105, the interferometer 106, the light guide mirror 107, the prism 104, the detector mirror 108, and the detector 109 is all held together in the unit As a result, the optical axis and optical path length are always constant, and a stable signal can be obtained.
- a moving lever 10010 as a moving means for slidingly moving the measuring unit 102 itself is fixed to the measuring unit 102. 0 protrudes slidably.
- a foldable chin rest 101 as a position restricting member of the present invention is fixed to an end of the moving lever 101, and has a structure not shown but capable of adjusting the height. I have. Since the position is regulated by the chin rest 101, if the user is the same person, the measurement position can be easily and reliably reproduced on the labial mucosa 101, which is the measurement site.
- the sliding means may be, for example, a manual means of lifting by hand and hooking and fixing a lever to a stopper or a notch, or an automatic means operated by an existing technology such as a motor or a gear mechanism.
- the good c the cradle 1 0 3 even means incorporates arithmetic circuit 1 0 1 7, provided on the front surface receives and processes the data from the measuring unit 1 0 2 like circuit cable pull 1 8 It is configured to display on the display unit 102.
- the arithmetic circuit 101 may be provided in the measuring part 102.
- the operation of the desktop biological information measuring apparatus 101 according to the present embodiment having the above-described configuration is as follows.
- the measuring section 102 slides obliquely upward, and is fixed at that position by a stopper (not shown). Next, open and fix the folded chin rest 1 0 1 1. Then, place the chin 10 16 on the chin rest 101 1 and put the prism 104 on the lip mucosa 1 0 15 of the lower lip 100 4 so that the contact surfaces are in close contact with each other.
- this data is stored in a storage circuit so that past data can be arbitrarily extracted at any time.
- the measurement unit 102 is configured to be movable so that the measurement position can be easily measured only at the time of measurement, so that a small device that does not interfere with the table-top type that is installed on a table or desk can be provided. It can always be placed on the table like equipment. By doing so, you can easily measure anytime you notice, not just after a meal. In addition, since blood collection with pain is not required, measurement can be performed easily any number of times a day.
- the measurement unit 102 is configured to move obliquely upward.
- the measurement unit 102 may be configured to move in a straight direction, in other words, a measurement that abuts the lower lip 110 14. The person should be in a comfortable position. '.
- the measuring section 102 has a moving structure.
- the measuring section 102 may not be a moving structure but may be fixed to the cradle 3.
- the gist of the present invention is that the optical path length is changed. The objective is to obtain a stable signal with no propagation loss using an optical system with a constant optical axis.
- the configuration of the desktop biological information measuring device of the present embodiment may be implemented in combination with the biological information measuring devices of the first to third embodiments.
- the living body as the subject of the present invention is a human body and the measurement site is the lip mucosa. Oral cavity if it is necessary to contact It may be another part of the mucosa, such as the inner wall of the skin, gums, eyelids or genitals. It may be at any position on the human body.
- the living body of the present invention is not limited to humans, and may be an animal, and its body tissue may be used as the measurement site of the present invention.
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- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Audiology, Speech & Language Pathology (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2004-7002407A KR20040103898A (ko) | 2002-05-01 | 2003-04-25 | 생체정보 검출용 접촉장치 |
US10/486,010 US20040267166A1 (en) | 2002-05-01 | 2003-04-25 | Biological information detecting contact |
EP03723202A EP1500369A1 (en) | 2002-05-01 | 2003-04-25 | Biological information detecting contact |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002-129622 | 2002-05-01 | ||
JP2002129622 | 2002-05-01 | ||
JP2002-178448 | 2002-06-19 | ||
JP2002178448 | 2002-06-19 | ||
JP2002313234 | 2002-10-28 | ||
JP2002-313234 | 2002-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003092499A1 true WO2003092499A1 (fr) | 2003-11-13 |
Family
ID=29407513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/005297 WO2003092499A1 (fr) | 2002-05-01 | 2003-04-25 | Contact pour la detection d'informations biologiques |
Country Status (5)
Country | Link |
---|---|
US (1) | US20040267166A1 (ja) |
EP (1) | EP1500369A1 (ja) |
KR (1) | KR20040103898A (ja) |
CN (1) | CN1279874C (ja) |
WO (1) | WO2003092499A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006015155A (ja) * | 2004-07-02 | 2006-01-19 | Discus Dental Impressions Inc | 歯科用支持システム |
US8203700B2 (en) * | 2007-05-21 | 2012-06-19 | Ahura Scientific Inc. | Supporting remote analysis |
US7675611B2 (en) * | 2007-05-21 | 2010-03-09 | Ahura Scientific Inc. | Handheld infrared and Raman measurement devices and methods |
US8423112B2 (en) * | 2008-09-30 | 2013-04-16 | Covidien Lp | Medical sensor and technique for using the same |
JP5990905B2 (ja) * | 2011-12-19 | 2016-09-14 | ソニー株式会社 | 測定装置、測定方法、プログラム及び記録媒体 |
FR3016509B1 (fr) * | 2014-01-17 | 2018-03-30 | Apd Advanced Perfusion Diagnostics | Dispositif de mesure de donnees sanguines pour estimer la qualite de flux microcirculatoires |
KR102390874B1 (ko) * | 2014-10-29 | 2022-04-26 | 삼성전자주식회사 | 혈당 측정기 및 그에 따른 혈당 측정 방법 |
JP2020014769A (ja) * | 2018-07-27 | 2020-01-30 | セイコーインスツル株式会社 | 生体情報検出装置およびその製造方法、生体情報検出モジュールおよびその製造方法 |
JP7104939B2 (ja) * | 2018-07-27 | 2022-07-22 | セイコーホールディングス株式会社 | 生体情報検出装置およびその製造方法、生体情報検出モジュールおよびその製造方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07136151A (ja) * | 1993-05-07 | 1995-05-30 | Diasense Inc | 血液成分の濃度を検出する方法及び装置並びにこの装置を較正するための装置 |
JPH07308312A (ja) * | 1993-09-03 | 1995-11-28 | Ken Ishihara | 非侵襲血液分析装置とその方法 |
JPH10501141A (ja) * | 1993-04-12 | 1998-02-03 | イン‐ライン ダイアグノスティックス コーポレイション | 非侵入的にヘマトクリット値をモニタするシステム及び方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741213A (en) * | 1995-10-25 | 1998-04-21 | Toa Medical Electronics Co., Ltd. | Apparatus for analyzing blood |
US6113541A (en) * | 1997-03-07 | 2000-09-05 | Agilent Technologies, Inc. | Noninvasive blood chemistry measurement method and system |
US6285894B1 (en) * | 1997-03-25 | 2001-09-04 | Siemens Aktiengesellschaft | Method and device for non-invasive in vivo determination of blood constituents |
JP3758823B2 (ja) * | 1997-08-06 | 2006-03-22 | 倉敷紡績株式会社 | 生体の位置決め装置 |
-
2003
- 2003-04-25 WO PCT/JP2003/005297 patent/WO2003092499A1/ja not_active Application Discontinuation
- 2003-04-25 US US10/486,010 patent/US20040267166A1/en not_active Abandoned
- 2003-04-25 EP EP03723202A patent/EP1500369A1/en not_active Withdrawn
- 2003-04-25 KR KR10-2004-7002407A patent/KR20040103898A/ko not_active Application Discontinuation
- 2003-04-25 CN CNB038009005A patent/CN1279874C/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10501141A (ja) * | 1993-04-12 | 1998-02-03 | イン‐ライン ダイアグノスティックス コーポレイション | 非侵入的にヘマトクリット値をモニタするシステム及び方法 |
JPH07136151A (ja) * | 1993-05-07 | 1995-05-30 | Diasense Inc | 血液成分の濃度を検出する方法及び装置並びにこの装置を較正するための装置 |
JPH07308312A (ja) * | 1993-09-03 | 1995-11-28 | Ken Ishihara | 非侵襲血液分析装置とその方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1547451A (zh) | 2004-11-17 |
CN1279874C (zh) | 2006-10-18 |
EP1500369A1 (en) | 2005-01-26 |
US20040267166A1 (en) | 2004-12-30 |
KR20040103898A (ko) | 2004-12-09 |
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