WO2003086453A1 - Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis - Google Patents

Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis Download PDF

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Publication number
WO2003086453A1
WO2003086453A1 PCT/IT2002/000231 IT0200231W WO03086453A1 WO 2003086453 A1 WO2003086453 A1 WO 2003086453A1 IT 0200231 W IT0200231 W IT 0200231W WO 03086453 A1 WO03086453 A1 WO 03086453A1
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Prior art keywords
antigen
neuroaminidase
test
nay
subfragment
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PCT/IT2002/000231
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English (en)
French (fr)
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WO2003086453A9 (en
WO2003086453A8 (en
Inventor
Ilaria Capua
Stefano Marangon
Giovanni Cattoli
Original Assignee
Ilaria Capua
Stefano Marangon
Giovanni Cattoli
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Application filed by Ilaria Capua, Stefano Marangon, Giovanni Cattoli filed Critical Ilaria Capua
Priority to PCT/IT2002/000231 priority Critical patent/WO2003086453A1/en
Publication of WO2003086453A1 publication Critical patent/WO2003086453A1/en
Publication of WO2003086453A8 publication Critical patent/WO2003086453A8/en
Publication of WO2003086453A9 publication Critical patent/WO2003086453A9/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses
    • C12N2710/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses dsDNA Viruses
    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense
    • C12N2760/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense ssRNA Viruses negative-sense
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense
    • C12N2760/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense ssRNA Viruses negative-sense
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/11Orthomyxoviridae, e.g. influenza virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
PCT/IT2002/000231 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis WO2003086453A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP07015810A EP1980268A2 (en) 2002-04-12 2002-04-12 Vaccination methods against avian influenza virus
JP2003583471A JP2005538343A (ja) 2002-04-12 2002-04-12 ノイラミニダーゼをコードする精製サブフラグメント、組み換えノイラミニダーゼ、及び動物予防におけるその使用
CA002482244A CA2482244A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
EP02722692A EP1494708A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
AU2002253542A AU2002253542B2 (en) 2002-04-12 2002-04-12 Purified subfragment encoding neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
US10/511,229 US20060121447A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
IT000306A ITPD20020306A1 (it) 2002-04-12 2002-12-03 Subfragment purificato codificante per neuroaminidasi, neuroaminidasi ricombinanti e loro uso nella zooprofilassi.

Publications (3)

Publication Number Publication Date
WO2003086453A1 true WO2003086453A1 (en) 2003-10-23
WO2003086453A8 WO2003086453A8 (en) 2004-12-29
WO2003086453A9 WO2003086453A9 (en) 2005-04-14

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PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis

Country Status (7)

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US (1) US20060121447A1 (pt-PT)
EP (2) EP1980268A2 (pt-PT)
JP (1) JP2005538343A (pt-PT)
AU (1) AU2002253542B2 (pt-PT)
CA (1) CA2482244A1 (pt-PT)
IT (1) ITPD20020306A1 (pt-PT)
WO (1) WO2003086453A1 (pt-PT)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006041978A3 (en) * 2004-10-07 2006-08-03 Wyeth Corp Multivalent avian influenza vaccines
JP2008504839A (ja) * 2004-07-02 2008-02-21 ヘンリー, エル. ニーマン, コピーチョイス組換え及びその使用法
JP2008536526A (ja) * 2005-04-21 2008-09-11 アメリカ合衆国 イヌにおける呼吸器疾患管理のための材料および方法
WO2008115785A2 (en) * 2007-03-16 2008-09-25 Wyeth Multivalent avian influenza vaccines and methods
EP2161576A1 (en) * 2008-09-01 2010-03-10 Fujifilm Corporation Method of predicting risk of acquiring influenza
US9072701B2 (en) 2006-04-21 2015-07-07 St. Jude Children's Research Hospital Avian influenza viruses, vaccines, compositions, formulations, and methods
US10258686B2 (en) 2005-04-21 2019-04-16 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221362B1 (en) * 1996-07-19 2001-04-24 Merial Avian polynucleotide formula

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221362B1 (en) * 1996-07-19 2001-04-24 Merial Avian polynucleotide formula

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CAPUA LDARIA ET AL: "Strategies for the control of avian influenza in Italy.", THE VETERINARY RECORD. ENGLAND 16 FEB 2002, vol. 150, no. 7, 16 February 2002 (2002-02-16), pages 223, XP009004791, ISSN: 0042-4900 *
DATABASE EMBL [online] 15 December 1999 (1999-12-15), LEE M S ET AL: "Influenza A virus (A/chicken/Taiwan/7-5/99 (H6N1)) segment 6 neuraminidase gene, complete cds", XP002229091, retrieved from EMBL Database accession no. AF208598 *
JOHANSSON B E ET AL: "Immunogenicity of influenza A virus N2 neuraminidase produced in insect larvae by baculovirus recombinants", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 9, 1 June 1995 (1995-06-01), pages 841 - 845, XP004057540, ISSN: 0264-410X *
JOHANSSON B E: "Immunization with influenza A virus hemagglutinin and neuraminidase produced in recombinant baculovirus results in a balanced and broadened immune response superior to conventional vaccine", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 17, no. 15-16, 9 April 1999 (1999-04-09), pages 2073 - 2080, XP004165058, ISSN: 0264-410X *
PRICE P M ET AL: "COMPLEMENTATION OF RECOMBINANT BACULOVIRUSES BY COINFECTION WITH WILD-TYPE VIRUS FACILITATES PRODUCTION IN INSECT LARVAE OF ANTIGENIC PROTEINS OF HEPATITIS B VIRUS AND INFLUENZA VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 86, no. 5, 1 March 1989 (1989-03-01), pages 1453 - 1456, XP000008241, ISSN: 0027-8424 *
SUAREZ D L ET AL: "Immunology of avian influenza virus: A review.", DEVELOPMENTAL & COMPARATIVE IMMUNOLOGY, vol. 24, no. 2-3, March 2000 (2000-03-01), pages 269 - 283, XP002229027, ISSN: 0145-305X *
SUAREZ DAVID L: "Evolution of avian influenza viruses.", VETERINARY MICROBIOLOGY, vol. 74, no. 1-2, 22 May 2000 (2000-05-22), pages 15 - 27, XP002229029, ISSN: 0378-1135 *
SWAYNE D E ET AL: "Highly pathogenic avian influenza.", REVUE SCIENTIFIQUE ET TECHNIQUE OFFICE INTERNATIONAL DES EPIZOOTIES, vol. 19, no. 2, August 2000 (2000-08-01), pages 463 - 482, XP001122269, ISSN: 0253-1933 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008504839A (ja) * 2004-07-02 2008-02-21 ヘンリー, エル. ニーマン, コピーチョイス組換え及びその使用法
WO2006041978A3 (en) * 2004-10-07 2006-08-03 Wyeth Corp Multivalent avian influenza vaccines
KR101370464B1 (ko) 2004-10-07 2014-03-06 조에티스 더블유 엘엘씨 다가 조류 인플루엔자 백신
AP2167A (en) * 2004-10-07 2010-11-12 Wyeth Corp Multivalent avian influenza vaccines.
US8067013B2 (en) 2004-10-07 2011-11-29 Wyeth Llc Multivalent avian influenza vaccines
US10258686B2 (en) 2005-04-21 2019-04-16 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
JP2008536526A (ja) * 2005-04-21 2008-09-11 アメリカ合衆国 イヌにおける呼吸器疾患管理のための材料および方法
US9072701B2 (en) 2006-04-21 2015-07-07 St. Jude Children's Research Hospital Avian influenza viruses, vaccines, compositions, formulations, and methods
WO2008115785A2 (en) * 2007-03-16 2008-09-25 Wyeth Multivalent avian influenza vaccines and methods
WO2008115785A3 (en) * 2007-03-16 2009-01-29 Wyeth Corp Multivalent avian influenza vaccines and methods
EP2161576A1 (en) * 2008-09-01 2010-03-10 Fujifilm Corporation Method of predicting risk of acquiring influenza

Also Published As

Publication number Publication date
AU2002253542A1 (en) 2003-10-27
EP1980268A2 (en) 2008-10-15
EP1494708A1 (en) 2005-01-12
JP2005538343A (ja) 2005-12-15
US20060121447A1 (en) 2006-06-08
CA2482244A1 (en) 2003-10-23
AU2002253542B2 (en) 2007-06-07
WO2003086453A9 (en) 2005-04-14
WO2003086453A8 (en) 2004-12-29
ITPD20020306A1 (it) 2003-10-13

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