WO2003082396A1 - Multiport infusion device - Google Patents
Multiport infusion device Download PDFInfo
- Publication number
- WO2003082396A1 WO2003082396A1 PCT/GB2003/001377 GB0301377W WO03082396A1 WO 2003082396 A1 WO2003082396 A1 WO 2003082396A1 GB 0301377 W GB0301377 W GB 0301377W WO 03082396 A1 WO03082396 A1 WO 03082396A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- band
- multiport
- infusion device
- user
- port
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/223—Multiway valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0206—Holding devices, e.g. on the body where the catheter is secured by using devices worn by the patient, e.g. belts or harnesses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0213—Holding devices, e.g. on the body where the catheter is attached by means specifically adapted to a part of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0253—Holding devices, e.g. on the body where the catheter is attached by straps, bands or the like secured by adhesives
- A61M2025/026—Holding devices, e.g. on the body where the catheter is attached by straps, bands or the like secured by adhesives where the straps are releasably secured, e.g. by hook and loop-type fastening devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/082—Mounting brackets, arm supports for equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
Definitions
- the present invention generally relates to a multiport infusion device and, more particularly, to a device which reduces the risk of extravasation during the administration of intravenous fluids.
- the skin and vein of a patient can be damaged during the initial insertion of an intravenous needle.
- the skin and vein of a patient can be damaged after the procedure by moving the intravenous lines, movement of the patient or by many other known factors.
- the injury can be caused due to the repeated application and or removal and unintended or inadvertent pulling of the tubes and the like, as well. This, in turn, displaces the needle in relation to the punctured skin site, thus causing damage and injury to the patient.
- the typical site of such damage includes the hand or arm of the patient, for example.
- the tube from the reservoir is directly coupled to the extension tube which, in turn, is coupled to the needle of the catheter, itself.
- the intravenous catheter is secured to the patient's skin by an adhesive tape.
- a further safeguard is the creation of a 'loop' using part of the extended tubing circuit to form a loop and fixed to the skin by an adhesive tape. While the use of a loop can potentially reduce the risk of inadvertent pulls, it will not prevent such pulls and the needle may still be displaced by the movement of the patient or otherwise.
- the use of tapes to secure the tubing can, itself, damage sensitive skin at the point of skin puncture. Indeed, some skin conditions are highly vulnerable to minor trauma brought about by any manipulation.
- a multiport infusion device used as an intravenous administrator of prescribed fluid.
- the device includes a band adapted to be secured to a user's body part near an intravenous therapy location.
- a multiport body having at least two ports is further provided.
- the multiport body is secured to the band and includes a multiport fluid exchange route fluidly communicating between a first port and at least a second port.
- the band is a flexible band.
- the first port may accommodate an extension tube extending from a needle and the at least second port may accommodate an intravenous tube in fluid communication with the extension tube.
- the at least two ports may be three ports or more ports, each one of them may include a sealing cap.
- the band includes an adjustment mechanism, which may be a plurality of adjustment holes and a fastening device communicating with the adjustment holes.
- the band may lie flush with the skin, when in use; whereas the multiport body is raised from the band allowing air circulation between a tube extending from one of the at least two ports and the intravenous therapy location.
- the multiport infusion device in another aspect of the invention, includes a flexible band having a first end and a second end and adapted to be secured to a user's body part near an intravenous therapy location.
- a fastening device is positioned on the flexible band for fastening the flexible band to the user's body part.
- a main body has a three-way fluid exchange route, each route of the three way fluid exchange route has an opening port.
- the opening port has a sealing cap adapted to seal the port.
- the main body is raised from the flexible band allowing air circulation between a tube extending from one of the ports of the three-way fluid exchange route and the intravenous therapy location.
- the flexible band includes an adjustment mechanism including the fastening device. A plurality of adjustment holes along the flexible band may be provided for communicating with the fastening device.
- the flexible band may include means for preventing rotation of the band about the user when placed on the user.
- the multiport infusion device includes a band and means for providing fluid commumcation routes between an extension tube and at least another tube. Also included is means for preventing rotation of the band.
- Figure 2 shows an illustrative example of the present invention about a user's wrist.
- the present embodiment is directed to an intravenous device and, more particularly, to an intravenous device which reduces the risk of extravasation during the administration of intravenous fluids.
- the intravenous device is, in embodiments, a bracelet positioned about the limb or other body part of the user.
- a peripheral IV is inserted into the device and will act as a 'safe' buffer between the extension and reservoir tubes connected to an angiocath, for example.
- the intravenous device requires no modification to the currently used reservoir and extension tubes, nor do any known phlebotomy techniques need to be altered.
- the device prevents catheter displacements caused by pulls of the tubes secondary to a patient's position change or movements of the IV pole.
- the use of the intravenous device also directly reduces pressure exerted to the lines and reduces the risk of injuries caused by movements of the limbs or inadvertent displacement of the catheter. Additionally, disengagement and/or exchange of tubing system are greatly simplified.
- the device also provides additional infusion ports, allowing less manipulation of the tubing and potential dislodgment thereof.
- the intravenous device 10 includes a band 12, which may be made from a flexible and elastic type material to securely fit over a user's wrist or other portion of any limb or body part.
- the band 12 includes adjustment holes 14 communicating with a rivet type device, button or other fastening device 16 placed near or at an end of the band itself.
- Other fastening or coupling devices may equally be used in order to securely fit the intravenous device 10 on the user.
- a tension band or other device may be used.
- a body 18 having multiple ports 20, 22 and 24 in fluid communication with one another via fluid path 26 is provided on the band 10.
- the ports 22 and 24 are positioned substantially at a perpendicular angle to the port 20, and may include caps 22a and 24a, respectively, to seal the ports 22 and 24.
- the port 20 may also, in embodiments, have a sealing cap.
- the caps 22a and 24a are sealing the ports 22 and 24.
- the port 20 is preferably used for an extension tube 28 connected to an intravenous needle (not shown). In embodiments more or less than the two additional ports 22 and 24 is also contemplated.
- Figure 2 shows the band attached to a user's wrist.
- the adjustment mechanism securely fits the band 12 to the user's wrist and prevents rotation thereof.
- the body 18 is raised from the band allowing air circulation between the tube 28 extending from the port 20 and the intravenous therapy location. This prevents movement of any of the tubes, for example, tube 28 or dislodgment of the needle 28a.
- the cap 24a is open and the cap 22a remains closed, sealing the port 22.
- a tube may extend from the port 24 and would thus be in fluid communication with the tube 28 via the fluid communication path 26.
- the tube connected to the port 24 is used for infusion, as can be a tube connected to port 22.
- the tubes are isolatable from one another, i.e. can be unplugged individually from their respective ports.
- the device may conveniently be used to anchor any flexible connection made between an external device and a point of entry into a human or animal body.
- the device may be used to anchor naso-gastric tubes, urinary catheters and drain tubes such as chest drains.
- the term 'intravenous' as used in the description and claims of this application should, therefore, be construed in the broad sense of 'into the body'.
- the description describes the device as being secured 'to a user's body part'. It is clear that the intended use of the device is to prevent damage at the site of entry of the flexible connection into the body. Therefore, in some circumstances, such as where a patient is immobile, it may be equally appropriate to secure the device to a fixed point relative to the patient. Such a fixed point may conveniently be a chair or wheelchair in which a patient is sitting, or a bed in which a patient is lying. References to the term 'user's body part' in the description and claims should therefore be construed in the broad sense of a fixed point relative to the site of entry of a flexible tube into the patient's body.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003579926A JP2005521486A (en) | 2002-04-01 | 2003-03-28 | Multiport injection device |
EP03720666A EP1492588A1 (en) | 2002-04-01 | 2003-03-28 | Multiport infusion device |
AU2003224243A AU2003224243A1 (en) | 2002-04-01 | 2003-03-28 | Multiport infusion device |
US10/509,603 US7198616B2 (en) | 2002-04-01 | 2003-03-28 | Multiport infusion device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36856002P | 2002-04-01 | 2002-04-01 | |
US60/368,560 | 2002-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003082396A1 true WO2003082396A1 (en) | 2003-10-09 |
Family
ID=28675508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/001377 WO2003082396A1 (en) | 2002-04-01 | 2003-03-28 | Multiport infusion device |
Country Status (6)
Country | Link |
---|---|
US (1) | US7198616B2 (en) |
EP (1) | EP1492588A1 (en) |
JP (1) | JP2005521486A (en) |
CN (1) | CN1646184A (en) |
AU (1) | AU2003224243A1 (en) |
WO (1) | WO2003082396A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046786A1 (en) * | 2003-11-12 | 2005-05-26 | Gobat, Suministros Medicos, S.L. | Improved three-way valve |
WO2007031707A1 (en) * | 2005-09-16 | 2007-03-22 | Iden Shams | Infusion line stabiliser |
WO2014119979A1 (en) * | 2013-01-29 | 2014-08-07 | Aguirre Ramos José María | Holding strap for catheters |
WO2014190424A1 (en) | 2013-05-31 | 2014-12-04 | Burke Derryl | Intravenous line organizing system |
WO2017165275A1 (en) * | 2016-03-23 | 2017-09-28 | John Robinson | Medical component securement device |
EP3895755A4 (en) * | 2018-12-14 | 2022-08-31 | Servicio Andaluz de Salud | Anti-release connector for infusion lines |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2060283A1 (en) * | 2007-11-13 | 2009-05-20 | RoweMed AG - Medical 4 Life | Method for combining multiple infusions and/or injections |
WO2009105610A1 (en) * | 2008-02-22 | 2009-08-27 | Dale Medical Products, Inc. | Urinary catheter holder |
WO2009158145A2 (en) * | 2008-05-30 | 2009-12-30 | Allergan, Inc. | Injection device for soft-tissue augmentation fillers, bioactive agents and other biocompatible materials in liquid or gel form |
US8109912B2 (en) * | 2008-09-12 | 2012-02-07 | Calibra Medical, Inc. | Wearable infusion assembly |
BRPI0922629A2 (en) | 2008-12-02 | 2016-01-05 | Allergan Inc | injection device |
US20110137260A1 (en) | 2009-12-07 | 2011-06-09 | Allergan, Inc. | Slotted syringe |
EP2756857B1 (en) * | 2010-05-19 | 2016-05-18 | Allergan, Inc. | Modular injection device |
US8603028B2 (en) | 2011-11-18 | 2013-12-10 | Allergan, Inc. | Injection device having an angled tip portion |
US8747360B2 (en) * | 2011-12-07 | 2014-06-10 | Becton, Dickinston And Company | Adhesive backed IV catheter with auto release liner |
WO2014028463A1 (en) | 2012-08-14 | 2014-02-20 | Allergan, Inc. | Syringe for mixing and dispensing adipose tissue |
WO2014043718A1 (en) * | 2012-09-17 | 2014-03-20 | Laird Darrell Lynn | Intravenous line stabilization device and method |
US8672891B1 (en) * | 2013-03-14 | 2014-03-18 | Trenclasp LLC | IV line clasp |
US9044539B2 (en) * | 2013-03-14 | 2015-06-02 | Trenclasp, LLC | IV line clasp |
US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
CA2976544A1 (en) | 2015-03-10 | 2016-09-15 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
KR102232054B1 (en) | 2016-04-08 | 2021-03-26 | 알레간 인코포레이티드 | Suction and injection device |
USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
WO2018222671A1 (en) | 2017-05-30 | 2018-12-06 | Velano Vascular, Inc. | Stabilization devices for vascular access and methods of using the same |
MX2020005566A (en) | 2017-11-30 | 2020-08-20 | Velano Vascular Inc | Stabilizing connector devices for vascular access and methods of using the same. |
CN108578824A (en) * | 2018-06-14 | 2018-09-28 | 潍坊医学院 | It prevents from blocking after remaining needle tube sealing, the pump of thrombosis and its working method |
AU2019351151A1 (en) | 2018-09-28 | 2021-04-15 | Velano Vascular, Inc. | Devices and methods for phlebotomy through a closed system intravenous catheter |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US2449882A (en) * | 1947-02-08 | 1948-09-21 | Amy J Daniels | Holder for intravenous apparatus |
US3782382A (en) * | 1972-02-03 | 1974-01-01 | K N Enterprises Inc | Means for blood administration and the like |
US3939832A (en) * | 1973-03-09 | 1976-02-24 | Med-Pak Corporation | Liquid flow regulator and monitor for infusion system |
US4316461A (en) * | 1977-02-22 | 1982-02-23 | Marais Henri J | Intravenous vascular stabilizer |
US6086564A (en) * | 1998-07-27 | 2000-07-11 | Mclaughlin; David L. | Wrist-mounted I. V. administration set |
Family Cites Families (13)
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US2261213A (en) * | 1940-02-27 | 1941-11-04 | Bierman William | Syringe adapter |
US3782378A (en) * | 1972-10-12 | 1974-01-01 | S Page | Shield for intravenous feeding apparatus |
SE401785B (en) * | 1976-10-26 | 1978-05-29 | Viggo Ab | DEVICE AT AN INFUSION NEEDLE UNIT |
US4311137A (en) * | 1980-04-30 | 1982-01-19 | Sherwood Medical Industries Inc. | Infusion device |
US4666434A (en) * | 1983-10-21 | 1987-05-19 | Kaufman Jerry M | Catheter locating device |
US4586919A (en) * | 1984-04-06 | 1986-05-06 | Taheri Syde A | External shunt and method for procuring and preserving the endothelium of a vein used in arterial bypass |
US4846807A (en) * | 1986-04-30 | 1989-07-11 | Safadago Gary J | IV tube anchor and shield |
US5037398A (en) * | 1989-11-06 | 1991-08-06 | Buchanan Sharon J | Method and apparatus for releasably securing a pressure monitor device |
US5267967A (en) * | 1992-06-08 | 1993-12-07 | Hollister Incorporated | Retention device |
US5263943A (en) * | 1992-08-24 | 1993-11-23 | Vanderbrook Bernard E | Valved intravenous needle assembly |
AUPP676898A0 (en) * | 1998-10-26 | 1998-11-19 | Noble House Group Pty Ltd | Sampling first in blood collection |
US20020120231A1 (en) * | 2000-01-18 | 2002-08-29 | Douglas Joel S. | Subcutaneous injection set with secondary injection septum |
US6506181B2 (en) * | 2001-05-25 | 2003-01-14 | Becton, Dickinson And Company | Catheter having a low drag septum |
-
2003
- 2003-03-28 AU AU2003224243A patent/AU2003224243A1/en not_active Abandoned
- 2003-03-28 WO PCT/GB2003/001377 patent/WO2003082396A1/en active Application Filing
- 2003-03-28 JP JP2003579926A patent/JP2005521486A/en active Pending
- 2003-03-28 US US10/509,603 patent/US7198616B2/en not_active Expired - Fee Related
- 2003-03-28 EP EP03720666A patent/EP1492588A1/en not_active Withdrawn
- 2003-03-28 CN CN03807581.4A patent/CN1646184A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2449882A (en) * | 1947-02-08 | 1948-09-21 | Amy J Daniels | Holder for intravenous apparatus |
US3782382A (en) * | 1972-02-03 | 1974-01-01 | K N Enterprises Inc | Means for blood administration and the like |
US3939832A (en) * | 1973-03-09 | 1976-02-24 | Med-Pak Corporation | Liquid flow regulator and monitor for infusion system |
US4316461A (en) * | 1977-02-22 | 1982-02-23 | Marais Henri J | Intravenous vascular stabilizer |
US6086564A (en) * | 1998-07-27 | 2000-07-11 | Mclaughlin; David L. | Wrist-mounted I. V. administration set |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046786A1 (en) * | 2003-11-12 | 2005-05-26 | Gobat, Suministros Medicos, S.L. | Improved three-way valve |
US7914495B2 (en) | 2003-11-12 | 2011-03-29 | Gobat Suministros Medicos, S.L. | Three-way stopcock |
WO2007031707A1 (en) * | 2005-09-16 | 2007-03-22 | Iden Shams | Infusion line stabiliser |
WO2014119979A1 (en) * | 2013-01-29 | 2014-08-07 | Aguirre Ramos José María | Holding strap for catheters |
WO2014190424A1 (en) | 2013-05-31 | 2014-12-04 | Burke Derryl | Intravenous line organizing system |
US10583243B2 (en) | 2013-05-31 | 2020-03-10 | Derryl BURKE | Intravenous line organizing system |
WO2017165275A1 (en) * | 2016-03-23 | 2017-09-28 | John Robinson | Medical component securement device |
EP3895755A4 (en) * | 2018-12-14 | 2022-08-31 | Servicio Andaluz de Salud | Anti-release connector for infusion lines |
Also Published As
Publication number | Publication date |
---|---|
CN1646184A (en) | 2005-07-27 |
EP1492588A1 (en) | 2005-01-05 |
US20050131353A1 (en) | 2005-06-16 |
JP2005521486A (en) | 2005-07-21 |
US7198616B2 (en) | 2007-04-03 |
AU2003224243A1 (en) | 2003-10-13 |
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