WO2003078625A3 - An improved method for synthesising templated molecules - Google Patents

An improved method for synthesising templated molecules Download PDF

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Publication number
WO2003078625A3
WO2003078625A3 PCT/DK2003/000172 DK0300172W WO03078625A3 WO 2003078625 A3 WO2003078625 A3 WO 2003078625A3 DK 0300172 W DK0300172 W DK 0300172W WO 03078625 A3 WO03078625 A3 WO 03078625A3
Authority
WO
WIPO (PCT)
Prior art keywords
functional entity
templated molecules
attached
improved method
synthesising
Prior art date
Application number
PCT/DK2003/000172
Other languages
French (fr)
Other versions
WO2003078625A2 (en
Inventor
Henrik Pedersen
Anette Holtmann
Thomas Franch
Alex Haahr Gouliaev
Jakob Felding
Original Assignee
Nuevolution As
Henrik Pedersen
Anette Holtmann
Thomas Franch
Alex Haahr Gouliaev
Jakob Felding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/175,539 external-priority patent/US7727713B2/en
Priority claimed from PCT/DK2002/000419 external-priority patent/WO2002103008A2/en
Priority to NZ535144A priority Critical patent/NZ535144A/en
Priority to IL16382203A priority patent/IL163822A0/en
Priority to AU2003214031A priority patent/AU2003214031A1/en
Priority to EP03709676A priority patent/EP1487978B1/en
Priority to CA002518626A priority patent/CA2518626A1/en
Priority to DK03709676T priority patent/DK1487978T3/en
Application filed by Nuevolution As, Henrik Pedersen, Anette Holtmann, Thomas Franch, Alex Haahr Gouliaev, Jakob Felding filed Critical Nuevolution As
Priority to DE60324778T priority patent/DE60324778D1/en
Priority to JP2003576619A priority patent/JP4738741B2/en
Priority to US10/507,121 priority patent/US7413854B2/en
Priority to CN03809956XA priority patent/CN101006177B/en
Publication of WO2003078625A2 publication Critical patent/WO2003078625A2/en
Publication of WO2003078625A3 publication Critical patent/WO2003078625A3/en
Priority to US12/179,323 priority patent/US8808984B2/en
Priority to US14/340,123 priority patent/US10731151B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Abstract

The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
PCT/DK2003/000172 2002-03-15 2003-03-14 An improved method for synthesising templated molecules WO2003078625A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US10/507,121 US7413854B2 (en) 2002-03-15 2003-03-14 Method for synthesising templated molecules
CN03809956XA CN101006177B (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
DE60324778T DE60324778D1 (en) 2002-03-15 2003-03-14 AN IMPROVED METHOD FOR SYNTHESIS OF MATTRESS-RELATED MOLECULES
AU2003214031A AU2003214031A1 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
EP03709676A EP1487978B1 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
CA002518626A CA2518626A1 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
DK03709676T DK1487978T3 (en) 2002-03-15 2003-03-14 Improved method for synthesis of template molecules
NZ535144A NZ535144A (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
IL16382203A IL163822A0 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
JP2003576619A JP4738741B2 (en) 2002-03-15 2003-03-14 An improved method for synthesizing templated molecules.
US12/179,323 US8808984B2 (en) 2002-03-15 2008-07-24 Method for synthesising templated molecules
US14/340,123 US10731151B2 (en) 2002-03-15 2014-07-24 Method for synthesising templated molecules

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US36405602P 2002-03-15 2002-03-15
DKPA20020415 2002-03-15
DKPA200200415 2002-03-15
US60/364,056 2002-03-15
US38988502P 2002-06-20 2002-06-20
US10/175,539 US7727713B2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
US10/175,539 2002-06-20
DKPA200200952 2002-06-20
DKPA200200952 2002-06-20
DKPCT/DK02/00419 2002-06-20
PCT/DK2002/000419 WO2002103008A2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
US60/389,885 2002-06-20
US40996802P 2002-09-12 2002-09-12
DKPA200201347 2002-09-12
US60/409,968 2002-09-12
DKPA200201347 2002-09-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/175,539 Continuation-In-Part US7727713B2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10507121 A-371-Of-International 2003-03-14
US10/507,121 A-371-Of-International US7413854B2 (en) 2002-03-15 2003-03-14 Method for synthesising templated molecules
EP08169346.7A Previously-Filed-Application EP2186897B1 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules
US12/179,323 Continuation US8808984B2 (en) 2002-03-15 2008-07-24 Method for synthesising templated molecules

Publications (2)

Publication Number Publication Date
WO2003078625A2 WO2003078625A2 (en) 2003-09-25
WO2003078625A3 true WO2003078625A3 (en) 2004-01-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000172 WO2003078625A2 (en) 2002-03-15 2003-03-14 An improved method for synthesising templated molecules

Country Status (11)

Country Link
US (3) US7413854B2 (en)
EP (2) EP1487978B1 (en)
CN (1) CN101006177B (en)
AT (1) ATE414769T1 (en)
AU (1) AU2003214031A1 (en)
CA (1) CA2518626A1 (en)
DE (1) DE60324778D1 (en)
DK (1) DK1487978T3 (en)
IL (1) IL163822A0 (en)
NZ (1) NZ535144A (en)
WO (1) WO2003078625A2 (en)

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US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

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