WO2003076603A3 - Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions - Google Patents
Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions Download PDFInfo
- Publication number
- WO2003076603A3 WO2003076603A3 PCT/IB2003/001391 IB0301391W WO03076603A3 WO 2003076603 A3 WO2003076603 A3 WO 2003076603A3 IB 0301391 W IB0301391 W IB 0301391W WO 03076603 A3 WO03076603 A3 WO 03076603A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vesicles
- methods
- functionalization
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 238000007306 functionalization reaction Methods 0.000 title 1
- 230000002163 immunogen Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000030741 antigen processing and presentation Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03710146A EP1483372A2 (en) | 2002-03-14 | 2003-03-13 | Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
CA002479021A CA2479021A1 (en) | 2002-03-14 | 2003-03-13 | Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
US10/502,333 US20050042272A1 (en) | 2002-03-14 | 2003-03-13 | Vesiles derived from t cells, production and uses |
JP2003574810A JP2005528091A (en) | 2002-03-14 | 2003-03-13 | Functionalization of T cell-derived vesicles and their use to produce immunogenic pharmaceutical compositions |
AU2003214566A AU2003214566A1 (en) | 2002-03-14 | 2003-03-13 | Functionalization of T cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36384902P | 2002-03-14 | 2002-03-14 | |
US60/363,849 | 2002-03-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003076603A2 WO2003076603A2 (en) | 2003-09-18 |
WO2003076603A3 true WO2003076603A3 (en) | 2004-01-22 |
Family
ID=27805292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/001391 WO2003076603A2 (en) | 2002-03-14 | 2003-03-13 | Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050042272A1 (en) |
EP (1) | EP1483372A2 (en) |
JP (1) | JP2005528091A (en) |
CN (1) | CN1639323A (en) |
AU (1) | AU2003214566A1 (en) |
CA (1) | CA2479021A1 (en) |
WO (1) | WO2003076603A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1417229B1 (en) | 2001-08-17 | 2011-06-15 | Exothera L.L.C. | Methods and compounds for the targeting of protein to exosomes |
US7914792B2 (en) | 2003-02-14 | 2011-03-29 | Exothera L.L.C. | Methods and compounds for raising antibodies and for screening antibody repertoires |
ES2880460T3 (en) * | 2006-03-09 | 2021-11-24 | Aethlon Medical Inc | Extracorporeal removal of microvesicular particles |
CN101085349B (en) * | 2006-06-09 | 2011-05-25 | 项雯华 | Vesicle guiding immunocyte and application of the same in preparing antineoplastic medicine |
DK2094086T3 (en) * | 2006-11-08 | 2013-11-25 | Veritas Bio LLC | SUBMITTING IN VIVO OF DOUBLE-STRENGTH RNA TO A TARGET CELL |
CN102084000B (en) * | 2008-02-01 | 2016-03-16 | 总医院有限公司 | The purposes of microvesicle in the diagnosis of medical conditions and the patient's condition, prognosis and treatment |
FR2928926B1 (en) * | 2008-03-18 | 2015-08-21 | Centre Nat Rech Scient | CHIMERIC POLYNUCLEOTIDES AND POLYPEPTIDES FOR THE SECRETION OF A POLYPEPTIDE OF INTEREST IN ASSOCIATION WITH EXOSOMES AND THEIR USE FOR THE PRODUCTION OF IMMUNOGENIC COMPOSITIONS |
KR101314868B1 (en) * | 2009-07-01 | 2013-10-08 | 주식회사이언메딕스 | Microvesicles derived from mammalian nucleated cell and use thereof |
WO2011031892A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
FR2950350B1 (en) | 2009-09-24 | 2013-12-13 | Centre Nat Rech Scient | NOVEL POLYNUCLEOTIDES AND CHIMERIC POLYPEPTIDES FOR THE SECRETION OF A POLYPEPTIDE OF INTEREST IN ASSOCIATION WITH EXOSOMES AND USES THEREOF |
US20120315324A1 (en) * | 2010-02-05 | 2012-12-13 | University Of Louisville Research Foundation, Inc. | Exosomal compositions and methods for the treatment of disease |
JP5808349B2 (en) | 2010-03-01 | 2015-11-10 | カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー | Biomarkers for theranosis |
JP2013526852A (en) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | Circulating biomarkers for disease |
US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
WO2012064993A1 (en) | 2010-11-10 | 2012-05-18 | Exosome Diagnosties, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
EP3888640A1 (en) | 2013-06-05 | 2021-10-06 | AgeX Therapeutics, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
AU2017205637B2 (en) * | 2016-01-06 | 2023-01-05 | Health Research, Inc. | Compositions and libraries comprising recombinant T-cell receptors and methods of using recombinant T-cell receptors |
US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
EP3602066A1 (en) * | 2017-03-21 | 2020-02-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the transplantation-free survival time of patients suffering from cirrhosis |
WO2018183930A1 (en) * | 2017-03-30 | 2018-10-04 | Carson Dennis A | Methods for isolating, expanding and administering cancer specific cd8+ t cells |
CN108103026B (en) * | 2017-12-05 | 2020-12-22 | 四川省肿瘤医院 | Gamma-T cell exosome for tumor immunotherapy and preparation method thereof |
US20240091355A1 (en) * | 2019-10-11 | 2024-03-21 | Kyungpook National University Industry-Academic Cooperation Foundation | Composition, for prevention or treatment of cancer disease, comprising cytotoxic t cells activated by t helper cell-derived extracellular vesicles as active ingredient |
US20210198654A1 (en) * | 2019-12-26 | 2021-07-01 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | Method for isolation and harvesting microvesicles |
EP3933035A1 (en) * | 2020-07-03 | 2022-01-05 | Aarhus Universitet | Compositions comprising extracellular vesicles and sting stimulatory agents |
CN113265378A (en) * | 2021-06-16 | 2021-08-17 | 山东德升生物工程有限公司 | In-vitro amplification method for killing cells by using dual mechanism of activation of cell exosomes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001082958A2 (en) * | 2000-04-27 | 2001-11-08 | Anosys, Inc. | Methods of producing membrane vesicles |
-
2003
- 2003-03-13 EP EP03710146A patent/EP1483372A2/en not_active Withdrawn
- 2003-03-13 CN CNA038055333A patent/CN1639323A/en active Pending
- 2003-03-13 AU AU2003214566A patent/AU2003214566A1/en not_active Abandoned
- 2003-03-13 JP JP2003574810A patent/JP2005528091A/en active Pending
- 2003-03-13 WO PCT/IB2003/001391 patent/WO2003076603A2/en not_active Application Discontinuation
- 2003-03-13 CA CA002479021A patent/CA2479021A1/en not_active Abandoned
- 2003-03-13 US US10/502,333 patent/US20050042272A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001082958A2 (en) * | 2000-04-27 | 2001-11-08 | Anosys, Inc. | Methods of producing membrane vesicles |
Non-Patent Citations (2)
Title |
---|
DENZER, K. ET AL.: "Exosome: from internal vesicle of the multivesicular body to intercellular signaling device", JOURNAL OF CELL SCIENCE, vol. 113, no. 19, October 2000 (2000-10-01), pages 3365 - 3374, XP002225014 * |
MARTINEZ-LORENZO, M.J. ET AL.: "Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles", JOURNAL OF IMMUNOLOGY, vol. 163, no. 3, 1 August 1999 (1999-08-01), pages 1274 - 1281, XP002250995 * |
Also Published As
Publication number | Publication date |
---|---|
EP1483372A2 (en) | 2004-12-08 |
AU2003214566A1 (en) | 2003-09-22 |
WO2003076603A2 (en) | 2003-09-18 |
CN1639323A (en) | 2005-07-13 |
JP2005528091A (en) | 2005-09-22 |
US20050042272A1 (en) | 2005-02-24 |
CA2479021A1 (en) | 2003-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003076603A3 (en) | Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions | |
WO1999042564A3 (en) | Apoptotic cell-mediated antigen presentation to dendritic cells | |
WO2006066214A3 (en) | Use of flagellin in the immunotherapy of yersinia pestis | |
CA2330235A1 (en) | Antigenic complex comprising immunostimulatory peptide, cd4, and chemokine receptor domain for hiv treatment and immune disorders | |
EP2258386A3 (en) | Neisseria Vaccine composition | |
EP2181714A3 (en) | Immunogenic composition for use in vaccination against staphylococcei | |
CA2245497A1 (en) | Peptide immunogens for vaccination against and treatment of allergy | |
PT2351579T (en) | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages | |
WO2000062800A3 (en) | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide | |
CN103402539A (en) | A synthetic immunogen useful for generating long lasting immunity and protection against pathogens | |
US20100255033A1 (en) | Non-toxic double mutant forms of pertussis toxin as adjuvants | |
WO2001072277A3 (en) | Immunotherapeutic methods and compositions | |
CN113015541A (en) | Immunogenic peptides having novel oxidoreductase motifs | |
AU7460896A (en) | Composition and methods for enhancing immune responses mediated by antigen-presenting cells | |
WO2003004646A3 (en) | Genetic analysis of peyers's patches and m cells and methods and compositions targeting peyer's patches and m cell receptors | |
RU2019113989A (en) | MEDICINE | |
WO1999063945A3 (en) | Vaccination strategy to prevent and treat cancers | |
WO2001068677A3 (en) | Derivatives of breast canacer antigen her-2 for therapeutical use | |
NO875038L (en) | CONJUGATED VACCINE. | |
EP1655305A3 (en) | Therapeutic anti-cytomegalovirus compounds | |
CN113906046A (en) | Immunogenic peptides having an oxidoreductase motif comprising a modified cysteine | |
CA2273922A1 (en) | Novel saponin compositions and uses thereof | |
IL141996A0 (en) | Moraxella catarrhalis basb034 polypeptides and uses thereof | |
WO1999047102A3 (en) | Methods for enhanced antigen presentation on antigen-presenting cells and compositions produced thereby | |
WO2002030458A8 (en) | Yersinia adhesion protein as vaccine adjuvant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003710146 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003214566 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20038055333 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2479021 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003574810 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10502333 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2003710146 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2003710146 Country of ref document: EP |