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WO2003070749A3 - Self-assembly of peptide-amphiphile nanofibers under physiological conditions - Google Patents

Self-assembly of peptide-amphiphile nanofibers under physiological conditions

Info

Publication number
WO2003070749A3
WO2003070749A3 PCT/US2003/004779 US0304779W WO2003070749A3 WO 2003070749 A3 WO2003070749 A3 WO 2003070749A3 US 0304779 W US0304779 W US 0304779W WO 2003070749 A3 WO2003070749 A3 WO 2003070749A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
physiological
assembly
peptide
amphiphile
self
Prior art date
Application number
PCT/US2003/004779
Other languages
French (fr)
Other versions
WO2003070749A2 (en )
Inventor
Samuel I Stupp
Jeffrey D Hartgerink
Elia Beniash
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/705—Protein or peptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12014—All metal or with adjacent metals having metal particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24355—Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]
    • Y10T428/24372—Particulate matter
    • Y10T428/24413—Metal or metal compound

Abstract

Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
PCT/US2003/004779 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions WO2003070749A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US35722802 true 2002-02-15 2002-02-15
US60/357,228 2002-02-15

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2003/035902 WO2005003292A3 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles
US10534097 US7554021B2 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles

Publications (2)

Publication Number Publication Date
WO2003070749A2 true WO2003070749A2 (en) 2003-08-28
WO2003070749A3 true true WO2003070749A3 (en) 2004-04-01

Family

ID=27757587

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004779 WO2003070749A3 (en) 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions

Country Status (2)

Country Link
US (3) US7371719B2 (en)
WO (1) WO2003070749A3 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518876B2 (en) 2007-08-03 2013-08-27 PharmalN Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003054146A3 (en) * 2001-11-14 2004-04-01 Univ Northwestern Self-assembly and mineralization of peptide-amphiphile nanofibers
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
WO2003070749A3 (en) * 2002-02-15 2004-04-01 Univ Northwestern Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) * 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
WO2004046167A3 (en) 2002-11-14 2005-07-07 Claussen Randal C Synthesis and self-assembly of abc triblock bola peptide
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP2058275A1 (en) * 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
JP4837553B2 (en) * 2003-02-11 2011-12-14 ノースウエスタン ユニバーシティ Methods and materials of the nanocrystal surface film and deposits of a peptide amphiphile nanofibers onto its
JP5057781B2 (en) * 2003-06-25 2012-10-24 マサチューセッツ インスティテュート オブ テクノロジー Incorporating a modified self-assembling peptides and how to use it
US7713923B2 (en) * 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
JP4741510B2 (en) * 2003-12-05 2011-08-03 ノースウエスタン ユニバーシティ Branched peptide amphiphiles, related epitopes compounds and self-assembling structures
CN102225964A (en) 2003-12-05 2011-10-26 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
EP1781310B1 (en) 2004-08-02 2015-10-14 Ramot at Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
US7786086B2 (en) * 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
KR20070100948A (en) 2005-01-21 2007-10-15 노오쓰웨스턴 유니버시티 Methods and compositions for encapsulation of cells
KR20070108555A (en) * 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 Angiogenic heparin binding peptide amphiphiles
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
WO2008063808A3 (en) * 2006-10-24 2009-04-09 Univ Northwestern Encapsulated peptide amphiphile nanostructures
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
WO2008101104A3 (en) 2007-02-14 2008-11-20 Univ Northwestern Aligned nanofibers and related methods of use
US9066885B2 (en) * 2007-03-16 2015-06-30 University Of Maryland, College Park Advanced functional biocompatible polymeric matrix containing nano-compartments
US8932560B2 (en) * 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
KR101670443B1 (en) * 2007-04-03 2016-11-01 사에스 게터스 에스.페.아. A method for the sorption of gaseous contaminants by means of nanostructured sorbers in the form of a fiber
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8034396B2 (en) * 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
US9399068B2 (en) 2008-06-10 2016-07-26 The Board Of Trustees Of The Leland Stanford Junior University Hetero-assembling, tunable, and injectable hydrogels for cell encapsulation
US9011914B2 (en) 2008-06-10 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Hetero-assembled hydrogels
US8877170B2 (en) * 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
US8663689B2 (en) * 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
US8956603B2 (en) 2009-02-21 2015-02-17 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
CA2753188A1 (en) 2009-02-21 2010-08-26 Tyco Healthcare Group Lp Medical devices having activated surfaces
CA2753173C (en) 2009-02-21 2017-05-30 Sofradim Production Medical devices with an activated coating
WO2010095049A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same by extrusion
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
WO2010095055A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same using uv radiation
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
WO2010095047A3 (en) 2009-02-21 2010-10-14 Sofradim Production Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
WO2010095053A3 (en) 2009-02-21 2010-10-14 Sofradim Production Apparatus and method of reaching polymers by exposure to uv radiation to produce injectable medical devices
EP2398519A2 (en) 2009-02-21 2011-12-28 Sofradim Production Compounds and medical devices activated with solvophobic linkers
US8968818B2 (en) 2009-02-21 2015-03-03 Covidien Lp Medical devices having activated surfaces
US8968733B2 (en) * 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
WO2010111652A3 (en) 2009-03-27 2011-03-24 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
US9334304B2 (en) * 2009-04-02 2016-05-10 The Johns Hopkins University Self-assembling peptides bearing organic electronic functionality and applications employing the same
EP2419116A1 (en) 2009-04-13 2012-02-22 North Western University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US8062555B2 (en) * 2009-04-16 2011-11-22 Rhodia Operations Co-assembly method and co-assembled structures made thereby
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011017382A3 (en) * 2009-08-03 2011-08-04 The Regents Of The University Of California Nanofibers and morphology shifting micelles
CA2780898A1 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
US8835395B2 (en) * 2010-03-10 2014-09-16 Kansas State University Research Foundation Protein peptide hydrogels
EP2550034B1 (en) * 2010-03-25 2015-01-07 Sofradim Production Surgical fasteners and methods for sealing wounds
CA2794335A1 (en) 2010-03-25 2011-09-29 Sofradim Production Medical devices incorporating functional adhesives
WO2011132018A1 (en) 2010-04-19 2011-10-27 Universita' Degli Studi Di Milano Bicocca Novel self-assembling peptides and their use in the formation of hydrogels
EP2588525A4 (en) 2010-06-29 2015-06-10 Covidien Lp Microwave-powered reactor and method for in situ forming implants
US8865857B2 (en) 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
US8664199B2 (en) 2010-08-13 2014-03-04 University Of Maryland, College Park Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
WO2012075457A3 (en) 2010-12-02 2012-11-22 University Of Maryland, College Park Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
KR20130018194A (en) 2011-08-10 2013-02-20 김태국 High density molecular display methods for quantitatively tracking and labelling target molecular interactions using energy transfer and signal alterations
US20140255314A1 (en) * 2011-08-10 2014-09-11 Tae Kook Kim Method for inducing physiological adjustment using high density display of material
US8871903B2 (en) * 2012-10-22 2014-10-28 The Johns Hopkins University Palladium catalyzed reactions executed on solid-phase peptide synthesis supports for the production of self-assembling peptides embedded with complex organic electronic subunits
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
US9616088B2 (en) 2013-03-13 2017-04-11 Gel-E, Inc. Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9200082B2 (en) * 2013-03-14 2015-12-01 The University Of Chicago Methods and compositions involving fibrillizing polypeptides for nanofibers
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
US9517275B2 (en) 2013-09-30 2016-12-13 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
DE102015000363A1 (en) 2015-01-20 2016-07-21 Emc Microcollections Gmbh New modular functionalizable peptide hydrogels
US20170106120A1 (en) * 2015-10-14 2017-04-20 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
US9795718B1 (en) 2016-08-05 2017-10-24 International Business Machines Corporation Biocompatible devices with dissolvable substrates and methods of forming the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007752A1 (en) * 1996-08-23 1998-02-26 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) * 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) * 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0547556B2 (en) 1989-09-11 1993-07-19 Kogyo Gijutsuin
DE4026978A1 (en) * 1990-08-25 1992-02-27 Bayer Ag Coated substrates for electro=optical applications, etc.
EP0585368B1 (en) * 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
DK0759760T3 (en) 1994-07-19 2001-11-26 Medicarb Ab wound healing
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US5622699A (en) 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (en) 1995-10-17 1998-01-02 Coletica amphiphilic complexes, process for their preparation and compositions containing
DE69620028D1 (en) 1995-12-01 2002-04-25 Forskarpatent I Syd Ab Lund Reversible, nichtkovalentgebundene surface coating
US6051272A (en) * 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
KR20000016585A (en) * 1996-06-12 2000-03-25 크레머 브이. Transparent barrier coatings exhibiting reduced thin film interference
US6085206A (en) * 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) * 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US5733866A (en) * 1996-08-22 1998-03-31 International Flavors & Fragrances Inc. Methyl substituted hexahydroindanols and alkyl ethers thereof, organoleptic uses thereof, processes for preparing same and process intermediates therefor
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
WO1998031394A3 (en) * 1997-01-22 1998-09-17 Univ Texas Tissue factor methods and compositions for coagulation and tumor treatment
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
GB2348426B (en) 1997-04-03 2001-06-27 California Inst Of Techn Enzyme-mediated modification of fibrin for tissue engineering
US6181909B1 (en) * 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) * 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
JP4222726B2 (en) * 1997-12-02 2009-02-12 ゼン‐バイオ，インコーポレイテッド Generation and use of osteoblasts
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
EP1073715B1 (en) * 1998-03-30 2013-06-26 Swedish Orphan Biovitrum International AB Methionin containing animal cell culture medium and its use
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
DK1107791T3 (en) 1998-09-04 2007-09-03 Scios Inc Hydrogel for the controlled release delivery of growth factors
CA2277732A1 (en) 1998-09-15 2000-03-15 Isotis B.V. Method for coating medical implants
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
DK1181323T3 (en) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterials formed by nucleophilic addition reaction to conjugated groups uimættede
WO2000045831A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
JP2002537803A (en) 1999-03-02 2002-11-12 ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス Embryonic cell lines or stem-like cell line produced by interspecies nuclear transfer
US6473730B1 (en) * 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
ES2255257T3 (en) 1999-04-22 2006-06-16 Eidgenossische Technische Hochschule (Eth) Controlled release of growth factors from matrices containing heparin.
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
EP1196426A4 (en) 1999-06-30 2003-09-03 Advanced Cell Tech Inc Cytoplasmic transfer to de-differentiate recipient cells
US6444723B1 (en) * 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
WO2001048148A1 (en) 1999-12-28 2001-07-05 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
US20030139327A9 (en) 2000-01-31 2003-07-24 Rosen Craig A. Nucleic acids, proteins, and antibodies
CA2395693A1 (en) 2000-01-31 2001-08-02 Craig A. Rosen Nucleic acids, proteins, and antibodies
DE60100433T2 (en) 2000-02-04 2004-04-15 Chienna B.V. protein coating
US6896054B2 (en) * 2000-02-15 2005-05-24 Mcclung, Iii Guy L. Microorganism enhancement with earth loop heat exchange systems
US6689165B2 (en) * 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
CA2406823A1 (en) 2000-04-28 2001-11-08 Lawrence John Penkler Amphiphilic macrocyclic derivatives and their analogues
CA2408819C (en) * 2000-05-11 2006-11-07 University Of Southern California Machine translation techniques
WO2002020723A3 (en) 2000-09-08 2002-08-29 Univ Texas Compositions and methods for targeting peptides in humans in vivo
US7132475B2 (en) * 2000-10-19 2006-11-07 Ecole Polytechnique Federale De Lausanne Block copolymers for multifunctional self-assembled systems
DE60033576T2 (en) 2000-11-06 2007-10-31 Thrasos, Inc., Waltham Methods for screening knochenmorphogenetishemimetika
WO2002059857A1 (en) * 2001-01-23 2002-08-01 Educational Testing Service Methods for automated essay analysis
DE60230593D1 (en) 2001-02-06 2009-02-12 Massachusetts Inst Technology Peptidgerüstverkapselung of tissue cells and uses thereof
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
WO2003006043A1 (en) * 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
WO2003040336A3 (en) 2001-11-06 2003-12-18 Gen Hospital Corportation Stem and progenitor cell capture for tissue regeneration
WO2003054146A3 (en) 2001-11-14 2004-04-01 Univ Northwestern Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A3 (en) 2002-02-15 2004-04-01 Univ Northwestern Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2005003292A3 (en) 2002-11-12 2005-04-28 Univ Northwestern Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2003084980A3 (en) 2002-04-02 2003-12-11 Univ Northwestern Peptide amphiphile solutions and self assembled peptide nanofiber networks
WO2003090255A3 (en) 2002-04-18 2004-04-01 Univ Northwestern Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (en) 2002-05-30 2005-07-14 Bio Oriented Technol Res Advancement Inst VEGETABLE FULL-LENGTH cDNA AND UTILIZATION THEREOF
WO2004003561A9 (en) 2002-06-27 2004-08-12 Univ Northwestern Peptide rod amphiphiles and self-assembly of same
WO2004024778A3 (en) 2002-07-23 2006-04-13 Elia Beniash Self-assembled hybrid compositions and method of making, using and ordering same
US7534761B1 (en) * 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) * 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
WO2004046167A3 (en) 2002-11-14 2005-07-07 Claussen Randal C Synthesis and self-assembly of abc triblock bola peptide
JP4837553B2 (en) 2003-02-11 2011-12-14 ノースウエスタン ユニバーシティ Methods and materials of the nanocrystal surface film and deposits of a peptide amphiphile nanofibers onto its
WO2005014619A3 (en) 2003-03-28 2005-08-18 Univ Jefferson Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
CN102225964A (en) 2003-12-05 2011-10-26 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
JP4741510B2 (en) 2003-12-05 2011-08-03 ノースウエスタン ユニバーシティ Branched peptide amphiphiles, related epitopes compounds and self-assembling structures
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
WO2005094862A1 (en) * 2004-03-23 2005-10-13 Lifeline Nutraceuticals Corporation Compositions and method for alleviating inflammation and oxidative stress in a mammal
EP1838290A2 (en) 2005-01-21 2007-10-03 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
KR20070100948A (en) 2005-01-21 2007-10-15 노오쓰웨스턴 유니버시티 Methods and compositions for encapsulation of cells
KR20070108555A (en) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 Angiogenic heparin binding peptide amphiphiles
CN1915438A (en) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 New type bracket material for tissue engineering of polypeptide nerve, preparation method and application
US8114835B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
WO2008101104A3 (en) 2007-02-14 2008-11-20 Univ Northwestern Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US20090098652A1 (en) 2007-08-17 2009-04-16 Northwestern University Self assembling peptide systems and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
WO1998007752A1 (en) * 1996-08-23 1998-02-26 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9579351B2 (en) 2003-06-27 2017-02-28 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US8518876B2 (en) 2007-08-03 2013-08-27 PharmalN Corporation Composition for long-acting peptide analogs
US9090664B2 (en) 2007-08-03 2015-07-28 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same

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